KR20160111646A - Method for producing of new material for Improving GOUT, Reducing URIC Acid - Google Patents
Method for producing of new material for Improving GOUT, Reducing URIC Acid Download PDFInfo
- Publication number
- KR20160111646A KR20160111646A KR1020150036524A KR20150036524A KR20160111646A KR 20160111646 A KR20160111646 A KR 20160111646A KR 1020150036524 A KR1020150036524 A KR 1020150036524A KR 20150036524 A KR20150036524 A KR 20150036524A KR 20160111646 A KR20160111646 A KR 20160111646A
- Authority
- KR
- South Korea
- Prior art keywords
- gout
- uric acid
- improving
- nuri
- tree
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
More particularly, the present invention relates to a method for producing a composition which is effective for improving pain and complications caused by gout using plant extracts. The composition having the effect of reducing uric acid and improving the gout according to the present invention is characterized by comprising 10 to 60 parts by weight of Nuri-jinja leaf, 10 to 60 middle parts of Nuri-japonica branch, 10 to 60 middle parts of japonica leaf and 10 to 60 middle- And then concentrated and fermented.
INDUSTRIAL APPLICABILITY As described above, according to the present invention, a composition containing a novel plant extract as an active ingredient and having an effect of reducing uric acid and improving gout is effective in improving complications such as lowering of uric acid level and disappearance of gout pain.
Description
Gout is caused by uric acid (uric acid is present in the form of urate in the blood, body fluids, and joint fluids) as the concentration of uric acid (the product that the body metabolizes the substance called purine) It is deposited in cartilage, tendons, and surrounding tissues of this joint.
It is a disease. This phenomenon causes inflammation of the joints, resulting in recurrent seizures accompanied by severe pain. Deformations and deformities of the joints occur when the gouty nodules (tophi) due to urate crystals are deposited. In addition to joint abnormalities, kidney disease (kidney disease) that causes kidney disease and kidney stones caused by uric acid may appear.
The higher the age and the higher the concentration of uric acid in the blood, the more likely it is to develop a gout. Uric acid is a product that is metabolized by the body, which is a substance called purine, which is ingested through food. It exists in the form of urate in blood, body fluids, and joint fluids. If the concentration of uric acid in the blood exceeds a certain level, it is called hyperuricemia. The cause is hyperuric acid production and decreased excretion of uric acid.
The resulting gout is a complication that can lead to death from kidney stones, heart disease, brain disease, etc. and can cause arthritis, elbow, knee, ankle, wrist, arm, shoulder,
The characteristics and efficacy of the compositions according to the invention are described.
Clarodendrum trichotomum, a spruce tree, a deciduous broad-leaved shrub. The height is 2-3 meters, the leaves are opposite and egg-shaped. In August, a light red flower blooms at the end of the branch with 聚 (聚) flower, and light blue berries ripen in autumn. Young leaves are edible, branches and roots are medicinal. It grows in the fertile grounds of the foothills and valleys, and it is distributed in the south of Hwanghae province, Japan, China, and Taiwan. Odori (odorous tree), odorous odor. (Clerodendron trichotomum) also called
It grows up to about 3m in height, and it adapts well to the abolished waste paper, and it has a cold resistance, a high resistance to weathering, and a very rapid growth. The tree is named after the tree is full of goodness. It is called by various names depending on the province, such as the tree, the paulownia oak, the shark tree, the kite tree, the dog tree, The beautiful fragrant flowers and unusual fruits that bloom in the flesh, and the new leaves in the early spring, are good for herbs, even though they are good for them.
Leaves and flowers, branches and roots diuretic, neuralgia treatment, is used as herbal medicine materials such as the construction.
It also contains linoleic acid and acts on the cell membrane and platelets.
The shrub is the scientific name Aucuba japonica
It is also called a blue-and-white tree. It grows in the shadow of the beach. It is about 3m in height. The new branch is green and coarse and has no hairs with leaves. Leaves are opposite, long oval or basal, 10-15cm long, and about 5cm wide. It is thick, with thick saw teeth on the edge and glossy. Petiole is 2 ~ 5cm long.
It is planted for ornamental purposes because it is resistant to insect pests and smoke, and wood is used for machine materials and leaves for food. In the private sector, bark and leaves are also used for gastritis, snakebite, boils, burns, etc. It contains aucubin and is excellent in pain and anti-inflammatory effect.
