KR20180083942A - 1,3,4-티아디아졸 화합물 및 암 치료시 이의 용도 - Google Patents
1,3,4-티아디아졸 화합물 및 암 치료시 이의 용도 Download PDFInfo
- Publication number
- KR20180083942A KR20180083942A KR1020187018472A KR20187018472A KR20180083942A KR 20180083942 A KR20180083942 A KR 20180083942A KR 1020187018472 A KR1020187018472 A KR 1020187018472A KR 20187018472 A KR20187018472 A KR 20187018472A KR 20180083942 A KR20180083942 A KR 20180083942A
- Authority
- KR
- South Korea
- Prior art keywords
- methoxy
- phenyl
- acetamide
- thiadiazol
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CCC=*C(C)C(CC1)CC1C(C1)[C@@]1(C)C(CC)=CC Chemical compound CCC=*C(C)C(CC1)CC1C(C1)[C@@]1(C)C(CC)=CC 0.000 description 9
- BVXKPJNFBXKDMN-FOIQADDNSA-N CO[C@@H](C(Nc1nnc(N[C@H](CC2)CN2c(cc2)nnc2F)[s]1)=O)c1cc(N(C2)CC2OC)ccc1 Chemical compound CO[C@@H](C(Nc1nnc(N[C@H](CC2)CN2c(cc2)nnc2F)[s]1)=O)c1cc(N(C2)CC2OC)ccc1 BVXKPJNFBXKDMN-FOIQADDNSA-N 0.000 description 1
- BVXKPJNFBXKDMN-QRWLVFNGSA-N CO[C@H](C(Nc1nnc(N[C@H](CC2)CN2c(cc2)nnc2F)[s]1)=O)c1cc(N(C2)CC2OC)ccc1 Chemical compound CO[C@H](C(Nc1nnc(N[C@H](CC2)CN2c(cc2)nnc2F)[s]1)=O)c1cc(N(C2)CC2OC)ccc1 BVXKPJNFBXKDMN-QRWLVFNGSA-N 0.000 description 1
- ORJYDQMXUNVTGW-ZCFIWIBFSA-N Nc1nnc(N[C@H](CC2)CN2c(cc2)nnc2F)[s]1 Chemical compound Nc1nnc(N[C@H](CC2)CN2c(cc2)nnc2F)[s]1 ORJYDQMXUNVTGW-ZCFIWIBFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260789P | 2015-11-30 | 2015-11-30 | |
| US62/260,789 | 2015-11-30 | ||
| PCT/EP2016/079250 WO2017093299A1 (en) | 2015-11-30 | 2016-11-30 | 1,3,4-thiadiazole compounds and their use in treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180083942A true KR20180083942A (ko) | 2018-07-23 |
Family
ID=57485461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187018472A Withdrawn KR20180083942A (ko) | 2015-11-30 | 2016-11-30 | 1,3,4-티아디아졸 화합물 및 암 치료시 이의 용도 |
Country Status (24)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201520959D0 (en) | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
| US9938265B2 (en) | 2015-11-30 | 2018-04-10 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| TW201731511A (zh) * | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | １，３，４-噻二唑化合物及其在治療癌症中之用途 |
| US10323028B2 (en) | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| CN110741003B (zh) * | 2017-06-13 | 2021-07-23 | 南京明德新药研发有限公司 | 作为gls1抑制剂的化合物 |
| ES2939506T3 (es) | 2018-10-16 | 2023-04-24 | Medshine Discovery Inc | Derivado de tiadiazol y usos del mismo como inhibidor de GLS1 para el tratamiento de cáncer |
| WO2025196446A1 (en) * | 2024-03-22 | 2025-09-25 | Sitryx Therapeutics Limited | Thiadiazoles as glutaminase 1 inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451828B1 (en) * | 2000-08-10 | 2002-09-17 | Elan Pharmaceuticals, Inc. | Selective inhibition of glutaminase by bis-thiadiazoles |
| CN108785305B (zh) * | 2011-11-21 | 2021-10-29 | 卡利泰拉生物科技公司 | 谷氨酰胺酶的杂环抑制剂 |
| HUE056078T2 (hu) * | 2012-11-16 | 2022-01-28 | Calithera Biosciences Inc | Heterociklusos glutamináz inhibitorok |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| KR20160100407A (ko) | 2014-01-06 | 2016-08-23 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 글루타미나제의 저해제 |
| WO2015138902A1 (en) * | 2014-03-14 | 2015-09-17 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| GB201409624D0 (en) | 2014-05-30 | 2014-07-16 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| GB201520959D0 (en) | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
| US9938265B2 (en) * | 2015-11-30 | 2018-04-10 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| TW201731511A (zh) | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | １，３，４-噻二唑化合物及其在治療癌症中之用途 |
| US10323028B2 (en) | 2015-11-30 | 2019-06-18 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
-
2016
- 2016-11-29 US US15/363,030 patent/US10323028B2/en active Active
- 2016-11-29 TW TW105139337A patent/TW201733587A/zh unknown
- 2016-11-30 PE PE2018001001A patent/PE20181565A1/es unknown
- 2016-11-30 BR BR112018010806-5A patent/BR112018010806A2/en not_active Application Discontinuation
- 2016-11-30 MX MX2018006532A patent/MX2018006532A/es unknown
- 2016-11-30 SG SG11201803810XA patent/SG11201803810XA/en unknown
- 2016-11-30 AU AU2016363718A patent/AU2016363718B2/en not_active Ceased
- 2016-11-30 RU RU2018123714A patent/RU2018123714A/ru not_active Application Discontinuation
- 2016-11-30 WO PCT/EP2016/079250 patent/WO2017093299A1/en not_active Ceased
- 2016-11-30 JP JP2018526716A patent/JP6999550B2/ja active Active
- 2016-11-30 AR ARP160103663A patent/AR106874A1/es unknown
- 2016-11-30 CA CA3005495A patent/CA3005495C/en active Active
- 2016-11-30 EA EA201891241A patent/EA201891241A1/ru unknown
- 2016-11-30 ES ES16806028T patent/ES2914333T3/es active Active
- 2016-11-30 EP EP16806028.3A patent/EP3383873B1/en active Active
- 2016-11-30 CN CN201680067245.3A patent/CN108349966B/zh active Active
- 2016-11-30 KR KR1020187018472A patent/KR20180083942A/ko not_active Withdrawn
- 2016-11-30 TN TNP/2018/000127A patent/TN2018000127A1/en unknown
-
2018
- 2018-05-22 IL IL259510A patent/IL259510A/en unknown
- 2018-05-24 CL CL2018001407A patent/CL2018001407A1/es unknown
- 2018-05-29 SV SV2018005702A patent/SV2018005702A/es unknown
- 2018-05-29 PH PH12018501131A patent/PH12018501131A1/en unknown
- 2018-05-29 NI NI201800064A patent/NI201800064A/es unknown
- 2018-06-29 CO CONC2018/0006928A patent/CO2018006928A2/es unknown
-
2019
- 2019-05-03 US US16/402,825 patent/US10981904B2/en active Active
-
2021
- 2021-04-15 US US17/231,164 patent/US11753405B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11753405B2 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| US10294221B2 (en) | 1, 3, 4-thiadiazole compounds and their use in treating cancer | |
| KR20180083411A (ko) | 1,3,4-티아디아졸 화합물 및 암 치료시 이의 용도 | |
| CA3005516C (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| US10577354B2 (en) | Bis-pyridazine compounds and their use in treating cancer | |
| HK1260708B (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1260708A1 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1260702B (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1260702A1 (en) | 1,3,4-thiadiazole compounds and their use in treating cancer | |
| HK1232529A1 (en) | 1, 3, 4-thiadiazole compounds and their use in treating cancer | |
| HK1232529B (en) | 1, 3, 4-thiadiazole compounds and their use in treating cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20180628 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |