KR20180122573A - Composition comprising extracts of banana, cherry, and walnut for anti-skin aging - Google Patents
Composition comprising extracts of banana, cherry, and walnut for anti-skin aging Download PDFInfo
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- KR20180122573A KR20180122573A KR1020180133106A KR20180133106A KR20180122573A KR 20180122573 A KR20180122573 A KR 20180122573A KR 1020180133106 A KR1020180133106 A KR 1020180133106A KR 20180133106 A KR20180133106 A KR 20180133106A KR 20180122573 A KR20180122573 A KR 20180122573A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
Abstract
Description
바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 방지 또는 개선하기 위한 조성물에 관한 것이다.To a composition for preventing or ameliorating skin damage, including extracts of bananas, cherries, and walnuts.
노화가 진행된 피부 조직에는 코르티솔 활성 효소의 발현이 증가되어 있다. 특히 여성의 폐경 후 노화된 피부 조직이나, 자외선에 의한 광노화가 진행된 피부 조직에서 코르티솔의 활성이 증가되어 있는 것으로 보고된 바 있다. 코르티솔은 스트레스 호르몬의 일종으로, 물리적인 손상이나 정신적인 스트레스가 가해질 때 체 내의 신장, 심장, 폐 및 피부 등의 기관에서 분비된다. 특히 피부에서 코르티솔은 콜라겐 합성과 관련이 있는데, 코르티솔의 장기간의 분비는 체내 콜라겐 대사에 영향을 미쳐 콜라겐 합성을 감소시키고, 결국 피부 위축(atrophodermia)등의 피부 손상의 원인이 될 수도 있다.The expression of cortisol activating enzyme is increased in aging skin tissue. In particular, it has been reported that the activity of cortisol is increased in aged skin tissues after menopause and in skin tissues where photoaging by ultraviolet light has progressed. Cortisol is a type of stress hormone that is secreted by organs such as the kidneys, heart, lungs and skin in the body when physical damage or mental stress is applied. In particular, cortisol in the skin is involved in the synthesis of collagen. The long-term secretion of cortisol affects collagen metabolism in the body, reducing collagen synthesis, and ultimately causing skin damage such as atrophodermia.
한편, 멜라토닌은 뇌의 송과체에서 생산되는 숙면을 유도하는 신경전달물질의 일종으로서, 햇빛을 쬐고 난 뒤 일정 시간 뒤에 생성되어 체내에서 여러 이로운 효과를 가진다. 특히 멜라토닌은 자유라디칼을 제거하고, 피부를 검게 만드는 멜라닌을 저해하여 피부 건강에 도움을 주며, 피부에 멜라토닌을 도포하면 자외선 손상에 의한 홍반 생성 완화 효과, 아토피성 피부염 완화 효과, 항산화 효과, 및 항노화 효과 등을 나타낸다고 보고되어 있다On the other hand, melatonin is a type of neurotransmitter that induces a sleeping surface produced in the pineal gland of the brain. It is produced after a certain period of time after sunlight and has various beneficial effects in the body. In particular, melatonin removes free radicals and inhibits melanin which makes skin darker, thereby contributing to skin health. When melatonin is applied to the skin, it is possible to prevent erythema formation, mitigate atopic dermatitis, Aging effects and the like have been reported
이에, 본 발명자들은 멜라토닌이 함유되어 있어 숙면에 도움이 되는 천연물로 알려져 있는 바나나, 체리 및 호두의 혼합 추출물을 피부 주름 개선 소재로 개발하고자 하였다. 아울러, 바나나, 체리 및 호두의 혼합 추출물은 진피 섬유아세포에서 억제된 MT-1, SIRT-1 및 카탈레이스의 활성을 회복시켜 피부 노화를 방지할 수 있음을 확인하여, 본 발명을 완성하게 되었다.Accordingly, the present inventors developed a mixed extract of bananas, cherries, and walnuts, which is known to be a natural substance that contains melatonin and helps in sleeping, as a skin wrinkle improving material. In addition, it was confirmed that the mixed extract of bananas, cherries, and walnuts can restore the activity of MT-1, SIRT-1 and catalase inhibited by dermal fibroblasts to prevent skin aging, thereby completing the present invention.
일 양상은 바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 방지 또는 개선하기 위한 화장료 조성물을 제공한다.One aspect provides a cosmetic composition for preventing or ameliorating skin damage comprising extracts of bananas, cherries, and walnuts.
다른 양상은 바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 개선하기 위한 건강기능식품용 조성물을 제공한다.Another aspect provides a composition for a health functional food for improving skin damage comprising an extract of bananas, cherries, and walnuts.
다른 양상은 바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 치료하기 위한 약학적 조성물을 제공한다.Another aspect provides a pharmaceutical composition for treating skin damage comprising extracts of bananas, cherries, and walnuts.
일 양상은 바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 개선하기 위한 화장료 조성물을 제공한다. 다른 양상은 바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 개선하기 위한 건강기능식품용 조성물을 제공한다. 다른 양상은 바나나, 체리, 및 호두의 추출물을 포함하는 피부 손상을 치료하기 위한 약학적 조성물을 제공한다.One aspect provides a cosmetic composition for improving skin damage comprising an extract of bananas, cherries, and walnuts. Another aspect provides a composition for a health functional food for improving skin damage comprising an extract of bananas, cherries, and walnuts. Another aspect provides a pharmaceutical composition for treating skin damage comprising extracts of bananas, cherries, and walnuts.
