KR20210006151A - A composition for blue light interception comprising Senna alexandrina extract - Google Patents
A composition for blue light interception comprising Senna alexandrina extract Download PDFInfo
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- KR20210006151A KR20210006151A KR1020190082065A KR20190082065A KR20210006151A KR 20210006151 A KR20210006151 A KR 20210006151A KR 1020190082065 A KR1020190082065 A KR 1020190082065A KR 20190082065 A KR20190082065 A KR 20190082065A KR 20210006151 A KR20210006151 A KR 20210006151A
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- senna
- blue light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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Abstract
Description
본 발명은 센나 추출물을 유효성분으로 함유하는 블루라이트 차단용 조성물에 관한 것이다.The present invention relates to a composition for blocking blue light containing senna extract as an active ingredient.
피부는 우리 몸의 가장 큰 기관으로써 외부에 노출되어 있어 외부 자극으로부터 신체를 보호하는 역할을 한다. 여러 외부 자극 중 햇빛에 의한 광 손상이 가장 잘 알려져 있다. The skin is the largest organ of our body and is exposed to the outside, so it protects the body from external stimuli. Among several external stimuli, light damage caused by sunlight is the best known.
대표적인 광 손상 방지를 위해서는 일반적으로 자외선 차단제가 널리 사용되고 있다. 그러나 일반적인 자외선 차단제로 광 차단 효과를 기대할 수 없는 영역으로서 블루라이트의 차단이 제대로 이루어지지 않는 자외선 차단제로 인해 이에 관한 관심이 증가되고 있다.In order to prevent typical light damage, sunscreens are generally widely used. However, interest in this area is increasing due to the sunscreen that does not properly block blue light as a region where light blocking effects cannot be expected with a general sunscreen.
최근에는 TV, 컴퓨터, 스마트폰 등의 전자기기의 디스플레이와 LED 조명기기 등에 의한 블루라이트가 피부에 미치는 유해성에 대한 많은 연구가 진행되고 있다(Liebmann J., et al., J. Invest. Dermatol. 130(1), 259-269 (2010); Nakashima Y., et al., Free Radic. Bio. Med. 108, 300-310(2017)). Recently, many studies on the harmfulness of blue light to the skin by displays of electronic devices such as TVs, computers, and smart phones and LED lighting devices have been conducted (Liebmann J., et al., J. Invest. Dermatol. 130(1), 259-269 (2010); Nakashima Y., et al., Free Radic. Bio. Med. 108, 300-310 (2017)).
블루라이트란 가시광선 영역에서 푸른색 계열의 빛으로 높은 에너지를 갖는 400~500 nm 파장의 빛이다. 한국안광학회지에서는 좀 더 엄밀하게 블루라이트를 자색광(400 nm)과 청색광(460 nm)사이에 있어서 보랏빛이 감도는 부분이라고 한다(J Korean Opthalmic Opt Soc. 23(1), 57-63 (2018)). 블루라이트는 태양의 자외선보다 더 깊은 피부 층에 침투하기 때문에 활성산소(ROS)를 생성하고, 세포의 미토콘드리아 DNA 손상, 세포 기능장애, 세포 노화를 야기한다고 보고 있다(Godley BF. et al., J. Biol. Chem. 280(22), 21061-21066 (2005)). Blue light is light of a wavelength of 400 to 500 nm with high energy as blue light in the visible region. The Journal of the Korean Ophthalmic Optics Society more strictly refers to the part where the violet light is sensitive between the purple light (400 nm) and the blue light (460 nm) (J Korean Opthalmic Opt Soc. 23(1), 57-63 (2018) )). Because blue light penetrates deeper layers of the skin than the sun's ultraviolet rays, it generates reactive oxygen species (ROS), and is reported to cause damage to the mitochondrial DNA of cells, cell dysfunction, and cell aging (Godley BF. et al., J. Biol. Chem. 280(22), 21061-21066 (2005)).
세포는 직·간접적으로 생성된 자유 라디칼은 피부 세포의 단백질, 지질 등을 산화시키거나 DNA를 파괴시켜 세포사멸 또는 피부암을 유발하게 한다(Kang, S., et al., Am. J. Pathol., 166, 1691-1699(2005); Matsumura, Y., at al., Toxicol. Appl. Pharmacol., 195(3), 298-308(2004)).Free radicals generated directly or indirectly in cells cause apoptosis or skin cancer by oxidizing proteins and lipids of skin cells or destroying DNA (Kang, S., et al., Am. J. Pathol. , 166, 1691-1699 (2005); Matsumura, Y., at al., Toxicol. Appl. Pharmacol., 195(3), 298-308 (2004)).
일반적으로, 세포 내 항산화 효소들은 산화적 손상으로부터 보호하기 위하여 서로 상호작용을 형성한다. 산화적 스트레스는 자유 라디칼이 세포 내의 항산화 효소간 상호작용하는 능력을 초과할 때 형성된다. 산화적 스트레스는 염증 및 광 손상의 병리 과정에서 중요한 역할을 하는 것으로 보고된 바 있다(Simon R. et al., 49, 1603-1616(2010); Afaq F., et al., Experimentla Dematology, 15, 678-684(2006)) 따라서 블루라이트 파장을 흡수파장 및 항산화능을 확인함으로써 피부세포의 손상을 예방효과를 가질 수 있다.In general, antioxidant enzymes in cells interact with each other to protect against oxidative damage. Oxidative stress is formed when free radicals exceed their ability to interact with antioxidant enzymes in cells. Oxidative stress has been reported to play an important role in the pathological process of inflammation and light damage (Simon R. et al., 49, 1603-1616 (2010); Afaq F., et al., Experimentla Dematology, 15 , 678-684 (2006)) Therefore, it is possible to prevent damage to skin cells by checking the absorption wavelength and antioxidant activity of the blue light wavelength.
최근, 스피루리나, 황칠나무 부정근 분획물, 빌베리 등의 식물 추출물은 항산화 또는 블루라이트 흡수 등의 효과를 가지고 있으며, 블루라이트로부터 손상을 개선한다고 알려져 있다(대한민국 특허등록 10-1851623호, 대한민국 특허등록 10-1918939호, Ogawa K., et al., BMC Complement. Altern. Med., 14, 120-131(2014)). Recently, plant extracts such as Spirulina, Hwangchil tree adventitious root fraction, and bilberry have effects such as antioxidant or blue light absorption, and are known to improve damage from blue light (Korean Patent Registration No. 10-1851623, Korean Patent Registration 10- 1918939, Ogawa K., et al., BMC Complement. Altern. Med., 14, 120-131 (2014)).
센나(Senna alexandrina Mill)는 콩과의 관목으로 아프리카와 인도가 원산지이다. 높이는 1 m까지 자라는 아관목이다. 줄기는 녹색이며 잎은 깃꼴 ?횬纛막? 둥근 타원형으로 가장자리는 톱니가 없이 밋밋하고, 두꺼운 편이다. 꽃은 3~4월에 황색으로 산방화서로 달린다. 열매는 협과로 초여름에 녹색이나 마르면 갈색이 된다. Senna alexandrina Mill is a leguminous shrub native to Africa and India. It is a subshrub that grows up to 1 m in height. The stem is green and the leaves are pinnate? It is round and oval, and the edges are flat and thick without teeth. Flowers are yellow in March-April and run as corymbs. The fruit is a narrow fruit, green in early summer, but brown when dried.
대한민국 특허등록 제10-1121008호는 보습 및 진피 강화 효과가 우수한 화장료 조성물을 개시하고 있고, 대한민국 특허공개 제10-1587443호는 센나 추출물, 티네블린글루코사이드를 함유하는 피부노화 방지 및 주름개선용 화장료 조성물을 개시한 바 있다. Korean Patent Registration No. 10-1121008 discloses a cosmetic composition with excellent moisturizing and dermal strengthening effects, and Korean Patent Publication No. 10-1587443 is a cosmetic composition for preventing skin aging and improving wrinkles containing senna extract and tineblin glucoside. Has been disclosed.
또한, 일본특허공개 제2002-255733호 등에서는 일부 센나잎 추출물이 자외선 차단 효과가 있는 것으로 제안하고 있다. 이것은 자외선 영역에 국한되어 일반적으로 블루라이트 차단 효과는 전혀 기대할 수 없는 것으로 인식되었다,In addition, Japanese Patent Laid-Open No. 2002-255733 and the like suggest that some senna leaf extracts have a UV blocking effect. This is limited to the ultraviolet region, and it was generally recognized that the blue light blocking effect could not be expected at all.
그러나 지금까지 알려진 센나 추출물의 블루라이트 차단용 조성물에 대해서는 알려진 바가 없다. However, there is no known blue light blocking composition of Senna extract known so far.
위와 같이, 본 발명은 종래 알려진 바 없는 새로운 블루라이트 차단용 소재를 개발하여 보다 효과적으로 피부 영향을 받지 않도록 하는 소재의 제공을 해결과제로 한다.As described above, the present invention is to develop a new material for blocking blue light, which is not known in the art, to provide a material that prevents skin from being affected more effectively.
따라서 본 발명의 목적은 센나 추출물을 이용하여 블루라이트 차단용 조성물을 제공하는데 있다.Accordingly, an object of the present invention is to provide a composition for blocking blue light using senna extract.
또한, 본 발명의 다른 목적은 센나 추출물을 이용한 블루라이트 차단용 화장료 조성물을 제공하는데 있다.In addition, another object of the present invention is to provide a cosmetic composition for blocking blue light using senna extract.
또한, 본 발명의 또 다른 목적은 센나 추출물의 피부적용을 위한 광손상 예방과 치료용 의약적 용도를 제공하는데 있다.In addition, another object of the present invention is to provide a pharmaceutical use for the prevention and treatment of light damage for skin application of senna extract.
또한, 본 발명의 또 다른 목적은 센나로부터 추출 과정을 거쳐 제조되는 블루라이트 차단용 조성물의 제조방법을 제공하는데 있다.In addition, another object of the present invention is to provide a method of preparing a blue light blocking composition prepared through an extraction process from senna.
상기와 같은 본 발명의 과제 해결을 위하여, 본 발명은 센나(Senna alexandrina) 추출물을 유효성분으로 함유하는 블루라이트 차단용 조성물을 제공한다.In order to solve the problems of the present invention as described above, the present invention provides a composition for blocking blue light containing Senna alexandrina extract as an active ingredient.
또한, 본 발명은 센나 추출물을 유효성분으로 함유하는 블루라이트 차단용 화장료 조성물을 제공한다.In addition, the present invention provides a cosmetic composition for blocking blue light containing senna extract as an active ingredient.
또한, 본 발명은 센나 추출물을 유효성분으로 포함하는 블루라이트에 의한 피부 광손상 예방 및 회복을 위한 화장료 조성물을 제공한다.In addition, the present invention provides a cosmetic composition for preventing and recovering skin light damage caused by blue light, comprising the senna extract as an active ingredient.
또한, 본 발명은 센나 추출물을 유효성분으로 포함하는 블루라이트에 의한 피부 광손상 예방 및 회복을 위한 식음료 조성물을 제공한다.In addition, the present invention provides a food and beverage composition for preventing and recovering from skin light damage caused by blue light, comprising a senna extract as an active ingredient.
또한, 본 발명은 센나추출물을 블루라이트 차단을 위한 유효성분으로 함유하는 블루라이트에 의한 피부 질환 예방 및 치료용 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for preventing and treating skin diseases caused by blue light containing senna extract as an active ingredient for blocking blue light.
또한, 본 발명은 센나 추출물을 유효성분으로 포함하는 블루라이트에 의한 피부 광손상 예방 및 치료를 위한 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for the prevention and treatment of skin light damage caused by blue light, comprising the senna extract as an active ingredient.
또한, 본 발명은 센나를 물, 탄소수 1 내지 6의 알코올 또는 알코올수용액을 이용하여 추출하는 것을 특징으로 하는 센나 추출물을 함유하는 블루라이트 차단용 조성물의 제조방법을 제공한다.In addition, the present invention provides a method for producing a composition for blocking blue light containing senna extract, characterized in that the senna is extracted using water, an alcohol having 1 to 6 carbon atoms, or an aqueous alcohol solution.
본 발명에 따른 센나 추출물로 이루어진 블루라이트 차단용 화장료 조성물은 인간 섬유아세포에서 블루라이트 유발에 의한 세포손상에 대한 보호 효과와 활성산소종에 대한 소거능을 갖는다. 따라서 세포사멸을 감소시키고 세포생존율을 회복시킴으로써 블루라이트 차단 효과를 나타낸다.The cosmetic composition for blocking blue light comprising the senna extract according to the present invention has a protective effect against cell damage caused by blue light in human fibroblasts and a scavenging ability against reactive oxygen species. Therefore, it shows a blue light blocking effect by reducing apoptosis and restoring cell viability.
그러므로 본 발명의 센나 추출물은 블루라이트에 의한 피부의 광손상 치료 및 예방용 약학적 조성물과 광손상 회복 및 예방용 화장료 조성물의 원료로 유용하게 사용될 수 있는 효과가 있다.Therefore, the senna extract of the present invention has an effect that can be usefully used as a raw material for a pharmaceutical composition for treating and preventing photodamage of the skin caused by blue light, and a cosmetic composition for recovering and preventing photodamage.
또한, 본 발명은 이러한 블루라이트 차단 효과로 인하여 광손상 예방, 회복 등을 위한 식음료 조성물로서도 유용한 효과가 있다.In addition, the present invention has a useful effect as a food and beverage composition for preventing and recovering light damage due to such a blue light blocking effect.
도 1은 본 발명의 실시예에 따른 센나잎 추출물에 대한 불루라이트 차단 효과 실험 결과를 나타낸 사진이다.1 is a photograph showing the result of an experiment for blocking blulite effect on senna leaf extract according to an embodiment of the present invention.
이하, 본 발명을 하나의 구현예로서 더욱 상세하게 설명하면 다음과 같다.Hereinafter, the present invention will be described in more detail as one embodiment.
본 발명은 센나 추출물을 유효성분으로 함유하는 블루라이트 차단용 조성물에 관한 것이다.The present invention relates to a composition for blocking blue light containing senna extract as an active ingredient.
본 발명에서 사용되는 센나(Alexandrian Senna, Senna alexandrina)는 센노사이드 성분을 함유하고 있다. 모든 안트라키논 종류는 장관벽을 자극하고 배변을 촉진하지만, 습관성이 되기 쉬우므로 이 허브의 사용은 권하지 않는다. 센나만 사용하면 복통을 일으키므로 일반적으로 생강이나 펜넬, 코리안더, 딜, 오렌지껍질, 감초 등의 방향성 허브나 소화기능을 증진하는 허브와 섞어서 사용한다. 잎과 협과는 하부의 소화기관을 청소하고 자극하므로 단식용으로도 쓰인다. Senna (Alexandrian Senna, Senna alexandrina) used in the present invention contains a sennoside component. All anthracinone types stimulate the intestinal wall and promote bowel movements, but the use of this herb is not recommended as it is prone to habitability. Since senna alone causes abdominal pain, it is generally used in combination with aromatic herbs such as ginger, fennel, coriander, dill, orange peel, licorice, or herbs that improve digestive function. The leaves and conifers clean and stimulate the digestive system in the lower part, so they are also used for fasting.
본 발명에서 원료로 사용되는 센나는 센나잎, 센나꽃, 센나열매, 센나뿌리 중에서 하나이상을 포함하는 것으로 한다. 센나 추출물은 센나잎, 센나꽃, 센나열매, 센나뿌리 중에서 선택된 하나 이상의 추출물 또는 이들 중 하나 이상의 건조분말을 포함할 수 있다. 바람직하게는 센나잎 또는 센나열매의 추출물이 사용될 수 있다. 가장 바람직하게는 센나잎 추출물이 사용될 수 있다. 그러므로 본 발명에서 추출물은 센나를 그대로, 건조하여 또는 분쇄한 후에 극성용매로 추출한 추출물과 센나의 건조분말을 포함하는 것을 의미한다.Senna used as a raw material in the present invention is to contain one or more of senna leaf, senna flower, senna fruit, and senna root. The senna extract may include one or more extracts selected from senna leaf, senna flower, senna fruit, and senna root, or at least one dry powder of these. Preferably, an extract of senna leaf or senna fruit may be used. Most preferably, senna leaf extract may be used. Therefore, in the present invention, the extract is meant to include the extract extracted with a polar solvent and dried powder of senna after drying or pulverizing senna as it is.
본 발명에서는 센나 추출물은 전형적으로는 센나의 극성용매 추출물이 바람직하게 이용될 수 있다.In the present invention, the senna extract is typically a polar solvent extract of senna may be preferably used.
본 발명은 센나 추출물을 블루라이트 차단용의 새로운 용도를 가진 유효성분으로 함유하는 조성물을 특징으로 한다.The present invention features a composition containing senna extract as an active ingredient with a new use for blocking blue light.
본 발명에서 센나 추출물의 블루라이트 차단이라고 하는 효과는 블루라이트의 차단 또는 흡수를 통해 실질적으로 통과를 억제 또는 감소시키는 것을 모두 포함하는 것으로 해석되며, 바람직하게도 400 ~ 500 nm 파장의 블루라이트의 통과를 감소시켜 피부세포를 보호한다. 전형적으로는 블루라이트의 흡수 등으로 차단 효과를 발휘하는 것으로 이해된다. 이러한 400 ~ 500 nm 파장 영역은 눈으로 보이는 가시광선 영역으로서 블루라이트가 이에 해당한다. 그러므로 이러한 블루라이트 차단 효과는 일반적인 자외선 파장영역인 270 nm 이하나, 270 ~ 350 nm 파장 영역의 자외선 차단 효과와는 전혀 다른 작용기전을 나타낸다는 것을 의미한다.In the present invention, the effect of blocking blue light of the senna extract is interpreted to include all of substantially inhibiting or reducing the passage through blocking or absorption of blue light, and preferably, the passage of blue light having a wavelength of 400 to 500 nm Reduces skin cells to protect. Typically, it is understood that it exerts a blocking effect by absorption of blue light or the like. The 400 ~ 500 nm wavelength region is a visible ray region visible to the eye, and blue light corresponds to this. Therefore, this blue light blocking effect means that it exhibits a completely different mechanism of action from the UV blocking effect in the general ultraviolet wavelength range of 270 nm or less, but 270 ~ 350 nm wavelength range.
따라서 본 발명의 바람직한 구현예에 따르면, 본 발명은 센나 추출물을 종래와는 달리 400 ~ 500 nm 파장영역의 블루라이트 차단용의 새로운 용도로 바람직하게 적용될 수 있다.Therefore, according to a preferred embodiment of the present invention, the present invention can be preferably applied to a new use for blocking blue light in the 400 ~ 500 nm wavelength region unlike the conventional senna extract.
본 발명에 따른 센나 추출물은 블루라이트 차단의 기능 또는 블루라이트로부터 파생되는 피부에 대한 부적절한 반응과 및 피부 질환과 관련된 문제를 본질적으로 해결하거나 도움을 주는 화장료 조성물이나 식음료 조성물, 약학적 조성물로서 유용하다.The senna extract according to the present invention is useful as a cosmetic composition, food and beverage composition, or pharmaceutical composition that essentially solves or helps with the function of blocking blue light or inappropriate reactions to the skin derived from blue light and problems related to skin diseases. .
본 발명의 바람직한 구현예에 따르면, 이러한 블루라이트 차단용 조성물은 블루라이트 차단을 위한 유효성분으로 함유되는 화장료 조성물, 식음료 조성물 또는 약학적 조성물의 용도로 사용될 수 있다According to a preferred embodiment of the present invention, such a composition for blocking blue light can be used as a cosmetic composition, food and beverage composition, or pharmaceutical composition contained as an active ingredient for blocking blue light.
본 발명의 바람직한 구현예에 따르면, 블루라이트 차단용 조성물은 다른 성분들과 혼합하여 기능성 화장료 조성물로 사용될 수 있다.According to a preferred embodiment of the present invention, the composition for blocking blue light may be used as a functional cosmetic composition by mixing with other ingredients.
또한, 본 발명의 바람직한 구현예에 따르면, 센나 추출물을 블루라이트 차단의 유효성분으로서 함유하는 블루라이트에 의한 피부 질환 예방 및 치료용 또는 피부 광손상 예방 및 치료를 위한 약학적 조성물로 구성될 수 있다.In addition, according to a preferred embodiment of the present invention, it may be composed of a pharmaceutical composition for preventing and treating skin diseases caused by blue light or for preventing and treating skin light damage, containing senna extract as an active ingredient for blocking blue light. .
본 발명의 바람직한 구현예에 따르면, 상기 화장료 조성물이나 식음료 조성물, 약학적 조성물은 통상적으로 화장료, 식음료 또는 약학조성물에 사용되는 첨가제나 부형제 또는 다른 효능을 가진 성분과 혼합된 형태로 이루어질 수 있다.According to a preferred embodiment of the present invention, the cosmetic composition, food and beverage composition, or pharmaceutical composition may be formed in a mixed form with additives or excipients or ingredients having other effects that are commonly used in cosmetics, food and beverage or pharmaceutical compositions.
본 발명의 바람직한 구현예에 따르면, 상기 화장료 조성물의 경우 센나 추출물을 0.1 ~ 20중량%, 더욱 바람직하게는 0.5 ~ 5중량%로 함유할 수 있다.According to a preferred embodiment of the present invention, the cosmetic composition may contain 0.1 to 20% by weight, more preferably 0.5 to 5% by weight of senna extract.
본 발명의 바람직한 구현예에 따르면, 상기 식음료 조성물의 경우 센나 추출물을 0.1 ~ 20중량%, 더욱 바람직하게는 0.5 ~ 5중량%로 함유할 수 있다.According to a preferred embodiment of the present invention, in the case of the food and beverage composition, the senna extract may be contained in an amount of 0.1 to 20% by weight, more preferably 0.5 to 5% by weight.
본 발명의 바람직한 구현예에 따르면, 상기 약학적 조성물의 경우 센나 추출물을 1 ~ 30중량%, 더욱 바람직하게는 3 ~ 15중량%로 함유할 수 있다.According to a preferred embodiment of the present invention, the pharmaceutical composition may contain 1 to 30% by weight of senna extract, more preferably 3 to 15% by weight.
본 발명에 따른 센나 추출물을 함유하는 블루라이트 차단용 조성물은 센나를 극성용매로 추출하여 추출물을 제조하는 단계를 포함하여 제조될 수 있다.The composition for blocking blue light containing the senna extract according to the present invention may be prepared including the step of preparing an extract by extracting senna with a polar solvent.
본 발명의 바람직한 구현예에 따르면, 센나를 물, 탄소수 1 내지 6의 알코올 또는 알코올수용액을 이용하여 추출하여 센나 추출물을 제조할 수 있다.According to a preferred embodiment of the present invention, senna extract can be prepared by extracting senna using water, alcohol having 1 to 6 carbon atoms, or an aqueous alcohol solution.
본 발명의 바람직한 구현예에 따르면, 센나 추출물의 제조방법은 (a) 센나를 물, 탄소수 1 내지 4의 알코올 또는 알코올수용액을 이용하여 추출하는 단계; (b) 상기 (a)단계의 추출물에 탄수화물가수분해효소, 펙틴가수분해효소 및 셀룰로오스가수분해요소로 이루어진 군으로부터 선택된 어느 하나 이상을 가하고 진탕·배양하는 단계를 포함할 수 있다.According to a preferred embodiment of the present invention, a method for preparing senna extract includes the steps of: (a) extracting senna using water, alcohol having 1 to 4 carbon atoms, or an aqueous alcohol solution; (b) adding at least one selected from the group consisting of carbohydrate hydrolase, pectin hydrolyzing enzyme, and cellulose hydrolyzing urea to the extract of step (a), and shaking and culturing.
또한, 본 발명의 바람직한 구현예에 따르면, 추가적으로 (c) 상기 (b)단계의 배양물에 분획용 유기용매를 가하여 분획하는 단계를 포함하는 방법으로 센나 추출물을 제조할 수 있다.In addition, according to a preferred embodiment of the present invention, it is possible to additionally prepare a senna extract by a method comprising the step of (c) fractionating by adding an organic solvent for fractionation to the culture of step (b).
본 발명의 바람직한 구현예에 따르면, 센나 추출물은 가장 바람직하게는 센나잎 또는 센나잎 분쇄물을 이용하여 극성용매로 추출하여 얻어진 추출물이 바람직하게 이용될 수 있다.According to a preferred embodiment of the present invention, the senna extract is most preferably an extract obtained by extracting with a polar solvent using senna leaf or senna leaf pulverized product may be preferably used.
센나잎 추출물의 제조방법을 좀 더 구체적으로 설명하면, (a) 센나잎 또는 건조되고 분쇄된 센나잎을 더욱 바람직하게는 에탄올수용액, 메탄올수용액, 이소프로판올수용액, 부탄올수용액 등의 탄소수 1 내지 4의 알코올 또는 알코올수용액을 이용하여 추출하는 단계를 포함하며, 후속 단계인 (b)단계의 효소처리 과정이나 독성을 고려하면 에탄올수용액이 보다 바람직하다.In more detail, the method for preparing the senna leaf extract is described in more detail: (a) senna leaves or dried and crushed senna leaves are more preferably alcohols having 1 to 4 carbon atoms such as an aqueous ethanol solution, an aqueous methanol solution, an aqueous isopropanol solution, and an aqueous butanol solution Alternatively, it includes the step of extracting using an aqueous alcohol solution, and an aqueous ethanol solution is more preferable in consideration of the enzymatic treatment process or toxicity of the subsequent step (b).
또한, 상기 알코올수용액의 알코올 함량은 약 50 중량% 내지 약 100 중량%가 바람직하며, 약 75 중량% 내지 약 95 중량%가 더욱 바람직하다.In addition, the alcohol content of the aqueous alcohol solution is preferably about 50% by weight to about 100% by weight, more preferably about 75% by weight to about 95% by weight.
상기 (a)단계의 추출은 60-90℃에서 수행되는 것이 바람직한데, 온도가 너무 낮을 경우 추출 수율이 떨어지고, 추출 시간이 길어지며, 너무 높은 온도에서 추출할 경우 센나잎 추출물 성분들의 변성이 있을 수 있다.The extraction in step (a) is preferably carried out at 60-90°C. If the temperature is too low, the extraction yield decreases, the extraction time is lengthened, and if the extraction is too high, the senna leaf extract components may be denatured. I can.
센나잎 추출물의 블루라이트 차단 효과를 증대시키는 바람직한 제조방법은 또한, (b) 상기 (a)단계의 추출물에 탄수화물가수분해효소, 펙틴가수분해효소 및 셀룰로오스가수분해효소로 이루어진 군으로부터 선택된 어느 하나 이상을 가하고 진탕 배양하는 단계를 포함한다. 이러한 배양은 40 ~ 70℃에서 이루어지는 것이 바람직하다.A preferred method for increasing the blue light blocking effect of the senna leaf extract is also, (b) any one or more selected from the group consisting of carbohydrate hydrolase, pectin hydrolase and cellulose hydrolase in the extract of step (a). And adding and shaking culture. This culture is preferably made at 40 ~ 70 ℃.
상기 제조방법은 또한 효소를 이용한 (b)단계의 효율을 높이기 위하여 (a)단계와 (b)단계 사이에 (a)단계의 추출물을 농축하고, 농축물을 예컨대 에탄올수용액으로 다시 용해시키는 단계를 포함하는 것이 바람직하며, 상기 에탄올수용액은 에탄올의 함량이 (a)단계의 추출 단계보다 낮은 5 내지 30 중량%인 것이 바람직하며, 약 10 중량% 에탄올수용액인 것이 더욱 바람직하다.The manufacturing method also includes the steps of concentrating the extract of step (a) between steps (a) and (b) to increase the efficiency of step (b) using enzymes, and dissolving the concentrate again with, for example, an aqueous ethanol solution. It is preferable to include, and the ethanol aqueous solution is preferably 5 to 30 wt% lower than the extraction step of step (a), and more preferably about 10 wt% aqueous ethanol solution.
센나잎 추출물의 블루라이트 차단 효과를 증대시키는 바람직한 제조방법은 또한 추가적으로 (c) 상기 (b)단계의 배양물에 분획용 유기용매를 가하여 분획하는 단계를 포함하며, 이러한 분획용 유기용매로는 에틸아세테이트, 디에틸에테르, 트리클로로메탄, 부탄올 등이 단독으로 또는 1 이상을 혼합하여 사용될 수 있다.A preferred manufacturing method for enhancing the blue light blocking effect of the senna leaf extract further includes the step of fractionating by adding an organic solvent for fractionation to the culture of step (b), and the organic solvent for such fractionation is ethyl Acetate, diethyl ether, trichloromethane, butanol, and the like may be used alone or in combination of one or more.
본 발명에 따른 센나 추출물은 바람직하게도 센나잎 추출물은 물론 센나꽃, 센나열매, 센나줄기, 센나뿌리 등의 추출물에서도 유사한 효과를 나타낸다.The senna extract according to the present invention preferably exhibits similar effects in extracts such as senna leaf extract, senna flower, senna fruit, senna stem, and senna root.
그러므로 본 발명에서 센나잎 추출물로서 상세하게 설명하더라도 본 발명은 센나잎 만을 한정하지 않고 센나의 꽃, 열매, 줄기 및 뿌리의 중 하나 이상의 추출물에서도 블루라이트 차단 효과와 관련이 있다는 것을 포함한다.Therefore, even if described in detail as a senna leaf extract in the present invention, the present invention does not limit only the senna leaf, and includes that it is related to the blue light blocking effect in one or more extracts of senna flowers, fruits, stems and roots.
본 발명의 블루라이트 차단용 조성물에 포함되는 센나잎 추출물의 가장 바람직한 제조방법은 (a) 센나잎 또는 분쇄된 센나잎을 탄소수 1 내지 4의 알코올 또는 알코올수용액을 이용하여 추출하는 단계; (b) 상기 (a)단계의 추출물에 탄수화물가수분해효소, 펙틴가수분해효소 및 셀룰로오스가수분해요소로 이루어진 군으로부터 선택된 어느 하나 이상을 가하고 진탕·배양하는 단계; (c) 상기 (b)단계의 배양물에 분획용 유기용매를 가하여 분획하는 단계를 포함하는 제조방법에 의해 제조될 수 있다.The most preferred method for preparing the senna leaf extract contained in the composition for blocking blue light of the present invention includes the steps of: (a) extracting senna leaves or crushed senna leaves using alcohol or an alcohol aqueous solution having 1 to 4 carbon atoms; (b) adding at least one selected from the group consisting of carbohydrate hydrolase, pectin hydrolyzing enzyme, and cellulose hydrolyzing urea to the extract of step (a), and shaking and culturing; (c) it can be prepared by a manufacturing method comprising the step of fractionating by adding an organic solvent for fractionation to the culture of step (b).
본 발명의 블루라이트 차단용 조성물은 피부 광손상 치료 또는 예방용 약학적 조성물과 피부 광손상 예방 및 회복용 화장료 조성물의 제조에 이용될 수 있다.The composition for blocking blue light of the present invention may be used in the manufacture of a pharmaceutical composition for treating or preventing skin photodamage and a cosmetic composition for preventing and recovering skin photodamage.
본 발명에 따른 센나 추출물을 함유하는 약학적 조성물은 약학적 조성물의 제조에 통상적으로 사용되는 적절한 담체, 부형제 및 희석제를 더 포함할 수 있다. 본 발명의 실시예에 따른 약학적 조성물에 포함될 수 있는 약학적으로 허용 가능한 담체, 부형제 및 희석제는 락토오스, 덱스트로오스, 수크로오스, 칼슘 실리케이트, 셀룰로오스, 메틸셀룰로오스, 미정질 셀룰로오스, 폴리비닐피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 마그네슘스테아레이트 및 광물유를 포함하나, 이에 한정되지 않는다.The pharmaceutical composition containing the senna extract according to the present invention may further include suitable carriers, excipients, and diluents commonly used in the preparation of pharmaceutical compositions. Pharmaceutically acceptable carriers, excipients, and diluents that may be included in the pharmaceutical composition according to the embodiment of the present invention are lactose, dextrose, sucrose, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone , Water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oils, but are not limited thereto.
본 발명에 따른 약학적 조성물은 본 발명이 속하는 기술분야에서 공지된 통상의 방법에 따라 피부연고제, 피부도포용 액제는 물론, 경우용 제제로서 겔, 정제, 캡슐, 과립제, 현탁액, 시럽 등의 다양한 제형으로 제형화되어 사용될 수 있다.The pharmaceutical composition according to the present invention is a variety of gels, tablets, capsules, granules, suspensions, syrups, as well as skin ointments, liquids for skin application, as well as occasional preparations, according to conventional methods known in the art. It can be formulated into a formulation and used.
또한, 본 발명은 센나 추출물은 통상의 다양한 식음료용 성분과 혼합하여 식음료를 제조할 수 있다.In addition, in the present invention, the senna extract may be mixed with various conventional food and beverage ingredients to prepare food and beverages.
본 발명의 센나 추출물을 함유하는 화장료 조성물은 화장수류, 에센스류, 크림류, 팩류, 파운데이션류, 메이크업 베이스류 등과 같은 기초제품, 색조제품 및 두발제품의 다양한 제형으로 제조될 수 있다. 구체적으로 액상, 크림상, 페이스트상 및 고체상 등 다양한 성상으로 적용이 가능하며, 통상적인 화장료 제조법에 적용시킬 수 있다.The cosmetic composition containing the senna extract of the present invention can be prepared in various formulations of basic products, color products, and hair products such as lotions, essences, creams, packs, foundations, makeup bases, and the like. Specifically, it can be applied in a variety of properties such as liquid, cream, paste, and solid, and can be applied to conventional cosmetic preparation methods.
본 발명에 따른 센나 추출물을 유효성분으로 함유하는 블루라이트 차단용 조성물은 인간 섬유아세포에서 블루라이트 유발에 의한 세포손상에 대한 보호 효과가 우수하며, 특히 활성산소종에 대한 소거능을 갖는 것으로 확인되었다. The composition for blocking blue light containing the senna extract according to the present invention as an active ingredient has an excellent protective effect against cell damage caused by blue light in human fibroblasts, and was found to have a particularly scavenging ability against reactive oxygen species.
따라서 본 발명에 따른 센나 추출물은 블루라이트 자체의 차단은 물론 세포사멸을 감소시키고 세포생존율을 회복시킴으로써 블루라이트 차단 효과를 통해 피부질환의 예방과 치료 효과를 나타낸다.Therefore, the senna extract according to the present invention not only blocks blue light itself, but also reduces apoptosis and restores cell viability, thereby preventing and treating skin diseases through the blue light blocking effect.
특히, 본 발명의 센나 추출물은 블루라이트에 의한 피부의 광손상 치료 및 예방용 약학적 조성물과 광손상 회복 및 예방용 약제 조성물로 유용하다. 또한, 이와 유사하게 블루라이트 차단용 화장료 조성물의 원료, 다양한 화장료로 유용하게 사용될 수 있다. In particular, the senna extract of the present invention is useful as a pharmaceutical composition for the treatment and prevention of light damage to the skin caused by blue light and a pharmaceutical composition for recovery and prevention of light damage. In addition, similarly, it can be usefully used as a raw material for a cosmetic composition for blocking blue light, as well as a variety of cosmetics.
이하, 본 발명을 구체적으로 설명하기 위해 실시예, 실험예 등의 구체적인 예를 들어 설명하기로 한다. Hereinafter, in order to describe the present invention in detail, specific examples such as Examples and Experimental Examples will be described.
