KR20200037574A - Cosmetic composition for preventing hair loss comprising heparin - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing hair loss, comprising a heparin salt such as heparin or sodium heparin as an active ingredient, thereby being effective in reducing scalp keratin and oil content and increasing tensile load of hair.

Description

Cosmetic composition for preventing hair loss comprising heparin {Cosmetic composition for preventing hair loss comprising heparin}

The present invention relates to a cosmetic composition for preventing hair loss comprising heparin, and more particularly, to a cosmetic composition for preventing hair loss by helping heparin keratin, oil and hair to improve tensile load by including heparin or a salt thereof as an active ingredient. will be.

Heparin was mainly produced by extracting from the lungs of cows or the intestines of pigs, but after the mad cow disease, the origin of heparin as a medicine is mostly derived from the small intestine mucosa of pigs. Usually, the pig small intestine mucosa is suspended in an aqueous medium to digest proteins, and then an adsorbent or the like is added to extract heparin and other mucopolysaccharides (mainly chondroitin sulfate family, heparan sulfate, etc.) as a complex to prepare crude materials.

Heparin is a mixture of acidic mucopolysaccharides containing sulfated D-glucosamine, D-glucuronic acid, L-iduronic acid, etc., present in the liver, small intestine, lungs, skin, etc. In addition to treatment and prevention of various thromboembolisms, such as treatment of intravascular vascular clotting syndrome, venous thrombosis, myocardial infarction, pulmonary embolism, cerebral embolism, limb artery thromboembolism, thromboembolism during and after surgery, in vitro circulatory devices such as hemodialysis and artificial cardiopulmonary It is used to prevent blood clotting during use, when a blood vessel catheter is inserted, or during blood transfusion and blood tests.

Prior arts related to the use of heparin include a composition containing heparin as a surface coating agent for non-thrombosis formation (Patent Document 1), a wound healing promoting ointment composition consisting of water-soluble chitosan and heparin (Patent Document 2), heparin or derivatives thereof Oral pharmaceutical compositions (Patent Document 3) for treatment of inflammatory bowel disease, ulcerative colitis, Crohn's disease, sigmoid colitis and / or proctitis have been disclosed.

However, there is no known new use of heparin as a hair loss prevention agent.

Patent Publication No. 10-2001-0079758 Patent Publication No. 10-2002-0066024 Patent Publication No. 10-2009-0065556

The present inventors have continuously conducted research to develop new uses of heparin to find out that heparin has an effect of preventing hair loss by helping to improve scalp keratin, oil and tensile load of hair, and completed the present invention.

Accordingly, an object of the present invention is to provide a cosmetic composition for preventing hair loss as a new use of heparin.

Because the scalp surrounds the surface of the head, it serves to maintain and protect the inside of the scalp by buffering external physical stimuli or chemical changes. In relation to excessive work, stress, irregular eating habits and lifestyle, the scalp pores of modern people are blocked due to external environment, sebum and sweat, or due to excessive or deteriorated function of the sebaceous glands.

Due to the imbalance of the scalp, dandruff occurs due to abnormal cycles of the epidermal stratum corneum. Dandruff is shortened to 3-7 days compared to the normal period of 2 weeks, and the stratum corneum accumulates and falls off at once. .

If excessive dandruff is produced, itchiness occurs, the irritated area swells red, and the scalp becomes wet, causing inflammation. In some cases, it also causes skin diseases such as psoriasis or seborrheic dermatitis.

Dandruff scalp can be divided into oily dandruff and dry dandruff. Dry dandruff has a small amount of sebum, so there is little oil content even if it is not detected for 2-3 days, and it occurs a lot in the autumn and winter seasons. Without inflammation, keratin formation is rapid and each side is accompanied by severe itching with dry dandruff. Overall, the dandruff is excited and has a white tone, and the periphery of the pores is stained. Oily dandruff is a condition in which the scalp and dandruff of the scalp are mixed with sebum from the sebaceous glands, which is oily and occurs mainly in the summer.

