KR20200048687A - Melting Patch and Method of producing the same - Google Patents

Abstract

The present invention relates to a biocompatible patch which completely melts upon contact with the skin. An object of the present invention is to provide a melting patch which completely melts upon contact with the skin to remove the hassle of discarding a support in an existing patch, can absorb all skin active ingredients into the skin without being wasted, and also can be directly adhered to the skin without forming a separate adhesive layer.

Description

Melting patch and method of producing the same

The present invention relates to a biocompatible patch that completely melts upon contact with the skin.

Human skin undergoes changes by various internal and external factors as it ages. Accordingly, as a whole, wrinkles of the skin increase, skin elasticity decreases, and spots, freckles, and blotch increase, causing various changes.

Accordingly, various cosmetics that prevent and improve the skin damage or aging phenomenon have been developed and used, and among these, a pack formulation, etc., is a formulation for continuously applying and attaching the active ingredient to the skin.

These packs are products that apply the skin active ingredient to the skin in a gel form or wet the powder of the active ingredient and apply it to the skin to dry and remove it after a period of time. However, these conventional products have a problem of washing hands after applying to the skin, and there is a problem of maximally suppressing skin movement until it is dried on the skin surface or removed after drying.

On the other hand, there is a cosmetic formulation of a patch formulation to place the skin active ingredient and the adhesive component on the support and attach it to the skin. For example, there is a method of making a patch by infiltrating the adhesive component and the skin active component on the nonwoven fabric, and then attaching it to the skin. However, such a patch has a problem in that the support must be removed and discarded after a certain period of time after being attached to the skin, and skin active ingredients that always remain on the support are discarded together with the support.

The object of the present invention is to completely dissolve upon contact with the skin, while removing the hassle of discarding the support in the conventional patch, all of the skin active ingredients can be absorbed into the skin without being wasted, and without forming a separate adhesive layer. It is also to provide a melting patch that can be directly adhered to the skin.

It is also an object of the present invention to provide a melting patch that can be completely dissolved upon contact with the skin and a method of manufacturing the same.

In order to achieve the object of the present invention, the present invention, 10 to 35% by weight of the active ingredient; Hyaluronic acid 50-75 wt%; And 5 to 15% by weight of water or organic solvent; provides a melting patch comprising a.

In order to achieve another object of the present invention, the present invention is a method of manufacturing a melting patch, and a first step of dissolving 0.1 to 5% by weight of the active ingredient in 65 to 90% by weight of water or an organic solvent; A second step of dissolving 5 to 20% by weight of hyaluronic acid in the mixture of the first step; A third step of naturally degassing the mixture of the second step; A fourth step of applying the solution of the third step on a substrate; And a fifth step of drying the composition of the melting patch such that 10 to 35% by weight of the active ingredient, 50 to 75% by weight of hyaluronic acid, and 5 to 15% by weight of water or an organic solvent are prepared. Provide a method.

Since the melt patch according to the present invention is configured without a separate support, there is no hassle of removing the support after a certain period of time after adhering to the skin, and it is also environmentally friendly because it can reduce the discarded support, and Since all of them can be absorbed into the skin without any active ingredients that are left on the support and discarded, it is possible to obtain an excellent skin improvement effect compared to other patches containing the same content of the active ingredients.

In addition, it is possible to manufacture a melting patch that completely dissolves by a simple process, resulting in a reduction in cost.

1 schematically shows a process for manufacturing a melting patch according to an embodiment of the present invention.
2 shows a thin film coating process in more detail according to an embodiment of the present invention.

The present invention will be described in more detail below. However, this is intended to explain the present invention in more detail, and the scope of the present invention should not be limited thereby.

<Melting patch>

Melting patch according to an embodiment of the present invention is 10 to 35% by weight of the active ingredient; Hyaluronic acid 50-75 wt%; 5 to 15% by weight of water or an organic solvent.

As used herein, the term “melting patch” refers to a patch that can be completely dissolved and absorbed into the skin after a certain period of time upon contact with the skin.

As used herein, the term "active ingredient (skin active ingredient)" is a small molecular weight compound (chemical compound), a protein, an antibody, an active substance, a vaccine, a cosmetic ingredient, and the like for pharmaceutical, medical, or cosmetic use. It can be any substance, improves the affinity with the skin, and plays a role in increasing the skin absorption rate of functional ingredients that can effectively act on the skin, whitening ingredients, wrinkle improvement ingredients, nutrition ingredients, moisturizing ingredients, soothing ingredients And one or two or more selected from the group consisting of trouble improving components.