그러나 본 발명에 따른 실시예 또는 실험예들은 여러 가지 다른 형태로 변형될 수 있으며, 본 발명의 범위가 아래에서 상술하는 예들에 한정되는 것으로 해석되어지지 않아야 한다. 본 발명에 따른 실시예 및 실험예들은 당 업계에서 평균적인 지식을 가진 자에게 본 발명을 보다 완전하게 설명하기 위해서 제공 되어지는 것에 불과하므로, 본 출원 시점에 있어서 이들을 대체할 수 있는 다양한 균등물과 변형예들이 있을 수 있음을 이해하여야 한다.However, the embodiments or experimental examples according to the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the examples described below. Since the examples and experimental examples according to the present invention are only provided to more completely describe the present invention to a person with average knowledge in the art, various equivalents that can replace them at the time of the present application and It should be understood that there may be variations.
특히, 본 실시예와 실험예에서는 센나 추출물의 제조를 위해 대표적으로 센나잎을 이용하여 제조하여, 그 이외의 센나의 다른 부분들도 유사한 방법으로 실시될 수 있으므로 이를 포함하는 것으로 해석되어야 한다.In particular, in this Example and Experimental Example, the senna extract was prepared using senna leaves, and other parts of senna other than that may be performed in a similar manner, so it should be interpreted as including them.
실시예 : 센나잎 추출물의 제조Example: Preparation of senna leaf extract
건조된 센나잎 50 g을 분쇄한 후, 70% 에탄올 수용액 500 mL을 가하여 60~90℃에서 2시간 동안 가열추출하고 여과하였다. 이 추출과정을 2회 반복하고 농축하여 추출물을 얻었다. 상기 추출물을 DMSO (dimethyl sulfoxide)에 100 mg/mL로 용해시켜 스톡 용액을 제조하여 실험에 이용하였다.After pulverizing 50 g of dried senna leaves, 500 mL of 70% ethanol aqueous solution was added, heat-extracted at 60-90° C. for 2 hours, and filtered. This extraction process was repeated twice and concentrated to obtain an extract. The extract was dissolved in DMSO (dimethyl sulfoxide) at 100 mg/mL to prepare a stock solution and used in the experiment.
실험예 : 센나잎 추출물의 블루라이트 흡수 효과Experimental Example: Blue Light Absorption Effect of Senna Leaf Extract
블루라이트를 추출물이 포함된 큐빅에 조사하여 블루라이트 빛이 투과를 확인하였다. Blue light was irradiated to the cubic containing the extract to confirm the transmission of blue light.
그 결과를 첨부도면 도 1에 사진으로 나타내었다.The results are shown in photographs in the accompanying drawings.
도 1에서 보면, 상기 실시예에 따른 센나잎 추출물이 블루라이트를 차단효과를 보여준 것이다. 도 1의 왼쪽 그림에서 정제수가 들어 있는 큐빅에서는 블루라이트가 통과된다. 반면에, 오른쪽 그림의 센나잎 추출물이 포함된 큐빅은 블루라이트가 흡수되어 통과되지 않는 것으로 확인되었다. Referring to FIG. 1, the senna leaf extract according to the above example showed a blue light blocking effect. In the left figure of FIG. 1, blue light passes through the cubic containing purified water. On the other hand, it was confirmed that the cubic containing the senna leaf extract in the picture on the right absorbed blue light and did not pass.
따라서 이러한 실험을 통해 실시예의 센나잎 추출물이 블루라이트 차단효과가 있는 것으로 확인되었다.Therefore, through these experiments, it was confirmed that the senna leaf extract of Example has a blue light blocking effect.
실험예 2 : 센나잎 추출물의 항산화 효과Experimental Example 2: Antioxidant Effect of Senna Leaf Extract
상기 실시예의 센나잎 추출물에 대해 화장료 유효성분 물질로서의 항산화효과를 알아보기 위하여 자유라디칼소거실험(Free Radical Scavenging Activity Test)과 활성산소(superoxide anion)소거활성실험을 실시하였다. 자유라디칼소거시험은 Kim 등(Kor. J. Pharmacogn., 24 (4), 299~303(1993))의 방법을 변형한 것으로써, 안정한 자유라디칼인 DPPH(1,1-Diphenyl-2-picrylhydrazyl radical(Sigma)을 사용하였다. The Free Radical Scavenging Activity Test and the superoxide anion scavenging activity test were conducted in order to investigate the antioxidant effect of the senna leaf extract as a cosmetic active ingredient. The free radical scavenging test is a modification of the method of Kim et al. (Kor. J. Pharmacogn., 24 (4), 299-303 (1993)), and is a stable free radical DPPH (1,1-Diphenyl-2-picrylhydrazyl). radical (Sigma) was used.
먼저, 0.2mM DPPH 용액 1㎖에 상기 추출 실시예에 따라 수득된 생약재 추출물 시료를 메탄올에 적당한 농도로 희석하여 2㎖ 혼합하고, 실온에서 10분간 방치한 후 517nm에서 흡광도를 측정한다. First, in 1 ml of 0.2mM DPPH solution, 2 ml of a herbal extract sample obtained according to the above extraction example was diluted in methanol to an appropriate concentration, mixed with 2 ml, left at room temperature for 10 minutes, and absorbance was measured at 517 nm.
한편, 상기 자유라디칼소거시험에서의 대조군은 시료용액 대신 메탄올을 넣어 같은 방법으로 측정하며, DPPH 용액 대신 메탄올을 넣어 생약재 추출물 시료와 대조군에 대한 각각의 색 보정값을 얻는 것으로 설정하였다. On the other hand, the control group in the free radical scavenging test was measured by adding methanol instead of the sample solution, and methanol was added instead of the DPPH solution to obtain each color correction value for the herbal extract sample and the control group.
하기 수학식 1을 이용하여 자유라디칼소거율을 수치로 계산하여 하기 표 1에 나타내었다. 하기 표 1에서, SC50은 자유라디칼 소거율 50%를 달성하기 위해 소요되는 시료의 농도로서 다른 성분물질(대조군)과 상대적으로 비교할 때 사용하는 수치로서 값이 작을수록 소거율이 높음을 나타낸다. The free radical scavenging rate was calculated numerically using
[수학식 1][Equation 1]
SC50(mg)Free radical scavenging ability
SC 50 (mg)
실험예 3 : 센나잎 추출물의 세포독성실험Experimental Example 3: Cytotoxicity test of senna leaf extract
세포독성은 Moseman의 방법(Moseman T., J. Immuno. Methods, 65, 55(1983)) 및 Skaper 등의 방법(Skaper SD., et al., Cell Culture, 2, 17-33(1990))을 이용한 MTT (3-4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazolium bromide) 측정법을 이용하여 수행하였다. 인간 섬유아세포 HS68를 96 well plate에 배양하였다. Cytotoxicity was determined by Moseman's method (Moseman T., J. Immuno. Methods, 65, 55 (1983)) and Skaper et al. (Skaper SD., et al., Cell Culture, 2, 17-33 (1990)). MTT (3-4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazolium bromide) was carried out using a measurement method. Human fibroblasts HS68 were cultured in 96 well plates.