In addition, dandruff has sweat, fine dust, and keratin. It blocks pores and causes trophic disorders and atrophy, causing hair loss. It is accompanied by an increase in dandruff and itching due to abnormal growth of dandruff bacteria.

In order to prevent scalp skin diseases and hair loss, cleansing of the scalp is required, and in order to maintain a healthy scalp, it removes sebum, foreign substances, and dead skin cells around the pores that interfere with hair growth, and has a moisturizing effect or nutritional effect on the scalp. It is necessary to activate scalp regeneration or scalp cells using an existing product.

Accordingly, the present invention provides a cosmetic composition for preventing hair loss, which includes heparin or a salt thereof as an active ingredient in order to solve the above problems.

The cosmetic composition for preventing hair loss according to the present invention can prevent skin diseases and hair loss of the scalp, remove sebum, foreign substances and aging keratin accumulated around the pores, which are obstacles to hair growth, and have a moisturizing effect or nutritional effect on the scalp. Therefore, there is an effect that can regenerate the scalp or activate the scalp cells.

Figure 1 shows the results of the evaluation of the scalp keratin using an enlarged image of the scalp before (left) and after 4 weeks of use (right) of sodium heparin.
FIG. 2 shows an image (60 times) comparing the scalp keratin using an enlarged image of the scalp before (left) and 4 weeks (right) sodium heparin.
Figure 3 shows the results of the analysis of the scalp fraction using the photometric measurement principle before (left) and after 4 weeks of use (right) of sodium heparin.
Figure 4 shows the results of hair tension load analysis using a universal testing machine before (left) and after 4 weeks of use (right) of sodium heparin.

The present invention relates to a cosmetic composition for preventing hair loss comprising heparin or a salt thereof as an active ingredient.

In the cosmetic composition for preventing hair loss of the present invention, the salt may be a sodium salt or a calcium salt, preferably a sodium salt.

In the cosmetic composition for preventing hair loss of the present invention, the activity of the heparin or its salt may be 50 to 180 IU / mg, preferably 80 to 150 IU / mg, but is not limited thereto. When the activity of the heparin or its salt is 50 IU / mg or less, the activity is low and impurities are high, so it is difficult to achieve the desired effect, and if it is 180 IU / mg or more, it is not preferable because it requires a high purification cost.

The heparin or a salt thereof included in the cosmetic composition for preventing hair loss of the present invention may be purchased and used through a manufacturer or a commercial sales network, or may be prepared and used in a conventional manner.

The cosmetic composition for preventing hair loss of the present invention may contain 0.01 to 1.0% by weight, preferably 0.03 to 0.6% by weight of the heparin or a salt thereof with respect to the total weight of the composition.

The formulation of the cosmetic composition for preventing hair loss of the present invention may be a shampoo, rinse, tonic, essence, lotion, conditioner, foam, gel, setting lotion, hair stick, blow, jimo coat, spray, mousse, aerosol or pomade formulation, , Preferably shampoo, conditioner, foam, gel, hair stick, spray, mousse, aerosol or pomade.

The cosmetic composition for preventing hair loss of the present invention may further include a thickener, an antiseptic, an antioxidant, a preservative, a skin moisturizer, a skin softener, a surfactant, L-menthol, a hair conditioning agent, and a fragrance used in a conventional cosmetic composition. You can.

The preservative is diazolidinylurea, the antioxidant is ethylenediamine tetraacetic acid disodium salt, the skin moisturizer is propylene glycol, and the skin softener is Glycol stearate, cocoamidopropyl betain as the hair conditioning agent, coconut monoethanolamide, sodium laureth sulfate, sodium lauryl as the surfactant Sodium lauryl sulfate is an example.

Hereinafter, the present invention will be described in more detail through examples, but this is for explaining the present invention in more detail, and the scope of the present invention is not limited thereby.

< Example  1> ( Sodium heparin  Anti-hair loss effect evaluation)

For the test, sodium heparin was prepared in-house, and was prepared as a tonic formulation having an activity of 300 IU / mL in a conventional manner and used as a sample.

Subjects are subject to 26 to 49-year-old subject selection criteria, and 21 samples of female subjects who do not meet the exclusion criteria are sprayed twice a day with samples 4 to 5 times on the hair and scalp to absorb evenly as if massaging. Was made.

(One). Scalp keratin evaluation

Aramo TS ^® (AramHuvis, Korea), which is a scalp imaging device, zooms in on the scalp keratin using a 60x lens, and then uses the enlarged scalp image to 7 steps (1, weak / clean; ~ 7, severe / dirty) A method of evaluating the condition of the scalp was used, and the degree of improvement of the scalp keratin was evaluated using images taken before and 4 weeks after the sample was used.

As a result of scalp keratin analysis, as shown in Table 1, FIGS. 1 and 2, it was significantly reduced (p <0.05) at a time point after 4 weeks of sample use, and the reduction rate was 47.30%, and the sample improved scalp keratin It was evaluated to be effective.

time N Average (score) Standard Deviation p -value Decrease rate (%) Before use 21 3.52 0.49 - - 4 weeks after use 21 1.86 0.62 0.000 47.30 ▼

(2). Scalp oil evaluation

The amount of scalp oil is a synthetic synthetic tape with a thickness of 0.1 mm on the Sebumeter-cassette, and the cassette is inserted into the slot of the device using the principle of the photometric measurement method of Sebumeter ^® SM810 (C + K, Germany) that directly measures sebum secreted from the skin. When fitted, the light source passing through the tape was measured as a numerical value (μg sebum / cm ² ), and the amount of oil in the frontal region was measured before and 4 weeks after use, and then analyzed and evaluated.

As a result of scalp oil analysis, as shown in Table 2 and FIG. 3, the sample was significantly reduced at 4 weeks after use (p <0.05), and the reduction rate was 27.54%, and the sample was effective in improving the scalp oil. It was evaluated to be.

time N Average (㎍ / ㎠) Standard Deviation p -value Decrease rate (%) Before use 21 58.10 24.16 - - 4 weeks after use 21 42.10 22.05 0.000 27.54 ▼

(3). Hair tension load evaluation

The tensile load of the hair was evaluated using a universal material tester (QC-508E®, Cometech, Taiwan). Tensile test is a test that measures the resistance of a material to a force applied at a constant speed. It measures the change in load according to the tensile force of the specimen per mm by applying a load to the specimen, and the tensile load (unit: gf) is the force on the hair. When it is applied and pulled, it gradually increases and the hair becomes thinner and eventually ends, which is the maximum weight exerted by the force.

This test was evaluated after analyzing the average value by measuring the tensile load of the hair collected before and 4 weeks after using the tensile load rig of the universal testing machine.

As a result of hair tension load analysis, as shown in Table 3 and FIG. 4, it was significantly improved (p <0.05) at the time point after 4 weeks of sample use, and the increase rate was 12.69%. It was evaluated as effective.

time N Average (gf) Standard Deviation p -value Growth rate (%) Before use 21 616.64 142.16 - - 4 weeks after use 21 694.90 138.91 0.001 12.69 ▲

(4). Sensory evaluation by the subject

A sensory evaluation of the efficacy and usability of a sample is a 1-5 scale (1, not at all; 2, it is not; 3, moderate; 4, it is; 5, very) at 4 weeks after sample use. Yes / 1, not at all good; 2, not good; 3, moderate; 4, good; 5, very good), and analyzed positive answers (choice 4 and 5).

(4-1). Efficacy evaluation

As a result of the analysis, as shown in Table 4 (n = 21), 57.14% to 90.48% of the subjects responded positively to all items at the time point 4 weeks after the sample was used.

In Table 4 below, frequency represents the number of positive responses (4: Agree to 5: very agree), and the ratio represents the ratio of the number of positive responses to the total number of people (21).

division Frequency (N) ratio(%) Keratin reduction 14 66.67 Oil reduction 17 80.95 Refreshing 19 90.48 Scalp softness 12 57.14 Itching symptom improvement 16 76.19

(4-2). Scalp safety evaluation

Subjective skin irritation and objective skin irritation were evaluated at the point of 4 weeks after sample use through observation of the paper and the examiner.