용어 "피부 손상"은 외부의 물리적 손상, 화학 물질, 세균, 곰팡이, 바이러스 등의 침투, 자외선에 대한 노출, 피부의 수분 손실, 노화 등에 의한 주름, 피부 색소 침착 및 스트레스 호르몬에 의한 피부 손상 등을 포함하는 피부 조직 또는 세포의 임상적 및 미용적 관점에서의 손상을 포함한다.The term "skin damage" refers to damage caused by external physical damage, penetration of chemicals, bacteria, fungi, viruses, exposure to ultraviolet rays, skin moisture loss, wrinkles caused by aging, skin pigmentation, Including damage from the clinical and cosmetic point of view of the skin tissue or cells involved.
바나나(Banana)는 파초과 바나나속에 속하는 식물을 총칭하는 것으로서, 무사 사피엔툼(Musa Sapientum) 또는 무사 파라디시아카 L.(Musa paradisiaca L.)의 학명을 갖는 식물 등을 포함한다. 비타민 A, B가 풍부하게 함유되어 있어 피부에 윤기와 탄력을 부여하여 노화를 예방하는데 탁월한 효과가 있으며, 트립토판이 함유되어 있어 체내 멜라토닌 합성에 도움을 줄 수 있다.Banana (Banana) is a generic term for plants belonging to the sub-parasitic bananas , and includes plants with the scientific name of Musa Sapientum or Musa paradisiaca L. It is rich in vitamins A and B, which gives skin radiance and elasticity to prevent aging, and contains tryptophan, which can help in the synthesis of melatonin in the body.
체리(Cherry)는 장미과 벚나무속에 속하는 식물을 의미하며, 프루누스 파우시플로라 번지(Prunus pauciflora Bunge), 프루누스 아비움(Prunus avium), 프루누스 세라수스 L.(Prunus cerasus L.) 또는 프루누스 에푸사 K.Schneider(Prunus effusa K. Schneider)의 학명을 갖는 식물 등을 포함한다. 붉은 빛을 나타내는 안토시아닌이 다량 함유되어 있어 항산화, 항염증, 항노화 효능을 가지고 있으며, 멜라토닌이 함유되어 있어 신체 피로를 감소시키고 건강을 유지하는데 도움을 줄 수 있다.Cherry means a plant belonging to the genus Rosaceae and is a plant belonging to the genus Prunus pauciflora Bunge, Prunus avium , Prunus cerasus L. or Prunus cerasus L., And plants having the scientific name of K. Schneider ( Prunus effusa K. Schneider). It contains antioxidant, anti-inflammation and anti-aging effect because it contains a lot of red anthocyanin. It contains melatonin, which can help reduce body fatigue and maintain health.
호두(walnut)는 가래나무과에 속하는 식물로서, 주글랜스 니그라(Juglans nigra L.), 주글랜스 레지아(Juglans regia), 또는 주글랜스 시넨시스(Juglans sinensis)의 학명을 갖는 식물 등을 포함한다. 리놀레인산과 비타민E를 함유하고 있어 각종 심혈관 질환을 예방함과 동시에 항산화 작용을 하여 피부 건강에 도움을 준다. 또한, 멜라토닌과 칼슘이 풍부하게 들어있어 불면증을 다스리는데 효과가 있다.The walnut is a plant belonging to the phasmatical family and includes plants with the names of Juglans nigra L., Juglans regia , or Juglans sinensis , and the like . It contains Linoleic Acid and Vitamin E to prevent various cardiovascular diseases and to help your skin by antioxidant action. It also contains melatonin and calcium, which is effective in controlling insomnia.
상기 바나나, 체리 및 호두의 추출물은 각각 그 수목의 지상부의 전체, 그 일부분, 또는 이들로부터 유래된 재료로부터 용매에 의하여 추출된 추출물일 수 있다. 상기 일부분은 수목의 줄기, 뿌리, 잎, 꽃, 꽃잎, 종실(씨앗), 과육, 열매 껍질 또는 열매일 수 있다. 추출에 사용된 상기 수목의 전체, 그 일부분, 또는 이들로부터 유래된 재료는 분쇄 또는 세절되거나 적당하게 건조된 것일 수 있다. The extracts of bananas, cherries and walnuts may be extracts extracted by solvent from whole, part of, or a material derived from the above ground part of the tree, respectively. The part may be a stem, root, leaf, flower, petal, seed, pulp, fruit skin or fruit of a tree. The whole, part of, or a material derived therefrom of the tree used for the extraction may be ground or chopped or suitably dried.
상기 추출물은 물, 아세톤, 알콜, 예를 들면, C1-C6 알콜, C3-C6의 다가 알콜 또는 이들의 혼합물을 용매로 이용하여 추출한 것일 수 있다. 상기 C1-C6 알콜은 메탄올, 에탄올, 프로판올, 이소프로판올, 1,3-프로판디올, 부탄올, 펜탄올, 또는 헥산올을 포함한다. 상기 용매는 예를 들면, 물과 알콜의 혼합물, 즉 알콜 수용액일 수 있다. 알콜 수용액의 알콜 농도는 1 내지 100(w/w)%, 예를 들면, 1 내지 99.5(w/w)%, 10 내지 100(w/w)%, 20 내지 100(w/w)%, 30 내지 100(w/w)%, 40 내지 100(w/w)%, 50 내지 100(w/w)%, 60 내지 100(w/w)%, 70 내지 100(w/w)%, 75 내지 100(w/w)%, 60 내지 90(w/w)%, 60 내지 80(w/w)%, 65 내지 75(w/w)%, 또는 70(w/w)%일 수 있다. 상기 알콜 수용액은 메탄올, 에탄올, 또는 부탄올 수용액일 수 있다.The extract may be extracted using water, acetone, alcohol, for example, C1-C6 alcohol, C3-C6 polyhydric alcohol, or a mixture thereof as a solvent. The C1-C6 alcohol includes methanol, ethanol, propanol, isopropanol, 1,3-propanediol, butanol, pentanol, or hexanol. The solvent may be, for example, a mixture of water and an alcohol, that is, an aqueous solution of an alcohol. The alcohol concentration of the alcohol aqueous solution may be 1 to 100 (w / w)%, for example 1 to 99.5 (w / w)%, 10 to 100 (w / (W / w)%, 40 to 100 (w / w)%, 50 to 100 (w / w)%, 60 to 100 (w / (W / w)%, 60 to 90 (w / w)%, 60 to 80 (w / w)%, 65 to 75 have. The aqueous alcohol solution may be methanol, ethanol, or an aqueous butanol solution.
상기 추출물은 가온 추출, 가압 추출, 초음파 추출, 열수 추출, 환류 냉각 추출, 아임계 추출, 또는 초임계 추출 등 당업계에서 통상적인 방법으로 추출된 것일 수 있다. 상기 추출은 4℃ 내지 70℃, 예를 들면, 4℃ 내지 50℃, 4℃ 내지 40℃, 4℃ 내지 30℃, 10℃ 내지 70℃, 15℃ 내지 70℃, 20℃ 내지 70℃, 4℃ 내지 50℃, 10℃ 내지 50℃, 4℃ 내지 40℃, 4℃ 내지 30℃, 10℃ 내지 40℃, 10℃ 내지 35℃, 또는 10℃ 내지 30℃, 또는 상온에서 수행하는 것일 수 있다. 상기 추출 시간은 선택된 온도 및 추출 방법에 따라 달라질 수 있는데 1시간 내지 3일, 1시간 내지 2일, 1시간 내지 1일, 5시간 내지 3일, 5시간 내지 2일, 5시간 내지 1일, 10시간 내지 3일, 15시간 내지 2일, 15시간 내지 36시간, 18시간 내지 30시간, 1일 내지 3일, 1일 내지 2일, 또는 24시간일 수 있다. 예를 들면, 각 열매의 분말을 추출 용매에 2내지 4시간 동안 침적하여 초음파 추출하거나, 용매를 가해 실온에서 24 내지 72시간 동안 침적하여 추출할 수 있다. 상기 추출은 1회 이상, 예를 들면 1회 내지 5회 반복될 수 있으며, 각 추출은 동일한 방법으로 수행되거나, 다른 방법으로 수행될 수 있다.The extract may be extracted by a conventional method in the art such as warm extraction, pressure extraction, ultrasonic extraction, hot water extraction, reflux cooling extraction, subcritical extraction, or supercritical extraction. The extraction may be carried out at a temperature of 4 ° C to 70 ° C, for example 4 ° C to 50 ° C, 4 ° C to 40 ° C, 4 ° C to 30 ° C, 10 ° C to 70 ° C, 15 ° C to 70 ° C, 10 C to 50 C, 10 C to 50 C, 4 C to 40 C, 4 C to 30 C, 10 C to 40 C, 10 C to 35 C, or 10 C to 30 C, . The extraction time may vary depending on the selected temperature and extraction method. The extraction time may be 1 to 3 days, 1 to 2 days, 1 hour to 1 day, 5 hours to 3 days, 5 hours to 2 days, 5 hours to 1 day, 10 hours to 3 days, 15 hours to 2 days, 15 hours to 36 hours, 18 hours to 30 hours, 1 day to 3 days, 1 day to 2 days, or 24 hours. For example, the powder of each fruit can be extracted by ultrasonic extraction by immersing in an extraction solvent for 2 to 4 hours, or by immersing in a solvent for 24 to 72 hours at room temperature. The extraction may be repeated one or more times, for example one to five times, and each extraction may be performed in the same way or may be carried out in other ways.
상기 추출은 식물체 잔여물 및 추출액을 여과 등의 알려진 방법에 의하여 분리하는 과정을 더 포함할 수 있다. 상기 추출은 또한 얻어진 추출액으로부터 감압 농축과 같은 알려진 방법에 의하여 용매를 제거하는 단계를 포함할 수 있다. 상기 추출은 또한 얻어진 추출물을 질소 건조 또는 동결 건조와 같은 건조에 의하여 건조 추출물을 제조하는 것을 포함할 수 있다. 상기 추출물은 농축액의 형태, 또는 건조된 이후 필요에 따라 DMSO 등 적절한 용매로 재용매화된 형태, 또는 동결 건조되어 분체화된 형태일 수 있다. The extraction may further include a step of separating the plant residue and the extract by a known method such as filtration. The extraction may also include removing the solvent from the resulting extract by known methods, such as concentration under reduced pressure. The extraction may also comprise preparing the dried extract by drying, such as nitrogen drying or lyophilization, of the resulting extract. The extract may be in the form of a concentrate or, after drying, if necessary, resolved in an appropriate solvent such as DMSO, or lyophilized and pulverized.
상기 조성물은 상기 추출물의 분획물을 더 포함할 수 있다. 분획물(fraction)은 상기 추출물이 그 일부의 성분으로 나누어진 물질, 즉 분획화(fractionation)되어진 물질을 의미하며, 당업계에 통상적으로 알려진 방법에 따라 분획화하여 얻을 수 있다.The composition may further comprise a fraction of the extract. The fraction means a substance in which the extract is divided into a part of its components, that is, a fractionated substance, and can be obtained by fractionation according to a method commonly known in the art.