상기 실시예의 센나잎 추출물 처리 12시간 후, MTT 5 mg/mL 용액을 각 well에 처리한 후에 37℃에서 4시간 동안 반응시켰다. 12 hours after the senna leaf extract treatment of the above example, MTT 5 mg/mL solution was treated in each well and then reacted at 37° C. for 4 hours.
배지를 제거한 후 DMSO를 넣어 형성된 포마르잔 크리스탈을 녹여서 ELISA 판독기를 이용하여 595 nm에서 측정하였다. 세포에 대한 독성은 각각의 대조구의 평균 흡광도 값에 대한 백분율로 나타냈다.After removing the medium, DMSO was added to dissolve the formed formarzan crystal, and measured at 595 nm using an ELISA reader. Toxicity to cells was expressed as a percentage of the average absorbance value of each control.
섬유아세포에서 센나잎 추출물의 세포독성을 조사하기 위하여 1, 20, 50 μg/mL 농도의 센나잎 추출물을 처리하였을 때, 대조구인 DMSO만을 처리한 것과 비교하여 세포증식의 변화 정도를 계산하여 세포독성을 조사하였다. To investigate the cytotoxicity of senna leaf extract in fibroblasts, when treated with senna leaf extract at concentrations of 1, 20, and 50 μg/mL, the degree of change in cell proliferation was calculated compared to that treated with only DMSO, the control, and cytotoxicity. Was investigated.
그 결과는 Significant results according to students test (p < 0.05)로서, 첨부도면 도 2에 나타내었다. The results are Significant results according to students test (p <0.05), and are shown in Fig. 2 of the accompanying drawings.
이 결과에서 보면, 상기 실시예에 따른 센나잎 추출물을 섬유아세포에 처리했을 때 세포독성 유무를 보여준다. 여기서, 센나잎 추출물은 50 μg/mL까지 세포 독성이 없는 것으로 확인하였다.From this result, it shows the presence or absence of cytotoxicity when the senna leaf extract according to the above example was treated on fibroblasts. Here, it was confirmed that the senna leaf extract had no cytotoxicity up to 50 μg/mL.
본 발명에 따르면, 센나잎 추출물을 유효성분으로 함유한 블루라이트 차단용 조성물은 블루라이트 차단 효과가 우수하고 항산화효과가 우수하며, 독성도 없는 것이므로 천연 바이오 소재로 화장료나 식음료용, 의약용 소재로 널리 활용이 가능하다.According to the present invention, the blue light blocking composition containing senna leaf extract as an active ingredient has excellent blue light blocking effect, excellent antioxidant effect, and no toxicity, so it is used as a natural bio material for cosmetics, food and beverage, and medicine. It can be widely used.
또한, 뛰어난 천연 바이오 소재 조성물을 제공하기 때문에 생명바이오 식의약 산업상 매우 유용한 것이다.In addition, it is very useful in the biobio food and drug industry because it provides an excellent natural biomaterial composition.
Claims (13)
A composition for blocking blue light containing Senna alexandrina extract as an active ingredient.
The composition for blocking blue light according to claim 1, wherein the Senna alexandrina extract is extracted with a polar solvent from at least one selected from senna leaf, senna flower, senna fruit, senna stem, and senna root.
A cosmetic composition for blocking blue light containing senna extract as an active ingredient.
The cosmetic composition for blocking blue light according to claim 3, wherein the Senna alexandrina extract is extracted with a polar solvent from at least one selected from senna leaves, senna flowers, senna fruit, senna stems, and senna roots.
Cosmetic composition for the prevention and recovery of skin light damage caused by blue light, comprising senna extract as an active ingredient for blocking blue light.
A food and beverage composition for preventing and recovering skin light damage caused by blue light, comprising senna extract as an active ingredient for blocking blue light.
A pharmaceutical composition for preventing and treating skin diseases caused by blue light, containing senna extract as an active ingredient for blocking blue light.
The pharmaceutical composition for preventing and treating skin diseases according to claim 7, wherein the Senna alexandrina extract is extracted with a polar solvent from at least one selected from senna leaf, senna flower, senna fruit, senna stem, and senna root.
Pharmaceutical composition for the prevention and treatment of skin light damage caused by blue light, comprising senna extract as an active ingredient for blocking blue light.
Senna (Senna alexandrina) is a method for producing a composition for blocking blue light containing senna extract as an active ingredient, characterized in that the extraction using water, an alcohol having 1 to 6 carbon atoms or an aqueous alcohol solution.
The senna extract according to claim 10, further comprising the step of adding at least one selected from the group consisting of carbohydrate hydrolase, pectin hydrolase and cellulose hydrolysis urea after extraction of senna, and shaking and culturing. Method for producing a blue light blocking composition containing as an active ingredient.
The method of claim 11, further comprising the step of performing fractionation by adding an organic solvent for fractionation to the culture after shaking and culturing.
The method of claim 10, wherein the senna (Senna alexandrina) is at least one selected from senna leaves, senna flowers, senna fruit, senna stems, and senna roots.
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| KR20170025355A (en) * | 2015-08-28 | 2017-03-08 | 주식회사 엘지생활건강 | Composition for improving skin |
| KR101851623B1 (en) | 2017-07-25 | 2018-06-04 | 주식회사 아미코스메틱 | A cosmetic composition comprising spirulina extract for blue light interception |
| KR101918939B1 (en) | 2018-04-25 | 2018-11-15 | (주)더마랩 | Cosmetic composition containing fractions of dendropanax morbifera adventitious root extract |
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| KR102445710B1 (en) | 2022-09-23 |
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