Specifically, as whitening and wrinkle improvement components, for example, chaga extract, licorice root extract, horse riding (Cimicifuga heracleifolia Komarov) extract, sewage extract, black sesame extract, circumcision mushroom extract, Angelica extract, epithelium extract, peony extract, There are extracts of ginseng, golden extract, tree of megosticum (piper methysticum), arbutin, niacinamide, vitamin C derivatives, ascorbyl glucoside, astetraisopalmitate, alpha-bisabolol.

The vitamin C derivative may be any of derivatives having substantially the same activity as vitamin C, and such derivatives are very well known in the art, for example, ethyl ascorbyl ether.

Wrinkle improving ingredients include adenosine, retinol, retinyl palmitate, and polyethoxylated retinamide.

Nutritional and moisturizing ingredients include collagen, polyglutamic acid, beta-glucan, and placental protein.

Effective ingredients for improving soothing and trouble include arginine, ceramide, pseudoceramide, caffeoyl tripeptide-1, aloe extract, allantoin, lavender flower extract, bergamot leaf extract, peppermint leaf extract, freesia flower extract, Rosemary leaf extract, and chamomile flower / leaf extract.

Antioxidants include Tocopheryl Acetate, Butylated Hydroxy Toluene, Totarol, Ubiquinone, Kojic Acid, and the like.

As a moisturizing component, diglycerin solbitol, sodium hyaluronate, POE methylglucoside or glycerine may be used.

Emulsions include squalane, liquid paraffin, olive oil, camellia Japonica Seed Oil, Macadamia Integrifolia Seed Oil, caprylic / capriglyceride / Capric Glycerides), and caster oil.

Nutrient components include allantoin, DL-panthenol, trehalose, allantoin, dipotassium glycyrrhizate, betaine, panthenol, Rose Canina Fruit Oil, Coconut Oil (Cocos Nucifera (Coconut) Oil), Phytosterols, Hydrolyzed Collagen, Acetyl Hexapeptide-1, Acetyl Hexa Peptide-8 (Acetyl Hexapeptide-8), palmitoyl pentapeptide-5 (Palmitoyl Pentapeptide-5), copper tripeptide-1 (CopperTripeptide-1) and the like.

Baobab Seed Oil is derived from the seeds of the Baobab tree native to East Africa and South Africa. African women have applied baobab oil to protect their skin in the harsh savannah environment. Baobab oil is rich in vitamins A, D, and E, which is rich in linoleic acid that is not produced by the human body, and helps moisturize the skin, regenerate skin cells, and maintain the elasticity and softness of the skin.

Ceramides include Ceramide NP, Ceramide NS, Ceramide Ace, Ceramide IOP, and Ceramide AP.

In addition, the active ingredient may include polydeoxyribonucleotide (PDRN). PDRN is known as a tissue regeneration material and can be made from DNA extracted from salmon semen. When PDRN is used by mixing glutathione and hyaluronic acid, it can be solved from the base layer of the skin to strengthening elasticity, moisturizing moisture and whitening all at once.

The active ingredient is preferably 10 to 35% by weight of the total composition of the melting patch, preferably 15 to 35% by weight. If the active ingredient is contained less than 10% by weight, the desired useful effect cannot be obtained, and if it exceeds 35% by weight, it may affect the stability of the melting patch.

As a solvent, water or an organic solvent may be used, and the water is preferably purified water, and is 5 to 15% by weight, preferably 8 to 15% by weight of the total composition of the melting patch. If the content of water exceeds 15% by weight, the gel-like patch structure may collapse, and if less than 5% by weight is included, the skin adhesion is poor and the patch may crack.

The organic solvent can be any organic solvent that can be applied to cosmetics, and can be appropriately selected by a person skilled in the art.

The hyaluronic acid is included in 50 to 75% by weight of the total composition of the melting patch, more preferably 50 to 70% by weight. If the content of hyaluronic acid is less than 50% by weight, the stability and skin adhesion of the melted patch is poor, and if it is more than 75% by weight, the patch structure may collapse.

