KR20200126239A - Effervescent tablet comprising curcumin and red ginseng and process for preparing the same - Google Patents

Abstract

The present invention relates to a curcumin red ginseng effervescent tablet and a method for manufacturing the same. More specifically, the present invention relates to: a red ginseng effervescent tablet which contains red ginseng powder and extracts of Curcuma longa and Glycyrrhiza uralensis in balance with red ginseng, and is obtained by manufacturing the same in a fast disintegrating tablet, thereby rapidly exhibiting antioxidant functionality and fatigue recovery functionality; and a method for manufacturing the curcumin red ginseng effervescent tablet. The red ginseng effervescent tablet according to the present invention allows consumers to conveniently consume red ginseng products with improved functionality and palatability, and since active components containing ingested red ginseng are rapidly disintegrated and absorbed, bioavailability is high and sodium content is low, thereby providing a desirable effect to consumers who require the same.

Description

Curcumin red ginseng effervescent tablet and its manufacturing method {Effervescent tablet comprising curcumin and red ginseng and process for preparing the same}

The present invention relates to a curcumin red ginseng effervescent tablet and a method of manufacturing the same, and more particularly, it contains a red ginseng powder and turmeric and licorice extract in balance with red ginseng, and is prepared as a fast disintegrating tablet, so that the function of antioxidant and fatigue recovery It relates to a red ginseng effervescent tablet and a method for producing the same.

Various types of formulations for supplying the active ingredient to the body have been conveniently and usefully used for a long time.

In general, a beverage having a liquid formulation needs a container for storing it, and when the amount of liquid is large, the volume of the container increases or the quantity of the container increases, making it difficult to store and carry. In addition, for liquid products, packaging containers such as cans, PET bottles, and glass bottles are essential, and to improve the preservation of the product, it is necessary to undergo a sterilization process during the manufacturing process or add preservatives such as sodium benzoate, resulting in high manufacturing costs. .

Effervescent tablets are tablets in the form of tablets, so they are easy to store and have a small volume, so they are easy to carry. The manufacturing process is relatively simple and the packaging cost of the product is relatively inexpensive.

These effervescent tablets are widely used in food and pharmaceutical fields because they can be easily ingested anywhere with drinking water.

The ideal effervescent tablet needs physical properties suitable for smooth production, transport, packaging, storage, etc., along with the properties that disintegrate quickly and smoothly in the oral cavity. Such physical properties include high hardness and low friability. However, unfortunately, if the disintegration is fast, the physical properties of the tablet are bad, and if the physical properties are good, the disintegration worsens. Most of the effervescent tablets on the market find a point where there is an appropriate balance or compromise between the two, or focus on one side, but the insufficient part is returned to the consumer's share and written in the precautions, or supplemented by other methods such as special packaging. Most of them have been.

The manufacturing technology of effervescent tablets is a method using freeze-drying, a method similar to that of cotton candy, a method of containing an appropriate amount of a foaming agent in a tablet, a method of using a large amount of disintegrant, a high-solubility saccharide and high stability. A method of using an appropriate combination of formed saccharides, a method of improving physical properties by treating tablets obtained after low pressure tableting with humidification or heating, and a method of improving the tableting machine and spraying a lubricant into the mold in which the tablets are tableted to contain almost no lubricant. A method of producing a mixture without difficulty in tabletting is known.

However, many of the above effervescent tablet manufacturing techniques require special equipment or expensive equipment, or general pharmaceutical equipment cannot be used as it is, and thus special improvement is required. This may cause an increase in manufacturing cost, and restrictions may be imposed on various applications. In addition, even if a specific temperature and humidity condition is required after tableting or tableting, the tablet may be exposed to unnecessary equipment investment and harsh conditions, which may limit its application.

On the other hand, red ginseng (red ginseng) is steamed and dried ginseng (Panax ginseng CA MEYER) belonging to the Araliaceae family. It has a sweet temper, bitter taste, flat in nature, and is known as bi and lungs. It is a representative medicine in oriental medicine. The main efficacy is Daebowongi (大補元氣), Napgipyeongcheon (納氣平喘), Saengjinjigal (生津止渴). It has sedation and excitement for the central nervous system. It has an effect of preventing hypertension or arteriosclerosis by acting, so it has a strong cardiac action, an antioxidant action, an anti-fatigue action, an anti-radiation action, and a hypoglycemic action. The main ingredients include saponin (ginsenosides), panaxynol, beta-elemene, and maltol. Red ginseng extract has been used to treat anemia, diabetes, insomnia, gastritis, blood pressure abnormalities, indigestion, overwork, and fatigue, and is reported to contain various triterpene glycosides called saponins.

