KR20220067979A - Composition for improving memory and learning ability including natural plant extract - Google Patents

Abstract

The present invention provides a composition containing a goatsbeard extract having an effect of increasing memory and a cognitive function based on a natural product. According to the present invention, the composition containing a goatsbeard extract can achieve effects of being used for a long time without problems of side effects such as cytotoxicity or the like, increasing memory and a cognitive function, and increasing a learning ability as a natural extract.

Description

Composition for improving memory and learning ability, including extracts from nipae horseback riding {COMPOSITION FOR IMPROVING MEMORY AND LEARNING ABILITY INCLUDING NATURAL PLANT EXTRACT}

The present invention relates to a composition for improving memory and learning ability, comprising an extract of nipae equestrian horse. In more detail, the present invention is to provide a composition based on a natural product that can increase memory and cognitive function improvement activity, and enhance concentration and learning ability. In particular, by providing a new use of the snow-riding, it is to discover a new demand for the snow-riding horse.

As the social environment changes rapidly and diversely, modern people encounter more and more stimuli than in the past, and rapid brain activity is required to accommodate them. Adolescents, especially long-term learning or memory activities, cause mental and physical fatigue of the brain and may affect the healthy development of the brain. After middle age, symptoms such as memory loss or forgetfulness due to central nervous system dysfunction may appear. However, considering the impact on the people around them, a huge social cost can be required.

Neurogenesis (neurogenesis) is a process in which neurons are generated from NPCs (Neuronal precursor cells). It has been believed that the number of brain neurons in adult mammals is limited, and that no new neurons are generated after the developmental stage. However, many studies have revealed that neurogenesis, that is, the generation and differentiation of neurons, occurs continuously during adulthood in the subventricular zone (SVZ) of the lateral ventricle and the granulation zone (SGZ) of the hippocampal denatate gyrus. . Neurogenesis in the adult hippocampus is associated with the regulation of cognitive function. There is growing evidence supporting that new neurons induced by NPCs in the hippocampus play a major role in long-term and short-term spatial memory as well as object recognition memory. In psychology, memory means that changes caused by learning last a long time, so learning and memory are inseparable from each other, and the result of learning is measured through the quantity and quality of memory. Therefore, increase in hippocampal neurogenesis by NPC stimulation is considered a feasible strategy to increase cognitive functions including learning and memory.

As the aging population increases, studies for improving cognitive function have been mainly approached in terms of disease treatment to treat neurodegeneration caused by neurodegenerative diseases. Neurodegeneration is a progressive disease in which neuronal cells of the central nervous system are degenerated according to the accumulation of abnormal protein aggregates and fall into dysfunction or cell death.

However, rapid brain activity is required to accommodate many stimuli in order to live in modern society according to the diversification of social environments even in the case of ordinary people without diseases such as neurodegeneration as well as disease aspects. Learning ability is directly related to intellectual activity ability and ultimately affects quality of life. In addition, modern medicine uses cholinesterase inhibitors as a memory enhancer for children with learning earthquake who have poor academic ability due to congenitally low intellectual ability related to memory, but some effects such as dizziness, tremor, vomiting and liver toxicity are too severe. Nevertheless, its application is limited. Moreover, as the competition for entrance exams intensifies, for students who need long-term learning activities, not only 'remedies' that are effective in improving memory and learning ability, but also drugs used as a treatment for attention deficit hyperactivity disorder to improve short-term concentration are so-called 'studying'. It is also abused as a ‘good drug’. Accordingly, there is a need for a composition for enhancing memory and learning ability that can be used more safely.

Memory refers to the ability to recall events in the past, either consciously or unconsciously. Memory can be divided into unconscious nondeclarative memory, which includes the acquisition of skills and habits, and declarative memory, which can be consciously reproduced, such as facts or events that occurred in the past. However, as complex behaviors such as driving or playing the piano can be performed unconsciously when habituated, narrative memory can be converted into non-narrative memory by repetition.

Descriptive memory consists of working memory, which focuses on present information and stores it temporarily for only a few seconds, short-term memory, which lasts for hours to days, and It is divided into long-term memory (remote memory), etc. Short-term memory includes the period during which memories of ongoing events are converted into long-term memory. During this period, storage as memory is weak and easily forgotten, but once stored in long-term memory, it is not easily forgotten even if there is serious damage to the brain.

