KR20190046524A - Cosmetic composition with Camellia Japonica Seed Oil aminopropanedi amides/esters - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin moisturizing which can exhibit effects such as an increase in the skin moisture content and a decrease in transepidermal water loss. The cosmetic composition comprising Camellia japonica seed oil aminopropanediol amides/esters of the present invention has an excellent effect on moisturizing the skin and ameliorating the dry skin.

Description

[0001] The present invention relates to a cosmetic composition containing Camellia japonica oil aminopropanediol amide / ester,

The present invention relates to a cosmetic composition, and more particularly, to a cosmetic composition for skin moisturizing which can impart effects such as an increase in the skin moisture content and a reduction in the water hardness loss.

Dry skin is a common condition in skin diseases or normal skin such as atopic dermatitis, juvenile and senile pruritus. Dry skin is known to be caused by impaired skin barrier function that is formed by stratum corneum lipid. Skin dryness results in no oil on the skin, keratinization, and itching symptoms.

There are various kinds of skin aging due to skin stress due to various stress and environmental pollution generated from social activities, frequent cleansing according to make-up habit, and aging due to an artificial temperature control of cold / Due to the cause, the skin becomes dry and rough due to a decrease in the water content of the stratum corneum, and the skin appears to be dull and dull, so that a need for a skin moisturizing agent is increasing.

On the other hand, it is known that maintaining the moisture content of the skin is very important in order to keep the skin elastic and smooth. When the moisture content of the skin stratum corneum is lowered, the protective function by external stimuli is weakened, and the skin becomes rough and the flexibility becomes poor. As described above, since moisturization and maintenance of dry skin is an important factor in skin care, it is necessary to develop a cosmetic composition to which raw materials such as natural plants and oils excellent in moisturizing the skin are added.

Korean Patent No. 10-07082360000 (Registered on Apr. 4, 2007) discloses a technique for a cosmetic composition containing a camphor flower extract having a skin astringent effect. Korean Patent Registration No. 10-17815890000 (Registration Date: Sep. 19, 2017) discloses a technique for a cosmetic composition containing an enzyme reaction composition of vegetable oil.

The present invention is to provide a cosmetic composition for moisturizing the skin that exhibits an effect such as skin moisturization maintenance and light skin skin moisture loss improvement using camellia seed oil.

The present invention provides a cosmetic composition for skin moisturizing, which comprises Camellia Japonica Seed Oil Aminopropanediol Amides / Esters as an active ingredient.

Camellia japonica Seed Oil Aminopropanediol Amides / Esters of the present invention can be produced by mixing camellia japonica seed oil and 3-amino-1,2-propanediol (3-amino- 2-propanediol) and reacted with Novozym 435 enzyme.

In the cosmetic composition for moisturizing the skin of the present invention, the cambocyanine oil aminopropanediol amide / ester is preferably contained in an amount of 0.10 to 80% by weight based on the whole cosmetic composition.

In the cosmetic composition for moisturizing the skin of the present invention, the skin moisturization may be preferably due to prevention of the light skin moisture loss.

In the cosmetic composition for moisturizing the skin of the present invention, the cosmetic composition may preferably be free of skin irritation.

The cosmetic composition containing the camellia seed oil aminopropanediol amide / ester of the present invention exerts an excellent effect for moisturizing the skin and has an excellent effect for improving dry skin.

Fig. 1 shows changes in the skin moisture content according to the use of the nutritive cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2.
Fig. 2 shows the changes in the amount of moisture loss of skin surface skin caused by use of the nutritional cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2.
FIG. 3 is a graph showing the result of the amount of water-loss of the skin according to the use of the nutritional cream prepared according to the prescription composition of Example 1. FIG.
FIG. 4 is a graph showing the result of the amount of water loss of the skin caused by the use of the essence prepared by the prescription composition of Example 2. FIG.
Fig. 5 shows evaluation of the skin adverse reaction according to the use of the nutritional cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2.
Fig. 6 shows the temperature stability (separation, discoloration and decoloration) of the nutritional cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2 according to temperature.

The present invention provides a cosmetic composition for skin moisturizing, which comprises Camellia Japonica Seed Oil Aminopropanediol Amides / Esters as an active ingredient.

Camellia japonica Seed Oil Aminopropanediol Amides / Esters of the present invention can be produced by mixing camellia japonica seed oil and 3-amino-1,2-propanediol (3-amino- 2-propanediol) and reacted with Novozym 435 enzyme.

Novozym 435 (Novozym 435) enzyme is a commercial enzyme available from Novozymes. In the present invention, this enzyme is used to prepare camellia seed oil aminopropanediol amide / ester. Conditions for the reaction of the enzyme may be those recommended by the Novozymes.