상기 추출물은 바나나, 체리, 및 호두의 단독 추출물을 각각 추출한 후 혼합한 추출물일 수도 있고, 또는 바나나, 체리 및 호두의 파쇄 혼합물에 대한 추출물일 수 있다. 바나나, 체리 및 호두가 각각 단독 추출되는 경우 각각의 추출방법 및 추출조건은 같거나 다를 수 있다. 추출되는 바나나, 체리 및 호두, 또는 이들의 추출물의 중량비는 목적에 따라 적절하게 조절될 수 있다. 예를 들면, 바나나, 체리 및 호두 추출물은 그 원료 분말의 비율이 1~10 : 1~10 : 1~10 중량비일 수 있다. 또한 예를 들면, 바나나, 체리 및 호두 추출물은 그 추출물의 비율이 1~20 : 1~20 : 1~20 중량비, 또는 1~2 : 1~2 : 1~2 중량비일 수 있다.The extract may be an extract obtained by extracting individual extracts of bananas, cherries, and walnuts, respectively, or an extract for a crushed mixture of bananas, cherries and walnuts. When each of bananas, cherries, and walnuts is individually extracted, the extraction method and extraction conditions may be the same or different. The weight ratio of the extracted bananas, cherries and walnuts, or their extracts, can be suitably adjusted according to the purpose. For example, the ratio of the raw material powder to the banana, cherry, and walnut extract may be 1-10: 1 to 10: 1 to 10: 1. Also, for example, the extract of banana, cherry and walnut may have a ratio of the extract of 1 to 20: 1 to 20: 1 to 20, or 1 to 2: 1 to 2: 1 to 2.
상기 조성물은 조성물 총 중량에 대하여 0.001 중량% 내지 80 중량%, 예를 들면, 0.01 중량% 내지 60 중량%, 0.01 중량% 내지 40 중량%, 0.01 중량% 내지 30 중량%, 0.01 중량% 내지 20 중량%, 0.01 중량% 내지 10 중량%, 0.01 중량% 내지 5 중량%, 0.05 중량% 내지 60 중량%, 0.05 중량% 내지 40 중량%, 0.05 중량% 내지 30 중량%, 0.05 중량% 내지 20 중량%, 0.05 중량% 내지 10 중량%, 0.05 중량% 내지 5 중량%, 0.1 중량% 내지 60 중량%, 0.1 중량% 내지 40 중량%, 0.1 중량% 내지 30 중량%, 0.1 중량% 내지 20 중량%, 0.1 중량% 내지 10 중량%, 또는 0.1 중량% 내지 5 중량%의 바나나, 체리 및 호두 추출물을 포함할 수 있다. 상기 범위에서 0.01 중량% 미만일 경우 피부 개선 효과가 미약하게 될 우려가 있어 바람직하지 못하며, 60 중량%를 초과하는 것은 경제성 측면에서 바람직하지 못할 수 있다.The composition may be present in an amount of from 0.001% to 80%, such as from 0.01% to 60%, from 0.01% to 40%, from 0.01% to 30%, from 0.01% to 20% %, 0.01% to 10%, 0.01% to 5%, 0.05% to 60%, 0.05% to 40%, 0.05% to 30%, 0.05% to 20% From 0.05% to 10%, from 0.05% to 5%, from 0.1% to 60%, from 0.1% to 40%, from 0.1% to 30%, from 0.1% to 20% % To 10 wt%, or 0.1 wt% to 5 wt% of banana, cherry, and walnut extract. If it is less than 0.01% by weight in the above range, the effect of improving the skin tends to be insignificant, and it is not preferable that it is more than 60% by weight from the viewpoint of economy.
상기 조성물은 상기 추출물을 유효한 양, 또는 유효 성분으로서 포함할 수 있다. 상기 유효한 양은 개체에 따라 적절하게 선택할 수 있다. 질환 내지 상태의 중증도, 개체의 연령, 체중, 건강, 성별, 개체의 추출물에 대한 민감도, 투여 시간, 투여 경로 및 배출 비율, 투여 기간, 상기 조성물과 배합 또는 동시 사용되는 다른 조성물을 포함한 요소 및 기타 생리 내지 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다.The composition may contain the extract in an effective amount or as an active ingredient. The effective amount may be appropriately selected depending on the individual. The severity of the disease or condition, the age, weight, health, sex, sensitivity of the individual to the extract, time of administration, route and rate of excretion, duration of administration, factors including other compositions combined or co- May be determined according to factors well known in the art, physiology or medical field.
상기 조성물이 화장료 조성물인 경우, 추출물은 화장수(스킨로션), 스킨소프너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스쳐 로션, 영양 로션, 마사지크림, 영양 크림, 모이스쳐 크림, 핸드크림, 파운데이션, 에센스, 영양 에센스, 팩, 비누, 클렌징폼, 클렌징로션, 클렌징크림, 바디로션, 바디클렌저, 현탁액, 겔, 분말, 페이스트, 마스크팩 또는 시트 또는 에어로졸 조성물을 포함하는 제형으로 제조될 수 있다. 이러한 제형의 조성물은 당해 분야에서 통상적인 방법에 따라 제조될 수 있다. 상기 화장료 조성물은 보존제, 안정화제, 계면활성제, 용해제, 보습제, 에몰리언트제, 자외선 흡수제, 방부제, 살균제, 산화 방지제, pH 조정제, 유기 및 무기 안료, 향료, 냉감제 또는 제한제 등을 더 포함할 수 있다. 상기 보습제 등의 추가 성분의 배합량은 본 발명의 목적 및 효과를 손상시키지 않는 범위 내에서 당업자가 용이하게 선정 가능하며, 그 배합량은 조성물 전체 중량을 기준으로 0.001 내지 5 중량%, 구체적으로 0.01 내지 3 중량%일 수 있다.When the composition is a cosmetic composition, the extract can be used as a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, , A nutritional essence, a pack, a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion, a body cleanser, a suspension, a gel, a powder, a paste, a mask pack or a sheet or an aerosol composition. Compositions of such formulations may be prepared according to methods conventional in the art. The cosmetic composition may further contain preservatives, stabilizers, surfactants, solubilizers, moisturizers, emollients, ultraviolet absorbers, preservatives, bactericides, antioxidants, pH regulators, organic and inorganic pigments, fragrances, have. The amount of the additional component such as the above-mentioned moisturizing agent and the like can be easily selected by those skilled in the art within a range not to impair the purpose and effect of the present invention. The amount of the additional component is 0.001 to 5% by weight, % ≪ / RTI >
상기 추출물은 피부노화 방지 또는 개선용 피부 외용제 조성물일 수 있다. 상기 피부 외용제 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어 유액, 크림, 화장수, 팩, 파운데이션, 로션, 미용액, 모발화장료 등을 들 수 있다. 구체적으로는, 스킨로션, 스킨소프너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스처로션, 영양로션, 맛사지크림, 영양크림, 모이스처크림, 핸드크림, 파운데이션, 에센스, 영양에센스, 팩, 비누, 클렌징 폼, 클렌징로션, 클렌징크림, 바디로션 및 바디클렌저의 제형을 포함한다.The extract may be an external preparation for skin to prevent or improve skin aging. The composition for external application for skin may be prepared in any formulations conventionally produced in the art, and examples thereof include emulsion, cream, lotion, pack, foundation, lotion, essence and hair cosmetic. Specifically, the present invention relates to a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, a nutritive cream, a moisturizing cream, a hand cream, a foundation, Foams, cleansing lotions, cleansing creams, body lotions and body cleansers.
상기 조성물이 건강기능식품용 조성물인 경우, 당해 기술분야에 공지되어 있는 통상적인 건강기능식품의 제형으로 제제화될 수 있다. 상기 건강기능식품용 조성물은 예를 들어 산제, 과립제, 정제, 환제, 캅셀제, 현탁액, 유제, 시럽제, 침제, 액제, 엑스제 등의 일반적인 제형으로 제조될 수도 있고, 육류, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 젤리, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등의 임의의 건강식품 형태로 제조될 수도 있다. 상기 건강식품의 제제화를 위해 식품학적으로 허용 가능한 담체 또는 첨가제를 사용할 수 있으며, 제조하고자 하는 제형의 제조에 당해 기술분야에서 사용 가능한 것으로 공지되어 있는 임의의 담체 또는 첨가제가 이용될 수 있다. 상기 첨가제로서 각종 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 이외에도 천연 과일쥬스, 과일쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 첨가제 성분은 독립적으로 또는 조합하여 사용할 수 있으며, 첨가제의 비율은 조성물 전체 중량을 기준으로 0.001 내지 5 중량%, 구체적으로 0.01 내지 3 중량%일 수 있다.When the composition is a composition for a health functional food, it can be formulated into a typical health functional food formulation known in the art. The composition for health functional foods may be prepared by conventional formulations such as powders, granules, tablets, pills, capsules, suspensions, emulsions, syrups, And may be manufactured in the form of any health food such as candy, snacks, confectionery, pizza, ramen, other noodles, dairy products including gums, jellies, ice cream, various soups, drinks, tea, drinks, alcoholic beverages and vitamin complexes . A pharmaceutically acceptable carrier or additive may be used for the formulation of the health food, and any carrier or additive known to be usable in the art for the preparation of the formulation to be prepared may be used. As the above-mentioned additives, there can be used various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, Carbonating agents, and the like. In addition, it may contain natural fruit juice, fruit juice beverage and flesh for the production of vegetable beverages. These additive components may be used independently or in combination, and the proportion of the additive may be 0.001 to 5 wt%, specifically 0.01 to 3 wt%, based on the total weight of the composition.
상기 건강기능식품용 조성물 중의 상기 추출물의 함량은 사용 목적(예방 또는 개선)에 따라 적합하게 결정될 수 있다. 일반적으로, 전체 식품 중량의 0.01 내지 15 중량%로 포함할 수 있으며, 음료로서 제조될 경우 100 mL를 기준으로 0.02 내지 10 g, 바람직하게는 0.3 내지 1 g의 비율로 함유할 수 있다. The content of the extract in the health functional food composition may be suitably determined according to the intended use (prevention or improvement). Generally, it may contain 0.01 to 15% by weight of the total food, and when it is prepared as a beverage, it may contain 0.02 to 10 g, preferably 0.3 to 1 g, based on 100 mL.
상기 음료는 상기 추출물 이외의 다른 성분을 더 포함할 수 있으며, 통상적으로 음료에 사용되는 다양한 향미제 또는 천연 탄수화물 등을 더 함유할 수 있다. 상기 천연 탄수화물로는 단당류(예: 포도당, 과당 등), 이당류(예: 말토즈, 수크로즈 등), 다당류(예: 덱스트린, 시클로덱스트린 등)와 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이 함유될 수 있다. 또한, 향미제로서 천연 향미제(예: 타우마틴, 스테비아 추출물 등) 및 합성 향미제(예: 사카린, 아스파탐 등)를 함유할 수 있다. 상기 천연 탄수화물의 비율은 음료 100 mL 당 일반적으로 약 1 내지 20g, 바람직하게는 약 5 내지 12g으로 함유될 수 있다.The beverage may further contain ingredients other than the above extract, and may further contain various flavors or natural carbohydrates commonly used in beverages. Examples of the natural carbohydrate include conventional sugars such as monosaccharides such as glucose and fructose; disaccharides such as maltose and sucrose; polysaccharides such as dextrin and cyclodextrin; and sugars such as xylitol, sorbitol, erythritol, Of sugar alcohols may be contained. In addition, as a flavoring agent, a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.) may be contained. The ratio of the natural carbohydrate may be generally about 1 to 20 g, preferably about 5 to 12 g per 100 mL of beverage.
상기 조성물이 약학적 조성물일 수 있다. 상기 조성물은 약제학적으로 허용가능한 희석제 또는 담체를 포함할 수 있다. 상기 희석제는 유당, 옥수수 전분, 대두유, 미정질 셀룰로오스, 또는 만니톨, 활택제로는 스테아린산 마그네슘, 탈크, 또는 그 조합일 수 있다. 상기 담체는 부형제, 붕해제, 결합제, 활택제, 또는 그 조합일 수 있다. 상기 부형제는 미정질 셀룰로오스, 유당, 저치환도 히드록시셀룰로오스, 또는 그 조합일 수 있다. 상기 붕해제는 카르복시메틸셀룰로오스 칼슘, 전분 글리콜산 나트륨, 무수인산일수소 칼슘, 또는 그 조합일 수 있다. 상기 결합제는 폴리비닐피롤리돈, 저치환도 히드록시프로필셀룰로오스, 히드록시프로필셀룰로오스, 또는 그 조합일 수 있다. 상기 활택제는 스테아린산 마그네슘, 이산화규소, 탈크, 또는 그 조합일 수 있다.The composition may be a pharmaceutical composition. The composition may comprise a pharmaceutically acceptable diluent or carrier. The diluent may be lactose, corn starch, soybean oil, microcrystalline cellulose, or mannitol, the lubricant may be magnesium stearate, talc, or combinations thereof. The carrier may be an excipient, a disintegrant, a binder, a lubricant, or a combination thereof. The excipient may be microcrystalline cellulose, lactose, low substituted hydroxy cellulose, or combinations thereof. The disintegrant may be carboxymethylcellulose calcium, starch glycolate sodium, calcium monohydrogen phosphate anhydrate, or a combination thereof. The binder may be polyvinylpyrrolidone, low-substituted hydroxypropylcellulose, hydroxypropylcellulose, or combinations thereof. The lubricant may be magnesium stearate, silicon dioxide, talc, or a combination thereof.
본 발명자들은 노화 방지 또는 개선을 위한 숙면 효과가 있다고 알려진 천연물을 비교 선별하던 중, 상기 바나나, 체리 및 호두의 혼합 추출물이 피부 노화와 관련된 항산화 인자인 카탈레이스(catalase)와 노화 관련 인자 SIRT-1, 멜라토닌 수용체인 MT-1을 효과적으로 회복시킴을 확인하고 본 발명을 완성하게 되었다.The inventors of the present invention have found that when extracting natural products known to have a sleeping effect for preventing or improving aging, the mixed extract of bananas, cherries, and walnuts is used as an antioxidative factor related to skin aging, catalase and aging-related factor SIRT-1 , And MT-1, which is a melatonin receptor, and thus completed the present invention.
또한, 바나나, 체리 및 호두의 혼합 추출물의 경우, 단독 추출물에 비해 스트레스 호르몬에 의해 감소된 MT-1, SIRT-1, 카탈레이스의 회복 효과가 현저히 증가하는 것을 확인할 수 있었다. 이에 비추어보면, 바나나, 체리 및 호두의 혼합 추출물은 바나나, 체리 및 호두 단독 추출물에 비해 단순한 조합 이상의 시너지 효과를 나타내고, 이러한 시너지 효과로 피부 노화 또는 주름을 예방 또는 개선할 수 있음을 알 수 있다.In addition, in the case of the mixed extract of banana, cherry and walnut, the recovery effect of MT-1, SIRT-1 and catalase reduced by the stress hormone was remarkably increased compared with the single extract. In view of this, it can be seen that the mixed extract of bananas, cherries and walnuts shows a synergistic effect more than a simple combination in comparison with the extracts of bananas, cherries and walnuts alone, and that synergy effect can prevent or improve skin aging or wrinkles.
바나나, 체리, 및 호두의 추출물을 포함하는 조성물은 MT-1, SIRT-1 및 카탈레이스의 발현을 회복시켜 피부 손상을 방지 또는 개선하는데 유용하다.Compositions comprising extracts of bananas, cherries, and walnuts are useful for restoring the expression of MT-1, SIRT-1 and catalase to prevent or ameliorate skin damage.
도 1은 바나나 추출물, 체리 추출물, 호두 추출물 및 이들의 혼합 추출물의 MT-1의 발현 회복 효과를 나타낸다.
도 2는 바나나 추출물, 체리 추출물, 호두 추출물 및 이들의 혼합 추출물의 SIRT-1의 발현 회복 효과를 나타낸다.
도 3은 바나나 추출물, 체리 추출물, 호두 추출물 및 이들의 혼합 추출물의 카탈레이스의 발현 회복 효과를 나타낸다.1 shows the effect of restoring the expression of MT-1 in banana extract, cherry extract, walnut extract and mixed extract thereof.
FIG. 2 shows the effect of restoring the expression of SIRT-1 in banana extract, cherry extract, walnut extract and mixed extract thereof.
FIG. 3 shows the effect of restoring expression of catalase in banana extract, cherry extract, walnut extract and mixed extract thereof.
이하 본 발명을 실시예를 통하여 보다 상세하게 설명한다. 그러나, 이들 실시예는 본 발명을 예시적으로 설명하기 위한 것으로 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.
비교예 1: 바나나 추출물의 제조Comparative Example 1: Preparation of banana extract
바나나(Musa Sapientum) 열매에 대한 원료 분말을 100g 취하여 각각 별개의 용기에 넣고, 추출용매로서 70 중량% 에탄올 수용액 1L에 침적하였다. 이후 24시간 동안 실온에 방치하여 추출액을 얻었다. 얻은 추출액을 여과지를 이용하여 여과를 한 후, 여액을 회전식 증발 건조기로 감압 농축하여 최종 바나나 추출물을 얻었다. 최종 추출물은 DMSO(Dimethylsulfoxide)에 1 중량%의 농도로 용해시켜 이하의 실험예에 사용하였다.100 g of the raw material powder for the fruit of bananas ( Musa Sapientum ) was placed in a separate container and immersed in 1 L of a 70% by weight aqueous ethanol solution as an extraction solvent. After that, the mixture was allowed to stand at room temperature for 24 hours to obtain an extract. The obtained extract was filtered using a filter paper, and the filtrate was concentrated under reduced pressure using a rotary evaporator to obtain a final banana extract. The final extract was dissolved in DMSO (dimethyl sulfoxide) at a concentration of 1% by weight and used in the following Experimental Examples.
비교예 2: 체리 추출물의 제조Comparative Example 2: Preparation of cherry extract
체리(Prunus pauciflora Bunge) 열매에 대한 원료 분말을 100g 취하여 각각 별개의 용기에 넣고, 추출용매로서 70 중량% 에탄올 수용액 1L에 침적하였다. 이후 24시간 동안 실온에 방치하여 추출액을 얻었다. 얻은 추출액을 여과지를 이용하여 여과를 한 후, 여액을 회전식 증발 건조기로 감압 농축하여 최종 체리 추출물을 얻었다. 최종 추출물은 DMSO에 1 중량%의 농도로 용해시켜 이하의 실험예에 사용하였다.100 g of the raw material powder of cherry ( Prunus pauciflora Bunge ) was put into separate containers and immersed in 1 L of a 70 wt% aqueous ethanol solution as an extraction solvent. After that, the mixture was allowed to stand at room temperature for 24 hours to obtain an extract. The obtained extract was filtered using a filter paper, and the filtrate was concentrated under reduced pressure using a rotary evaporator to obtain a final cherry extract. The final extract was dissolved in DMSO at a concentration of 1% by weight and used in the following experimental examples.
비교예 3: 호두 추출물의 제조Comparative Example 3: Preparation of walnut extract
호두(Juglans nigra L.) 씨앗에 대한 원료 분말을 100g 취하여 각각 별개의 용기에 넣고, 추출용매로서 70 중량% 에탄올 수용액 1L에 침적하였다. 이후 24시간 동안 실온에 방치하여 추출액을 얻었다. 얻어진 추출액을 여과지를 이용하여 여과를 한 다음, 여액을 회전식 증발 건조기로 감압 농축하여 최종 호두 추출물을 얻었다. 최종 추출물은 DMSO에 1 중량%의 농도로 용해시켜 이하의 실험예에 사용하였다.100 g of raw material powder for seeds of walnut ( Juglans nigra L.) was put into separate containers and immersed in 1 L of a 70% by weight aqueous ethanol solution as an extraction solvent. After that, the mixture was allowed to stand at room temperature for 24 hours to obtain an extract. The obtained extract was filtered using a filter paper, and the filtrate was concentrated under reduced pressure using a rotary evaporator to obtain a final walnut extract. The final extract was dissolved in DMSO at a concentration of 1% by weight and used in the following experimental examples.
실시예 1: 바나나, 체리 및 호두 혼합 추출물의 제조Example 1: Preparation of a Banana, Cherry and Walnut Mixture Extract
상기 비교예 1-3에서 얻은 바나나, 체리, 및 호두 각각의 추출물을 바나나:체리:호두(중량비)=1:1:1로 혼합하여 이하의 실험예에 사용하였다. 혼합 추출물은 DMSO에 용해시켰다 (바나나, 체리, 호두 추출물 각각 0.33 중량%, 혼합 추출물 전체 1 중량%, 10 μg/mL).The extracts of each of the bananas, cherries, and walnuts obtained in Comparative Example 1-3 were mixed in a ratio of 1: 1: 1 in the ratio of banana: cherry: walnut (weight ratio). Mixed extracts were dissolved in DMSO (0.33% by weight of bananas, cherry and walnut extracts, 1% by weight of mixed extracts, 10 μg / mL).
실험예 1: MT-1, SIRT-1, 카탈레이스(catalase) 회복 효능 실험EXPERIMENTAL EXAMPLE 1: MT-1, SIRT-1, Catalase Recovery Efficiency Test
상기 비교예 1-3 및 실시예 1의 추출물들의 MT-1, SIRT-1, 및 카탈레이스 회복 효과를 확인하였다. 이를 위해 덱사메타손을 처리한 신경모세포 배양액에 사람 섬유아세포를 4x105/well의 밀도로 접종한 후 37℃, 5% CO2 배양기에서 24시간 배양하였다. MT-1, SIRT-1, and catalase recovery effects of the extracts of Comparative Examples 1-3 and Example 1 were confirmed. To this end, human fibroblasts were inoculated into dexamethasone-treated neuroblast cultures at a density of 4 × 10 5 / well and cultured in a 5% CO 2 incubator at 37 ° C. for 24 hours.
구체적으로, 신경모세포에 1 μM 덱사메타손을 처리한 후 24시간 배양하여 배양액을 획득하였다. 상기 배양액에 사람 진피 섬유아세포를 4x105/well의 밀도로 접종하였다. 이후 상기 비교예 1-3과 실시예 1을 각각 1 mL(10 μg/mL) 첨가하여 37℃, 5% CO2 배양기에서 24시간 동안 배양하였다. 100 μL의 용해 버퍼를 첨가하여 단백질을 추출하였다. 추출된 단백질에 브래드포드 에세이(Bradford assay)를 수행하고 595 ㎚ 파장에서 흡광도를 측정하여 단백질을 정량하였다. 또한 SDS-PAGE를 수행하고 PVDF(Polyvinylidene fluoride, Bio-rad, 미국)에 단백질 밴드를 전달하여 ECL(Enhanced chemiluminescence, ThermoScientific, 미국) 용액으로 단백질 발현량을 확인하였다.Specifically, neuroblasts were treated with 1 μM dexamethasone and cultured for 24 hours to obtain a culture solution. Human dermal fibroblasts were inoculated into the culture at a density of 4 x 10 < 5 > / well. Then, 1 mL (10 μg / mL) of each of Comparative Example 1-3 and Example 1 was added and cultured in a 5% CO 2 incubator at 37 ° C. for 24 hours. 100 μL of lysis buffer was added to extract proteins. The Bradford assay was performed on the extracted proteins and the protein was quantified by measuring the absorbance at 595 nm wavelength. In addition, SDS-PAGE was performed and the protein band was transferred to PVDF (Polyvinylidene fluoride, Bio-Rad, USA), and the protein expression level was confirmed by ECL (Enhanced chemiluminescence, ThermoScientific, USA) solution.
그 결과, 도 1 내지 3에 나타낸 바와 같이 실시예 1의 추출물을 처리하였을 때 가장 높은 MT-1, SIRT-1, 및 카탈레이스 회복 효과를 보였다. 또한, 아래 표 1과 같이 각 단백질이 측정되었다.As a result, as shown in Figs. 1 to 3, when the extract of Example 1 was treated, it showed the highest MT-1, SIRT-1, and catalase recovery effect. In addition, each protein was measured as shown in Table 1 below.
보정값beta -actin
Correction value
상기 결과와 같이, 바나나, 체리 또는 호두 추출물 각각이 세포 배양물에 첨가되는 경우보다 혼합 추출물로서 첨가되는 경우 서로 상승적 효과를 나타내는 것을 확인할 수 있었다.As shown in the above results, it was confirmed that each of the banana, cherry or walnut extracts exhibited a synergistic effect when added as a mixed extract, rather than when added to a cell culture.
실험예 2: 바나나, 체리 및 호두 추출물의 혼합 비율에 따른 MT-1, SIRT-1, 카탈레이스(catalase) 회복 효능 실험Experimental Example 2: Experiments on the recovery effect of MT-1, SIRT-1 and catalase according to the mixing ratio of the banana, cherry and walnut extracts
상기 비교예 1-3에서 얻은 바나나, 체리, 및 호두 각각의 추출물을 바나나:체리:호두(중량비)=1:1:1, 2:1:1, 1:2:1 또는 1:1:2로 혼합하여 이하의 실험예에 사용하였다. 혼합 추출물은 DMSO에 용해시켰다 (혼합 추출물 전체 1 중량%, 10 μg/mL). 이후 실험예 1과 같은 방법으로 단백질의 양을 정량하였다.The extracts of each of the bananas, cherries and walnuts obtained in the above Comparative Example 1-3 were mixed in a ratio of 1: 1: 1, 2: 1: 1, 1: 2: 1 or 1: 1: 2 And used in the following experimental examples. Mixed extracts were dissolved in DMSO (1% total mixed extract, 10 μg / mL). Then, the amount of protein was quantified by the same method as Experimental Example 1.
그 결과는 도 4 및 아래 표 2와 같다.The results are shown in FIG. 4 and Table 2 below.
보정값 Beta-actin
Correction value
1:1:1 Example
1: 1: 1
2:1:1 Example
2: 1: 1
1:2:1 Example
1: 2: 1
1:1:2 Example
1: 1: 2
상기 결과와 같이, 1:1:1 비율보다 1~2:1~2:1~2 비율로 혼합되는 경우 더 우수한 회복능을 나타냈으며, 특히 바나나, 체리 및 호두 추출물이 1:2:1 비율로 혼합되는 경우 MT-1 및 카탈레이스 회복에 의한 항노화 효과가 가장 큰 것을 확인하였다.1 to 2: 1 to 2: 1 to 2 as compared with the ratio of 1: 1: 1 as shown in the above results. In particular, when the bananas, cherry and walnut extracts were mixed in a ratio of 1: 2: 1 , It was confirmed that the anti-aging effect due to MT-1 and catalase recovery was greatest.
제형예 1: 토너제의 제조Formulation Example 1: Preparation of Toner
상기 실시예 1의 추출물을 함유하는 토너제를 하기의 표 3에 나타낸 조성 성분 및 조성비에 따라 통상적인 방법으로 제조하였다.The toner preparation containing the extract of Example 1 was prepared in a conventional manner according to the compositional components and composition ratios shown in Table 3 below.
제형예 2: 로션제의 제조Formulation Example 2: Preparation of lotion agent
상기 실시예 1에서 얻은 추출물을 함유하는 로션제를 하기의 표 4에 나타낸 조성 성분 및 조성비에 따라 통상적인 방법으로 제조하였다.Lotion preparations containing the extracts obtained in Example 1 were prepared according to the conventional methods according to the composition components and composition ratios shown in Table 4 below.
제형예 3: 크림제의 제조Formulation Example 3: Preparation of cream agent
상기 실시예 1에서 얻은 추출물을 함유하는 크림제를 하기의 표 5에 나타낸 조성 성분 및 조성비에 따라 통상적인 방법으로 제조하였다.The creams containing the extracts obtained in Example 1 were prepared according to the conventional methods according to the compositional components and composition ratios shown in Table 5 below.
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