KR20200140849A - A2a 수용체 길항제로서의 피라졸로트리아졸로피리미딘 유도체 - Google Patents
A2a 수용체 길항제로서의 피라졸로트리아졸로피리미딘 유도체 Download PDFInfo
- Publication number
- KR20200140849A KR20200140849A KR1020207031434A KR20207031434A KR20200140849A KR 20200140849 A KR20200140849 A KR 20200140849A KR 1020207031434 A KR1020207031434 A KR 1020207031434A KR 20207031434 A KR20207031434 A KR 20207031434A KR 20200140849 A KR20200140849 A KR 20200140849A
- Authority
- KR
- South Korea
- Prior art keywords
- mmol
- amino
- pyrazolo
- alkyl
- furan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/082140 | 2018-04-08 | ||
| CN2018082140 | 2018-04-08 | ||
| PCT/CN2019/081785 WO2019196803A1 (en) | 2018-04-08 | 2019-04-08 | Pyrazolotriazolopyrimidine derivatives as a2a receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200140849A true KR20200140849A (ko) | 2020-12-16 |
Family
ID=68163465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207031434A Ceased KR20200140849A (ko) | 2018-04-08 | 2019-04-08 | A2a 수용체 길항제로서의 피라졸로트리아졸로피리미딘 유도체 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11472811B2 (https=) |
| EP (1) | EP3774813A4 (https=) |
| JP (1) | JP2021520392A (https=) |
| KR (1) | KR20200140849A (https=) |
| CN (1) | CN112313234B (https=) |
| AU (1) | AU2019251148A1 (https=) |
| BR (1) | BR112020020078A2 (https=) |
| CA (1) | CA3095839A1 (https=) |
| EA (1) | EA202092036A1 (https=) |
| IL (1) | IL277744A (https=) |
| MX (1) | MX2020010618A (https=) |
| SG (1) | SG11202009706VA (https=) |
| TW (1) | TW202010500A (https=) |
| WO (1) | WO2019196803A1 (https=) |
| ZA (1) | ZA202005772B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3774813A4 (en) | 2018-04-08 | 2021-11-17 | BeiGene, Ltd. | PYRAZOLOTRIAZOLOPYRIMIDE DERIVATIVES AS A2A RECEPTOR ANTAGONIST |
| KR20230049580A (ko) * | 2020-03-26 | 2023-04-13 | 헵테얼즈 테라퓨틱스 리미티드 | 트리아졸론 화합물 |
| WO2021191376A1 (en) * | 2020-03-26 | 2021-09-30 | Astrazeneca Ab | Triazolone compounds |
| WO2022087146A1 (en) | 2020-10-22 | 2022-04-28 | Landos Biopharma, Inc. | Lancl ligands |
| CN113773327B (zh) * | 2021-09-13 | 2022-07-15 | 八叶草健康产业研究院(厦门)有限公司 | 一种吡唑并嘧啶并三唑环类化合物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60110219T2 (de) | 2000-05-26 | 2006-03-09 | Schering Corp. | Adenosin a2a rezeptor antagonisten |
| MXPA04003277A (es) | 2001-10-08 | 2004-07-23 | Hoffmann La Roche | Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico. |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| ATE461932T1 (de) | 2004-04-21 | 2010-04-15 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
| AU2011306358B2 (en) * | 2010-09-24 | 2014-08-14 | Impetis Biosciences Ltd. | Fused tricyclic compounds as adenosine receptor antagonist |
| WO2012135084A1 (en) | 2011-03-31 | 2012-10-04 | Merck Sharp & Dohme Corp. | METABOLITES OF 2-(FURAN-2-YL)-7-(2-(4-(4-(2-METHOXYETHOXY)PHENYL)PIPERAZIN-1-YL)ETHYL)-7H-PYRAZOLO[4,3-e][1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-5-AMINE AND THEIR UTILITY AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| WO2017136375A1 (en) | 2016-02-05 | 2017-08-10 | Concert Pharmaceuticals, Inc. | Deuterated tozadenant |
| EP3774813A4 (en) | 2018-04-08 | 2021-11-17 | BeiGene, Ltd. | PYRAZOLOTRIAZOLOPYRIMIDE DERIVATIVES AS A2A RECEPTOR ANTAGONIST |
| CN110742893B (zh) | 2018-07-23 | 2024-04-05 | 百济神州(北京)生物科技有限公司 | A2a受体拮抗剂治疗癌症的方法 |
-
2019
- 2019-04-08 EP EP19785064.7A patent/EP3774813A4/en not_active Withdrawn
- 2019-04-08 US US16/982,681 patent/US11472811B2/en active Active
- 2019-04-08 AU AU2019251148A patent/AU2019251148A1/en not_active Abandoned
- 2019-04-08 CN CN201980024422.3A patent/CN112313234B/zh not_active Expired - Fee Related
- 2019-04-08 BR BR112020020078-6A patent/BR112020020078A2/pt not_active IP Right Cessation
- 2019-04-08 EA EA202092036A patent/EA202092036A1/ru unknown
- 2019-04-08 MX MX2020010618A patent/MX2020010618A/es unknown
- 2019-04-08 WO PCT/CN2019/081785 patent/WO2019196803A1/en not_active Ceased
- 2019-04-08 TW TW108112189A patent/TW202010500A/zh unknown
- 2019-04-08 CA CA3095839A patent/CA3095839A1/en active Pending
- 2019-04-08 JP JP2020554834A patent/JP2021520392A/ja not_active Withdrawn
- 2019-04-08 KR KR1020207031434A patent/KR20200140849A/ko not_active Ceased
- 2019-04-08 SG SG11202009706VA patent/SG11202009706VA/en unknown
-
2020
- 2020-09-17 ZA ZA2020/05772A patent/ZA202005772B/en unknown
- 2020-10-01 IL IL277744A patent/IL277744A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202009706VA (en) | 2020-10-29 |
| TW202010500A (zh) | 2020-03-16 |
| MX2020010618A (es) | 2020-11-12 |
| US20210198267A1 (en) | 2021-07-01 |
| EA202092036A1 (ru) | 2021-01-28 |
| AU2019251148A1 (en) | 2020-10-22 |
| EP3774813A1 (en) | 2021-02-17 |
| US11472811B2 (en) | 2022-10-18 |
| CN112313234A (zh) | 2021-02-02 |
| WO2019196803A1 (en) | 2019-10-17 |
| BR112020020078A2 (pt) | 2021-01-05 |
| JP2021520392A (ja) | 2021-08-19 |
| CA3095839A1 (en) | 2019-10-17 |
| ZA202005772B (en) | 2022-01-26 |
| EP3774813A4 (en) | 2021-11-17 |
| CN112313234B (zh) | 2022-04-29 |
| IL277744A (en) | 2020-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
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| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
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| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
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| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
St.27 status event code: N-2-6-B10-B15-exm-PE0601 |
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| R18 | Changes to party contact information recorded |
Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
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| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |