KR20090083750A - Skin dissolvable touch film - Google Patents

Abstract

A skin soluble touch film is provided to dip high content of active ingredient in needed site with concentrated and proper amount of ingredient. A skin soluble touch film which is dissolved by film resolving agent on the skin has applicable for on specific site and comprises: 100 weight part of touch film forming polymer; 0.1-50 weight part of gelling agent, 0.1-40 weight part of plasticizer; and 0.001-40 weight part% of active ingredient based on total weight of the touch film. The water content of the touch film is less than 50 weight% and thickness is 1-5,000um. The skin soluble touch film is resolved at 1~70‹C within 0.1~100 seconds. The skin soluble touch film (2) in which active ingredient is dipped is formed on a stripping film (1).

Description

Skin Soluble Touch Film {Skin Dissolvable Touch Film}

The present invention relates to a skin soluble touch film that is biologically or physiologically applicable. More specifically, the present invention, when applied to the skin, has an excellent surface active ability by skin secretion, skin temperature, moisture, dissolution aid and the like, and thus skin soluble touch film exhibiting excellent solubility, solubility and skin absorption of the active ingredient. It is about.

Many studies have been conducted on conventional skin and transdermal absorbent formulations. In particular, materials having a relatively low molecular weight are relatively well absorbed through the skin, and thus researches on transdermal absorbents of such low molecular weight materials have been actively conducted. Such formulations are used in cosmetic packs (mask packs), cataplasmas, pars, aerosols, lotions, ointments, creams and liquid forms. However, formulations that support such drugs have many disadvantages and problems. That is, in the formulation of the drug in liquid form, a support (eg, gauze in the form of a nonwoven fabric such as cotton) for supporting the active substance is used. However, such a support has inconveniences such as visual problems, fit, and skin troubles when applied to the skin, and increases the cost in terms of productivity. In addition, when attached to exposed areas (eg, face, etc.), they tend to hurt the aesthetics and avoid use, which makes them unsuitable for continuous drug delivery. Moreover, it is inconvenient to carry due to the use of a container that carries the drug, and when applied to the skin except for the support, the drug may contaminate clothing or the outside, and it is difficult to apply an appropriate amount to the proper site.

Conventional film formulations also do not quickly dissolve the active ingredients supported in the film formulations when applied to the skin, etc. In order to adhere to the skin should be used separately such as gauze, band-aid. Phaff formulations have a problem of deviating from the drug administration site, and may also cause skin problems.

Cosmetic packs containing functional materials are prepared by adding water or lotion to the nonwoven fabric and other supports, or by adding functional extracts, and the support such as nonwoven fabric becomes stiff when the makeup lotion or functional extract is added or has a bad feeling of use. have. Furthermore, protein materials such as natural or animal proteins such as collagen, silk, and fibroin proteins are difficult to handle due to the weak strength of the material itself and are sensitive to temperature, making it difficult to form gels at room temperature or by lyophilization. There is a problem that is an expensive product. The cosmetic pack form also has a disadvantage in that it takes a considerable time to dry after application and form a film, so it is difficult to sufficiently penetrate the cosmetic agent in the skin within a short time and must be removed. In addition, it causes inconvenience for the user to do other work immediately after application, and causes inconvenience to be removed. Moreover, liquid or cream products that are applied to the skin using hands or tools should be placed in containers such as tubes, bottles, and cans, making it inconvenient to carry and store. When it is applied to and applied to the application, it is difficult to properly control the amount of use, so overuse and underuse may occur due to overuse. In addition, functional substances effective on the skin added to the existing functional cosmetics are not only susceptible to moisture or light, but are easily decomposed and destroyed in the air. Such active substances and drugs that are vulnerable to moisture are difficult to manufacture, store, and manage, and therefore, there is a restriction in the preparation and use of such active substances and drugs in the transdermal or dermal absorbent type. Furthermore, there is a problem in that the addition of a high content of the active substance and drug brings about a change in phase separation or formulation.

It is an object of the present invention to provide a skin soluble touch film which is biologically or physiologically applicable.

Still another object of the present invention is to provide a skin-soluble touch film having excellent absorbency, solubility, solubility, adhesion, and adhesion to skin.

Another object of the present invention is to provide a skin-soluble touch film that is easy to formulate, store, manage or carry.

According to the invention,

(A) 100 parts by weight of the touch film-forming polymer material, (B) 0.1-50 parts by weight of the gelling agent, (C) 0.1-40 parts by weight of the plasticizer and the total weight of the skin-soluble touch film. It comprises a weight percent, provided a skin soluble touch film is dissolved by a film dissolving agent on the skin.

The skin soluble touch film of the present invention may be provided in an amount that can be intensively controllable in a desired amount of the active ingredient is supported by a large amount of the active ingredient. In addition, the skin soluble touch film of the present invention, when applied to the skin, the skin secretion, skin temperature, moisture, solubility of the active ingredient by the film dissolving agent, solubility and excellent absorbency, adhesion and adhesion to the skin, skin troubles and There is no fear of contamination other than the applied area. Furthermore, since it can be manufactured in any desired form, it can be manufactured in a convenient form according to the shape of the application site and can easily adjust the application amount.

Since the skin-soluble touch film of the present invention may be packed in a vacuum state, chemical reaction with moisture in the air is prevented until use, thereby preventing the change of the active substance. Therefore, it is easy to prevent the alteration of the product, and to formulate, store and manage the product, and is easy to carry. In addition, there is no problem in appearance. The skin soluble touch film of the present invention exhibits better solubility, solubility, and absorbency of the active ingredient when used in combination with a film dissolving agent.

According to the present invention, it is excellent in absorbency, solubility, solubility, adhesion and adhesion to the skin, and is easy and simple to formulate, store, manage or carry, and has no skin troubles and appearance problems, and contaminants other than the applied area. There is no concern, and there is provided a skin soluble touch film loaded with a high content of active material.

The term 'soluble' in the present invention means that when the skin-soluble touch film of the present invention is applied to the skin, the film is completely formed within 0.1 to 100 seconds at 1 to 70 ° C, preferably 1 to 50 ° C by human secretion and / or film dissolving agent. It means to dissolve.

The skin-soluble touch film of the present invention is maximized by adjusting the moisture content of the film to an appropriate amount, the amount of loading of the functional material (active ingredient) unstable and vulnerable to moisture. Furthermore, the film of the present invention not only can carry a large amount of functional material on the film by using a water-soluble polymer that is friendly to the human body, but also exhibits excellent solubility, solubility, and absorbency of the active ingredient when the film is applied to the skin. Hereinafter, the skin soluble touch film component of the present invention, the skin soluble touch film manufacturing method and the soluble touch film produced according to the present invention will be described in detail.

1. Skin Soluble Touch Film Components

The skin soluble touch film (hereinafter referred to as 'touch film') of the present invention comprises (A) a polymer material forming a film, (B) a gelling agent, (C) a plasticizer and (D) an active ingredient. Furthermore, the touch film of the present invention may further include (E) other additive components as optional components depending on the use and properties of the film.

(A) film-forming polymer material

The film forming polymer material (A) is a polymer material for forming a skin soluble touch film and supporting an active ingredient in the film, and is a main forming agent of the touch film.

Film-forming polymeric materials (A) that can be used in the films of the present invention are, but are not limited to, for example, pullulan, hydroxypropylmethyl cellulose (HPMC), hydroxymethyl cellulose (HMC), hydroxide Hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), methyl cellulose (MC), hydroxypropyl methyl cellulose phthalate (HPMCP), hydroxypropyl methyl cellulose acetsuccinate (HPMCAS), cellulose acetate phthalate (CAP), carboxymethyl cellulose (CMC), polyvinyl pyrrolidone, polyvinyl alcohol (PVA), sodium alginate, polyethylene glycol, Locust bean gum, xanthan gum, tragacanth gum, guar gum, acacia gum, arabic Gum arabic, poly acrylic acid, methyl methacrylate copolymer, amylose, dextrin, chitin, chitosan, levan , Elsinan, collagen, gelatin, glucan high amylose starch (corn starch, potato starch, wheat starch, rice starch, mung bean starch, yellow bean starch, etc.), esterification Starch products, soy protein isolate, whey protein isolate, casein, gellan, pectin and the like. These may be used alone or in combination of two or more. When two or more kinds of these film-forming high molecular materials (A) are used, they can also be used as a mixture. In the touch film-forming polymer material (A), it is preferable to use a weight average molecular weight of 1,000 to 2,000,000 g / mol in terms of film formability and processing. If the weight average molecular weight is less than 1,000 g / mol it may be difficult to form a film because the viscosity is low, and if the average molecular weight exceeds 2,000,000 g / mol, the viscosity is difficult to process.

In addition to the touch film-forming polymer material (A) described above, a hydrophilic natural polymer material having a weight average molecular weight of 1,000 to 2,000,000 g / mol, which is generally known in the art, may also be used as the film forming material.

(B) gelling agent

The gelling agent in the skin soluble touch film of the present invention is characterized by gelling when cooled with a material used to prevent the film from chipping. Examples of gelling agents include, but are not limited to, locust bean gum, xanthan gum, carrageenan, gelatin, gellan gum, agar, alginate alginates, guar gum, starch, pectin, ethyl cellulose, methyl cellulose, sodium carboxy methyl cellulose, polyethylene glycol natural gelling agents such as glycol). These may be used alone or in combination of two or more, and may also be used in a mixture when two or more kinds are used.

The gelling agent (B) in the touch film may be included in the film at 0.1 to 50 parts by weight, preferably 0.4 to 30 parts by weight, per 100 parts by weight of the polymer material (A). When the mixing ratio of the gelling agent (B) is less than the above range, the film is easily curled, and when the ratio exceeds the above range, the solubility of the film is lowered.