The molecular weight of the hyaluronic acid is preferably 50 kDa to 150 kDa (50,000 to 150,000 Da). If the molecular weight of hyaluronic acid is less than 50 kDa, it is possible that the desired active ingredient cannot be loaded and proper moisture loading, which has an important effect on patch formation, is not possible because a large amount of hyaluronic acid is required up to the optimum coatable viscosity. If it is large, even a small amount of hyaluronic acid content reaches a certain viscosity that can be blended to dry out in the drying step or it cannot be recovered.

According to one embodiment of the present invention, the thickness of the melting patch is 10 to 50㎛, preferably 20 to 40㎛. If the thickness of the melting patch is less than 10 µm, it is easy to tear, and if it is thicker than 50 µm, skin adhesion may be deteriorated, or skin absorption may be excessively slow due to unnecessary excessive components.

For convenience in storage, transportation, etc., the melting patch may further attach a protective film to at least one side of the melting patch.

The protective film can be used as long as it is conventionally used in the art, and when used, it should be removed before use. For example, an impermeable polymer film may be used.

<Melting patch manufacturing method>

Melting patch according to the present invention is a first step of dissolving by adding 0.1 to 5% by weight of the active ingredient in 65 to 90% by weight of water; A second step of dissolving 5 to 20% by weight of hyaluronic acid in the mixture of the first step; A third step of naturally degassing the mixture of the second step; A fourth step of applying the solution of the third step on a substrate; And a fifth step of drying the composition of the melting patch such that 10 to 35% by weight of the active ingredient, 50 to 75% by weight of hyaluronic acid, and 5 to 15% by weight of water or an organic solvent.

According to an embodiment of the present invention, in the first step, the active ingredient may be added to the water and mixed at 300 to 600 rpm / 20 to 25 min.

According to an embodiment of the present invention, in the second step, hyaluronic acid is quantitatively introduced into the mixture of the water and the active ingredient, and a wet process is performed. Here, the soaking process means a process in which hyaluronic acid naturally contains water without applying external force such as dispensing at the initial stage when hyaluronic acid and purified water meet to prevent powdery flying of polymer hyaluronic acid and facilitate dissolution.

This is to prevent the powder of hyaluronic acid from being blown and to obtain optimal dissolution. The hyaluronic acid is mixed at 200-2,000 rpm for 40-90 minutes.

According to an embodiment of the present invention, the third step is a step of defoaming after mixing all the components. Degassing processes known in the art can be used. According to one embodiment of the present invention, the defoaming is performed at a temperature of 20 to 30 ° C for 12 to 36 hours.

According to an embodiment of the present invention, the fourth step is a step of applying the mixture of the third step on a substrate. At this time, the final patch is coated to have a thickness of 10 to 50 µm.

의 온도, 20~40분 동안 행해질 수도 있다.According to one embodiment of the present invention, the fifth step is performed at a temperature of 20 to 25 ° C and a humidity of 30 to 40% for 24 to 30 hours. The drying conditions can be easily adjusted by a person skilled in the art so that the composition of the final melting patch is 10 to 35% by weight of the active ingredient, 50 to 80% by weight of hyaluronic acid, and 5 to 15% by weight of water (or solvent). have. Or, the fifth stage is 70 ~ 90

Temperature, may be done for 20-40 minutes.

According to an embodiment of the present invention, after the fifth step may further include the step of attaching the protective film. The protective film can protect the patch from contamination during storage and transportation. The protective film can be attached to both sides of the patch.

According to an embodiment of the present invention, further comprising the step of punching into a desired shape after contact with the protective film. Specifically, in the case of a melting patch for improving the wrinkles around the eye, it is punched into the shape under the eye, in the case of a melting patch for improving the wrinkles in the shape of an arm, and in the case of a whitening melting patch for the entire face, in a whole face shape Can shed. When punching, the shape of the patch can be appropriately modified by a person skilled in the art depending on the application.

In addition, in the mixing step of the active ingredient and / or hyaluronic acid, a color extract may be further added to display different colors of the final melting patch according to the type of the active ingredient included. That is, in the case of a patch containing a vitamin C derivative as an active ingredient, a yellow colored extract is added to increase the gloss, and in the case of a patch containing 70% or more of hyaluronic acid, a blue colored extract is included in the patch, and elasticity is enhanced by including PDRN. The height of the patch contains a red colored extract, so it is easy to understand what kind of functionality it has by only the appearance of the melting patch.

The melted patch prepared in this way can be used after washing the face with a toner and then removing the patch and attaching it to the desired area (eye area, under the eyes, wrinkles, mouth area, etc.) depending on the function of the patch. After a certain period of time, the melting patch dissolves according to body temperature, and when it is changed into a highly concentrated essence, it can be absorbed moistly throughout the face.

More preferably, after attaching the melting patch to the desired area, the general mask pack is covered on the skin, and after 15-20 minutes, the mask pack is removed to melt the melted patch in contact with the skin and turn into a highly concentrated essence. Can be absorbed.

Hereinafter, the present invention will be described in more detail through specific examples. However, this is only an example for specifically describing the present invention, and is not intended to limit the scope of the present invention.

<Examples and Comparative Examples>

The active ingredients were added to the purified water weighed according to Table 1 below (initial content), mixed at 300 to 600 rpm / 20 to 25 min, and then hyaluronic acid was weighed and put in and soaked. Hyaluronic acid was dissolved at a dispermix of 500 to 1,000 / 30 min, and after complete dissolution, defoaming was performed at 25 ° C. for 10 hours to completely remove air bubbles.

The defoamed mixed solution was applied to a glass substrate at 400 to 500 μm, and dried at 25 ° C. and 35% humidity for 24 to 30 hours to obtain a patch of 20 to 40 μm (final content).

Experimental Example: Film Formation Measurement Method

The compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were prepared according to the compositions of Tables 1 and 2, and then defoamed and aged at 20 ° C to 25 ° C for 24 to 30 hours, followed by thin film coating on a glass plate.

It was dried for 24 to 30 hours at a temperature of 30 to 35% humidity and 20 to 25 ° C.

The films thus prepared were evaluated according to the evaluation criteria in Tables 3 to 6 below.

(Unit: weight%) Ingredient name Molecular Weight Example 1 Example 2 Example 3 Early final Early final Early final HA 10,000 100,000 10 69.29 8 52.74 11 66.00 200,000 One 6.00 1 million 0.2 1.39 0.5 3.30 15.02 Active ingredient (API) 2.5 17.32 5 32.96 2.5 15.00 Other 0 water 87.3 12 86.5 11 85.5 13 gun 100 100 100

(Unit: weight%) Molecular Weight Comparative Example 1 Comparative Example 2 Comparative Example 3 Early final Early final Early final HA 10,000 100,000 15 88.00 5 43.50 14 87.75 200,000 5 43.50 1 million 0.2 1.25 Active ingredient (API) Other water 85 12 90 13 85.8 11 total 100 100 100

(Unit: weight%) evaluation Delamination Banding condition A 100% peeling No banding B 90% or more peeling below 10 C 80% or more 20% or less D 70% or more 30% or less E 60% or more 40% or less

Experimental Example 2: Solubility, residue after dissolution, and essence measurement method

Melting patches prepared in Examples and Comparative Examples were cut into width x length = 4 cm x 1.5 cm. Each cut and melted patch was attached to the skin (wide area inside the forearm). The hydrogel mask (product name: Velatena Hydrogel Hyaluronic Acid Mask / manufacturer and manufacturer: Dongbang Medical Co., Ltd.) was cut into width x length = 8 cm x 4 cm, and the cut hydrogel mask was compared with Examples. The melted patch prepared in the example is attached to be completely covered.

Solubility was limited to each time on the basis of complete dissolution.

After dissolution, the residue standards were visually confirmed.

For the essence (moisture), a skin moisture meter (SPO ENTA SCAN: Product Certification No. MSIP-CRM-SPO-SSM100) was used, and the measurement conditions were measured after 20 minutes of skin absorption after complete dissolution. Each evaluation is an average of the results obtained by randomly selecting 20 women in their 20s and 40s.

Evaluation criteria are shown in Tables 4 to 6 below. The measurement results are shown in Table 7.

Solubility standard evaluation standard A Within 15 minutes B 16-20 minutes C 21-25 minutes D 26-30 minutes E 31 minutes or more

Based on residue after dissolution evaluation standard A No residue / Excellent spreadability B No residue / spreadability C Residual slipping / poor spreadability D Residue pushing / clumping E Debris push / fall off

Essence (moisture) standard evaluation Moisture measurement value A 70% or more B 60 ~ 69% C 50 ~ 59% D 40-49% E 30 ~ 39%

Evaluation items Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Film formation A B A A B A Solubility A B B C B C Residue after dissolution B A B C C C Essence A A B C C C

As can be seen from Table 7, the melted patch produced according to the present invention has excellent film formation and high solubility when it comes into contact with the skin, and has high absorption so that there is no residue after dissolution. However, in the case of a patch deviating from the configuration of the present invention, there was a problem in that the film formation was low or the solubility was low, so adhesion was difficult, or after the attachment, dissolution did not occur well, leaving a residual feeling.