The camellia seed oil aminopropanediol amide / ester of the present invention contains an analogue of ceramide, a precursor thereof and a long-chain unsaturated fatty acid monoglyceride compound, which are essential constituents of intercellular lipids as well as useful ingredients derived from camellia seed oil , Excellent skin moisturizing effect and skin barrier strengthening effect can be exhibited.

In the cosmetic composition for moisturizing the skin of the present invention, the cambocyanine oil aminopropane diol amide / ester is preferably contained in an amount of 0.10 to 80% by weight based on the whole cosmetic composition.

On the other hand, the cosmetic composition for skin moisturizing of the present invention exhibits the skin moisturizing ability by exhibiting the effect of preventing the light-to-surface moisture loss. Light-to-surface moisture loss is a numerical value of how much moisture is lost by a skin barrier present in the stratum corneum that constitutes the outermost layer of the skin. The more the skin that lost moisture, the higher the water loss and the less the water loss, the lower the water loss. The Camellia Japonica Seed Oil Aminopropanediol Amides / Esters of the present invention exerted an excellent inhibitory effect on the water-surface moisture loss by the following experiment.

On the other hand, the cosmetic composition for skin moisturizing of the present invention shows no skin irritation in the following experiment, and has an advantage of not causing skin trouble in actual use. In fact, many artificial compounds have a problem of causing skin irritation and the like even though they exhibit a useful skin moisturizing effect. However, the use of Camellia Japonica Seed Oil Aminopropanediol Amides / Esters ) Showed no skin irritation and was found to be unrestricted in use.

On the other hand, in the cosmetic composition for improving skin moisture content of the skin according to the present invention, it is preferable that the cambocyanine oil aminopropanediol amide / ester is contained in an amount of 0.10 to 80% by weight based on the whole cosmetic composition. When camphor seed oil aminopropanediol amide / ester is added in an amount of less than 0.10% by weight, the effect of improving the skin moisturizing and light-to-surface moisture loss due to the camphor seed oil aminopropane diol amide / ester contained in the cosmetic composition is not sufficiently exhibited There is a concern. In addition, when the camphor seed oil aminopropanediol amide / ester is added in an amount exceeding 80% by weight, even if the content of the camphor seed oil aminopropane diol amide / ester is increased in the cosmetic composition, The skin moisturizing effect and the effect of reducing the water-loss of the hard-surface skin may not be further promoted and the formulation can not be maintained because the content of the sustained-release formulation is exceeded, so that when the formulation is contained in large amounts, the formulation is collapsed, There is a concern.

On the other hand, according to one embodiment of the present invention, the cosmetic composition of the present invention can be produced as a formulation of an underwater type emulsion, and can be produced in any other form conventionally produced in the art. For example, be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray But it is not limited thereto. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritive cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, and a cleansing water.

Hereinafter, the present invention will be described in more detail with reference to the following Examples and Experimental Examples. However, the scope of the present invention is not limited to the following embodiments and experimental examples, and includes modifications of equivalent technical ideas. Also, throughout the description of the present invention, when a component is referred to as " comprising ", it means that it can include other components, do.

[ Manufacturing example  One: Camellia seed oil Aminopropane diol Amide / Ester Camellia Japonica  Seed Oil Aminopropanediol Amides / Esters)

118 g of camellia oil and 18.2 g of 3-amino-1,2-propanediol (Sigma, MW = 91.11) were placed in a glass reactor and 100 ml of tert-butanol was added thereto as a solvent After 3.0 g of enzyme (Novozym 435, Novo) was added, the reaction was allowed to proceed for 24 hours while shaking at 55 ° C. After confirming that the spot of the oil part completely disappeared through the TLC confirmation test after the reaction, The mixture was stirred at 50 DEG C for 30 minutes and then allowed to stand at 10 DEG C or lower for 4 hours.The aqueous layer was separated and washed twice and the residue was distilled at 60 DEG C under vacuum (Hereinafter referred to as " camellia oil aminopropanediol amide / ester ") of vegetable oil and 3-amino-1,2-propanediol, ≪ / RTI >

[ Example  1: nutrition cream]

