KR102513124B1 - Composition for improving environment of scalp, relieving odor of scalp and suppressing danddruff - Google Patents

Abstract

The present invention relates to a composition for improving scalp health, which contains palmarosa oil, piroctone olamine, and at least one of succinic acid and terpineol as active ingredients. The composition for improving the scalp health according to an aspect of the present invention can properly control the amount of sebum secretion of the scalp and fundamentally improve the health of the scalp, such as inhibiting the proliferation and growth of dandruff bacteria. Therefore, the composition for improving the scalp health according to the present invention can be expected to control odor from the scalp, alleviate scalp acne, skin problems, inflammation and itching, and reduce the dandruff.

Description

Composition for improving scalp environment, alleviating scalp odor and inhibiting dandruff

The present invention relates to a composition for improving scalp health, comprising palmarosa oil, pyroctonolamine, and at least one of succinic acid and terpineol as active ingredients.

In addition, the present invention relates to a composition for improving the scalp environment, mitigating scalp odor, and inhibiting dandruff, comprising palmarosa oil, pyroctonolamine, and at least one of succinic acid and terpineol as active ingredients.

The scalp (SCALP) is a skin tissue covering the body surface of the skull, and is a body part where hair grows. Hair not only protects the scalp from external stimulants such as ultraviolet rays and maintains a constant temperature of the hair, but also has a great influence on determining the external beauty of a person. Accordingly, in modern society where the public's interest in appearance has increased, the general public is showing great interest in the health of the scalp and hair.

On the other hand, as we enter modern society, more and more people are complaining of suffering from deterioration in scalp and hair health due to various causes such as excessive use of styling agents, frequent perm and dyeing, and environmental pollution including fine dust.

Scalp and hair health deterioration is generally expressed as symptoms such as dry scalp, oily scalp, sensitive scalp, scalp inflammation, dandruff and hair loss. In a dry scalp, the oil/moisture balance is not right, so the scalp and hair are very dry, crumbly, and lacking in luster. In addition, the blood circulation of the scalp is not smooth, so dandruff is accumulated due to dead skin cells and hair loss may be induced. Oily scalp refers to the scalp in a state where dandruff and dead skin cells are entangled with sebum due to excessive secretion of sebum on the scalp, and sebum secretion clogs pores, causing inflammation or hindering hair growth, causing hair loss. Sensitive scalp is also called sensitive scalp, and capillaries are excessively dilated, so it reacts sensitively even to weak stimuli from the outside and an inflammatory reaction occurs explosively. Dandruff refers to the accumulation of dead skin cells on the scalp due to the abnormal proliferation of dandruff bacteria, and is divided into dry dandruff and oily dandruff. Hair loss refers to a phenomenon in which the cycle of hair does not reach its end of life and the hair falls out.

On the other hand, the pores of the scalp have a larger diameter than the pores existing on the skin of other parts, and unlike other skin, they have a structure in which waste materials can be accumulated well, such as being covered with hair, and the scalp is different from the skin of other parts. In comparison, there are many sebaceous glands, which is a favorable environment for the growth of microorganisms. Therefore, it is known that it is difficult to restore the scalp to a healthy state when the health of the scalp deteriorates due to an ignorance of the oil-moisture balance in the scalp. Accordingly, a wide variety of hair products have been developed over the past few years, but no product with a clear effect has been reported yet.

KR 10-2323101 B1

In one aspect, an object of the present invention is to improve scalp health.

In one aspect, an object of the present invention is to improve the environment of the scalp.

In one aspect, an object of the present invention is to suppress the occurrence of malodor in the scalp, particularly the crown, and to remove or mitigate the generated malodor.

In one aspect, an object of the present invention is to improve acne, trouble, inflammation and itching on the scalp.

In one aspect, an object of the present invention is to appropriately control the amount of sebum secretion on the scalp.

In one aspect, an object of the present invention is to inhibit the growth of dandruff bacteria and the production of dandruff.

In one aspect, an object of the present invention is to provide a scalp environment in which hair can grow healthily.

In one aspect, an object of the present invention is to improve and prevent hair loss due to deterioration of scalp health.

In order to achieve the above object, the present invention includes Palmarosa oil and Piroctone Olamine as active ingredients, and the Piroctone Olamine is based on 100 parts by weight of Palmarosa oil, 10 ^-4 It provides a composition for improving scalp health, which is included in parts by weight to 200 parts by weight.