(C) plasticizer

Plasticizers in the skin soluble touch film of the present invention are used for imparting properties such as anti-curing, anti-sticking and plasticity. The plasticizer can also lower the glass transition temperature in the manufacturing process to control the melt viscosity. Examples of plasticizers include, but are not limited to, organic compounds having at least one hydroxyl group, such as polyol, sorbitol, mannitol, glycerin, propylene glycol, polyethylene glycol (polyethylene glycol), glycerol mono esters of fatty acids, sugar alcohols, monosaccharides, oligosaccharides, triethylene glycol, myvacet, triethylcitrate, Triacetin, propylene glycol monocaprylate, propylene glycol dicaprylate, miglyol and the like. In addition to the plasticizer, organic compounds such as alcohols and polyols having one or more hydroxyl groups may also be used. These plasticizers may be used alone or in combination of two or more, and may also be used in a mixture when two or more kinds are used.

The plasticizer (C) is included in an amount of about 0.1 to 40 parts by weight based on 100 parts by weight of the polymer material (A) forming the touch film. When the mixing ratio of the plasticizer (C) is less than the above range, the drying resistance of the film is lowered, and when it exceeds the above range, the sticking resistance of the film is deteriorated.

(D) active ingredients

Soluble film according to the present invention includes an active ingredient to produce the desired action, effect in the manufacture according to its use. Active ingredients include drugs, drugs, functional substances, and the like, which are applied and absorbed by the human body to promote structural and functional changes to produce the intended effect.

These active ingredients are not particularly limited, and any material which is physiologically acceptable and compatible with the film forming material and exhibits the intended activity in accordance with the intended use of the film may be used. Examples of active ingredients include, but are not limited to, coenzyme-Q10, vitamin 6, vitamin E (tocopherol), caffeine, vitamin E, menthol, jojoba oil, grape seed oil, fibroin, kojic acid ( Kojic acid, arbutin, vitamin C derivatives, rucinol, rhubarb extract, oil-soluble licorice extract, tea tree oil, collagen, hyaluronic acid, green tea extract, scrubber extract, allantoin, sodium-alginate (Algae extract), albumin and amino acid complexes, hydroxyproline, olive oil, palm oil, coconut oil, evening primrose oil, camellia oil, avocado oil, essence oil, dimethicone, cyclomethicone, IPM (Isopropyl Myristate), silk Animoic Acid, Glycerin, Polyethylene Glycol, Panthenol (Pro Vitamin B5), Lipidur, Betaine, Moistine, Honey, Urea, Hydro Moisque, Ceramide, Propylene Glycol , High cell, stearic acid, polyquater, carbopol progel, carbopol, kaolin, solusol, solubilizer, transparent solubilizer (polysorbate, Hco 60 etc.), vital emulsion, emulsifying wax, montano wax , Olive oil wax, olive liquid, lecithin, cetyl alcohol, setar alcohol, cetose, glycerol stearate, miglyol, moisture cream emulsifier, vitamin E (natural tocopherol), vitamin acetate, GSE (grapefruit) Seed extract), complex vitamin (vitamin ABCDE), retinol (VA), acacia collagen, marine collagen, carrot collagen, elastin, soluble cystine, kerasgen, vegetable placenta, biorange, wine paper, effectin, aloe bella Liquid, Aloe Moist, White Range, Pytens, Oxylic Acid Extract, Coswhite, Phytoclear, Titanium Dioxide (TiO ₂ ), Zinc Oxide (Zinc Oxide), Synmate, Propolis, Trichromic Acid, Silic Acid, Sun Herbal irritants such as jain, clean range, acopripowder, cypress essential oil, infracin, phytostan, soybean, centella, chamomile and licorice, anti-cellulite such as seaweed, green tea, ivy and horse chestnut , Platinum, adenosine, triethylene glycol, myvacet, triethyl citrate, 1,3-butylene glycol, triacetin, propylene glycol monocaprylate, peptide, sorbitol, mannitol, sodium fusidate , Antioxidants (EDTA), propylene glycol dicaprylate, sodium bicarbonate, sodium citrate and amino acids, hyaluronic acid, amyloglucosidase, antibiotics, adrenal cortex At least one active ingredient selected from the group consisting of hormonal agents (hydrocortisone acetate) and the like may be used. The active ingredient may be used alone or in combination of two or more. When two or more kinds are used, they may be used in combination with the active ingredient mixture in the manufacture of the film.

The active ingredient may be included in the film in the range of 0.001 to 40% by weight, preferably 0.001 to 20% by weight of the total weight of the skin soluble touch film. Wherein the active ingredient is based on the total weight of the final touch film, which will be described later to the drying step and stabilization step as needed. The active ingredient is added in an amount of 0.001% by weight or more so that the functionality of the active ingredient to be added is sufficiently represented. When the active ingredient exceeds 40% by weight, film formation becomes difficult, which is not preferable.

(E) Other additive ingredients

The skin soluble touch film of the present invention, if necessary, for the purpose of improving the physical properties required in the skin soluble touch film, other additives may be included as an optional component as needed. These other additives include, but are not limited to, for example, perfume oils, cold agents, surfactants, stabilizers, emulsifiers, thickeners, binders, colorants, pigments, flavors, preservatives, fungicides, antimicrobial agents, pharmaceutical activations. It may contain components such as agent.