Memory can be made up of three stages. First, the input stage of memorizing new information or knowledge and inputting it into the brain, the second storing stage of storing the information or knowledge inputted into the brain in the brain, and the third storing the stored information. This is the recall phase, in which information or knowledge is reconsidered. If any one of the above three steps is abnormal, a phenomenon in which information or knowledge cannot be accurately remembered, that is, memory deterioration or decline may occur.

The decrease or decline of the memory is caused by various causes, such as a decrease in the amount of acetylcholine due to the action of acetylcholinesterase in neurons of brain tissue, and neurotoxicity caused by β-amyloid (βA). Necrosis is known to be the cause.

For this reason, both surgical and pharmacological methods are currently used for the deterioration or decline of memory ability, but the surgical method is not easy, so the pharmacological method is recommended. As the above pharmacological method, inhibitors of the activity of acetylcholinesterase, an enzyme that decomposes acetylcholine (tacrine, aricept, donepezil, rivastigrin or galantamine, etc.), are commercially available, but they do not reduce or decrease memory ability. Rather than treating it, it only shows temporary symptom improvement by regulating neurotransmitters. Moreover, side effects such as hepatotoxicity, gastrointestinal disorders, cardiac bradycardia, weight loss and insomnia, and toxicity or dependence due to long-term use are pointed out as problems, and the development of new products is required to compensate for these problems.

KR 10-2010-0135083 A KR 10-2004-0062273 A

It is an object of the present invention to provide a composition comprising an extract of nipae equestrian horse having an effect of improving memory and cognitive function based on a natural product.

The composition comprising the extract of nipae equestrian according to the present invention is a natural extract, and there is no problem of side effects such as cytotoxicity, so that it can be used for a long period of time to achieve the effect of improving memory and cognitive function and enhancing learning ability will be.

It is an object of the present invention to provide a food or health functional food of various formulations capable of improving memory and cognitive function, including the extract of nipae equestrian horse.

An object of the present invention is to suggest a new use for the snow horse riding, and through this, it is commercialized as a variety of functional products, so that a new demand for the snow horse riding can be discovered.

In order to achieve the above object, the composition for improving memory and cognitive function according to an embodiment of the present invention is to include an extract of nipae equestrian horse.

The extract may be one selected from the group consisting of water, alcohols having 1 to 10 carbon atoms, and mixtures thereof with a solvent.

The composition for improving memory and cognitive function may further include a lotus flower extract or an oleifera extract.

The composition for improving memory and cognitive function may further include a noni extract.

Food for improving memory and learning ability according to another embodiment of the present invention may include the composition.

The food is Schisandra extract, strawberry extract, acai berry extract, aronia extract, blueberry extract, cranberry extract, grapefruit extract, orange extract, lemon extract, chocomint extract, basil extract, peppermint extract, sage extract, lavender extract, parsley It may be to further include any one selected from the group consisting of extracts, gompi extract, beetroot extract, coltsfoot extract, soothing extract, and mixtures thereof.

A health functional food for improving memory and learning ability according to another embodiment of the present invention may include the composition.

The health functional food is Schisandra extract, strawberry extract, acai berry extract, aronia extract, blueberry extract, cranberry extract, grapefruit extract, orange extract, lemon extract, chocomint extract, basil extract, peppermint extract, sage extract, lavender extract , parsley extract, gompi extract, beetroot extract, coltsfoot extract, soothing extract, and any one selected from the group consisting of a mixture thereof may be further included.

Hereinafter, the present invention will be described in more detail.

The composition for improving memory and cognitive function according to an embodiment of the present invention is to include an extract of nipae equestrian horse.

The above snowgae horseback riding is a perennial herb that grows in alpine areas throughout the country. The growing environment is deciduous and grows wild in semi-shade or shaded areas. It is 30~100cm tall, and the leaves are 3~10cm long and 1~6cm wide and have long glossy petioles. It is a pinnate compound leaf that splits like a feather about 2 or 3 times, and has a sharp tip and a sawtooth in the shape of digging into the edge. The flowers are white, 10~30cm long, spread out in the shape of a fan, bloom from the bottom and go up. The fruits ripen in July-August, are brown, oval, and about 0.3 cm long, and have a brilliance when ripe. It is used as an ornamental, and the young shoots are used for food. If there is no particular designation or limitation in the present invention, it can be understood that the nungae riding horse refers to the young shoots of the nungae riding horse. However, the riding horse according to the present invention is not limited thereto.

As used herein, the term "extract" has the meaning commonly used as a crude extract in the art as described above, but in a broad sense also includes a fraction obtained by additionally fractionating the extract. That is, the extract of nipae equestrian horse includes not only those obtained using the above-described extraction solvent, but also those obtained by additionally applying a purification process here. For example, a fraction obtained by passing the extract through an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (prepared for separation according to size, charge, hydrophobicity or affinity), etc. The fraction obtained through the purification method is also included in the extract of the present invention.

The snow gae equestrian extract can achieve the effect of improving memory and cognitive function. Memory and cognitive function are improved by the activity of the active ingredients contained in nungae horseback riding, so it is possible to prevent or improve diseases caused by memory loss such as forgetfulness, and it can have the effect of enhancing the learning ability for examinees, etc.

The composition for improving memory and cognitive function may further include a lotus flower extract or an oleifera extract. Alternatively, the composition for improving memory and cognitive function may include a noni extract. Also preferably, the composition for improving memory and cognitive function may further include a chazugi extract. In the case of the above range, memory and cognitive function improvement activity may be increased due to a synergistic effect by interaction. In addition, it may further include raw paper, guyeopcho, seokchangpo, etc. as needed.

On the other hand, the composition for improving memory and cognitive function according to the present invention is a lotus extract; elm extract; noni extract; Chazugi extract may be included. In the case of the above combination, the activity of improving memory and cognitive function may be enhanced according to the synergistic effect by the interaction of each extract. In particular, a unique synergistic effect that does not appear in the case of mixing of other plant extracts can be confirmed.

More preferably, the composition for improving memory and cognitive function includes: 1 to 5 parts by weight of lotus extract, 10 to 30 parts by weight of extract of oleracea; 1 to 5 parts by weight of the noni extract and 5 to 15 parts by weight of the chazugi extract may be further included.

In the case of the above range, the activity of improving memory and cognitive function may be very excellent. In particular, it can exhibit excellent memory and cognitive function improvement activity that cannot be found in a mixture of other extracts or other mixing ranges.

In the composition for improving memory and cognitive function, the extract may be one selected from the group consisting of water, alcohols having 1 to 10 carbon atoms, and mixtures thereof with a solvent.

Preferably, the solvent may be water. When water is used as a solvent to prepare the extract of nevi horseradish, it may be advantageous to obtain an effective substance.

Food for improving memory and learning ability according to another embodiment of the present invention may include the composition.

As a specific example, by using the food composition, it is possible to prepare a processed food capable of enhancing the antibacterial, anti-inflammatory, antiviral and immune function improvement effects. Such processed foods include, for example, sweets, tea, beverages, alcoholic beverages, fermented foods, canned foods, milk products, processed meat foods, noodles, and the like. Confectionery includes biscuits, pies, cakes, breads, candies, jellies, gums, cereals, and the like. The beverage includes drinking water, carbonated beverage, functional ionized beverage, functional ionized beverage, juice (eg, apple, pear, grape, aloe, tangerine, peach, carrot, tomato juice, etc.), sikhye, and the like. Alcoholic beverages include sake, whiskey, shochu, beer, Western liquor, fruit wine, and the like. Fermented foods include soy sauce, soybean paste, red pepper paste, and the like. Canned foods include canned seafood (eg, canned tuna, mackerel, saury, conch, etc.), canned livestock products (canned beef, pork, chicken, turkey, etc.), and canned agricultural products (canned corn, peaches, file apples, etc.). Milk products include cheese, butter, yogurt, and the like. Processed meat products include pork cutlet, beef cutlet, chicken cutlet, and sausage. Includes sweet and sour pork, nuggets, and breadcrumbs. Noodles such as sealed packaged raw noodles are included. In addition to this, the composition may be used in retort foods, soups, and the like.

The food is Schisandra extract, strawberry extract, acai berry extract, aronia extract, blueberry extract, cranberry extract, grapefruit extract, orange extract, lemon extract, chocomint extract, basil extract, peppermint extract, sage extract, lavender extract, parsley It may be to further include any one selected from the group consisting of extracts, gompi extract, beetroot extract, coltsfoot extract, soothing extract, noni extract, and mixtures thereof.

