KR20210039069A - Composition for teeth whitening containing enteromorpha extracts - Google Patents

Abstract

The present invention relates to a composition for teeth whitening containing a salted laver extract as an active component. More specifically, when using a seaweed extract containing a salted laver extract, it is possible to provide a composition for teeth whitening which does not contain hydrogen peroxide or titanium dioxide and exhibits an excellent tooth whitening effect and excellent human stability at the same time.

Description

Composition for teeth whitening containing green laver extract as an active ingredient {COMPOSITION FOR TEETH WHITENING CONTAINING ENTEROMORPHA EXTRACTS}

The present invention relates to a composition for whitening teeth comprising a green seaweed extract as an active ingredient. In more detail, using the seaweed extract containing green seaweed extract, it does not contain chemicals such as hydrogen peroxide used for whitening teeth, and exhibits excellent teeth whitening effect, and at the same time, it is used in a composition for teeth whitening having excellent human stability. About.

The teeth break down food into small pieces to facilitate digestion in the gastrointestinal tract (mastication function), a vocalization assist function (pronunciation function) that helps correct pronunciation, and a cosmetic function that allows you to feel beauty for yourself or others. Have, are the main structural organs of the human body. The cosmetic function of teeth is influenced by the tone, appearance, and arrangement of the teeth.In particular, the appearance and arrangement of teeth is closely related to the smooth mastication and pronunciation functions, so it is recommended to correct them correctly through various treatments and procedures. Are doing. However, since the effect of tooth tone has no adverse effect other than the cosmetic aspect, the importance and urgency of tooth whitening have been relatively devalued until recently. However, as society develops and the standard of living of the people increases, the importance of aesthetic treatment has recently emerged, compared to the previously performed function-oriented dental treatment. In particular, there is an increasing interest and demand for tooth whitening, which can obtain satisfactory results by a person to be treated by a relatively easy method without removal of teeth or mechanical movement (correction).

In accordance with this trend, efforts to research and develop more effective methods or active ingredients for whitening teeth at home and abroad are being conducted in various ways.

Discoloration of teeth can also be a cause of stress for many people to be unable to laugh brightly. Tooth discoloration can be divided into exogenous discoloration and endogenous discoloration. Exogenous causes may be caused by coloring by depositing food residues on the tooth surface or dentin of teeth such as nicotine, coffee, black tea, etc., and by dyeing pigments in tartar or soft deposits on the tooth surface. It can also be caused by pigmented bacteria or gingival bleeding, excessive intake of fluoride and medication. Endogenous causes include discoloration due to damage to the tooth nerve, discoloration due to silver amalgam, a dental prosthesis material, and discoloration due to taking tetracycline antibiotics.

Among these causes, exogenous discoloration can be easily removed by brushing, but endogenous discoloration cannot be removed with toothpaste or brushing. Therefore, there is a limit to tooth whitening using toothpaste, and it is difficult to completely remove such endogenous discolored teeth. As a method for treating such discoloration of teeth, a physical treatment method and a treatment method using a medicinal agent have been developed.

As the representative dental discoloration treatment method, a temporary method of putting a jacket crown on discolored teeth and a method of treating stains through scaling through dental hygienists have been developed, but treatment costs are high. Problems such as the hassle of visiting a dental hospital have been pointed out. As another method, a bristle toothbrush or a method of using a strong abrasive has been developed.

As the representative abrasives, insoluble sodium metaphosphate (Insoluble Natrium Metaphosphate), anhydrous calcium monohydrogen phosphate, and the like have been developed to remove them by a physical method. However, when the tooth is cleaned with a formulation containing these substances, the enamel or the cervical portion of the tooth surface is worn or damaged, and when external stimuli such as mechanical or chemical stimulation or temperature are applied to the exposed dentin, it may become cold or cold. Even more, it is likely to become a sensitive tooth causing pain, and it has been pointed out that it is difficult to remove stains effectively.