The demand for red ginseng products is wide and there is a demand for products that satisfy requirements such as functionality, convenience, and fast-acting due to the demands of increasingly high-end consumers.

Korean Patent Registration No. 10-0638833 Republic of Korea Patent Publication No. 10-2012-0047607 Republic of Korea Patent Publication No. 10-2006-0119647

The present inventor solves the problems associated with the prior art as described above, and develops a product that satisfies the requirements such as functionality, convenience and fast disintegration characteristics while being inexpensive, while allowing consumers to more easily access red ginseng products. As a result of careful research, as will be described later, red ginseng effervescent tablets made with turmeric extract and vitamin C, which are the main components of red ginseng and licorice, and curcumin, as active ingredients, have antioxidant and fatigue-relieving functions, while handling and convenience are improved. It was found that the above requirements could be satisfied by showing fast disintegration, and the present invention was completed.

Accordingly, an object of the present invention is to produce red ginseng effervescent tablets that are prepared using red ginseng, turmeric and licorice extracts and vitamin C as active ingredients, and have antioxidant and fatigue recovery functions, while improving handling and convenience and exhibiting fast disintegration properties, and their preparation It is in providing a way.

The object of the present invention is to include red ginseng powder 20-40 wt%, vitamin C powder 7-12 wt%, turmeric extract powder 3-10 wt%, licorice extract powder 3-10 wt%, and fast disintegrating composition 45-55 wt% It can be achieved by the characterized red ginseng effervescent tablet and its manufacturing method.

The red ginseng effervescent tablet according to the present invention allows consumers to conveniently consume red ginseng products with improved functionality and palatability, and active ingredients including ingested red ginseng are rapidly disintegrated and absorbed, resulting in high bioavailability and low sodium content. It can provide a desirable effect to the consumer.

1 is a manufacturing process chart of red ginseng effervescent tablet according to an embodiment of the present invention.
2 is a test report of sodium content of red ginseng effervescent tablet and vitamin C effervescent tablet according to an embodiment of the present invention.
3 is a graph showing the antioxidant effect of red ginseng effervescent tablets according to the present invention.

The present invention, in one aspect, comprising 20 to 40 wt% red ginseng powder, 7 to 12 wt% vitamin C powder, 3 to 10 wt% turmeric extract powder, 3 to 10 wt% licorice extract powder, 45 to 55 wt% of a composition for fast disintegration It provides a red ginseng effervescent tablet, characterized in that.

The present invention, in a further aspect,

a) pre-treatment of red ginseng, turmeric, and licorice, followed by extraction to prepare raw material components in powder form;

b) mixing red ginseng powder 20-40 wt%, vitamin C powder 7-12 wt%, turmeric extract powder 3-10 wt%, and licorice extract powder 3-10 wt%;

c) agglomerating after adding 45 to 55 wt% of a fast disintegrating composition to the mixture obtained in the above step;

d) forming the agglomerated mixture in a tablet form by using a tablet press;

e) drying the tableted tablets; And

It provides a method for producing red ginseng effervescent tablets comprising; f) packaging the dried tablets in a predetermined unit.

Hereinafter, preferred embodiments of the red ginseng effervescent tablet and a method of manufacturing the same according to the present invention will be described in detail with reference to the accompanying drawings.

Terms and words used in the present specification and claims are not limited to the usual or dictionary meanings, and the inventor is based on the principle that the concept of terms can be appropriately defined in order to explain his or her invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention. Therefore, it is understood that the embodiments described in this specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and there may be various equivalents and modifications that can replace them at the time of the present application. shall.

The red ginseng effervescent tablet according to the present invention includes red ginseng powder, vitamin C, turmeric extract and licorice extract as active ingredients.

Red ginseng is the main ingredient of the active ingredient that shows fatigue recovery and antioxidant effects, and in cooperation with vitamin C, turmeric extract, licorice extract and foaming composition, it exerts the desired antioxidant effect and the function of relieving fatigue.