More specifically, but not limited to, for example, thickeners (but not limited to, for example: methyl cellulose, carboxyl methyl cellulose, etc.); Dyes and colorants (but are not limited to, for example, colorants such as natural and tar colors); Flavoring agents (but not limited to, for example, menthol, peppermint, refreshing agents such as peppermint, spearmint, flavoring agents such as natural or synthetic flavorings), as well as flavorings, oils and plant extracts used in the general cosmetics industry (plant extract), herbal ingredients (vitamins), minerals (minerals), nitroglycerin, catechins, polyphenols, enzymes, emulsifiers, fragrances Fractions, fats, oils, etc., these other additives may be used alone or in combination of two or more. When 2 or more types are used, these can be mixed and used.

The other additives may be formulated so as to be up to 40% by weight, preferably 0.01 to 30% by weight, based on the total weight of the skin soluble touch film finally obtained as an optional ingredient. Wherein the other additives are based on the total weight of the final touch film, which will be described later to the drying step and stabilization step as needed. The other additives are optional components, but the lower limit content is not particularly limited, but when added, the content of the active ingredient with respect to the final film is blended in an amount of 0.01% by weight or more so as to show sufficient physical properties by addition. If it exceeds, film formation becomes difficult and it is not preferable.

The composition having the composition as described above is melt mixed to prepare a polymer solution (touch film forming composition) and cast it into a film to prepare the skin-soluble touch film of the present invention. Hereinafter, the method for producing a skin-soluble touch film according to the present invention will be described in detail.

2. Method for manufacturing skin soluble touch film

(1) Preparation of Touch Film Forming Composition

Forming the touch film (A) A polymer film, (B) gelling agent, (C) plasticizer, (D) active ingredient and (E) other additive ingredient are dissolved in water to prepare a touch film forming composition. At this time, the components can be dissolved while heating at a temperature that does not impair the physical properties of each component to dissolve and mix in a solvent more easily. The touch film-forming polymer composition is (A) 0.1 to 50 parts by weight of the gelling agent and (C) 0.1 to 40 parts by weight of the plasticizer and the total weight of the skin-soluble touch film per 100 parts by weight of the touch film-forming polymer material (A) Based on (D) 0.001 to 40% by weight of the active ingredient and (E) up to 40% by weight of other additives can be formulated. Meanwhile, the content of the (A) polymer material in the touch film forming composition is about 1 to 99% by weight, preferably about 15 to 80% by weight, based on the total weight of the touch film forming composition. The remainder other than the polymer material (A) may be composed of (B) gelling agent, (C) plasticizer, (D) active ingredient, (E) other additives and solvent. If the content of the polymer material in the touch film forming composition is less than 1% by weight, it is difficult to form a film, and since other components such as other solvents should be blended, the polymer material may be blended at a maximum of 99% by weight of the composition. The amount of water in the touch film forming composition is not particularly limited in manufacturing the film of the present invention, and each component constituting the touch film forming composition may be used in any amount suitable for sufficiently dissolving and forming a film. The skilled person is understood to appropriately control the amount of water required.

At this time, the mixing order of the components (A) to (E) is not particularly limited, and those skilled in the art may arbitrarily adjust in consideration of the physical properties and properties of each component used. In addition, each of the components may be dissolved alone or by selectively mixing any two or more components, which can be appropriately selected by those skilled in the art according to the properties and properties of the components used.

(2) film forming

A skin soluble touch film is formed using the touch film forming composition. The method of forming the touch film is not particularly limited, and may be performed by any method generally known in the art. For example, the touch film forming composition may be coated on a substrate (for example, a release film or paper coated with PP or PE) with a roller or film coater, or extruded to obtain a film. An extrusion method or a solution casting method of preparing the touch film-forming composition with a dope and casting the dope to obtain a film may be used for forming the touch film. The film is prepared by coating a base material (peel film) of various materials, at this time, to be coated with a uniform thickness in all areas.

(3) drying

The touch film formed in the form of a film has a moisture content of 50 wt% or less based on the total weight of the film with hot air of about 40 to 120 ° C., in order to obtain excellent properties related to drying resistance, sticking resistance, and solubility. Preferably it is dried to 1 to 50% by weight. If the temperature at the time of drying is less than 40 ℃ solvent or water volatilization is not good, the drying is slow and not preferable, and if it exceeds 120 ℃ there is a fear that the shape of the film is deformed. Since the lower the moisture content in the film is, the lower the lower limit of the moisture content is, there is no limitation, and the film may contain no moisture at all. However, it is preferable to contain about 1% by weight of water so that the film does not easily break, and when the water content exceeds 50% by weight, it is stretched and sticky.

