KR20180064387A - 포스포이노시티드 3-키나제 저해제 및 제2 항증식제를 포함하는 조성물 - Google Patents

포스포이노시티드 3-키나제 저해제 및 제2 항증식제를 포함하는 조성물 Download PDF

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Publication number
KR20180064387A
KR20180064387A KR1020187007564A KR20187007564A KR20180064387A KR 20180064387 A KR20180064387 A KR 20180064387A KR 1020187007564 A KR1020187007564 A KR 1020187007564A KR 20187007564 A KR20187007564 A KR 20187007564A KR 20180064387 A KR20180064387 A KR 20180064387A
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composition
kit
alkyl
inhibitors
inhibitor
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Korean (ko)
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스티븐 조셉 셔틀워스
앤드류 데이비드 웨일
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카루스 떼라퓨틱스 리미티드
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Publication of KR20180064387A publication Critical patent/KR20180064387A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020187007564A 2015-08-19 2016-08-19 포스포이노시티드 3-키나제 저해제 및 제2 항증식제를 포함하는 조성물 Withdrawn KR20180064387A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1514760.6A GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use
GB1514760.6 2015-08-19
PCT/GB2016/052575 WO2017029517A1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent

Publications (1)

Publication Number Publication Date
KR20180064387A true KR20180064387A (ko) 2018-06-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187007564A Withdrawn KR20180064387A (ko) 2015-08-19 2016-08-19 포스포이노시티드 3-키나제 저해제 및 제2 항증식제를 포함하는 조성물

Country Status (22)

Country Link
US (3) US10668077B2 (https=)
EP (1) EP3337477B1 (https=)
JP (1) JP2018523689A (https=)
KR (1) KR20180064387A (https=)
CN (2) CN113786409B (https=)
AU (1) AU2016307885B2 (https=)
CA (1) CA2995898A1 (https=)
DK (1) DK3337477T3 (https=)
ES (1) ES2939815T3 (https=)
FI (1) FI3337477T3 (https=)
GB (1) GB201514760D0 (https=)
HR (1) HRP20230376T1 (https=)
HU (1) HUE061615T2 (https=)
IL (1) IL257499A (https=)
LT (1) LT3337477T (https=)
MX (1) MX2018001926A (https=)
PL (1) PL3337477T3 (https=)
PT (1) PT3337477T (https=)
RS (1) RS64095B1 (https=)
SI (1) SI3337477T1 (https=)
SM (1) SMT202300063T1 (https=)
WO (1) WO2017029517A1 (https=)

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GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
CN113164466B (zh) * 2018-09-11 2025-07-08 柯瑞斯公司 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗
WO2020059705A1 (ja) * 2018-09-18 2020-03-26 株式会社ヤクルト本社 キノリンカルボキサミド誘導体を用いるがん併用療法
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CN111904958B (zh) * 2019-05-09 2022-09-13 浙江大学 Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用
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CN114533879B (zh) * 2020-11-19 2023-09-29 广州顺健生物医药科技有限公司 治疗癌症的联合疗法

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Publication number Publication date
DK3337477T3 (en) 2023-02-20
US20180243313A1 (en) 2018-08-30
EP3337477A1 (en) 2018-06-27
ES2939815T3 (es) 2023-04-27
US10668077B2 (en) 2020-06-02
GB201514760D0 (en) 2015-09-30
CN108348505A (zh) 2018-07-31
LT3337477T (lt) 2023-03-10
AU2016307885A1 (en) 2018-03-08
PT3337477T (pt) 2023-03-20
PL3337477T3 (pl) 2023-07-03
HK1251467A1 (en) 2019-02-01
JP2018523689A (ja) 2018-08-23
CA2995898A1 (en) 2017-02-23
AU2016307885B2 (en) 2019-07-25
US12257254B2 (en) 2025-03-25
FI3337477T3 (fi) 2023-04-27
CN108348505B (zh) 2021-10-12
IL257499A (en) 2018-07-31
RS64095B1 (sr) 2023-04-28
EP3337477B1 (en) 2023-02-01
HRP20230376T1 (hr) 2023-06-23
HUE061615T2 (hu) 2023-07-28
MX2018001926A (es) 2018-06-19
CN113786409A (zh) 2021-12-14
CN113786409B (zh) 2024-04-02
US20230066999A1 (en) 2023-03-02
WO2017029517A1 (en) 2017-02-23
US20210069200A1 (en) 2021-03-11
US11291669B2 (en) 2022-04-05
SI3337477T1 (sl) 2023-04-28
SMT202300063T1 (it) 2023-03-17

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Patent event date: 20180316

Patent event code: PA01051R01D

Comment text: International Patent Application

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WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid