KR20180042691A

KR20180042691A - Novel Proteus mirabilis specific bacteriophage PM2 and antibacterial composition comprising the same

Info

Publication number: KR20180042691A
Application number: KR1020160135180A
Authority: KR
Inventors: 김영주; 연영은; 윤빛나래; 한범구; 김현일; 박철세
Original assignee: 주식회사 옵티팜
Priority date: 2016-10-18
Filing date: 2016-10-18
Publication date: 2018-04-26
Also published as: KR101863588B1

Abstract

The present invention relates to a novel bacteriophage PM2 having an ability to kill Proteus mirabilis specifically; a pharmaceutical composition comprising the bacteriophage for preventing or treating infectious diseases caused by Proteus mirabilis; an antibiotic composition; a feed additive composition; a feedstuff; a disinfectant or a detergent; and a method for preventing or treating infectious diseases caused by Proteus mirabilis, comprising a step of administering the bacteriophage to an animal. The method for preventing or treating infectious diseases caused by Proteus mirabilis by using the bacteriophage PM2 of the present invention has an extremely high specificity for Proteus mirabilis compared with existing chemicals such as antibiotics, and the bacteriophage PM2 infects Proteus mirabilis to propagate by 100 times or more inside the Proteus mirabilis, and thus has an excellent lysis activity and is highly resistant against physicochemical stimuli. In addition, the bacteriophage PM2 does not infect hosts other than bacteria, such as humans, animals, and plants, and thus has the advantages of resolving the problem of antibiotic-resistant bacteria due to abuse of antibiotics, the problem of antibiotics remaining in foods, and the problem of a broad range of hosts. Accordingly, the bacteriophage PM2 of the present invention may be variously utilized in the fields relating to prevention and treatment infectious diseases caused by Proteus mirabilis; antibiotic compositions; feed additive compositions; feedstuffs; disinfectants; or detergents.

Description

[0001] The present invention relates to novel Proteus mirabilis-specific bacteriophage PM2 and an antimicrobial composition comprising the same,

본 발명은 프로테우스 미라빌리스(Proteus mirabilis)에 특이적인 사멸능을 갖는 신규 박테리오파지 PM2, 상기 박테리오파지를 포함하는 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. The present invention relates to a novel bacteriophage PM2 having an exterminating activity specific to Proteus mirabilis , a pharmaceutical composition for preventing or treating infectious diseases caused by the bacteriophage-containing Proteus mirabilis, an antibiotic composition, a feed additive The present invention relates to a method for preventing or treating an infectious disease caused by Proteus mirabilis comprising administering a composition, a feed, a disinfectant or a cleansing agent and the bacteriophage to a subject.

프로테우스 미라빌리스(Proteus mirabilis)는 그람음성 (Gram negative)의 간균, 통성 혐기성 또는 호기성 세균으로 다수의 탄수화물을 발효하고 복잡한 항원구조를 갖는다. 프로테우스 미라빌리스는 다양한 환경에 분포하며 사람과 동물의 호흡기나 피부, 장관계에 감염될 수 있다. 특히 동물의 경우 요로에 감염되어 비뇨계 관련 질병을 일으키기도 하며, 사람의 경우 급성 신우신염을 일으킨다고 보고되고 있다. 급성 신우신염은 신우 신배계와 신간질에 대한 세균성 감염에 따라 발열과 측복통, 세균뇨, 농뇨가 나타나는 것이 특징이며, 주로 일측성으로 나타나기도 한다. 급성 신우신염의 원인균으로는 프로테우스 미라빌리스, 클렙시엘라(Klebsiella), 슈도모나스(Pseudomonas), 엔테로코커스(Enterococcus), 스태필로코커스 에피더미디스(Staphylococcus epidermidis), 스태필로코커스 아우레우스(Staphylococcus aureus) 등이 밝혀져 있으며, 이들 중 특히 프로테우스 미라빌리스는 다른 병원성 세균에 비해 상대적으로 연구가 미진하였다. Proteus Mirabilis is a Gram negative bacterium, tuberous anaerobic or aerobic bacteria that ferment many carbohydrates and have a complex antigenic structure. Proteus mirabilis is distributed in various environments and can be infected with human and animal respiratory, skin, and bowel relationships. In particular, animals are infected with urinary tract and cause urinary-related diseases, and people are reported to cause acute pyelonephritis. Acute pyelonephritis is characterized by fever, sideburn, bacteriuria, and pyuria due to bacterial infections in the pancreas and newborns, and may be unilateral. A causative agent of acute pyelonephritis is Proteus Mira Billy's, keulrep when Ella (Klebsiella), Pseudomonas (Pseudomonas), Enterococcus (Enterococcus), Staphylococcus epidermidis (Staphylococcus epidermidis), Staphylococcus aureus (Staphylococcus aureus ). Among them, Proteus mirabilis was relatively inferior to other pathogenic bacteria.

또한 개나 고양이 같은 반려동물에서도 급성 또는 만성의 방광염이 많이 발생하고 있는데, 이 경우에도 프로테우스 미라빌리스가 원인균인 경우가 많으며, 대장균, 스태필로코커스 아우레우스, 사이트로박터 프렌디(Citrobacter freundii) 등과 복합적으로 감염을 일으키며 병원성을 나타내기도 한다. 이처럼, 프로테우스 미라빌리스는 다양한 동물, 특히 반려동물과 사람에게도 요로 감염 등을 일으켜 급성 또는 만성의 방광염 등 질병을 야기할 수 있으므로 이에 대한 근본적인 세균 제어가 필요하고 최근 다양한 장관계, 피부, 호흡기 감염에 있어 원인세균 또는 복합 감염의 원인이 되고 있어 주목 받고 있다.In addition, acute or chronic cystitis is frequently observed in companion animals such as dogs and cats. In this case, too, Proteus mirabilis is a causative organism, and Escherichia coli, Staphylococcus aureus, Citrobacter freundii ), which may cause pathogenicity. As such, Proteus mirabilis can cause diseases such as acute or chronic cystitis due to urinary tract infections in various animals, especially companion animals and humans. Therefore, fundamental bacterial control is required for this, and in recent years, various types of intestinal diseases, skin and respiratory infections It is becoming a cause of bacterial or multiple infections and is attracting attention.

현재 프로테우스 미라빌리스에 의한 감염을 예방 및 치료하기 위해 항생제를 주로 사용하고 있으나 최근 많은 분야에서 항생제 내성에 대한 문제가 발생되고 있어 이에 대한 원인을 항생제 오남용으로 규명하고 항생제를 충분히 사용하지 못하게 되었다. 이에 따라 산업동물의 배합 사료 내에 성장촉진제로 사용하는 항생제를 금지하기 시작하였고, 유럽연합에서는 2006년부터, 우리나라에서는 2011년 하반기부터 항생제 사용을 규제하기 시작하였다. 또한 항생제가 없는 안전한 먹거리에 대한 소비자의 요구가 증대되고 있어 점차 항생제 사용이 줄어들고 있다. 세균을 제어하는 항생제의 사용이 줄어듦에 따라 세균성 질병이 발생하고 있어 항생제를 사용하지 않고 세균성 질병을 제어하는 방법에 대한 요구가 늘어나고 있다. 이러한 연구 중 하나가 자연계에 존재하는 세균을 죽이는 바이러스인 박테리오파지를 이용하는 방법이다. Currently, antibiotics are mainly used to prevent and treat infections caused by proteus mirabilis. However, in many fields, antibiotic resistance has been a problem. As a result, antibiotics used as growth promoters in industrial animal feeds began to be banned. In the EU, in 2006, Korea began regulating the use of antibiotics in the second half of 2011. Consumer demand for safe food without antibiotics is also increasing, and the use of antibiotics is gradually diminishing. As the use of antibiotics to control bacteria is reduced, bacterial diseases are occurring, increasing the need for methods to control bacterial diseases without the use of antibiotics. One of these studies is the use of bacteriophage, a virus that kills bacteria in nature.

한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 자연 친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.On the other hand, bacteriophage refers to a bacterium-specific virus that infects a specific bacterium to inhibit and inhibit the growth of the infected bacterium. Bacteriophages have the ability to kill bacteria by infecting bacteria, multiplying inside bacterial cells, and destroying the cell walls of the host bacteria when the progeny bacteriophages come out of the bacteria after proliferation. The bacteriophage infection method of bacteriophage is highly specific, so the type of bacteriophage that can infect a specific bacterium is limited to some. That is, certain bacteriophages can infect only a specific category of bacteria, which causes certain bacteriophages to kill only certain bacteria and not other bacteria. Recently, the use of bacteriophage has attracted much attention as a countermeasure against bacterial diseases. Interest in bacteriophages is higher than ever because of the preference of nature-friendly methods. Especially, since 2000, the limit of existing antibiotics has appeared due to the increase of antibiotic resistant bacteria, and bacteriophage is attracting attention as an anti - bacterial agent again with the possibility of development as a substitute for existing antibiotics.

그러나, 반려동물 및 사람까지도 감염시킬 수 있는 프로테우스 미라빌리스에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 프로테우스 미라빌리스에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다. However, research on novel bacteriophages to prevent or treat infectious diseases caused by Proteus mirabilis, which can infect even companion animals and humans, is still lacking. Therefore, there is a need for technology development for bacteriophage having a lytic activity specific to Proteus mirabilis and its application.

이에 본 발명자들은 프로테우스 미라빌리스에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 프로테우스 미라빌리스를 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.Accordingly, the present inventors have isolated bacteriophage having lytic activity specific to Proteus mirabilis and analyzed the morphological and genetic characteristics of the isolated bacteriophage to confirm that the bacteriophage can selectively kill Proteus mirabilis, Thereby completing the invention.

본 발명의 목적은 프로테우스 미라빌리스(Proteus mirabilis)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 PM2를 제공하는 것이다.An object of the present invention is Proteus Mira Billy's (Proteus The present invention provides bacteriophage PM2 comprising the nucleotide sequence of SEQ ID NO: 1, which has an exterminating ability specific to mirabilis .

본 발명의 또 다른 목적은 상기 박테리오파지 PM2를 포함하는, 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공하는 것이다.It is still another object of the present invention to provide a pharmaceutical composition for preventing or treating an infectious disease caused by Proteus mirabilis comprising the bacteriophage PM2.

본 발명의 또 다른 목적은 상기 박테리오파지 PM2를 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.It is still another object of the present invention to provide an antibiotic composition, composition for feed addition, feed, disinfectant or detergent comprising the bacteriophage PM2.

본 발명의 또 다른 목적은 상기 박테리오파지 PM2를 개체에 투여하는 단계를 포함하는, 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.It is still another object of the present invention to provide a method for preventing or treating an infectious disease caused by Proteus mirabilis, which comprises the step of administering the bacteriophage PM2 to a subject.

상기 목적을 달성하기 위하여, 본 발명은 프로테우스 미라빌리스(Proteus mirabilis)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 PM2를 제공한다.In order to attain the above object, the present invention provides a bacteriophage PM2 comprising the nucleotide sequence of SEQ ID NO: 1, which has a killing ability specific to Proteus mirabilis .

또한, 본 발명은 상기 박테리오파지 PM2를 포함하는, 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.The present invention also provides a pharmaceutical composition for preventing or treating an infectious disease caused by Proteus mirabilis comprising the bacteriophage PM2.

또한, 본 발명은 상기 박테리오파지 PM2를 포함하는, 항생용 조성물을 제공한다.In addition, the present invention provides an antibiotic composition comprising the bacteriophage PM2.

또한, 본 발명은 상기 박테리오파지 PM2를 포함하는, 사료 첨가용 조성물을 제공한다.The present invention also provides a composition for feed addition comprising the bacteriophage PM2.

또한, 본 발명은 상기 박테리오파지 PM2를 포함하는, 소독제를 제공한다.The present invention also provides a disinfectant comprising the bacteriophage PM2.