As shown in Table 5 (n = 21) in the sensory results regarding usability, 76.19% to 80.95% of the subjects responded positively to the items 'color', 'viscosity', 'absorption power', and 'satisfaction'.

In Table 5 below, frequency represents the number of positive responses (4: good to 5: very good), and the ratio represents the ratio of the number of positive responses to the total number of people (21).

division Frequency (N) ratio(%) incense 10 47.62 color 16 76.19 viscosity 17 80.95 absorptivity 17 80.95 satisfaction 16 76.19

As described above, the scalp keratin and scalp fraction were significantly decreased at the time point 4 weeks after the sample was used, and the hair tensile load was also significantly increased, and both the sensory effect and the scalp safety were positive, so the sample containing sodium heparin It can be seen that has the effect of preventing hair loss.

< Example  2> Cosmetic  Preparation of composition (shampoo)

Shampoo of the following composition was prepared using the same method as the general shampoo manufacturing method.

Sodium lauryl sulfate ----- 30.00 wt%

Cocamide DEA ------------------ 2.00 wt%

Cocoamido propyl betain-3.00 wt%

Propylene glycol ----------------------------------- 0.20% by weight

Polyacrylamide ------------------------------- 0.50 wt%

Citric acid ----------------------------------------- 0.10% by weight

Flavoring --------------------------------------------- 0.50% by weight

NaCl --------------------------------------------- 0.60 wt%

EDTA --------------------------------------------- 0.10 wt%

Sodium Heparin (100 IU / mg) ------------------------- 0.30 wt%

Purified water ------------------------------------------- Remaining amount

< Example  3> Cosmetic  Composition (scalp tonic )

The scalp tonic of the following composition was prepared using the same method as the general scalp tonic.

Cocoamido propyl betain-2.00 wt%

EDTA --------------------------------------------- 0.03 wt%

Hyaluronic acid --------------------------------------- 1.00% by weight

Lactic acid --------------------------------------------- 0.001% by weight

Butylene glycol ------------------------------------- 8.00% by weight

Methylparaben --------------------------------------- 0.20 wt%

Peppermint oil ------------------------------------ 0.01% by weight

Ethyl alcohol --------------------------------------- 15.00 wt%

PEG-4-hydrogenated castor oil --------------- 0.70 wt%

L-menthol ------------------------------------------- 0.001 wt%

Polyacrylic acid ------------------------------------ 0.10% by weight

Flavoring ------------------------------------------- 0.50% by weight

Sodium heparin (150 IU / mg) -------------------------- 0.20 wt%

Purified water ------------------------------------------- Remaining amount

In the cosmetic composition for preventing hair loss according to the present invention, both the scalp keratin and the scalp oil were significantly reduced, and the hair tensile load was also significantly increased to remove sebum, foreign substances, and aging keratin, which are obstacles to hair growth. It has a nutritional supply effect, and can be usefully applied to prevent scalp skin disease and hair loss.

Claims (5)

A cosmetic composition for preventing hair loss comprising heparin or a salt thereof as an active ingredient. The cosmetic composition for preventing hair loss according to claim 1, wherein the salt is a sodium salt or a calcium salt. The cosmetic composition for preventing hair loss according to claim 1, wherein the activity of the heparin or its salt is 50 to 180 IU / mg. The cosmetic composition for preventing hair loss according to claim 1, wherein the heparin or a salt thereof is contained in an amount of 0.01 to 1.0% by weight based on the total weight of the composition. According to claim 1, wherein the formulation of the composition is characterized in that the shampoo, conditioner, tonic, essence, lotion, conditioner, foam, gel, setting lotion, hair stick, blow, zimocoat, spray, mousse, aerosol or pomade formulation A cosmetic composition for preventing hair loss.

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