The composition for improving scalp health according to one aspect of the present invention can fundamentally improve scalp health, such as appropriately controlling the amount of sebum secretion of the scalp and inhibiting the proliferation and growth of dandruff bacteria. Therefore, the composition for improving scalp health according to the present invention can be expected to control odor from the scalp, improve scalp stimulation/acne/trouble/inflammation/itching, and reduce dandruff.

1 is an experimental result confirming the scalp soothing effect after treating a hair composition according to an aspect of the present invention (left: before use, right: 2 weeks after use).
2 is an experimental result confirming the scalp blood circulation improvement effect after treatment with the hair composition according to one aspect of the present invention (left: before use, right: 2 weeks after use).

Hereinafter, each configuration will be described in more detail, but this is only one example, and the scope of the present invention is not limited by the following content.

Terms or words used in the specification and claims of the present invention are not limited to the usual or dictionary meaning, and the inventor can properly define the concept of the term in order to explain his/her invention in the best way. Based on the principle, it should be interpreted as a meaning and concept consistent with the technical idea of the present invention.

In one aspect, the present invention includes Palmarosa oil and Piroctone Olamine as active ingredients, and the Piroctone Olamine is included in an amount of 10 ^-4 to 200 parts by weight based on 100 parts by weight of Palmarosa oil. It is a composition for improving scalp health.

In addition, in one aspect, the present invention includes Palmarosa oil and Piroctone Olamine as active ingredients, and the Piroctone Olamine is based on 100 parts by weight of Palmarosa oil, in an amount of 10 ^-4 to 200 parts by weight. It is a composition for improving the scalp environment, which is included.

In the present specification, 'scalp environment' may mean a condition or condition of the scalp that directly or indirectly affects the health of the scalp and hair.

In one aspect, the composition may include 10 ^-3 parts by weight to 200 parts by weight of pyroctoneolamine, based on 100 parts by weight of Palmarosa oil, or 10 ^-2 parts by weight to 200 parts by weight, or 10 ^-1 parts by weight. to 200 parts by weight, or 1 to 200 parts by weight, or 10 parts by weight to 200 parts by weight, or 30 parts by weight to 200 parts by weight, or 50 parts by weight to 200 parts by weight, or 70 parts by weight to 200 parts by weight, or 90 parts to 200 parts, or 110 parts to 200 parts, or 110 parts to 180 parts, or 120 parts to 180 parts, or 120 parts to 170 parts, or 130 parts by weight 180 parts by weight, or 130 parts by weight to 170 parts by weight, or 140 parts by weight to 160 parts by weight may be included, but is not limited thereto.

When piroctonolamine and palmarosa oil are included in the above ratio, a better scalp improvement effect and scalp environment improvement effect can be exhibited.

In one aspect, the composition may further include at least one of succinic acid and monoterpenes.

In one aspect, when the composition further includes at least one of succinic acid and monoterpenes, a more improved scalp health or environmental improvement effect may be exhibited.

In addition, in one aspect, the succinic acid and monoterpenes are based on 100 parts by weight of palmarosa oil, respectively, in order, greater than 10 ^-4 parts by weight to 3000 parts by weight and greater than 10 ^-4 parts by weight to 200 parts by weight. .

Specifically, the succinic acid may be included in an amount of more than 10 ^-4 parts by weight to less than 3500 parts by weight, or 10 ^-3 parts by weight to less than 3500 parts by weight, or 10 ^-2 parts by weight to less than 3500 parts by weight, based on 100 parts by weight of Palmarosa oil. less than 3500 parts by weight, or 10 ^-1 parts by weight to less than 3500 parts by weight, or 1 parts by weight to less than 3500 parts by weight, or 10 parts by weight to less than 3500 parts by weight, or 100 parts by weight to less than 3500 parts by weight, or 1000 parts by weight part to less than 3500 parts by weight, or 2000 parts by weight to less than 3500 parts by weight, or 2500 parts by weight to less than 3500 parts by weight, or 2800 parts by weight to less than 3300 parts by weight, or 2800 parts by weight to 3200 parts by weight, or 2900 parts by weight to It may be included in 3100 parts by weight, but is not limited thereto.

