KR102290553B1 - Effervescent tablet comprising curcumin and red ginseng and process for preparing the same - Google Patents

Abstract

The present invention relates to an effervescent tablet of curcumin red ginseng and a manufacturing method thereof, and more particularly, to red ginseng powder and turmeric and licorice extract balanced with red ginseng, and prepared as a fast-dissolving tablet, thereby providing rapid antioxidant functionality and fatigue recovery functionality. It relates to a red ginseng effervescent tablet and a method for producing the same. The red ginseng effervescent tablet according to the present invention allows consumers to conveniently consume red ginseng products with improved functionality and palatability, and the active ingredients including the ingested red ginseng are rapidly disintegrated and absorbed, resulting in high bioavailability and low sodium content. It can provide desirable effects to consumers who

Description

Effervescent tablet comprising curcumin and red ginseng and process for preparing the same

The present invention relates to an effervescent tablet of curcumin red ginseng and a manufacturing method thereof, and more particularly, to red ginseng powder and turmeric and licorice extract balanced with red ginseng, and prepared as a fast-dissolving tablet, thereby providing rapid antioxidant functionality and fatigue recovery functionality. It relates to a red ginseng effervescent tablet and a method for producing the same.

Various types of formulations for supplying active ingredients into the body have been conveniently and usefully used for a long time.

In general, a beverage having a liquid formulation requires a container for storing it, and when the amount of liquid is large, the volume of the container increases or the quantity of the container increases, so storage and portability are not easy. And liquid formulations require packaging containers such as cans, PET bottles, and glass bottles, and in order to improve the preservation of the product, a sterilization process or the addition of a preservative such as sodium benzoate is required during the manufacturing process, so manufacturing costs are high. .

Effervescent tablets are tablets in the form of tablets, so they are easy to store, have the advantages of being small and portable, and the manufacturing process is relatively simple and the packaging cost of the product is relatively low.

These effervescent tablets are widely used in food and pharmaceutical fields because they can be easily consumed anywhere as long as there is drinking water.

An ideal effervescent tablet needs physical properties suitable for smooth production, transportation, packaging, storage, etc. along with the property of disintegrating quickly and gently in the oral cavity. Such physical properties include high hardness and low friability. Unfortunately, if the disintegration is fast, the physical properties of the tablet are bad, and if the physical properties are good, the disintegration is generally bad. Most effervescent tablets on the market find a suitable balance or compromise between the two, or focus on one side, but leave the deficient part to the consumer to fill in the precautions, or supplement it with other methods such as special packaging. Most of what has been

Effervescent tablet manufacturing technologies include freeze-drying, a method similar to the production of cotton candy, a method of containing an appropriate amount of a foaming agent in the tablet, a method of using a large amount of a disintegrant, a method of using high-dissolving sugars and high A method of using an appropriate combination of forming saccharides, a method of improving physical properties by treating the tablets obtained after low pressure tableting with humidification or heating, and a method of improving the tableting machine and spraying a lubricant into the mold in which the tablet is compressed. A method for producing a mixture without a tableting disorder is known.

However, many of the above effervescent tablet manufacturing technologies require special equipment or expensive equipment, or need to be specially improved because general pharmaceutical equipment cannot be used as it is. This may cause an increase in manufacturing cost, and may limit various applications. In addition, even when specific temperature and humidity conditions are required after tableting or tableting, unnecessary equipment investment and the tablet may be exposed to harsh conditions, thereby limiting its application.

On the other hand, red ginseng (紅蔘, red ginseng) is steamed and dried ginseng (Panax ginseng CA MEYER) belonging to the Araliaceae family. It acts as a representative herbal medicine in oriental medicine, and its primary treatment effects are Daebowongi, Napgipyungcheon, and Saengjinjigal. It works to prevent high blood pressure and arteriosclerosis, so it has a cardiac action, antioxidant action, anti-fatigue action, anti-radioactive action, and blood sugar lowering action. Main ingredients include saponin (ginsenosides), panaxynol, beta-elemene, maltol, and the like. Red ginseng extract has been used to treat anemia, diabetes, insomnia, gastritis, abnormal blood pressure, indigestion, overwork, and fatigue, and it is reported that it contains various triterpene glycosides called saponins.

The demand base for red ginseng products is wide, and there is a demand for products that satisfy the requirements such as functionality, convenience, and quick-acting properties due to the increasingly high-end consumer demands.

Republic of Korea Patent Registration No. 10-0638833 Republic of Korea Patent Publication No. 10-2012-0047607 Republic of Korea Patent Publication No. 10-2006-0119647

The present inventor solves the problems accompanying the prior art as described above, and develops a product that allows consumers to more easily access red ginseng products, is inexpensive, and satisfies the requirements such as functionality, convenience and fast disintegration characteristics. As a result of intensive research for this purpose, as described below, red ginseng effervescent tablets manufactured with turmeric extract and vitamin C, which are the main ingredients of red ginseng, licorice, and curcumin, as active ingredients, have antioxidant and fatigue recovery functions, while handling and convenience are improved. It has been found that it can satisfy the above requirements by exhibiting fast disintegration, and has led to the completion of the present invention.

Therefore, it is an object of the present invention to prepare a red ginseng effervescent tablet using red ginseng, turmeric and licorice extract and vitamin C as active ingredients, which has antioxidant and fatigue recovery functions, while improving handling and convenience, and exhibiting fast disintegration properties, and production thereof It's about providing a way.

The object of the present invention as such is that it contains 20-40 wt% of red ginseng powder, 7-12 wt% of vitamin C powder, 3-10 wt% of turmeric extract powder, 3-10 wt% of licorice extract powder, 45-55 wt% of composition for sokbung It can be achieved by the characterized red ginseng effervescent tablet and its manufacturing method.

The red ginseng effervescent tablet according to the present invention allows consumers to conveniently consume red ginseng products with improved functionality and palatability, and the active ingredients including the ingested red ginseng are rapidly disintegrated and absorbed, resulting in high bioavailability and low sodium content. It can provide desirable effects to consumers who

1 is a manufacturing process diagram of a red ginseng effervescent tablet according to an embodiment of the present invention.
Figure 2 is a sodium content test report of the red ginseng effervescent tablet and vitamin C effervescent tablet according to an embodiment of the present invention.
Figure 3 is a graph showing the antioxidant effect of the red ginseng effervescent tablet according to the present invention.

The present invention, in one aspect, comprising 20-40 wt% of red ginseng powder, 7-12 wt% of vitamin C powder, 3-10 wt% of turmeric extract powder, 3-10 wt% of licorice extract powder, 45-55 wt% of a composition for sokbung It provides a red ginseng effervescent tablet, characterized in that.

The present invention, in a further aspect,

a) extracting after pre-treatment of red ginseng, turmeric and licorice to prepare raw ingredients in powder form;

b) mixing 20-40 wt% of red ginseng powder, 7-12 wt% of vitamin C powder, 3-10 wt% of turmeric extract powder, and 3-10 wt% of licorice extract powder;

c) adding 45 to 55 wt% of the composition for fast disintegration to the mixture obtained in the above step, followed by agglomeration;

d) tabletting the agglomerated mixture using a tablet press to form a tablet;

e) drying the compressed tablets; and

It provides a method for producing effervescent red ginseng tablets comprising; f) packaging the dried tablets in a predetermined unit.

Hereinafter, preferred embodiments of a red ginseng effervescent tablet and a method for manufacturing the same according to the present invention will be described in detail with reference to the accompanying drawings.

The terms or words used in the present specification and claims are not to be construed as limited in their ordinary or dictionary meanings, and on the principle that the inventor can appropriately define the concept of the term in order to best describe his invention. It should be interpreted as meaning and concept consistent with the technical idea of the present invention. Therefore, since the embodiments described in this specification and the configurations shown in the drawings are only the most preferred embodiment of the present invention, it is understood that there may be various equivalents and modifications that can be substituted for them at the time of the present application. shall.

The red ginseng effervescent tablet according to the present invention includes red ginseng powder, vitamin C, turmeric extract and licorice extract as active ingredients.

Red ginseng, as the main component of the active ingredient exhibiting fatigue recovery and antioxidant effects, cooperates with vitamin C, turmeric extract, licorice extract and foaming composition to exert the desired antioxidant effect and fatigue relief.

Vitamin C strengthens the immune system and relieves symptoms such as weakness, anemia, high blood pressure, and inflammation.

