KR20210116526A - 증진된 항-신생물 활성 및 면역억제 내성을 갖는 변형된 면역 세포 - Google Patents
증진된 항-신생물 활성 및 면역억제 내성을 갖는 변형된 면역 세포 Download PDFInfo
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- KR20210116526A KR20210116526A KR1020217025456A KR20217025456A KR20210116526A KR 20210116526 A KR20210116526 A KR 20210116526A KR 1020217025456 A KR1020217025456 A KR 1020217025456A KR 20217025456 A KR20217025456 A KR 20217025456A KR 20210116526 A KR20210116526 A KR 20210116526A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N9/14—Hydrolases (3)
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/095—Fusion polypeptide containing a localisation/targetting motif containing a nuclear export signal
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- C12N2510/00—Genetically modified cells
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- C12Y305/04004—Adenosine deaminase (3.5.4.4)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962793277P | 2019-01-16 | 2019-01-16 | |
| US62/793,277 | 2019-01-16 | ||
| US201962839870P | 2019-04-29 | 2019-04-29 | |
| US62/839,870 | 2019-04-29 | ||
| PCT/US2020/013964 WO2020150534A2 (en) | 2019-01-16 | 2020-01-16 | Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210116526A true KR20210116526A (ko) | 2021-09-27 |
Family
ID=71613446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217025456A Ceased KR20210116526A (ko) | 2019-01-16 | 2020-01-16 | 증진된 항-신생물 활성 및 면역억제 내성을 갖는 변형된 면역 세포 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220133790A1 (enExample) |
| EP (1) | EP3911735A4 (enExample) |
| JP (2) | JP2022518463A (enExample) |
| KR (1) | KR20210116526A (enExample) |
| CN (1) | CN114072495A (enExample) |
| AU (2) | AU2020208616A1 (enExample) |
| CA (1) | CA3126699A1 (enExample) |
| SG (1) | SG11202107555XA (enExample) |
| WO (1) | WO2020150534A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102955030B1 (ko) * | 2025-11-04 | 2026-04-23 | 대한민국 | 신규한 가이드 rna 및 이의 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102709603B1 (ko) | 2017-02-28 | 2024-09-27 | 보르 바이오파마 인크. | 계통 특이적 단백질의 억제를 위한 조성물 및 방법 |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| AU2020216484A1 (en) * | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced off-target deamination and methods of using same to modify a nucleobase target sequence |
| US12600971B2 (en) | 2019-02-13 | 2026-04-14 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| US10913941B2 (en) | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| WO2021046243A2 (en) * | 2019-09-03 | 2021-03-11 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| US12594301B2 (en) | 2019-09-27 | 2026-04-07 | Beam Therapeutics Inc. | Compositions and methods for treatment of liquid cancers |
| EP4204564A1 (en) * | 2020-08-28 | 2023-07-05 | Vor Biopharma Inc. | Compositions and methods for cd123 modification |
| EP4211245A1 (en) * | 2020-09-14 | 2023-07-19 | Vor Biopharma Inc. | Compositions and methods for cd5 modification |
| WO2022061115A1 (en) * | 2020-09-18 | 2022-03-24 | Vor Biopharma Inc. | Compositions and methods for cd7 modification |
| KR20230074515A (ko) * | 2020-09-23 | 2023-05-30 | 크리스퍼 테라퓨틱스 아게 | 개선된 기능성 및 지속성을 갖는 붕괴된 레그나제-1 및/또는 tgfbrii를 지니는 유전자 조작된 t 세포 |
| AU2021347359A1 (en) * | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| WO2022072643A1 (en) * | 2020-09-30 | 2022-04-07 | Vor Biopharma Inc. | Compositions and methods for cd30 gene modification |
| CN116801890A (zh) * | 2020-11-04 | 2023-09-22 | 小利兰·斯坦福大学董事会 | 用于增强治疗性免疫细胞功效的方法和组合物 |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| EP4255453A4 (en) * | 2020-12-03 | 2025-03-26 | Nkarta, Inc. | Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy |
| EP4259792A1 (en) * | 2020-12-11 | 2023-10-18 | Intellia Therapeutics, Inc. | Polynucleotides, compositions, and methods for genome editing involving deamination |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| MX2023008809A (es) | 2021-01-29 | 2023-08-04 | Allogene Therapeutics Inc | ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. |
| WO2022215978A1 (ko) * | 2021-04-05 | 2022-10-13 | 주식회사 셀렌진 | Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도 |
| CN113179160B (zh) * | 2021-04-15 | 2022-03-18 | 中国电子科技集团公司第三十研究所 | 一种适用于qkd中私钥放大的最优输入码长处理方法及单元 |
| CA3217459A1 (en) * | 2021-05-06 | 2022-11-10 | Spyro Mousses | Compositions for inhibiting growth of targeted cells |
| WO2022241029A1 (en) * | 2021-05-11 | 2022-11-17 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| EP4388105A4 (en) * | 2021-08-16 | 2026-02-11 | Beam Therapeutics Inc | Persistent Allogeneic Modified Immune Cells and Their Methods of Use |