Vitamin C strengthens immunity and alleviates symptoms such as weakness, anemia, high blood pressure, and inflammation, and can be easily taken in everyday life, regardless of location.

Turmeric ( Curcuma longa ) is a perennial plant belonging to the ginger family, also called turmeric. Recently, it is a plant cultivated in the southern regions of Korea and is used as a raw material for curry. In ancient books such as'Boncho Gangmok'and'Donguibogam', turmeric is known for its edema, gastric juice secretion, diuretic, detoxification, anticancer, anti-inflammatory, and antioxidant properties. Curcumin, an indicator component of turmeric, is a diketone body and has strong antioxidant and cancer cell killing effects, and p-tolylmethylcarbinol is known as a natural compound with bidam action.

Licorice refers to a perennial herbaceous plant belonging to the genus Glycyrrhiza. It is also called a plant. The outer shell of the licorice is reddish brown or dark brown, has vertical wrinkles, sometimes has a pedicel, sprout and scale leaves, has a peculiar smell and tastes sweet, Russia (Siberia), Iran, Afghanistan, Pakistan, China (sensitivity, Xinjiang), refers to a plant that grows in Mongolia and grows or grows in Korea. In oriental medicine, it has been used to harmonize the toxicity of all medicines to make the medicinal effect appear well, to control the fever and morale of the ledger, to communicate well with all blood veins, and to strengthen muscles and bones. Licorice used in the present invention may be obtained from nature or purchased commercially, but is not limited thereto. Licorice, an active ingredient in the present invention, functions to gently neutralize the taste of turmeric and red ginseng.

The present invention has a technical feature to provide a foaming agent that synergistically exhibits fatigue recovery and antioxidant functions by an appropriate combination ratio of these main ingredients, and the appropriate mixing ratio of these ingredients is 20 to 40 wt% of red ginseng powder and 7 to 12 wt of vitamin C powder. %, turmeric extract powder 3-10wt%, licorice extract powder 3-10wt%, and it is preferable to include 45-55wt% composition for fast disintegration. If the composition of the active ingredient is out of the set range, there is a fear that the taste and aroma cannot be balanced, and the antioxidant function and the function of fatigue recovery may be deteriorated.

In particular, if the content of the main component is less than 45% by weight with respect to the fast disintegrating composition, there may be a problem in content uniformity, and if it exceeds 55% by weight, there is a concern that physical properties such as hardness and friability of the effervescent tablet may deteriorate.

The composition for fast disintegration contains 25 to 35 parts by weight of sodium tartrate, 15 to 25 parts by weight of mannitol, 15 to 25 parts by weight of sodium hydrogen carbonate, white sugar, chitosan and sodium alginate in a weight ratio of 1:0.5 to 1:0.2 to 0.5. It is preferable to include 10 to 20 parts by weight of the binder and 3 to 10 parts by weight of magnesium stearate.

The sodium stannate functions as a stabilizer, and is preferably used in an amount of 25 to 35 parts by weight based on the weight of the fast disintegrating composition. Outside the above content range, there is a concern that the stability and buffering properties of the composition may be deteriorated.

As a sugar alcohol, mannitol is a component that provides the hardness, compressibility and flow properties of a fast disintegrating tablet. It is well soluble in water, is chemically stable, is non-hygroscopic, and exerts a good taste when disintegrating in the oral cavity. The mannitol is preferably used in an amount of 15 to 25 parts by weight based on the weight of the fast disintegrating composition, and if the content of mannitol is out of the range set above, the hardness may be low or the disintegration time may be delayed.

The sodium bicarbonate may be appropriate to use in an amount of 15 to 25 parts by weight based on the weight of the composition for fast disintegration and performs a function of promoting disintegration of the formulation. Beyond this, if it is included in less than 15% by weight, foaming performance may be deteriorated, and if it is included in more than 25% by weight, there is a concern that the efficiency as a formulation may decrease due to a decrease in the content of other ingredients.

The binder may be preferably used by mixing white sugar, chitosan, and sodium alginate in a weight ratio of 1:0.5 to 1:0.2 to 0.5 with a solvent such as ethanol of the same weight. This binder component was selected as a component that induces rapid disintegration due to its high hardness and excellent water solubility. Therefore, when the content of the binder is low, there may be a problem in that the hardness of the tablet is lowered, and when it exceeds a set range, there may be a problem that the disintegration time is delayed.

