KR20210065110A - 알콕시메틸렌-벤조일아세토니트릴의 제조를 위한 합성 방법 - Google Patents

알콕시메틸렌-벤조일아세토니트릴의 제조를 위한 합성 방법 Download PDF

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Publication number
KR20210065110A
KR20210065110A KR1020217008900A KR20217008900A KR20210065110A KR 20210065110 A KR20210065110 A KR 20210065110A KR 1020217008900 A KR1020217008900 A KR 1020217008900A KR 20217008900 A KR20217008900 A KR 20217008900A KR 20210065110 A KR20210065110 A KR 20210065110A
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KR
South Korea
Prior art keywords
compound
orthoformate
formula
reaction
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020217008900A
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English (en)
Korean (ko)
Inventor
마르크 마이센바흐
벤야민 마르틴
니크 요하네스 론데
Original Assignee
메레오 바이오파마 1 리미티드
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Application filed by 메레오 바이오파마 1 리미티드 filed Critical 메레오 바이오파마 1 리미티드
Publication of KR20210065110A publication Critical patent/KR20210065110A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/009—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping in combination with chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217008900A 2018-09-26 2019-09-26 알콕시메틸렌-벤조일아세토니트릴의 제조를 위한 합성 방법 Ceased KR20210065110A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1815699.2A GB201815699D0 (en) 2018-09-26 2018-09-26 Synthetic method
GB1815699.2 2018-09-26
PCT/GB2019/052720 WO2020065325A1 (en) 2018-09-26 2019-09-26 Synthetic methodfor the preparation of an alkoxymethylene-benzoylacetonitrile

Publications (1)

Publication Number Publication Date
KR20210065110A true KR20210065110A (ko) 2021-06-03

Family

ID=64024259

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217008900A Ceased KR20210065110A (ko) 2018-09-26 2019-09-26 알콕시메틸렌-벤조일아세토니트릴의 제조를 위한 합성 방법

Country Status (12)

Country Link
US (1) US20220033352A1 (https=)
EP (1) EP3856712B1 (https=)
JP (1) JP2022502413A (https=)
KR (1) KR20210065110A (https=)
CN (1) CN112805269A (https=)
AU (1) AU2019348974A1 (https=)
CA (1) CA3113000A1 (https=)
DK (1) DK3856712T3 (https=)
ES (1) ES2933687T3 (https=)
GB (1) GB201815699D0 (https=)
IL (1) IL281635A (https=)
WO (1) WO2020065325A1 (https=)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1809386A1 (de) * 1968-11-16 1970-06-11 Bayer Ag Verfahren zur Herstellung von 1,5-disubstituierten 4-Cyanopyrazolen
JPS62174055A (ja) * 1985-10-01 1987-07-30 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
CA2329065A1 (en) * 1998-05-05 1999-11-11 Francisco Xavier Talamas Pyrazole derivatives as p-38 map kinase inhibitors
KR101120857B1 (ko) 2003-06-26 2012-04-12 노파르티스 아게 5원의 헤테로사이클-기재 ｐ38 키나제 억제제

Also Published As

Publication number Publication date
WO2020065325A1 (en) 2020-04-02
CN112805269A (zh) 2021-05-14
DK3856712T3 (da) 2022-12-12
CA3113000A1 (en) 2020-04-02
IL281635A (en) 2021-05-31
AU2019348974A1 (en) 2021-04-22
EP3856712B1 (en) 2022-10-26
ES2933687T3 (es) 2023-02-13
JP2022502413A (ja) 2022-01-11
GB201815699D0 (en) 2018-11-07
US20220033352A1 (en) 2022-02-03
EP3856712A1 (en) 2021-08-04

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