KR20180110357A - Cosmetic composition for preventing oxidative stress comprising nephrite water and nephrite powder - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving oxidative stress having nephrite water and nephrite powder as an active ingredient. The nephrite powder and nephrite water used in the cosmetic composition of the present invention did not contain harmful heavy metals in a human body, but those obtained through a process of removing harmful microorganisms were used. The nephrite powder and nephrite water are rich in various minerals, so it is possible to supply enough useful minerals necessary for skin. The nephrite powder and nephrite water are excellent in elimination ability of active oxygen and nitrite, and thus can be usefully used in production of functional cosmetics capable of reducing and improving the oxidative stress of the skin.

Description

[0001] The present invention relates to a cosmetic composition for preventing oxidative stress comprising nephrite water and nephrite powder,

The present invention relates to a cosmetic composition having an oxidative stress inhibitory activity, which comprises corn oil and nephrite powder as an active ingredient.

Oxidation refers to the loss of electrons by an atom, a molecule, or an ion, or a substance that bonds with oxygen or loses hydrogen. Burning or rusting, alcohol turns into aldehyde, oil sore, and apples are browning are all redox reactions. In these phenomena, it can appear even if it is kept in the air only, and the cause of the oxidation reaction is just oxygen.

On the other hand, such an oxidation reaction occurs in the skin, for example, by active oxygen having a strong oxidizing power. Active oxygen, also called noxious oxygen, is oxygen in an unstable state completely different from the oxygen we breathe. Oxygen is overproduced due to environmental pollution, chemicals, ultraviolet rays, blood circulation disorder, and stress. This overproduced free radical oxidizes in the human body. This will damage the cell membrane, DNA, and all other cell structures, and the cells will either lose function or become altered depending on the extent of the damage. Along with this, various amino acids in the body are oxidized, resulting in a decrease in protein function. And it damages the nucleic acid, it deforms the nucleic acid base, it cuts the glass, the bond, and the oxidative decomposition of the sugar, and it becomes the cause of the mutation and the cancer. In addition, the physiological function is degraded, causing various diseases and aging.

Therefore, studies are under way to protect the human body from oxidative stress like active oxygen, and many antioxidants have been developed as a result of the research. Antioxidants include vitamin E, vitamin C, uric acid, bilirubin, glutathione and carotene.

On the other hand, antioxidants are often taken as food or supplements, but ingestion is not easy to reach the skin. Skin is wrapped around the outermost part of the human body, and it is always in contact with harmful factors such as external environment and ultraviolet rays, but it is a peripheral organ which is not directly connected with life. Therefore, if vitamin or antioxidant is insufficient in body, easy. In other words, from the viewpoint of the human body, it first supplies necessary components to the organs important for survival, such as the five small pieces, and then delivers the remaining ingredients to the skin. Therefore, it is necessary to develop an antioxidant composition capable of inhibiting oxidative stress on the skin in the form of cosmetics.

Accordingly, the present inventors have completed the present invention by producing a novel cosmetic composition having excellent oxidative stress inhibitory effect including nephrite powder and corn oil.

Korean Patent Publication No. 10-2011-0023437

Accordingly, an object of the present invention is to provide a cosmetic composition for improving oxidative stress comprising a nephrite powder and a corn starch as an active ingredient.

Another object of the present invention is to provide a cosmetic method having an effect of reducing the oxidative stress of the skin by applying the cosmetic composition of the present invention to human skin.

In order to achieve the object of the present invention as described above, the present invention provides a cosmetic composition for improving oxidative stress comprising nephrite powder and corn starch as an effective ingredient.

In one embodiment of the present invention, the nephrite powder may be obtained by pulverizing pomegranate ore and sterilizing by heating at 200 to 250 ° C for 2 to 3 hours.

In one embodiment of the present invention, the corn starch may be sterilized with steam at a temperature of 120 to 125 ° C. and a pressure of 2 to 3 atm for 20 to 30 minutes.

In one embodiment of the present invention, the composition may be a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, a nutritive cream, And may be formulated into a product selected from the group consisting of a pack, a soap, a shampoo, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion, a body cleanser, a latex, a lipstick, a makeup base, a foundation, a press powder and a loose powder have.

The present invention also provides a makeup method characterized in that the cosmetic composition of the present invention is applied to human skin to reduce the oxidative stress of the skin.

The present invention relates to a cosmetic composition for improving oxidative stress comprising nephrite powder and corn oil as an active ingredient, wherein the nephrite powder and the corn starch used in the cosmetic composition of the present invention contain no harmful heavy metals, And has various minerals abundantly contained therein. Therefore, it has an effect of supplying enough useful minerals required for the skin, and is excellent in the elimination ability of active oxygen and nitrite, thereby reducing the oxidative stress of the skin And can be usefully used for the production of functional cosmetics that can be improved.

FIG. 1 shows the result of superoxide scavenging analysis of the nephrite powder of the present invention.
FIG. 2 shows the nitrite scavenging ability analysis of the nephrite powder of the present invention.

The present invention is characterized by providing a cosmetic composition for improving oxidative stress comprising an ophthalmic solution and a nephrite powder as an active ingredient.

Octopus is a kind of water that comes out of Dong-bo-bo, which means spring water from a jade in a valley. According to Dongyobogam, the nature of this water is gentle, tasteful, clean, poisonous, and if there is a jade in the mountains, the grass and trees are also lustrous. When a person eats for a long time, the five-pods become rich, the waste in the body escapes, and the hair is not whitened. It is said that Chinese people have always been jade prisoners and they carry them on their bodies. This is because they have direct effects on the human body, stabilizing the nerves, and enhancing the functions of the five muscles. On the other hand, the efficacy of such corn oil is gradually being clarified by modern science. Chuncheon pomegranate has positive ions such as Ca ++, Mg ++, Na +, K +, and anions such as HCO- and Cl-SO3- And dissolved in water. Particularly, Ca ++ and Mg ++ ions are appropriately present in the corn oil, so that the ion action is activated and the anion activates the biorhythm activation, thereby expanding blood vessels to lower blood pressure to normal blood pressure, There is an effect by an anion such as restoring fatigue.

The pomegranate powder, which is another major component contained in the composition of the present invention, is obtained by pulverizing pomegranate ore. The pomegranate is a monoclinic fumed stone optical material of Inosilicates, And purgatory. Their quality is determined by their fine structure, that is, the degree of taxation in which biotite-spermatozoa sperm are squeezed and made into fibers. The thinner the fibers, the better quality is known.

In particular, nephrite is mainly composed of three minerals beneficial to human body, calcium, iron and magnesium, unlike sodium and aluminum composition of jadeite, and is used for the treatment of hypertension, diabetic cardiovascular disease, Has been reported recently as having a great influence on the healing of the gem, which was mentioned in the magical power of jewels, written by Heddibulousius of Germany. Also, in Dongyang medicine class, Dongho-go, the jade is changed into water when it is put into Omi-ji and Jiyuju, and it is good to eat if it is put in the jugui, and when it eats at the same size as the jade, the waste is discharged outside the body, It is said that it is called "aquatic oak" and it is called a "fresh oak" field when it is mixed with a sea bream, a sea bream, and a back oak into a copper bowl and cooks rice.

On the other hand, there has been no report on the preparation of cosmetics using such pomegranate and corn oil as raw materials, and the inventors of the present invention have manufactured functional cosmetics using these and have found excellent antioxidative activity.

Accordingly, the present invention can provide a cosmetic composition for improving oxidative stress comprising nephrite powder and corn oil as an active ingredient.

In particular, the inventors of the present invention manufactured a more harmless cosmetic composition through the process of removing harmful microorganisms present in the nephrite powder and the corn oil in the preparation of the cosmetic composition. The nephrite powder is obtained by pulverizing the nephrite gemstone, , And sterilized by steam heat at a temperature of 120 to 125 DEG C under a pressure of 2 to 3 atm for 20 to 30 minutes.

As a result of analyzing the contents of minerals contained in the nephrite powder and the corn oil, in the embodiment of the present invention, it was found that the corn oil contains abundantly various minerals such as Ca, Si, Mg, Na and K. In the nephrite powder, Mg, Ca, Si, K, and Na, which are found in the wastewater.

Accordingly, the cosmetic composition of the present invention, which contains nephrite powder and corn oil as a raw material rich in various minerals, can induce skin improving effects such as skin moisturizing, nutritional supply, and oxidative stress improvement.

The components contained in the cosmetic composition of the present invention may contain, as an active ingredient, components commonly used in cosmetic compositions in addition to the nephrite powder and the ointment, and may contain conventional components such as antioxidants, stabilizers, solubilizers, vitamins, Phosphorous additive, and carrier.

