KR20160111646A - Method for producing of new material for Improving GOUT, Reducing URIC Acid - Google Patents

Method for producing of new material for Improving GOUT, Reducing URIC Acid Download PDF

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Publication number
KR20160111646A
KR20160111646A KR1020150036524A KR20150036524A KR20160111646A KR 20160111646 A KR20160111646 A KR 20160111646A KR 1020150036524 A KR1020150036524 A KR 1020150036524A KR 20150036524 A KR20150036524 A KR 20150036524A KR 20160111646 A KR20160111646 A KR 20160111646A
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South Korea
Prior art keywords
gout
uric acid
improving
nuri
tree
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KR1020150036524A
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Korean (ko)
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김상민
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김상민
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • A61K36/855Clerodendrum, e.g. glorybower
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

More particularly, the present invention relates to a method for producing a composition which is effective for improving pain and complications caused by gout using plant extracts. The composition having the effect of reducing uric acid and improving the gout according to the present invention is characterized by comprising 10 to 60 parts by weight of Nuri-jinja leaf, 10 to 60 middle parts of Nuri-japonica branch, 10 to 60 middle parts of japonica leaf and 10 to 60 middle- And then concentrated and fermented.
INDUSTRIAL APPLICABILITY As described above, according to the present invention, a composition containing a novel plant extract as an active ingredient and having an effect of reducing uric acid and improving gout is effective in improving complications such as lowering of uric acid level and disappearance of gout pain.

Figure pat00003

Description

FIELD OF THE INVENTION [0001] The present invention relates to a method for producing a substance having an effect on improving gout, reducing uric acid,

Gout is caused by uric acid (uric acid is present in the form of urate in the blood, body fluids, and joint fluids) as the concentration of uric acid (the product that the body metabolizes the substance called purine) It is deposited in cartilage, tendons, and surrounding tissues of this joint.

It is a disease. This phenomenon causes inflammation of the joints, resulting in recurrent seizures accompanied by severe pain. Deformations and deformities of the joints occur when the gouty nodules (tophi) due to urate crystals are deposited. In addition to joint abnormalities, kidney disease (kidney disease) that causes kidney disease and kidney stones caused by uric acid may appear.

The higher the age and the higher the concentration of uric acid in the blood, the more likely it is to develop a gout. Uric acid is a product that is metabolized by the body, which is a substance called purine, which is ingested through food. It exists in the form of urate in blood, body fluids, and joint fluids. If the concentration of uric acid in the blood exceeds a certain level, it is called hyperuricemia. The cause is hyperuric acid production and decreased excretion of uric acid.

The resulting gout is a complication that can lead to death from kidney stones, heart disease, brain disease, etc. and can cause arthritis, elbow, knee, ankle, wrist, arm, shoulder,

The characteristics and efficacy of the compositions according to the invention are described.

Clarodendrum trichotomum, a spruce tree, a deciduous broad-leaved shrub. The height is 2-3 meters, the leaves are opposite and egg-shaped. In August, a light red flower blooms at the end of the branch with 聚 (聚) flower, and light blue berries ripen in autumn. Young leaves are edible, branches and roots are medicinal. It grows in the fertile grounds of the foothills and valleys, and it is distributed in the south of Hwanghae province, Japan, China, and Taiwan. Odori (odorous tree), odorous odor. (Clerodendron trichotomum) also called

It grows up to about 3m in height, and it adapts well to the abolished waste paper, and it has a cold resistance, a high resistance to weathering, and a very rapid growth. The tree is named after the tree is full of goodness. It is called by various names depending on the province, such as the tree, the paulownia oak, the shark tree, the kite tree, the dog tree, The beautiful fragrant flowers and unusual fruits that bloom in the flesh, and the new leaves in the early spring, are good for herbs, even though they are good for them.

Leaves and flowers, branches and roots diuretic, neuralgia treatment, is used as herbal medicine materials such as the construction.

It also contains linoleic acid and acts on the cell membrane and platelets.

The shrub is the scientific name Aucuba japonica

It is also called a blue-and-white tree. It grows in the shadow of the beach. It is about 3m in height. The new branch is green and coarse and has no hairs with leaves. Leaves are opposite, long oval or basal, 10-15cm long, and about 5cm wide. It is thick, with thick saw teeth on the edge and glossy. Petiole is 2 ~ 5cm long.

It is planted for ornamental purposes because it is resistant to insect pests and smoke, and wood is used for machine materials and leaves for food. In the private sector, bark and leaves are also used for gastritis, snakebite, boils, burns, etc. It contains aucubin and is excellent in pain and anti-inflammatory effect.