Turmeric ( Curcuma longa ) is a perennial plant belonging to the ginger family, also called turmeric. Turmeric is known in old books such as 'Bonchogangmok' and 'Donguibogam' for its anti-inflammatory, anti-inflammatory, and anti-oxidative properties. Curcumin, an indicator component of turmeric, is a diketone and has strong antioxidant and cancer cell killing effects.

Licorice means perennial herbaceous plants belonging to the genus Glycyrrhiza. It is also called a plant. The licorice has a reddish-brown or dark-brown outer skin, has vertical wrinkles, and sometimes has bark, buds and scale leaves, has a peculiar smell and has a sweet taste. Xinjiang), refers to plants grown in Mongolia and cultivated or native to Korea. In oriental medicine, it has been used to harmonize the toxicity of all medicines so that the medicinal effects appear well, to control the cold and morale of the books, to communicate well all the blood vessels, and to strengthen the muscles and bones. Licorice used in the present invention may be collected from nature or purchased commercially, but is not limited thereto. Licorice, an active ingredient in the present invention, functions to gently neutralize the taste of turmeric and red ginseng.

The present invention is technically characterized in providing a foaming agent that synergistically exhibits fatigue recovery and antioxidant functions by an appropriate combination ratio of these main ingredients, and a suitable blending ratio of these ingredients is 20-40 wt% of red ginseng powder, 7-12 wt% of vitamin C powder %, turmeric extract powder 3-10wt%, licorice extract powder 3-10wt%, and it is preferable to include 45-55wt% of the composition for sokbung. When the composition of the active ingredient is out of the set range, there is a risk that the taste and the flavor are not balanced, so that they do not harmonize, and the antioxidant function and the function of recovering from fatigue may be deteriorated.

In particular, if the content of the main component is less than 45% by weight with respect to the composition for fast disintegration, there may be a problem in content uniformity, and if it exceeds 55% by weight, there is a fear that physical properties such as hardness or friability of the effervescent tablet may be deteriorated.

The composition for fast disintegration contains 25 to 35 parts by weight of sodium tartrate, 15 to 25 parts by weight of mannitol, 15 to 25 parts by weight of sodium bicarbonate, sucrose, chitosan and sodium alginate in the total content of the composition for fast disintegration 1:0.5 to 1:0.2 It is preferable to include in a weight ratio of 10 to 20 parts by weight of the binder and 3 to 10 parts by weight of magnesium stearate included in a weight ratio of 0.5.

The sodium stannate functions as a stabilizer, and is preferably used in an amount of 25 to 35 parts by weight of the total content of the composition for fast disintegration. If the content is out of the above range, there is a risk that the stability and buffering properties of the composition may be deteriorated.

As a sugar alcohol, mannitol is a component that provides the hardness, compressibility, and flowability of the fast-disintegrating tablet. It is well soluble in water, chemically stable, non-hygroscopic, and has a good taste when disintegrated in the oral cavity. The mannitol is preferably used in an amount of 15 to 25 parts by weight among the total content of the composition for rapid disintegration, and when the content of mannitol is out of the range set above, there is a fear that the hardness is low or the disintegration time is delayed.

The sodium bicarbonate functions to promote the disintegration of the formulation, and it may be appropriate to use 15 to 25 parts by weight of the total content of the composition for rapid disintegration. If it is included in less than 15 parts by weight of the total content of the composition for rapid disintegration out of this, foaming performance may be reduced, and when included in excess of 25 parts by weight, there is a fear that the effectiveness as a formulation may decrease due to a decrease in the content of other components.

The binder may be preferably used by mixing sucrose, chitosan, and sodium alginate in a weight ratio of 1:0.5 to 1:0.2 to 0.5 parts by weight with a solvent such as ethanol having the same weight. This binder component was selected as a component inducing rapid disintegration due to excellent solubility in water while high hardness of the tablet. Therefore, when the content of the binder is low, there may be a problem in that the hardness of the tablet is lowered, and if it exceeds a set range, there may be a problem in that the disintegration time is delayed.

The magnesium stearate is a component used as a lubricant to prevent agglomeration of the powder, to allow the tablet to be discharged well from the tableting die, and to harden the tablet to lower the friability of the tablet. The lubricant may preferably include 3 to 7 parts by weight of the total amount of the composition for fast disintegration. If it is out of this range, there is a risk of lowering the hardness of the tablet, delaying the disintegration time, and lowering the dissolution rate.

