JP2007238509A - Agent for ameliorating skin symptom, supplement, food, beverage and pharmaceutical for ameliorating skin symptom containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an agent for ameliorating skin symptoms, a supplement for ameliorating skin symptoms, food for ameliorating skin symptoms, beverage for ameliorating skin symptoms, a pharmaceutical agent for ameliorating skin symptoms and a skin cosmetic material excellent in skin amelioration effect and safe when applied to the skin. <P>SOLUTION: The agent for ameliorating skin symptoms contains an extract of Cimicifuga recemosa as an active ingredient. The supplement for ameliorating skin symptoms containing the extract of Cimicifuga recemosa as an active ingredient, the food for ameliorating skin symptoms, the beverage for ameliorating skin symptoms, the skin cosmetic material and the pharmaceutical agent for ameliorating skin symptoms containing the extract of Cimicifuga recemosa as an active ingredient are provided. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a natural product-derived skin symptom improving agent, a supplement for improving skin symptom containing the same, food, beverage and medicine.

  In order to improve skin symptoms such as skin roughness, dullness, and wrinkles, beauty foods and drinks and skin cosmetics containing various natural products have been proposed.

For example, a skin beautifying composition comprising a skin cosmetic containing a leaf leaf extract and a cosmetic food and drink (Patent Document 1), a skin beautifying agent containing Sphingoemilin (Patent Document 2), and an extract of black rice or black rice bran. (Patent Document 3), Cell Activator consisting of Kaurell paracemosa algae extract, Skin external preparation and food (Patent Document 4), Oral skin improving agent and food composition for skin improvement containing eggshell membrane or hydrolyzate thereof (Patent Literature 5), a food for preventing or improving dry skin containing persimmon leaves or persimmon leaf extract (Patent Literature 6), and a composition for beautifying skin containing litchi seed extract (Patent Literature 7) An agent for improving the prevention of rough skin caused by stress, an extract containing perilla and lacan, a cosmetic composition and a food and drink (Patent Document 8), and a composition for beautifying skin food and drink containing a partial degradation product of guar gum enzyme (Patent Document 9) It has been known.
JP 2006-45092 A JP-A-2005-281257 JP 2004-99578 A JP 2004-10559 A JP 2003-246741 A JP 2003-135026 A JP 2003-63926 A JP 2001-139083 A JP 2000-125828 A

  However, it cannot be said that the skin symptom improving agent and food / beverage products for improving skin symptom of the prior art show sufficient effects. The problem to be solved by the present invention is a skin symptom improving agent, a supplement for improving skin symptom, a food for improving skin symptom, a beverage for improving skin symptom, a drug for improving skin symptom, and a medicine that is safe even when taken orally An object of the present invention is to provide a skin cosmetic that is safe to apply to the skin and has an excellent effect on improving skin symptoms.

  In order to solve the above-mentioned problems, the present inventors have conducted extensive research on a safe plant having a skin symptom-improving action. As a result, it has been found that an extract from Cimicifuga racemosa is effective. The headline and the present invention were completed.

The present invention is summarized as follows.
(1) A skin symptom improving agent comprising a Cimicifuga racemosa extract as an active ingredient.
(2) A supplement for improving skin symptoms, characterized by blending Cimicifuga racemosa extract.
(3) A food for improving skin symptoms, characterized by containing an extract of Cimicifuga racemosa.
(4) A skin symptom-improving drink characterized by containing an extract of Cimicifuga racemosa.
(5) A skin cosmetic characterized by containing an extract of Cimicifuga racemosa.
(6) A medicament for improving skin symptoms, comprising an extract of Cimicifuga racemosa as an active ingredient.

  The skin symptom improving agent of the present invention contains a Cimicifuga racemosa extract as an active ingredient, so that it has high safety and exhibits an excellent skin symptom improving action.

  In addition, the skin symptom improving supplement, the skin symptom improving food and the skin symptom improving beverage of the present invention are safe even when taken orally and improve the skin symptom by incorporating the Cimicifuga racemosa extract. be able to.

  The skin cosmetic of the present invention can be safely applied and improved on skin symptoms even when applied to the skin by blending Cimicifuga racemosa extract.

  Furthermore, the medicament for improving skin symptoms according to the present invention contains a Cimicifuga racemosa extract as an active ingredient, which is highly safe and can effectively prevent or improve the deterioration of skin symptoms. .

  The skin symptom improving agent of the present invention is characterized by containing an extract of Cimicifuga racemosa as an active ingredient.

  The Cimicifuga racemosa extract may be an extract obtained from Cimicifuga racemosa as a raw material for extraction, as well as a diluted solution or a concentrated solution of the extract. Moreover, the dried material which dried the extract with the well-known means may be sufficient.

  Cimicifuga racemosa, which is the raw material for extraction, is a plant belonging to the genus Sarcophaceae, commonly known as Black Kohosh. Simicifuga racemosa has long been eaten by North American Indians for the purpose of pain relief and improvement of menopause, and is still distributed in Europe and America as an edible herb. Shimisifugin, one of the components of Cimicifuga racemosa, is known to suppress the rapid decrease of estrogen and relieve symptoms of menopause. For the use of Cimicifuga racemosa extract, the treatment and / or prevention of cardiovascular disease, atherosclerosis, osteoporosis, dysmenorrhea or premenstrual syndrome and climacteric disorders, for example prevention of transient heat sensation Or it is disclosed as an estrogen type period selective drug for reduction (Japanese Patent Publication No. 2002-506827). Further, a composition containing an extract of Cimicifuga racemosa for improving various symptoms of premenstrual syndrome including skin roughness and menopause is disclosed (JP 2004-262922 A, JP 2004-2335 A). Issue gazette). However, there is no mention of the effect of improving skin symptoms in healthy people.

  The extraction site of Cimicifuga racemosa, which is the raw material for extraction, is not particularly limited, but a rhizome with a high content of triterpene glycosides is preferable.

  The extraction method is not particularly limited, and examples thereof include a solvent extraction method using an extraction solvent and a supercritical extraction method.

  Examples of the solvent used in the solvent extraction method include water, a hydrophilic solvent, and a mixture thereof.

  In the solvent extraction method, water used for the extraction solvent is not particularly limited, and examples thereof include tap water, distilled water, pure water, and ion exchange water.

  Examples of the hydrophilic solvent used as the extraction solvent in the solvent extraction method include lower alcohols such as methanol, ethanol, propyl alcohol, and isopropyl alcohol, lower aliphatic ketones such as acetone and methyl ethyl ketone, 1,3-butylene glycol, and propylene glycol. And polyhydric alcohols such as glycerin.

  As the mixed solvent in the solvent extraction method, water and a hydrophilic solvent are appropriately mixed and used. For example, a 50% ethanol solution is preferable because triterpene glycosides can be efficiently extracted.

  In the case of extraction by a solvent extraction method, for example, after drying the rhizome part of Cimicifuga racemosa as an extraction raw material, it may be subjected to extraction treatment with an extraction solvent as it is or after pulverization. Extraction may be performed at room temperature or under heating.

  The supercritical extraction method is an extraction method that uses a carbon dioxide fluid in a supercritical state at 31 ° C. and 7.4 MPa or more, and can extract effective components efficiently at a low temperature.

  The skin symptoms that are prevented or improved by the skin condition improving agent of the present invention are “moist feeling”, “freshness”, “tackiness”, “make-up feeling”, “smoothness”, “dullness” ”,“ Spots ”,“ wrinkles ”,“ transparency ”,“ pimple ”,“ skin hardness ”,“ skin texture ”,“ tension / elasticity ”,“ stickiness ”, and the like.

  In order to use the skin symptom improving agent as a supplement, it may be formulated by a known method. The dosage form when the skin symptom improving agent of the present invention is used as a supplement is not particularly limited, but for example, solid preparations such as tablets, powders, fine granules, granules, capsules, pills, liquid preparations, suspensions, Oral administration agents such as syrups and liquids such as emulsions may be mentioned. This orally administered agent includes excipients, disintegrants, binders, lubricants, surfactants, alcohols, water, water-soluble polymers, sweeteners, flavoring agents, It can be produced by a commonly used method by adding a sour agent, a pharmaceutical carrier and the like.

  In order to ingest the skin symptom-improving agent as a supplement, 0.3 to 200 mg per adult may be ingested as a dry weight of Cimicifuga racemosa extract.

  A skin symptom-improving beverage can be produced by blending a Cimicifuga racemosa extract into a beverage. Examples of the beverage include fruit juice, vegetable juice, barley tea, green tea, black tea, coffee, yogurt beverage, lactic acid bacteria beverage, and low alcohol beverage. By drinking a beverage containing Cimicifuga racemosa extract, the above skin symptoms can be safely prevented or improved.

Moreover, the food for skin symptom improvement can be manufactured by mix | blending a Cimicifuga racemosa extract with a foodstuff. Examples of the food include dairy products such as fermented milk, cheese, and butter, confectionery such as rice cake, cookies, chewing gum, and butter cake, and breads. By eating foods containing Cimicifuga racemosa extract, the above skin symptoms can be safely prevented or improved.

  Furthermore, skin cosmetics can be manufactured by mix | blending a Cimicifuga racemosa extract. Examples of skin cosmetics include skin lotion, milky lotion, cosmetic cream, foundation, blusher, and white powder. The skin cosmetic may be prepared according to a conventional method. By using a skin cosmetic containing a Cimicifuga racemosa extract, the above-mentioned skin symptoms are prevented or improved. Cimicifuga racemosa extract is a natural ingredient and is safe to apply to the skin.

  Furthermore, a skin symptom-improving medicament comprising the Cimicifuga racemosa extract as an active ingredient can be produced. The dosage form of the pharmaceutical agent for improving skin symptoms of the present invention is not particularly limited, but for example, solid preparations such as tablets, powders, fine granules, granules, capsules, pills, solutions, suspensions, syrups, emulsions Oral administration agents such as liquids. This orally administered agent includes excipients, disintegrants, binders, lubricants, surfactants, alcohols, water, water-soluble polymers, sweeteners, flavoring agents, It can be produced by a commonly used method by adding a sour agent, a pharmaceutical carrier and the like. The above-mentioned skin symptom is prevented or ameliorated by taking a skin symptom-improving medicine comprising a Cimicifuga racemosa extract as an active ingredient. The dosage of the skin symptom-improving drug may be 0.3 to 200 mg of Cimicifuga racemosa extract in dry weight per adult.

(Production Example 1)
5.2 kg of rhizome of Cimicifuga racemosa was extracted with 10 L of 50% aqueous ethanol, concentrated under reduced pressure and dried to obtain 445 g of extract.

  The sensory test was conducted to examine the effect of Cimicifuga racemosa extract on improving skin symptoms.

  Capsules filled with lactose were used as placebos, and capsules filled with Cimicifuga racemosa extract powder obtained in Production Example 1 were used as test articles.

  A panel of 21 women in their 20s and 30s who are healthy, 10 placebo groups that took placebo (Group a), and the Shimifuga extract group that took Cimicifuga racemosa extract (Group b) ) Was 11 persons.

  The shimifuga extract was taken at 200 mg / day, once daily, for 28 days after breakfast. In both the placebo group and the Shimifuga group, overdrinking and overeating were avoided during the period, and intake of commercial supplements was refrained.

  A sensory test was performed in a double-blind parallel two-group comparative test. The test substance was continuously ingested every morning for 28 days from the intake start date (Monday). A questionnaire (see FIG. 1) was conducted on every intake day and every Wednesday and Saturday during the intake period. The results are shown in FIGS.

  In the morning skin impression of `` moist feeling '', `` freshness '', and `` stickiness '', a significant score improvement was confirmed before and after ingestion of the Shimisifuga extract group (Group b), but the placebo group (Group a) ) Was not confirmed. Furthermore, regarding “moist feeling”, the value of the Shimisifuga extract group (group b) on the last intake day was significantly improved compared to the placebo group (group a).

  Compared with pre-ingestion in the Shimifuga extract group (Group b) in the skin changes over time of “skininess”, “pores”, “pimples”, “skinness”, “skin texture”, and “stickiness” Although significant score improvement was confirmed, no change was observed in the placebo group (group a). Furthermore, with regard to “Katsutsuki” and “Smooth”, the value of the Shimifuga extract group (Group b) after the 20th day of ingestion was significantly improved compared to the placebo group (Group a).

  The skin symptom improving agent of the present invention, supplements containing the same, foods, beverages and medicines contain a Cimicifuga racemosa extract as an active ingredient, which is highly safe and exhibits an excellent skin symptom improving action. Is extremely useful.

questionnaire. A graph showing the change over time of one month of the average values of the questionnaires of “feel of the whole face”, “moist feeling”, and “freshness”, and the horizontal axis shows the number of days. A graph showing the change over time of one month in the average value of the questionnaire of “stickiness” and “makeup paste”, and the horizontal axis shows the number of days. A graph showing the change over time of one month of the average value of the questionnaire for “feeling of bulkiness”, “dullness”, and “pores”, and the horizontal axis indicates the number of days. A graph showing the change over time of one month of the average value of the questionnaire for “spots and freckles”, “wrinkles”, and “transparency”, and the horizontal axis indicates the number of days. A graph showing the changes over time of one month of the average values of the questionnaires of “pimples”, “skin softness”, and “skin texture”, and the horizontal axis indicates the number of days. A graph showing the change over time of one month of the average value of the questionnaire of “tension / elasticity” and “stickiness”, and the horizontal axis shows the number of days.

Claims (6)

A skin symptom improving agent characterized by containing an extract of Cimicifuga racemosa as an active ingredient. A skin symptom improvement supplement characterized by containing Cimicifuga racemosa extract. A skin symptom-improving food characterized by containing an extract of Cimicifuga racemosa. A skin symptom-improving beverage characterized by containing an extract of Cimicifuga racemosa. A skin cosmetic characterized by containing an extract of Cimicifuga racemosa. A medicament for improving skin symptoms, comprising an extract of Cimicifuga racemosa as an active ingredient.

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