The present application is based on the present invention,

After studying the possibility of uric acid removal and improvement of gout as a raw material,

The effect was confirmed by consuming 5 substances from the Korea Employees' Association and 24 people from general affairs who suffered from gout

    If you look at how to treat gout in modern medicine

Acute gout attacks can effectively relieve symptoms by drugs such as colchicine, non-steroidal anti-inflammatory drugs, and steroids. It is important to start taking medication immediately if a gout attack occurs, because the symptoms can improve quickly and effectively when you start treatment early.

Prevention of gout attacks during intermittent periods can be very effective in preventing acute gout attacks by taking small amounts of colchicine daily. After 3 to 6 months of prophylactic use, the use of colchicine may be discontinued, but acute gout attacks may be exacerbated.

The prophylactic use of colchicine may stop the acute inflammatory response, but it does not remove uric acid crystals accumulated in the tissue, so there is the possibility of cartilage and bone destruction without warning symptoms such as acute pain.

Colchicine has been used as a special medicine for gout in the past and as a medicine for several other diseases. Recently, however, it has not been well prescribed due to side effects. A typical side effect is that the stomach gets worse and affects immune cells. Excessive use can lead to spinal problems and anemia. If you are poisoned by ingesting a large amount at one time, symptoms similar to arsenic poisoning may occur and cause symptoms such as headache, fever, vomiting, diarrhea, abdominal pain, kidney failure, and death due to dyspnea. There is no antidote.

Treatment of chronic nodular gout can be accomplished by controlling hyperuricemia using anti - hyperuricemic drugs, preventing uric acid from depositing in tissues and normalizing serum uric acid levels. Uric acid excretion promoters such as allopurinol and probenecid are mainly used.

Alloflinol is a severe variant of erythema multiforme, and its prognosis is poor, and its involvement in various organs may be variable and sometimes fatal. It is mainly seen in children and young people, and men are twice as many as women.

Provenoside <Pharmacy> One of the uric acid emission promoters. It is used to release uric acid in the body when treating chronic gout. Generally, it has little side effects, but it also stimulates digestive organs.

As mentioned above, gout therapy in modern medicine is accompanied by side effects, and most of it is recurring after a certain period of time.

The present invention is an effective composition for removing uric acid and improving gout containing an effective ingredient of a plant extract having uric acid removal and gout improving effect, and it has been confirmed that the uric acid in the body is removed to eliminate pain and improve gout.

In order to solve the problems of the conventional art, which has many side effects as described above, 10 to 60 parts by weight of a natural material having a ventilation improving effect according to the present invention, 10 to 60 branches of a Nuri-japonica branch, 10 to 60 branches 10 to 60 walnut branches, and 10 to 60 walnut branches are extracted with water at a temperature of 90 to 100 ° C under normal pressure for 2 to 10 times or more for 1 to 24 hours or under supercritical extraction at a pressure of 0.5 to 1.0 kgf / Bacillus bifidum may be cultivated alone in the above extract or in the presence of Bacillus bifidum and Lactobacillus acidophilus or Bacillus acidophilus in order to increase the water content by 40% to 20% Bifidum and L. bulgaricus are mixed and then fermented at 25 to 37 DEG C for 8 to 168 hours or more.

The characteristics and efficacy of the compositions according to the present invention will be further explained.

Clarodendrum trichotomum, a spruce tree, a deciduous broad-leaved shrub. The height is 2-3 meters, the leaves are opposite and egg-shaped. In August, a light red flower blooms at the end of the branch with 聚 (聚) flower, and light blue berries ripen in autumn. Young leaves are edible, branches and roots are medicinal. It grows in the fertile grounds of the foothills and valleys, and it is distributed in the south of Hwanghae province, Japan, China, and Taiwan. Odori (odorous tree), odorous odor. (Clerodendron trichotomum) also called

It grows up to about 3m in height, and it adapts well to the abolished waste paper, and it has a cold resistance, a high resistance to weathering, and a very rapid growth. The tree is named after the tree, which is said to be very tender throughout the tree. It is called by various names depending on the province, such as the tree, the dung, the shark tree, the kite tree, the dog tree, The beautiful fragrant flowers and unusual fruits that bloom in the flesh, and the new leaves in the early spring, are good for herbs, even though they are good for them.

Leaves and flowers, branches and roots diuretic, neuralgia treatment, is used as herbal medicine materials such as the construction.

It also contains linoleic acid and acts on the cell membrane and platelets.