According to a more preferred embodiment of the present invention, the composition for fast disintegration may further contain excipients or additional ingredients commonly used in the art for the purpose of further improving the taste or appearance or storage stability of the tablet.

Specific types and contents of the excipients are well known in the art to which the present invention pertains, and may be modified in various categories.

Such ingredients may include a suspending agent that promotes foaming, for example, one selected from the group consisting of sorbitol, xylitol, dextrin, maltodextrin, lactose, starch, microcrystalline cellulose, crospovidone and dicalcium phosphate; A mixture of two or more may be used. The suspending agent may be preferably included in a weight ratio of 1 to 3 parts by weight in the total content of the composition for fast disintegration.

In addition, a sweetener may be additionally included, and aspartame, sugar, acesulfame potassium, stevioside, glucose, fructose, sodium saccharin and sucralose may be preferably used as the sweetener.

Likewise, more flavorings may be included, and flavorings include pineapple flavor, apple flavor, orange flavor, lemon flavor, grape flavor, cherry flavor, peach flavor, apricot flavor, strawberry flavor, mango flavor, lime flavor, melon flavor, plum flavor, mulberry flavor, mulberry flavor Incense, bokbunja incense, ginseng, red ginseng, jujube, ginger or citron may be preferably used.

Hereinafter, a method for manufacturing an effervescent tablet of red ginseng according to the present invention will be described. 1 is a manufacturing process diagram of a red ginseng effervescent tablet according to an embodiment of the present invention.

As shown in FIG. 1 , the effervescent tablet of red ginseng according to the present invention includes a raw material manufacturing step, a mixing step, a tableting step, a drying step and a packaging step. Hereinafter, each individual step will be described in detail.

a) raw material manufacturing stage

Red ginseng can be manufactured in a well-known conventional way, for example, by repeating the process of steaming ginseng at 80-100 ° C for 3 to 6 hours and then cooling it to 20-25 ° C 3 to 5 times. can In addition, the red ginseng may be dried and powdered or extracted and then concentrated to a high concentration and then used as a powder or granules.

Turmeric and licorice can be produced through an extraction step after pretreatment. It is preferable to use dried roots for turmeric and dried stems for licorice.

First, in the pretreatment step, it may be preferable to treat the vegetable materials including turmeric and licorice by a series of steps including a1) washing step, a2) drying step, a3) mincing step, and a4) mixing step.

First, in a1) washing step, turmeric and licorice are washed with clean water.

The washing removes foreign substances such as dust, soil, and insects in the vegetable material by spraying purified water to prevent deterioration of the quality of the final manufactured product by bacteria inhabiting the foreign substances in the subsequent process.

Then, in a2) drying step, the washed vegetable material is dried naturally or dried using a dryer.

In the case of natural drying, for example, spread the vegetable material to a thickness of 1 to 2 cm in a well-ventilated room, place it on a shelf or a net, and turn it over intermittently at room temperature for 12 to 30 hours to dry it so that the moisture is evenly evaporated.

On the other hand, when drying under direct sunlight, it is preferable to dry for 0.2 to 1 hour, preferably 0.5 to 1 hour, depending on the amount of sunlight.

In addition, when using a dryer, it may be preferable to dry it at a temperature of 50° C. or less for about 48 hours. In the drying step, it may be preferable to dry the material so that the moisture content of the material is 50 to 65% (w/w).

Subsequently, a3) mincing is mainly performed using a mincer, but it is not limited thereto as long as the stem or root is minced to an appropriate size, and the mincing size is preferably about 2 to 5 cm based on the length.

Then, in the mixing step a4), the chopped vegetable material is mixed in an appropriate suitable proportion and subjected to subsequent treatment.

Then, in the extraction step, it may be preferable to extract the active ingredient through b1) extraction, b2) filtration, b3) concentration, b4) drying, and b5) grinding.

b1) In the extraction step, put turmeric and licorice in an extractor, add 5 to 25 times water or an organic solvent based on the weight, and brew for 6 hours to 72 hours at 0.5 to 0.6 atm and medium temperature of 70°C to 95°C. Extraction may be desirable.

The organic solvent is methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1 , 3-butylene glycol, propylene glycol, or a mixed solvent thereof may be used.

There is a risk that the content of the active ingredient may be lowered when the medium temperature extraction condition is exceeded.

