KR20220057525A - 알파-하이드록시 산의 에스테르화에 의한 알파-하이드록시 에스테르의 제조 공정 - Google Patents

알파-하이드록시 산의 에스테르화에 의한 알파-하이드록시 에스테르의 제조 공정 Download PDF

Info

Publication number
KR20220057525A
KR20220057525A KR1020227004895A KR20227004895A KR20220057525A KR 20220057525 A KR20220057525 A KR 20220057525A KR 1020227004895 A KR1020227004895 A KR 1020227004895A KR 20227004895 A KR20227004895 A KR 20227004895A KR 20220057525 A KR20220057525 A KR 20220057525A
Authority
KR
South Korea
Prior art keywords
formula
compound
reaction
hours
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020227004895A
Other languages
English (en)
Korean (ko)
Inventor
셩슈 황
팡이 리
리 쑤
필립 누옌스
예 라오
자투폰 살라클랑
주오 탕
Original Assignee
케민 인더스트리즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 케민 인더스트리즈, 인코포레이티드 filed Critical 케민 인더스트리즈, 인코포레이티드
Publication of KR20220057525A publication Critical patent/KR20220057525A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A23K50/15—Feeding-stuffs specially adapted for particular animals for ruminants containing substances which are metabolically converted to proteins, e.g. ammonium salts or urea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C07C319/30—Separation; Purification from the by-products of refining mineral oils
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020227004895A 2019-09-06 2020-09-03 알파-하이드록시 산의 에스테르화에 의한 알파-하이드록시 에스테르의 제조 공정 Ceased KR20220057525A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019104692 2019-09-06
CNPCT/CN2019/104692 2019-09-06
PCT/US2020/049222 WO2021046234A1 (en) 2019-09-06 2020-09-03 Processes for the preparation of alpha-hydroxy esters by esterification of alpha-hydroxy acids

Publications (1)

Publication Number Publication Date
KR20220057525A true KR20220057525A (ko) 2022-05-09

Family

ID=74852116

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227004895A Ceased KR20220057525A (ko) 2019-09-06 2020-09-03 알파-하이드록시 산의 에스테르화에 의한 알파-하이드록시 에스테르의 제조 공정

Country Status (11)

Country Link
US (2) US20220332681A1 (cg-RX-API-DMAC7.html)
EP (1) EP4025561A4 (cg-RX-API-DMAC7.html)
JP (2) JP7765382B2 (cg-RX-API-DMAC7.html)
KR (1) KR20220057525A (cg-RX-API-DMAC7.html)
CN (2) CN121318803A (cg-RX-API-DMAC7.html)
AU (1) AU2020343325A1 (cg-RX-API-DMAC7.html)
CA (1) CA3150773A1 (cg-RX-API-DMAC7.html)
CL (3) CL2022000516A1 (cg-RX-API-DMAC7.html)
CO (1) CO2022003063A2 (cg-RX-API-DMAC7.html)
MX (1) MX2022002512A (cg-RX-API-DMAC7.html)
WO (1) WO2021046234A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7846005B2 (ja) * 2019-11-22 2026-04-14 ケミン、インダストリーズ、インコーポレーテッド グリニャールカップリング反応及びチオール化反応によるα－ヒドロキシエステルの製造方法
KR102829625B1 (ko) * 2022-03-29 2025-07-04 한국바이오켐제약 주식회사 페노피브릭산의 정제방법 및 이에 의해 제조된 페노피브레이트

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874877A (en) * 1988-04-19 1989-10-17 Pfizer Inc. Process for optically active 3-(methane-sulfonyloxy)thiolane and analogs
JPH06316557A (ja) * 1993-03-06 1994-11-15 Fuji Kagaku Kogyo Kk アルキルチオ脂肪酸誘導体、製造法及びその肝臓疾患、腎臓疾患、膵臓疾患及び脳疾患用剤
FR2785773B1 (fr) * 1998-11-13 2001-04-20 Rhone Poulenc Nutrition Animal Utilisation d'esters de methionine en nutrition animale
FR2791673B1 (fr) * 1999-04-02 2001-06-08 Rhone Poulenc Animal Nutrition Procede de preparation des esters de l'acide hydroxymethylthiobutyrique
WO2001058864A1 (en) * 2000-02-07 2001-08-16 Rhone-Poulenc Animal Nutrition Process for the preparation of 2-hydroxy-4-methylthio butyric acid esters
WO2003070684A1 (en) * 2002-02-19 2003-08-28 Amato Pharmaceutical Products, Ltd. Process for producing chain oligolactic acid ester
US20080319043A1 (en) * 2005-05-03 2008-12-25 Mohammad Salman 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists
CN101489998B (zh) * 2006-07-21 2013-01-02 住友化学株式会社 生产2-羟基-4-(甲硫基)丁酸或丁酸酯化合物及其中间体的方法
CN102093271A (zh) * 2011-01-25 2011-06-15 张维军 2-羟基-4-甲硫基丁酸烷基酯的制备方法
RU2019131408A (ru) * 2014-11-28 2019-10-29 Хальдор Топсёэ А/С Способ получения сложных эфиров молочной кислоты из сахаров
MY198309A (en) * 2016-06-24 2023-08-22 Novus Int Inc Hydroxy methionine analog formulations suibtable for specialty chemical applications
CN111825584B (zh) * 2020-07-30 2022-04-12 北京福元医药股份有限公司沧州分公司 一种消旋羟蛋氨酸钙的制备方法