The present application is based on the present invention,
After studying the possibility of uric acid removal and improvement of gout as a raw material,
The effect was confirmed by consuming 5 substances from the Korea Employees' Association and 24 people from general affairs who suffered from gout
If you look at how to treat gout in modern medicine
Acute gout attacks can effectively relieve symptoms by drugs such as colchicine, non-steroidal anti-inflammatory drugs, and steroids. It is important to start taking medication immediately if a gout attack occurs, because the symptoms can improve quickly and effectively when you start treatment early.
Prevention of gout attacks during intermittent periods can be very effective in preventing acute gout attacks by taking small amounts of colchicine daily. After 3 to 6 months of prophylactic use, the use of colchicine may be discontinued, but acute gout attacks may be exacerbated.
The prophylactic use of colchicine may stop the acute inflammatory response, but it does not remove uric acid crystals accumulated in the tissue, so there is the possibility of cartilage and bone destruction without warning symptoms such as acute pain.
Colchicine has been used as a special medicine for gout in the past and as a medicine for several other diseases. Recently, however, it has not been well prescribed due to side effects. A typical side effect is that the stomach gets worse and affects immune cells. Excessive use can lead to spinal problems and anemia. If you are poisoned by ingesting a large amount at one time, symptoms similar to arsenic poisoning may occur and cause symptoms such as headache, fever, vomiting, diarrhea, abdominal pain, kidney failure, and death due to dyspnea. There is no antidote.
Treatment of chronic nodular gout can be accomplished by controlling hyperuricemia using anti - hyperuricemic drugs, preventing uric acid from depositing in tissues and normalizing serum uric acid levels. Uric acid excretion promoters such as allopurinol and probenecid are mainly used.
Alloflinol is a severe variant of erythema multiforme, and its prognosis is poor, and its involvement in various organs may be variable and sometimes fatal. It is mainly seen in children and young people, and men are twice as many as women.
Provenoside <Pharmacy> One of the uric acid emission promoters. It is used to release uric acid in the body when treating chronic gout. Generally, it has little side effects, but it also stimulates digestive organs.
As mentioned above, gout therapy in modern medicine is accompanied by side effects, and most of it is recurring after a certain period of time.
The present invention is an effective composition for removing uric acid and improving gout containing an effective ingredient of a plant extract having uric acid removal and gout improving effect, and it has been confirmed that the uric acid in the body is removed to eliminate pain and improve gout.
In order to solve the problems of the conventional art, which has many side effects as described above, 10 to 60 parts by weight of a natural material having a ventilation improving effect according to the present invention, 10 to 60 branches of a Nuri-japonica branch, 10 to 60 branches 10 to 60 walnut branches, and 10 to 60 walnut branches are extracted with water at a temperature of 90 to 100 ° C under normal pressure for 2 to 10 times or more for 1 to 24 hours or under supercritical extraction at a pressure of 0.5 to 1.0 kgf / Bacillus bifidum may be cultivated alone in the above extract or in the presence of Bacillus bifidum and Lactobacillus acidophilus or Bacillus acidophilus in order to increase the water content by 40% to 20% Bifidum and L. bulgaricus are mixed and then fermented at 25 to 37 DEG C for 8 to 168 hours or more.
The characteristics and efficacy of the compositions according to the present invention will be further explained.
Clarodendrum trichotomum, a spruce tree, a deciduous broad-leaved shrub. The height is 2-3 meters, the leaves are opposite and egg-shaped. In August, a light red flower blooms at the end of the branch with 聚 (聚) flower, and light blue berries ripen in autumn. Young leaves are edible, branches and roots are medicinal. It grows in the fertile grounds of the foothills and valleys, and it is distributed in the south of Hwanghae province, Japan, China, and Taiwan. Odori (odorous tree), odorous odor. (Clerodendron trichotomum) also called
It grows up to about 3m in height, and it adapts well to the abolished waste paper, and it has a cold resistance, a high resistance to weathering, and a very rapid growth. The tree is named after the tree, which is said to be very tender throughout the tree. It is called by various names depending on the province, such as the tree, the dung, the shark tree, the kite tree, the dog tree, The beautiful fragrant flowers and unusual fruits that bloom in the flesh, and the new leaves in the early spring, are good for herbs, even though they are good for them.
Leaves and flowers, branches and roots diuretic, neuralgia treatment, is used as herbal medicine materials such as the construction.
It also contains linoleic acid and acts on the cell membrane and platelets.
The shrub is the scientific name Aucuba japonica
It is also called a blue-and-white tree. It grows in the shadow of the beach. It is about 3m in height. The new branch is green and coarse and has no hairs with leaves. Leaves are opposite, long oval or basal, 10-15cm long, and about 5cm wide. It is thick, with thick saw teeth on the edge and glossy. Petiole is 2 ~ 5cm long.
It is planted for ornamental purposes because it is resistant to insect pests and smoke, and wood is used for machine materials and leaves for food. In the private sector, bark and leaves are also used for gastritis, snakebite, boils, burns, etc. It contains aucubin and is excellent in pain and anti-inflammatory effect.
The present application is based on the present invention,
After studying the possibility of uric acid removal and improvement of gout as a raw material,
The effect was confirmed by consuming 5 substances from the Korea Employees' Association and 24 people from general affairs who suffered from gout
As described above, according to the present invention,
It is effective for the improvement of the accompanying diseases caused by gout and gout such as decreased uric acid level.
Processes for reducing uric acid and improving ventilation.
In order to achieve the above object,
Reduction of uric acid, including Nuri-japonica branches,
Provided is a method for producing a substance effective for improving the ventilation.
In the above, the Nuri pollen, Nuri pollen,
Refers to edible raw materials.
In the present invention, as described above, in the edible plant,
Extract hot water and ferment it to reduce uric acid and produce gout improving substance.
And the embodiments described below are merely illustrative of the scope of the present invention
But is not limited to.
(Example 1) 1,400 g of Nuri-jinja leaf, 1,000 g of Nuri-japonica branch, 1,400 g of pine tree,
Put 1000g of the edible sprout branches together in a hot water pot, add 5 liters of total solids 5 liters
Water was added and heated at 100 DEG C or higher for 9 hours to obtain a hot water extract
4.8 liters of hot water extraction was obtained (see Table 1).
The resultant was given to 17 patients with gout for 80 days three times a day for 30 days
The improvement effect was observed with the paperweight. (See Table 2)
(Example 2) The result of (Example 1) was concentrated to 40% of water
500 g of the product was obtained, and Bacillus bifidum was inoculated at 37 캜
It was fermented for 18 hours and made into a ring.
3 times a day for 30 days while eating the paper improvement effect was observed.
(See Table 3)
Raw materials
Composition ratio
Claims (3)
Weight part, Nuri tang branch 10 ~ 60 middle part, ficus leaf 10 ~ 60 middle part
10 to 60 branches of the japonica tree are mixed with 2 to 10 times of water at 90 ° C to 100 ° C
Production method of hot water extraction for 1 hour ~ 24 hours
10 to 60 parts by weight, 10 to 60 mulberry branches, 10 to 60 mulberry leaves
Supercritical extraction was carried out under pressure of 0.5 ~ 1.0kgf /
Or from 110 to 120 캜.
