KR20200074104A - 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 - Google Patents
표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 Download PDFInfo
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- KR20200074104A KR20200074104A KR1020207010211A KR20207010211A KR20200074104A KR 20200074104 A KR20200074104 A KR 20200074104A KR 1020207010211 A KR1020207010211 A KR 1020207010211A KR 20207010211 A KR20207010211 A KR 20207010211A KR 20200074104 A KR20200074104 A KR 20200074104A
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- RTMQIRDUBCMDSV-RXMQYKEDSA-N CCC[C@@H](C)C(F)(F)F Chemical compound CCC[C@@H](C)C(F)(F)F RTMQIRDUBCMDSV-RXMQYKEDSA-N 0.000 description 1
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
- C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
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- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04005—Cytidine deaminase (3.5.4.5)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020257014587A KR20250068785A (ko) | 2017-10-04 | 2018-10-04 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568313P | 2017-10-04 | 2017-10-04 | |
| US62/568,313 | 2017-10-04 | ||
| PCT/US2018/054469 WO2019071048A1 (en) | 2017-10-04 | 2018-10-04 | SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257014587A Division KR20250068785A (ko) | 2017-10-04 | 2018-10-04 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200074104A true KR20200074104A (ko) | 2020-06-24 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207010211A Pending KR20200074104A (ko) | 2017-10-04 | 2018-10-04 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
| KR1020257014587A Pending KR20250068785A (ko) | 2017-10-04 | 2018-10-04 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257014587A Pending KR20250068785A (ko) | 2017-10-04 | 2018-10-04 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12221636B2 (enExample) |
| EP (1) | EP3692145A4 (enExample) |
| JP (2) | JP2020537516A (enExample) |
| KR (2) | KR20200074104A (enExample) |
| CN (1) | CN111727247A (enExample) |
| AU (2) | AU2018346527B2 (enExample) |
| CA (1) | CA3077086A1 (enExample) |
| WO (1) | WO2019071048A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220077054A (ko) * | 2020-12-01 | 2022-06-08 | 한양대학교 산학협력단 | 티민-사이토신 서열 특이적 사이토신 교정 활성이 증진된 아데닌 염기교정 유전자가위 및 이의 용도 |
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| WO2019084062A1 (en) * | 2017-10-23 | 2019-05-02 | The Broad Institute, Inc. | SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220077054A (ko) * | 2020-12-01 | 2022-06-08 | 한양대학교 산학협력단 | 티민-사이토신 서열 특이적 사이토신 교정 활성이 증진된 아데닌 염기교정 유전자가위 및 이의 용도 |
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