KR20180062813A - Composition for preventing or improving axillary osmidrosis - Google Patents

Abstract

According to an embodiment of the present invention, provided are a cosmetic composition and a quasi-drug composition for preventing or ameliorating osmidrosis, containing a mixture composed of 200-450 parts by weight of glucose with respect to 100 parts by weight of sodium chloride as an active ingredient.

Description

TECHNICAL FIELD The present invention relates to a composition for preventing or improving odor,

The present invention relates to a composition for quasi-drugs and a composition for cosmetics for preventing or ameliorating atherosclerosis. More specifically, the present invention relates to a composition for quasi-drugs and a composition for cosmetics for preventing or ameliorating osteoporosis which can be produced economically, And a composition for cosmetics.

Bromidrosis, also known as drunkenness or cancer, is common in postpubertal. Some osteoporosis is so severe that oozing is so severe that the lives of individuals are seriously hampered, and this is serious enough to be recognized as pathological. Oozing is usually a chronic condition in which an excessive unpleasant odor emanates from the skin. This condition is usually determined by apocrine gland secretion and can substantially impair an individual's quality of life.

The secretory gland is divided into two main types, apocrine and eccrine. The eccrine gland is distributed throughout the surface of the skin and is involved in the regulation of body temperature by sweat production. In contrast, apocrine glands have a finite distribution, including underarms, genital skin and breast. Apocrine elements are also found in the periorbital and periauricular sites. The apocrine line has no thermoregulatory function, but it causes a characteristic pheromonal odor.

In general, the odor of the skin is due to the fact that the substance secreted from the apocrine glands of the two types of sweat glands, apocrine glands and eccrine glands, which are present in the human body, is decomposed by Gram-positive bacteria on the skin surface. The chemistry of apocrine sweat glands may have individual differences, so the odor of the patient may be slightly different, and sweat secretions that cause bad odors in hair and clothes may accumulate and worsen the odor.

Treatment methods of apocrine ooze include removal of apocrine secretion from the skin surface, inhibition of the growth of bacteria, induction of adsorption or change of odor causing substance, and removal of odor by perfume, etc., often washed with soap, It is also a good idea to remove hair. Local antibiotics such as neomycin and gentamicin can also be used effectively. If the method does not work in this way, the area where the apocrine sweat glands are distributed may be excised surgically. In addition to such cleansing, perfuming, or local perfume, various medicines, quasi-drugs, or cosmetic compositions have been developed to treat osteoporosis.

Patent Document 1 discloses a process for producing 2-cyclohexylidene-2-phenylacetonitrile and 3,8,8,11a-tetramethyldodecahydro-5H-3,5a-epoxy-naphtho [2,1- Discloses a malodor neutralizing composition comprising sebacic acid.

Patent Document 2 discloses a composition for removing an intestine containing a mixture in which 25 to 35 g of salicylic acid in powder form is mixed and dissolved in 70 to 80% of 1 L of ethanol.

Various compositions have been developed to treat osteoporosis. However, due to the characteristics of modern society where image making is important, there is a continuing need to develop a composition for preventing or improving osteoporosis which is effective and easy to use.

1. Korean Patent Publication 2013-0132848 2. Korean Patent Publication 2016-0021166

It is an object of the present invention to provide a composition for quasi-drugs for preventing or ameliorating osteoporosis which can be produced not only irritatingly but immediately after use as well as economically.

Another object of the present invention is to provide a cosmetic composition for preventing or ameliorating osteoporosis that can be produced economically as well as exhibiting an immediate effect after use without being irritating.

One aspect of the present invention provides a quasi-drug composition for prevention or improvement of an arousal syndrome, which comprises, as an active ingredient, a mixture of 200-450 parts by weight of glucose relative to 100 parts by weight of sodium chloride.

In another aspect of the present invention, there is provided a cosmetic composition for preventing or improving odor, which comprises, as an active ingredient, a mixture of 200-450 parts by weight of glucose relative to 100 parts by weight of sodium chloride.

According to one aspect of the present invention, the composition for quasi-drugs and the composition for cosmetics for preventing or ameliorating atherosclerosis do not contain irritating ingredients and can be applied to the armpit area very comfortably and can exhibit an immediate effect after use. It is very convenient to do. In addition, there is an advantage that the composition contains no expensive components and can be manufactured very economically.

Hereinafter, the present invention will be described in more detail.

All technical terms used in the present invention are used in the sense that they are generally understood by those of ordinary skill in the relevant field of the present invention unless otherwise defined. In addition, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. Also, the numerical values set forth herein are considered to include the meaning of " about " unless explicitly stated. The contents of all publications referred to in this specification are incorporated herein by reference in their entirety.

The present inventors have studied a composition for the prevention or amelioration of otitis externa that is not irritating and can be economically produced. As a result, it has been found that when applied to the armpit, a composition combining glucose in addition to salt, which has been traditionally known to be effective in the treatment of arousal, is very effective in removing osteoporosis and has an immediate effect. The effect was remarkably improved.

One aspect of the present invention provides a quasi-drug composition for prevention or improvement of an arousal syndrome, which comprises, as an active ingredient, a mixture of 200-450 parts by weight of glucose relative to 100 parts by weight of sodium chloride.

In another aspect of the present invention, there is provided a cosmetic composition for preventing or improving odor, which comprises, as an active ingredient, a mixture of 200-450 parts by weight of glucose relative to 100 parts by weight of sodium chloride.

As used herein, the term " fever "refers to any disease that stinks in the human underarms after puberty, including apcarnia.

Hereinafter, the composition for quasi-drugs and the composition for cosmetics according to the present invention are also referred to as "composition according to the present invention ".

As a result of the test, the composition according to the present invention was applied to a person having an arousal, and it was confirmed that the smell was immediately alleviated immediately upon application, and it was effective even when applied regularly every day. In addition, the composition according to the present invention has a synergistic effect as compared with a composition containing only salt or a composition containing only glucose. Thus, a very immediate, sustained and effective reduction of the odor loss and preventive effects were confirmed (see Test Examples 1 and 2).

Furthermore, since the composition according to the present invention uses extremely inexpensive salt and glucose as an effective ingredient, it can be manufactured at a very low unit cost, and has an advantage of being excellent in economical efficiency.

The composition according to the present invention can be used for both men and women after puberty.

The composition according to the present invention may be suitably formulated together with a pharmaceutically or cosmetically acceptable carrier.

The pharmaceutical composition may be formulated as a topical preparation, for example, as a topical liquid, ointment, lotion, gel, cream, or spray, but is not limited thereto.

The cosmetic composition may be formulated into any cosmetic formulations and may be formulated, for example, as a topical liquid, ointment, lotion, gel, cream, or spray, but is not limited thereto.

Such optional quasi-drug formulations or cosmetic formulations with carriers and additives required for formulation are well known to those skilled in the art.

In one embodiment, a composition according to the present invention may comprise one or more pharmaceutically acceptable or cosmetically acceptable excipients such as preservatives, aromas, pH-adjusting agents, or any combination thereof .

Examples of such excipients include, as preservatives, sodium benzoate, benzalkonium chloride, methyl parahydroxybenzoate, propyl para hydroxy benzoate; As the pH-adjusting agent, citric acid, ascorbic acid, or tartaric acid may be used.

The fragrance may be any directional agent which is known to be usable in quasi-drugs or cosmetic compositions and harmless to the human body. In one embodiment, the perfume can be an orange, lemon, soft caramel, and / or vanilla / lemon flavor.

Additional examples of excipients, including fragrances, are described in S. S. et al. Arctander, Perfume and Flavor Chemicals (Montclair, N. J., 1969); [S. Arctander, Perfume and Flavor Materials of Natural Origin (Elizabeth, N. J., 1960); [S. Arctander, 'Perfume and Flavor Chemicals', Vol. I and II, Allured Publishing Corporation, Carol Stream, 1994], and Can be found in [JM Nikitakis (Ed.), 'CTFA Cosmetic Ingredient Handbook', 1st ed., The Cosmetic, Toiletry and Fragrance Association, Inc., Washington,

In one embodiment, the composition according to the present invention may be prepared in the form of a temperature sensitive topical gel which is liquid at room temperature and which forms a gel when applied to the armpits and is easy to adhere to the underarm skin.

In one embodiment, the composition according to the present invention may have a form of a topical liquid or gel, and the liquid or gel may have a form applied to a rollerball applicator. Methods of making in the form of roller ball applicators are well known in the art.

In one embodiment, the composition according to the present invention may be formulated in the form of a spray.

Methods of preparing such topical formulations and the carriers and additives used in the preparation of topical formulations are described in detail in Remington's Pharmaceutical Sciences (19th ed., 1995). In particular, a method for producing a thermosensitive gel can be found, for example, in Korean Patent Publication No. 2004-0028336.

The active ingredient in the composition according to the present invention may be contained in an amount of 1 to 90% by weight based on the final composition. When the content of the active ingredient is 50% by weight or more, it may be diluted with water according to the severity of symptoms. When diluted, it is usually used by diluting it to about 0.5 to 5 times of water.

The composition according to the present invention can be applied in such a manner that a predetermined amount is applied to the armpit area and then wiped off. The time for which the composition is applied to the axillary area and then allowed to stand is not particularly limited, and the applicant can appropriately adjust it in terms of simplicity of use and maximization of effect. If the application time is shortened, the treatment time is quickly terminated. Therefore, the effect of improving the odor can be further enhanced by increasing the application time.

In one embodiment, the composition according to the present invention may be immediately wiped off, or may be left to stand for 10 minutes or less and then wiped with a towel or wiped with water. In order to increase the effect, it is preferable to leave it for 5 minutes or more if possible. However, it may be applied for simplicity and then wiped off or left for 5 minutes or less.

The amount to be applied may vary depending on the formulation of the composition according to the present invention, but may be applied so as to have a dose of 0.01 to 100 mg per axilla based on the active ingredient. It should be understood that the amount applied and the time of application should be determined in light of various relevant factors such as the severity of the atrophy and the amount applied is not intended to limit the scope of the invention in any way

Hereinafter, the present invention will be described in detail based on the following examples. However, the following examples are intended to illustrate the present invention, but the scope of the present invention is not limited thereto.

Example 1

Preparation of thermosensitive gel for preventing or improving odor

Polycarbophil was dissolved in pH 7.0 buffer at room temperature in the composition shown in the following Table 1, cooled, and poloxamer was added at 4. This solution was allowed to stand in a refrigerator for one day, and the active ingredient composition was dissolved in a mixture of ethanol and polyethylene glycol and dissolved in the poloxamer solution at 4 to prepare a temperature-sensitive gel for improving the odor.

[Table 1] (Unit: g)

The active ingredient composition was prepared by mixing 100 g of sodium chloride and 200 g of glucose (1: 2 w / w).

Comparative Examples 1 and 2

Comparative Example 2 was prepared in the same manner as in Example 1 except that only sodium chloride was used as the active ingredient composition and Comparative Example 2 was used in which only glucose was used as the active ingredient composition.

Example 2

Manufacture of topical solution for preventing or improving odor

To 50 g of the active ingredient composition, distilled water was added to 100 g to prepare a local solution for preventing or improving odor. The active ingredient composition was prepared by mixing 20 g of sodium chloride and 800 g of glucose (1: 4 w / w).

Comparative Examples 3 and 4

Comparative Example 3 was prepared in the same manner as in Example 2 except that only sodium chloride was used as the active ingredient composition and Comparative Example 4 was used in which only glucose was used as the active ingredient composition.

Test Example 1: Assessment of intestinal, intestinal and specific odor inhibitory efficacy (1)

For the compositions of Example 1 and Comparative Examples 1 and 2, the deodorization value test as generally described in US Patent No. 4278658 was used to test the MOC (deodorization) properties in the underarm product. Tests were carried out on people with fever; Approximately 1 g of each side was applied to each person, left for about 1 minute, and wiped with a towel.

A separate, skilled assessor was assessed in a manner that directly underlined the smell. The odor intensity grades used ranged from 0 to 5, with 5 being the highest level of odor and 0 being no odor, and the intensity was fixed with a standard solution containing a certain concentration of malodorous acid, isovaleric acid See Table 2).

[Table 2]

Each sampled composition was subjected to an odor intensity of 0 to 5, i.e., a deodorization-test score (DTS). The odor control value (MIV) of the composition was then calculated using the DTS in Equation (1) below.

[Equation 1]

MIV = (DTSc - DTS) / DTSc

In the above formula, DTSc is the average odor score indicated by a control group containing no aromatic compound.

According to the test results, the composition according to the present invention was significantly superior in deodorizing effect as compared with the comparative example, and had a synergistic deodorizing effect as compared with Comparative Examples 1 and 2. In addition, it was confirmed that the deodorizing effect was very excellent despite the application time of only one minute.

Thus, it has been confirmed that the composition according to the present invention has an excellent deodorizing effect while showing an immediate effect after use.

Test Example 2: Assessment of the effect of inhibiting the intestinal lupus,

The compositions of Example 3 and Comparative Examples 3 and 4 were tested in the same manner as in Test Example 1 above. For each person, apply about 1 g to the armpit, leave it for about 1 minute, wipe it with a towel, and let it perform twice a day for 1 week. Then, after 2 hours from the last application on the 7th day, And evaluated in the manner of their own.

According to the test results, the composition according to the present invention was significantly superior in deodorizing effect as compared with the comparative example, and had a synergistic deodorizing effect as compared with Comparative Examples 3 and 4. In addition, it was confirmed that the deodorizing effect is very good even after sufficient time has passed since the application in the case of regular application.

Therefore, it has been confirmed that the composition according to the present invention has a continuous deodorizing effect when used continuously.

The present invention has been described with reference to the preferred embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the above-described embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.

Claims (10)

A composition for quasi-drug use for prevention or improvement of an arousal, comprising a mixture of 200 to 450 parts by weight of glucose per 100 parts by weight of sodium chloride as an active ingredient. The quasi-drug composition according to claim 1, wherein the odor is male or female odor. The composition for quasi-drug according to claim 1, which is a topical liquid, ointment, lotion, gel, cream, or spray. The quasi-drug composition according to claim 3, which is formulated as a temperature-responsive gel. The quasi-drug composition according to claim 3, wherein the topical liquid or gel is applied to a roller ball applicator. A composition for a cosmetic use for prevention or improvement of odor, comprising a mixture of 200 to 450 parts by weight of glucose per 100 parts by weight of sodium chloride as an active ingredient. The cosmetic composition according to claim 6, wherein the odor is male or female odor. The cosmetic composition according to claim 6, which is a topical liquid, ointment, lotion, gel, cream, or spray. The cosmetic composition according to claim 8, which is formulated as a temperature-responsive gel. The cosmetic composition according to claim 8, wherein the topical liquid or gel is applied to a roller ball applicator.