KR20220017537A - a hair dye and medicinal composition made from coffee and melatonin as an active ingredient - Google Patents

a hair dye and medicinal composition made from coffee and melatonin as an active ingredient Download PDF

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KR20220017537A
KR20220017537A KR1020200097090A KR20200097090A KR20220017537A KR 20220017537 A KR20220017537 A KR 20220017537A KR 1020200097090 A KR1020200097090 A KR 1020200097090A KR 20200097090 A KR20200097090 A KR 20200097090A KR 20220017537 A KR20220017537 A KR 20220017537A
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vitamin
melatonin
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김재천
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김재천
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
    • A61Q5/065—Preparations for temporary colouring the hair, e.g. direct dyes
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair
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Abstract

The present invention relates to a hair dye and a pharmaceutical composition which blocks dihydrotestosterone and forms collagen by irradiating 1LX -1000LX light and a performing fermentation reaction of at least one selected from coffee, melatonin, dietary sulfur, resveratrol, fisetin, quercetin, vitamin B6, and vitamin C. When the generated pharmaceutically active ingredient is sprayed onto the scalp, it restores hair follicles, removes inflammation, and promotes hair growth. At the same time, the present invention dyes the hair brown and is naturally harmless, so it can be consumed by drinking the active pharmaceutical ingredient.

Description

커피와 멜라토닌을 유효성분으로 생성된 염모제 및 약학적 조성물{a hair dye and medicinal composition made from coffee and melatonin as an active ingredient} A hair dye and medicinal composition made from coffee and melatonin as an active ingredient

본 발명은 커피와 항노화 물질을 유효성분 생성된 염모제 및 약학적 조성물에 관한 것이다 보다 상세하게는 커피 생두 및 로스팅한 커피의 추출물에 멜라토닌(Melatonin) 및 식이유황(MSM: Methyl Sulfonyl Methane) 피세틴(Fisetin)케르세틴(Quercetin) 레스베라트롤(Resveratron) 비타민B6 비타민C 중에서 선택한 1종 이상을 포함하여 생성된 염모제 및 약학적 조성물에 관한 것이다 The present invention relates to a hair dye and a pharmaceutical composition produced by using coffee and an anti-aging substance as active ingredients. (Fisetin) Quercetin (Quercetin) Resveratrol (Resveratron) It relates to a hair dye and a pharmaceutical composition produced including at least one selected from vitamin B6 and vitamin C

본 발명으로 수득한 조성물은 두피에 도포하면 손상된 모낭 복원과 콜라겐을 형성하고 다이하드로테스토스테론(dihydrotestosterone) DHT를 차단하여 탈모를 방지하고 발모를 촉진하며 동시에 모발을 갈색으로 염색 할 수 있다When the composition obtained by the present invention is applied to the scalp, it restores damaged hair follicles and forms collagen, prevents hair loss by blocking dihydrotestosterone DHT, promotes hair growth, and at the same time dyes hair brown.

신체기관의 기능이 저하되는 인체의 노화는 시간과 비례하여 세포가 손상되며 20세부터 피부의 노화도 진행된다 피부는 표피, 진피, 피하지방으로 이루어지며 표피는 바깥층이며 진피는 표피 아래에 있다 피부의 가장 두꺼운 층으로 피부의 탄력을 결정하는 단백질인 콜라겐이 진피층의 약 70%를 형성하고 있다 인체의 노화가 진행되면서 콜라겐과 피하지방이 감소하면 주름이 생기고 두피는 노화한다 환경적 요인으로는 자외선을 과도하게 조사받으면 DNA가 손상되고 두피의 노화가 촉진된다 30세부터 멜라닌 감소로 흰모발이 10%~ 20% 증가하며 모낭이 손상되고 탈모도 진행된다 흰모발을 염색하기 위한 방법으로 사용하는 종래의 산화형 염모제는 p-페닐렌다이아민, 과산화 수소 등과 같은 유해한 화학물질이 사용되므로 반복 사용하면 예외없이 두피와 모발을 파괴하므로 두피염증, 모낭손상,탈모 및 모발을 손상하는 단점을 피할 수 없다 이와 같은 문제점을 해결 하기 제안으로 발명으로 한국공개허10-2011-0060379호 에서는 녹차 카테킨에 pH 조절제를 함유하는 제 1제와 매염제를 함유하는 제 2제로 구성되는 염모제 조성물에 대하여 개시하고 있으며 한국등록특허 10-1809561호 에서는 커피추출물, 암라파우더 및 마추출물을 포함하는 모발 염색제 조성물 및 이의 제조방법에서 커피추출물이 모발 염색제에 의한 두피 자극을 완화시키고 냄새를 감소시키는 방법을 개시하고 있다 공개특허 10-2018-0092528호에서는 커피찌꺼기를 이용한　모발 염색용 조성물 및 이의 제조 방법에 관한 것으로서, 보다 구체적으로는 커피를 추출하고 남은　커피찌꺼기의 추출물을 모발을 염색하는 샴푸 또는 컨디셔너 에 첨가하는 조성물에 대하여 개시하고 있다 공개특허 10-2019-0135106호 에서는 천연 헤나에 강황을 혼합하고 염도를 갖는 해수로 반죽하여 천연모발염색제를 제조하는 방법을 개시하고 있다 등록특허 10-2014680호 에서는 모발을 염색하는 동안 두피 자극을 완화시키고 모발의 손상을 최소화하는 커피 추출물이나 녹차 추출물을 포함하는 염모제 조성물을 시술하는 방법에 관하여 개시하고 있다 Aging of the human body, in which the function of body organs deteriorates, damages cells in proportion to time, and aging of the skin also proceeds from the age of 20. The skin consists of the epidermis, dermis, and subcutaneous fat. As the thickest layer, collagen, the protein that determines the elasticity of the skin, forms about 70% of the dermis layer. As the human body ages, collagen and subcutaneous fat decrease, causing wrinkles and aging the scalp. Excessive irradiation damages DNA and accelerates aging of the scalp Oxidation-type hair dye uses harmful chemicals such as p-phenylenediamine and hydrogen peroxide, so repeated use destroys the scalp and hair without exception, so scalp inflammation, hair follicle damage, hair loss and hair damage are inevitable As a proposal to solve the same problem, Korean Patent Application Laid-Open No. 10-2011-0060379 discloses a hair dye composition comprising a first agent containing a pH adjusting agent in green tea catechin and a second agent containing a mordant. No. 10-1809561 discloses a hair dye composition comprising coffee extract, amla powder and hemp extract, and a method in which the coffee extract relieves scalp irritation caused by hair dye and reduces odor in a method for preparing the same -0092528 discloses a composition for hair dyeing using coffee grounds and a method for manufacturing the same, and more specifically, a composition in which an extract of coffee grounds remaining after extracting coffee is added to a shampoo or conditioner for dyeing hair. Patent Publication No. 10-2019-0135106 discloses a method for producing a natural hair dye by mixing natural henna with turmeric and kneading it with salty seawater. Coffee that minimizes hair damage Disclosed is a method of treating a hair dye composition containing an extract or green tea extract

1. 특허 10-2011-0060379호1. Patent No. 10-2011-0060379 1. 특허 10-1809561호1. Patent No. 10-1809561 1. 특허 10-2018-0092528호1. Patent 10-2018-0092528 1. 특허 10-2019-0135106호1. Patent 10-2019-0135106 1. 특허 10-2014680호1. Patent 10-2014680

본 발명의 목적은 커피와 홍차 추출물에 멜라토닌 및 식이유황(MSM) 세라틴,케르세틴,레스베라트롤 비타민B6 비타민C 중에서 선택한 1종 이상을 발효 반응하여 다이하드로테스토스테론(dihydrotestosterone) DHT를 차단하여 탈모를 방지하고 콜라겐을 형성하는 약학적 조성물을 수득하는데 그 목적있다 An object of the present invention is to prevent hair loss by fermenting at least one selected from melatonin and dietary sulfur (MSM) ceratin, quercetin, resveratrol, vitamin B6 and vitamin C in coffee and black tea extracts to block dihydrotestosterone DHT. and to obtain a pharmaceutical composition that forms collagen.

본 발명의 또 다른 목적은 수득한 약학적 유효한 성분을 두피에 도포하여 손상된 모낭을 복구하고 발모를 촉진하는데 그 목적있다 Another object of the present invention is to restore damaged hair follicles and promote hair growth by applying the obtained pharmaceutically effective ingredients to the scalp.

본 발명의 또 다른 목적은 수득한 약학적 유효한 조성물을 모발에 도포하여 모발을 갈색으로 염색하는데 그 목적있다 Another object of the present invention is to dye the hair brown by applying the obtained pharmaceutically effective composition to the hair.

본 발명은 커피에 멜라토닌 및 식이유황(MSM) 피세틴,케르세틴, 레스베라트롤 비타민B6를 비타민C를 포함하여 발효 반응한 것으로 생성된 약학적인 유효한 성분을 확보하였다 The present invention secures a pharmaceutically effective ingredient produced by fermentation reaction of melatonin and dietary sulfur (MSM) fisetin, quercetin, and resveratrol vitamin B6 in coffee, including vitamin C.

본 발명의 제 1 조성물은 커피이다 커피추출물에 멜라토닌(Melatonin)0.001중량부~ 10중량부를 포함한 조성물에 식이유황(MSM),레스베라트롤, 세라틴,케르세틴,비타민B6 비타민C 중에서 선택한 1종 이상 0.001중량비~ 10중량부를 포함하고 발효 반응하면 DHT를 차단하여 탈모를 방지하고 모낭에 콜라겐을 형성하며 발모를 촉진하며 동시에 모발을 갈색으로 염색 할 수 있다는 것을 발견하였다 The first composition of the present invention is coffee. In a composition containing 0.001 parts by weight to 10 parts by weight of melatonin in coffee extract, at least one selected from dietary sulfur (MSM), resveratrol, ceratin, quercetin, vitamin B6 and vitamin C 0.001 weight ratio It was found that when it contains ~10 parts by weight and the fermentation reaction is performed, it can block DHT to prevent hair loss, form collagen in hair follicles, promote hair growth, and dye hair brown at the same time.

커피는 꼭두서니과(Rubiaceae)에 속한다 약 200여종의 다양한 품종이 있으며 크게 분류하여 세계 생산량의 70%인 아라비카종(Coffea Arabica)은 카페인을 약1~ 1.2% 생산량의 약 28%인 로부스타종(Coffea Robusta)은 약 1.5~ 2.2% 함유하고 있으며 세계 생산량의 약 1~2%인 리베리카종(Coffea Liberica)으로 분류 할수있다 Coffee belongs to the Rubiaceae family. There are about 200 different varieties, and they are broadly classified. Coffee Arabica, which accounts for 70% of the world's production, contains about 1-1.2% of caffeine, and about 28% of the production, Robusta (Coffea Robusta). ) contains about 1.5 to 2.2% and can be classified as Coffea Liberica, which accounts for about 1 to 2% of the world's production.

커피는 발효 조건이 충분하므로 자연적으로 발효과정(Fermentation)이 발생한다 이과정에서 효소는 커피의 당과 반응하여 분해한다 커피 생두의 성분은 카페인,트리고넬린,불용성 탄수화물, 가용성탄수화물,비휘발성지질,단백질,미네랄,유기산,알칼로이드,클로로겐산,멜라로이딘이다 카페인,클로로겐산,멜라로이딘,트리고넬린은 항염,항균,살충 작용이 우수하다 생두는 가용성탄수화물 약 10g/100g 클로로겐산 약7g/100g 함유하고 있지만 로스팅 후 가용성탄수화물은 약 4g/100g 감소하고 클로로겐산은 약 3g/100 으로 감소하며 항산화 물질인 멜라노이딘은 증가한다 클로로겐산,아미노산,다당류나 자당이 열에 반응한 마이야르 반응(Maillard reaction)으로 생성 된 갈색 색소의 멜라노이딘(melanoidin) 다당류, 자당은, 본 발명의 멜라토닌 비타민6과 반응하여 알콜류를 생성하며 조성물을 두피와 모발에 도포하면 불용성의 염색 작용을 한다 Fermentation occurs naturally in coffee because the conditions for fermentation are sufficient Protein, mineral, organic acid, alkaloid, chlorogenic acid, melaroidin. Caffeine, chlorogenic acid, melaroidin, and trigonelline have excellent anti-inflammatory, antibacterial and insecticidal effects Green beans contain about 10g/100g of soluble carbohydrates and about 7g/100g of chlorogenic acid. After roasting, soluble carbohydrates decrease by about 4g/100g, chlorogenic acid decreases by about 3g/100, and the antioxidant melanoidin increases. of melanoidin polysaccharide, sucrose, reacts with melatonin vitamin 6 of the present invention to produce alcohol, and when the composition is applied to the scalp and hair, it acts as an insoluble dyeing agent

본 발명의 실시에서 사용하는 커피추출액은 예를 들어서 아라비카종이며 로스팅한 커피분말 15g을 투입하여 가압식 에스프레소(Espresso) 머신을 사용하여 약 90도~110도에서 30g의 커피 액체를 추출하여 사용 하였다 용도의 필요에 의하여 커피 생두의 추출액을 사용 할수도 있다 생두를 사용하면 클로로겐산은 유지되고 멜라노이딘은 더 생성되지 않으므로 갈색 색소의 염색성이 감소되는 것을 제외하고 발명이 해결하려는 과제에는 문제점이 발생하지 않는다The coffee extract used in the practice of the present invention is, for example, Arabica type, 15 g of roasted coffee powder was added, and 30 g of coffee liquid was extracted and used at about 90 to 110 degrees using a pressurized espresso machine. If you use green coffee beans, chlorogenic acid is maintained and melanoidin is not produced any more

한편 홍차는 효소에 의해 산화 발효시킴으로써 제조한다 발효정도에 따라 다양하게 분류한다 홍차는 카테킨 탄닌 아미노산 당 지방 미네랄 카페인 비타민B 및 식물성 에스트로겐인 다이드제인이 함유하고 있으며 강력한 항산화성 ,항바이러스성 ,염색성이 있으므로 커피 추출액과 혼합하여 사용 할수 있다 On the other hand, black tea is manufactured by oxidative fermentation by enzymes. It is classified according to the degree of fermentation. Black tea contains catechin, tannin, amino acid, sugar, fat, mineral, caffeine, vitamin B, and daidzein, a phytoestrogens, and has strong antioxidant, antiviral, and dyeing properties. Therefore, it can be used by mixing with coffee extract.