The food shall include general food, processed food, health functional food, and functional food, and for example, the formulation for the food may be applied to beverages, tea, tablets, processed meat food, snacks, instant food, etc. .

A health functional food for improving memory and learning ability according to another embodiment of the present invention may include the composition.

The health functional food is Schisandra extract, strawberry extract, acai berry extract, aronia extract, blueberry extract, cranberry extract, grapefruit extract, orange extract, lemon extract, chocomint extract, basil extract, peppermint extract, sage extract, lavender extract , parsley extract, gompi extract, beetroot extract, coltsfoot extract, soothing extract, and any one selected from the group consisting of a mixture thereof may be further included.

Preferably, the food or health functional food is 0.1 to 1 part by weight of Omija based on 100 parts by weight of the extract of Nungae equestrian horse; 0.1 to 1 part by weight of cranberry extract; It may further include 0.1 to 2 parts by weight of peppermint extract, 1-3 parts by weight of parsley extract, and 0.1 to 1 parts by weight of soothing extract. According to the above range, it can be provided as a food composition with a palatable texture with a fairly deep and refreshing flavor while neutralizing the low palatability and taste of the extract of nipae extract. In particular, when according to the above range, it is included in less than 10% by weight compared to the nipae equestrian extract, and improves the taste and flavor of the nipae equestrian extract as described above without compromising the functionality of the nipae equestrian extract, making it a highly palatable food composition can provide In addition, the above-mentioned gompi extract; Even in the case of adding a persimmon leaf extract and chazugi extract, the taste and flavor are excellent, so the palatability is high, and it has the advantage that the activity of the active ingredient desired in the present invention can be maintained as much as possible.

The health functional food is not particularly limited as long as it can be ingested to improve cognitive function or memory ability, or to prevent related diseases such as memory and cognitive function related diseases such as forgetfulness.

When the health functional food composition of the present invention is used as a food additive, the health functional food composition may be added as it is or used together with other foods or food ingredients, and may be appropriately used according to a conventional method. The active ingredient may be used appropriately depending on the purpose of its use (prevention or improvement). In general, in the production of food or beverage, the health functional food composition of the present invention is added in an amount of 15 parts by weight or less, preferably 10 parts by weight or less, based on the raw material. However, in the case of long-term intake for health purposes, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount above the above range.

There is no particular limitation on the type of the health functional food. The health functional food composition of the present invention may be prepared as a food, particularly a functional food. The functional food of the present invention is

It includes ingredients commonly added during food production, and includes, for example, proteins, carbohydrates, fats, nutrients and seasonings. For example, when manufactured as a drink, natural carbohydrates or flavoring agents may be included as additional ingredients in addition to the active ingredient. The natural carbohydrates include monosaccharides (eg, glucose, fructose, etc.), disaccharides (eg, maltose, sucrose, etc.), oligosaccharides, polysaccharides (eg, dextrin, cyclodextrin, etc.) or sugar alcohols (eg, , xylitol, sorbitol, erythritol, etc.) is preferable. As the flavoring agent, natural flavoring agents (eg, taumatine, stevia extract, etc.) and synthetic flavoring agents (eg, saccharin, aspartame, etc.) may be used.

In addition to the health functional food composition, various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonic acid It may further contain a carbonation agent and the like used in beverages.

The present invention provides a composition comprising an extract of naengae horseback riding having an effect of improving memory and cognitive function based on a natural product.

The composition comprising the extract of nipae equestrian according to the present invention is a natural extract, and there is no problem of side effects such as cytotoxicity, so that it can be used for a long period of time, and can achieve the effect of improving memory and cognitive function and enhancing learning ability.

The present invention provides foods or health functional foods of various formulations that can improve memory and cognitive function, including the extract of nipae equestrian horse.

The present invention proposes a new use for the snow horse riding, and through this, it is commercialized into various functional products, so that a new demand for the snow horse riding can be discovered.

Hereinafter, embodiments of the present invention will be described in detail so that those of ordinary skill in the art can easily carry out the present invention. However, the present invention may be embodied in several different forms and is not limited to the embodiments described herein.

[Preparation Example: Preparation of Snow Gaeseosaurus Extract]

1. Manufacture of snow horse equestrian extract

After washing and drying young shoots, pulverized, hot water extraction, and concentrated filtration were performed to prepare an extract of nevi horseradish (KJB). The following experiment was carried out while diluting the nurigae equestrian extract to a certain concentration.

