CN112424352A - 包括7′-5′-α-异头双环糖核苷的寡核苷酸缀合物 - Google Patents

包括7′-5′-α-异头双环糖核苷的寡核苷酸缀合物 Download PDF

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CN112424352A
CN112424352A CN201980046260.3A CN201980046260A CN112424352A CN 112424352 A CN112424352 A CN 112424352A CN 201980046260 A CN201980046260 A CN 201980046260A CN 112424352 A CN112424352 A CN 112424352A
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arom
oligonucleotide
oligonucleotide conjugate
dcm
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W·伦纳
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Alpha Anomeric
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    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
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    • C12N2320/00—Applications; Uses
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    • C12N2320/33—Alteration of splicing

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201980046260.3A 2018-05-11 2019-05-10 包括7′-5′-α-异头双环糖核苷的寡核苷酸缀合物 Pending CN112424352A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862670319P 2018-05-11 2018-05-11
US62/670,319 2018-05-11
PCT/EP2019/062064 WO2019215333A1 (en) 2018-05-11 2019-05-10 Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides

Publications (1)

Publication Number Publication Date
CN112424352A true CN112424352A (zh) 2021-02-26

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CN201980046260.3A Pending CN112424352A (zh) 2018-05-11 2019-05-10 包括7′-5′-α-异头双环糖核苷的寡核苷酸缀合物

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US (2) US20230132377A9 (https=)
EP (1) EP3790968A1 (https=)
JP (1) JP7665509B2 (https=)
KR (1) KR20210008369A (https=)
CN (1) CN112424352A (https=)
AU (1) AU2019266550A1 (https=)
BR (1) BR112020022620A2 (https=)
CA (1) CA3098266A1 (https=)
SG (1) SG11202010841QA (https=)
WO (1) WO2019215333A1 (https=)
ZA (1) ZA202007564B (https=)

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WO2019217459A1 (en) 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US20220193250A1 (en) 2018-08-02 2022-06-23 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
EP3829595A4 (en) 2018-08-02 2022-08-24 Dyne Therapeutics, Inc. MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES
US20220370491A1 (en) * 2019-09-18 2022-11-24 National University Corporation Tokyo Medical And Dental University Nucleic acid complex
EP4213883A1 (en) * 2020-09-16 2023-07-26 Astrazeneca AB Oligonucleotides conjugated to fatty acids
WO2022106695A1 (en) 2020-11-23 2022-05-27 Alpha Anomeric Sas Nucleic acid duplexes
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
IL309936A (en) 2021-07-09 2024-03-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of dystrophinopathy
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
CN120225676A (zh) 2022-12-02 2025-06-27 上海舶望制药有限公司 双环脱碱基核酸类似物以及由它们制备的寡聚化合物
WO2025217304A1 (en) * 2024-04-09 2025-10-16 Bio-Rad Laboratories, Inc. Compositions and methods for detection of contaminant enzymes

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WO2010036698A1 (en) * 2008-09-24 2010-04-01 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
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US20220017898A1 (en) 2022-01-20
JP7665509B2 (ja) 2025-04-21
US20230132377A9 (en) 2023-04-27
BR112020022620A2 (pt) 2021-02-17
CA3098266A1 (en) 2019-11-14
KR20210008369A (ko) 2021-01-21
US20250250565A1 (en) 2025-08-07
EP3790968A1 (en) 2021-03-17
SG11202010841QA (en) 2020-11-27
ZA202007564B (en) 2021-10-27
AU2019266550A1 (en) 2020-11-26
JP2021522862A (ja) 2021-09-02
WO2019215333A1 (en) 2019-11-14

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