The cosmetic composition of the present invention can be prepared into any of the formulations conventionally produced in the art and can be used in the form of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, , Oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, the cosmetic composition of the present invention can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component . When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters. In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used. When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether. When the formulation of the present invention is a surfactant-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide ether Alkylamido betaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester.

In addition, the present invention can provide a cosmetic method which has an effect of protecting the skin from oxidative stress using a cosmetic composition comprising the nephrite powder and the corn oil as an active ingredient of the present invention.

The cosmetic process of the present invention refers to all cosmetic processes using the cosmetic composition of the present invention. That is, all methods known in the art using a cosmetic composition belong to the cosmetic method of the present invention. The cosmetic composition of the present invention may be used alone or in combination, or may be used in combination with other cosmetic compositions other than the present invention. The cosmetic composition according to the present invention may be used according to a conventional method of use, and may be used in a number of times depending on the skin condition or taste of the user.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation, it may be applied to the skin and then wiped off, washed or rinsed with water. The surfactant-containing cleansing formulation may be a cleansing foam, a cleansing water, a cleansing towel and a cleansing pack. The surfactant-free cleansing formulation may be a cleansing cream, , Cleansing lotion, cleansing water and cleansing gel, but is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are for further illustrating the present invention, and the scope of the present invention is not limited to these examples.

< Example  1>

The  And nephrite powder preparation

The nephrite powder was collected from Chuncheon Jade Mine. The nephrite gemstone was pulverized using a crusher and sterilized by heating at 200 ° C for 2 hours to remove harmful microorganisms contained in nephrite.

In order to remove harmful microorganisms, the collected oak water was also sterilized by steam heat at a temperature of 121 ° C for 20 minutes under a pressure of 15 pounds (2 atmospheres).

The cornstarch and the nephrite powder thus sterilized were subjected to mineral analysis through the following experiment and used in the manufacture of cosmetics.

< Example  2>

The  And minerals content in nephrite powder

The present inventors analyzed mineral contents contained in the corn starch and nephrite powder prepared in Example 1, which is an effective ingredient of the cosmetic composition of the present invention. Mineral content analysis was performed using ICP mass.

As a result of the analysis, it was confirmed that, as shown in Table 1, the corn starch of the present invention has almost the same composition and composition as the commercially available corn. In all of these, the specific gravity occupied by Ca, Si, Mg, Na, and K, and the composition ratio of Ca was 29.9 mg / L. It was confirmed that the nephrite powder used in the present invention contained Mg, Ca, Si, K, and Na found in the corn oil, and that Al not found in the corn oil had a Mg composition ratio (20,000 mg / kg) of 9,747 mg / kg Of the total amount.

< Example  2>

The  And heavy metal content in nephrite powder

The present inventors analyzed the heavy metal content of the corn starch and nephrite powder prepared in Example 1, and the heavy metal content was also analyzed using the ICP mass as in the mineral content analysis.

As a result of the analysis, as shown in Table 2, no heavy metal substance was detected in the corn oil used in the present invention, and no toxic heavy metal was detected in the nephrite powder. In the nephrite powder, Mn and Zn were contained and contained very small amounts of Cr, Pb and As, but it was not found to be harmful to human body.

< Example  3>

The  And nephrite powder Oxidative  Stress Inhibition Analysis

The present inventors analyzed the eradication efficacy of superoxide and nitrite to determine whether the corn starch and the nephrite powder of the present invention have free radical scavenging activity. First, 200 μL of 0.05 M phosphate buffer (pH 8.24) was mixed with 90 μL of the sample of each of the corn starch and nephrite powder of the present invention, and 10 μL of a solution prepared by dissolving in 10 mM HCl to a concentration of 3 mM was used for the superoxide- After incubation at room temperature for 10 minutes, centrifugation was performed at 3,000 xg for 10 minutes, and the absorbance at 420 nm was measured with the supernatant. In addition, nitrite scavenging activity was evaluated by adding 60 μL of each sample of the corn starch and nephrite powder of the present invention and 150 μL of Griess Reagent to a solution of 30 μL of 0.1 M citrate buffer (pH 3.0) and 6 μL of 50 μg / mL NaNO ₂ After incubation at room temperature for 10 minutes and centrifugation at 3,000 xg for 10 minutes, absorbance was measured at 538 nm with supernatant.

