KR20180046801A - COMPOSITION FOR PREVENTING OR ALLEVIATING HANGOVER COMPRISING EXTRACTS OF GINGSENG BERRY, EXTRACTS OF Hovenia dulcis Thunberg AND MINERRAL CONCENTRATE - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for preventing alcoholic hangover or alleviating hangover comprising a ginseng berry extract, a Hovenia dulcis Thunberg extract, and a mineral concentrate as effective components. Additionally, the present invention relates to a food composition for alleviating alcoholic hangover containing a ginseng berry extract, a Hovenia dulcis Thunberg extract, and a mineral concentrate.

Description

Technical Field [0001] The present invention relates to a composition for prevention or elimination of hangover, which comprises a ginseng fruit extract, a root extract and a mineral concentrate, and a composition for preventing or eliminating a hangover. BACKGROUND OF THE INVENTION 1. Field of the Invention [0002]

The present invention relates to a pharmaceutical composition for the prevention of alcoholic hangover or hangover comprising an extract of ginseng fruit, an extract of a canola and a bottle, and a mineral concentrate as an active ingredient, and a food composition for improving alcoholic hangover comprising a ginseng fruit extract, a canola extract and a mineral concentrate will be.

Hangover after drinking means in the dictionary meaning that the next day is unbreakable, that is, long - lasting stiffness. In modern life, people are often used to drink alcohol in a busy daily life for a variety of reasons, such as colleagues, family harmony, and affection, and long - lasting drinking can cause a hangover, which may have a negative impact on various social role participation .

Symptoms of hangover include headache, diarrhea, anorexia, nausea, vomiting, chills, and cold sweating after drinking alcohol. Objective symptoms include cognitive decline, decreased exercise capacity, hematologic changes, and hormonal changes. The cause of hangover is known to be dehydration, toxicity of alcohol and alcohol metabolites (acetaldehyde, formaldehyde, acetone, etc.), nutrient deficiency (blood sugar, vitamin, mineral deficiency) The degree of hangover is very different according to the variation of individuals due to heredity, environmental condition (nutrition, exercise, dehydration, health).

Alcohol after drinking alcohol is metabolized through three pathways. When the concentration of ethanol is low, by the action of the alcohol dehydrogenase and acetaldehyde dehydrogenase, which are present in the gastrointestinal tract or liver, It is metabolized to acetaldehyde and acetic acid by the microsomal ethanol oxidizing system (MEOS) present in the endoplasmic reticulum. Afterwards, the catalase activity in the peroxisome leads to carbon dioxide (CO ₂ ) And water (H ₂ O).

When an appropriate amount of alcohol is introduced, the metabolic system described above smoothly works, so that the symptoms caused by alcohol do not occur. However, when a large amount of alcohol is introduced, the balance of the metabolic system is destroyed and the body homeostasis can not be maintained. In the short term, Perspiration, loss of concentration, heartburn and indigestion, and liver dysfunction may occur in the long term.

Due to frequent drinking and drinking, which is characteristic of drinking culture in Korea, many people are showing high interest in drugs or drinks that can eliminate hangovers. In order to solve this hangover problem, various beverages and functional foods have been increasingly used. Domestic market sizes are 60 billion (2005), 114 billion (2008), 205.8 billion (11 years), 196.6 billion Year).

The present commercial hangover beverage is composed of three components: (1) a condition (CJ) using a lotus seed, a lotus seed, a lotus seed, a rice embryo and a hinoki extract; A large number of beverages are on the market, mainly from Care (Dong-A Pharm), Duckwood, and Daehan 808 (Grammy) using Raspberry Extract.

However, modern people have many wrong drinking habits in order to relieve the many stresses in daily life. Excessive alcohol consumption leads to hangover such as headache, diarrhea and vomiting next day, which causes many troubles in daily life do. However, modern drinking culture is indispensable factor. In this context, an effective solution is needed to resolve the symptoms of hangover.

It is an object of the present invention to provide a pharmaceutical composition for the prevention of an alcoholic hangover or a hangover containing an extract of a ginseng fruit, an extract of a canola and a bottle, and a mineral concentrate as an active ingredient.

It is still another object of the present invention to provide a food composition for improving alcoholic hangover, which comprises ginseng fruit extract, hull and bottle extract, and mineral concentrate.

It is still another object of the present invention to provide a method for preparing an alcoholic hangover or a pharmaceutical composition for the removal of hangover, which comprises an extract of ginseng fruit, an extract of hornblende, a bottle extract and a mineral concentrate, which are optimized for preventing hangover and / or hangover.

However, the technical problem to be solved by the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.

The inventors of the present invention have found that a composition containing a ginseng fruit extract, a horn bottle, a bottle extract and a mineral concentrate improves the athletic performance deterioration occurring in an alcohol-administered mouse. In addition, the composition showed an effect of increasing the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in liver tissues of mice administered with alcohol. Aspartate aminotransferase (AST) and alkaline phosphatase (ALP ). The results of numerical studies have shown that hepatoprotective effect is reduced by alleviating liver damage caused by acute alcohol ingestion.

Accordingly, the inventors of the present invention have confirmed that a composition containing a ginseng fruit extract, a hinoki extract and a mineral concentrate can be effectively used for the prevention of alcoholic hangover and / or hangover relief based on the above-described experimental results, It was completed.

Hereinafter, the present invention will be described in more detail.

One example of the present invention relates to a pharmaceutical composition for the prevention of alcoholic hangover or a hangover containing an extract of ginseng fruit, a herb extract and a mineral concentrate as an active ingredient.

One example of the present invention,

At least one selected from the group consisting of ginseng fruit extract, fraction of ginseng fruit extract, dried extract of said extract or fraction, and concentrate of said extract or fraction;

At least one selected from the group consisting of Hovenia sinensis extract, fraction of Hovenia sylvia and extract, dried extract of said extract or fraction, and concentrate of said extract or fraction; And

Mineral concentrates containing calcium, magnesium, potassium and zinc;

As an active ingredient, to a pharmaceutical composition for the prevention of an alcoholic hangover and / or a hangover.

Ginseng Berry (Ginseng Berry) is the rare fruit of the 4th year-old ginseng of the youngest period, which is only held for one week in the middle of July. In the past, it has been recognized only as ginseng seed, but it has been found out that it has superior efficacy than ginseng roots through clinical experiments and research results of medical fields such as USA, Japan and Korea. According to research at the University of Einstein in the United States, ginseng fruit inhibits the action of aging genes and activates anti-aging genes, including antioxidants that remove harmful free radicals. In addition, the University of Chicago Medical School has proven the anti-diabetic / anti-obesity effect of the ginseng fruit.

In particular, ginseng fruit containing ginseng core nutrients contains about 30% of ginsenoside, ginsenoside, and the ginsenoside-Re component, which is a specific saponin, is 2 to 8 times larger than ginseng root . Ginseng saponin has been shown to exert its effects on the prevention of aging through improvement of blood flow, and it is known to exert various effects such as wrinkle improvement, skin elasticity and sexual function improvement. In addition, vitamins, minerals, calcium, magnesium, zinc and other minerals are abundant and smooth metabolism, such as ginseng fruit is attracting attention as a modern version.

In the present invention, the ginseng fruit extract includes all the fractions obtained by extracting ginseng fruit extract and ginseng fruit extract.

The ginseng fruit extract, which is one of the active ingredients of the pharmaceutical composition of the present invention, is obtained by dissolving ginseng fruit in water, at least one extraction solvent selected from the group consisting of C1 to C4 linear or branched alcohols, dichloromethane, ethyl acetate, Ginseng fruit extract; And

In order to obtain a better hangover resolution function, at least one fraction solvent selected from the group consisting of hexane, chloroform, ether, dichloromethane, ethyl acetate, butanol, ethanol and water is added to the ginseng fruit extract to obtain a solvent fraction Ginseng fruit fractions, and the like.

The extraction solvent for obtaining the ginseng fruit extract may be at least one selected from the group consisting of water, C1 to C4 linear or branched alcohols, dichloromethane, ethyl acetate, and acetone, preferably water, and C1 For example, from 1: 0.1 to 1:10, 1: 1 to 1:10, 1: 1, 1: 2, 1: 2: 1 to 10:10, 1: 3 to 1:10, 1: 4 to 1:10, 1: 5 to 1:10, 1: 6 to 1:10, 1: 7 to 1:10, 1: 8 To 1:10 or 1: 9 to 1:10, preferably 3: 7.

The extraction solvent may be used in an amount of 1 to 30 times by volume (for example, using 1 to 30 mL of solvent per g of ginseng fruit), 1 to 25 times 1 to 20 times volume volume, 1 to 15 times volume volume, 1 to 10 times volume volume, 1 to 8 times volume volume, 5 to 30 times volume volume, 5 to 25 times volume volume, 5 to 20 times volume Fold, 5- to 15-fold volume, 5- to 10-fold volume, preferably 5- to 8-fold volume.

The extraction time may be 1 to 12 hours, 3 to 12 hours, 5 to 12 hours, 7 to 12 hours, 1 to 10 hours, 3 to 10 hours, 5 to 10 hours, 7 to 10 hours, Preferably 8 hours, but is not limited thereto.

The extraction temperature may be from room temperature to the boiling point of the extraction solvent for effective extraction of the active ingredient, but is not limited thereto.

The extraction method for obtaining the extract of the present invention can be produced according to a known extraction method commonly used in the technical field of the present invention. Specifically, commonly used extraction methods such as cold precipitation method, heat extraction method, ultrasonic extraction method, filtration method, pressure extraction method, reflux extraction method, supercritical extraction method and electric extraction method can be used.

The ginseng fruit fraction is obtained by fractionating a ginseng fruit extract obtained as described above by adding a fraction solvent; For example, after the obtained ginseng fruit extract is suspended in water, at least one fraction solvent selected from the group consisting of hexane, chloroform, ether, methane dichloride, ethyl acetate, and butanol is added to the resulting suspension and fractionated ; And / or a solvent fraction obtained by adding at least one fraction solvent selected from the group consisting of hexane, chloroform, ether, dichloromethane, ethyl acetate, butanol, ethanol, water and the like to the obtained ginseng fruit extract.

More specifically, the ginseng fruit fraction may contain,

5- to 40-fold, 5 to 35-fold, 5-fold to 30-fold, 10- to 40-fold, 10- to 35-fold, or 10-fold to 30-fold the volume of the extract of the obtained ginseng fruit on the basis of the weight (dry weight) Is suspended in 10 to 30 times by volume of water and then fractionated by adding at least one fraction solvent selected from the group consisting of hexane, chloroform, ether, methane dichloride, ethyl acetate, butanol and the like to water, ;

In another embodiment, the ginseng fruit extract may contain 1 to 30 times, 1 to 25 times, 1 to 20 times, 1 to 15 times, 1 to 10 times, 2 to 30 times of the extract solid content (dry weight) , 2 to 25 times, 2 to 20 times, 2 to 15 times, 2 to 10 times, or 2 to 10 times by volume of hexane, chloroform, ether, dichloromethane, ethyl acetate, And water may be added to the reaction mixture and solvent fractionation may be performed.

When two or more kinds of fraction solvents are used, the ginseng fruit fraction may be each of the solvent fractions obtained by performing a solvent fraction using two or more fraction solvents in the order described above.

Further, if necessary, filtration and / or concentration and / or lyophilization methods known in the art can be additionally used after the above extraction and / or fractionation. The dried product or the concentrate of the extract and / or the fraction used in the present invention means dried or concentrated in a manner known per se.

The hinoki tree is also called as the plank tree, 10-17 m high, and the bark is black gray. Winter eyes are covered with two eye scales and have hairs. Leaves are 8 to 15 cm long, ovate, broad ovate or elliptical. There are three coarse veins on the leaf, with serrate on the edge. It is a bloomed white flower bloomed from June to July as a male. The flower runs on a sacrum flower. There are five sepals and petals, and the style divides into three. The fruit that can be obtained from September to October is brownish, 8 mm in diameter, and is shaped like a chicken's claw. Three seeds of fruit each contain one seed. Seeds are dark brown and glossy.

When the fruit is ripened, the thickening becomes thick and rugged. It has a soft scent, it has a sweet taste, and it tastes like a food. It is said that there is an effect of drinking alcohol on the main stem of the river, and the juice is said to release the nausea and stop the nausea. Wood is used as building materials, furniture materials, musical instruments and so on. It is distributed in Korea (south of Gangwon and Yellow Sea), Japan and China.

Oriental raisin tree fructus is a medicinal name and is called as a planet. It is a flat round, with a slightly irregular surface on the back, a relatively flat surface on the abdomen, a diameter of 3 to 5 mm, and a thickness Is about 2 mm. Outer surface is reddish-brown with shiny, oval-shaped seeds on base, with a slightly convex assortment on the end, and one convex longitudinal on the abdomen. It has been used for a long time as a guarantee of a waxy, positive tone,

Holes and bottles applicable to the present invention may be wild or cultivated and may be used in a dry or non-dried state in the production of hull and bottle extracts.

In the present invention, the Hutong and Bottle Extracts include all of the fractions obtained by solvent fractionation of Hutong and Bottle Extracts and Hutong Bottle Extracts.

The Hunt and Bottle Extract, which is one of the active ingredients of the pharmaceutical composition of the present invention, can be obtained by extracting the Hunt and Bottle with one or more extracts selected from the group consisting of water, C1 to C4 linear or branched alcohols, methane dichloride, ethyl acetate, Ginseng fruit extract obtained by extracting with solvent; And

In order to obtain a better hangover resolution function, at least one fraction solvent selected from the group consisting of hexane, chloroform, ether, dichloromethane, ethyl acetate, butanol and water is added to the Houttuynia cordata extract and solvent fraction thereof, And fractions thereof.

The extraction solvent for obtaining the Houttuynia cordata extract may be at least one selected from the group consisting of water, C1 to C4 linear or branched alcohols, methane dichloride, ethyl acetate, and acetone, preferably water, and C1 For example, from 1: 0.1 to 1:10, 1: 1 to 1:10, 1: 1, 1: 2, 1: : 2 to 1:10, 1: 3 to 1:10, 1: 4 to 1:10, 1: 5 to 1:10, 1: 6 to 1:10, 1: 7 to 1:10, or 1: 8 Lt; / RTI > to 1: 10.

The amount of the extraction solvent to be used may be 1 to 30 times by volume (for example, 1 to 30 mL of solvent per 1 g of the cannula and bottle), 1 to 25 times 1 to 20 times, 1 to 15 times, 1 to 10 times, 1 to 5 times, and preferably 8 to 10 times by volume.

The extraction time may be 1 to 12 hours, 1 to 10 hours, 1 to 8 hours, 2 to 12 hours, 2 to 10 hours, 2 to 8 hours, 3 to 12 hours, 3 to 10 hours, 3 to 8 hours, 4 to 12 hours, 4 to 10 hours, 4 to 8 hours, preferably 8 hours or 4 hours, but is not limited thereto.

The extraction temperature may be from room temperature to the boiling point of the extraction solvent for effective extraction of the active ingredient, but is not limited thereto.

The extraction method for obtaining the hull and bottle extract of the present invention can be produced according to a known extraction method commonly used in the technical field of the present invention. Specifically, commonly used extraction methods such as cold precipitation method, heat extraction method, ultrasonic extraction method, filtration method, pressure extraction method, reflux extraction method, supercritical extraction method and electric extraction method can be used.

The hut and the bacterium fraction are obtained by dividing the hound and the bacterium extract obtained as described above by adding a fraction solvent; For example, after the obtained hut and bottle extracts are suspended in water, one or more fraction solvents selected from the group consisting of hexane, chloroform, ether, methane dichloride, ethyl acetate, and butanol are added to the resulting suspension and fractionated ; And / or a solvent fraction obtained by adding at least one fraction solvent selected from the group consisting of hexane, chloroform, ether, dichloromethane, ethyl acetate, butanol, ethanol, water and the like to the obtained starch and bottle extract.

More specifically, the hollow body and the bottle fraction are,

5 to 40 times, 5 to 30 times, 10 to 40 times, 10 to 35 times, or 10 to 30 times the volume of the extract of Huntington and the obtained bottle based on the weight of the solids of the extract (dry weight) Is suspended in water at a volume of 10 to 30 times the volume, and then one or more fraction solvents selected from the group consisting of hexane, chloroform, ether, dichloromethane, ethyl acetate, ethanol and butanol are added to the resulting suspension, Obtained by fractionation;

In another embodiment, the resultant hut and bottle extract may contain 1 to 30 times, 1 to 25 times, 1 to 20 times, 1 to 15 times, 1 to 10 times, 2 to 30 times , 2 to 25 times, 2 to 20 times, 2 to 15 times, 2 to 10 times, or 2 to 10 times by volume of hexane, chloroform, ether, dichloromethane, ethyl acetate, And water may be added to the reaction mixture and solvent fractionation may be performed.

When two or more kinds of fraction solvents are used, the hut and the bottle fraction may be the respective solvent fractions obtained by performing the solvent fraction using two or more fraction solvents in the order described above.

Further, if necessary, filtration and / or concentration and / or lyophilization methods known in the art can be additionally used after the above extraction and / or fractionation. The dried product or the concentrate of the extract and / or the fraction used in the present invention means dried or concentrated in a manner known per se.

The mineral concentrate is a concentrated mineral water with a high concentration of calcium, magnesium, potassium and zinc. Minerals promote various biochemical reactions in the body and are components of enzymes and hormones involved in cell activity. Minerals also act as components of the body, such as bones and teeth. Minerals are the acids of body fluids

Maintains alkali balance.

Calcium is the most abundant minerals in the body, most of which form calcium and phosphate in the form of bones and teeth. Calcium in the plasma regulates physical activity such as nerve stimulation, blood clotting, and muscle contraction.

Magnesium is a component of bone and is a necessary nutrient involved in enzymatic reactions in the body. Magnesium acts to inhibit the excitatory action of neurons.

Potassium is mainly present in body fluid in the cell, maintains osmotic pressure, maintains pH balance, and is involved in physiological actions in the body.

Zinc is found in all somatic cells and is an essential nutrient for protein synthesis and growth. It is involved in the activity of various hormones and enzymes including sex hormones, and is involved in insulin secretion and taste.

The mineral concentrate may include minerals such as calcium, magnesium, potassium, zinc, and the like, and may include calcium, magnesium, and potassium.

The concentration of calcium (Ca) contained in the mineral concentrate may be in the range of 100 to 14,000 ppm, 100 to 13,000 ppm, 100 to 12,000 ppm, 100 to 11,000 ppm, 100 to 10,000 ppm, 200 to 14,000 ppm, 200 to 13,000 ppm, 300,000 to 12,000 ppm, 300 to 11,000 ppm, 300 to 10,000 ppm, 400 to 14,000 ppm, 400 to 13,000 ppm, 400 to 2000 ppm, 200 to 11,000 ppm, 200 to 10,000 ppm, 300 to 14,000 ppm, 300 to 13,000 ppm, 500000 ppm, 500000 ppm, 500000 ppm, 500000 ppm, 500000 ppm, 400000 ppm, 400000 ppm, 400000 ppm, 500000 ppm, . When the amount of calcium is less than the above range, there is a problem that the function of hangover resolving is deteriorated due to osteoporosis, cavity, muscle spasm, nervous irritation, poor growth and decreased coenzyme. , Constipation, dehydration, anorexia, diarrhea problems.