커피추출액 100중량부에 대하여 홍차 1~100중량부를 혼합하여 샤용할수 있으며 바람직하게는 1중령부~ 50중량부이다 홍차 추출액의 포함량이 증가 할수록 커피의 멜라노이딘이 감소하여 갈색의 염색성이 감소한다It can be used by mixing 1 to 100 parts by weight of black tea with respect to 100 parts by weight of the coffee extract, and preferably from 1 to 50 parts by weight.

본 발명 제 2 조성물은 멜라토닌이며The second composition of the present invention is melatonin

상기의 커피 추출액 100 중량부에 멜라토닌 0.001중량부~ 10중량부를 포함시키며 바람직하게는 0.001중량부~ 5중량부를 포함하고 5rpm~30rpm으로 교반하며 1~25도로 14일 이상 발효 반응하고 저온 숙성한다 바람직하게는 30일을 숙성한다 멜라토닌은 수용성이며 열과 적외선 자외선에 노출되면 쉽게 분해 산화되고 약학적 성분이 감소한다 멜라토닌은 소뇌의 윗부분 송과체에서 분비되는 호르몬으로 트립토판(tryptophan)에서 세로토닌을 거쳐 만들어지며 트립토판 아미노산의 카르복실기를 없애고 벤젠고리에 메톡시기를 치환시킨 구조이다 멜라토닌은 수면을 유도하며 활성산소를 제거하는 능력이 탁월하여 항암효과와 인체의 면역기능이 강화되고 노화방지 효과가 있음이 밝혀지고 있다 멜라토닌은 강력한 항균성 항산화성 항염 작용으로 탈모를 방지하고 멜라닌을 조절하며 남성호르몬인 다이하드로테스토스테론(dihydrotestosterone) DHT를 차단하여 탈모를 방지한다 0.001 parts by weight to 10 parts by weight of melatonin are included in 100 parts by weight of the coffee extract, preferably 0.001 parts by weight to 5 parts by weight, stirred at 5 rpm to 30 rpm, fermented at 1 to 25 degrees for 14 days or more, and aged at a low temperature Aging for 30 days Melatonin is water-soluble, easily decomposed and oxidized when exposed to heat and infrared and ultraviolet rays, and its pharmaceutical components are reduced Melatonin is a hormone secreted from the pineal gland in the upper part of the cerebellum. It has a structure in which the carboxyl group is removed and a methoxy group is substituted for the benzene ring. Melatonin induces sleep and has an excellent ability to remove free radicals, so it has been found to have anti-cancer effects, strengthen the immune function of the human body, and have anti-aging effects. It prevents hair loss with strong antibacterial, antioxidant, and anti-inflammatory action, regulates melanin, and blocks dihydrotestosterone DHT, a male hormone to prevent hair loss.

두피의 모낭( hair follicles)에는 멜라토닌 수용체가 있으므로 커피와 멜라토닌 조성물을 두피에 도포하면 모낭에 있는 멜라토닌 수용체와 작용하여 손상된 모낭과 모근을 복구시키고 염증을 치료하며 탈모를 예방하고 검은머리 발모를 촉진한다 Since there are melatonin receptors in the hair follicles of the scalp, when coffee and a melatonin composition are applied to the scalp, it works with the melatonin receptors in the hair follicles to restore damaged hair follicles and hair roots, treat inflammation, prevent hair loss, and promote dark hair growth.

멜라토닌은 글루타치온 비타민C 비타민E 보다 강력한 산화방지 작용을 하며 모낭의콜라겐을 생성한다 종래의 비타민들은 세포나 세포기관으로 쉽게 들어가지 못하지만 멜라토닌은 세포의 모든 부분을 자유스럽게 이동하며 DNA를 활성 산소로부터 보호하고 손상된 DNA를 치료하고 피부노화를 억제한다 멜라토닌의 약학적인 유효한 작용은 수많은 연구에 의하여 확인되고 있다 Melatonin has a stronger antioxidant action than glutathione vitamin C and vitamin E and produces collagen in the hair follicle. Conventional vitamins do not easily enter cells or organelles, but melatonin moves freely through all parts of the cell and protects DNA from free radicals. It treats damaged DNA and inhibits skin aging. The effective pharmacological action of melatonin has been confirmed by numerous studies.