(4) stabilization

The dried touch film is left in a humidity-controlled space or a constant temperature and humidity device to stabilize moisture content and the like. Stabilization is performed so that the water content of the touch film is about 50% by weight or less, preferably 1 to 50% by weight, so that excellent properties related to adhesion, preservation, etc. of the skin are expressed. Since the lower the moisture content in the film is, the lower the lower limit of the moisture content is, there is no limitation, and the film may contain no moisture at all. However, it is preferable to contain about 1% by weight of water so that the film does not easily break, and when the water content exceeds 50% by weight, it is stretched and sticky. Stabilization is generally performed for 1 to 48 hours at a temperature of 20 to 30 ℃, humidity 30 to 50% so that excellent properties of the film can be exhibited. The stabilization conditions are general and are not particularly limited thereby. More specifically, stabilization can be done, for example, at 25 ° C. temperature and 45% relative humidity, generally for 24 hours.

3. Skin Soluble Touch Film

Figure 1 shows a side cross-sectional view of the skin soluble touch film of the present invention, the skin soluble touch film of the present invention, as shown in Figure 1, the skin soluble touch film (2) carrying the active ingredient is a release film (or It is formed on (1) the 'release' or 'substrate'.

In order to obtain excellent properties such as drying resistance, form stability, peelability, skin adhesion, solubility, and supporting of functional components of the skin-soluble touch film, the touch film has a thickness of 1 to 5000 µm, preferably about 1 to 1000 µm. It is good to be If the thickness is less than 1㎛, it does not properly load (load) the characteristics and quantity of the active ingredient to contain and release, and it is difficult to handle due to the thin film.If the thickness exceeds 5000㎛, the decomposition or dissolution of the film becomes slow and adheres to the surface completely. It is not preferable at the point of attachment.

In addition, the touch film of the present invention is 50% by weight or less, preferably 1 to 50% by weight of water based on the total weight of the film. Since the lower the moisture content in the film is, the lower the lower limit of the moisture content is, there is no limitation, and the film may contain no moisture at all. However, it is preferable to contain about 1% by weight of water so that the film does not easily break, and when the water content exceeds 50% by weight, it is stretched and sticky.

The film of the present invention is a form that can be applied to any specific site of the skin, it can be produced in any shape and size desired according to the application site and use. For example, but not limited to, the skin-soluble touch film is rectangular, round, star, triangular, pentagonal, hexagonal, oval, heart-shaped, clover, equilateral quadrangle, trapezoidal, octagonal, octagonal, half moon-shaped, face-shaped , Animal shape, hand shape, foot shape, lip shape, eye shape, nose shape, ear shape, weight form, hip shape, chest shape, nail shape, claw shape, finger shape, toe shape, knee shape, or lozenge shape Can be prepared. In addition, the skin soluble touch film is 0.1cm ² to 900cm ² It can be prepared in the area of. The area of the touch film is 0.1cm ² If less than, it is difficult to separate the film on the substrate and attach it to the skin. If it exceeds 900cm ² , it can be cut and used as required by the user's request, but it causes a disadvantage in that it is difficult to store and carry.

In addition, it is possible to manufacture the width and length of about 30cm to use the opened product at a time, this sheet-like soluble touch film is shown in FIG. The soluble touch film of the present invention may be used in several sheets at once, for example, about 1-10 sheets.

The skin soluble touch film of the present invention may be vacuum-packed, and in this case, chemical reaction between the active ingredient and moisture in the air may be prevented until use, thereby preventing the change of the active substance. Accordingly, deterioration of the product is prevented, and it is easy and simple to store, manage and carry.

The soluble touch film according to the present invention may be used with an aqueous film solubilizer to exhibit better solubility, absorbency and solubility of the active substance when applied to the skin.

Hereinafter, the method of using the soluble touch film of the present invention using the film dissolving agent and the film dissolving agent used in the application of the soluble touch film of the present invention will be described in detail.

4. Film Solvent

In the present invention, the film dissolving agent is used to further provide faster solubility and absorbency and excellent functionality of the active substance in applying and using the prepared skin-soluble touch film on the skin.

The film solubilizer can be used as long as it is a cosmetic formulation containing water (hereinafter referred to as a 'moisture-containing cosmetic formulation'). Water can also be used as film solubilizer. The film dissolving agent of the water-containing cosmetic formulation may be prepared in various cosmetics such as creams, lotions, skins, lotions, essences, etc. More specifically, for example, massage creams, nutrition lotion, astringent lotion, nutrition cream, nutrition oil, Facial cosmetics, packs, basic cosmetic products such as eye cream and whitening, anti-wrinkle, UV protection, or multi-functional cosmetics having a duplicate of these functions can be used.

The film solubilizer of the 'moisture-containing cosmetic formulation' used in the application of the soluble touch film of the present invention has a water content of 10 to 99% by weight, preferably 30 to 99% by weight, more preferably 30 to 90% by weight. Used. If the moisture content is less than 10% by weight, the film is attached and the effect of quickly dissolving and absorbing is not sufficiently exhibited. In addition, since the functional cosmetics and the like should be blended, the water content is up to 99% by weight, and if the water content exceeds 99% by weight, it is not suitable for manufacturing into cosmetics. The non-moisture component in the film dissolving agent of the 'moisture-containing cosmetic formulation' may enhance the effect according to the supported functional material of the skin soluble touch film and is generally used for preparing cosmetic raw materials and / or other cosmetics having affinity for skin. It may be a component formulated into. Although not limited thereto, examples of cosmetic raw materials may include conventional ingredients such as aqueous vitamins, oily vitamins, polymer peptides, polymer polysaccharides, sphingolipids and the like. In addition, other ingredients commonly formulated in cosmetics, such as oils and fats, emollients, surfactants, organic and inorganic pigments, organic powders, pH adjusters, UV absorbers, antioxidants, viscosity modifiers, plants and natural ingredients as needed. Extracts, alcohols, pigments, flavorings and the like can be added.