The concentration of magnesium (Mg) contained in the mineral concentrate may be in the range of 100 to 20,000 ppm, 100 to 16,000 ppm, 100 to 12,000 ppm, 100 to 8,000 ppm, 100 to 4,000 ppm, 300 to 20,000 ppm, 300 to 16,000 ppm, 500 to 8000 ppm, 300 to 8000 ppm, 300 to 4,000 ppm, 500 to 20,000 ppm, 500 to 16,000 ppm, 500 to 12,000 ppm, 500 to 8,000 ppm, 500 to 4,000 ppm, preferably 500 to 4,000 ppm have. When magnesium is contained less than the above range, there is a problem that fatigue is easily felt, the freezing point is often lowered, the concentration is poor, and the function of hangover is lowered due to the decrease of coenzyme. Low blood pressure, decreased strength, gait, nausea, and vomiting.

The concentration of potassium (K) contained in the mineral concentrate may be 100 to 18,000 ppm, 100 to 16,000 ppm, 100 to 14,000 ppm, 100 to 12,000 ppm, 100 to 10,000 ppm, 100 to 8,000 ppm, 100 to 6,000 ppm, 300 to 10,000 ppm, 300 to 8,000 ppm, 300 to 6,000 ppm, 300 to 4,000 ppm, 300 to 4,000 ppm, 300 to 18,000 ppm, 300 to 16,000 ppm, 300 to 14,000 ppm, 300 to 12,000 ppm, 500 to 18,000 ppm, 500 to 16,000 ppm, 500 to 14,000 ppm, 500 to 12,000 ppm, 500 to 10,000 ppm, 500 to 8,000 ppm, 500 to 6,000 ppm, 500 to 4,000 ppm, 500 to 2,000 ppm , Preferably 500 to 2,000 ppm. When the amount of potassium is less than the above range, there is a problem that the function of hangover resolution is deteriorated due to reduction of systemic weakness, paralysis, respiratory failure and coenzyme. When potassium is contained in a larger amount than this range, muscle weakness, Nausea, vomiting, diarrhea is a problem.

The concentration of zinc (Zn) contained in the mineral concentrate may be in the range of 100 to 10,000 ppm, 100 to 8,000 ppm, 100 to 6,000 ppm, 100 to 4,000 ppm, 300 to 10,000 ppm, 300 to 8,000 ppm, 300 to 6,000 ppm, 500 to 10,000 ppm, 500 to 8,000 ppm, 500 to 6,000 ppm, 500 to 4,000 ppm, and preferably 500 to 4,000 ppm. When the amount of zinc is less than the above range, there is a problem in that the function of hangover resolution is deteriorated due to growth retardation, decrease in taste, infertility and decrease of coenzyme. In the case where zinc is contained more than the above range, muscle weakness, fatigue, Vomiting, and diarrhea.

The content of the ginseng fruit extract and / or fraction as an active ingredient in the composition according to the present invention can be appropriately controlled depending on the mode and purpose of use, the condition of the patient, the type of symptoms and the severity, and is 0.001 to 99.9% by weight, Preferably 0.1 to 50% by weight, but is not limited thereto.

In addition, the content of the horn extract and / or fraction as an active ingredient in the composition according to the present invention can be appropriately controlled depending on the mode and purpose of use, the condition of the patient, the type of symptom and the severity, and is 0.001 to 99.9 wt. %, Preferably 0.1 to 70% by weight.

In addition, the content of the mineral as an active ingredient in the composition according to the present invention can be appropriately adjusted depending on the mode and purpose of use, the condition of the patient, the type of symptoms and the severity, for example, 250 to 1,000 ppm of calcium; Magnesium 125 to 500 ppm; Potassium 62.5 to 250 ppm; And 100 to 400 ppm of zinc;

When the amount is less than the above range, there is a problem that the function of hangover resolution is deteriorated due to growth retardation, loss of taste, infertility and decrease of coenzyme. When the amount is larger than the above range, muscle weakness, fatigue, nausea, vomiting, diarrhea There is a problem.

The pharmaceutical compositions of the present invention can be administered to mammals, including humans, in a variety of routes. The mode of administration may be any conventionally used route and may be administered, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine or intracerebroventricular injection. The pharmaceutical composition of the present invention can be administered orally or parenterally in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, transdermal preparations, suppositories and sterilized injection solutions Can be used.

The alcoholic hangover-resolving composition of the present invention may further contain pharmaceutically acceptable and physiologically acceptable carriers, excipients and diluents as well as ginseng fruit and / or hinoki extract (extract and / or fraction) .

Examples of carriers, excipients and diluents that can be included in the pharmaceutical composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium Silicates, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, diluents or excipients such as fillers, extenders, binders, humectants, disintegrants, surfactants and the like which are usually used can be used.

Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, and such solid preparations may contain at least one excipient in the ginseng fruit and / or hinoki and bottle extracts or fractions prepared therefrom, , Starch, calcium carbonate, sucrose or lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate talc are also used.

Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like are included in addition to water and liquid paraffin which are commonly used simple diluents .

Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, suppositories, transdermal preparations and the like. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Witepsol, macrogol, Tween 61, cacao paper, laurin, glycerogelatin and the like may be used as a base for suppositories.

 The pharmaceutical composition of the present invention may be administered to humans alone, but may be administered in admixture with a pharmaceutical carrier selected generally in consideration of the mode of administration and standard pharmaceutical practice.

For example, the pharmaceutical composition of the present invention may be in the form of tablets containing starch or lactose, in the form of capsules containing the active ingredient alone or as an excipient, or as an elixir or a suspending agent containing a flavoring or coloring agent Orally, orally or sublingually.

Such liquid preparations may contain suspending agents (e. G., A mixture of PEG-6 esters with a semisynthetic glyceride such as methylcellulose, Witepsol or Apricot kernel oil, or a mixture of PEG-8 and caprylic / Glyceride mixture such as a mixture of glycerides).

Another example of the present invention relates to a food composition for improving alcoholic hangover, comprising a ginseng fruit extract, a hinoki and a bottle extract, and a mineral concentrate.

As described above, the ginseng fruit extract is at least one selected from the group consisting of ginseng fruit extract and ginseng fruit fraction separated from ginseng fruit extract, and the ginseng fruit extract and the ginseng fruit fraction are as described above.

In addition, the Houttuynia cordata extract and the Houttuynia cordata extract are one or more selected from the group consisting of Houttuynia cordata, the Houttuynia cordata extract and the Houttuynia cordata extract, and the Houttuynia cordata extract and the Houttuynia cordata extract fraction are as described above.