The shrub is the scientific name Aucuba japonica

It is also called a blue-and-white tree. It grows in the shadow of the beach. It is about 3m in height. The new branch is green and coarse and has no hairs with leaves. Leaves are opposite, long oval or basal, 10-15cm long, and about 5cm wide. It is thick, with thick saw teeth on the edge and glossy. Petiole is 2 ~ 5cm long.

It is planted for ornamental purposes because it is resistant to insect pests and smoke, and wood is used for machine materials and leaves for food. In the private sector, bark and leaves are also used for gastritis, snakebite, boils, burns, etc. It contains aucubin and is excellent in pain and anti-inflammatory effect.

The present application is based on the present invention,

After studying the possibility of uric acid removal and improvement of gout as a raw material,

The effect was confirmed by consuming 5 substances from the Korea Employees' Association and 24 people from general affairs who suffered from gout

As described above, according to the present invention,

It is effective for the improvement of the accompanying diseases caused by gout and gout such as decreased uric acid level.

Processes for reducing uric acid and improving ventilation.

 In order to achieve the above object,

 Reduction of uric acid, including Nuri-japonica branches,

 Provided is a method for producing a substance effective for improving the ventilation.

 In the above, the Nuri pollen, Nuri pollen,

 Refers to edible raw materials.

        In the present invention, as described above, in the edible plant,

        Extract hot water and ferment it to reduce uric acid and produce gout improving substance.

        And the embodiments described below are merely illustrative of the scope of the present invention

        But is not limited to.

        (Example 1) 1,400 g of Nuri-jinja leaf, 1,000 g of Nuri-japonica branch, 1,400 g of pine tree,

        Put 1000g of the edible sprout branches together in a hot water pot, add 5 liters of total solids 5 liters

        Water was added and heated at 100 DEG C or higher for 9 hours to obtain a hot water extract

        4.8 liters of hot water extraction was obtained (see Table 1).

        The resultant was given to 17 patients with gout for 80 days three times a day for 30 days

        The improvement effect was observed with the paperweight. (See Table 2)

        (Example 2) The result of (Example 1) was concentrated to 40% of water

        500 g of the product was obtained, and Bacillus bifidum was inoculated at 37 캜

        It was fermented for 18 hours and made into a ring.

        3 times a day for 30 days while eating the paper improvement effect was observed.

        (See Table 3)


Raw materials

Composition ratio
Nuri Tang 29.17 Nuri Tang Branch 20.83 Sour tree 29.17 Tree branch 20.83

Figure pat00001

Figure pat00002

Claims (3)

To obtain substances with reduced uric acid and improved gout, Nuri pollen 10 ~ 60
Weight part, Nuri tang branch 10 ~ 60 middle part, ficus leaf 10 ~ 60 middle part
10 to 60 branches of the japonica tree are mixed with 2 to 10 times of water at 90 ° C to 100 ° C
Production method of hot water extraction for 1 hour ~ 24 hours

To obtain substances with reduced uric acid and improved gout,
10 to 60 parts by weight, 10 to 60 mulberry branches, 10 to 60 mulberry leaves
Supercritical extraction was carried out under pressure of 0.5 ~ 1.0kgf /
Or from 110 to 120 캜.
To obtain substances with uric acid reduction and gout improvement
3. The method according to claim 1 or 2, wherein
After concentrating to a moisture content of 40% to 20%, Bacillus bifidum
Culturing alone or cultivating Bacillus bifidum and Lactobacillus acidophilus (L. acidophilus)
Or a mixture of Bacillus bifidum and L. bulgaricus
Followed by fermentation at 25 to 37 占 폚 for 8 hours to 168 hours or longer to obtain a substance.
KR1020150036524A 2015-03-17 2015-03-17 Method for producing of new material for Improving GOUT, Reducing URIC Acid KR20160111646A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101849301B1 (en) * 2018-01-29 2018-04-16 전북대학교 산학협력단 Composition for treatment and prevention of dry eye syndrome comprising Aucuba japonica extract

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101849301B1 (en) * 2018-01-29 2018-04-16 전북대학교 산학협력단 Composition for treatment and prevention of dry eye syndrome comprising Aucuba japonica extract
WO2019146881A1 (en) * 2018-01-29 2019-08-01 전북대학교산학협력단 Composition for preventing or treating dry eye syndrome, containing aucuba japonica extract
JP2021517557A (en) * 2018-01-29 2021-07-26 全北大学校産学協力団Industrial Cooperation Foundation Chonbuk National University Composition for prevention or treatment of xerophthalmia containing Aoki extract

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