The film dissolving agent may be easily prepared by a method generally known to those skilled in the art, and the manufacturing method is not particularly limited. That is, it can be prepared by the conventional cosmetic preparation method of the cosmetic lotion and liquid form known to those skilled in the art.

5. Method of Use (Application) of Soluble Touch Film Using Film Solvent

The film dissolving agent is applied to a desired amount (for example, the edges of the eyes, the middle of the eye, around the mouth, the neck, the lips, and the human skin such as the nipple) to the film size, and then spreads thickly. Thereafter, each film is removed from the release paper using a finger or a pinch without moisture, and then placed on a straight film dissolving agent. Once the film begins to melt, the film dissolving agent is applied to the film or fingertips and massaged in a circle to absorb it completely into the skin.

The skin soluble touch film of the present invention effectively supports the active material and exhibits solubility and rapid efficacy of the active material when applied to the skin. More specifically, the skin soluble touch film according to the present invention is dissolved within 100 seconds, more specifically 0.1 to 100 seconds at a temperature of about 10 ~ 70 ℃, preferably about 10 ~ 50 ℃, the active ingredient is Absorbed in the application area. In addition, the soluble touch film of the present invention, depending on the active substance, soothing effect of sensitive skin, atopic treatment, acne treatment, wrinkle improvement, anti-inflammatory treatment, anti-aging, antioxidant action, whitening effect, skin soothing, skin moisturizing effect, nutrient It can be used for cosmetics and general medicines such as skin care and skin care such as supply, care and improvement, diet patch, exfoliation, promoting metabolism, enhancing skin elasticity and giving flexibility, and removing scars. The skin-soluble touch film of the present invention can be provided as cosmetics such as various cream lotion skin lotion and the like and provide cosmetics such as shampoo, rinse, cleansing, face wash, soap, treatment, essence and the like.

Hereinafter, the skin-soluble touch film according to the present invention will be described in detail through Examples. The following examples illustrate the invention but do not limit the invention to the following examples.

 (Example 1)

(1) Preparation of polymer solution (touch film forming composition) for skin soluble touch film formation

0.6% by weight of Tween ™ 80, 0.3% by weight of sorbitol, 0.8% by weight of propylene glycol, 0.4% by weight of glycerine, and a weight average molecular weight of 200,000 (g / 23% by weight of moul) pullulan, 0.1% by weight of carrageenan, 0.1% by weight of locust bean gum (LBG), and 0.1% by weight of xanthan gum were added and all the ingredients were completely heated. Disperse and dissolve until dissolved. The temperature of the solution in which each component is completely dissolved is reduced to 40 ° C., to which 1% by weight of adenosine, 3% by weight of vitamin C, 0.01% by weight of gardenia yellow and 0.59% by weight of an aqueous acetylhexapeptide 8 solution are added. The solution is prepared by stirring until all components are uniformly dispersed and dissolved. The viscosity of the prepared solution was about 7,000-8,000 mPa.s (25 ° C). The solution was left at room temperature for 6 to 24 hours to remove bubbles.

(2) Formation of skin soluble touch film by coating method

After applying the appropriate amount of the prepared solution (touch film forming composition) on the release film was adjusted to a film coater (Film coater) in consideration of the required thickness of the film was cast (casting) to a final thickness of 45㎛. .

(3) dry skin soluble touch film

The touch film formed in the step (2) is dried for about 1 minute with hot air of about 80 ~ 110 ℃ to adjust the moisture content of 7 to 13% by weight.

(4) Skin Soluble Touch Film Molding

Then, by lowering the cutting machine equipped with a knife blade of the desired film form to leave the release paper, only the soluble touch film carrying the active ingredient is cut into the desired shape, the desired shape on the release paper (substrate) as shown in Figure 2 Only the touch film was left. In this manner, a skin-soluble touch film having an area of 2.25 cm ² (width 1.5 cm, height 1.5 cm) and a film thickness of 45 μm was obtained.

(5) Stabilization of skin soluble touch film

The touch film obtained in step (4) was stabilized by standing at 25 ° C. temperature and 45% relative humidity for 24 hours in a constant temperature and humidity device. The touch film after stabilization has a water content of about 7 to 13% by weight. The film produced in this example is illustrated in FIG.

(6) Availability test of skin soluble touch film

The solubility of water in the prepared skin-soluble touch film was measured. Solubility test is to put the prepared touch film in water of 0 ~ 70 ℃ and shake carefully 2-3 times so that the film does not stick to the wall surface of the container containing lukewarm water, and then measure the time it takes for the film to dissolve completely The solubility of the film was evaluated. The evaluation results for the availability are shown in FIG. 3. The touch film of this embodiment having a thickness of 45 μm is within 80 seconds at 2 ℃, within 60 seconds at 10 ℃, within 48 seconds at 20 ℃, within 40 seconds at 30 ℃, within 28 seconds at 40 ℃, 15 at 50 ℃ It was dissolved both within seconds and within 4 seconds at 60 ° C.

(Example 2)

At room temperature, 70% by weight of purified water, 0.6% by weight of Tween ™ 60, 0.3% by weight of sorbitol, 0.8% by weight of propylene glycol, 0.4% by weight of glycerine and a weight average molecular weight of 200,000 ( g / mole), 20.6% by weight of pullulan, 0.1% by weight of carrageenan, 0.1% by weight of locust bean gum (LBG), and 0.1% by weight of xanthan gum were added and warmed to 70 ° C. Disperse and dissolve until it is completely dissolved. The temperature of the solution in which each component is completely dissolved is lowered to 40 ° C, and 4% by weight of arbutin, 2% by weight of vitamin C derivatives, and 1% by weight of jojoba oil are added thereto, and all components are uniformly dispersed and dissolved. Until a solution is prepared.

The solution is left for 6 hours or more to remove bubbles. The solution was then coated on a release film and cast to have a final thickness of 100 μm. The prepared touch film was dried with hot air at about 40 to 120 ° C. for 1 minute and stabilized at 25 ° C. and 45% relative humidity for 24 hours in a constant temperature and humidity device. The touch film has a water content of 7 to 9% by weight, and cut into sizes of 2 cm and 3 cm in length to produce a product.

(Example 3)

70.4% by weight of purified water, 0.6% by weight of sucrose fatty acid ester, 0.3% by weight of sorbitol, 0.9% by weight of propylene glycol, 0.4% by weight of glycerine, and a weight average molecular weight of 50,000 23% by weight of hydroxypropylmethyl cellulose (HPMC), 0.1% by weight of carrageenan, 0.1% by weight of locust bean gum (LBG) and 0.1% by weight of xanthan gum were added at 70 ° C. Warm to disperse and dissolve until all ingredients are completely dissolved. The solution was prepared by lowering the temperature of the solution in which each component was completely dissolved to 40 ° C., adding 4% by weight of fibroin and 0.1% by weight of adenosine, and stirring until all the components were uniformly dispersed and dissolved. do. Thereafter, a touch film was manufactured in the same manner as in Example 1 using the same.

Example 4 Preparation of Film Solvent and Use of Touch Film Using the Same

70.5% by weight of purified water was added to 8% by weight of 95% ethanol, and 2% by weight of polyoxyethylene, 2.3% by weight of cured perme oil, 5% by weight of glycerine, and 10% by weight of propylene glycol were thoroughly stirred. Then, 0.2% by weight of fragrance (aldehyde type) and 2% by weight of arbutin were added thereto, followed by stirring and dissolving to prepare a transparent liquid film dissolving agent.

The film dissolving agent is evenly spread on the edges of the eyes to which the touch film is to be applied, and the touch film prepared in Example 1 is removed from the release paper and then placed on the release film for spreading. Once the film begins to melt, reapply and massage the film solubilizer to absorb the active ingredients into the skin.

1 is a cross-sectional view showing a skin-soluble touch film formed on a release film according to the present invention,

2 is a photograph showing a skin soluble touch film prepared in Example 1,

3 is a graph showing the solubility results of the skin soluble touch film prepared in Example 1.

Brief description of the main parts of the drawing

1 ..... release film

2 ..... Skin Soluble Touch Film

Claims (11)

It has a form that can be applied to a specific area of the skin (A) 100 parts by weight of the touch film-forming polymer material, (B) 0.1-50 parts by weight of the gelling agent, (C) 0.1-40 parts by weight of the plasticizer and skin soluble touch film (D) based on the total weight of the active ingredient comprises 0.001 to 40% by weight, skin soluble touch film that is dissolved by a film dissolving agent on the skin. The skin soluble touch film of claim 1, wherein the skin soluble touch film has a water content of 50 wt% or less. The skin soluble touch film of claim 1, wherein the skin soluble touch film has a thickness of 1 to 5,000 μm. The skin soluble touch film of claim 1, wherein the skin soluble touch film is dissolved within 0.1 to 100 seconds at a temperature of 1 ~ 70 ℃. The method of claim 1, wherein the film-forming polymer material (A) is pullulan (pullulan), hydroxypropylmethyl cellulose (HPMC), hydroxymethyl cellulose (HMC), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), methyl cellulose (MC), hydroxypropylmethylcellulose phthalate (HPMCP), hydroxypropylmethylcellulose acetsuccinate (HPMCAS), cellulose acetate phthalate (CAP), carboxymethyl cellulose (CMC) ), Poly vinyl pyrrolidone, polyvinyl alcohol (PVA), sodium alginate, polyethylene glycol, locust bean gum, xanthan gum, Tragacanth gum, guar gum, acacia gum, gum arabic, poly acrylic acid, methyl methacrylate Sieve, amylose, dextrin, chitin, chitosan, levan, elsinan, collagen, gelatin, glucan, Corn starch, potato starch, wheat starch, rice starch, mung bean starch, high amylose starch such as yellow soybean starch, esterified starch products, soy protein isolate, whey protein isolate, casein, gellan ), Skin soluble touch film, characterized in that at least one selected from the group consisting of pectin (pectin). The skin-soluble touch film according to claim 1, wherein the (A) film-forming polymer material has a weight average molecular weight of 1,000 to 2,000,000 g / mol. The gelling agent of claim 1, wherein the gelling agent is locust bean gum, xanthan gum, carrageenan, gelatin, gellan gum, agar, alginates ), Guar gum, starch, pectin, ethyl cellulose, methyl cellulose, sodium carboxy methyl cellulose and polyethylene glycol Skin soluble touch film, characterized in that at least one selected from the group consisting of. According to claim 1, wherein the plasticizer sorbitol (sorbitol), mannitol (mannitol), glycerin (glycerin), propylene glycol (propylene glycol), polyethylene glycol (polyethylene glycol), glycerol monoester of fatty acids, sugar alcohol (sugar alcohol) , Monosaccharides, oligosaccharides, triethylene glycol, triethylene glycol, myvacet, triethylcitrate, triacetin, propylene glycol monocaprylate Skin soluble touch film, characterized in that at least one selected from the group consisting of propylene glycol dicaprylate and miglyol (miglyol). The method of claim 1, wherein the active ingredient is Coenzyme-Q10 (Coenzyme-Q10), vitamin 6, vitamin E (tocopherol), caffeine, menthol, jojoba oil, grapeseed oil, fibroin (fibroin), kojic acid, Arbutin, Vitamin C Derivative, Rucinol, Methanol Extract, Soluble Licorice Extract, Tea Tree Oil, Collagen, Hyaluronic Acid, Green Tea Extract, Scrubber Extract, Allantoin, Sodium-Alginate, Sodium-Alginate, Albumin and Amino Acid Complex Phosphorus Hydroxy Proline, Olive Oil, Palm Oil, Coconut Oil, Evening Primrose Oil, Camellia Oil, Avocado Oil, Essence Oil, Dimethicone, Cyclomethicone, Isopropyl Myristate (IPM), Silkanimoic Acid, Glycerin, Polyethylene Glycol, Panthenol (Provitamin B5), Lipidur, Betaine, Moistin, Honey, Urea, Hydro Moisque, Ceramide, Propylene Glycol, Natural Herbal Moisturizer, High Cell , Stearic acid, polyquater, carbopol progel, carbopol, kaolin, solusol, solubilizer, polysorbate, transparent solubilizer such as Hco 60, vital emulsion, emulsion wax, montan wax, olive oil wax , Olive Liquid, Lecithin, Cetyl Alcohol, Setar Alcohol, Cetose, Glycerol Stearate, Migriol (miglyol), Moisturizing Cream, Vitamin Acetate, GSE (Grapefruit Seed Extract), Compound Vitamin (Vitamin ABCDE), Retinol (VA), acacia collagen, marine collagen, carrot collagen, elastin, water-soluble cystine, kerasgene, vegetable placenta, biorange, wine oil, effectin, aloe vera liquid, aloe moist, white resin, whiteen Scotland, octanoic Yongsan extract, white course, Pitot clear, titanium dioxide (TiO _2), zinc oxide (zinc oxide), thinner formate, propolis, tri croissant acid, salicylic acid, a clean oven, Ako-free powder, Herbal irritants such as white essential oil, infracin, phytostane, soybeans, centella, chamomile and licorice, anti-cellulite such as seaweed, green tea, ivy and maronier, platinum, adenosine, triethylene Glycol, myvacet, triethyl citrate, 1,3-butylene glycol, triacetin, propylene glycol monocaprylate, peptide, sorbitol, mannitol, sodium fusidate, antioxidant (EDTA), propylene glycol dica Group consisting of propylene glycol dicaprylate, sodium bicarbonate, sodium citrate, amino acids, hyaluronic acid, amyloglucosidase, antibiotics, and corticosteroids (hydrocortisone acetate) Skin soluble touch film, characterized in that at least one selected from. The method of claim 1, wherein the skin-soluble touch film is rectangular, round, star, triangle, pentagon, hexagon, oval, heart shape, clover shape, equilateral quadrilateral, trapezoid, heptagon, octagon, half moon shape, face shape, animal shape, Applicable to hands, feet, lips, eyes, nose, ears, weights, hips, chest, nails, toenails, fingers, toes, knees, or lozenges It is characterized in that it is in any shape suitable for the area of 0.1 cm ² to 900 cm ² Skin soluble touch film, characterized in that below. The skin-soluble touch film according to claim 1, wherein the film dissolving agent is water or a water-containing cosmetic formulation having a water content of 10 to 99% by weight, or a secretion liquid discharged from the human body and soluble at human body temperature.

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