KR20190094951A - Compositions including eriobotrya japonica extracts - Google Patents

Abstract

The present invention relates to a composition containing an extract of Eriobotrya japonica, comprising 32 to 37 wt% of the extract of Eriobotrya japonica; 12 to 17 wt% of a Kalopanax pictus extract; 12 to 17 wt% of a Sapindus mukorossi extract; 11 to 16 wt% of a Dendropanax morbiferus extract; 18 to 23 wt% of a Gleditsia sinensis extract; 0.3 to 0.7 wt% of a Ganoderma lingzhi extract; and 0.3 to 0.7 wt% of a Taxus cuspidata fruit extract. The present invention has an effect of preventing diseases and aging by developing and taking various tree extract compositions associated with a specific disease or aging.

Description

Composition comprising loquat extract {COMPOSITIONS INCLUDING ERIOBOTRYA JAPONICA EXTRACTS}

The present invention relates to a composition comprising a locust extract, and more particularly, to a composition comprising a locust extract for developing various tree extract compositions associated with a specific disease or aging.

Of the total population released in 2005 by the National Statistical Office, the proportion of the elderly aged 65 and over occupied 9.1%, and the proportion of young people aged 14 and under was gradually decreasing, and the proportion of the population aged 65 and over recorded 7.2% in 2000. It is estimated that our society has already entered an aging society. In addition, as of 2003, the average life span of Korean people is 77.5 years old, and the elderly population is rapidly increasing. Meanwhile, Korea's GNI per capita announced by the National Statistical Office was $ 14,162 in 2004, and it is increasing by more than 10% every year. Due to such changes in social conditions, the number of deaths from infectious diseases, which are the major causes of death, has been drastically decreasing, while the number of deaths from cancer, cerebrovascular diseases, and metabolic syndrome is steadily increasing.

In particular, as life expectancy increases and the aging of society progresses, interest in aging and diseases related to aging, in particular, degenerative neurological diseases related to cranial nerve cell damage, are increasing. In addition, as the incidence and mortality of metabolic syndrome increases with industrialization and dietary changes, interest in metabolic syndrome such as diabetes or obesity is increasing. In addition, as interest in free radicals, which are thought to cause aging and various diseases, has increased, interest in substances having an antioxidant effect is increasing. There are various definitions related to aging, and with regard to cell replication, the limited life span of normal somatic cells in humans, that is, no longer able to divide after limited cell division, and eventually stop the stage of growth that cannot be reversed, can be attributed to aging. (Tominaga et al., Mech.Aging Dev. 123: 927936 (2002)). Aging is associated with diseases such as neurodegenerative disease, metabolic syndrome such as cancer or diabetes mellitus, and the causes related to aging are genetic causes and accumulation of DNA damage (Sedelnikova et al., Nat. Cell Biol. 6: 168170 (2004). ), Response to oxidative stress (Campisi et al., Exp. Gerontol. 36: 607618 (2001)), and telomeres damage (Harrington and Robinson, Oncogene 21: 592597 (2002)). Living organisms have been reported to have evolutionarily conserved genetic pathways that affect the aging and longevity of an individual, and in some experimental animals genes that can determine the longevity of an individual, such as Drosophila methuselah, Indy or Sir2. And the like have been reported.

On the other hand, most living organisms are oxygen free radicals that cause severe physiological disorders due to high reactivity, because oxygen, an essential element necessary for life, is subjected to various environmental stresses caused by deterioration of the global environment as well as biological stress such as germs, pests or viruses. (reactive oxyzen species). Therefore, it is a system for removing such active oxygen species in the living body, such as superoxide dismutasse (SOD, EC 1. 15. 1.1), peroxidase (POD), catalase (CAT), etc. There are a lot of polymer antioxidant enzymes and antioxidants such as vitamin C, vitamin E or glutathione (glutathion).

Among them, superoxide dismutase (SOD) is present in almost all organisms, and has been reported to play an important role in biological defense mechanisms that eliminate free radical species.

Substances that prevent or ameliorate diseases such as metabolic syndrome and neurodegenerative diseases, in particular, those that can prevent aging of human subjects, that is, extend the lifespan or remove free radicals from the body or reactive oxygen species It is difficult to establish a method of searching for a substance that weakens the activity of.