본 발명 제 3조성물은 식이유황(MSM)이다 MSM은 피부와 모발을 구성하는 단백질을 만드는 물질이며 모발의 케라틴과 두피의 콜라겐을 생성하는 작용을 한다 혈류를 증가시키고, 탈모를 방지하고 발모를 촉진도 시키는 작용을 한다 The third composition of the present invention is dietary sulfur (MSM). MSM is a substance that makes proteins constituting the skin and hair, and acts to produce keratin of hair and collagen of the scalp Increase blood flow, prevent hair loss, and promote hair growth also acts to

제4조성물은 레스베라트롤(Resveratrol)이다 레스베라트롤(Resveratrol)은 파이토알렉신으로서 폴리페놀계 물질이며 항바이러스성, 항산화성,항염성이 있다 탈아세틸효소를 활성화시켜 항노화 작용을하며 퀴논 환원효소(QR1)와 사이클로옥시제나제(COX)를 억제한다. 레드와인에 많이 포함되 있다The 4th composition is resveratrol. Resveratrol is a phytoalexin, a polyphenolic substance, and has antiviral, antioxidant, and anti-inflammatory properties. It has anti-aging action by activating deacetylase and quinone reductase (QR1) ) and cyclooxygenase (COX). Red wine contains a lot of

제5조성물은 피세틴(Fisetin)이다 피세틴은 항균성,항염성, 항산화성 및 특히 노화세포를 제거하는 작용이 탁월하여 백혈병 치료제인 다사티닙(dasatinib)과 함께 사용하여 노화세포를 제거하는 칵테일 요법의 항노화 물질로 연구되고 있다 피세틴은 딸기, 망고, 오이 및 과일과 야채에서 발견되는 식물성 플라보노이드로 화학구조가 퀘르세틴과 비슷하며 혼합하여 사용하면 약학적인 유익한 작용은 증가한다 Composition 5 is Fisetin. Fisetin is a cocktail that removes senescent cells when used together with dasatinib, a leukemia treatment, as it has excellent antibacterial, anti-inflammatory, antioxidant and, in particular, action to remove senescent cells. It is being studied as an anti-aging agent for therapy. Ficetin is a phytoflavonoid found in strawberries, mango, cucumber, and fruits and vegetables. Its chemical structure is similar to that of quercetin.

본 발명의 제 6조성물은 퀘르세틴(Quercetin)이다 퀘르세틴은 적포도주,사과, 자두, 적포도, 녹차, 엘더플라워 및 양파에 존제하는 항산화성 플라보노이드 이다 퀘르세린의 강력한 항염성 항산화성 항바이러스 작용은 감기와 독감을 예방 치료하며 면역력을 높이고 염증을 퇴치한다 특히 인체의 노화된 상피세포와 골수 줄기 세포를 제거하는 항노화 작용을 한다 2016년 사이언티픽 리포트(Scientific Reports) 발표에 따르면, 퀘르세틴에는 DNA와 상호 작용하고 세포 자연사의 미토콘드리아 경로를 활성화함으로써 종양을 치료하는 효과가 밝혀지고 있으며 피세틴과 칵테일요법으로 사용하면 노화세포를 제거하는 능력이 증가한다 The sixth composition of the present invention is quercetin. Quercetin is an antioxidant flavonoid present in red wine, apple, plum, red grape, green tea, elderflower and onion. Prevents flu, boosts immunity and fights inflammation. In particular, it has anti-aging action by removing senescent epithelial cells and bone marrow stem cells from the body. And the effect of treating tumors by activating the mitochondrial pathway of natural cell death is being revealed.

제 7조성물은 비타민B6 이다 수용성이며 피리독신 피리독살 피리독사민 및 이들의 인산 에스테르를 합한 총칭을 말하며 탄수화물 지방의 대사에 작용하여 인체의 60여가지 효소의 정상 기능과 호르몬의 균형을 맞춰준다 세로토닌과 도파민 노르에피네프린 등의 신경 전달 물질합성과 멜라토닌과 단백질의 합성 및 피부와 모발 점막유지와 인체 대사 기능에 작용하고 피부질환을 예방하고 치료하며 노화를 방지하는 핵산의 합성을 촉진한다 The 7th composition is vitamin B6. Water-soluble, pyridoxine pyridoxal pyridoxamine and their phosphoric acid esters. It acts on the metabolism of carbohydrates and fats to balance the normal functions of 60 enzymes and hormones in the human body. Synthesis of neurotransmitters such as dopamine and norepinephrine, synthesis of melatonin and protein, maintenance of skin and hair mucosa and metabolic function of the human body, and promotes the synthesis of nucleic acids that prevent and treat skin diseases and prevent aging

제8조성물은 비타민C 이다 비타민 C( L-ascorbic acid, Asc)는 비타민의 한 종류이다. 인체에서 비타민C가 결핍되면 괴혈병이 발생한다. 콜라겐의 합성에 작용한다 Article 8 Composition is vitamin C Vitamin C (L-ascorbic acid, Asc) is a type of vitamin. A deficiency of vitamin C in the body causes scurvy. Acts on the synthesis of collagen

본 발명은 커피 생두 또는 로스팅한 커피 추출물에 홍차 추출물 1중량부~ 100중량부를 혼합 사용할 수 있으며 추출물 100 중량부에 대하여 멜라토닌 0.001중량부~10중량부를 포함하고 식이유황(MSM) 레스베라트롤(Resveratrol)피세틴(Fisetin)케르세틴(Quercetin) 비타민B6 비타민C 중에서 선택한 1종 이상을 0.001중량부~~10중량부을 포함하여 발효 반응하여 생성된 약학적 유효한 조성물에 관한 것이다 According to the present invention, 1 part by weight to 100 parts by weight of black tea extract can be mixed with green coffee beans or roasted coffee extract, and 0.001 parts by weight to 10 parts by weight of melatonin based on 100 parts by weight of the extract, and dietary sulfur (MSM) resveratrol blood It relates to a pharmaceutically effective composition produced by fermentation reaction including 0.001 parts by weight to 10 parts by weight of at least one selected from among cetin (Fisetin) and quercetin (Quercetin) vitamin B6 and vitamin C.

통상 커피의 카페인 함유량은 아라비카 품종 약1~ 1.2% 로부스타 품종 약1.5~ 2.2%이며 홍차의 카페인 함유량은 약3~3.3%이다 키페인은 항염성, 항산화성 및 남성호르몬인 테스토스테론(testosterone) 을 억제하여 탈모를 방지하는 작용을 하므로 본 발명의 커피와 멜라토닌을 유효성분으로 생성된 염모제 및 약학적 조성물은두피와 모발 건강에 유익한 작용을 한다 Typically, the caffeine content of coffee is about 1-1.2% of Arabica varieties, about 1.5-2.2% of Robusta varieties, and the caffeine content of black tea is about 3-3.3%. Thus, it acts to prevent hair loss, so the hair dye and pharmaceutical composition produced with coffee and melatonin of the present invention as active ingredients have a beneficial effect on scalp and hair health

본 발명 조성물은 자외선과 적외선에 산화되므로 자외선과 적외선이 차단된 1LX -1000LX의 LED 빛을 조사하며 발효 반응으로 생성된 약학적 유효한 조성물을 수득하는 것이 바람직하다 수득한 조성물은 수용성이며 비중0.8~1.5 점도 1cp~ 7cp이므로 피부와 두피 모발에 분사 도포가 용이하며 필요에 의하여 증류수를 첨가하여 점도와 밀도를 조절할 수 있다 분사 도포하는 방법은 용기에 발효조성물과 압축공기 또는 압축가스를 충진한 에어로젤 방법, 통상적인 스프레이방법, 손으로 바르는 방법으로 선택하여 피부와 두피와 모발에 조성물을 도포 할 수 있다Since the composition of the present invention is oxidized by ultraviolet and infrared rays, it is preferable to obtain a pharmaceutically effective composition produced by fermentation reaction by irradiating 1LX -1000LX LED light that blocks ultraviolet and infrared rays. The obtained composition is water-soluble and has a specific gravity of 0.8 to 1.5 Since the viscosity is 1 cp to 7 cp, it is easy to spray and apply to the skin and scalp and hair, and if necessary, add distilled water to adjust the viscosity and density. The composition can be applied to the skin, scalp and hair by selecting the usual spray method or hand application method.

본 발명은 종래의 발명에서 제안되지 않은 신규한 것으로 커피,홍차 추출액에 멜라토닌(Melatonin) 및 식이유황(MSM) 레스베라트롤(Resveratrol)피세틴(Fisetin) 케르세틴(Quercetin) 비타민B 6 비타민C 중에서 선택한 1종 단독 또는 2종 이상을 포함하고 발효 반응하여 생성된 약학적 유효 한 조성물을 수득한 것으로, 두피와 두발에 도포하여 남성호르몬인 DHT를 차단하며 콜라겐을 생성하여 손상된 모낭을 회복하고 탈모방지 발모촉진 및 염색을 할수 있으므로 두피 질병의 예방과 치료 노화방지에 기여할수 있다 The present invention is a novelty that has not been proposed in the prior invention, and one selected from melatonin and dietary sulfur (MSM) resveratrol, fisetin, quercetin, vitamin B 6 and vitamin C in coffee and tea extracts To obtain a pharmaceutically effective composition containing alone or two or more types and produced by fermentation reaction, it is applied to the scalp and hair to block DHT, a male hormone, and generate collagen to restore damaged hair follicles, prevent hair loss, promote hair growth and Because it can be dyed, it can contribute to the prevention and treatment of scalp diseases and anti-aging.

이하 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다 The present invention will be described in more detail with reference to the following examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples.

실시예 1 Example 1

1.커피추출액 100중량부에 멜라토닌 0.001중량부~~5중량부를 포함하고 상층부가 투명 아크릴로 설치된 밀폐형 리본형 교반기에 투입하여 산소 공급을 차단하고 온도를 1~25도로 조절하며 5~30rpm으로 30~360분 교반하여 멜라토닌을 용해하고 1 LX- 100 LX 로 LED 빛을 조사하였다1. In 100 parts by weight of coffee extract, 0.001 parts by weight to 5 parts by weight of melatonin is put into a closed ribbon stirrer with the upper layer installed with transparent acrylic to cut off oxygen supply, adjust the temperature to 1 to 25 degrees, and 30 at 5 to 30 rpm. Melatonin was dissolved by stirring for ~360 minutes, and LED light was irradiated with 1 LX-100 LX.

2.발효 숙성 장소의 환경을 1-25℃로 조절하였고 14일 후 효모가 작용하고 조성물이 발효 반응 하였다2. Fermentation The environment of the aging place was adjusted to 1-25℃, and after 14 days, yeast worked and the composition was fermented.

3. 조성물을 공기압축형 에어로젤 스프레이 용기에 충진였다3. The composition was filled in an air-compressed airgel spray container.

실시예 2Example 2

실시예 1과 동일하게 실시하되 커피추출물 50중량부에 홍차 추출물 50중량부를 혼합 사용하였다It was carried out in the same manner as in Example 1, except that 50 parts by weight of the coffee extract was mixed with 50 parts by weight of the black tea extract.

실시예3Example 3

1.실시예 1과2와 동일하게 실시하되 식이유황(MSM) 레스베라트롤(Resveratrol) 피세틴(Fisetin) 케르세틴(Quercetin) 비타민B 6 비타민C 중에서 선택한 1종 이상을 0.001중량부~5중량부를 포함하였다 1. It was carried out in the same manner as in Examples 1 and 2, but it contained 0.001 parts by weight to 5 parts by weight of at least one selected from dietary sulfur (MSM) resveratrol, fisetin, quercetin, vitamin B 6 and vitamin C.

2.조성물을 공기압축형 에어로젤 스프레이 용기에 충진하였다 2. The composition was filled in an air compressed airgel spray container.

Claims (6)

커피 추출물 100중량부에 대하여 멜라토닌과 그 유도체 0.001중량부~10중량부를 포함하고 발효 반응하여 다이하드로테스토스테론(dihydrotestosterone)을 차단하고 콜라겐을 형성하는 염모제 및 약학적 조성물 A hair dye and pharmaceutical composition containing 0.001 parts by weight to 10 parts by weight of melatonin and its derivatives based on 100 parts by weight of the coffee extract and blocking dihydrotestosterone and forming collagen by fermentation reaction 커피와 홍차의 혼합 추출물 100중량부에 대하여 멜라토닌과 그 유도체 0.001중량부~10중량부를 포함하고 발효 반응하여 다이하드로테스토스테론(dihydrotestosterone)을 차단하고 콜라겐을 형성하는 염모제 및 약학적 조성물 A hair dye and pharmaceutical composition containing 0.001 parts by weight to 10 parts by weight of melatonin and its derivatives based on 100 parts by weight of the mixed extract of coffee and black tea, and blocking dihydrotestosterone and forming collagen by fermentation reaction 제 1항에 있어서 식이유황 레스베라트롤 피세틴 케르세틴 비타민B 6 비타민C 중에서 선택한 1종 이상을 0.001중량부~10중량부 포함하여 발효 반응하여 다이하드로테스토스테론(dihydrotestosterone)을 차단하고 콜라겐을 형성하는 염모제 및 약학적 조성물 The method according to claim 1, wherein the fermentation reaction contains 0.001 to 10 parts by weight of one or more selected from dietary sulfur resveratrol fisetin, quercetin, vitamin B, and vitamin C, and a hair dye that blocks dihydrotestosterone and forms collagen; pharmaceutical composition 제 2항에 있어서 식이유황 레스베라트롤 피세틴 케르세틴 비타민B 6 비타민C 중에서 선택한 1종 이상을 0.001중량부~10중량부 포함하여 발효 반응하여 다이하드로테스토스테론(dihydrotestosterone)을 차단하고 콜라겐을 형성하는 염모제 및 약학적 조성물 The method according to claim 2, wherein the fermentation reaction contains 0.001 to 10 parts by weight of one or more selected from dietary sulfur resveratrol fisetin, quercetin, vitamin B 6, vitamin C, and a hair dye that blocks dihydrotestosterone and forms collagen; pharmaceutical composition 1.커피추출액 100중량부에 멜라토닌 0.001중량부~~5중량부를 포함하고 상층부가 투명 아크릴로 설치된 밀폐형 리본형 교반기에 투입하여 산소 공급을 차단하고 온도를 1~25도로 조절하며 5~30rpm으로 30~360분 교반하여 멜라토닌을 용해하며 1 LX- 100 LX 로 LED 빛을 조사하는 단계
2.발효반응 숙성 장소의 환경을 1-25℃로 조절하며 5~30rpm으로 교반하였고 효모가 작용하고 조성물이 발효 반응하는 단계로
3.조성물을 공기압축형 에어로젤 스프레이 용기에 충진하는 단계로 수득한 다이하드로테스토스테론(dihydrotestosterone)을 차단하고 콜라겐을 형성하는 염모제 및 약학적 조성물1. In 100 parts by weight of coffee extract, 0.001 parts by weight to 5 parts by weight of melatonin is put into a closed ribbon stirrer with the upper layer installed with transparent acrylic to cut off oxygen supply, adjust the temperature to 1 to 25 degrees, and 30 at 5 to 30 rpm. Dissolving melatonin by stirring for ~360 minutes and irradiating LED light with 1 LX-100 LX
2. Fermentation reaction The environment of the aging place was adjusted to 1-25℃, stirred at 5~30rpm, yeast acts and the composition is fermented.
3. A hair dye and pharmaceutical composition that blocks dihydrotestosterone and forms collagen obtained by filling the composition into an air-compressed airgel spray container 1.커피추출액 100중량부에 멜라토닌 0.001중량부~~5중량부를 포함하는 단계
2.식이유황(MSM) 레스베라트롤 피세틴 케르세틴 비타민B 6 비타민C 중에서 선택한 1종 이상을 0.001중량부~10중량부 포함하는 단계
3.상층부가 투명 아크릴로 설치된 밀폐형 리본형 교반기에 투입하여 산소 공급을 차단하고 온도를 1~25도로 조절하며 5~30rpm으로 30~360분 교반하여 조성물을 용해하며 1 LX- 100 LX 로 LED 빛을 조사하는 단계
4.발효반응 숙성 장소의 환경을 1-25℃로 조절하며 5~30rpm으로 교반하였고 효모가 작용하고 조성물이 발효 반응하는 단계
5.조성물을 공기압축형 에어로젤 스프레이 용기에 충진하는 단계로 수득한 다이하드로테스토스테론(dihydrotestosterone)을 차단하고 콜라겐을 형성하는 염모제 및 약학적 조성물

