The magnesium stearate is a component used as a lubricant and prevents lumping of powder, allows the tablet to be discharged well from the tableting die, and hardens the tablet to lower the friability of the tablet. The lubricant may preferably contain 3 to 7 parts by weight based on the weight of the composition for fast disintegration. Outside of this range, there is a concern that problems such as a decrease in the hardness of the tablet, a delay in disintegration time, and a decrease in dissolution rate may occur.

According to a more preferred embodiment of the present invention, the composition for fast disintegration may further contain excipients or additional ingredients commonly used in the art for the purpose of further improving taste, appearance, or storage stability of tablets.

The specific type and content of the excipients are well known in the art to which this invention belongs, and can be modified in various categories.

Such a component may include a suspending agent that promotes foaming, for example, one selected from the group consisting of sorbitol, xylitol, dextyrin, maltodextrin, lactose, starch, microcrystalline cellulose, crospovidone and dicalcium phosphate, or A mixture of two or more may be used. The suspending agent may be preferably included in an amount of 1 to 3% by weight based on the weight of the composition for fast disintegration.

In addition, a sweetening agent may be further included, and aspartame, sugar, acesulfame potassium, stevioside, glucose, fructose, sodium saccharin and sucralose may be preferably used as the sweetener.

Likewise, you can include more spices, which include pineapple, apple, orange, lemon, grape, cherry, peach, apricot, strawberry, mango, lime, melon, plum, and mulberry. Incense, bokbunjahyang, ginseng flavor, red ginseng flavor, jujube flavor, ginger flavor or citron flavor can be preferably used.

Hereinafter, a method of manufacturing red ginseng effervescent tablets according to the present invention will be described. 1 is a manufacturing process chart of red ginseng effervescent tablet according to an embodiment of the present invention.

As shown in Fig. 1, the red ginseng effervescent tablet according to the present invention includes a raw material manufacturing step, a mixing step, a tableting step, a drying step, and a packaging step. Hereinafter, each individual step will be described in detail.

a) raw material manufacturing steps

Red ginseng can be prepared in a conventional manner as is well known. For example, ginseng is steamed at 80 to 100°C for 3 to 6 hours, and then cooled to 20 to 25°C is repeated 3 to 5 times. I can. In addition, red ginseng may be dried and powdered or extracted and concentrated to a high concentration, and then powder or granules may be used.

Turmeric and licorice can be prepared through pretreatment and then extraction. It is preferable to use dried roots for turmeric and dry stems for licorice.

First, in the pretreatment step, it may be desirable to treat vegetable materials including turmeric and licorice by a series of steps including a1) washing step, a2) drying step, a3) mincing step and a4) mixing step.

First, in the a1) washing step, turmeric and licorice are washed with clean water.

In the washing, purified water is sprayed to remove foreign substances such as dust, soil, and insects from the vegetable material, so that the quality of the final manufactured product may be prevented from deteriorating due to bacteria inhabiting the foreign substance in the subsequent process.

Then, in the drying step a2), the washed vegetable material is naturally dried or dried using a dryer.

In the case of natural drying, for example, in a well-ventilated room, spread out a plant material to a thickness of 1 to 2 cm, place it on a shelf or a net, and turn it intermittently at room temperature for 12 to 30 hours to evaporate moisture evenly.

Meanwhile, the drying time when drying under direct sunlight is preferably 0.2 to 1 hour, preferably 0.5 to 1 hour, depending on the amount of sunlight.

In addition, in the case of using a dryer, it may be desirable to dry it at a temperature of 50° C. or less for around 48 hours. In the drying step, it may be desirable to dry so that the moisture content of the material is 50 to 65% (w/w).

Subsequently, in the step a3), the slicing step is mainly performed using a slicing machine, but as long as the stem or root is sliced to an appropriate size, it is not limited thereto, and the slicing size is preferably about 2 to 5 cm in length.

Then, in the mixing step a4), the chopped vegetable material is mixed in an appropriate ratio and subsequently processed.

Then, in the extraction step, it may be preferable to extract the active ingredient through b1) extraction, b2) filtration, b3) concentration, b4) drying, and b5) pulverization.

b1) In the extraction step, add turmeric and licorice to the extractor, add 5 to 25 multiples of water or organic solvent based on the weight, and brew for 6 to 72 hours at a medium temperature of 0.5 to 0.6 atmospheres and 70 to 95 °C. It may be desirable to extract.