For this reason, teeth whitening using hydrogen peroxide and titanium dioxide was developed. Geotinde using a chemical reaction in order to remove colored contaminants to the tooth surface and development of a lot of teeth whitening products using the Recent hydrogen peroxide, but broken alkali metal, heavy metal and dioxide needs are well decomposed into water and oxygen by the inorganic material, such as (MnO ₂₎ It has a big problem that the stability of hydrogen peroxide is poor.

Therefore, the peroxides are not compatible with toothpaste raw materials. In particular, when used with sodium hydrogen carbonate, it exhibits a high whitening effect, but it is difficult to store the product using it for a long time due to the rapid decomposition of peroxide, gas generation, and phase separation.When stored at room temperature, the stability of peroxide in toothpaste is poor, making it difficult to commercialize it. There is this.

In addition, titanium dioxide serves as a photocatalyst for hydrogen peroxide, so that teeth whitening effect is excellent, but there is a difficulty in maintaining the stability of hydrogen peroxide for a long time when it belongs to a tooth whitening composition. In addition, the method of using only the tooth whitening agent composition has a disadvantage that it is difficult to obtain an expected level of whitening effect by being washed down from the tooth surface by saliva or the like during application.

Accordingly, there is an urgent need to develop a composition that does not contain chemical substances such as hydrogen peroxide and titanium dioxide and has an excellent tooth whitening effect.

KR 10-0871627 B1

It is an object of the present invention to provide a composition for whitening teeth comprising a green onion extract as an active ingredient.

Another object of the present invention is to provide a composition for whitening teeth that exhibits excellent teeth whitening effect and has excellent human stability while using natural extracts.

In order to achieve the above object, the composition for whitening teeth according to an embodiment of the present invention includes a green seaweed extract.

The composition further comprises an extract of seaweed (Undaria pinnatifida).

The composition further includes xylitol, peppermint essential oil, vegetable glycerin, an abrasive and a thickener.

The extract is extracted using an extraction solvent selected from the group consisting of water, C ₁ to C _{6 lower alcohols and mixtures thereof.}

The toothpaste for whitening according to another embodiment of the present invention is prepared by using a tooth whitening composition comprising the green seaweed extract as an active ingredient.

The gargle solution according to another embodiment of the present invention is prepared by using a tooth whitening composition comprising the green seaweed extract as an active ingredient.

Oral spray according to another embodiment of the present invention is prepared using a tooth whitening composition comprising the green seaweed extract as an active ingredient.

Hereinafter, the present invention will be described in more detail.

As used herein, the term'extract' has the meaning commonly used as a crude extract in the art as described above, but broadly includes a fraction obtained by additionally fractionating the extract. That is, the plant extract includes not only those obtained by using the above-described extraction solvent, but also those obtained by additionally applying a purification process thereto. For example, fractions obtained by passing the extract through an outer filtration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through various purification methods are also included in the plant extract of the present invention.

The extract used in the present invention may be prepared in a powder state by an additional process such as distillation under reduced pressure and freeze drying or spray drying.

In order to achieve the above object, the composition for whitening teeth according to an embodiment of the present invention includes a green seaweed extract.

Seaweed is a low-calorie food containing a large amount of protein and dietary fiber useful for health, but the fat content is less than 1%, and omega-3 fatty acids, which are effective in preventing cardiovascular diseases, contain large amounts of eicosapentaenoic acid (EPA). It is a very excellent food resource containing. In addition, laver contains a large amount of pigments such as chlorophyll, carotenoids, and picobilin, which provides color to food, and contains natural antioxidants such as polyphenol compounds, which are reported to exhibit radical scavenging effects, delaying aging, and inhibiting carcinogenesis. .

However, as shown in most food resources, there are differences in the content of nutrients and functional ingredients as well as physiological activity according to the varieties and types of kimdo. In particular, green seaweed is rich in calcium, which is good for teeth, atopy or hypersensitivity dermatitis. It is effective in calming down.

Piraekim literally is made of green laver (Enteromorpha), and green laver is a type of seaweed, meaning a plant in the genus Enteromorpha sp. The genus Green is a plant belonging to the Algaeaceae family, E. linza, E. intestinalis, E. compressa, E. prolifera, or E. clathrata. ), etc. may be included, and preferably may be leaf green. Most of the plants in the genus Green are branched or monotonous with a cylindrical frond, and depending on the type, the upper part may spread to the frond, and taxonomically, one type of a hollow cylindrical shape is included therein. They mainly grow well in the upper intertidal zone on the seashore, especially where fresh water flows in, and often form large communities in quiet tidal pools. It breeds mainly from late autumn to early summer, and is used for food in Korea and Japan.

The green algae (Enteromorpha linza) is a green algae belonging to the sea end of the green algae plant Galparaeaceae. The frond is an elongated and flat frond, monotonous, and the lower part sometimes protrudes a few branches. It is widely distributed all over the world, and in the case of Korea, it is distributed all over the coast, and mainly inhabits rocks in the upper intertidal zone or woodwork in bays. In addition, green leaf is mainly used for food, and it is also used as kimchi or soup.

The tooth whitening composition further includes an extract of seaweed (Undaria pinnatifida).

Seaweed (Undaria pinnatifida) is a brown algae of the seaweed family that inhabits seas and is similar to a plant, but in classification, it belongs to a protozoan plant, not a plant. It is edible because it contains minerals, vitamins and fiber components, viscous polysaccharides, and iodine. It is a food mainly used in Northeast Asia such as China, Japan, and Korea, and Korean records show that it was eaten even in the 12th century during the Goryeo Dynasty, and Chinese records indicate that Koreans were eating it in the 8th century. Was edible. Dried seaweed contains 12.7% protein, 52% sugar, fat, 1.1%, Ca 1,300mg%, vitamin A 470IU, B1 0.11mg%, B2 0.14mg%, C15mg%, nicotinic acid 10mg%. Silver alginic acid, which is secreted from the mucous glands, is contained in more leaves or stems than in roots. Polysaccharides in seaweed are not digested or absorbed by the human body and are excreted as they are, so they are not used as a source of calories. On the other hand, alginates are effective in removing harmful metals due to their strong metal absorption, and fibers containing 5-15% of them work together with polysaccharides to intestinal tracts. It is a good source of nutrients as it contains iron, zinc, iodine, potassium, and calcium as trace minerals. Therefore, seaweed is a food ingredient that exhibits a source of vitamins and minerals, intestinal action, alkaline foods, removal of harmful metals, and anti-cholesterol effects in food nutrition.

When the green seaweed extract and seaweed extract are used as a tooth whitening composition, the tooth whitening effect is excellent by the active ingredients contained in the green seaweed extract and seaweed extract. More specifically, it can exhibit an excellent whitening effect of endogenously discolored teeth by vitamins and amino acids contained in the green seaweed extract and seaweed extract.

The composition further includes xylitol, peppermint essential oil, vegetable glycerin, an abrasive and a thickener.

The xylitol is a sugar alcohol-based natural sweetener used in chewing gum, confectionery, pharmaceuticals, oral hygiene, and the like. Xylitol is effective in preventing tooth decay because it has a pentose structure. Tooth decay is the phenomenon that lactic acid, which is released by eating glucose or fructose in food by the caries mutans or sorbinus bacteria, corrodes the surface of the teeth.The caries bacteria easily decompose hexasaccharides, but xylitol, which is a pentasaccharide, does not easily decompose. can not do it. As a result, the acid, which is the cause of tooth decay, does not occur, and the caries bacteria that have not ingested nutrients eventually fall off the tooth surface. In addition, xylitol is also used as an additive to prevent tooth decay because it is suitable for preventing tooth decay, such as promoting saliva secretion, as it has a refreshing effect to cool the mouth.

The vegetable glycerin is also called 　glycerol and has a sweet taste in the form of a transparent syrup. Glycerin prevents moisture evaporation and helps supply moisture. In addition, glycerin is harmless to the human body, has an excellent moisturizing effect, and has strong hygroscopic power. Vegetable glycerin is a natural product made from palm oil and palm oil as raw materials. It is a component that is easily soluble in water. It has the effect of suppressing dermatitis, especially when used in the oral cavity, and can prevent dry mouth.

In the peppermint essential oil, peppermint (Mentha piperita) contains menthol and menthone as constituents, is effective in treating itching or inflammation, and is known to be effective in antiseptic, anticonvulsant and expectorant. .

In particular, peppermint's anticonvulsant action is based on its action on the nervous system, and the fresh and spicy menthol flavor awakens the nerves and brain to improve concentration. It has a local anesthetic effect on muscle pain, back pain, bruises, joint pain, and toothache. In addition, it is one of the most effective oils for the digestive system and is effective for indigestion, motion sickness, stomach pain, diarrhea and flatulence. It constricts blood vessels and accelerates the flow of blood vessels to the spleen, promoting blood cell regeneration activity. In addition, it constricts and relaxes lymph and fascia, strengthens the function of smooth toxin removal, and helps relieve headaches and migraine headaches.

The thickener is for maintaining a constant viscosity, and may include a thickener of a natural component. The thickener is selected from the group consisting of xanthan gum, natural cellulose, high cell, methylcellulose, carbomer, carbopol pregel, and gelatin, and more specifically xanthan gum, but is not limited to the above examples.

The abrasive may be selected from the group consisting of baking soda, calcium carbonate, and mixtures thereof, and precipitated calcium carbonate may be used as an example of the calcium carbonate. Such baking soda; Calcium carbonate; Alternatively, precipitated calcium carbonate can remove plaque from the tooth surface.

Preferably, the composition for whitening teeth of the present invention further comprises a dulce extract, a pinworm extract, and a stone agar extract in addition to the green seaweed extract and seaweed extract.

Polysaccharides contained in seaweed are attracting attention as various physiologically active substances due to molecular structural characteristics as well as various physiological functions.

The dulce (Palmaria palmata) grows in the northern coasts of the Atlantic and Pacific Oceans as a red algae and limbs. Dulce is rich in protein, calcium, magnesium and iron, and has long been edible by people in coastal Europe. In particular, dulce is mainly used in soups and salads because of its soft texture and strong scent.

Gracilaria verrucosa (Hudson) Paperfuss is an algae of the red algae family, and is called Kosirak in Jangheung, Wando, Haenam, and Jindo. Stems with a diameter of 1-3㎜ usually grow about 20cm and grow up to 2-3m. The body is gathered from small tray-shaped roots and has a cylindrical shape. It is densely divided into pinnates and branches are skewed to one side. Branches protruding from the body are wire-shaped with a diameter of 1 to 2 mm, and are blackish purple or dark brown. It lives on rocks and seashells in the intertidal zone. Especially, it breeds on pebbles or piles of shallow beaches where river water flows into the sea, and grows on reefs in the open sea. In particular, they form a large colony in the inner bay, and there are sometimes very large individuals in places where fresh water flows. Trunks and branches that have fallen from their habitat can wander anywhere in the sea, and the growth between them is fast, so they are larger than ordinary plants that live together. It is edible or mixed with agar to make agar. The collected items are dried and stored. Blanching in hot water destroys phycopyrin, a pigment that has a reddish color, and only chlorophyll, a pigment that has a green color, remains and turns green. The season is from early spring to late autumn. It is said to have a low content of fat and carbohydrates, a large amount of calcium and dietary fiber, and is said to be effective in releasing heavy metals from the body.

Chondracanthustenellus, also known as a lagoon, is mainly distributed in the western coast of the North Pacific Ocean, and is a seaweed in the family of stone agar. It lives on the rock in the lower part of the intertidal zone, is 5~12cm in height, and the cylindrical branches are misaligned or faced several times. Branches are pointed. The central part of the branch is 1~2mm wide. The color is purple or reddish purple, and it fluoresces in water, and it is a little hard cartilage. It is commonly used as a mixed raw material in the manufacture of agar. It is widely distributed in all coasts of Korea and Japan.

The green laver extract and seaweed extract are mixed with a dulce extract, a pinworm extract, and a stone agar extract to provide a tooth whitening composition, and according to the synergistic effect of the mixed use, superior tooth whitening effect compared to the case of using only the green laver extract It can be equalized or raised, and furthermore, it can be provided as a composition with high palatability.

More specifically, the composition for whitening teeth is to include fermented green laver extract, fermented seaweed extract, fermented dulce extract, fermented pintail extract and fermented stone agar extract.

In the case of using the fermented green laver extract, fermented seaweed extract, fermented dulce extract, fermented oleander extract, and fermented stone agar extract, there is an advantage that it can be used stably at a relatively high concentration due to low cytotoxicity. Acceptability can be increased.

Microorganisms used for the fermentation include Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus rhamnosus, Lactobacillus rhamnosus Lactobacillus plantarum), Lactobacillus helveticus, Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus casei, Lactobacillus casei, Lactobacillus casei Lactobacillus reuteri, Lactobacillus buchneri, Lactobacillus gasseri, Lactobacillus johonsonii, Lactobacillus kefir, Lactobacillus kefir, Lactobacillus kefir Cocos lactis (Lactococcus lactis), Lactococcus plantarum (Lactococcus plantarum), Lactococcus raffinolactis, Enterococcus faecalis (Enterococcus faecalis), Enterococcus faecium (Enterococcus faecium), Streptococcus faecium Lactobacillus such as Streptococcus thermophilus, Leuconostoc lactis, and Leukonostoc mesenteroides, and Bifidobacterium animals, Bifidobacterium bipidium (Bifidobacterium bifidum), Bifidobacterium breve (Bifidobact) erium breve), Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium pseudolongum, Bifidobacterium themophilum, Bifidobacterium It may include Bifidobacteria such as Bifidobacterium adolescentis, and more preferably Lactobacillus casei, Lactobacillus rhamnosus, Bifidobacterium Bifidobacterium bifidum) bifidobacterium, Bifidobacterium breve (Bifidobacterium breve) bifidobacteria, and Lactobacillus acidophilus (Lactobacillus acidophilus) It may be one or more selected from the group consisting of.

Preferably, the composition is based on 100 parts by weight of fermented green onion extract, 40 to 60 parts by weight of fermented seaweed extract, 30 to 40 parts by weight of fermented dulce extract, 30 to 40 parts by weight of fermented scallop extract, and 30 to 40 parts by weight of fermented rockfish extract It can be included as a wealth. In the case of the above range, a synergistic effect of critical significance is expressed as a synergistic effect due to the interaction of each extract, and when it is out of the above range, the synergistic effect is rapidly reduced or almost no synergistic effect.

In addition, there is no problem of side effects even if the dosage and duration of administration are increased with a food composition of natural substances.

More specifically, the composition is based on 100 parts by weight of fermented green laver extract, 40 to 60 parts by weight of fermented seaweed extract, 30 to 40 parts by weight of fermented dulce extract, 30 to 40 parts by weight of fermented Kosiraegi extract, 30 to 40 parts by weight of fermented rockfish extract It may be included in an amount of 20 parts by weight of xylitol, 10 parts by weight of glycerin, 0.1 parts by weight of peppermint essential oil, 10 parts by weight of glycerin, 10 parts by weight of calcium carbonate, and 7 parts by weight of xanthan gum.

The extract is extracted using an extraction solvent selected from the group consisting of water, C ₁ to C _{6 lower alcohols and mixtures thereof.}

Specifically, the step of pulverizing the seaweed in order to prepare the seaweed extract; Leaching the pulverized product using an organic solvent; Drying the sample after leaching; Re-leaching the dried sample using an organic solvent; Drying the sample after leaching; Leaching with water; And leaching to obtain a seaweed extract.