3. The method according to claim 1 or 2, wherein
After concentrating to a moisture content of 40% to 20%, Bacillus bifidum
Culturing alone or cultivating Bacillus bifidum and Lactobacillus acidophilus (L. acidophilus)
Or a mixture of Bacillus bifidum and L. bulgaricus
Followed by fermentation at 25 to 37 占 폚 for 8 hours to 168 hours or longer to obtain a substance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150036524A KR20160111646A (en) | 2015-03-17 | 2015-03-17 | Method for producing of new material for Improving GOUT, Reducing URIC Acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150036524A KR20160111646A (en) | 2015-03-17 | 2015-03-17 | Method for producing of new material for Improving GOUT, Reducing URIC Acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160111646A true KR20160111646A (en) | 2016-09-27 |
Family
ID=57101196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020150036524A KR20160111646A (en) | 2015-03-17 | 2015-03-17 | Method for producing of new material for Improving GOUT, Reducing URIC Acid |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20160111646A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101849301B1 (en) * | 2018-01-29 | 2018-04-16 | 전북대학교 산학협력단 | Composition for treatment and prevention of dry eye syndrome comprising Aucuba japonica extract |
| WO2023008879A1 (en) * | 2021-07-27 | 2023-02-02 | 주식회사 제노포커스 | Combined use of aucuba japonica extract and superoxide dismutase and/or bacillus strain spore in composition for improving oral health |
-
2015
- 2015-03-17 KR KR1020150036524A patent/KR20160111646A/en not_active Application Discontinuation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101849301B1 (en) * | 2018-01-29 | 2018-04-16 | 전북대학교 산학협력단 | Composition for treatment and prevention of dry eye syndrome comprising Aucuba japonica extract |
| WO2019146881A1 (en) * | 2018-01-29 | 2019-08-01 | 전북대학교산학협력단 | Composition for preventing or treating dry eye syndrome, containing aucuba japonica extract |
| JP2021517557A (en) * | 2018-01-29 | 2021-07-26 | 全北大学校産学協力団Ｉｎｄｕｓｔｒｉａｌ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ Ｃｈｏｎｂｕｋ Ｎａｔｉｏｎａｌ Ｕｎｉｖｅｒｓｉｔｙ | Composition for prevention or treatment of xerophthalmia containing Aoki extract |
| US11938162B2 (en) | 2018-01-29 | 2024-03-26 | Industrial Cooperation Foundation Chonbuk National University | Composition for preventing or treating dry eye syndrome, containing Aucuba japonica extract |
| WO2023008879A1 (en) * | 2021-07-27 | 2023-02-02 | 주식회사 제노포커스 | Combined use of aucuba japonica extract and superoxide dismutase and/or bacillus strain spore in composition for improving oral health |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kumar et al. | Recent trends in potential traditional Indian herbs Emblica officinalis and its medicinal importance | |
| KR20110112231A (en) | Fermentation method using medicinal leaf and skin external composition containing fermented extract by the method | |
| KR101431417B1 (en) | The method of oriental composite for treatment of atopy and cancer | |
| KR101024429B1 (en) | Composition for feed for poultry comprising oriental herb | |
| KR20160111646A (en) | Method for producing of new material for Improving GOUT, Reducing URIC Acid | |
| Divya et al. | Ethnopharmacological studies on the medicinal plants used By Kani Tribes of Thachamalai hill, Kanyakumari, Tamilnadu, India | |
| KR20160147424A (en) | An enzyme composition for treating metabolic disorders including extracts wasong | |
| KR100682045B1 (en) | Herbal extract for preventing and treating hepatic fibrosis | |
| Singh et al. | Medicinal importance of unexploited vegetable under North Eastern regions of India | |
| Shil et al. | Indigenous knowledge on healthcare practices by the Reang tribe of Dhalai District of Tripura, North East India | |
| KR20110091959A (en) | Anhydrous lactobacillus fermentation health function food composition with cancer curing improvements and its preparation method | |
| KR20070097386A (en) | Manufacturing method of low-salt soybean paste which adds mushroom and angelica-gigas-nakai | |
| KR100778942B1 (en) | Fomitopsis pinicola Extract Having Anti-Inflammatory Effect and The Use Thereof | |
| KR20200101169A (en) | Method of making fermented food using pine cone | |
| KR20130100438A (en) | Skin diseases drug therapy and its manufacturing method | |
| KR102651344B1 (en) | Food composition for anti-inflammatory, muscle building, joint health and cartilage health improvement | |
| KR102157138B1 (en) | Composition for preventing and treating arthritis comprising extract of juniperus rigida | |
| KR20030079289A (en) | The carbonated soft drinks a manufacturing process and a composition of ling indigestion hangover cures. | |
| KR20190044734A (en) | Composition for treating high blood pressure | |
| Srivastav et al. | MEDICINAL FOOD PLANTS OF MAND7UR | |
| CN106977300A (en) | A kind of Yellow Fructus Gardeniae special complex fertilizer and preparation method thereof | |
| KR20180135334A (en) | Production method of aged tea using green tea leaves | |
| Soni et al. | Medicinal value of [Morus alba] mulberry plant | |
| Qizi | Biology of Aloe Plant, Its Importance in Home Cultivation and Folk Medicine | |
| Sheridan | Slave Medicine in Jamaica: Thomas Thistlewood's" Receipts for a Physick," 1750-1786 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |