KR20210008369A - 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트 - Google Patents

7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트 Download PDF

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KR20210008369A
KR20210008369A KR1020207034385A KR20207034385A KR20210008369A KR 20210008369 A KR20210008369 A KR 20210008369A KR 1020207034385 A KR1020207034385 A KR 1020207034385A KR 20207034385 A KR20207034385 A KR 20207034385A KR 20210008369 A KR20210008369 A KR 20210008369A
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oligonucleotide
oligonucleotide conjugate
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볼프강 르네르
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알파 아노메리끄 에스아에스
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020207034385A 2018-05-11 2019-05-10 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트 Ceased KR20210008369A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862670319P 2018-05-11 2018-05-11
US62/670,319 2018-05-11
PCT/EP2019/062064 WO2019215333A1 (en) 2018-05-11 2019-05-10 Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides

Publications (1)

Publication Number Publication Date
KR20210008369A true KR20210008369A (ko) 2021-01-21

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KR1020207034385A Ceased KR20210008369A (ko) 2018-05-11 2019-05-10 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트

Country Status (11)

Country Link
US (2) US20230132377A9 (https=)
EP (1) EP3790968A1 (https=)
JP (1) JP7665509B2 (https=)
KR (1) KR20210008369A (https=)
CN (1) CN112424352A (https=)
AU (1) AU2019266550A1 (https=)
BR (1) BR112020022620A2 (https=)
CA (1) CA3098266A1 (https=)
SG (1) SG11202010841QA (https=)
WO (1) WO2019215333A1 (https=)
ZA (1) ZA202007564B (https=)

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EP3330276A1 (en) * 2016-11-30 2018-06-06 Universität Bern Novel bicyclic nucleosides and oligomers prepared therefrom
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CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
WO2021054370A1 (ja) * 2019-09-18 2021-03-25 国立大学法人東京医科歯科大学 核酸複合体
WO2022058386A1 (en) * 2020-09-16 2022-03-24 Astrazeneca Ab Oligonucleotides conjugated to fatty acids
EP4247949A1 (en) 2020-11-23 2023-09-27 Alpha Anomeric SAS Nucleic acid duplexes
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
JP2024525608A (ja) 2021-07-09 2024-07-12 ダイン セラピューティクス，インコーポレーテッド ジストロフィン異常症を処置するための筋標的化複合体および製剤
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
CR20250257A (es) 2022-12-02 2025-08-28 Shanghai Argo Biopharmaceutical Co Ltd Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos
WO2025217304A1 (en) * 2024-04-09 2025-10-16 Bio-Rad Laboratories, Inc. Compositions and methods for detection of contaminant enzymes

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EP3330276A1 (en) 2016-11-30 2018-06-06 Universität Bern Novel bicyclic nucleosides and oligomers prepared therefrom

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US20220017898A1 (en) 2022-01-20
JP7665509B2 (ja) 2025-04-21
WO2019215333A1 (en) 2019-11-14
AU2019266550A1 (en) 2020-11-26
BR112020022620A2 (pt) 2021-02-17
EP3790968A1 (en) 2021-03-17
US20250250565A1 (en) 2025-08-07
US20230132377A9 (en) 2023-04-27
ZA202007564B (en) 2021-10-27
JP2021522862A (ja) 2021-09-02
CN112424352A (zh) 2021-02-26
CA3098266A1 (en) 2019-11-14
SG11202010841QA (en) 2020-11-27

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