CA3119752A1 - Alphavirus neoantigen vectors and interferon inhibitors - Google Patents

Alphavirus neoantigen vectors and interferon inhibitors Download PDF

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Publication number
CA3119752A1
CA3119752A1 CA3119752A CA3119752A CA3119752A1 CA 3119752 A1 CA3119752 A1 CA 3119752A1 CA 3119752 A CA3119752 A CA 3119752A CA 3119752 A CA3119752 A CA 3119752A CA 3119752 A1 CA3119752 A1 CA 3119752A1
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Canada
Prior art keywords
sequence
nucleic acid
acid sequence
encoding nucleic
epitope
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Pending
Application number
CA3119752A
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English (en)
French (fr)
Inventor
Karin Jooss
Amy Rachel Rappaport
Leonid Gitlin
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Gritstone Bio Inc
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Gritstone Oncology Inc
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Filing date
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Application filed by Gritstone Oncology Inc filed Critical Gritstone Oncology Inc
Publication of CA3119752A1 publication Critical patent/CA3119752A1/en
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4201—Neoantigens
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biotechnology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
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  • Biomedical Technology (AREA)
  • Biophysics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
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CA3119752A 2018-11-07 2019-11-07 Alphavirus neoantigen vectors and interferon inhibitors Pending CA3119752A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862756980P 2018-11-07 2018-11-07
US62/756,980 2018-11-07
PCT/US2019/060355 WO2020097393A1 (en) 2018-11-07 2019-11-07 Alphavirus neoantigen vectors and interferon inhibitors

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CA3119752A1 true CA3119752A1 (en) 2020-05-14

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CA3119752A Pending CA3119752A1 (en) 2018-11-07 2019-11-07 Alphavirus neoantigen vectors and interferon inhibitors

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US (1) US20220125919A1 (https=)
EP (1) EP3877531A4 (https=)
JP (1) JP2022512912A (https=)
KR (1) KR20210090650A (https=)
CN (1) CN112912507A (https=)
AU (1) AU2019374874A1 (https=)
CA (1) CA3119752A1 (https=)
IL (1) IL282793A (https=)
WO (1) WO2020097393A1 (https=)

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EP3634449A4 (en) 2017-05-08 2021-03-17 Gritstone Oncology, Inc. ALPHAVIRUS NEOANTIGEN VECTORS
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
US20230031287A1 (en) * 2019-12-13 2023-02-02 Northwestern University Method and composition for enhancing the immune response
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022011429A1 (en) * 2020-07-17 2022-01-20 The University Of Western Australia Methods to increase response to immune checkpoint modulation
CN111991569B (zh) * 2020-07-22 2021-09-28 华中科技大学 一种双靶向乳腺癌细胞及其淋巴结转移灶的纳米颗粒、制备方法及应用
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒
GB202020063D0 (en) * 2020-12-17 2021-02-03 Imperial College Innovations Ltd RNA construct
GB202020061D0 (en) * 2020-12-17 2021-02-03 Imp College Innovations Ltd RNA construct
EP4583861A1 (en) * 2022-09-09 2025-07-16 Spark Therapeutics, Inc. Enhancing non-viral dna delivery and expression
WO2025090933A1 (en) * 2023-10-26 2025-05-01 The Trustees Of The University Of Pennsylvania Methods and compositions comprising a type i interferon (ifn1) inhibitor
CN117457069A (zh) * 2023-10-30 2024-01-26 南方医科大学南方医院 一种基于m7G相关基因突变对肝癌进行分型的方法和生存预测模型构建
WO2026013528A1 (en) * 2024-07-08 2026-01-15 Ramot At Tel-Aviv University Ltd. A method and composition for treating cancer with an anti-ly6e antibody to reprogram cd8+ t cells for cancer immunotherapy

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