Specifically, the monoterpenes may be included in more than 10 ^-4 parts by weight to 200 parts by weight, or 10 ^-3 parts by weight to 200 parts by weight, or 10 ^-2 parts by weight to 200 parts by weight, based on 100 parts by weight of Palmarosa oil. part, or 10 ^-1 part by weight to 200 parts by weight, or 1 part by weight to 200 parts by weight, or 10 parts by weight to 200 parts by weight, or 30 parts by weight to 200 parts by weight, or 50 parts by weight to 200 parts by weight, or 70 parts by weight to 200 parts by weight, or 90 parts by weight to 200 parts by weight, or 110 parts by weight to 200 parts by weight, or 110 parts by weight to 180 parts by weight, or 120 parts by weight to 180 parts by weight, or 120 parts by weight to 170 parts by weight It may be included in parts by weight, or 130 parts by weight to 180 parts by weight, or 130 parts by weight to 170 parts by weight, or 140 parts by weight to 160 parts by weight, but is not limited thereto.

In one aspect, when palmarosa oil, pyroctonolamine, succinic acid and monoterpenes are included in the above ratio, the most maximized scalp health or environmental improvement effect can be expected.

In one aspect, the monoterpenes are terpineol, eucalyptol, ocimene, myrcene, hinokitiol, menthol, camphene ) and pinenes, but may include one or more selected from the group consisting of, but is not limited thereto.

For example, monoterpenes not listed above may also be included in the composition of the present invention if there is no harm to the human body such as skin sensitization.

In one aspect, improving scalp health can include one or more of the following:

i) inhibition of scalp odor generation and alleviation of scalp odor;

ii) control of scalp sebum secretion;

iii) relief of one or more of scalp irritation, itching and trouble; and

iv) inhibiting the proliferation of dandruff bacteria or inhibiting dandruff production.

It is known that scalp odor or parietal odor is caused by a combination of stress-induced heat, scalp inflammation, reduced immunity, excessive sebum secretion, accumulated waste products, and bacterial propagation. Regardless, it can exhibit excellent odor suppression effect.

Dandruff means that dead skin cells on the scalp have come off. Dandruff is generally caused by an imbalance between the amount of sebum and water content on the scalp and the flora inhabiting the scalp. Malassezia furfur is known as the main bacterium causing dandruff, and recently, bacteria of the genus Propionibacterium and bacteria of the genus Staphylococcus have been pointed out in addition to Malassezia furfur.

Sebum is a semi-liquid oily substance secreted by the sebaceous glands, and its main components are cholesterol, fatty acids and ester compounds. It is known that sebum forms a fat film on the surface of the skin and hair to provide a moisturizing function, and the vitamin D precursor contained in sebum is converted to vitamin D by receiving ultraviolet rays and then absorbed back into the scalp to be involved in the production of human immune cells.

The amount of sebum secretion has a direct effect on the health of the scalp. When a smaller amount of sebum is secreted than an appropriate amount, the amount of moisture evaporation from the scalp and hair increases, creating a dry environment. In addition, when sebum is secreted excessively, dandruff-inducing bacteria proliferate actively, causing an inflammatory reaction, and metabolite waste products of sebum-dandruff-inducing bacteria clog pores, causing dermatitis, and causing scalp irritation and trouble.

In one aspect, the composition may be a cosmetic composition or a pharmaceutical composition.

In one aspect, the route of administration of the composition is not limited, but may be preferably transdermal or external skin.

In one aspect, the cosmetic composition, for example, hair dye, shampoo, rinse, serum, treatment, hair pack, ampoule, hair cream, hair styling agent, hair conditioner, ointment, hair gel, hair patch, mist, hair styling agent, It includes a composition used for scalp and/or hair, such as soap, but is not limited to the above examples.

The cosmetic composition may be provided in any formulation suitable for topical application. For example, it may be provided in the form of a solution, emulsion (W/O, O/W, W/O/W, etc.), suspension, solid, gel, powder, paste, microneedle, foam or aerosol composition. there is. Compositions of such formulations may be prepared according to conventional methods in the art.

The pharmaceutical composition according to one aspect of the present invention may be formulated for parenteral administration.

Formulations for parenteral administration include injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, and the like. The composition according to one aspect of the present invention may appropriately use surfactants, excipients, coloring agents, spices, preservatives, stabilizers, buffers, suspending agents, or other commonly used adjuvants.

The active ingredient included in the composition according to one aspect of the present invention may be provided by being mixed with a carrier or encapsulated in a carrier in the form of a container. When a diluent is used as a carrier, the diluent may be a solid, semi-solid or liquid substance that can act as a carrier, excipient or medium for the active ingredient. Examples of suitable carriers, excipients or diluents are lactose, dextrose, sucrose, sorbitol, mannitol, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydro hydroxybenzoate, talc, magnesium stearate or mineral oil. In another aspect of the present invention, the composition may further include a filler, an anti-agglomerating agent, a lubricant, a wetting agent, a flavoring agent, an emulsifier or a preservative.