The food in the present invention means a natural product or a processed product containing one or more nutrients and is used in a general sense to include all foods, health functional foods, beverages, food additives, and beverage additives. , And the food composition means a combination of materials for producing the food. Examples of the food include various foods, beverages, gum, tea, and functional foods. In addition, in the present invention, the food may contain special nutritional foods (for example, crude oil, infant formula, etc.), meat products, fish products, tofu, ginger, noodles (e.g., , Confectionery (e.g., snacks), other processed foods, beverages, health functional drinks (e.g., hangover free beverages, etc.), and other health supplements. The health functional food, beverage, food additive or beverage additive can be produced by a usual production method.

The content of the ginseng fruit extract or the fraction in the food composition may be appropriately adjusted depending on food use form and purpose, and is preferably 0.00001 to 99.9 wt%, 0.0001 to 99.9 wt%, 0.00001 to 99.0 wt%, 0.00001 to 90.0 wt% 0.00001 to 70.0% by weight, 0.00001 to 60.0% by weight, 0.00001 to 50.0% by weight, 0.0001 to 99.9% by weight, 0.0001 to 99.0% by weight, 0.0001 to 90.0% by weight, 0.0001 to 80.0% by weight, 0.001 to 70.0% by weight, 0.001 to 70.0% by weight, 0.0001 to 60.0% by weight, 0.0001 to 50.0% by weight, 0.001 to 99.9% by weight, 0.001 to 99.0% by weight, 0.001 to 90.0% To 60.0% by weight or 0.001 to 50.0% by weight, for example, 0.001 to 50% by weight.

The content of the hull and bottle extract or fraction in the food composition may be appropriately adjusted depending on food use form and purpose, and is preferably 0.00001 to 99.9 wt%, 0.0001 to 99.9 wt%, 0.00001 to 99.0 wt%, 0.00001 to 90.0 wt% 0.00001 to 70.0% by weight, 0.00001 to 60.0% by weight, 0.00001 to 50.0% by weight, 0.0001 to 99.9% by weight, 0.0001 to 99.0% by weight, 0.0001 to 90.0% by weight, 0.0001 to 80.0% by weight, 0.001 to 70.0% by weight, 0.001 to 70.0% by weight, 0.0001 to 60.0% by weight, 0.0001 to 50.0% by weight, 0.001 to 99.9% by weight, 0.001 to 99.0% by weight, 0.001 to 90.0% To 60.0% by weight or 0.001 to 50.0% by weight, for example, 0.001 to 50% by weight.

In addition, the content of minerals in the composition according to the present invention is in the range of 250 to 1,000 ppm of calcium; Magnesium 125 to 500 ppm; Potassium 62.5 to 250 ppm; And 100 to 400 ppm of zinc;

Another example of the present invention relates to a method for producing ginseng fruit and / or hinoki and a bottle extract having an alcohol metabolism activating action and / or a hangover dissolving action.

In the above manufacturing method,

1) At least one solvent selected from the group consisting of ginseng fruit, hornblende and bottle is added with at least one solvent selected from the group consisting of water, C1 to C4 linear or branched alcohols, dichloromethane, ethyl acetate, acetone, An extraction step for obtaining an extract; And

2) fractionating the extract by adding one or more solutions selected from the group consisting of hexane, chloroform, ether, dichloromethane, ethyl acetate, butanol, water and the like to solvent fractionation to prepare fractions;

. ≪ / RTI >

Wherein the extraction step comprises mixing water and at least one C1 to C4 linear or branched alcohol (e.g., ethanol) in a volume ratio of 1: 9 to 5: 5 (e.g., For example, about 1: 1), or a mixture of C1 to C4 linear or branched alcohols (for example, ethanol).

In addition, the extraction step may be performed once or two or more times, for example, two or three times, and the filtrate obtained in each extraction step may be combined to obtain an extract.

For example, in the extracting step,

1-1) a mixture of water and C1 to C4 linear or branched alcohols (for example, ethanol) at a mixing ratio of 1: 9 to 5: 5 by volume in at least one selected from the group consisting of ginseng fruit, (C1-C4) straight chain or branched alcohol (for example, ethanol), and filtering the mixture to obtain a filtrate; And

1-2) concentrating the filtrate obtained in the step 1-1) to prepare a concentrate of the extract or a dried product of the extract;

. ≪ / RTI >

The extraction can be carried out according to all known methods commonly used in the technical field of the present invention. Examples of the extraction method include cold precipitation, heat extraction, ultrasonic extraction, filtration, pressure extraction, And the like.

In yet another example,

2-1) The extract obtained in the above step 1) is suspended in water in an amount of 5 to 40 times, preferably 10 to 30 times by volume based on the weight of the solids of the extract (dry weight) to prepare a water suspension of the extract step; And

2-2) To a water suspension of the extract obtained in the step 2-1), at least one solvent selected from the group consisting of hexane, chloroform, ether, methane dichloride, ethyl acetate and butanol having the same volume as water is added and mixed Followed by fractionation to obtain a fraction; And

2-3) concentrating and / or drying the fraction obtained in the step 2-2) to prepare a dried concentrate or fraction of the fraction;

. ≪ / RTI >

In yet another example,

2-1 ') To the extract obtained in the above step 1), hexane, chloroform, ether, dichloromethane, dichloromethane, dichloromethane, and the like, which are 1 to 30 times by volume, preferably 5 to 10 times by volume, based on the weight (dry weight) Adding at least one solvent selected from the group consisting of ethyl acetate, butanol, and water to fractionation to obtain fractions; And

2-2) a step of concentrating and / or drying the fraction obtained in the step 2-1 ') to prepare a dried product of a concentrate or a fraction of the fraction;

. ≪ / RTI >

The step of fractionating step 2-1) or 2-1 ') may be carried out in a single step using one solvent, or two or more kinds of solvents may be selected and used sequentially in accordance with the procedure described above to obtain a part dissolved in each solvent And the solvent may be added to the remaining portion to proceed in a multistage manner. The fraction may be carried out once in each fraction solvent, or repeated two or more times, for example, two or three times, Can be combined.

Further, when two or more solvents are used sequentially as the fraction solvent, the concentration and / or drying step of the step 2-2) or 2-2 ') may be performed on the filtrate taken in sequence in the fractionation step .

The term " solids weight " as used herein refers to the weight of the remaining ingredients after removal of solvent components in the extract or fraction.

The present invention relates to a pharmaceutical composition for the prevention of alcoholic hangover or hangover, which comprises ginseng fruit extract, hull and bottle extract, and mineral concentrate as an active ingredient. As described above, the present invention increases the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase , Can be effectively used for bio-alcohol metabolism activation, liver protection and / or hangover resolution by reducing the increase of liver damage indicator enzymes AST and ALP.

FIG. 1 is a diagram showing a metabolic pathway of the human body according to drinking.
FIG. 2 is a graph showing the human metabolic process after drinking. FIG.
FIG. 3 is a graph showing a result of observing changes in respiratory alcohol concentration in each group after drinking according to an embodiment of the present invention. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals
FIG. 4 is a graph showing the results of observing changes in blood alcohol concentration in each group after drinking according to an embodiment of the present invention. FIG. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals
FIG. 5 is a graph showing the results of observing blood acetaldehyde concentration changes in each group after drinking according to an embodiment of the present invention. FIG. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals
FIG. 6 is a graph showing the results of observing changes in blood AST activity in each group after drinking according to an embodiment of the present invention. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals
FIG. 7 is a graph showing the results of observation of changes in ALT activity in each group after drinking according to an embodiment of the present invention. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals
FIG. 8 is a graph showing the results of measuring changes in headache symptoms in each group after drinking according to an embodiment of the present invention. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals
FIG. 9 is a graph showing a result of measuring the change in dizziness symptom of each group after drinking according to an embodiment of the present invention. A: Placebo, B: Ginseng Fruit Extract + Houttuyniae Extract, C: Ginseng Fruit Extract + Houttuyniae Extract + Minerals

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these examples are only for illustrating the present invention, and the scope of the present invention is not limited by these examples.

Production Example 1-1. Production of ginseng fruit extract

10 kg of dried ginseng fruit (purchased from domestic market in Kyungdong market) is cut into 50 ml of an aqueous solution of 70% (v / v) EtOH (5 times by volume of the sample) mixed in a 3: 7 volume ratio of ethanol and water The mixture was immersed in water, refluxed for 5 hours, and then filtered using a filter paper. The extract (filtrate) was concentrated using a concentrator at 50 to 60 under reduced pressure until the solution completely evaporated to obtain 1 kg of ginseng fruit extract.

Production Example 1-2. Manufacture of hinoki and bottle extracts

10 kg of dried hulls and bottles (purchased from domestic Kyungdong market) were sieved and placed in an extraction bottle, and 80 L of an aqueous 10% (v / v) EtOH solution (8 times by volume of the sample weight) mixed with ethanol and water at a volume ratio of 1: The mixture was immersed in water, refluxed for 4 hours, and then filtered using a filter paper. The extract (filtrate) was concentrated using a concentrator at 50 to 60 under reduced pressure until the solution was completely evaporated, to obtain 2 kg of Houttuynia japonica extract.

Production Example 1-3. Production of Simultaneous Extract of Ginseng Fruit and Hovenia

5kg of dried ginseng (purchased from domestic market in Kyungdong market) and 5kg (purchased from domestic market in Kyungdong market) were put into an extraction bottle and 20% (v / v) of ethanol and water were mixed at a volume ratio of 2: 80 L aqueous solution of EtOH (8 vol. Relative to the weight of the sample) was added, and the mixture was refluxed for 4 hours and then filtered using a filter paper. The extract (filtrate) was concentrated using a concentrator at 50 to 60 under reduced pressure until the solution completely evaporated to obtain 1.4 kg of a simultaneous extract of ginseng fruit and hinoki.

Examples. Houttuynia japonica extract, ginseng fruit extract and mineral concentrate mixture

The ginseng fruit extract of Preparation Example 1-1 was mixed with the Houttuyniae L. extract of Preparation Example 1-2 at a ratio of 4: 6, and purified water was added thereto to adjust it to 3brix. The mineral concentrate was adjusted to have calcium of 500 ppm, magnesium of 250 ppm, potassium of 125 ppm, and zinc of 220 ppm. The specific contents are shown in Table 1 below.

COMPARATIVE EXAMPLE 1 < tb >

The ginseng fruit extract of Preparation Example 1-1 was mixed with 4: 6 of the crude extract of Preparation Example 1-2 and then purified water was added thereto to adjust it to 3brix. The specific contents are shown in Table 1 below.

Comparative Example 2. Placebo

Placebo 11.48g of Destrin, 5.6g of caramel color, 0.28g of red ginseng and 0.07g of composite gold extract were added to 140ml of purified water. The specific contents are shown in Table 1 below.

division Raw material name Ingredient content
(weight%) Intake Example
(Bulgogi and Bottle Extract, Ginseng Fruit Extract and Mineral Concentrate) Plant mixed extract (Hut 6: 4 Ginseng fruit) 100 140ml Calcium 500ppm Magnesium 250ppm Potassium 125ppm Zinc 220 ppm Comparative Example 1
(Hinoki and bottle extract) Plant mixed extract (Hut 6: 4 Ginseng fruit) 100% 140ml Comparative Example 2
(Placebo) dextrin 8.20% 140ml Caramel color 4.00% Red ginseng 0.20% Purified water 84.55% Composite Golden Extract 0.05%

Experimental Example  1-1. Selection of subjects

The aim of this study was to clarify the purpose and method of the study and to be voluntary participants. The age was set from 19 to 55 years old. A total of 37 subjects were divided into three groups. Those with history were excluded.

Those who are taking medication or health functional food within 3 months; Those participating in other clinical trials within 2 months before the screening test; Those who are taking other test drugs currently under development in addition to the test drugs used in this study; Patients with hepatic dysfunction such as hepatitis carriers and acute hepatitis; Those taking medication due to cardiovascular disease, renal disease, biliary tract diseases, gastrointestinal diseases, cancer etc .; Those taking antituberculosis agents, nonsteroidal anti-inflammatory analgesics, antibiotics, and antiepileptics that may affect CYP 450; Mentally incapacitated, mentally ill, and those with experience of antipsychotic medication; Those with a history of drug and clinically significant hypersensitivity reactions; A person with a substance abuse history; Subjects with metabolic diseases such as diabetes, hypertension, and hyperlipidemia; Pregnant women, nursing mothers or pregnant women who have plans for pregnancy and lactation during their participation; Persons who are pregnant and who have not accepted adequate contraception (except for women who have undergone sterilization); Or any other reason, that the research director is ineligible for participation in the research.

Grouping was divided into placebo group A (n = 10), group B (n = 10), group B (n = 17) and control group. The physical characteristics of the subjects are shown in Table 2 below.

kidney weight age BMI A (n = 10) 174.25 ± 9.10 75.31 + - 15.43 30.25 + - 5.64 24.58 ± 3.35 B (n = 10) 174.63 + - 5.67 80.75 ± 11.12 32.88 + - 5.25 26.42 + - 2.78 C (n = 17) 175.66 ± 7.29 76.57 ± 13.93 34.13 + - 6.76 24.73 ± 3.31

Experimental Example 1-2. Alcohol intake method

All the Examples and Comparative Examples were orally administered the product on the day before the alcohol consumption 30 minutes before. Then, 3 cups (200 ml, alcohol: 17.75 g) in which alcohol (3.9 g) and beer (110 ml, alcohol) were mixed with shochu (90 ml, alcohol 13.85 g) ). After alcohol consumption, rest was restricted and fasting was performed for 3 hours after alcohol consumption.

Experimental Examples 1-3. How to Blood

All blood samples were collected from the brachial vein using a 5 ml Vaccume tube (1 vacuum tube, 1 tube), Heparin 4 ml Vaccume tube, and 22 gage needle. The total blood sampling volume was 36ml 4 times 9ml once. After the alcohol intake, blood was collected 4 times in total for 1 hour, 2 hours, and 3 hours.

The blood was then centrifuged in a heparin 4ml vaccume tube to prevent clotting, and the blood of the 5ml Vaccume tube was coagulated and centrifuged at 3000 rpm for 15 minutes to separate the supernatant. Lt; / RTI > Blood analysis was commissioned to Samkwang Medical Foundation, a specialized agency.

Experimental Examples 1-4. Statistical analysis

The collected data were analyzed using SPSS (SPSS 21.0 for window, SPSS Inc., Chicago, IL, USA) program and the significance level for statistical significance was set at 5%. The primary and secondary efficacy evaluations confirmed the interaction between biometrics and clinical indicators before and after the administration of the test product by 2way-ANOVA according to the characteristics of each measurement variable. And the mean and standard deviation were calculated.

Experimental Example 2. Observation of respiratory alcohol concentration change

The changes in alcohol concentration were analyzed by using a breathalyzer (Breathlizer, ALTEC, Co., Ltd., Korea) after 1, 2 and 3 hours of alcohol consumption. The results are shown in FIG. 3 and Table 3.

Item group Stable time 1 hours 2 hours 3 hours Group X time F (p) Breath
(%) A 0.000 ± 0.00 0.081 0.03 0.061 0.03 0.044 0.02 3.240 (0.048) B 0.000 ± 0.00 0.067 0.02 0.056 ± 0.01 0.044 0.01 C 0.000 ± 0.00 0.058 ± 0.01 0.047 ± 0.01 0.031 ± 0.01

As shown in FIG. 3 and Table 3, the placebo was shown to be stable (0.000 0.00%), 1 hour (0.081 0.03%), 2 hours (0.061 0.03%) and 3 hours (0.044 0.02% (0.067 ± 0.02%), 2 hours (0.056 ± 0.01%) and 3 hours (0.044 ± 0.01%), respectively. (0.000 ± 0.00%), 1 hour (0.058 ± 0.01%), 2 hours (0.047 ± 0.01%) and 3 hours (0.031 ± 0.01%), respectively. It was confirmed that there was a significant interaction effect between group and repetition. (p = 0.048)

Experimental Example 3. Observation of change in blood alcohol concentration

Before starting the experiment, sample and kit (EnzyChrom ™ Ethanol Assay Kit Cat #: ECET-100 Lot: BG08A18) at room temperature. To dilute the samples to ½, add 5 μL of D.W. to each well of the 96-well plate. Add 5 μl of each sample to each well in order. Duplicate the standard solution and add 10 μl per concentration. Prepare a working reagent. <Well sugar> Assay buffer 80 μl, Enzyme A 1 μl, Enzyme B Mu] l of NAD, 14 [mu] l of MTT. Add 90 μl of Working reagent to each well and incubate at room temperature for 30 minutes. After reacting for 30 minutes, add 100 μl of stop reagent per well and measure absorbance at 565 nm.

[formula]

[Ethanol] = {(ODsample - ODblank) / Slope} Xn (dilution factor) (%)

Item group Stable time 1 hours 2 hours 3 hours Group × period F (p) Alcohol
(mg / dl) A 0.00 ± 0.00 0.08 0.02 0.08 0.02 0.07 ± 0.01 16.370 (< 0.001) B 0.00 ± 0.00 0.08 ± 0.01 0.07 ± 0.01 0.05 ± 0.01 C 0.00 ± 0.00 0.07 ± 0.01 0.06 ± 0.01 0.05 ± 0.01

As shown in FIG. 4 and Table 4, the changes of blood alcohol level at 1 hour, 2 hours, and 3 hours after the stabilization and alcohol consumption were found to be stable (0.00 ± 0.00 mg / dl) (0.00 ± 0.00 mg / dl), 1 hour (0.02 mg / dl) and 2 hours (0.08 ± 0.02 mg / dl) 0.08 ± 0.01 mg / dl), 2 hours (0.07 ± 0.01 mg / dl) and 3 hours (0.05 ± 0.01 mg / dl) (0.05 ± 0.01 mg / dl), 2 hours (0.06 ± 0.01 mg / dl), and 3 hours (0.05 ± 0.01 mg / dl) mg / dl), respectively. It was confirmed that there was a significant interaction effect between group and repetition. (p < 0.001)

Experimental Example 4. Observation of Aldehyde Change in Blood

Prepare sample and kit (Aldehyde Quantification Assay Kit (Colorimetric) - Abcam Cat #: ab112113 Lot: GR284598-7) in advance before starting the experiment. Prepare the 2X Yellow Reaction Mixture as instructed. Add 5 mL of Component B to Component A and mix. Prepare the Aldehyde standard as instructed. (1 ml of Component D into Component C to make 10 mM aldehyde stock solution) - Prepare 1000, 300, 100, 30, 10, 3, 1, 0.3 uM aldehyde stock solution. Add 50 μl of standard, blank, and samples to each well. Add 50 μl of 2X Yellow Reaction Mixture to each well and incubate at room temperature for 30 minutes. After reacting for 30 minutes, the absorbance value is measured at a wavelength of 550 nm.

