KR20210008369A - 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트 - Google Patents

7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트 Download PDF

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KR20210008369A
KR20210008369A KR1020207034385A KR20207034385A KR20210008369A KR 20210008369 A KR20210008369 A KR 20210008369A KR 1020207034385 A KR1020207034385 A KR 1020207034385A KR 20207034385 A KR20207034385 A KR 20207034385A KR 20210008369 A KR20210008369 A KR 20210008369A
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oligonucleotide
oligonucleotide conjugate
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볼프강 르네르
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알파 아노메리끄 에스아에스
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
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    • C12N2320/00—Applications; Uses
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  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
KR1020207034385A 2018-05-11 2019-05-10 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트 Ceased KR20210008369A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862670319P 2018-05-11 2018-05-11
US62/670,319 2018-05-11
PCT/EP2019/062064 WO2019215333A1 (en) 2018-05-11 2019-05-10 Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides

Publications (1)

Publication Number Publication Date
KR20210008369A true KR20210008369A (ko) 2021-01-21

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KR1020207034385A Ceased KR20210008369A (ko) 2018-05-11 2019-05-10 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트

Country Status (11)

Country Link
US (2) US20230132377A9 (https=)
EP (1) EP3790968A1 (https=)
JP (1) JP7665509B2 (https=)
KR (1) KR20210008369A (https=)
CN (1) CN112424352A (https=)
AU (1) AU2019266550A1 (https=)
BR (1) BR112020022620A2 (https=)
CA (1) CA3098266A1 (https=)
SG (1) SG11202010841QA (https=)
WO (1) WO2019215333A1 (https=)
ZA (1) ZA202007564B (https=)

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EP3330276A1 (en) * 2016-11-30 2018-06-06 Universität Bern Novel bicyclic nucleosides and oligomers prepared therefrom
WO2019217459A1 (en) 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US20220193250A1 (en) 2018-08-02 2022-06-23 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
EP3829595A4 (en) 2018-08-02 2022-08-24 Dyne Therapeutics, Inc. MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES
US20220370491A1 (en) * 2019-09-18 2022-11-24 National University Corporation Tokyo Medical And Dental University Nucleic acid complex
EP4213883A1 (en) * 2020-09-16 2023-07-26 Astrazeneca AB Oligonucleotides conjugated to fatty acids
WO2022106695A1 (en) 2020-11-23 2022-05-27 Alpha Anomeric Sas Nucleic acid duplexes
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
IL309936A (en) 2021-07-09 2024-03-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of dystrophinopathy
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
CN120225676A (zh) 2022-12-02 2025-06-27 上海舶望制药有限公司 双环脱碱基核酸类似物以及由它们制备的寡聚化合物
WO2025217304A1 (en) * 2024-04-09 2025-10-16 Bio-Rad Laboratories, Inc. Compositions and methods for detection of contaminant enzymes

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US20220017898A1 (en) 2022-01-20
JP7665509B2 (ja) 2025-04-21
US20230132377A9 (en) 2023-04-27
BR112020022620A2 (pt) 2021-02-17
CA3098266A1 (en) 2019-11-14
US20250250565A1 (en) 2025-08-07
EP3790968A1 (en) 2021-03-17
SG11202010841QA (en) 2020-11-27
ZA202007564B (en) 2021-10-27
AU2019266550A1 (en) 2020-11-26
CN112424352A (zh) 2021-02-26
JP2021522862A (ja) 2021-09-02
WO2019215333A1 (en) 2019-11-14

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