KR20190078646A - 디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체 - Google Patents

디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체 Download PDF

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KR20190078646A
KR20190078646A KR1020197016983A KR20197016983A KR20190078646A KR 20190078646 A KR20190078646 A KR 20190078646A KR 1020197016983 A KR1020197016983 A KR 1020197016983A KR 20197016983 A KR20197016983 A KR 20197016983A KR 20190078646 A KR20190078646 A KR 20190078646A
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alkyl
fluorophenyl
chlorophenyl
synthesis
carboxamide
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Inventor
동-밍 쉔
토마스 에이치. 그레이엄
웬쉥 리우
클레어 투지
안드레아스 베라스
진롱 지앙
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머크 샤프 앤드 돔 코포레이션
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    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/42—Oxazoles
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    • A61K31/433—Thidiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020197016983A 2016-11-18 2017-11-13 디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체 Withdrawn KR20190078646A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424066P 2016-11-18 2016-11-18
US62/424,066 2016-11-18
PCT/US2017/061223 WO2018093696A1 (en) 2016-11-18 2017-11-13 Indazole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2

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US (1) US11104690B2 (cg-RX-API-DMAC10.html)
EP (1) EP3541374B1 (cg-RX-API-DMAC10.html)
JP (1) JP2020502058A (cg-RX-API-DMAC10.html)
KR (1) KR20190078646A (cg-RX-API-DMAC10.html)
CN (1) CN110121341A (cg-RX-API-DMAC10.html)
AU (1) AU2017360939B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019010164A2 (cg-RX-API-DMAC10.html)
CA (1) CA3043203A1 (cg-RX-API-DMAC10.html)
MA (1) MA46856A (cg-RX-API-DMAC10.html)
MX (1) MX2019005786A (cg-RX-API-DMAC10.html)
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CA3043203A1 (en) 2018-05-24
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US11104690B2 (en) 2021-08-31
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