KR20190011836A - 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물 - Google Patents

돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물 Download PDF

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Publication number
KR20190011836A
KR20190011836A KR1020197002691A KR20197002691A KR20190011836A KR 20190011836 A KR20190011836 A KR 20190011836A KR 1020197002691 A KR1020197002691 A KR 1020197002691A KR 20197002691 A KR20197002691 A KR 20197002691A KR 20190011836 A KR20190011836 A KR 20190011836A
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South Korea
Prior art keywords
factor
binding protein
binding
meningitidis
composition
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Korean (ko)
Inventor
라첼 엑슬리
크리스토프 탕
수잔 엠. 리
Original Assignee
임페리얼 이노베이션스 리미티드
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Publication of KR20190011836A publication Critical patent/KR20190011836A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197002691A 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물 Ceased KR20190011836A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0819633.9 2008-10-25
GBGB0819633.9A GB0819633D0 (en) 2008-10-25 2008-10-25 Composition
PCT/GB2009/051439 WO2010046715A1 (en) 2008-10-25 2009-10-26 Vaccine compositions comprising a mutated factor h binding protein

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167035443A Division KR20170000390A (ko) 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물

Publications (1)

Publication Number Publication Date
KR20190011836A true KR20190011836A (ko) 2019-02-07

Family

ID=40133849

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020117011885A Ceased KR20110092282A (ko) 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물
KR1020167035443A Ceased KR20170000390A (ko) 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물
KR1020197002691A Ceased KR20190011836A (ko) 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물

Family Applications Before (2)

Application Number Title Priority Date Filing Date
KR1020117011885A Ceased KR20110092282A (ko) 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물
KR1020167035443A Ceased KR20170000390A (ko) 2008-10-25 2009-10-26 돌연변이 인자 h 결합 단백질을 포함하는 백신 조성물

Country Status (23)

Country Link
US (1) US20120052092A1 (https=)
EP (2) EP3501534B1 (https=)
JP (2) JP5676458B2 (https=)
KR (3) KR20110092282A (https=)
CN (2) CN105412920A (https=)
AU (1) AU2009306114B2 (https=)
BR (1) BRPI0919926A2 (https=)
CA (1) CA2741619A1 (https=)
CO (1) CO6382140A2 (https=)
DK (1) DK3501534T5 (https=)
ES (1) ES2970878T3 (https=)
FI (1) FI3501534T3 (https=)
GB (1) GB0819633D0 (https=)
HR (1) HRP20240226T1 (https=)
HU (1) HUE065348T2 (https=)
LT (1) LT3501534T (https=)
MX (1) MX2011004322A (https=)
NZ (2) NZ601538A (https=)
PL (1) PL3501534T3 (https=)
PT (1) PT3501534T (https=)
RU (1) RU2559528C2 (https=)
SI (1) SI3501534T1 (https=)
WO (1) WO2010046715A1 (https=)

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EP2261338A3 (en) 1998-05-01 2012-01-04 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
NZ515935A (en) 1999-05-19 2004-01-30 Chiron S Combination Neisserial compositions and vaccines for the prevention of infections due to Neisseria bacteria such as meningococcal meningitis
JP2004508801A (ja) 1999-10-29 2004-03-25 カイロン ソチエタ ア レスポンサビリタ リミタータ ナイセリア抗原性ペプチド
NZ521531A (en) 2000-02-28 2005-12-23 Chiron S Heterologous expression of neisserial proteins
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
HUE031886T2 (en) 2002-10-11 2017-08-28 Glaxosmithkline Biologicals Sa Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
CN102356089B (zh) 2008-02-21 2014-02-19 诺华股份有限公司 脑膜炎球菌fHBP多肽
AU2009223613B2 (en) 2008-03-10 2014-09-25 Children's Hospital & Research Center At Oakland Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use
EP2411048B1 (en) 2009-03-24 2020-05-06 GlaxoSmithKline Biologicals SA Adjuvanting meningococcal factor h binding protein
CA2759400A1 (en) 2009-04-30 2010-11-04 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) and methods of use
CA2779816A1 (en) * 2009-10-27 2011-05-05 Novartis Ag Modified meningococcal fhbp polypeptides
CA2792687A1 (en) * 2010-03-10 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition
TR201802933T4 (tr) 2010-03-30 2018-03-21 Childrens Hospital & Res Center At Oakland Özellikleri değiştirilmiş faktör h bağlama proteinleri (fhbp) ve bunların kullanım yöntemi.
AU2011268507B2 (en) 2010-06-25 2014-08-14 Novartis Ag Combinations of meningococcal factor H binding proteins
EP3299467B1 (en) 2012-02-02 2021-08-11 GlaxoSmithKline Biologicals SA Promoters for increased protein expression in meningococcus
AU2013276083B2 (en) 2012-06-14 2018-04-05 Institut Pasteur Vaccines for serogroup X meningococcus
WO2014016152A1 (en) 2012-07-27 2014-01-30 Institut National De La Sante Et De La Recherche Medicale Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
WO2014140562A1 (en) * 2013-03-14 2014-09-18 Isis Innovation Limited Immunogenic composition to neisseria
CN105431167A (zh) 2013-08-02 2016-03-23 奥克兰儿童医院及研究中心 非天然发生因子h结合蛋白(fhbp)及其使用方法
KR20160127104A (ko) 2014-02-28 2016-11-02 글락소스미스클라인 바이오로지칼즈 에스.에이. 변형된 수막구균 fhbp 폴리펩티드
KR102761870B1 (ko) 2014-07-23 2025-02-05 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 인자 h 결합 단백질 변이체 및 이의 사용 방법
CN107074939B (zh) * 2014-08-20 2021-09-07 桑昆血液供给基金会 H因子增强抗体及其用途
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
EP3897706A4 (en) 2018-12-21 2022-11-23 Griffith University COMPOSITIONS, METHODS AND USES FOR INDURING AN IMMUNE RESPONSE
EP3997108A4 (en) * 2019-07-08 2024-03-20 Crapaud Bio, Inc. METHODS OF PRODUCING AND USING LIPOOLIGOSACCHARIDE COMPOSITIONS AND VACCINES
TWI851771B (zh) 2019-07-17 2024-08-11 美商雙子治療子公司 因子h增強抗體及其用途
US12053516B2 (en) 2021-02-19 2024-08-06 Sanofi Pasteur Inc. Meningococcal B recombinant vaccine
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
US5476784A (en) * 1993-04-06 1995-12-19 Rice; Peter A. Gonococcal anti-idiotypic antibodies and methods and compositions using them
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
BRPI0409459A (pt) * 2003-04-16 2006-05-02 Wyeth Corp novas composições imunogênicas para a prevenção e tratamento de doença meningocócica
WO2006081259A2 (en) * 2005-01-27 2006-08-03 Children's Hospital & Research Center At Oakland Gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
GB0524066D0 (en) * 2005-11-25 2006-01-04 Chiron Srl 741 ii
US8039007B2 (en) * 2006-06-29 2011-10-18 J. Craig Venter Institute, Inc. Polypeptides from Neisseria meningitidis
CN102596240B (zh) * 2009-08-27 2015-02-04 诺华股份有限公司 包括脑膜炎球菌fHBP序列的杂交多肽
TR201802933T4 (tr) * 2010-03-30 2018-03-21 Childrens Hospital & Res Center At Oakland Özellikleri değiştirilmiş faktör h bağlama proteinleri (fhbp) ve bunların kullanım yöntemi.

Also Published As

Publication number Publication date
FI3501534T3 (fi) 2024-02-09
JP2012506411A (ja) 2012-03-15
CO6382140A2 (es) 2012-02-15
KR20170000390A (ko) 2017-01-02
EP2355845A1 (en) 2011-08-17
SI3501534T1 (sl) 2024-03-29
MX2011004322A (es) 2011-06-16
AU2009306114B2 (en) 2015-10-01
RU2011120706A (ru) 2012-11-27
CA2741619A1 (en) 2010-04-29
LT3501534T (lt) 2024-03-12
EP3501534A1 (en) 2019-06-26
GB0819633D0 (en) 2008-12-03
RU2559528C2 (ru) 2015-08-10
JP2015063558A (ja) 2015-04-09
AU2009306114A1 (en) 2010-04-29
CN105412920A (zh) 2016-03-23
PT3501534T (pt) 2024-02-07
EP3501534B1 (en) 2023-11-29
EP2355845B1 (en) 2018-12-05
PL3501534T3 (pl) 2024-04-02
JP5676458B2 (ja) 2015-02-25
HRP20240226T1 (hr) 2024-05-10
HUE065348T2 (hu) 2024-05-28
BRPI0919926A2 (pt) 2016-02-16
DK3501534T5 (da) 2024-09-02
DK3501534T3 (da) 2024-02-05
WO2010046715A1 (en) 2010-04-29
ES2970878T3 (es) 2024-05-31
KR20110092282A (ko) 2011-08-17
JP6076326B2 (ja) 2017-02-08
NZ592444A (en) 2012-11-30
NZ601538A (en) 2014-01-31
US20120052092A1 (en) 2012-03-01
CN102245202A (zh) 2011-11-16

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