KR20210102247A - Crispr 수퍼-리프레서에 의한 생체내 합성 면역조절 - Google Patents

Crispr 수퍼-리프레서에 의한 생체내 합성 면역조절 Download PDF

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KR20210102247A
KR20210102247A KR1020217017529A KR20217017529A KR20210102247A KR 20210102247 A KR20210102247 A KR 20210102247A KR 1020217017529 A KR1020217017529 A KR 1020217017529A KR 20217017529 A KR20217017529 A KR 20217017529A KR 20210102247 A KR20210102247 A KR 20210102247A
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myd88
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synthetic
crispr
grna
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사미라 키아니
모 레자 에브라힘카니
파르자네 모그하담
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아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티
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KR1020217017529A 2018-11-08 2019-11-07 Crispr 수퍼-리프레서에 의한 생체내 합성 면역조절 Ceased KR20210102247A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862757679P 2018-11-08 2018-11-08
US62/757,679 2018-11-08
US201962899584P 2019-09-12 2019-09-12
US62/899,584 2019-09-12
PCT/US2019/060285 WO2020097344A1 (en) 2018-11-08 2019-11-07 Synthetic immunomodulation with a crispr super-repressor in vivo

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KR20210102247A true KR20210102247A (ko) 2021-08-19

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KR1020217017529A Ceased KR20210102247A (ko) 2018-11-08 2019-11-07 Crispr 수퍼-리프레서에 의한 생체내 합성 면역조절

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US (2) US11884925B2 (https=)
EP (1) EP3877398A4 (https=)
JP (1) JP2022512974A (https=)
KR (1) KR20210102247A (https=)
CN (1) CN113330023A (https=)
AU (1) AU2019375914A1 (https=)
CA (1) CA3119302A1 (https=)
IL (1) IL283022A (https=)
SG (1) SG11202104802RA (https=)
WO (1) WO2020097344A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11773407B2 (en) 2017-06-26 2023-10-03 Arizona Board Of Regents On Behalf Of Arizona State University CRISPR logic circuits for safer and controllable gene therapies
US20200123567A1 (en) 2017-06-26 2020-04-23 Samira Kiani A universal platform to enhance crispr-based gene editing for in vivo therapies
WO2023288306A2 (en) * 2021-07-16 2023-01-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Targeting myd88 gene in vitro and in vivo
EP4479538A4 (en) * 2022-02-17 2026-01-28 Syntax Bio Inc CELL PROGRAMMING SYSTEMS AND ASSOCIATED PROCESSES
EP4711456A1 (en) * 2024-09-11 2026-03-18 GenCC GmbH & Co. KG Method for the manufacture of individualized crispr/cas complexes and individualized crispr/cas complexes

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
EP0931158A1 (en) 1996-09-06 1999-07-28 The Trustees Of The University Of Pennsylvania An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
US20030148986A1 (en) * 2001-12-17 2003-08-07 Cedars-Sinai Medical Center Methods for treating vascular disease by inhibiting myeloid differentiation factor 88
CN102166214B (zh) 2011-03-02 2012-12-12 华中科技大学同济医学院附属同济医院 氨基噻唑类MyD88特异性抑制剂在医学上的用途
US9228207B2 (en) * 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
JP6793547B2 (ja) * 2013-12-12 2020-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
CN106456801A (zh) * 2014-02-07 2017-02-22 Sbi生物技术有限公司 用于治疗肿瘤的抑制性寡核苷酸
WO2016049258A2 (en) * 2014-09-25 2016-03-31 The Broad Institute Inc. Functional screening with optimized functional crispr-cas systems
WO2016094872A1 (en) * 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
TWI906646B (zh) * 2015-06-18 2025-12-01 美商博得學院股份有限公司 降低脫靶效應的ｃｒｉｓｐｒ酶突變
US9790490B2 (en) * 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
NZ735250A (en) 2015-07-08 2020-08-28 Research & Business Found Sungkyunkwan Univ Pyrrolidine carboxamido derivatives and methods for preparing and using the same
WO2017068077A1 (en) 2015-10-20 2017-04-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods and products for genetic engineering
US11439692B2 (en) * 2017-05-17 2022-09-13 Modalis Therapeutics Corporation Method of treating diseases associated with MYD88 pathways using CRISPR-GNDM system
US11773407B2 (en) * 2017-06-26 2023-10-03 Arizona Board Of Regents On Behalf Of Arizona State University CRISPR logic circuits for safer and controllable gene therapies

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SG11202104802RA (en) 2021-06-29
EP3877398A1 (en) 2021-09-15
IL283022A (en) 2021-06-30
CN113330023A (zh) 2021-08-31
EP3877398A4 (en) 2022-08-17
US11884925B2 (en) 2024-01-30
WO2020097344A1 (en) 2020-05-14
US20210380990A1 (en) 2021-12-09
JP2022512974A (ja) 2022-02-07
CA3119302A1 (en) 2020-05-14
AU2019375914A1 (en) 2021-06-03
US20240117364A1 (en) 2024-04-11

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