The seaweed extract extracted using the organic solvent may further include performing fractionation using an organic solvent.

The method of preparing the extract may be a conventional extraction method in the art, such as an ultrasonic extraction method, a leaching method, and a reflux extraction method. Specifically, it may be an extract obtained by extracting a natural product from which foreign matter has been removed by washing and drying with water, alcohol having 1 to 6 carbon atoms, or a mixed solvent thereof, and an extract obtained by sequentially applying the solvents to a sample.

The reflux extraction method is based on water, 100 mL of alcohol having 1 to 6 carbon atoms, 10 to 30 g of a pulverized product of a natural product, a reflux time of 1 to 3 hours, and 50 to 100% of alcohol or water having 1 to 6 carbon atoms. More specifically, based on 100 mL of alcohol having 1 to 6 carbon atoms or 100 mL of water, 10 to 20 g of a pulverized product of a natural product, a reflux time of 1 to 2 hours, and 70 to 90% of an alcohol or water having 1 to 4 carbon atoms .

The leaching method is performed at 15 to 30° C. for 24 to 72 hours, and water or an alcohol having 1 to 6 carbon atoms of 50 to 100% is used as an extraction solvent. More specifically, it proceeds for 20 to 25° C. for 30 to 54 hours, and the extraction solvent is made of water or an alcohol having 1 to 6 carbon atoms of 70 to 80%.

In the ultrasonic extraction method, the reaction proceeds at 30 to 50° C. for 0.5 to 2.5 hours, and the extraction solvent is made of water or an alcohol having 1 to 6 carbon atoms of 50 to 100%. Specifically, extraction is performed at 40 to 50° C. for 1 to 2.5 hours, and water or an alcohol having 1 to 6 carbon atoms of 70 to 80% is used as an extraction solvent.

The extraction solvent may be 2 to 50 times the weight of the sample, more specifically 2 to 20 times. For extraction, the sample may be left for 1 to 72 hours for leaching in the extraction solvent, and more specifically for 24 to 48 hours.

After extraction, the extract can be fractionated by sequentially applying a new fractionation solvent. The fractionation solvent used for fractionation is at least one selected from the group consisting of water, hexane, butanol, ethyl acetic acid, ethyl acetate, methylene chloride, and mixtures thereof, preferably ethyl acetate or methylene chloride.

After obtaining the extract or fraction, a method such as concentration or lyophilization may be additionally used.

The toothpaste for whitening according to another embodiment of the present invention is prepared by using a tooth whitening composition comprising the green seaweed extract as an active ingredient.

When the tooth whitening composition is used as a toothpaste, the composition may be added as it is to the toothpaste for whitening, or may be mixed or added with a functional food or a functional ingredient, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient may be appropriately determined according to the purpose of use.

The gargle solution according to another embodiment of the present invention is prepared by using a tooth whitening composition comprising the green seaweed extract as an active ingredient.

The gargling solution is defined as including all of a composition capable of gargling the oral cavity and other materials for exhibiting cleaning and antibacterial activity in the oral cavity. On the other hand, the gargle solution for achieving the object of the present invention should be an oil-based composition, and it is preferable not to mix a surfactant or allool. The specific formulation is defined as including all of the composition and mixing range that can be selected and mixed by a person having ordinary skill in the relevant field.

Oral spray according to another embodiment of the present invention is prepared using a tooth whitening composition comprising the green seaweed extract as an active ingredient.

According to the composition for whitening teeth of the present invention, using the seaweed extract containing the green seaweed extract, it does not contain hydrogen peroxide or titanium dioxide, and exhibits excellent teeth whitening effect and contains the green seaweed extract having excellent human stability as an active ingredient. It is possible to provide a composition for whitening teeth.

1 is an experiment result of a tooth brightness change amount of a tooth whitening composition comprising a green laver extract according to an embodiment of the present invention as an active ingredient.