In one aspect, the cosmetic composition and/or pharmaceutical composition of the present invention may include palmarosa oil, pyroctonolamine, succinic acid, and monoterpenes in an amount of 0.05 to 5.0% by weight, based on the total weight of the composition.

Specifically, palmarosa oil, pyroctoneolamine, succinic acid, and monoterpenes are each from 0.05 to 4.5% by weight, or 0.1 to 4.5% by weight, 0.1 to 4.0% by weight, or 0.1 to 3.5% by weight, based on the total weight of the composition, or 0.1 to 2.5%, or 0.3 to 2.5%, or 0.5 to 2.5%, or 0.5 to 2.0%, or 0.5 to 1.7%, or 0.7 to 1.7%, or 0.7 to 1.5%, or It may be included in 0.7 to 1.3% by weight, or 0.8 to 1.2% by weight, but is not limited thereto.

The cosmetic composition and pharmaceutical composition according to the present specification may further include functional additives and components included in general cosmetic compositions in addition to the components of the present specification. Examples of the functional additive include, for example, vitamins, peptides, polysaccharides, and other plant extracts. The cosmetic composition and / or pharmaceutical composition may include other components that can give a synergistic effect to the main effect within a range that does not impair the main effect.

Hereinafter, the present invention will be described in detail through preparation examples and experimental examples. These examples are only for exemplifying the present invention, and the scope of the present invention is not limited by these examples.

[Production Example]

Compositions (Examples 1 to 5, Comparative Examples 1 to 6) were prepared by mixing according to a conventional method using the components and ratios shown in Table 1 below.

※ Unit: weight ratio

On the other hand, Comparative Examples 4 and 5 had poor stability due to precipitation of pyroctoneolamine and succinic acid, which contained excessive amounts of 4-terpineol. I felt a sense of stimulation.

[Experimental example]

[Experimental Example 1], scalp stimulation, itching, trouble, dandruff relief

A satisfaction survey was conducted on the comprehensive evaluation of scalp improvement (irritation, itching, trouble, dandruff relief) by using it on the scalp for 10 men and 10 women in their 20s and 30s, respectively, and the results are shown in Table 2. After using the hair tonic samples to which 1.0% of the compositions of Examples 1 to 5 and Comparative Examples 1 to 3 in Table 1 were applied for 2 weeks, the feeling was evaluated in 5 stages as an evaluation scale, and the score was 5 out of 5. was assigned in units of 1 point according to the stage.

As shown in Table 2, it was confirmed that Examples 1 to 5 according to the present invention received higher evaluations than Comparative Examples 1 to 3 in terms of overall improvement in scalp irritation, itching, trouble, and dandruff relief.

[Experimental Example 2] Antibacterial activity test for Malassezia furfur KCTC 7545

The strain used in this experiment was Malassezia furfur (KCTC No.7545), which was single-colonized and cultured for 48 hours at 30 ° C (degree Celsius), and then the OD value was measured. After that, the strain and the sample (Examples and Comparative Examples) were mixed, diluted 2 fold (50% to 0.39%) in 8 sections from high concentration, and cultured at 30 ° C. for 48 hours. The absorbance was measured (600 nm) using a micro plate reader equipment, and the comparison value was confirmed by repeating the experiment twice for deviation reliability. The MIC concentration in the section where the absorbance did not increase even after 48 hours compared to the initial absorbance for each sample was confirmed. The results for the growth rate of M. furfur are shown in Table 3 below.

As shown in Table 3, it was confirmed that Examples 1, 2, 3, 4, and 5 of the present invention had significantly better antibacterial activity against dandruff bacteria than Comparative Examples 1 to 3.

[Experimental Example 3] Scalp deodorization evaluation

In order to confirm the removal of scalp odor, people aged 20 to 30 years without skin disease were selected, and 20 people were selected as hair tonics to which 0.1% of each of Examples 1 to 5 and Comparative Examples 1 to 3 was applied to 20 people. It was performed once a day for 2 weeks, and the deodorizing effect satisfaction was evaluated according to the following evaluation criteria, and the average results are shown in Table 4 below.