Then, in the filtration step b2), for example, using a filtration membrane, paper filter paper, non-woven fabric or cotton, etc. to filter out solid foreign substances and particles, or ultrafiltration, freezing filtration, centrifugal separation, etc. It can be filtered. In addition, filtration may be performed by first filtration using gauze and then secondary filtration using Whatman paper.

Subsequently, in the b3) concentration step, the obtained filtrate is concentrated at a temperature of 50 to 65° C. under a reduced pressure of -0.08 to -0.09 MPa for 4 to 8 hours so that the brix° of the solid content is 40 or more. The yield may be the best when it is concentrated under a reduced pressure of -0.08 to -0.09 MPa using a vacuum concentrator.

Then, in the drying step b4), the obtained concentrate is preferably dried under vacuum at a temperature of 55 to 65° C. for 24 to 48 hours.

b5) In the pulverizing step, as a process of pulverizing the concentrated extract of turmeric and licorice to 80-120 mesh, it may be preferable to pulverize to a particle size of 80 mesh or less using a pulverizer, a hammer mill or a pin mill.

b) mixing step

In the mixing step, the powdered red ginseng, turmeric extract, licorice extract and vitamin C prepared as described above are first homogeneously mixed.

c) agglomeration step

Then, a composition for fast disintegration including a liquid binder is added to the mixture in powder form within the range set above and agglomerated.

The mixing and agglomeration step may be performed using a mixer, a mixer, a high-speed mixer, or a manual method.

d) tableting step

The effervescent tablet according to the present invention can be manufactured using a tableting machine or a molding machine generally used in pharmaceutical processes.

The compression pressure used for compressing the mixture into a tablet is generally about 150 MPa or less (eg, 1 Pa to 150 MPa), preferably about 35 MPa or less, more preferably about 10 MPa or less. It may be desirable to perform

e) drying step

Mild conditions for drying the tablet may be conditions of room temperature that are not humid, for example, a temperature of 20 to 30° C. and a humidity of 40% or less. For faster and more reliable drying, a low-temperature convection oven of 20-50°C can be used, and a method of supplying dry air, a method of using a dehumidifier, or a method of using a desiccant can be used.

For example, the drying operation may be performed in a convection oven, a vacuum oven, a fluidized bed dryer, a dryer, natural drying at room temperature, or the like.

f) packaging step

The tablets dried in the above step are filled and packaged for each standard of a certain unit. Then, according to the standards and specifications, after inspecting the properties, foreign substances, moisture, number of bacteria, E. coli, etc., only suitable products are shipped.

The red ginseng effervescent tablet according to the present invention has excellent stability, as can be seen from the results of Examples and Test Examples to be described later, and can be used as a functional health food for the purpose of antioxidant efficacy and diet or fatigue recovery. In addition, it can be rapidly absorbed into the body, thereby exhibiting immediate effect.

Sodium is a kind of mineral that regulates various physiological functions in the body, such as water balance and acid-alkali balance in our body. Minerals cannot be synthesized in the body, so they must be consumed through food. Minerals can be obtained through various foods such as vegetables, fruits, meat, fish, etc. In the case of sodium, it is mainly consumed in the form of sodium chloride contained in salt. Sodium plays a role in transmitting stimulation to the body, and at this time, it is also important to balance with potassium, a kind of mineral. Sodium, along with potassium, maintains the balance of acids and alkalis in our body, and regulates the volume of plasma to maintain normal blood pressure. Insufficient sodium can cause anorexia, indigestion, lethargy, kidney disease, hypotension, and decreased liver function.

On the other hand, even a small increase in the concentration of sodium and potassium in plasma has a large effect on blood pressure and heart movement. When sodium intake is excessive, the volume of blood increases due to the water balance control function, which has a great effect on arterial blood pressure, causing high blood pressure or straining the kidneys. In a state of excessive sodium in the body, thirst, fatigue, sleep disturbance, edema, high blood pressure, etc. occur, and in severe cases, seizures may occur. In addition, research results have been published that excessive sodium intake promotes nervous anxiety, emotional anxiety, stress, and suicidal thoughts, and is also associated with gastric cancer, gastric ulcer, and osteoporosis.

The World Health Organization and the US National Institutes of Health have suggested that the daily salt intake for adults is 5g to 6g, and according to this standard, sodium corresponds to 2000mg and 2400mg.

Effervescent tablets distributed in the market have a problem in that an excess of sodium component remains when disintegrated by water.

(Example)

Hereinafter, the contents of the present invention will be described in detail through Examples and Test Examples. However, these are for describing the present invention in more detail, and the scope of the present invention is not limited thereto.

Preparation Example 1: Preparation of red ginseng extract

After 10 kg of ginseng is steamed at 95°C for 3 hours, cooled to 20°C is repeated 3 times to produce red ginseng, then chopped and dried while turning over intermittently at room temperature for 24 hours, and then made into powder using a grinder did.

Preparation Example 2: Preparation of turmeric and licorice extract powder

After washing each 5 kg of turmeric root and 5 kg of licorice stem with clean water, they spread evenly in a well-ventilated room, placed on a shelf, and dried while turning over intermittently for 24 hours at room temperature. Then, the stems and roots are cut into pieces of about 2-3 cm in size, pre-treated, put into an extractor, 20 times the weight of water or an organic solvent is added, and then at a temperature of 0.5 to 0.6 atm and 85° C. for 48 hours. After brewing and extracting it, filtering it with a nonwoven fabric, collecting the filtrate, concentrating the solid content at a temperature of 65°C under a reduced pressure of -0.08 to -0.09 MPa for 4 hours, and drying the concentrate at a temperature of 55°C under vacuum for 24 hours, then 80 mesh It was pulverized to a particle size of to obtain an extract powder.

The yield of the extract showed some difference depending on the solvent. In the case of purified water, turmeric showed 28.23% and licorice, 23.65%, and when the solvent was used as alcohol, turmeric showed a yield of 31.15% and licorice had a yield of 26.65%. .

Examples 1 to 6 and Comparative Example 1: Preparation of effervescent red ginseng tablets

Red ginseng powder, licorice extract powder and turmeric extract powder prepared in Preparation Examples 1 and 2 were first mixed with commercially purchased vitamin C, and then the composition for fast disintegration as shown in Table 1 was added and agglomerated under high-speed rotation. After tableting using a tablet press, it was dried at a temperature of 25° C. and a humidity of 40% or less to prepare effervescent red ginseng tablets having a diameter of 25 mm, a thickness of 6 mm, and a weight of 4.0 g. As a binder, ethanol of the same weight was mixed in a mixture of sucrose, chitosan, and sodium alginate in a weight ratio of 1:0.5:0.2 in Examples of the present invention, and microcrystalline cellulose was used in Comparative Example 1.

Ingredient content (g) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 red ginseng powder 200 250 300 300 350 400 500 vitamin C 120 100 90 80 70 70 50 Turmeric Extract Powder 100 70 70 30 50 30 - Licorice Extract Powder 100 30 50 70 50 50 - composition for fast disintegration 480 550 490 550 480 450 450 sodium stannate 25 copies 35 copies 35 copies 35 copies 35 copies 35 copies 25 copies mannitol 25 copies 15 copies 25 copies 25 copies 15 copies part 17 25 copies sodium bicarbonate 25 copies part 24 15 copies part 17 25 copies 25 copies 20 copies binder part 12 20 copies 20 copies 10 copies part 12 20 copies - magnesium stearate 10 copies Part 5 part 4 10 copies 10 copies Part 3 10 copies Microcrystalline Cellulose Part 3 chapter 1 chapter 1 Part 3 Part 3 0 copies 20 copies

Test Example 1: Physical property test of tablets

The tablets prepared in Examples were tested for physical properties according to the test method shown below, and the results are shown in Table 2 below.

[Hardness measurement]

The hardness of the tablet was measured using a hardness tester 8M (Hardness tester 8M, Dr. Schleuniger, Switzerland), and the average value was recorded by measuring at least 6 samples.

[Measurement of Friability]

It was tested according to the method for measuring tablet friability described in the Tablet Friability of the General chapters for general testing and analysis of USP (US Pharmacopoeia) 25.

[Underwater disintegration test]

It was tested according to the disintegration test method tablet section of the general test method of the 8th edition of the Korean Pharmacopoeia. Water was used as the test solution, and the test was performed using 6 samples at 37°C, and the average value was described.

[Oral disintegration test]

In the case of a rapidly disintegrating tablet, a disintegration test of the rapidly disintegrating tablet in the oral cavity was performed on volunteers. After the volunteers were randomly selected to rinse their mouths with water, the tablets were placed on the volunteers' tongues and the disintegration time was measured immediately by operating a stopwatch. Volunteers were allowed to use their tongue to move the fast-disintegrating tablet to the roof of the mouth and to roll the tablet from side to side or gently roll it without biting it. The stopwatch was stopped and the time recorded as soon as the tablet had disintegrated and was ready for swallowing with saliva.

[Dry Loss]

In the case of loss on drying such as powder or granules, take a sample of about 2 g, spread it evenly on an aluminum plate, and measure for several to ten minutes at 105 ° C using Sartorius' MA100 LOD meter. The test was allowed to end.

In the case of loss on drying of tablets, a sample corresponding to about 2 g was taken, placed in an aluminum plate, and measured in the same manner as for measurement of loss on drying of powders or granules.

[Content Uniformity]

It was tested according to the content uniformity test method in the Korean Pharmacopoeia formulation uniformity test method. Take 1 tablet of the test drug, put it in 5 ml of mobile phase, shake and mix to completely disintegrate, centrifuge the solution, and filter the supernatant with a membrane filter having a pore diameter of 0.45 μm. About 2 ml of the first filtrate was discarded, and the next filtrate was taken as the sample solution. 10 μl of the sample solution was tested according to the liquid chromatography method of the Korean Pharmacopoeia, but was detected at a wavelength of 254 nm using an appropriate column and flow rate. The preparation of the mobile phase was as follows: phosphoric acid diluted in 0.05 mol/l potassium dihydrogen phosphate TS was added to adjust the pH to 4.0, and to 800 ml of this solution, 100 ml of methanol and 100 ml of tetrahydrofuran were added.

Test Items Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Hardness (Kp) 4.2 4.2 4.1 4.3 4.3 4.2 2.7 Refining Fragility (%) 0.3 0.3 0.3 0.3 0.3 0.3 0.7 Underwater disintegration time (sec) 20.1 20.3 20.3 20.2 20.1 20.3 35.2 Oral disintegration time (sec) 17 18 17 16 15 18 32.2 Loss on drying (%) 0.82 0.85 0.86 0.83 0.81 0.86 1.25 Content uniformity (%) 3.3 3.2 3.2 3.2 3.1 3.1 3.6

As can be seen from the above test results, the product of Examples of the present invention satisfies all the standard requirements, whereas the product of Comparative Example 1 only satisfies the minimum standards.

Test Example 2: Measurement of sodium content

The effervescent tablet according to an embodiment of the present invention was foamed in water at 60° C., and the sodium content was analyzed by an external testing institution. As a comparative product, a commercial product (vitamin C of G Pharmaceutical) was used. The results are shown in Table 3 and FIG. 2 . Figure 2 is a sodium content test report of the red ginseng effervescent tablet and vitamin C effervescent tablet according to an embodiment of the present invention.

division Example 3 Comparative Example 1 sodium content 50.83mg 350mg

As shown in Table 3, it can be seen that the effervescent tablet according to an embodiment of the present invention has a reduction of 85% in sodium content. In addition, as shown in the test report shown in FIG. 2 , 80.910 g of sodium was detected in 1000 g of the effervescent tablet according to the embodiment of the present invention.

Test Example 3: Measurement of DPPH antioxidant effect

DPPH free radical scavenging experiments were performed on the samples of Examples 1 to 6 and Comparative Example 1. DPPH (1,1-diphenyl-2-picrylhydrazyl) itself is a very stable free radical, measuring a dark purple compound that exhibits specific light absorption at 517 nm, and is an antioxidant with radical scavenging activity. Antioxidant activity can be easily measured due to quantitative decolorization by Since the scavenging activity by these radicals is correlated with antioxidant activity including lipid peroxidation inhibitory activity, it is widely used in the search for antioxidants. Measurement of antioxidant activity (electron donating abilities, EDA) of the sample was measured by modifying the method of Blois. A sample extract of a certain concentration and DPPH solution (5 mg/100 mL methanol) were mixed in equal amounts, and then reacted at room temperature for 20 minutes, and then absorbance was measured at 517 nm. The electron donating effect was expressed as the absorbance reduction rate of the sample solution with and without addition. The resulting free radical scavenging ability was calculated by the following formula.

Free radical scavenging activity (%) = {1-(B/A)}×100

In the formula, A: the absorbance of the control well not treated with the sample, and B: the absorbance of the well of the experimental group treated with the sample. The results are shown in Table 4 and FIG. 3 .

Ex1 Ex2 Ex3 Ex4 Ex5 Ex6 Comp. Ex1 DPPH free radical-scavenging activity (%)
86.32
85.72
85.52
84.36
85.24
84.65
25.51

Through the above results, it could be confirmed that the samples of Examples 1 to 6 generally exhibited superior DPPH free radical scavenging ability compared to those of Comparative Examples.

Test Example 4: Sensory evaluation

A sensory test was performed on the effervescent tablets of red ginseng of Examples 1 to 6 and Comparative Example 1. The panel selected 30 trained inspectors, evaluated the appearance, flavor, taste, and overall preference according to the following five-point scale method, averaged each value, and the results are shown in Table 5 below. The evaluation criteria were set as 5 for very good, 4 for slightly good, 3 for moderate, 2 for poor, and 1 for very poor.

Evaluation items Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 taste 4.3±0.4 4.4±0.3 4.4±0.3 4.5±0.6 4.5±0.5 4.4±0.2 3.1±0.3 incense 4.3±0.2 4.5±0.3 4.5±0.4 4.4±0.3 4.4±0.3 4.4±0.5 2.5±0.3 refreshing 4.4±0.2 4.5±0.3 4.3±0.3 4.3±0.3 4.3±0.6 4.3±0.3 3.1±0.5 Comprehensive evaluation 4.5±0.4 4.4±0.1 4.4±0.3 4.3±0.4 4.4±0.2 4.4±0.2 2.4±0.4

As a result of the sensory test, the product of Example was significantly different from that of Comparative Example in terms of taste, aroma, and freshness, and was generally excellent.

Although preferred embodiments of the present invention have been described as described above, those skilled in the art will understand that various modifications and changes can be made to the present invention within the scope without departing from the spirit and scope of the present invention as set forth in the claims below. will be able

Claims (4)

delete delete a) extracting after pretreatment of red ginseng, turmeric and licorice to prepare raw ingredients in the form of red ginseng powder, turmeric extract powder and licorice extract powder;
b) preparing a mixture by mixing 300 g of the red ginseng powder, 90 g of vitamin C powder, 70 g of turmeric extract powder and 50 g of licorice extract powder;
c) agglomeration after adding 490 g of the composition for fast disintegration to the mixture;
d) tabletting the agglomerated mixture using a tablet press to form tablets in the form of pills;
e) drying the compressed tablet; and
f) packaging the dried tablets in a predetermined unit,
In the step a) red ginseng, turmeric and licorice extract are pre-treated and extracted to prepare raw ingredients in the form of red ginseng powder, turmeric extract powder and licorice extract powder,
The red ginseng powder is prepared by repeating the process of steaming 10 kg of ginseng at 95° C. for 3 hours and then cooling it to 20° C. three times, then chopping the red ginseng, drying it at room temperature for 24 hours, and then pulverizing it with a grinder. One red ginseng powder is used,
The turmeric extract powder and licorice extract powder were washed with 5 kg of turmeric root and 5 kg of licorice stem, respectively, and dried at room temperature for 24 hours, and the dried turmeric root and licorice stem were cut into 2 to 3 cm size and pre-treated. Then put it in the extractor, add water 20 times by weight based on the total weight of the dried turmeric root and licorice stem, and then brew and extract for 48 hours at 0.5 to 0.6 atm and a temperature of 85 ℃ to prepare an extract, The extract was filtered, the filtrate was collected, and the solid was concentrated at a temperature of 65° C. under a reduced pressure of -0.08 to -0.09 MPa for 4 hours to prepare a concentrate, and the concentrate was dried at a temperature of 55° C. under vacuum for 24 hours. Using turmeric extract powder and licorice extract powder prepared by grinding to a particle size of 80 mesh,
In the step c) after adding 490 g of the composition for fast disintegration to the mixture, in the step of agglomeration, the composition for fast disintegration is sodium tartrate 35 parts by weight, mannitol 25 parts by weight, sodium hydrogen carbonate 15 parts by weight, binder 20 parts by weight among the total content of the composition for fast disintegration parts and magnesium stearate in a weight ratio of 4 parts by weight, and the binder is prepared by mixing the same weight of ethanol with a mixture of sucrose, chitosan and sodium alginate in a weight ratio of 1:0.5:0.2 A method for manufacturing effervescent tablets of red ginseng. delete

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