2. Preparation of Mixed Extracts

Through hot water extraction according to the same method as above and KJB, lotus flower extract (AD1); elm extract (AD2); Noni extract (AD3), Chazugi extract (AD4), Schisandra extract (E1), cranberry extract (E2), peppermint extract (E3), parsley extract (E4) and soothing extract (E5) were prepared, and each extract was prepared as follows. A mixed composition was prepared according to the composition shown in [Table 1].

M1 M2 M3 M4 M5 T1 T2 T3 T4 T5 KJB 100 100 100 100 100 100 100 100 100 T6 AD1 0.1 One 3 5 10 - - - - 100 AD2 One 10 15 30 40 - - - - 3 AD3 0.1 One 3 5 10 - - - - 15 AD4 One 5 10 15 20 - - - - 3 E1 - - - - - 0.01 0.1 One 3 10 E2 - - - - - 0.1 One 3 5 One E3 - - - - - 0.01 0.1 2 5 3 E4 - - - - - One One 3 5 2 E5 - - - - - 0.1 0.1 2 5 3

(Unit: parts by weight)

[Experimental Example 1: Memory and cognitive function improvement effect experiment]

1. DPPH radical analysis

For the analysis of reactive oxygen species such as DPPH and superoxide anion related to oxidative stress in vivo, the radical scavenging ability of KJB and M1 to M5 was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. did After reacting by adding a DPPH solution to KJB and M1 to M5, absorbance was measured. The DPPH radical content is shown in [Table 2] by converting the absorbance ratio of the sample addition group and the control group to a % value.

KJB M1 M2 M3 M4 M5 DPPH radical (%) 59 65 47 41 46 58

2. Reducing Power Analysis

Superoxide anion radical scavenging activity was performed according to the Fridovich method. To 1 ml of the sample, 200 mM phosphate buffer at pH 6.6 and 1 ml of potassium ferricyanide were sequentially added and reacted. Here, 10% TCA (trichloroacetic acid) solution was mixed with distilled water and ferric chloride in the supernatant, and absorbance was measured. KJB and M1 to M5 are shown in [Table 3] below by converting the absorbance ratio into % value based on the value of the control group.

KJB M1 M2 M3 M4 M5 Superoxide anion (%) 245 258 345 364 352 276

3. Analysis of DNA damage by hydroxyl radical

Genomic DNA was extracted from PC12 cells according to a slightly modified standard procedure. To the DNA solution, KJB and M1 to M5, 200 μM FeSO4, 1 mM H2O2, and 50 μg/ml genomic DNA were added. After completion of the reaction, electrophoresis was performed. After dyeing, it was observed using a LAS3000 image analyzer with UV light, and the results were expressed in % based on the untreated group and shown in [Table 4] below, and the lower the % value, the better.

KJB M1 M2 M3 M4 M5 DNA oxidation(%) 71 69 53 51 53 64

4. Measurement of Angiotensin I Converting Enzyme (ACE) Activity

ACE activity was pre-reacted by adding sodium borate buffer (pH 8.3) and ACE coenzyme to KJB and M1 to M5, respectively, and then reacted by adding a substrate prepared by adding HHL (hippuryl-histidyl-leucine). Meanwhile, the ACE coenzyme solution was prepared by extracting rabbit lung acetone powder in sodium borate buffer (pH 8.3) and then centrifuging. The supernatant collected after the reaction was mixed with dried and distilled water, and absorbance was measured. Distilled water was used as a negative control group, and the absorbance ratio before and after addition of the sample was converted into % values based on the untreated group as a standard (100%), and is shown in [Table 5] below.

KJB M1 M2 M3 M4 M5 ACE inhibition (%) 202 211 235 242 240 216

5. AChE (Acetylcholine esterase) activity measurement

50 μl of AchE (25 mU/ml) isolated from PC12 cells was used as a reaction enzyme, and acetylcholine iodide dissolved in 0.1 M sodium phosphate buffer (pH 7.8) was used as a substrate, and the chromogenic reagent was 5,5'-dithiobis-2 -nitrobenzoic acid and sodium hydrogen carbonate were dissolved in 10 ml of 0.1 M sodium phosphate buffer (pH 7.0). After the reaction, the absorbance value was measured at 412 nm with a spectrophotometer. The activity of AChE is shown in [Table 6] below by converting the absorbance ratio before and after the addition of KJB and M1 to M5 into % values based on the untreated group (100%).

KJB M1 M2 M3 M4 M5 AChE activity (%) 54 57 48 43 45 53

6. Test for NF-κB transcriptional activity in C12 cells

While culturing PC12 cells, the transcriptional activity of NF-κB was evaluated using the NF-κB promoter-luciferase construct, and the effect on NF-κB transcriptional activity in C12 cells for KJB and M1 to M5 was compared. The results of KJB were fixed at 10, and the results of M1 to M5 were evaluated as relative indices, and are shown in [Table 7]. The higher the index, the better the transcriptional activity of NF-κB.

KJB M1 M2 M3 M4 M5 Relative luciferase activity 10 10 15 16 16 12

In the end, according to the present invention, removal of reactive oxygen species, antioxidant against DNA damage, ACE (Angiotensin Converting Enzyme) enzyme inhibitory activity, AChE (acetylcholine esterase) inhibitory activity, NO (nitric oxide) production inhibitory activity, NF-κB transcription It can be seen that the activity increasing effect appears. In addition, it can be seen that a certain synergistic effect appears in the case of the mixed composition of M2 to M4.

Therefore, it can be applied to a variety of products that can produce effects for improving memory and brain cognitive function based on the mixed composition of the nipae equestrian extract or the nipae equestrian extract.

7, general land maze experiment

After learning the passage of the radial maze made of a constant size for 2 weeks, the mice were given M1 to M5 3 times a day for 4 days, and then the time required to pass through the prepared maze was measured 3 times. . As a control group, a group ingesting purified water was used, and it was evaluated as an index of 1 to 10 compared to the time result of the control group. On the other hand, the higher the number of the index, the better the effect.

The results are shown in [Table 8] below.

Con KJB M1 M2 M3 M4 M5 Y maze test One 3 3 5 6 5 3

(Unit: Index)

Referring to [Table 8], in the case of KJB and the mixed formulations M1 to M5, it can be seen that the memory enhancing effect appears. In particular, in the case of M2 and M4, it can be seen that the memory improving activity is greatly increased due to the synergistic effect according to the mutual combination of each composition. Through this, it can be confirmed that, according to the content range of M2 and M4, it is possible to provide a composition capable of enhancing memory-improving activity while taking it for a long time without problems of side effects such as cytotoxicity with a small content.

[Experimental Example 2: Evaluation of palatability]

A tea beverage was prepared according to the composition of KJB and T1 to T5, and after tasting it, 10 testers were asked to evaluate the flavor and taste to evaluate the preference of 1 to 10. The results are summarized and averaged and shown in [Table 9] below. In the following indices, the higher the number, the better the preference (rounding is applied to the average value for each index).

KJB T1 T2 T3 T4 T5 palatability 3 2 6 6 3 6

(Unit: Index)

Referring to the palatability evaluation result, it was confirmed that most of the tasters showed a low evaluation score in the overall palatability evaluation because of the bitter and strong scent of the nungae equestrian extract unlike the nungae equestrian horse itself. However, in the case of the mixed composition of T2 and T3, it was confirmed that the overall taste and flavor were excellent while the overall sweet and sweet scent and the unique flavor of Nonigaeseungma were neutralized, so that it felt soft.

In particular, referring to T5, according to the mixed composition, since the mixture of E1 to E5 is contained in an amount of less than 10% by weight based on the extract of nipae equestrian horse, the palatability can be excellent while maintaining the activity according to the active ingredient of nipae equestrian horse as much as possible. In addition, it can be seen that, in the case of the above composition, the effect of improving palatability can be achieved even in the composition for M3.

Although preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention as defined in the following claims are also provided. is within the scope of the

Claims (5)

Containing snow horse riding extract
A composition for improving memory and cognitive function. The method of claim 1,
The extract is
Any one selected from the group consisting of water, alcohols having 1 to 10 carbon atoms and mixtures thereof is extracted with a solvent
A composition for improving memory and cognitive function. The method of claim 1,
Which further comprises a lotus flower extract or elm oleifera extract
A composition for improving memory and cognitive function. 4. The method of claim 3,
Which further comprises a noni extract
A composition for preventing and improving ischemic reperfusion injury. 5. A composition comprising the composition according to any one of claims 1 to 4,
Food for improving memory and learning ability.