Nourishing cream prescription composition
No.
Korean Standardization Name
function Content% (W / W) Production Example 1 One Purified water Solvent Balance
2 Camellia seed oil Aminopropanediol amide / ester
Skin-Conditioning Agent
2.00 3 Butylene glycol Humectant 5.00 4 Hydrogenated lecithin Skin-Conditioning Agent 5.00 5 Methyl propanediol Solvent 5.00 6 Caprylic / capric triglyceride Emollient 5.00 7 glycerin Humectant 3.00 8 Isononyl isononanoate Emollient 3.00 9 Cyclopentasiloxane Emollient 3.00 10 Cyclohexasiloxane Emollient 1.00 11 Jojoba seed oil Skin-Conditioning Agent 1.00 12 Cetearyl alcohol Emulsifier 1.00 13 Cetearyl olivate Emulsifier 0.60
14 Hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer Viscosity Increasing Agent
0.60 15 Squalane Emollient 0.40 16 Sorbitol rebate Emulsifier 0.40 17 Benzyl glycol Solvent 0.40 18 Polysorbate 60 Surfactant 0.10 19 Ethylhexyl glycerin Skin-Conditioning Agent 0.10 20 Raspberry ketone Skin-Conditioning Agent 0.10 21 Sodium hyaluronate Skin-Conditioning Agent 0.10 22 Tocopheryl acetate Skin-Conditioning Agent 0.10 23 The disodium Chelating Agent 0.02 24 1,2-hexanediol Solvent 0.10 25 Spices Fragrance Suitable amount

[Example 2: Essence]

Essence prescription composition
No.
Korean Standardization Name
function Content% (W / W) Production Example 1 One Purified water Solvent Balance
2 Camellia seed oil Aminopropanediol amide / ester
Skin-Conditioning Agent
2.00 3 Butylene glycol Humectant 5.00 4 Hydrogenated lecithin Skin-Conditioning Agent 5.00 5 Methyl propanediol Solvent 5.00 6 glycerin Humectant 3.00 7 Benzyl glycol Solvent 0.40 8 Cyclopentasiloxane Emollient 0.40 9 Cetearyl alcohol Emulsifier 0.30 10 Isononyl isononanoate Emollient 0.30 11 Caprylic / capric triglyceride Emollient 0.30 12 Cetearyl olivate Emulsifier 0.30
13 Hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer Viscosity Increasing Agent
0.20 14 Sorbitol rebate Emulsifier 0.20 15 Cyclohexasiloxane Emollient 0.20 16 Jojoba seed oil Skin-Conditioning Agent 0.10 17 Squalane Emollient 0.10 18 Polysorbate 60 Surfactant 0.10 19 Ethylhexyl glycerin Skin-Conditioning Agent 0.10 20 Raspberry ketone Skin-Conditioning Agent 0.10 21 Sodium hyaluronate Skin-Conditioning Agent 0.10 22 1,2-hexanediol Solvent 0.10 23 The disodium Chelating Agent 0.02 24 Tocopheryl acetate Skin-Conditioning Agent 0.10 25 Spices Fragrance Suitable amount

[ Experimental Example  1: skin Moisture power  Check effect]

For the above Examples 1 and 2, 20 adult women aged 19 to 60 years who had no skin disease that would affect the results of the experiment were tested. The skin test method and procedures are as follows. For the measurement of the mechanical skin, the subject should wash the whole area with the prepared cleaning agent first and then maintain the skin stability for about 30 minutes in a room of constant temperature and humidity condition (20 ~ 24 ℃, humidity 40 ~ 60% And adapted to the drill measurement environment. The test product application site was measured and conducted by the same researcher under the same condition every time.

Skin moisture content was measured by using a moisture meter (Corneometer) before and after use of the test product. For the measurement, first, the area of the test product non-wiping area and the area of the test product applying area were divided into 3 * 4 cm, respectively, and the moisture content of the skin before use was measured. Thereafter, the test product was uniformly applied to the divided portion of the amount of 2 mg / cm ² , and the skin moisture content was measured immediately after use of the product. The measured skin moisture content is AU (Arbitrary Unint), and the measured value is proportional to the degree of improvement in skin moisturizing power (FIG. 1). Fig. 1 shows changes in the skin moisture content according to the use of the nutritive cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2.

As a result of the experiment, it was confirmed that the nutrient cream prepared by the prescription of Example 1 and the essence prepared by the prescription of Example 2 both had a skin moisture content of 89.262% after using the product before using the product.

[ Experimental Example  2: Light skin moisture loss  Confirm]

As to Experimental Example 1, the amount of water-loss of the hard-skin surface was tested on 20 adult women aged 19 to 60 years who had no skin disease that would affect the results of the experiment. The skin test method and procedures are as follows. For the measurement of the mechanical skin, the subject should wash the whole area with the prepared cleaning agent first and then maintain the skin stability for about 30 minutes in a room of constant temperature and humidity condition (20 ~ 24 ℃, humidity 40 ~ 60% And adapted to the drill measurement environment. Test product application sites were measured and conducted by the same researchers under the same conditions each time.

