KR20210132003A - 변형된 오르토폭스 바이러스 벡터 - Google Patents

변형된 오르토폭스 바이러스 벡터 Download PDF

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KR20210132003A
KR20210132003A KR1020217022872A KR20217022872A KR20210132003A KR 20210132003 A KR20210132003 A KR 20210132003A KR 1020217022872 A KR1020217022872 A KR 1020217022872A KR 20217022872 A KR20217022872 A KR 20217022872A KR 20210132003 A KR20210132003 A KR 20210132003A
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nucleotide sequence
transgene
promoter
nucleic acid
gene
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존 씨. 벨
마이클 에스. 허
매튜 와이. 탕
애드리안 펠린
캐롤라인 제이. 브라이트바흐
마이클 에프. 버지스
스티븐 에이치. 번스타인
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오타와 하스피털 리서치 인스티튜트
턴스톤 바이오로직스 코포레이션
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Publication of KR20210132003A publication Critical patent/KR20210132003A/ko
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020217022872A 2018-12-21 2019-12-20 변형된 오르토폭스 바이러스 벡터 Ceased KR20210132003A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862784372P 2018-12-21 2018-12-21
US62/784,372 2018-12-21
US201962872699P 2019-07-10 2019-07-10
US62/872,699 2019-07-10
US201962930524P 2019-11-04 2019-11-04
US62/930,524 2019-11-04
PCT/CA2019/051899 WO2020124274A1 (en) 2018-12-21 2019-12-20 Modified orthopoxvirus vectors

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KR20210132003A true KR20210132003A (ko) 2021-11-03

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KR1020217022872A Ceased KR20210132003A (ko) 2018-12-21 2019-12-20 변형된 오르토폭스 바이러스 벡터
KR1020217022871A Ceased KR20210132002A (ko) 2018-12-21 2019-12-20 변형된 오르토폭스 바이러스 벡터

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US (2) US20220056480A1 (enExample)
EP (2) EP3898997A4 (enExample)
JP (2) JP2022514420A (enExample)
KR (2) KR20210132003A (enExample)
CN (2) CN113661246A (enExample)
AU (2) AU2019404639A1 (enExample)
BR (2) BR112021012078A2 (enExample)
CA (2) CA3124301A1 (enExample)
CL (1) CL2021001646A1 (enExample)
CO (1) CO2021009354A2 (enExample)
EC (1) ECSP21053474A (enExample)
IL (2) IL284180A (enExample)
MX (2) MX2021007438A (enExample)
PE (1) PE20212307A1 (enExample)
PH (1) PH12021551436A1 (enExample)
SG (1) SG11202106460XA (enExample)
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US10612005B2 (en) 2016-01-08 2020-04-07 Replimune Limited Modified oncolytic virus
JP7724601B2 (ja) 2017-02-03 2025-08-18 ユニバーシティ オブ ピッツバーグ －オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 腫瘍溶解性ウイルス療法
SG11202006457YA (en) 2018-01-05 2020-08-28 Ottawa Hospital Res Inst Modified orthopoxvirus vectors
EP4061417A4 (en) * 2019-11-20 2023-10-11 University of Pittsburgh - of the Commonwealth System of Higher Education VACCINIA VIRUSES AND METHOD FOR USING VACCINIA VIRUSES
JP6915792B1 (ja) * 2020-10-01 2021-08-04 国立大学法人鳥取大学 広範囲遺伝子欠損を有する腫瘍溶解性ワクシニアウイルス
WO2023106839A1 (ko) * 2021-12-07 2023-06-15 재단법인 아산사회복지재단 Il-12를 발현하는 재조합 백시니아 바이러스 및 이의 용도
JP2025503721A (ja) * 2022-01-17 2025-02-04 ノイスコム アーゲー がん治療用免疫刺激タンパク質をコードする組換えオルソポックスウイルスベクター
CN119677861A (zh) * 2022-06-10 2025-03-21 特兰斯吉恩股份有限公司 表达白介素-12的重组病毒
IL318055A (en) * 2022-07-08 2025-02-01 Viromissile Inc ONCOLYTIC VACCINIA VIRUSES AND RECOMBINANT VIRUSES AND METHODS OF USE THEREOF
CN119923267A (zh) * 2022-07-27 2025-05-02 阿斯利康(瑞典)有限公司 表达白介素-12的重组病毒与pd-1/pd-l1抑制剂的组合
CN115947797B (zh) * 2022-08-02 2024-07-05 青岛硕景生物科技有限公司 猴痘病毒重组抗原及其应用
WO2024130212A1 (en) 2022-12-16 2024-06-20 Turnstone Biologics Corp. Recombinant vaccinia virus encoding one or more natural killer cell and t lymphocyte inhibitors
CN116200349A (zh) * 2023-01-18 2023-06-02 中国医学科学院病原生物学研究所 一种基于改良痘苗病毒天坛株的新型冠状病毒疫苗
CN115927215B (zh) * 2023-01-18 2025-10-17 中国医学科学院病原生物学研究所 一种定向减毒的痘苗病毒疫苗
CN118240879A (zh) * 2023-11-01 2024-06-25 上海市重大传染病和生物安全研究院 骨架质粒、重组质粒以及猴痘病毒颗粒和应用
WO2026047314A1 (en) * 2024-08-28 2026-03-05 University Of Surrey Recombinant vector

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ES2150495T5 (es) * 1993-05-19 2007-02-16 Schering Corporation Ligandos de flt3 purificados de mamifero y agonistas y antagonistas de los mismos.
KR20120002613A (ko) * 2002-08-12 2012-01-06 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
AU2003290528A1 (en) * 2002-10-15 2004-05-04 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods and reagents for inducing immunity
RU2503717C2 (ru) * 2007-11-19 2014-01-10 Трансжене Са Поксвирусные онколитические векторы
RS65104B1 (sr) * 2013-08-22 2024-02-29 Univ Pittsburgh Commonwealth Sys Higher Education Onkolitičke imunoterapije
RU2696312C2 (ru) * 2014-07-16 2019-08-01 Трансген Са Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек
CN106520778A (zh) * 2015-09-09 2017-03-22 北京锤特生物科技有限公司 改造的白介素12及其在制备治疗肿瘤的药物中的用途
WO2018049248A1 (en) * 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus equipped with bispecific engager molecules
SG11202006457YA (en) * 2018-01-05 2020-08-28 Ottawa Hospital Res Inst Modified orthopoxvirus vectors

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EP3898997A1 (en) 2021-10-27
WO2020124273A1 (en) 2020-06-25
WO2020124274A1 (en) 2020-06-25
IL284180A (en) 2021-08-31
CO2021009354A2 (es) 2021-11-19
AU2019410148A1 (en) 2021-08-12
US20220056480A1 (en) 2022-02-24
BR112021011730A2 (pt) 2021-08-31
TW202039851A (zh) 2020-11-01
CL2021001646A1 (es) 2022-02-18
EP3898998A4 (en) 2022-10-05
US20220380799A1 (en) 2022-12-01
IL284188A (en) 2021-08-31
MX2021007439A (es) 2021-08-05
EP3898997A4 (en) 2022-11-16
BR112021012078A2 (pt) 2021-08-31
ECSP21053474A (es) 2021-11-18
AU2019404639A1 (en) 2021-08-12
EP3898998A1 (en) 2021-10-27
KR20210132002A (ko) 2021-11-03
PE20212307A1 (es) 2021-12-10
CN113661246A (zh) 2021-11-16
CA3124287A1 (en) 2020-06-25
MX2021007438A (es) 2021-09-21
JP2022514420A (ja) 2022-02-10
JP2022516006A (ja) 2022-02-24
CA3124301A1 (en) 2020-06-25
PH12021551436A1 (en) 2021-12-06
SG11202106460XA (en) 2021-07-29
CN113454231A (zh) 2021-09-28

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