Claims (12)

10 to 35% by weight of the active ingredient;
Hyaluronic acid 50-75 wt%; And
Characterized in that it comprises 5 to 15% by weight of water or organic solvent;
Melting patch. According to claim 1,
Melting patch characterized in that the active ingredient is 10 to 35% by weight, hyaluronic acid is 50 to 70% by weight, and water or an organic solvent is 8 to 15% by weight. According to claim 1,
Melting patch, characterized in that the thickness of the melting patch is 20 ~ 40㎛. The melting patch according to claim 1, wherein the active ingredient is at least one selected from the group consisting of whitening ingredients, wrinkle improving ingredients, nutrient ingredients, moisturizing ingredients, soothing ingredients and trouble improving ingredients. The method of claim 1
Chaga Mushroom Extract, Licorice Root Extract, Horsetail (Cimicifuga heracleifolia Komarov) Extract, Sewage Extract, Black Sesame Extract, Phellinus Linteus Extract, Angelica Extract, Sangbaekpi Extract, Peony Extract, Ginseng Extract, Golden Extract, Piper methysticum Tree Extract , Arbutin, niacinamide, vitamin C derivative, ascorbylglucoside, astetraisopalmitate, alpha-bisabolol adenosine, retinol, retinyl palmitate, polyethoxylated retin Polyethoxylated Retinamide Collagen, polyglutamic acid, beta glucan, and placental protein arginine, ceramide, pseudoceramide, caffeoyl tripeptide-1, aloe extract, allantoin, lavender flower extract, bergamot Leaf extract, peppermint leaf extract, freesia flower extract, rosemary leaf extract, and camo Flower / leaf extract, Tocopheryl Acetate, Butylated Hydroxy Toluene, Totarol, Ubiquinone, Kojic Acid, Diglycerin Solbitol (solbitol), sodium hyaluronate, POE methylglucoside or glycerine, squalane, liquid paraffin, olive oil, camellia japonica Seed Oil, Macadamia Integrifolia Seed Oil, Caprylic / Capric Glycerides, Caster Oil, Allantoin, DL-panthenol, Trehalose, Allantoin, Dipotassium Glycyrrhizate, Betaine, Panthenol, Rose Canina Fruit Oil, Cocos Nucifera (Coconut) Oil), Phytosterol sterols), Hydrolyzed Collagen, Acetyl Hexapeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-5, Melting patch characterized by at least one selected from the group consisting of Copper Tripeptide-1, Baobab Seed Oil, and PDRN (polydeoxyribonucleotide). According to claim 1,
Melting patch, characterized in that the molecular weight of the hyaluronic acid is 50kDa ~ 150kDa. The method according to any one of claims 1 to 6,
A melting patch further comprising a protective film attached to at least one side of the melting patch. It is a manufacturing method of melting patch,
A first step of dissolving 0.1 to 5% by weight of the active ingredient in 65 to 90% by weight of water or an organic solvent; A second step of dissolving 5 to 20% by weight of hyaluronic acid in the mixture of the first step; A third step of naturally degassing the mixture of the second step; A fourth step of applying the solution of the third step on a substrate; And a fifth step of drying the composition of the melting patch such that 15 to 35% by weight of the active ingredient, 50 to 75% by weight of hyaluronic acid, and 5 to 15% by weight of water or an organic solvent are included. Method of manufacturing a melting patch. The method of claim 8,
The fifth step is a method of manufacturing a melting patch characterized in that it is performed for 24 to 30 hours at a temperature of 20 to 25 ° C and a humidity of 30 to 40%. The method of claim 8,
The manufacturing method of the melting patch, characterized in that the thickness of the melting patch after the fifth step is 20 ~ 40㎛. The method of claim 8,
After the first step, the method of manufacturing a melting patch, characterized in that it further comprises the step of soaking the hyaluronic acid. The method of claim 8,
The fifth step is 70-90

The temperature, the manufacturing method of the melting patch, characterized in that is performed for 20 to 40 minutes.

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