[※ Deodorization evaluation criteria: 1: very poor, 2: poor, 3: average, 4: excellent, 5: very good]

As can be seen in Table 4, it was confirmed that the cosmetic compositions containing Examples 1 to 5 according to the present invention have excellent deodorizing effects compared to Comparative Examples 1 to 3.

[Experimental Example 4] Scalp environment improvement evaluation

After using Formulation Example 1 in the following table once for 32 women aged 20 to 59 years old, scalp keratin, scalp oil, and scalp moisture were measured, and scalp redness (sedation) and scalp blood circulation improved, scalp after 2 weeks of use Human efficacy evaluation for itch relief was conducted to confirm the following results.

1. Measuring instruments

- Scalp keratin measurement: D-squame, Visioscan VC98

- Scalp oil measurement: Sebumeter SM815

- Scalp moisture measurement: DemaLab Hydration pin probe

- Scalp itching relief measurement: Tewameter TM Nano, subject VAS evaluation

- Scalp redness (sedation) measurement: ASW300, I-Max Plus

- Scalp blood circulation measurement: Laser doppler PIM3

2. Measurement results

(1) Scalp keratin measurement (D.I., %)

After using the test product (Formulation Example 1), the scalp keratin measurement value decreased to a significant level (p<0.05) immediately after use compared to before use, confirming that scalp keratin was improved.

(2) Measurement of scalp oil (μg/cm ² )

After using the test product, the scalp oil measurement value decreased to a significant level (p<0.05) immediately after use compared to before use, confirming that scalp oil was improved.

(3) Measurement of scalp moisture (μS)

After using the test product, the scalp moisturizing measurement value increased to a significant level (p <0.05) immediately after use compared to before use, confirming that scalp moisturizing was improved.

(4) Scalp itching relief measurement

(4-1) Measurement of water loss (g/m ² h)

After using the test product, the measured value of scalp moisture loss decreased to a significant level (p<0.05) after 2 weeks of use compared to before use, confirming that scalp moisture loss was improved.

(4-2) Itch improvement evaluation (VAS)

It was confirmed that the itching improvement evaluation (VAS) score after using the test product decreased to a significant level (p<0.05) after 2 weeks of product use compared to before product use.

(5) Scalp redness (sedation) measurement (a-value)

After 2 weeks of using the test product, the measured value of scalp redness (sedation) decreased to a significant level (p<0.05) after 2 weeks of use compared to before use, confirming that it was improved.

(6) Scalp blood circulation measurement (P.U) - After 2 weeks of using the test product, the scalp blood circulation measurement value increased at a significant level (p<0.05) after 2 weeks of use compared to before use, confirming that it was improved.

[Formulation Example 1] Preparation of shampoo containing the composition of Preparation Example

Utilizing the composition according to the present invention, a shampoo was prepared. Shampoo was prepared in a conventional manner according to the formulations in Table 5 below.

Claims (7)

As a composition for improving scalp health,
The composition,
i) Palmarosa oil; ii) Piroctone Olamine; and iii) at least one of succinic acid and monoterpenes as an active ingredient,
The pyroctoneolamine is included in 10 ^-2 parts by weight to 150 parts by weight based on 100 parts by weight of Palmarosa oil,
The succinic acid is included in an amount greater than 10 ^-4 parts by weight and less than 3500 parts by weight based on 100 parts by weight of Palmarosa oil,
The monoterpenes, palmarosa oil 100 parts by weight compared to 10 ^-4 parts by weight of more than 200 parts by weight of scalp health improving composition.
delete delete According to claim 1,
The monoterpenes include terpineol, eucalyptol, ocimene, myrcene, hinokitiol, menthol, camphene, and pinene. ) Containing at least one selected from the group consisting of, a composition for improving scalp health.
According to claim 1,
The scalp health improvement composition for improving scalp health, comprising one or more of the following:
i) inhibition of scalp odor generation and alleviation of scalp odor;
ii) control of scalp sebum secretion;
iii) relief of one or more of scalp irritation, itching and trouble; and
iv) inhibiting the proliferation of dandruff bacteria or inhibiting dandruff production.
According to claim 1,
The composition is a cosmetic composition or a pharmaceutical composition,
The pharmaceutical composition is for alleviating itching of the scalp, a composition for improving scalp health.
According to claim 6,
The cosmetic composition or pharmaceutical composition,
A composition for improving scalp health comprising palmarosa oil, pyroctonolamine, succinic acid and monoterpenes in an amount of 0.05 to 5.0% by weight, based on the total weight of the composition, respectively.

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