The organic solvent is methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1 ,3-butylene glycol, propylene glycol, or a mixed solvent thereof may be used.

There is a concern that the content of the active ingredient may decrease when the medium temperature extraction conditions are exceeded.

Then, in the filtration step b2), solid foreign substances and particles may be filtered using, for example, a filter membrane, paper filter paper, nonwoven fabric or cotton, or filtered using an ultrafiltration method, a cryofiltration method, a centrifugation method, or the like. Further, filtration may be performed by first filtering using gauze and then second filtering using Whatman paper.

Subsequently, in the concentration step b3), the obtained filtrate is concentrated so that the brix° of solid content is 40 or more for 4 to 8 hours under reduced pressure of -0.08 to -0.09 MPa at a temperature of 50 to 65°C. The yield may be best when concentrated under reduced pressure of -0.08 to -0.09 MPa using a vacuum concentrator.

Then, in the drying step b4), it is preferable to dry the obtained concentrate at a temperature of 55 to 65° C. under vacuum for 24 to 48 hours at a low temperature.

b5) In the pulverization step, as a process of pulverizing the concentrated extract of turmeric and licorice into 80 to 120 mesh, it may be preferable to pulverize to a particle size of 80 mesh or less using a pulverizer, a hammer mill, or a pin mill.

b) mixing step

In the mixing step, red ginseng, turmeric extract, licorice extract and vitamin C in powder form prepared as described above are first homogeneously mixed.

c) agglomeration step

Subsequently, a composition for fast disintegration containing a liquid binder is added to the mixture in the form of a powder within the set range to cause agglomeration.

The mixing and agglomeration step may be performed using a mixer, a mixer, a high-speed mixer, or a manual method.

d) tableting step

Effervescent tablets according to the present invention can be prepared using a tablet press or molding machine generally used in pharmaceutical processes.

The compression pressure used to compress the mixture into tablets is generally about 150 MPa or less (e.g., 1 Pa to 150 MPa), preferably about 35 MPa or less, more preferably about 10 MPa or less. It may be desirable to perform.

e) drying step

A mild condition for drying the tablet may be a condition of room temperature without humidity, for example, a temperature of 20 to 30°C and a humidity condition of 40%RH or less. For faster and more reliable drying, a low temperature convection oven of 20 to 50°C may be used, and a method of supplying dry air, a method of using a dehumidifier, a method of using a dehumidifying agent, etc. may be used.

For example, the drying operation may be performed in a manner such as a convection oven, a vacuum oven, a fluid bed dryer, a dryer, and natural drying at room temperature.

f) packaging steps

The tablets dried in the above step are packed and packaged according to the size of a certain unit. Subsequently, according to standards and specifications, after inspecting properties, foreign substances, moisture, number of bacteria, E. coli, etc., only suitable products are shipped.

The red ginseng effervescent tablet according to the present invention has excellent stability, as can be seen from the results of Examples and Test Examples described later, and can be used as a functional health food for the purpose of antioxidant efficacy, diet or fatigue recovery. In addition, it can be absorbed quickly in the body to show immediate effect.

Sodium is a kind of mineral that regulates various physiological functions in the body, such as water balance and acid-alkali balance. Minerals are not synthesized in the body, so they must be consumed as food. Minerals can be obtained from various foods such as vegetables, fruits, meat, and fish, and sodium is mainly consumed in the form of sodium chloride contained in salt. Sodium plays a role in delivering stimulation to the body, and at this time, the balance with potassium, which is also a kind of mineral, is important. Sodium, along with potassium, maintains the balance of acids and alkalis in our body and regulates the volume of plasma to maintain normal blood pressure. Insufficient sodium can lead to loss of appetite, indigestion, coma, kidney disease, hypotension, and decreased liver function, and lack of potassium can lead to diarrhea, vomiting, uric acidosis, and Cushing's disease.

On the other hand, even a small increase in sodium and potassium concentrations in plasma has a great effect on blood pressure and cardiovascular exercise. When sodium intake is excessive, the volume of blood increases due to the water balance control function, which greatly affects arterial blood pressure, causing high blood pressure or straining the kidneys. When sodium is excessive in the body, thirst, fatigue, sleep disturbances, swelling, and high blood pressure occur, and in severe cases, seizures can occur. In addition, studies have shown that excessive intake of sodium induces nervous anxiety, emotional anxiety, stress, and suicidal thoughts, and is also associated with gastric cancer, gastric ulcers, and osteoporosis.

