KR20180107151A - Tgf베타 2 항체 - Google Patents

Tgf베타 2 항체 Download PDF

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Publication number
KR20180107151A
KR20180107151A KR1020187023260A KR20187023260A KR20180107151A KR 20180107151 A KR20180107151 A KR 20180107151A KR 1020187023260 A KR1020187023260 A KR 1020187023260A KR 20187023260 A KR20187023260 A KR 20187023260A KR 20180107151 A KR20180107151 A KR 20180107151A
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KR
South Korea
Prior art keywords
seq
tgf
antibody
chain variable
variable region
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Withdrawn
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KR1020187023260A
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English (en)
Korean (ko)
Inventor
치?두 이베분조
카르슈텐 자코비
안젤리카 마이어
에벨리네 샤트
앤-울리크 트렌델렌버그
올가 블라디미로프나 미티나
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노파르티스 아게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58191507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20180107151(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20180107151A publication Critical patent/KR20180107151A/ko
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020187023260A 2016-02-17 2017-02-17 Tgf베타 2 항체 Withdrawn KR20180107151A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662296282P 2016-02-17 2016-02-17
US62/296,282 2016-02-17
PCT/IB2017/050917 WO2017141208A1 (en) 2016-02-17 2017-02-17 Tgfbeta 2 antibodies

Publications (1)

Publication Number Publication Date
KR20180107151A true KR20180107151A (ko) 2018-10-01

Family

ID=58191507

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187023260A Withdrawn KR20180107151A (ko) 2016-02-17 2017-02-17 Tgf베타 2 항체

Country Status (21)

Country Link
US (1) US11180546B2 (OSRAM)
EP (1) EP3416982A1 (OSRAM)
JP (1) JP2019511911A (OSRAM)
KR (1) KR20180107151A (OSRAM)
CN (1) CN108699142A (OSRAM)
AU (1) AU2017219254B2 (OSRAM)
BR (1) BR112018015690A2 (OSRAM)
CA (1) CA3012294A1 (OSRAM)
CL (1) CL2018001941A1 (OSRAM)
CO (1) CO2018008590A2 (OSRAM)
CU (1) CU20180088A7 (OSRAM)
EA (1) EA201891724A1 (OSRAM)
EC (1) ECSP18064646A (OSRAM)
HK (1) HK1257455A1 (OSRAM)
IL (1) IL261065A (OSRAM)
MA (1) MA44236A (OSRAM)
MX (1) MX2018010021A (OSRAM)
PH (1) PH12018501525A1 (OSRAM)
RU (1) RU2018131123A (OSRAM)
SG (1) SG11201805941WA (OSRAM)
WO (1) WO2017141208A1 (OSRAM)

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CA3108949A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
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CA3118027A1 (en) * 2018-11-05 2020-05-14 Ludwig Institute For Cancer Research Ltd. Humanized and variant tgf-.beta.3 specific antibodies and methods and uses thereof
WO2020257639A1 (en) 2019-06-21 2020-12-24 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
CA3152371A1 (en) 2019-08-01 2021-02-04 Vaccinex, Inc. Combined inhibition of semaphorin-4d and tgf.beta. and compositions therefor
WO2021163369A2 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of treating age-related and inflammatory diseases
CA3169243A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
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US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
KR20230146032A (ko) 2021-02-15 2023-10-18 다케다 야쿠힌 고교 가부시키가이샤 Tgf-b 신호전달을 조절하기 위한 세포 치료 조성물 및 방법
CN112940119B (zh) * 2021-04-26 2022-05-20 北京芳渟阳生生物科技有限公司 一种单克隆抗体及其与间充质干细胞外泌体的联合应用
WO2023201310A1 (en) 2022-04-13 2023-10-19 HCW Biologics, Inc. Multi-chain chimeric polypeptide for use in the treatment of circardian clock gene disorder
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Also Published As

Publication number Publication date
SG11201805941WA (en) 2018-09-27
WO2017141208A1 (en) 2017-08-24
CA3012294A1 (en) 2017-08-24
RU2018131123A3 (OSRAM) 2020-07-09
JP2019511911A (ja) 2019-05-09
AU2017219254A1 (en) 2018-08-02
MX2018010021A (es) 2018-11-09
US20190092846A1 (en) 2019-03-28
EA201891724A1 (ru) 2019-01-31
CU20180088A7 (es) 2019-05-03
CL2018001941A1 (es) 2018-09-07
BR112018015690A2 (pt) 2018-12-26
US11180546B2 (en) 2021-11-23
AU2017219254B2 (en) 2019-12-12
CN108699142A (zh) 2018-10-23
IL261065A (en) 2018-10-31
HK1257455A1 (zh) 2019-10-18
ECSP18064646A (es) 2018-09-30
RU2018131123A (ru) 2020-03-17
PH12018501525A1 (en) 2019-03-18
EP3416982A1 (en) 2018-12-26
CO2018008590A2 (es) 2018-08-21
MA44236A (fr) 2018-12-26

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PA0105 International application

Patent event date: 20180813

Patent event code: PA01051R01D

Comment text: International Patent Application

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