KR20200088762A - Method for producing red ginseng ball loaded with effective component and red ginseng ball loaded with effective component produced by the same method - Google Patents

Abstract

The present invention relates to a method for manufacturing a red ginseng ball containing useful ingredients, and a red ginseng ball containing useful ingredients manufactured by the method. A variety of useful ingredients can be collected in the red ginseng ball of the present invention, so that the red ginseng ball is expected to be useful as a cosmetic and health functional food composition for enhancing antioxidant, wrinkle improvement, whitening, skin barrier improvement or moisturizing effect.

Description

Method for producing red ginseng ball loaded with effective component and red ginseng ball loaded with effective component and red ginseng ball loaded with effective component produced by the same method

The present invention relates to a method for manufacturing a red ginseng ball collecting useful components and a red ginseng ball collecting useful components prepared by the above method.

Korean ginseng ( Panax ginseng ) is a perennial herbaceous species of the genus Panax ginseng , Araliaceae, and in Chinese medicine, the root is called ginseng radix and is used for medicinal purposes. The pharmacological efficacy is described in detail and in Shinnongbonchogyeong (神農本草經), the best herbal in China. These ginseng have been used as medicines or traditional foods for the purpose of maintaining health since ancient times. In particular, Korean ginseng in Korea is a souvenir that has been recognized worldwide and has been widely traded to Europe and the Arab region during the Goryeo Dynasty.

Ginseng differs depending on the cultivation environment and conditions, but usually contains about 75% of moisture, so it is difficult to store for a long time in a mined state, and there is a risk of deterioration during distribution. Because the ginseng ingredient is decomposed to reduce product value and efficacy, it is mainly processed and sold immediately after cultivation.

Saponins in ginseng are also called ginsenosides because of their different chemical structure and medicinal properties from those found in common plants. It is known that such ginseng saponins have a large molecular weight and are hardly degraded by bio-digestive enzymes even when ingested, and are absorbed after being decomposed by microorganisms in the gut. However, when ingesting ginseng or ginseng saponin, the effect of saponin cannot be uniformly obtained because there are individual differences in the type, concentration, and activity of intestinal microbes for each person ingested.

Ginseng is generally divided into white ginseng and red ginseng according to the processing method, and white ginseng is dried unprocessed ginseng, or ginseng, mined in the field, and red ginseng is dried by steaming ginseng and dried, and saponin modification and amino acid change during manufacturing. Several chemical changes, such as browning, are involved. In particular, saponin components such as ginsenosides Rg2, Rg3, Rhl, and Rh2, which are unique components of red ginseng that are not present in ginseng, are newly generated due to heat generated during the production of red ginseng. It is known that it has growth inhibitory action, blood pressure lowering action, brain nerve cell protection and learning ability improvement action, antithrombotic action, antioxidant action, etc., so it can be expected to have excellent pharmacological efficacy of red ginseng.

Recently, studies using drug carriers such as liposomes are actively underway to increase the absorption of ginseng saponins into the body. Liposomes are artificially produced vesicles composed of lipid bilayers and have a structure similar to a biological cell membrane. Liposomes are composed of phospholipids, which are the main components of the biomembrane membrane, and are bio-friendly, and exist in the form of capsules surrounding hydrophilic and hydrophobic substances in a lipid bilayer of liposomes in aqueous solution. These liposomes have the advantage of being able to store desired useful substances (drugs, nutrients, etc.) in a bi-layer structure, which can transport unstable and difficult-to-handle substances into cells. However, despite these advantages, liposomes have unstable formulations, have very low collection efficiency, and have a problem that solvents, preservatives, and the like used to prepare liposomes cause skin irritation.

On the other hand, Korean Patent Publication No. 2017-0025528 discloses'a natural liposome containing red ginseng, a method for manufacturing the same, and a food, pharmaceutical or cosmetic composition containing the same,' related to natural liposomes in which red ginseng extract is collected, but useful components of the present invention There is no description of the production method of the red ginseng balls collected and the red ginseng balls collected useful components prepared by the above method.

The present invention has been derived by the above-mentioned demands, and the present inventors prepare red ginseng balls in a spherical form in which red ginseng concentrate collects useful components while mixing and ultrasonically treating red ginseng concentrate and useful components to form a film (outer membrane). Did. In addition, the present invention was completed by confirming that the prepared red ginseng ball has excellent skin absorption and high temperature stability.

In order to solve the above problems, the present invention comprises the steps of (1) mixing red ginseng concentrate, cyclodextrin and water and ultrasonicating to prepare an emulsifier; (2) mixing the yam powder and guarana powder, which are water-phase components, in the emulsifier of step (1) and ultrasonicating to prepare mixture 1; (3) adding the coconut palm oil fermentation product and useful components, which are oily components, to the mixture 1 of the step (2) and ultrasonically treating it to prepare a mixture 2; And (4) adding grapefruit extract and water to the mixture 2 of the step (3) and sonication; including a method for manufacturing a red ginseng ball containing useful components and collecting useful components prepared by the above method. Provide red ginseng balls.

In addition, the present invention provides a cosmetic composition comprising the red ginseng balls collected as the useful component as an active ingredient.

In addition, the present invention provides a health functional food composition comprising the red ginseng balls collected as useful components as an active ingredient.

The red ginseng balls of the present invention can capture various useful ingredients in a film made of red ginseng concentrate, and improve the effectiveness of useful ingredients by increasing the skin absorption rate of the useful ingredients, thereby improving antioxidant, skin moisturizing, wrinkle improvement or skin barrier improvement. It is expected to be useful as a cosmetic or health functional food composition with.

1 is a photograph of the red ginseng balls (see Table 1 below) of Comparative Example 1 and Preparation Examples 1 to 5 of the present invention observed with a scanning electron microscope. Measurement magnification: 100,000 times
2 is a particle size analysis result of the red ginseng balls of Comparative Example 1 and Preparation Examples 1 to 5 of the present invention.
Figure 3 is a result of measuring the zeta potential of the red ginseng balls of Comparative Example 1 and Preparation Examples 1 to 5 of the present invention.
4 is a result of measuring the skin absorption rate (B) of the red ginseng balls of Comparative Example 1 and Preparation Examples 1 to 5 of the present invention through a transdermal absorption diffusion test (Franz Diffusion Cell, A).
5 and 6 are the results confirming the stability of the red ginseng balls of Comparative Example 1 and Preparation Examples 1 to 5 of the present invention at high temperature (60° C.) conditions.

In order to achieve the object of the present invention, the present invention

(1) preparing an emulsifier by mixing red ginseng concentrate, cyclodextrin and water and ultrasonicating;

(2) mixing the yam powder and guarana powder, which are water-phase components, in the emulsifier of step (1) and ultrasonicating to prepare mixture 1;

(3) adding the coconut palm oil fermentation product and useful components, which are oily components, to the mixture 1 of the step (2) and ultrasonically treating it to prepare a mixture 2; And

(4) adding the grapefruit extract and water to the mixture 2 of the step (3) and sonication; providing a method for producing a red ginseng ball containing useful components.

In the method according to an embodiment of the present invention, the red ginseng concentrate of step (1) contains a large amount of saponin, and the saponin has a structure similar to that of the phospholipid, which is a major component of the cell membrane, so that the red ginseng ball coating (envelope) is formed. It can form and trap useful ingredients inside the red ginseng balls. In addition, the cyclodextrin of the step (1) serves to coat the outside of the red ginseng ball, that is, the outer coating of the red ginseng ball.

In the method according to an embodiment of the present invention, the yam powder of step (2) helps to form a film of red ginseng balls, and guarana powder can enhance the skin absorption of red ginseng balls with useful components.

In the method according to one embodiment of the present invention, the coconut palm oil fermentation product of step (3) is excellent in reducing the particle size of the red ginseng balls by collecting useful ingredients by helping to form the red ginseng balls. . In addition, the useful components of step (3) include vitamins, hyaluronic acid, glycerin, amino acids, natural moisturizing factor, 1,3-butylene glycol, polyethylene glycol, glucose, urea, sorbitol, lactic acid, gluco It can be ronic acid, galactose, propylene glycol, isopropyl myristate, inorganic ionic components, triglyceride, mineral oil, silicone, squalene, ceramides, cholesterol, cholesterol, wax, lecithin, etc., It may be preferably a vitamin, and more preferably vitamin D3, but is not limited thereto.

In the method according to an embodiment of the present invention, the grapefruit extract of step (4) is a natural preservative, and serves to prevent the decay of useful components collected in the red ginseng balls and red ginseng balls made of red ginseng concentrate.

In the method according to an embodiment of the present invention, the method for manufacturing the red ginseng ball in which the useful component is collected is specifically,

(1) mixing red ginseng concentrate 1.5-4.5 g, cyclodextrin 1-5 g, and water 20-40 ml, and sonicating for 10 minutes at 10-50 Amp for 1-3 minutes to prepare an emulsifier;

(2) Mixing 0.1-5 g of yam powder as an aqueous phase component and 0.1-5 g of guarana powder in the emulsifier of step (1), and sonicating for 1 to 3 minutes under 10 to 50 Amp conditions to prepare mixture 1 ;

(3) To the mixture 1 of the step (2), 0.05 to 5 g of coconut palm oil fermentation as an oily component and 0.05 to 5 g of useful components were added, followed by sonication for 4 to 6 minutes under 10 to 50 Amp conditions to mix 2 Preparing a; And

(4) the mixture of step (3) to the grapefruit extract 0.01-2 ml and 55-70 ml of water is added to the mixture 2 of step and sonicated for 4-6 minutes under 10-50 Amp conditions; may include,

More specifically,

(1) preparing an emulsifier by mixing 3.5 g of red ginseng concentrate, 2 g of cyclodextrin and 30 ml of water and sonicating for 2 minutes 30 seconds under 30 Amp conditions;

(2) mixing 2 g of yam powder and 1 g of guarana powder, which are water-phase components, in the emulsifier of step (1) and sonicating for 2 minutes 30 seconds under 30 Amp conditions to prepare mixture 1;

(3) adding 1.5 g of coconut palm oil fermentation material and 1 g of useful components to the mixture 1 of the step (2) and sonicating for 5 minutes under 30 Amp conditions to prepare mixture 2; And

(4) adding 1 ml of grapefruit extract and 58 ml of water to mixture 2 of step (3) and sonicating for 5 minutes under 30 Amp condition; but may not include, but is not limited to.

The present invention also provides a red ginseng ball collected useful components prepared by the above method.

In the present invention, it is expected that the saponin contained in red ginseng has a structure similar to that of phospholipids, and thus is expected to play a role of phospholipids. Thus, a red ginseng ball in the form of a red ginseng concentrate-captured useful component was prepared. In addition, yam powder and coconut palm oil fermentation products used in the production of red ginseng balls also help to form a film of red ginseng balls, thereby reducing the particle size of red ginseng balls with useful ingredients.

The red ginseng ball has excellent solubility and stability, and has a high skin absorption rate when applied to the skin, so that useful ingredients can be delivered deep into the skin.

The present invention also provides a cosmetic composition comprising the red ginseng balls collected as useful components as an active ingredient.

The cosmetic composition of the present invention contains red ginseng balls in the form of a red ginseng concentrate containing useful ingredients as an active ingredient, and depending on the type of useful ingredients collected, the cosmetic compositions have antioxidant, wrinkle improvement, whitening, and skin barrier improvement And it may have any one use selected from the group consisting of moisturizing, but is not limited thereto.

The cosmetic composition of the present invention includes skin, skin softener, skin toner, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, eye cream, moisture cream, hand cream, essence, nutrition essence, pack, cleansing foam , Cleansing water, cleansing cream, body lotion, body cleanser, soap and powder may have any one selected from the formulation, but is not limited thereto. The cosmetic composition composed of each of these formulations may contain various carriers and additives necessary and appropriate for the formulation of the formulation, and the types and amounts of these components can be easily selected by those skilled in the art.

When the formulation of the cosmetic composition of the present invention is a paste, cream, or gel, animal fibers, plant fibers, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as carrier components Etc. can be used.

When the formulation of the cosmetic composition of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in the case of a spray, additionally, chlorofluorohydro Propellants such as carbon, propane-butane or dimethyl ether.

When the formulation of the cosmetic composition of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, and propylene Glycols, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the cosmetic composition of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol as a carrier component, an ethoxylated isostearyl alcohol, a suspension agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.

When the formulation of the cosmetic composition of the present invention is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, acethionate, imidazolinium derivative, methyltaurate, sarcosinate as a carrier component , Fatty acid amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linoline derivatives or ethoxylated glycerol fatty acid esters and the like.

The cosmetic composition of the present invention may further contain excipients including fluorescent materials, fungicides, oleogenic agents, moisturizers, fragrances, fragrance carriers, proteins, solubilizers, sugar derivatives, sunscreens, vitamins, plant extracts, etc. .

The present invention also provides a health functional food composition comprising the red ginseng balls collected as useful components as an active ingredient.

In the health functional food composition of the present invention, the red ginseng balls in which the useful components are collected are as described above.

The health functional food composition may be prepared in any one form selected from powder, granule, pill, tablet, capsule, candy, syrup, effervescent tablet, and beverage, but is not limited thereto.

The health functional food composition may have any one use selected from the group consisting of antioxidant, wrinkle improvement, whitening, skin barrier improvement and moisturizing, but is not limited thereto.

When using the red ginseng ball collected the useful component of the present invention as a food additive, the red ginseng ball collected the useful component can be added as it is or used with other food or food components, and can be suitably used according to a conventional method. have. The active ingredient may be appropriately used depending on its purpose of use (prevention or improvement). In general, red ginseng balls collected with the useful components of the present invention in the manufacture of food or beverages are added in an amount of 15 parts by weight or less, preferably 10 parts by weight or less with respect to the raw materials. However, in the case of long-term intake for the purpose of health control, it can be used in an amount that does not have any problem in terms of safety.

There are no particular restrictions on the type of food. Examples of foods to which the health functional food composition can be added are meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum products, dairy products including ice cream, various soups, beverages, tea Drinks, alcoholic beverages, and vitamin complexes are included, and all foods in the ordinary sense are included. The beverage includes carbonated beverages, functional ionic beverages, juices (for example, apples, pears, grapes, aloe, tangerines, peaches, carrots, tomato juices, etc.), sikhye, and the like.

The functional food of the present invention includes ingredients that are commonly added in food preparation, and includes, for example, proteins, carbohydrates, fats, nutrients, and seasonings. For example, when prepared as a drink agent, natural carbohydrates or flavoring agents may be included as additional ingredients in addition to the active ingredient. The natural carbohydrates include monosaccharides (e.g. glucose, fructose, etc.), disaccharides (e.g. maltose, sucrose, etc.), oligosaccharides, polysaccharides (e.g. dextrins, cyclodextrins, etc.) or sugar alcohols (e.g. , Xylitol, sorbitol, erythritol, and the like). The flavoring agent may be a natural flavoring agent (eg, tau martin, stevia extract, etc.) and a synthetic flavoring agent (eg, saccharin, aspartame, etc.). Various nutritional supplements, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonic acid It may further contain a carbonation agent used in beverages.

Hereinafter, the present invention will be described in detail by examples. However, the following examples are only to illustrate the present invention, the content of the present invention is not limited to the following examples.

Manufacturing example 1. Preparation of red ginseng balls with useful ingredients

2 g and 30 ml of 2 ml 30 g of a ginsenoside containing 2 mg of cyclodextrin and 30 ml of distilled water were mixed with 3.5 g of 6-year-old red ginseng concentrate containing 23 mg and using an ultrasonic crusher (Qsonica sonicators, TUVRheinland) for 2 minutes and 30 seconds. The emulsifier was prepared by treatment (A in Table 1 below). Mixture 1 was prepared by mixing the above prepared emulsifier with 2 g of yam powder and 1 g of guarana powder and sonicating for 2 minutes 30 seconds under 30 Amp conditions (B in Table 1 below). Mixture 2 was prepared by adding 1.5 g of the coconut palm oil fermentation product, an oily component, and 1 g of useful ingredients (vitamin D3 powder) to be collected and sonicating for 5 minutes under 30 Amp condition (Table 1 below). C). To the mixture 2, 1 ml of grapefruit extract and 58 ml of water were added and subjected to ultrasonic treatment for 5 minutes under conditions (D in Table 1 below) to prepare a red ginseng ball in the form of a red ginseng concentrate containing vitamin D3 (below). Preparation Example 1 of Table 1). In addition, various red ginseng balls were prepared by varying the contents of each component as described in Table 1 below.

Example 2. Particle analysis of red ginseng balls with useful ingredients

2-1. Scanning electron microscope observation

Red ginseng balls of Preparation Examples 1 to 5 and Comparative Example 1 of Table 1 were observed with a scanning electron microscope (HITACHI FE SEM S-4700). As a result, Comparative Example 1 (not including red ginseng concentrate), Production Example 4 and Production Example 5 showed a non-constant sphere shape, whereas Production Examples 1 to 3 containing the red ginseng concentrate exhibited a constant sphere shape, especially in manufacturing. It was confirmed that the red ginseng balls of Example 1 were in the shape of a sphere having the smallest size (FIG. 1 ).

In addition, through the results of Preparation Examples 1, 4, and 5, when the red ginseng concentrate is added to 1 g or 5 g of the red ginseng concentrate when the red ginseng ball is prepared, it can be seen that it is possible to manufacture a regular spherical red ginseng ball. Could.

2-2. Particle size measurement

As a result of measuring the particle size of the red ginseng balls of Preparation Examples 1 to 5 and Comparative Example 1 using a zeta potential measuring device (ELS-8000, OTSUKA), Comparative Example 1 was 1000.9 nm, Preparation Example 1 was 174.6 nm, Preparation Example 2 was 187.5 nm, Preparation Example 3 was 1256.3 nm, Preparation Example 4 was found to be 171.6 nm, and Preparation Example 5 was 283.4 nm (FIG. 2).

2-3. Zeta potential measurement

As a result of measuring the zeta potential of the red ginseng balls of Preparation Examples 1 to 5 and Comparative Example 1 using a zeta potential measuring device (ELS-8000, OTSUKA), Comparative Example 1 was -12.39 mV, Preparation Example 1 was It was confirmed that -20.27 mV, Production Example 2 was -17.20 mV, Production Example 3 was -12.90 mV, Production Example 4 was -10.60 mV, and Production Example 5 was -16.50 mV (FIG. 3). If the absolute value of zeta potential is large, it means that the particles are stable and evenly formed, and therefore, the red ginseng ball of Preparation Example 1 having the largest absolute value was considered to be the most stable.

Accordingly, when the results of the scanning microscopic observation, particle size measurement, and zeta potential measurement are combined, red ginseng concentrate, cyclodextrin, yam powder, guarana powder, coconut palm oil fermentation product, vitamin D3 powder, grapefruit extract, and preparation example 1 prepared from water It was thought that the red ginseng balls of Ssangyong had the smallest particle size and were stable, and thus the best absorbency.

Example 3. Measurement of skin absorption of red ginseng balls with useful ingredients

A transdermal absorption diffusion test (Franz Diffusion Cell) was performed to confirm the skin absorption rate of red ginseng balls with useful components.

As a result, the absorption power increased in the red ginseng ball-treated group of Preparation Examples 1 to 5 containing the red ginseng concentrate compared to the comparative example 1-treated group not containing the red ginseng concentrate, in particular, the red ginseng concentrate, yam, involved in the film formation of the red ginseng ball It was confirmed that the absorption power was the best in the red ginseng ball treatment group of Preparation Example 1 in which both the powder and coconut palm oil fermentation were included (FIG. 4B).

Example 4. Stability analysis of red ginseng balls with useful ingredients

As a result of reacting the red ginseng ball stock solution of Comparative Example 1 and Preparation Examples 1 to 5 in Table 1 under high temperature (60° C.) for one week, Preparation Examples 1 to 4 were sufficiently dissolved to observe particles, but the red ginseng concentrate In Production Example 5, which contained a large amount, it was confirmed that all of the red ginseng balls were dissolved and particles were observed from the first day of the reaction to be unstable (formulation separation) (FIGS. 5 and 6 ).

Claims (7)

(1) preparing an emulsifier by mixing red ginseng concentrate, cyclodextrin and water and ultrasonicating the mixture;
(2) mixing the yam powder and guarana powder, which are water-phase components, in the emulsifier of step (1) and ultrasonicating to prepare mixture 1;
(3) adding the coconut palm oil fermentation product and useful components, which are oily components, to the mixture 1 of the step (2) and ultrasonically treating it to prepare a mixture 2; And
(4) adding the grapefruit extract and water to the mixture 2 of the step (3) and sonicating; comprising a method of manufacturing red ginseng balls containing useful ingredients. The method according to claim 1, wherein the useful component of step (3) is vitamin, hyaluronic acid, glycerin, amino acid, natural moisturizing factor, 1,3-butylene glycol, polyethylene glycol, glucose, urea, sorbitol, Lactic acid, glucuronic acid, galactose, propylene glycol, isopropyl myristate, inorganic ionic components, triglyceride, mineral oil, silicone, squalene, ceramides, cholesterol, cholesterol, wax and lecithin Method for producing a red ginseng ball with a useful component, characterized in that at least one selected from the group consisting of. According to claim 1,
(1) mixing the red ginseng concentrate 1.5 ~ 4.5 g, cyclodextrin (cyclodextrin) 1 ~ 5 g and water 20 ~ 40 ml to prepare an emulsifier by ultrasonic treatment;
(2) preparing the mixture 1 by mixing 0.1-5 g of yam powder as an aqueous phase component and 0.1-5 g of guarana powder with the emulsifier of step (1) and sonicating;
(3) adding step 5 to 5 g of coconut palm oil fermentation material and useful component 0.05 to 5 g as an oily component to mixture 1 of step (2) and sonicating to prepare mixture 2; And
(4) adding the grapefruit extract 0.01 to 2 ml and 55 to 70 ml of water to the mixture 2 of the step (3) and ultrasonically treating it; a method for producing red ginseng balls containing useful ingredients, comprising Claims 1 to 3 of red ginseng balls collected useful components prepared by the method of any one of claims. A cosmetic composition comprising red ginseng balls collected from the useful ingredients of claim 4 as an active ingredient. The cosmetic composition according to claim 5, wherein the cosmetic composition has any one selected from the group consisting of antioxidant, wrinkle improvement, whitening, skin barrier improvement and moisturizing. A health functional food composition comprising red ginseng balls collected from the useful ingredients of claim 4 as an active ingredient.

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