The World Health Organization and the U.S. National Institutes of Health propose a recommended daily intake of 5g to 6g of salt for adults, and according to this standard, sodium is equivalent to 2000mg and 2400mg.

Effervescent tablets distributed in the market have a problem in that an excessive amount of sodium component remains when disintegrated by water, but the red ginseng effervescent tablet according to the present invention has less sodium content and does not exhibit adverse side effects to the human body.

(Example)

Hereinafter, the content of the present invention will be described in detail through examples and test examples. However, these are for describing the present invention in more detail, and the scope of the present invention is not limited thereto.

Preparation Example 1: Preparation of red ginseng extract

After steaming 10 Kg of ginseng for 3 hours at 95℃, the process of cooling to 20℃ was repeated three times to prepare red ginseng, then shredded and dried by turning it intermittently for 24 hours at room temperature. Was prepared.

Preparation Example 2: Preparation of turmeric and licorice extract powder

After washing 5 kg of turmeric root and 5 kg of licorice stems with clean water, they were spread evenly in a well-ventilated room, placed on a shelf, and dried while turning intermittently for 24 hours at room temperature. Then, cut the stem and root into approximately 2~3cm size, pretreat, put it in an extractor, add 20 times water or an organic solvent based on the weight, and then brew it at 0.5~0.6 atm and a temperature of 85℃ for 48 hours. After extracting it, filtering it with a nonwoven fabric, collecting the filtrate, and concentrating the solid for 4 hours under reduced pressure of -0.08 to -0.09 MPa at a temperature of 65°C, and drying the concentrate at a temperature of 55°C under vacuum for 24 hours at 80 It was pulverized into a mesh size to obtain an extract powder.

The yield of the extract showed some differences depending on the solvent. In the case of purified water, the yield of turmeric was 28.23% and the licorice was 23.65%, and when the solvent was used as alcohol, the yield of turmeric was 31.15%, and the yield of licorice was 26.65%. .

Examples 1 to 6 and Comparative Example 1: Preparation of red ginseng effervescent tablet

After mixing the red ginseng, licorice, and turmeric extract powder prepared in Preparation Examples 1 and 2 with commercially available vitamin C, the composition for fast disintegration as shown in Table 1 was added, and then agglomerated under high-speed rotation, and then a tableting machine After tableting using, a red ginseng effervescent tablet having a diameter of 25 mm, a thickness of 6 mm, and a weight of 4.0 g was prepared by drying at a temperature of 25° C. and a humidity condition of 40%RH or less. In the example of the present invention, the same weight of ethanol was mixed with a mixture of sucrose, chitosan, and sodium alginate in a weight ratio of 1:0.5:0.2, and microcrystalline cellulose was used in Comparative Example 1.

Ingredient content (g) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Red ginseng powder 200 250 300 300 350 400 500 Vitamin C 120 100 90 80 70 70 50 Turmeric extract powder 100 70 70 30 50 30 - Licorice extract powder 100 30 50 70 50 50 - Composition for fast disintegration 480 550 490 550 480 450 450 Sodium stannate Part 25 Part 35 Part 35 Part 35 Part 35 Part 35 Part 25 Mannitol Part 25 Part 15 Part 25 Part 25 Part 15 Part 17 Part 25 Sodium hydrogen carbonate Part 25 Part 24 Part 15 Part 17 Part 25 Part 25 Part 20 Binder Part 12 Part 20 Part 20 Part 10 Part 12 Part 20 - Magnesium stearate Part 10 Part 5 Part 4 Part 10 Part 10 Part 3 Part 10 Microcrystalline cellulose Part 3 chapter 1 chapter 1 Part 3 Part 3 Part 0 Part 20

Test Example 1: Test of physical properties of tablets

The tablets prepared in the above examples were tested for physical properties according to the test method shown below, and the results are shown in Table 2 below.

[Hardness measurement]

The hardness of the tablet was measured using a hardness tester 8M (Hardness tester 8M, Dr. Schleuniger, Switzerland), and at least six samples were measured and the average value was recorded.

[Measurement of wear and tear]

It was tested according to the method of measuring tablet friability described in Tablet Friability of the General chapters for general testing and analysis of US Pharmacopoeia (USP) 25.