Also Published As

Publication number Publication date
JP2022546018A (ja) 2022-11-02
MX2022002512A (es) 2022-08-22
CN121318803A (zh) 2026-01-13
WO2021046234A1 (en) 2021-03-11
EP4025561A1 (en) 2022-07-13
CL2022000516A1 (es) 2022-10-07
JP2025041771A (ja) 2025-03-26
CL2024002285A1 (es) 2024-12-27
BR112022003547A2 (pt) 2022-05-17
AU2020343325A1 (en) 2022-03-03
JP7765382B2 (ja) 2025-11-06
US20220332681A1 (en) 2022-10-20
CL2024002284A1 (es) 2024-12-27
CN114341107A (zh) 2022-04-12
CO2022003063A2 (es) 2022-04-19
CA3150773A1 (en) 2021-03-11
US20260001837A1 (en) 2026-01-01
EP4025561A4 (en) 2024-01-31

Similar Documents

Publication Publication Date Title
US20260001837A1 (en) Processes for the Preparation of Alpha-Hydroxy Esters by Esterification of Alpha-Hydroxy Acids
AU714151B2 (en) Processes for the preparation of 3-(methylthio)propanal and 2-hydroxy-4-(methylthio)butanenitrile
JP4172836B2 (ja) ２−ヒドロキシ−４−メチルチオ酪酸の製造法、該方法により製造された２−ヒドロキシ−４−メチルチオ酪酸、および該化合物の使用
US5705675A (en) Processes for the preparation of 3-(methylthio)propanal and 2-hydroxy-4-(methylthio)butanenitrile
MXPA97009461A (en) Process for the preparation of 3- (methylene) propanal and 2-hydroxy-4- (methylthy) butanonitr
US20250346551A1 (en) Preparation and purification of cis-2-alkenoic acids
JP2022546018A5 (cg-RX-API-DMAC7.html)
BR112022003547B1 (pt) Método de preparar ésteres alfa-hidróxi por esterificação de ácidos alfa-hidróxi
JP7846005B2 (ja) グリニャールカップリング反応及びチオール化反応によるα－ヒドロキシエステルの製造方法
BR122025013903A2 (pt) Processos para a preparação de ésteres alfa-hidróxi por esterificação de ácidos alfa-hidróxi
BR122025013902A2 (pt) Processos para a preparação de ésteres alfa-hidróxi por esterificação de ácidos alfa-hidróxi
US6093857A (en) Preparation of cyclopentanols
WO2025221724A1 (en) Processes for the preparation of alpha-hydroxy esters by an acid catalyzed reaction of alpha-hydroxy amides with alcohols
CN114369046A (zh) 2-羟基-4-(甲硫基)丁酸异丙酯的合成方法及其产品与应用
FR2580644A1 (fr) Derives de l'acide ascorbique
KR870001042B1 (ko) 분지상 알카노인산의 제조방법
KR100673593B1 (ko) Ｌ-카르니틴의 제조방법
CN1303845A (zh) 一种合成2,2－二甲基－3－(1－丙烯基)环丙烷羧酸酯的方法
FR2589466A1 (fr) Procede de preparation de composes porteurs de motifs alkoxyalkylidenes
CS274592B1 (en) Method of 2-/(4-aminobenzoamido) ethyl/-diethylammonium chloride preparation

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13 Pre-grant limitation requested

Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

B15 Application refused following examination

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B15-EXM-PE0601 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

E13 Pre-grant limitation requested

Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000