Hereinafter, embodiments of the present invention will be described in detail so that those of ordinary skill in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[Production Example 1: Preparation of seaweed extract]

One. Preparation of green laver extract

The green laver was pulverized with a blender and then made into powder. A powder sample was added with 50% ethanol, an extraction solvent, at a ratio of 1;10 (w;v), and then completely immersed, and extracted three times for 3 hours while refluxing at 80°C. The extract is Whatman No. 2 Filtered with filter paper. The filtrate was concentrated under reduced pressure at 60° C. to prepare a green seaweed extract (PE).

2. Preparation of other seaweed extracts

Using the same method as the method for preparing the green seaweed extract (PE), a seaweed extract (UE), a dulce extract (DE), a pinworm extract (SE), and a stone agar extract (CE) were prepared.

3. Preparation of fermented green laver extract

Fermented green laver extract was prepared in order to enhance palatability with excellent flavor and taste while exhibiting tooth whitening effect. A mixture of DW 75% (w/w), powdered milk powder 15% (w/w) and green laver extract (PE) 10% (w/w) with the microorganism'Lactobacillus casei' used for fermentation After inoculation in the sterilized medium was cultured (25 ℃, 24 hours) to prepare a fermented green laver extract (PLc).

4. Preparation of other fermented seaweed extracts

Fermented seaweed extract (ULc), fermented dulce extract (DLc), fermented pinata extract (SLc), and fermented rockfish extract (CLc) were prepared using the same method as the method for preparing the fermented green laver extract (PLc).

[Production Example 2: Preparation of tooth whitening composition]

The green laver extract, seaweed extract, dulce extract, pinworm extract, and stone agar extract prepared in Preparation Example 1 were prepared as a composition for tooth whitening in the composition shown in Table 1 below.

MX1 MX2 MX3 MX4 MX5 MX6 MX7 MX8 MX9 MX10 MX11 MX12 PE 100 100 100 100 100 100 - - - - - - UE - 30 40 50 60 70 - - - - - - DE - - 20 30 40 50 - - - - - - SE - - 20 30 40 50 - - - - - - CE - - 20 30 40 50 - - - - - - PLc - - - - - - 100 100 100 100 100 100 ULc - - - - - - - 30 40 50 60 70 DLc - - - - - - - - 20 30 40 50 SLc - - - - - - - - 20 30 40 50 CLc - - - - - - - - 20 30 40 50

(Unit parts by weight, including 20 parts by weight of xylitol, 10 parts by weight of glycerin, 0.1 parts by weight of peppermint essential oil, 10 parts by weight of glycerin, 10 parts by weight of calcium carbonate, and 7 parts by weight of xanthan gum)

[Experimental Example 1: Evaluation of tooth whitening effect]

One. Tooth tone measurement

Five premolar and molar teeth extracted within the last 6 months were subjected to color tone measurement using VITA Easyshade. Thereafter, after uniformly applying the prepared tooth whitening compositions MX1 to MX12 for one week at intervals of 1 day, color tone measurement was performed. The tooth whitening effect was evaluated through the change in color tone before applying the tooth whitening composition and after evenly applying it for a week.

Measurement of teeth whitening effect Before application A week later Difference Average MX1 #One 7 6 -One -0.6 #2 7 8 One #3 13 12 -One #4 11 10 -One #5 10 9 -One MX2 #One 10 10 0 -0.8 #2 17 16 -One #3 13 12 -One #4 6 5 -One #5 8 7 -One MX3 #One 6 7 One -0.8 #2 7 7 0 #3 8 7 -One #4 17 16 -One #5 13 10 -3 MX4 #One 11 8 -3 -1.0 #2 8 8 0 #3 11 8 -3 #4 9 10 One #5 8 8 0 MX5 #One 11 9 -2 -1.2 #2 9 9 0 #3 10 7 -3 #4 10 11 One #5 8 6 -2 MX6 #One 7 7 0 -0.6 #2 8 7 -One #3 11 10 -One #4 5 7 2 #5 6 5 -One MX7 #One 6 7 One -0.8 #2 7 7 0 #3 8 7 -One #4 17 15 -2 #5 13 11 -2 MX8 #One 11 8 -3 -1.0 #2 8 7 -One #3 11 8 -3 #4 9 7 2 #5 8 8 0 MX9 #One 21 19 -2 -1.4 #2 17 16 -One #3 13 12 -One #4 15 13 -2 #5 15 14 -One MX10 #One 16 14 -2 -1.6 #2 9 8 -One #3 14 13 -One #4 8 8 0 #5 15 11 -4 MX11 #One 13 10 -3 -2.0 #2 8 6 -2 #3 10 7 -3 #4 9 7 -2 #5 7 7 0 MX12 #One 10 9 -One -1.4 #2 8 6 -2 #3 11 9 -2 #4 15 14 -One #5 14 13 -One