[Underwater disintegration test]

It was tested according to the disintegration test method tablet section of the general test methods of the 8th edition of the Korean Pharmacopoeia. Water was used as the test solution, and the test was performed using 6 samples at 37°C, and the average value was recorded.

[Intraoral disintegration test]

In the case of a fast disintegrating tablet, a disintegration test of the fast disintegrating tablet in the oral cavity was performed on the volunteer. After randomly selecting volunteers to rinse their mouths with water, the disintegration time was measured by placing tablets on the volunteers' tongues and immediately operating a stopwatch. Volunteers were allowed to use their tongue to move the fast-disintegrating tablet to the ceiling of the mouth, and to roll the tablet smoothly without biting it or roll it side to side. As soon as the tablet disintegrated and became swallowable with saliva, the stopwatch was stopped and the time was recorded.

[Dry Loss]

In the case of loss on drying of powder or granules, about 2g of a sample was taken and spread evenly on an aluminum plate, and measured at 105℃ for several to tens of minutes using a Sartorius MA100 LOD meter. Allow the test to end.

In the case of loss on drying of tablets, a sample corresponding to about 2 g was taken and placed in an aluminum dish and measured in the same manner as for the loss on drying of powder or granules.

[Content uniformity]

It was tested according to the content uniformity test method in the Korean Pharmacopoeia formulation uniformity test method. Take 1 tablet of the drug to be tested, put it in 5 ml of the mobile phase, shake and mix to completely disintegrate, and then this solution was centrifuged and the supernatant was filtered through a membrane filter having a pore diameter of 0.45 μm. About 2 ml of the first filtrate was discarded, and the next filtrate was taken as the sample solution. 10 µl of the sample solution was tested according to the liquid chromatography method of the Korean Pharmacopoeia, but was detected at a wavelength of 254 nm using an appropriate column and flow rate. The preparation method of the mobile phase was as follows: 0.05 mol/l potassium dihydrogen phosphate solution was added with diluted phosphoric acid to adjust the pH to 4.0, and to 800 ml of this solution were added 100 ml of methanol and 100 ml of tetrahydrofuran.

Test Items Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Hardness(Kp) 4.2 4.2 4.1 4.3 4.3 4.2 2.7 Tablet friability (%) 0.3 0.3 0.3 0.3 0.3 0.3 0.7 Disintegration time in water (sec) 20.1 20.3 20.3 20.2 20.1 20.3 35.2 Oral disintegration time (seconds) 17 18 17 16 15 18 32.2 Loss on drying (%) 0.82 0.85 0.86 0.83 0.81 0.86 1.25 Content uniformity (%) 3.3 3.2 3.2 3.2 3.1 3.1 3.6

As can be seen from the above test results, the product of Example of the present invention satisfies all the standard requirements, while the product of Comparative Example 1 only satisfies the minimum standard.

Test Example 2: Measurement of sodium content

The effervescent tablet according to the embodiment of the present invention was foamed in water at 60° C. and the sodium content was requested to an external testing laboratory to analyze the sodium content. A commercial product (vitamin C from G Pharmaceutical) was used as a comparative product. The results are shown in Table 3 and Fig. 2. 2 is a test report of sodium content of red ginseng effervescent tablet and vitamin C effervescent tablet according to an embodiment of the present invention.

division Example 3 Comparative Example 1 Sodium content 50.83mg 350mg

As shown in Table 3, it can be seen that the effervescent tablet according to the embodiment of the present invention has an 85% decrease in sodium content. In addition, 80.910g of sodium was detected in 1000g of effervescent tablets according to the embodiment of the present invention as shown in the test report shown in FIG. 2.

Test Example 3: DPPH antioxidant effect measurement

DPPH free radical scavenging experiments were performed on the samples of Examples 1 to 6 and Comparative Example 1. DPPH (1,1-diphenyl-2-picrylhydrazyl) is itself a very stable free radical. It measures a dark purple compound that exhibits specific light absorption at 517 nm. It is an antioxidant with radical scavenging activity. Antioxidant activity can be easily measured due to quantitative decolorization by. Such radical scavenging activity is widely used in antioxidant screening because it shows a correlation with antioxidant activity including lipid peroxidation inhibitory activity. Antioxidant activity measurement (Electron donating abilities, EDA) of the sample was measured by modifying the Blois method. The sample extract of a certain concentration and DPPH solution (5mg/100 mL methanol) were mixed in the same amount, reacted at room temperature for 20 minutes, and then absorbance was measured at 517 nm. The electron donating effect was expressed by the rate of decrease in absorbance between the addition and no addition of the sample solution. The resulting free radical scavenging ability was calculated by the following equation.

Free radical scavenging activity (%)= {1-(B/A)}×100

In the formula, A: absorbance of a control well without a sample treatment, B: absorbance of an experimental well treated with a sample. The results are shown in Table 4 and FIG. 3.

Ex1 Ex2 Ex3 Ex4 Ex5 Ex6 Comp. Ex1 DPPH free radical-scavening activity (%)
86.32
85.72
85.52
84.36
85.24
84.65
25.51

Through the above results, it was confirmed that the samples of Examples 1 to 6 generally showed superior DPPH-free radical scavenging ability compared to those of the Comparative Example.

Test Example 4: Sensory evaluation

A sensory test was performed on the red ginseng effervescent tablets of Examples 1 to 6 and Comparative Example 1. The panel selected 30 trained inspectors, evaluated the appearance, aroma, taste, and overall acceptance according to the following 5-point scale method, and averaged each value, and the results are shown in Table 5 below. As for the evaluation criteria, the very good degree was set to 5, the slightly good degree was set to 4, the moderate degree was set to 3, the poor degree was set to 2, and the very poor degree was set to 1.

Evaluation item Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 flavor 4.3±0.4 4.4±0.3 4.4±0.3 4.5±0.6 4.5±0.5 4.4±0.2 3.1±0.3 incense 4.3±0.2 4.5±0.3 4.5±0.4 4.4±0.3 4.4±0.3 4.4±0.5 2.5±0.3 Refreshing 4.4±0.2 4.5±0.3 4.3±0.3 4.3±0.3 4.3±0.6 4.3±0.3 3.1±0.5 Comprehensive evaluation 4.5±0.4 4.4±0.1 4.4±0.3 4.3±0.4 4.4±0.2 4.4±0.2 2.4±0.4

As a result of the sensory test, the products of the examples were significantly different from those of the comparative examples in terms of taste, aroma, and freshness, and were generally excellent.

Although the preferred embodiments of the present invention have been described as above, those skilled in the art will understand that the present invention can be variously modified and changed within the scope not departing from the spirit and scope of the present invention described in the claims below. I will be able to.

Claims (4)

Red ginseng effervescent tablet comprising 20 to 40 wt% of red ginseng powder, 7 to 12 wt% of vitamin C powder, 3 to 10 wt% of turmeric extract powder, 3 to 10 wt% of licorice extract powder, and 45 to 55 wt% of a composition for fast disintegration. The method according to claim 1,
The composition for fast disintegration contains 25 to 35 parts by weight of sodium tartrate, 15 to 25 parts by weight of mannitol, 15 to 25 parts by weight of sodium hydrogen carbonate, white sugar, chitosan and sodium alginate in a weight ratio of 1:0.5 to 1:0.2 to 0.5. Red ginseng effervescent tablet comprising 10 to 20 parts by weight of a binder and 3 to 10 parts by weight of magnesium stearate. a) pre-treatment of red ginseng, turmeric, and licorice, followed by extraction to prepare raw material components in powder form;
b) mixing red ginseng powder 20-40 wt%, vitamin C powder 7-12 wt%, turmeric extract powder 3-10 wt%, and licorice extract powder 3-10 wt%;
c) agglomerating after adding 45 to 55 wt% of a fast disintegrating composition to the mixture obtained in the above step;
d) forming the agglomerated mixture in a tablet form by using a tablet press;
e) drying the tableted tablets; And
f) packing the dried tablets in a predetermined unit; a method for producing red ginseng effervescent tablets comprising: The method of claim 4,
The composition for fast disintegration contains 25 to 35 parts by weight of sodium tartrate, 15 to 25 parts by weight of mannitol, 15 to 25 parts by weight of sodium hydrogen carbonate, white sugar, chitosan and sodium alginate in a weight ratio of 1:0.5 to 1:0.2 to 0.5. A method for producing red ginseng effervescent tablets comprising 10 to 20 parts by weight of a binder and 3 to 10 parts by weight of magnesium stearate.

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