KR20210125990A - 단백질 대체 치료 양식을 운반하기 위한 아넬로좀 - Google Patents

단백질 대체 치료 양식을 운반하기 위한 아넬로좀 Download PDF

Info

Publication number
KR20210125990A
KR20210125990A KR1020217021776A KR20217021776A KR20210125990A KR 20210125990 A KR20210125990 A KR 20210125990A KR 1020217021776 A KR1020217021776 A KR 1020217021776A KR 20217021776 A KR20217021776 A KR 20217021776A KR 20210125990 A KR20210125990 A KR 20210125990A
Authority
KR
South Korea
Prior art keywords
nucleic acid
sequence
anellosome
genetic element
orf1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020217021776A
Other languages
English (en)
Korean (ko)
Inventor
에리카 가브리엘 와인스타인
아박 카베지안
사이먼 델라그레이브
네이슨 로렌스 요즈위악
케빈 제임스 레보
페르난도 마틴 디아즈
다난제이 마니클랄 나완다르
라이언 디. 테드스톤
재러드 데이비드 피츠
Original Assignee
플래그쉽 파이어니어링 이노베이션스 브이, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 플래그쉽 파이어니어링 이노베이션스 브이, 인크. filed Critical 플래그쉽 파이어니어링 이노베이션스 브이, 인크.
Publication of KR20210125990A publication Critical patent/KR20210125990A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1020217021776A 2018-12-12 2019-12-12 단백질 대체 치료 양식을 운반하기 위한 아넬로좀 Pending KR20210125990A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862778866P 2018-12-12 2018-12-12
US201862778861P 2018-12-12 2018-12-12
US62/778,861 2018-12-12
US62/778,866 2018-12-12
PCT/US2019/065963 WO2020123795A2 (en) 2018-12-12 2019-12-12 Anellosomes for delivering protein replacement therapeutic modalities

Publications (1)

Publication Number Publication Date
KR20210125990A true KR20210125990A (ko) 2021-10-19

Family

ID=69160356

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217021776A Pending KR20210125990A (ko) 2018-12-12 2019-12-12 단백질 대체 치료 양식을 운반하기 위한 아넬로좀

Country Status (11)

Country Link
US (1) US20220073950A1 (https=)
EP (1) EP3894569A2 (https=)
JP (2) JP2022513459A (https=)
KR (1) KR20210125990A (https=)
CN (1) CN114127303A (https=)
AU (1) AU2019395418A1 (https=)
BR (1) BR112021010925A2 (https=)
CA (1) CA3119814A1 (https=)
IL (1) IL283781A (https=)
MX (1) MX2021006945A (https=)
WO (1) WO2020123795A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018256925B2 (en) 2017-04-28 2024-11-21 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
BR112021011124A2 (pt) * 2018-12-12 2022-03-15 Flagship Pioneering Innovations V Inc Anelossomos e métodos de uso
AU2021288320A1 (en) * 2020-06-12 2023-01-19 Flagship Pioneering Innovations V, Inc. Tandem anellovirus constructs
JP2023530451A (ja) * 2020-06-17 2023-07-18 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド アネロウイルスを同定し及び特徴付ける方法並びにその使用
EP4267157A4 (en) * 2020-12-23 2025-05-07 Flagship Pioneering Innovations V, Inc. IN VITRO ASSEMBLY OF ANELLOVIRUS CAPSIDS WITH RNA
EP4415695A4 (en) * 2021-10-12 2025-11-26 Flagship Pioneering Innovations V Inc NEW ANELLOVECTOR COMPOSITIONS AND METHODS
US20250027107A1 (en) 2021-10-18 2025-01-23 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
TW202529819A (zh) 2023-10-13 2025-08-01 美商旗艦先鋒創新公司 組織特異性指環載體(anellovector)遞送

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9002008A (nl) * 1990-09-12 1992-04-01 Stichting Centr Diergeneeskund Recombinant dna en rna en daarvan afgeleide produkten.
US6395472B1 (en) * 1999-02-05 2002-05-28 Abbott Laboratories Methods of utilizing the TT virus
US9676828B2 (en) * 2010-06-23 2017-06-13 Deutsches Krebsforschungszentrum Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity
IL271275B1 (en) * 2017-06-13 2026-04-01 Flagship Pioneering Innovations V Inc Preparations containing croons and their uses
KR20210131309A (ko) * 2018-12-12 2021-11-02 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 분비형 치료 양식을 운반하기 위한 아넬로좀
BR112021011124A2 (pt) * 2018-12-12 2022-03-15 Flagship Pioneering Innovations V Inc Anelossomos e métodos de uso
WO2020123753A2 (en) * 2018-12-12 2020-06-18 Flagship Pioneering Innovations V, Inc. Anellosomes for delivering intracellular therapeutic modalities

Also Published As

Publication number Publication date
IL283781A (en) 2021-07-29
CA3119814A1 (en) 2020-06-18
WO2020123795A3 (en) 2020-08-27
BR112021010925A2 (pt) 2021-08-31
WO2020123795A2 (en) 2020-06-18
EP3894569A2 (en) 2021-10-20
CN114127303A (zh) 2022-03-01
AU2019395418A1 (en) 2021-06-03
US20220073950A1 (en) 2022-03-10
JP2022513459A (ja) 2022-02-08
JP2024099833A (ja) 2024-07-25
MX2021006945A (es) 2021-08-24

Similar Documents

Publication Publication Date Title
US11446344B1 (en) Anellovirus compositions and methods of use
KR20210131309A (ko) 분비형 치료 양식을 운반하기 위한 아넬로좀
KR20210125990A (ko) 단백질 대체 치료 양식을 운반하기 위한 아넬로좀
KR20210131310A (ko) 아넬로좀 및 사용 방법
US20190211361A1 (en) Compositions comprising curons and uses thereof
KR20210131308A (ko) 세포내 치료 양식을 운반하기 위한 아넬로좀
KR20230036109A (ko) 바큘로바이러스 발현 시스템
KR20230041686A (ko) 아넬로바이러스를 확인 및 특징화하는 방법 및 이의 용도
KR20230036110A (ko) 탠덤 아넬로바이러스 구축물
KR20230146560A (ko) 하이브리드 aav-아넬로벡터
KR20230124682A (ko) Rna를 봉입하는 아넬로바이러스 캡시드의 시험관 내어셈블리

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

D21 Rejection of application intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902