1. Containing 0.001 parts by weight to 5 parts by weight of melatonin in 100 parts by weight of the coffee extract
2. Dietary sulfur (MSM), resveratrol fisetin, quercetin, vitamin B 6, and at least one selected from vitamin C, including 0.001 parts by weight to 10 parts by weight
3. Put the upper layer into a closed ribbon stirrer installed with transparent acrylic to cut off oxygen supply, adjust the temperature to 1 to 25 degrees, stir at 5 to 30 rpm for 30 to 360 minutes to dissolve the composition, and use 1 LX-100 LX of LED light steps to investigate
4. Fermentation reaction A step in which the environment of the aging place is adjusted to 1-25°C and stirred at 5-30rpm, yeast acts and the composition is fermented
5. A hair dye and pharmaceutical composition that blocks dihydrotestosterone and forms collagen obtained by filling the composition into an air-compressed airgel spray container
KR1020200097090A 2020-08-04 2020-08-04 a hair dye and medicinal composition made from coffee and melatonin as an active ingredient KR20220017537A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110060379A (en) 2009-11-30 2011-06-08 (주)아모레퍼시픽 Hair dye composition comprising catechin
KR101809561B1 (en) 2016-06-10 2018-01-18 임명기 Hair dye composition comprising coffee extract, amla powder and Dioscorea batatas extract and manufacturing method thereof
KR20180092528A (en) 2017-02-09 2018-08-20 손은경 Method for preparing hair dyeing composition containing coffee ground extracts
KR102014680B1 (en) 2019-04-09 2019-10-21 송은나 Method for Operation Dyeing of Hair Using Hair Dye Composition
KR20190135106A (en) 2018-05-28 2019-12-06 이숙희 Hair dye using nature materials

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110060379A (en) 2009-11-30 2011-06-08 (주)아모레퍼시픽 Hair dye composition comprising catechin
KR101809561B1 (en) 2016-06-10 2018-01-18 임명기 Hair dye composition comprising coffee extract, amla powder and Dioscorea batatas extract and manufacturing method thereof
KR20180092528A (en) 2017-02-09 2018-08-20 손은경 Method for preparing hair dyeing composition containing coffee ground extracts
KR20190135106A (en) 2018-05-28 2019-12-06 이숙희 Hair dye using nature materials
KR102014680B1 (en) 2019-04-09 2019-10-21 송은나 Method for Operation Dyeing of Hair Using Hair Dye Composition

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