CN114127303A - 用于递送蛋白质替代治疗方式的指环体 - Google Patents

用于递送蛋白质替代治疗方式的指环体 Download PDF

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Publication number
CN114127303A
CN114127303A CN201980091248.4A CN201980091248A CN114127303A CN 114127303 A CN114127303 A CN 114127303A CN 201980091248 A CN201980091248 A CN 201980091248A CN 114127303 A CN114127303 A CN 114127303A
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nucleic acid
sequence
ring body
genetic element
orf1
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Pending
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CN201980091248.4A
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English (en)
Chinese (zh)
Inventor
E.G.韦因斯坦
A.卡韦吉安
S.德拉格雷夫
N.L.尤兹维亚克
K.J.莱博
F.M.迪亚兹
D.M.纳万达
R.D.泰德斯通
J.D.皮茨
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Flagship Pioneering Innovations V Inc
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Flagship Pioneering Innovations V Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN201980091248.4A 2018-12-12 2019-12-12 用于递送蛋白质替代治疗方式的指环体 Pending CN114127303A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862778866P 2018-12-12 2018-12-12
US201862778861P 2018-12-12 2018-12-12
US62/778,861 2018-12-12
US62/778,866 2018-12-12
PCT/US2019/065963 WO2020123795A2 (en) 2018-12-12 2019-12-12 Anellosomes for delivering protein replacement therapeutic modalities

Publications (1)

Publication Number Publication Date
CN114127303A true CN114127303A (zh) 2022-03-01

Family

ID=69160356

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980091248.4A Pending CN114127303A (zh) 2018-12-12 2019-12-12 用于递送蛋白质替代治疗方式的指环体

Country Status (11)

Country Link
US (1) US20220073950A1 (https=)
EP (1) EP3894569A2 (https=)
JP (2) JP2022513459A (https=)
KR (1) KR20210125990A (https=)
CN (1) CN114127303A (https=)
AU (1) AU2019395418A1 (https=)
BR (1) BR112021010925A2 (https=)
CA (1) CA3119814A1 (https=)
IL (1) IL283781A (https=)
MX (1) MX2021006945A (https=)
WO (1) WO2020123795A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018256925B2 (en) 2017-04-28 2024-11-21 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
BR112021011124A2 (pt) * 2018-12-12 2022-03-15 Flagship Pioneering Innovations V Inc Anelossomos e métodos de uso
AU2021288320A1 (en) * 2020-06-12 2023-01-19 Flagship Pioneering Innovations V, Inc. Tandem anellovirus constructs
JP2023530451A (ja) * 2020-06-17 2023-07-18 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド アネロウイルスを同定し及び特徴付ける方法並びにその使用
EP4267157A4 (en) * 2020-12-23 2025-05-07 Flagship Pioneering Innovations V, Inc. IN VITRO ASSEMBLY OF ANELLOVIRUS CAPSIDS WITH RNA
EP4415695A4 (en) * 2021-10-12 2025-11-26 Flagship Pioneering Innovations V Inc NEW ANELLOVECTOR COMPOSITIONS AND METHODS
US20250027107A1 (en) 2021-10-18 2025-01-23 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
TW202529819A (zh) 2023-10-13 2025-08-01 美商旗艦先鋒創新公司 組織特異性指環載體(anellovector)遞送

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018232017A1 (en) * 2017-06-13 2018-12-20 Flagship Pioneering, Inc. Compositions comprising curons and uses thereof

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NL9002008A (nl) * 1990-09-12 1992-04-01 Stichting Centr Diergeneeskund Recombinant dna en rna en daarvan afgeleide produkten.
US6395472B1 (en) * 1999-02-05 2002-05-28 Abbott Laboratories Methods of utilizing the TT virus
US9676828B2 (en) * 2010-06-23 2017-06-13 Deutsches Krebsforschungszentrum Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity
KR20210131309A (ko) * 2018-12-12 2021-11-02 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 분비형 치료 양식을 운반하기 위한 아넬로좀
BR112021011124A2 (pt) * 2018-12-12 2022-03-15 Flagship Pioneering Innovations V Inc Anelossomos e métodos de uso
WO2020123753A2 (en) * 2018-12-12 2020-06-18 Flagship Pioneering Innovations V, Inc. Anellosomes for delivering intracellular therapeutic modalities

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018232017A1 (en) * 2017-06-13 2018-12-20 Flagship Pioneering, Inc. Compositions comprising curons and uses thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"GenBank：JX134045.1 TTV-like mini virus isolate TTMV_LY2", GENBANK, 16 March 2013 (2013-03-16) *
BENDINELLI M等: "Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans", CLINICAL MICROBIOLOGY REVIEWS, vol. 14, no. 1, 31 December 2001 (2001-12-31), pages 98 - 113 *
HAUSEN H Z.等: "TT Viruses: Oncogenic or Tumor-Suppressive Properties?", CURR TOP MICROBIOL IMMUNOL, vol. 331, 31 December 2009 (2009-12-31), pages 109 - 116 *
HOU Z等: "Total Chemical Synthesis, Assembly of Human Torque Teno Virus Genome", VIROLOGICA SINICA, vol. 26, no. 3, 31 December 2011 (2011-12-31), pages 181 - 182 *
JOHANNA GALMÈS等: "Potential implication of new torque teno mini viruses in parapneumonic empyema in children", THE EUROPEAN RESPIRATORY JOURNAL, vol. 42, no. 2, 31 December 2013 (2013-12-31), pages 473 *
NAZISH BOSTAN等: "Current and Future Prospects of Torque Teno Virus", JOURNAL OF VACCINES & VACCINATION, 1 January 2013 (2013-01-01) *
RODNEY P. KINCAID，ET AL: "A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling", PLOS, vol. 9, no. 12, 19 December 2013 (2013-12-19), pages 5, XP055139223, DOI: 10.1371/journal.ppat.1003818 *
VIGNOLINI等: "Investigation on torquetenovirus (TTV) microRNA transcriptome in vivo", VIRUS RESEARCH, vol. 217, 31 December 2016 (2016-12-31), pages 18 *

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Publication number Publication date
IL283781A (en) 2021-07-29
CA3119814A1 (en) 2020-06-18
WO2020123795A3 (en) 2020-08-27
BR112021010925A2 (pt) 2021-08-31
WO2020123795A2 (en) 2020-06-18
EP3894569A2 (en) 2021-10-20
AU2019395418A1 (en) 2021-06-03
US20220073950A1 (en) 2022-03-10
JP2022513459A (ja) 2022-02-08
JP2024099833A (ja) 2024-07-25
KR20210125990A (ko) 2021-10-19
MX2021006945A (es) 2021-08-24

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