However, recently, a method of developing a substance or an anti-aging substance for preventing or ameliorating the disease by developing a substance capable of controlling the expression of a gene associated with a specific disease or aging has been proposed. Polyphenols, such as resveratrol produced by plants in response to environmental stress, promote the activity of Sir2, increasing the lifespan of yeast replication and the life of small nematodes or fruit flies and improving human cell viability. The validity of the method has been demonstrated.

As the above validity has been proved, a substance that can regulate the expression of these genes, such as the SIRT3 gene, which is closely correlated with the lifespan of a particular disease or human individual, is developed from natural products with minimal risk of side effects. The demand is increasing.

In addition, in order to solve the problem that the duration of activity is not long, there is an increasing demand to develop a substance capable of regulating the expression of SOD capable of removing reactive oxygen species from the body from natural products with minimal risk of side effects.

In response to these demands, efforts are underway to find substances derived from natural plants that can regulate the expression of the SIRT3 gene and the SOD gene.

The present invention has been invented in order to meet the above-mentioned demands of the prior art, and to provide a composition comprising a loquat extract to develop various tree extract compositions associated with a specific disease or aging.

The composition comprising the loquat extract according to the first embodiment of the present invention, 32-37% by weight of the loquat extract, 12-17% by weight of the oak extract, 12-17% by weight of the no-tree extract, Hwangchil-tree extract 11 to 16% by weight, 18-23% by weight of the extract of engraved tree, 0.3-0.7% by weight of Ganoderma lucidum extract, 0.3-0.7% by weight of yew fruit extract.

According to the composition comprising the loquat extract of the present invention, it has the effect of preventing disease and aging by developing and taking various tree extract compositions associated with a specific disease or aging.

Hereinafter, preferred embodiments of the present invention will be described to be easily implemented by those skilled in the art. In describing the present invention, when it is determined that a detailed description of a related known function or known configuration may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted.

The terminology used herein is for the purpose of describing particular example embodiments only and is not intended to be limiting of the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this application, the terms "comprise" or "have" are intended to indicate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, and one or more other features. It is to be understood that the present invention does not exclude the possibility of the presence or the addition of numbers, steps, operations, components, components, or a combination thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art. Terms such as those defined in the commonly used dictionaries should be construed as having meanings consistent with the meanings in the context of the related art, and are not construed in ideal or excessively formal meanings unless expressly defined in this application. Do not.

Hereinafter, preferred embodiments of the present invention will be described in detail. In addition, in describing the present invention, when it is determined that the detailed description of the related known configuration or function may obscure the gist of the present invention, the detailed description thereof will be omitted.

EXAMPLE

The composition comprising the loquat extract of the present invention, 32-37% by weight of the loquat extract, 12-17% by weight of the oak extract, 12-17% by weight of the no-tree extract, and 11-16% by weight of the Hilchi chinensis extract , Engraver tree extract 18-23% by weight, Ganoderma lucidum extract 0.3-0.7% by weight, and yew tree fruit extract 0.3-0.7% by weight.

Extracts of the trees are made through the following process.

That is, the trees are felled, washed thoroughly with water, and dried in a well-ventilated shade for 5-7 days. Cut the dried tree corresponding to the volume of 5ℓ into the size of 2-3cm thick and put it in the pot containing 10ℓ jijisu water and boil at 150 ~ 180 ℃ for 42 ~ 45 hours. Boiling as described above extracts the nutrients in the tree. This extract is used by filtration.

The loquat has thick branches and dense light tan hairs with the back of the leaves. Sprigs have brown soft hairs. It is used for ornamental, edible and medicinal purposes. The fruit is sweet and sweet and contains lots of vitamins A, B, and C with sugar. The seed is called bibi and used as a substitute medicine for almonds. Remove the hair on the back of the leaf is called loquat medicinal. When used as a medicine, use it as a bath, powder, or pill.

The oak tree is a dicotyledonous plant and is a deciduous tree of the arboraceae family. It is mainly distributed in Korea, Japan, Manchuria, and China, and its size is about 25m in height. It is also called mother's silkworm or stiffwood, and depending on the region, it is also called kaleidolp. The colder the plant, the better it grows. The oak tree is usually used as a medicinal ingredient to soak liquor using the inner house or root. In oriental medicine, it is especially effective for arthritis, so it is widely used as an herbal material.

The oak tree, which is widely used as an herbal material, is very effective in arthritis. In addition, it is good for tonic, fever and fatigue. The stem of the oak tree is made of tea and eaten to make it a very healthy drink. The health drink made of this moth is especially good for tonic, fever and fatigue. The bark and bark of the oak are also used as expectorants in Korean medicine.

The bark of the oak tree is called thawing blood, which is very effective for rheumatoid spondylitis because it has a calming effect on the central nerve. It also relieves nerve and muscle pain caused by arthritis. Haedongpi, the bark of oak, is usually eaten in chicken baeksook samgyetang. Haedongpi is also said to be very good for treating neuralgia, diabetes and kidney disease in Korean medicine.

In addition, the oak tree has an effect of effectively lowering the sugar level is very good for diabetics, especially if the leaf and bark of the oak tree to continue eating it is effective in improving diabetes.

In addition, the saponin ingredient in sapwood is very good for people with cough and sputum symptoms, and it is especially effective for cough and sputum symptoms by taking the root of juice from the roots of juice. There is also.

People who do not have good liver often finds food that is very good because it has ingredients that help the liver detoxify. It also replenishes lack of energy and has digestive effects. It is said that the oak tree is often used as a treatment for patients with liver cancer, cirrhosis and liver cancer.

Om has long been used as a folk remedy for the treatment of skin, which has the effect of treating skin-related diseases such as skin diseases, ulcers and wounds.

Sapindus mukorossi is native to tropical Asia of the Amacaceae family, and it is an evergreen tree in the tropics but leaves in the cold regions. Twigs are thick, greenish brown, hairless, and crusty. Winter snow is hemispherical, 1mm long, wrapped in 4 pieces of snow scales. It grows up to 15 ~ 25m in height, blooms from June to July, and fruiting season is from September to November. It grows in the southern part of Korea, the bark is light yellowish brown, and the leaf traces are triangular, triangular to heart-shaped, and the tube bundle is three. The leaves are alternate and the pinnate leaves. The leaf is 8 ~ 16 small leaves with evenly-shaped even leafs alternately facing each other, long oval, pointed at the end, and the edge is flat. Male and female, small yellow-green flowers gather in conical at the end of branches. Male flowers have 8 stamens, and female flowers have 1 pistil. The round fruit is 20-30mm in diameter, ripened yellowish brown, and the black bead-like seed inside is 15-20mm. It is used to make beads in Buddhism, and it is said to have good fragrance when burning wood. It is said that the made needle is good.

The inner and fruit bark of the stems of the patient-free tree contains a large amount of saponin, which foams well, so in the past it was used to wash soap and fruit bark was used to wash the hair. The surface of the fruit is shiny and slightly crunchy, but when you shake it, you will hear a crunchy black seed.

Since ancient times, saponins, soap ingredients, have been used as soap substitutes when washing fruit pulp (과 手 果), which means the fruit used to wash hands.

As described above, the patient-bleeding tree hemostasis, bake and exterminate parasites, remove waste products. Decoction by making a decoction to drive out the wind sand (風邪), to reduce the swelling and discharge the poison.

Burning the patient's tree, pulverizing the ash and blowing it into the throat cures the symptoms of hoarseness.

The leaves and young leaves of the patient-free tree, which have no internal use, can be used to cure snake bites when applied to the skin at the same time.

The roots of the tree, which is the root of the tree, is said to treat colds caused by fever, cough, hemorrhage, cloudiness, and white crabs.

Hwangchil-tree, which is 15m in height and distributed in Jeolla-do, Gyeongsangnam-do, Jeju-do, and Okinawa, Japan and south of Honshu, is green without hairs. Less-grown hwangchil trees are divided into three to five and have sawtooth, which is famous for carpentry, which is used for making surfaces and for coloring. Sap is also used in woodworking. In addition, there are a lot of saponins in wild ginseng or ginseng, which is also used as a medicinal herb.

Our nerves are overheated by stress. In addition to my work, academic work, and household work, my life pattern itself is irregular, so there are many feelings of anxiety, insomnia, and depression.

In women, menstruation does not come out on time, which is quite annoying, and it is said that Hwangchil Tree helps to improve uterine disease or menstrual disorders in women, prostate inflammation, neural prostate disease, and prostatic hyperplasia in men. . In addition, it helps to cure hematuria, nocturnal enuresis, and urinary incontinence, which is a urination function disease, and helps the bladder to be healthy. It also helps people who have had prostate surgery recover.

This hwangchil wood contains a lot of ingredients in saponin ginseng, wild ginseng, this component has anti-cancer effect and is also used in clinical experiments.

This hwangchil tree helps blood circulation and normalizes cholesterol levels in the blood, which helps patients with hypertension. It is also good for diabetics because it makes blood sugar levels appropriate, and it is also helpful for blood circulation-related diseases such as numbness of hands and feet, migraine, cold hands and hands, and prevents stroke and cerebral hemorrhage.

Hwangchil wood is also good for our teeth is helpful for periodontal cells and tooth regeneration is also helpful for those concerned with tooth-related diseases. This is because bone tissue is effective in regenerating well. This helps prevent osteoporosis and also helps with rheumatoid arthritis.

Engraver is a deciduous tree belonging to the family Caesalpiniacea, growing up to 20m in height, and many large thorns of branches disappear as they grow.

These carved trees are used in medicine to dry thorns and fruits in the fall in one room, and dried sculpted carcasses (早 角 刺) improve the wind and have an insecticidal effect.

Ganoderma lucidum is a mushroom belonging to the Democratic Fungi Buloba. The taste is sweet and bitter, the property is flat and acts on the heart, rain, lungs, and cirrhosis. It has five flavors, and is said to be tonic, soothing, Shin-Ikjeong, Szabo, and shoulder bones.

These ganoderma lucidum mushrooms, blood pressure control, plasma and liver cholesterol suppression, hypoglycemia, immune enhancement, complement system and retinal system activity, anti-aging, physiological activity, cellular activity, anti-inflammatory, antibacterial, anti-allergic, antihistamine, anti-male hormone, detoxification, Blood, interpolation, diuretic [diuretic action is very strong]. Recently, it has been found that it acts to suppress the AIDS virus.

Mainly: hypertension, hypertension, hypotension, arteriosclerosis, kidney failure, stroke, forgetfulness, insomnia, gastric ulcer, sudden chronic hepatitis, nervous breakdown, arthritis, heart and gastrointestinal weakness, indigestion, constipation, Hari, abdominal pain, fever, allergy, anemia, Heart palpitations, Hanhan, pyelonephritis, pulmonary tuberculosis, chronic bronchitis, asthma, pneumonia, cold, eye disease, rhinitis, poisoning, alopecia, adult diseases, etc. It is currently used as a raw material for wool.

The yew tree, "Alive and a Thousand Years," is called a miracle anticancer drug, as it was discovered that the US BMS made an effective anticancer drug called "taxol" with the ingredient called paclitaxel extracted from its bark.

"Taxol" works by blocking blood vessels that supply nutrients to cancer cells, which is effective enough to cure terminal cancer patients when used in combination with other treatments. The leaves of the yew tree contain flavonoids, alkaloids, and coumarin, and the leaves collected in June contain 0.22% taxol.

The yew tree fruit, flavonoids, alkaloids, coumarin contains is said to be effective in various types of cough, neuralgia, pain. It also acts to lower blood pressure and is used for pain, diuresis and diabetes.

As described above, specific embodiments have been described in the detailed description of the present invention, but it is obvious that the technology of the present invention can be easily modified by those skilled in the art, and such modified embodiments are defined in the claims of the present invention. It will be included in the technical spirit described.

Claims (1)

32-37 wt% of loquat extract;
12-17% by weight of the oak extract;
12-17% by weight of the extract from the tree;
Hwangchil-tree extract with 11 to 16% by weight;
18-23% by weight of the bark extract;
Ganoderma lucidum mushroom extract 0.3-0.7% by weight and;
Yew tree fruit extract composition comprising a loquat extract, characterized in that consisting of 0.3 ~ 0.7% by weight.