According to Table 2, it was confirmed that MX7 to MX12 had excellent teeth whitening effect compared to MX1 to MX6 that did not use the fermented extract. In particular, the average values of MX10 and MX11 showed the best tooth whitening effect.

Therefore, in the case of a tooth whitening composition in the range of MX10 and MX11 containing fermented seaweed extract, synergistic effect by mixing of each extract results in a synergistic effect more than a simple combination than containing only fermented green laver extract (PLc) You can see the fact.

2. The amount of change in tooth brightness

In order to check the effect of changing the brightness of the teeth of the prepared tooth whitening compositions MX1 to MX12, an artificially colored HAP disk was attached to the five premolar and molars extracted at the same time as the tooth tone measurement experiment, and removed after 1 hour. The amount of change in brightness compared to the initial stage was measured.

The results are shown in Fig. 1, and it was confirmed that the whitening effect was increased in the tooth whitening compositions MX7 to MX12 using fermented extracts compared to MX1 to MX6 without fermented extracts.

[Experimental Example 2: Sensory evaluation]

The composition for whitening teeth of MX4, MX5, MX10, and MX11 was divided into groups of 15 people, targeting 30 randomly. After using the composition for whitening of teeth, evaluation was conducted on the contents of the questionnaire shown in Table 3 below.

The results are shown in Table 4.

Contents of the survey 1. Less dry mouth 2. I feel refreshed 3. My mouth is not sticky. 4. The tooth color feels brighter. 5. The gum inflammation seems to have improved. 6. The surface of the tooth seems to be smooth. 7. It seems to be effective in whitening teeth.

Questionnaire 1 Question 2 Question 3 Question 4 Question 5 Question 6 Question 7 Group 1 MX4 7 7 8 8 8 5 8 MX5 8 7 8 9 4 4 10 Group 2 MX10 9 7 7 8 7 7 10 MX11 10 8 8 9 6 6 10

(Unit: index)

Table 4 shows the evaluation scores conducted on the contents of the questionnaire as shown in Table 3, and the higher the score, the better the evaluation. In particular, it was confirmed that it showed the best evaluation in'it seems to be effective for teeth whitening' in Question 7 Distinguishing the first group and the second group is that the sensory evaluation results were conducted depending on whether fermented extract was used in the tooth whitening composition. It was confirmed in the better evaluation.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of rights of

Claims (7)

Containing green laver extract as an active ingredient
Composition for whitening teeth. The method of claim 1,
The composition further comprises an extract of seaweed (Undaria pinnatifida)
Composition for whitening teeth. The method of claim 1,
The composition further comprises xylitol, peppermint essential oil, vegetable glycerin, an abrasive and a thickener.
Composition for whitening teeth. The method of claim 1,
The extract is extracted using an extraction solvent selected from the group consisting of water, C ₁ to C _{6 lower alcohol and mixtures thereof.}
Composition for whitening teeth. A toothpaste for whitening comprising the composition for whitening teeth according to any one of claims 1 to 4. A gargle solution comprising the composition for whitening teeth according to any one of claims 1 to 4. Oral spray comprising the composition for whitening teeth according to any one of claims 1 to 4.

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