As a result of the analysis, as shown in FIG. 1 and FIG. 2, both the corn starch and the nephrite powder of the present invention were found to have an activity of effectively suppressing the production of superoxide and nitrite.

Therefore, the inventors of the present invention have found that cosmetic compositions having improved functionality capable of effectively protecting the skin from oxidative stress can be prepared by using the corn oil and the nephrite powder in cosmetic compositions.

< Example  4>

The  And cosmetics containing nephrite powder

① Skin Lotion

A skin lotion was prepared according to a conventional method by adding the following ingredients and contents.

All components (Korean) Content (% by weight) The 10.0 Nephrite powder 2.0 1,3-butylene glycol 5.2 Oleyl alcohol 1.5 ethanol 3.2 Polysorbate 20 3.2 Benzophenone 9 2.0 Carboxyl vinyl polymer 1.0 glycerin 3.5 incense 0.1 antiseptic 0.1 water to 100

② Essence

Essences were prepared according to a conventional method by adding the following ingredients and contents.

All components (Korean) Content (% by weight) The 15.0 Nephrite powder 2.0 Cetostearyl alcohol 1.0 Glyceryl monostearate 0.8 Sorbitan monostearate 0.3 Captophil paraben 0.1 Polysorbate 60 1.0 Mineral oil 5.0 Cyclomethicone 3.0 Dimethicone 0.5 Allantoin 0.1 glycerin 5.0 Alcohol 2.0 Propylene glycol 3.0 incense 0.1 antiseptic 0.1 water to 100

③ Body cleanser

A body cleanser was prepared according to a conventional method by adding the following components and contents.

All components (Korean) Content (% by weight) The 5.00 Nephrite powder 2.0 Alkyl ether sulphate (30%) 30.0 Alkylether sulfosuccinate (30%) 20.0 Alkylamido betaine (30%) 5.0 Propylene glycol 5.0 Betaine 5.0 Laura Midi Dei 4.0 Cellulose sword 0.05 Hydrolyzed protein 0.1 Citric acid 0.02 NaCl 0.02 incense 0.1 antiseptic 0.1 water to 100

④ Massage Pack

A massage pack was prepared according to a conventional method by adding the following ingredients and contents.

All components (Korean) INCI Name content
(weight%) The Nephrite Extract 47.09 Nephrite powder Nephrite powder 25.00 Carbomer Carbomer 11.00 Carrageenan Carrageenan 7.00 glycerin Glycerin 5.00 Dipropylene glycol Dipropylene Glycol 3.00 1,2-hexanediol 1,2-Hexanediol 1.00 Polysorbate 60 Polysorbate 60 0.80 Potassium hydroxide Potassium Hydroxide 0.09 Ethylhexyl Glycerin Ethylhexylglycerin 0.02 Total content 100.00

< Example  5>

Skin stability test

Thirty two men and women were selected for the nephrite powder, which is the main ingredient used in the cosmetic production of the present invention, and the skin stability test for the nephrite powder ampoule was conducted. In the stability test, the degree of skin irritation was checked at 30 minutes, 24 hours, and 48 hours after the removal of the information. In addition, a skin stability test was also conducted on the corn oil. The skin irritation degree of 30 days, 24 hours, and 48 hours after the treatment of corn oil to the same adult male and female were analyzed.

As a result of the analysis, as shown in Tables 7 and 8 below, most of the tester did not induce skin irritation. Therefore, the inventors of the present invention found that the nephrite powder and the ointment of the present invention do not cause toxicity to the skin, and thus can be used as a raw material for functional cosmetics having excellent skin stability.

The present invention has been described with reference to the preferred embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.

Claims (5)

A cosmetic composition for improving oxidative stress comprising nephrite powder and corn starch as active ingredients. The method according to claim 1,
Wherein the nephrite powder is powdered and then sterilized by heating at 200 to 250 DEG C for 2 to 3 hours. The method according to claim 1,
Wherein the corn starch is sterilized with steam at a temperature of 120 to 125 DEG C under a pressure of 2 to 3 atm for 20 to 30 minutes. The method according to claim 1,
The composition may be in the form of a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, a nutrition cream, a moisturizing cream, a hand cream, Wherein the composition is formulated as one selected from the group consisting of cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, lipstick, makeup base, foundation, press powder and loose powder. A cosmetic method characterized by having the effect of applying the cosmetic composition of claim 1 to human skin to reduce the oxidative stress of the skin.

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