The moisture content of the skin was measured using a Vaporometer before and after the use of the test product. For the measurement, the area of the test product non-embossed area and the area of the test product applied area were divided into 3 * 4 cm, respectively, and the amount of water loss of the epidermis before use was measured. Thereafter, the amount of the test product was uniformly applied to the area where the amount of 2 mg / cm ² was divided, and the amount of moisture loss of the hard skin was measured immediately after use of the product. The measured unit of water loss of skin epidermis is g / m ² h, and the measured value is proportional to the degree of skin epidermal water loss, which means that as the measured value decreases, the water loss of the epidermis is improved.

2 to 4), the nutrient cream prepared by the prescription of Example 1 showed an improvement rate of 23.046% after the product was used before the use of the two products, It was confirmed that the essence prepared by the prescription showed an improvement rate of 24.991%. Fig. 2 shows the changes in the amount of moisture loss of skin surface skin caused by use of the nutritional cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2. FIG. 3 is a graph showing the result of the amount of water-loss of the skin according to the use of the nutritional cream prepared according to the prescription composition of Example 1. FIG. FIG. 4 is a graph showing the result of the amount of water loss of the skin caused by the use of the essence prepared by the prescription composition of Example 2. FIG.

[ Experimental Example  3: skin primary stimulation evaluation]

The primary skin irritation evaluation was performed on 32 adult women aged 19 to 59 years without any skin disease that would affect the results of the experiment in Examples 1 to 2, A total of 30 subjects completed the test. In order to check the skin condition, the subjects were allowed to adapt to the measurement environment by taking the skin stability for about 30 minutes in the space of constant temperature and humidity condition (20 ~ 24 ℃, humidity 40 ~ 60%). The site of the test product was photographed, and the skin reaction was confirmed by two researchers under the same condition every time. The criteria were evaluated according to the criteria of the International Contact Dermatitis Research Group (ICDRG).

ICDRG skin irritation evaluation criteria sign Rating Criteria - 0 voice + One Some erythema with spots or scattered ++ 2 Uniform erythema of severity +++ 3 Erythematous erythema ++++ 4 Severe erythema with edema and vesicles

As a result of the application of the skin primer first stimulation human body test, the skin irritation index of the nutritional cream prepared by the prescription of Example 1 was 0.02, and the skin irritation index of the essence prepared by the prescription of Example 2 was 0.00, It was judged to be a formulation.

[ Experimental Example  4: skin adverse reaction evaluation]

For the above Examples 1 and 2, 30 patients who participated in the skin primary stimulation evaluation were further subjected to skin adverse reaction evaluation (FIG. 5). Fig. 5 shows evaluation of the skin adverse reaction according to the use of the nutritional cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2.

As a result of the experiment, it was confirmed that the skin adverse reaction was not observed in both the nutritional cream prepared by the prescription of Example 1 and the essence prepared by the prescription of Example 2.

[Experimental Example 5: Stability Test]

After preparing the nutrition cream and the essence according to the prescriptions of Examples 1 to 2, the change in the physical property stability was checked in the incubator set at 0 ° C, 5 ° C, 25 ° C and 45 ° C for 1 day to 4 weeks (Fig. 6). Fig. 6 shows the temperature stability (separation, discoloration and decoloration) of the nutritional cream prepared by the prescription composition of Example 1 and the essence prepared by the prescription composition of Example 2 according to temperature.

As a result, it was confirmed that the nutritional cream and essence prepared according to the prescriptions of Examples 1 to 2 of the present invention were excellent in temperature-dependent stability without separation, discoloration, and removal of the extract from one day to four weeks.

Taken together, the cosmetic composition of the present invention, which is prepared by applying the camellia seed oil aminopropanediol amide / ester to a formulation, is stable and remarkably improves the moisture content of the skin and the light-to-surface moisture loss, Can be usefully used.

Claims (4)

Camellia Japonica Seed Oil Aminopropanediol Amides / Esters) as an active ingredient,
The Camellia Japonica Seed Oil Aminopropanediol Amides / Esters,
The mixture is prepared by mixing Camellia japonica seed oil with 3-amino-1,2-propanediol and reacting with Novozym 435 enzyme. A cosmetic composition for skin moisturizing.
The method according to claim 1,
The camellia seed oil aminopropane diol amide /
And 0.10 to 80% by weight based on the whole cosmetic composition.
The method according to claim 1,
The above-
A cosmetic composition for moisturizing skin, characterized in that it is for preventing moisture loss of the hard skin.
The method according to claim 1,
In the cosmetic composition,
A cosmetic composition for moisturizing skin characterized by no skin irritation.

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