KR20210090650A - 알파바이러스 신생항원 벡터 및 인터페론 억제제 - Google Patents

알파바이러스 신생항원 벡터 및 인터페론 억제제 Download PDF

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KR20210090650A
KR20210090650A KR1020217016771A KR20217016771A KR20210090650A KR 20210090650 A KR20210090650 A KR 20210090650A KR 1020217016771 A KR1020217016771 A KR 1020217016771A KR 20217016771 A KR20217016771 A KR 20217016771A KR 20210090650 A KR20210090650 A KR 20210090650A
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nucleic acid
epitope
acid sequence
encoding nucleic
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카린 주스
에이미 레이첼 라파포트
레오니드 기틀린
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그릿스톤 바이오, 인코포레이티드
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KR1020217016771A 2018-11-07 2019-11-07 알파바이러스 신생항원 벡터 및 인터페론 억제제 Ceased KR20210090650A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862756980P 2018-11-07 2018-11-07
US62/756,980 2018-11-07
PCT/US2019/060355 WO2020097393A1 (en) 2018-11-07 2019-11-07 Alphavirus neoantigen vectors and interferon inhibitors

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KR20210090650A true KR20210090650A (ko) 2021-07-20

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US (1) US20220125919A1 (https=)
EP (1) EP3877531A4 (https=)
JP (1) JP2022512912A (https=)
KR (1) KR20210090650A (https=)
CN (1) CN112912507A (https=)
AU (1) AU2019374874A1 (https=)
CA (1) CA3119752A1 (https=)
IL (1) IL282793A (https=)
WO (1) WO2020097393A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3634449A4 (en) 2017-05-08 2021-03-17 Gritstone Oncology, Inc. ALPHAVIRUS NEOANTIGEN VECTORS
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
US20230031287A1 (en) * 2019-12-13 2023-02-02 Northwestern University Method and composition for enhancing the immune response
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022011429A1 (en) * 2020-07-17 2022-01-20 The University Of Western Australia Methods to increase response to immune checkpoint modulation
CN111991569B (zh) * 2020-07-22 2021-09-28 华中科技大学 一种双靶向乳腺癌细胞及其淋巴结转移灶的纳米颗粒、制备方法及应用
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒
GB202020063D0 (en) * 2020-12-17 2021-02-03 Imperial College Innovations Ltd RNA construct
GB202020061D0 (en) * 2020-12-17 2021-02-03 Imp College Innovations Ltd RNA construct
EP4583861A1 (en) * 2022-09-09 2025-07-16 Spark Therapeutics, Inc. Enhancing non-viral dna delivery and expression
WO2025090933A1 (en) * 2023-10-26 2025-05-01 The Trustees Of The University Of Pennsylvania Methods and compositions comprising a type i interferon (ifn1) inhibitor
CN117457069A (zh) * 2023-10-30 2024-01-26 南方医科大学南方医院 一种基于m7G相关基因突变对肝癌进行分型的方法和生存预测模型构建
WO2026013528A1 (en) * 2024-07-08 2026-01-15 Ramot At Tel-Aviv University Ltd. A method and composition for treating cancer with an anti-ly6e antibody to reprogram cd8+ t cells for cancer immunotherapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451592B1 (en) * 1996-04-05 2002-09-17 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
AU2003222068A1 (en) * 2002-03-25 2003-10-13 University Of North Carolina At Chapel Hill Improved methods for achieving expression from alphavirus vectors
EP2848692B1 (en) * 2004-05-21 2017-08-16 Novartis Vaccines and Diagnostics, Inc. Alphavirus vectors for influenza virus vaccines
US20110117124A1 (en) * 2007-08-31 2011-05-19 Sadoff Jerald C Enhancement of transgene expression from viral-based vaccine vectors by expression of suppressors of the type i interferon response
JP2020500552A (ja) * 2016-11-23 2020-01-16 グリットストーン オンコロジー インコーポレイテッド 新生抗原のウイルスによる送達方法
CA3060569A1 (en) * 2017-04-19 2018-10-25 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
JP2021524247A (ja) * 2018-05-23 2021-09-13 グリットストーン バイオ インコーポレイテッド 免疫チェックポイント阻害剤の共発現ベクター

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