| CN119452085A (zh) | 2021-08-27 | 2025-02-14 | 宏基因组学公司 | 具有ruvc结构域的酶 |
| US20250134998A1 (en) * | 2021-08-30 | 2025-05-01 | The Board Of Trustees Of The Leland Stanford Junior University | T cells with cell-surface expression of adenosine deaminase and uses thereof |
| MX2024003887A (es) | 2021-10-14 | 2024-07-09 | Arsenal Biosciences Inc | Células inmunitarias que tienen arnch coespresados y sistemas de compuerta lógica. |
| CN113980896B (zh) * | 2021-10-27 | 2023-10-20 | 中国人民解放军军事科学院军事医学研究院 | Irf1在调控间充质干细胞免疫调节作用及产品上的应用 |
| WO2023081200A2 (en) * | 2021-11-03 | 2023-05-11 | Intellia Therapeutics, Inc. | Cd38 compositions and methods for immunotherapy |
| EP4430195A4 (en) * | 2021-11-12 | 2025-09-24 | Georgia Tech Res Inst | ADENOSINE DEAMINASE 1 COMPOSITIONS AND METHODS OF USE THEREOF |
| KR20240110603A (ko) | 2021-11-24 | 2024-07-15 | 메타지노미, 인크. | 엔도뉴클레아제 시스템 |
| CA3242360A1 (en) * | 2021-12-10 | 2023-06-15 | Beam Therapeutics Inc. | Modified immune cells and methods of using the same |
| WO2023114777A2 (en) * | 2021-12-14 | 2023-06-22 | The Trustees Of The University Of Pennsylvania | Cd5 modified cells comprising chimeric antigen receptors (cars) for treatment of solid tumors |
| CN114774364B (zh) * | 2022-04-26 | 2024-04-26 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其制备方法和应用 |
| EP4532697A2 (en) * | 2022-06-03 | 2025-04-09 | Beam Therapeutics Inc. | Modified regulatory t cells and methods of using the same |
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| KR20240035722A (ko) * | 2022-09-08 | 2024-03-18 | 주식회사 에이조스바이오 | 세포 내 형질주입을 위한 신규한 폴리펩타이드 조성물 |
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| TW202442689A (zh) | 2023-03-03 | 2024-11-01 | 美商亞森諾生物科學公司 | 靶向psma及ca9之系統 |
| WO2024186841A2 (en) * | 2023-03-06 | 2024-09-12 | La Jolla Institute For Immunology | Nfkbid cells and methods for immunotherapy |
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| EP4694917A1 (en) * | 2023-04-12 | 2026-02-18 | Beam Therapeutics Inc. | Modified immune effector cells with improved efficacy |
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| WO2024249346A1 (en) * | 2023-05-26 | 2024-12-05 | Editas Medicine, Inc. | Crispr-related methods and compositions targeting cd70 expression |
| CN116590237B (zh) * | 2023-05-29 | 2023-10-31 | 上海贝斯昂科生物科技有限公司 | 一种遗传修饰的自然杀伤细胞及其制备和用途 |
| WO2025111533A1 (en) * | 2023-11-22 | 2025-05-30 | The General Hospital Corporation | Car-t cells comprising a cdkn1b gene knockout and methods of use thereof |
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| IT202400011104A1 (it) * | 2024-05-16 | 2025-11-16 | Fondazione St Italiano Tecnologia | Progettazione di mirna sintetici per ristabilire il corretto dosaggio genico dei geni associati all'esaurimento dei linfociti t |
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| KR102546296B1 (ko) * | 2014-10-31 | 2023-06-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도 |
| AU2016279062A1 (en) * | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
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| US20170020922A1 (en) * | 2015-07-16 | 2017-01-26 | Batu Biologics Inc. | Gene editing for immunological destruction of neoplasia |
| WO2017070632A2 (en) * | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2017093969A1 (en) * | 2015-12-04 | 2017-06-08 | Novartis Ag | Compositions and methods for immunooncology |
| SG10202109385QA (en) * | 2016-07-05 | 2021-10-28 | Univ Johns Hopkins | Crispr/cas9-based compositions and methods for treating retinal degenerations |
| CN108753823B (zh) * | 2018-06-20 | 2022-09-23 | 李广磊 | 利用碱基编辑技术实现基因敲除的方法及其应用 |
| CN108949825A (zh) * | 2018-07-30 | 2018-12-07 | 苏州茂行生物科技有限公司 | 一种靶向her2的car-t细胞的制备方法及应用 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102955030B1 (ko) * | 2025-11-04 | 2026-04-23 | 대한민국 | 신규한 가이드 rna 및 이의 용도 |
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| EP3911735A2 (en) | 2021-11-24 |
| US20220133790A1 (en) | 2022-05-05 |
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| CA3126699A1 (en) | 2020-07-23 |
| EP3911735A4 (en) | 2023-07-12 |
| SG11202107555XA (en) | 2021-08-30 |
| CN114072495A (zh) | 2022-02-18 |
| WO2020150534A3 (en) | 2020-10-01 |
| AU2026204466A1 (en) | 2026-07-09 |
| AU2020208616A1 (en) | 2021-08-12 |
| WO2020150534A2 (en) | 2020-07-23 |
| JP2024174899A (ja) | 2024-12-17 |
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