[formula]

[Aldehyde] = {(ODsample - ODblank) / Slope} Xn (dilution factor) (%)

Item group Stable time 1 hours 2 hours 3 hours Group × period F (p) Aldehyde
(uM) A 531.59 ± 65.25 1073.22 + 247.65 1105.15 + 241.36 1053.23 + - 245.56 1.304 (0.282) B 560.61 + - 142.61 1007.05 ± 205.79 1008.35 + 309.71 961.87 ± 243.72 C 540.87 ± 143.11 994.87 ± 406.09 886.97 + 323.73 862.81 + - 301.46

As shown in FIG. 5 and Table 5, Aldehyde changes in 1 hour, 2 hours, and 3 hours after the stabilization and alcohol ingestion were found to be stable (531.59 ± 65.25uM), 1 hour (1073.22 ± 247.65uM ), 2 hours (1105.15 ± 241.36 uM), and 3 hours (1053.23 ± 245.56 uM), respectively, while the Houttuynia cordata extract was stable (560.61 ± 142.61uM), 1 hour (1007.05 ± 205.79uM) ± 309.71 uM), and 3 hours (961.87 ± 243.72 uM). The extracts of Houttuynia cordata, ginseng fruit and mineral concentrate were stable (540.87 ± 143.11uM), 1 hour (994.87 ± 406.09 uM), 2 hours (886.97 ± 323.73uM) and 3 hours (862.81 ± 301.46 uM), respectively. There was no significant interaction effect among the repeats, but the blood aldehyde tended to decrease.

Experimental Example 4. Measurement of activity of aspartate aminotransferase (AST)

Blood samples of Experimental Example 1-3 were measured according to the manufacturer's recommended test method using an AST measurement kit (Cat No. K753-100, BioVision Inc., CA, USA) to examine the effect on blood AST activity, The absorbance change by deaminated glutamate at 450 nm was used as an index. The amount of AST enzyme in each sample serum was measured in U / L units, and the results are shown in FIG. 6 and Table 6.

Item group Stable time 1 hours 2 hours 3 hours Group × period F (p) AST
(lU / l) A 21.88 ± 7.26 24.00 ± 9.67 23.69 + - 10.94 24.81 + - 10.59 0.316 (0.731) B 22.19 + - 6.55 23.59 6.10 23.88 + - 6.31 24.31 ± 6.37 C 22.06 + - 6.50 21.63 + - 5.70 21.44 + - 4.98 22.06 ± 5.66

As shown in FIG. 6 and Table 6, the AST changes of 1 hour, 2 hours, and 3 hours after the steady state and alcohol consumption were analyzed at rest (21.88 ± 7.26 lU / l) (22.19 ± 6.55 lU / l), 2 hours (23.69 ± 10.94 lU / l) and 3 hours (24.81 ± 10.59 lU / l) 23.59 ± 6.10 lU / l), 2 hours (23.88 ± 6.31 lU / l) and 3 hours (24.31 ± 6.37 lU / l) (22.06 ± 6.50 lU / l), 1 hour (21.63 ± 5.70 lU / l), 2 hours (21.44 ± 4.98 lU / l) and 3 hours (22.06 ± 5.66 lU / l). There was no significant interaction effect between group and repetition, but it tended to decrease.

Experimental Example 5

Headache symptoms and dizziness To confirm the effect of relieving symptoms, subjects were instructed to evaluate the headache and dizziness symptoms after 1 hour, 2 hours, and 3 hours of alcohol consumption by the following criteria.

5: Severe symptoms that affect your life / very severe

4: Somewhat hurt in life / mostly severe

3: There is no hindrance in life, but it is not normal physical condition / Slightly severe

2: There is almost no interference in life / very weak

1: There is no trouble in life / Almost none

6-1. Headache symptoms

The results were as follows: 1 hour (3.40 points), 2 hours (2.30 points), and 3 hours (1.90 points) of the placebo were analyzed for the 1 hour, 2 hour, and 3 hour headache symptoms after alcohol consumption. The ginseng fruit extract was found to be 1 hour (3.10 points), 2 hours (2.50 points) and 3 hours (1.70 points). (2.00 points), 2 hours (1.59 points) and 3 hours (1.18 points) for the extracts of Houttuynia cordata, Ginseng Fruit and Mineral. There was a significant interaction effect between group and repetition. (P < 0.037)

6-2. Symptoms of dizziness

The results were as follows: 1, 2, and 3 hours after alcohol consumption, the results were as follows: 1 hour (3.40 points), 2 hours (2.40 points) and 3 hours (1.70 points) The ginseng fruit extract, ginseng fruit extract and mineral concentrate were collected for 1 hour (2.00 points), 2 hours (1.59 points), 1 hour (3.10 points), 2 hours , And 3 hours (1.18 points). There was a significant interaction effect between group and repetition (p = 0.021).

Sintering

In the first efficacy end point, the composition containing Breathlizer and Alcohol showed a statistical significance, while the second end point efficacy variable, Aldehyde and AST, showed a decreasing tendency, and headache and dizziness And statistical significance.

In addition, the hunger, bottle extract, ginseng fruit extract, and mineral concentrate group showed a tendency that the hangover - related evaluation variables were significantly lower than those of the hunger and bottle extracts and water intake group, which could have a positive effect on hangover - related factors .

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (9)

A pharmaceutical composition for the prevention of an alcoholic hangover or a hangover containing an extract of a ginseng fruit, an extract of a canola and a bottle, and a mineral concentrate as an active ingredient. [Claim 2] The ginseng fruit extract according to claim 1, wherein the ginseng fruit extract is an extract obtained by extracting ginseng fruit with at least one extraction solvent selected from the group consisting of water, C1 to C4 linear or branched alcohols, methane dichloride, ethyl acetate and acetone , The dried product of the extract, and the concentrate of the extract. &Lt; RTI ID = 0.0 &gt; 18. &lt; / RTI &gt; The pharmaceutical composition according to claim 2, wherein the extraction solvent is a mixed solvent in which ethanol is mixed in a volume ratio of 1: 0.1 to 1:10. The pharmaceutical composition according to claim 2, wherein the mixed solvent is used at a volume ratio of 1 to 30 times by volume of the ginseng fruit. [Claim 2] The pharmaceutical composition according to claim 1, wherein the ginseng fruit extract is extracted for 1 to 12 hours to prevent an alcoholic hangover or hangover. The pharmaceutical composition according to claim 1, wherein the mineral concentrate comprises calcium, magnesium, potassium and zinc as minerals. 2. The pharmaceutical composition according to claim 1,
0.1 to 50% by weight of ginseng fruit extract;
0.1 to 70% by weight of hinoki and a bottle extract;
250 to 1,000 ppm calcium;
Magnesium 125 to 500 ppm;
Potassium 62.5 to 250 ppm; And
100 to 400 ppm zinc;
&Lt; / RTI &gt; or a pharmaceutically acceptable salt thereof. A composition for improving alcoholic hangover, comprising a ginseng fruit extract, a hinoki and a bottle extract, and a mineral concentrate. 11. The food composition of claim 10, wherein the food composition is a beverage.

Images