KR20200055770A - Napi2b 표적 요법에 대한 반응을 예측하기 위한 조성물 및 방법 - Google Patents

Napi2b 표적 요법에 대한 반응을 예측하기 위한 조성물 및 방법 Download PDF

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Publication number
KR20200055770A
KR20200055770A KR1020207011297A KR20207011297A KR20200055770A KR 20200055770 A KR20200055770 A KR 20200055770A KR 1020207011297 A KR1020207011297 A KR 1020207011297A KR 20207011297 A KR20207011297 A KR 20207011297A KR 20200055770 A KR20200055770 A KR 20200055770A
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South Korea
Prior art keywords
napi2b
antibody
cancer
amino acid
seq
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Abandoned
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KR1020207011297A
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English (en)
Korean (ko)
Inventor
레베카 모셔
로라 엘 폴링
도날드 에이 버그스트롬
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메르사나 테라퓨틱스, 인코포레이티드
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Publication of KR20200055770A publication Critical patent/KR20200055770A/ko
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G01N33/57423—
    • G01N33/57449—
    • G01N33/57492—
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
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  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
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  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
KR1020207011297A 2017-09-20 2018-09-20 Napi2b 표적 요법에 대한 반응을 예측하기 위한 조성물 및 방법 Abandoned KR20200055770A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762561107P 2017-09-20 2017-09-20
US62/561,107 2017-09-20
US201762571397P 2017-10-12 2017-10-12
US62/571,397 2017-10-12
US201862718692P 2018-08-14 2018-08-14
US62/718,692 2018-08-14
PCT/US2018/051951 WO2019060542A2 (en) 2017-09-20 2018-09-20 COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE TO NAPI2B TARGETING THERAPY

Publications (1)

Publication Number Publication Date
KR20200055770A true KR20200055770A (ko) 2020-05-21

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Application Number Title Priority Date Filing Date
KR1020207011297A Abandoned KR20200055770A (ko) 2017-09-20 2018-09-20 Napi2b 표적 요법에 대한 반응을 예측하기 위한 조성물 및 방법

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Country Link
US (2) US11596694B2 (https=)
EP (1) EP3685166A2 (https=)
JP (1) JP7279026B2 (https=)
KR (1) KR20200055770A (https=)
CN (1) CN111492246A (https=)
AU (1) AU2018337947A1 (https=)
BR (1) BR112020005390A2 (https=)
CA (1) CA3075798A1 (https=)
IL (1) IL273252B2 (https=)
MX (1) MX2020003214A (https=)
TW (1) TW201929906A (https=)
WO (1) WO2019060542A2 (https=)

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CA3149482A1 (en) 2019-08-02 2021-02-11 Mersana Therapeutics, Inc. Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer
CN114641316A (zh) 2019-10-30 2022-06-17 Cis制药股份公司 用于递送活性剂的生物相容性聚合物药物载体
IL294321B1 (en) 2020-01-09 2026-04-01 Mersana Therapeutics Inc Antibody-drug conjugates are attached at a specific site with linkers that include peptides.
WO2021202984A1 (en) 2020-04-02 2021-10-07 Mersana Therapeutics, Inc. Antibody drug conjugates comprising sting agonists
WO2022032228A1 (en) 2020-08-07 2022-02-10 The Broad Institute, Inc. Therapeutic targeting of phosphate dysregulation in cancer via the xpr1:kidins220 protein complex
JP7589759B2 (ja) * 2021-02-08 2024-11-26 株式会社島津製作所 推定装置
EP4605426A1 (en) * 2022-10-19 2025-08-27 Zymeworks BC Inc. Antibody-drug conjugates targeting napi2b and methods of use
CA3266931A1 (en) * 2022-10-19 2024-04-25 Zymeworks Bc Inc. ANTI-NAPI2B ANTIBODIES AND METHODS OF USE
TW202530268A (zh) * 2023-10-19 2025-08-01 加拿大商酵活英屬哥倫比亞有限公司 抗ｎａｐｉ２ｂ抗體－藥物結合物及使用方法
WO2025199352A2 (en) * 2024-03-20 2025-09-25 Juno Therapeutics, Inc. Antibodies specific for solute carrier family 34 member 2 (slc34a2)

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