또한, 본 발명은 상기 박테리오파지 PM2를 포함하는, 세척제를 제공한다.The present invention also provides a cleaning agent comprising the bacteriophage PM2.

또한, 본 발명은 상기 박테리오파지 PM2를 개체에 투여하는 단계를 포함하는, 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.In addition, the present invention provides a method for preventing or treating an infectious disease caused by Proteus mirabilis, comprising the step of administering the bacteriophage PM2 to a subject.

본 발명의 박테리오파지 PM2를 이용한 프로테우스 미라빌리스(Proteus mirabilis)에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 프로테우스 미라빌리스에 대한 특이성이 매우 높고, 상기 박테리오파지 PM2는 프로테우스 미라빌리스에 감염하여 프로테우스 미라빌리스 내에서 100배 이상 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 PM2는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 PM2는 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.The method for preventing or treating an infectious disease caused by Proteus mirabilis using the bacteriophage PM2 of the present invention has a very high specificity to Proteus mirabilis as compared with a chemical substance such as existing antibiotics, It has an advantage that it infects Mirabillis and proliferates more than 100 times in the Proteus mirabilis, so that it has excellent lytic activity and is strong against physicochemical stimulation. In addition, the bacteriophage PM2 of the present invention is not infected with any host other than bacteria such as human, animal, and plant, and thus has the advantage of solving problems of antibiotic resistant bacteria caused by abuse of antibiotics, residual antibiotics in food, have. Therefore, the bacteriophage PM2 of the present invention can be variously used in the field of prevention or treatment of infectious diseases caused by Proteus mirabilis, compositions for antibiosis, composition for feed addition, feed, disinfectant, or detergent.

도 1은 박테리오파지 PM2의 프로테우스 미라빌리스에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 PM2의 전체 유전자를 분석한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 PM2의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 PM2의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 PM2의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 PM2의 열 안정성을 확인한 결과를 나타낸 도이다.Brief Description of the Drawings Fig. 1 is a graph showing the results of checking the activity of the bacteria bacterium for protease fermentation of bacteriophage PM2.
Fig. 2 is a diagram showing the result of analyzing the entire gene of bacteriophage PM2.
FIG. 3 is a graph showing the morphological characteristics of the bacteriophage PM2 through an electron microscope.
4 is a diagram showing the results of SDS-PAGE of the protein pattern of bacteriophage PM2.
5 is a graph showing the results of confirming the pH stability of bacteriophage PM2.
6 is a graph showing the result of checking the thermal stability of the bacteriophage PM2.

이하, 본 발명에 대해 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 프로테우스 미라빌리스(Proteus mirabilis)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 PM2를 제공한다.The present invention relates to the use of Proteus The present invention provides bacteriophage PM2 consisting of the nucleotide sequence shown in SEQ ID NO: 1, which has an extinguishing ability specific to mirabilis .

본 발명에서, 용어 “박테리오파지(bacteriophage)”는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.In the present invention, the term " bacteriophage " means a bacterium-specific virus that infects a specific bacterium and inhibits and inhibits the growth of the bacterium, and includes a single or double-stranded DNA or RNA as a genetic material .

본 발명의 박테리오파지 PM2는 프로테우스 미라빌리스에 대해 용균활성이 탁월하다. 상기 박테리오파지 PM2는 150-200 nm의 크기로, 정이십면체의 머리를 가지며 꼬리가 있는 형태인 사이포비리데 (Siphoviridae)에 속함을 확인하였으며, 단백질 패턴 분석 결과 120 kDa, 80 kDa, 50 kDa, 45 kDa, 40 kDa 그리고 20 kDa의 단백질을 포함하고, 전체 염기서열 분석 결과 163,469 bp의 크기를 갖고 GC함량이 32%, 전체 ORFs의 수는 260개임을 확인하였으며 그 전체 염기서열을 서열번호 1로 표시하였다. 또한 상기 박테리오파지 PM2는 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.The bacteriophage PM2 of the present invention has excellent lytic activity against Proteus mirabilis. The bacteriophage PM2 was found to belong to Siphoviridae, which has a size of 150-200 nm and has a head of a regular dodecahedron and has a tail. As a result of protein pattern analysis, 120 kDa, 80 kDa, 50 kDa, 45 kDa, 40 kDa and 20 kDa, and the total nucleotide sequence was 163,469 bp. The GC content and the total ORFs were 32% and 260, respectively. Respectively. The bacteriophage PM2 has excellent stability against heat and pH.

본 발명의 박테리오파지 PM2는 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 PM2는 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.The bacteriophage PM2 of the present invention may include the nucleotide sequence shown in SEQ ID NO: 1 as whole or part of the entire gene. In addition, the bacteriophage PM2 of the present invention may comprise the nucleotide sequence shown in SEQ ID NO: 1 and the functional equivalent of the nucleotide sequence. The functional equivalent means at least 70% or more, preferably 80% or more, more preferably 90% or more, still more preferably 95% or more of the nucleotide sequence shown in SEQ ID NO: 1 as a result of modification or substitution of the nucleotide sequence. Or more and having substantially the same physiological activity as the nucleotide sequence shown in SEQ ID NO: 1.

상기와 같은 프로테우스 미라빌리스 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 PM2를 프로테우스 미라빌리스에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 PM2를 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.The specific antibacterial activity, acid resistance, basic basicity and heat resistance of the bacteriophage PM2 of the present invention can be used for the prophylaxis and treatment of infectious diseases caused by proteus mirabilis and to a composition containing the bacteriophage PM2 as an active ingredient When applied to various products, it is possible to apply various temperature and pH ranges.

본 발명의 박테리오파지 PM2는 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 박테리오파지 PM2로 명명하고 2016년 7월 22일에 한국미생물보존센터에 수탁번호 KFCC11678P로 기탁하였다. The bacteriophage PM2 of the present invention is a bacteriophage isolated from a slaughterhouse, a slaughterhouse, and a farm near the bacteriophage PM2 and deposited on July 22, 2016 with the deposit number KFCC11678P at the Korean Microorganism Conservation Center.

본 발명의 박테리오파지 PM2는 프로테우스 미라빌리스에 특이적인 사멸능을 가지므로, 상기 균들에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다. 본 발명의 박테리오파지 PM2는 프로테우스 미라빌리스에 매우 특이적이므로, 프로테우스 미라빌리스의 감염에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공할 수 있으나, 이에 제한되는 것은 아니다.Since the bacteriophage PM2 of the present invention has a killing activity specific to Proteus mirabilis, it can be used in a pharmaceutical composition for preventing or treating infectious diseases caused by the above-mentioned fungi. Since the bacteriophage PM2 of the present invention is very specific to Proteus mirabilis, a pharmaceutical composition for preventing or treating infectious diseases caused by infection of Proteus mirabilis can be provided, but is not limited thereto.

본 발명에서, 프로테우스 미라빌리스에 의한 감염성 질병은 유행성, 급성 또는 만성으로 발병하는 전염성 질환을 통칭하는 개념으로, 급성 신우신염, 급성 방광염, 만성 방광염, 패혈증 및 폐렴으로 구성된 군으로부터 선택된 1종 이상일 수 있으나, 이에 제한되는 것은 아니다. 프로테우스 미라빌리스는 사람 또는 반려동물의 요로를 통하여 감염되는 것이 일반적이나 피부, 호흡기, 또는 장관계를 통하여 감염될 수도 있다. 본 발명에서 프로테우스 미라빌리스에 의한 감염성 질병은 급성 신우신염, 급성 방광염, 만성 방광염, 패혈증 또는 폐렴으로 인해 발생하는 발열, 통증, 세균뇨, 농뇨 등의 증상을 제한 없이 포함한다.In the present invention, an infectious disease caused by Proteus mirabilis is a concept collectively referred to as a pandemic, acute or chronic infectious disease, and includes at least one selected from the group consisting of acute pyelonephritis, acute cystitis, chronic cystitis, sepsis and pneumonia But is not limited thereto. Proteus mirabilis is commonly transmitted through the urinary tract of a human or companion animal, but may also be transmitted through skin, respiratory, or intestinal relationships. Infectious diseases caused by proteus mirabilis in the present invention include, without limitation, symptoms such as acute pyelonephritis, acute cystitis, chronic cystitis, sepsis or fever due to pneumonia, pain, bacteriuria and pyuria.

본 발명에서 상기 감염성 질병은 클렙시엘라(Klebsiella)속, 슈도모나스(Pseudomonas)속, 엔테로코커스(Enterococcus)속, 스태필로코커스(Staphylococcus)속, 에세리키아(Escherichia)속 및 사이트로박터(Citrobacter)속으로 구성된 군으로부터 선택된 1종 이상의 균주와 프로테우스 미라빌리스의 복합감염에 의한 것일 수 있다.The infectious diseases in the present invention bakteo (Citrobacter) to keulrep when Ella (Klebsiella) genus Pseudomonas (Pseudomonas) genus Enterococcus (Enterococcus) genus, Staphylococcus (Staphylococcus), An Escherichia (Escherichia) in the site and Or a combination infection of one or more strains selected from the group consisting of the above-mentioned strains and Proteus mirabilis.

상기 클렙시엘라속의 균주는 예컨대 Klebsiella pneumoniae , K. ozaenae , K.rhinoscleromatis 등이나 이에 제한되지 않는다. 상기 슈도모나스속의 균주는 예컨대 Pseudomonas aeruginosa , Pseudomonas fluorescens 등이나 이에 제한되지 않는다. 상기 엔테로코커스속의 균주는 Enterococcus faecium , Enterococcus faecalis 등이나 이에 제한되지 않는다. 상기 스태필로코커스속의 균주는 Staphylococcus epidermidis, Staphylococcus aureus 등이나 이에 제한되지 않는다. 상기 대장균속의 균주는 Escherichia coli이다. 상기 사이트로박터속의 균주는 Citrobacter freundii, Citrobacter amalonaticus , Citrobacter diversus 등이나 이에 제한되지 않는다. The Klebsiella spp. Strain may be, for example, Klebsiella pneumoniae , K. ozaenae , K. rhinoscleromatis , and the like. The strain of the genus Pseudomonas is, for example, Pseudomonas aeruginosa , Pseudomonas fluorescens , and the like. The Enterococcus strain is Enterococcus faecium , Enterococcus faecalis And the like. Staphylococcus epidermidis, Staphylococcus aureus , and the like are not limited thereto. The strain in Escherichia coli Escherichia coli . The strains in this site were Citrobacter freundii , Citrobacter amalonaticus , Citrobacter diversus , and the like.

본 발명의 약학적 조성물은 1×10³내지 1×10¹⁰ PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1×10⁶ 내지 1×10⁹ PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, “PFU(plaque forming unit)”는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.The pharmaceutical composition of the present invention contains bacteriophage of 1 × 10 ³ to 1 × 10 ¹⁰ PFU / mL, preferably 1 × 10 ⁶ to 1 × 10 ⁹ PFU / mL of bacteriophage. As used herein, the term " PFU (plaque forming unit) " is a unit that quantifies the formation of a plaque by a bacteriophage.

본 발명의 용어 “예방”이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.The term " prophylactic " of the present invention means any action that inhibits the disease or delay the onset of the disease by administration of the composition.

본 발명의 용어 “치료”란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.The term " treatment " of the present invention means all the acts of improving the symptom of the disease or inhibiting or alleviating and beneficially altering the disease upon administration of the composition.

본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.The pharmaceutical composition of the present invention may further comprise a pharmaceutically acceptable carrier.

본 발명에서 용어, “약학적으로 허용 가능한 담체”란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.As used herein, the term " pharmaceutically acceptable carrier " means a carrier or diluent that does not irritate the organism and does not interfere with the biological activity and properties of the administered compound. Examples of the pharmaceutical carrier which is acceptable for the composition to be formulated into a liquid solution include sterilized and sterile water, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, One or more of these components may be mixed and used. If necessary, other conventional additives such as an antioxidant, a buffer, and a bacteriostatic agent may be added. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to formulate into injectable solutions, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like.

본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 도 있다.The pharmaceutical composition of the present invention can be used as a method of applying or spraying on a diseased site, or may be administered through nasal spray, oral administration or parenteral administration. In the case of parenteral administration, intravenous administration, intraperitoneal administration Administration, intramuscular administration, subcutaneous administration or local administration.

상기 비강 분무의 경우 일정량의 박테리오파지 PM2를 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.In the case of the nasal spray, a certain amount of bacteriophage PM2 can be diluted in water and absorbed into the nasal cavity through a sprayer or spray system. Examples of the nasal spray agent for the nasal spray or the aerosol agent for the respiratory system are mentioned.

상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.The nasal spray or respiratory formulation may further comprise a propellant and / or other additives for dispersing the water-dispersed concentrate or wet powder.

본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감음성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.The appropriate application, spray and dose of the pharmaceutical composition of the present invention may vary depending on factors such as formulation method, administration method, age, body weight, sex, disease symptom level, food, administration time, administration route, Response sensitivities and the like, and usually a skilled physician or veterinarian can easily determine and prescribe dosages effective for the desired treatment.

본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.Examples of formulations for oral administration comprising the pharmaceutical composition of the present invention as an active ingredient include tablets, troches, lozenges, aqueous or oily suspensions, prepared powders or granules, emulsions, hard or soft capsules, syrups or elixirs It can be formulated into a zero. A binder such as lactose, saccharose, sorbitol, mannitol, starch, amylopectin, cellulose or gelatin, an excipient such as dicalcium phosphate, a disintegrating agent such as corn starch or sweet potato starch, a disintegrant such as magnesium stearate , Calcium stearate, sodium stearyl fumarate or polyethylene glycol wax. In the case of a capsule formulation, in addition to the above-mentioned materials, a liquid carrier such as a fatty oil may be further contained.

본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.Examples of the formulations for parenteral administration containing the pharmaceutical composition of the present invention as an active ingredient include injection forms such as subcutaneous injection, intravenous injection or intramuscular injection, aerosol formulations such as a suppository injection method or a respiratory apparatus It can be formulated for spraying. For formulation into injectable formulations, the compositions of the present invention may be formulated as solutions or suspensions in water with stabilizers or buffers in water, and formulated for unitary administration of ampoules or vials. When formulated for spraying, such as an aerosol formulation, a propellant or the like may be formulated with the additive such that the water-dispersed concentrate or wet powder is dispersed.

또한, 본 발명은 상기 박테리오파지 PM2를 포함하는, 항생용 조성물을 제공한다. In addition, the present invention provides an antibiotic composition comprising the bacteriophage PM2.

본 발명에서, 용어 “항생용 조성물”은 약제 형태로 동물에게 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다. In the present invention, the term " antibiotic composition " means a preparation which can be given to an animal in the form of a drug to kill the bacterium, and collectively refers to an antiseptic, a bactericide, an antibiotic and an antibacterial agent.

본 발명의 박테리오파지 PM2는 기존 항생제에 비하여 프로테우스 미라빌리스에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.Since the bacteriophage PM2 of the present invention has a higher specificity to Proteus mirabilis than conventional antibiotics, it does not kill useful bacteria, can kill only specific pathogens, does not induce drug resistance or resistance, Can be used as a new antibiotic with a long life cycling.

축산, 수산업, 반려동물 산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 동물에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞여 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 PM2를 이용할 수 있다.Antibiotics for feed additives used in animal husbandry, fisheries and companion animal industries are used for the prevention of diseases. The administration of antibiotics for prevention is problematic because it increases the possibility of resistant bacteria and antibiotics remaining in animals can be transmitted to humans. If antibiotics are absorbed into the body through meat, they may cause antibiotic resistance and spread the disease. In addition, since there are many types of antibiotics mixed with feed, there is a problem that the probability of occurrence of multidrug-resistant bacteria is increased. Therefore, as a new antibiotic substance for food addition which is more environmentally friendly and solves the problem caused by the use of existing antibiotics, Can be used.

또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.In addition, the present invention can provide a feed comprising the feed composition, and the feed of the present invention can be prepared by separately preparing bacteriophage as a feed additive and mixing the feed into the feed, . The bacteriophage in the feed of the present invention may be in a liquid or dry state, preferably in the form of a dried powder. Drying methods include, but are not limited to, air drying, natural drying, spray drying and freeze drying. The bacteriophage of the present invention may be mixed in powder form in a composition ratio of 0.05 to 10% by weight, preferably 0.1 to 2% by weight of the feed weight. In addition to the bacteriophages of the present invention, the feed may further include conventional additives that can enhance the preservability of the feed.

본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 동물의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.In the composition for feed addition of the present invention, microorganisms other than non-pathogenic microorganisms may be further added. Examples of microorganisms that can be added include lactobacilli such as Bacillus subtilis capable of producing proteolytic enzymes, lipolytic enzymes and glycosyltransferases, lactobacilli having physiological activity and organic resolution at anaerobic conditions such as bovine, ( Lactobacillus sp.), Filamentous fungi such as Aspergillus oryzae , which increases the body weight of the animal and increases the milk yield of the animal and increases digestion and uptake of the feed, and Saccharomyces cerevisiae and yeast such as S. cerevisiae .

본 발명의 박테리오파지 PM2를 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 유지류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.Examples of the feedstuffs containing bacteriophage PM2 of the present invention include cereals, rootstocks, food processing busines, algae, fibers, pharmaceuticals, buses, oils, pastes, But are not limited to, proteins, inorganic materials, fats, oils, fats, oils, monocellular proteins, animal plankton, and remnants.

본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.The composition for feed addition of the present invention may contain a binder, an emulsifying agent, a preservative, etc. added to prevent deterioration of quality. An amino acid, a vitamin, an enzyme, a probiotic, a flavoring agent, A nitrogen compound, a silicate, a buffer, a coloring agent, an extracting agent, and an oligosaccharide. In addition, a feed mixture may be further included.

또한, 본 발명은 박테리오파지 PM2를 포함하는, 음용수 첨가제를 제공한다.The present invention also provides a drinking water additive comprising bacteriophage PM2.

본 발명의 음용수 첨가제는 상기 박테리오파지 PM2 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 프로테우스 미라빌리스의 숫자를 감소시킬 수 있는 효과가 있다.The additive for drinking water of the present invention can be used either by preparing the bacteriophage PM2 or a composition containing the bacteriophage PM2 separately in the form of a drinkable water additive, mixing the mixture with feed or drinking water, or by directly adding it in the production of drinking water. As described above, by mixing and supplying the water to the drinking water, the number of the Proteus mirabilis can be continuously reduced.

본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.In the present invention, the drinking water is not particularly limited, and drinking water commonly used in the art can be used.

프로테우스 미라빌리스에 특이적 사멸능을 갖는 본 발명의 박테리오파지 PM2를 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.The disinfectant containing the bacteriophage PM2 of the present invention having the specific killing ability of Proteus mirabilis can be effectively used as a disinfectant for hospitals and health to prevent hospital infection and can be used as a disinfectant for general living disinfectants, Disinfection of various kinds of growing equipment such as poultry houses, housing buildings such as pens, shaft bodies, water, litter, stairs, transportation vehicles, tableware, and the like.

본 발명의 박테리오파지 PM2는 프로테우스 미라빌리스에 특이적 사멸능을 가지므로, 상기 프로테우스 미라빌리스에 노출되었거나 노출될 가능성이 있는 동물의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.The bacteriophage PM2 of the present invention has a specific killing activity against Proteus mirabilis and thus can be used for washing skin surface or body parts of an animal which is exposed to or exposed to the Proteus mirabilis .

본 발명의 방법은 프로테우스 미라빌리스에 의한 감염성 질병, 예컨대 유행성, 급성 또는 만성으로 발병하는 전염성 질환으로, 급성 신우신염, 급성 방광염, 만성 방광염, 패혈증 또는 폐렴이 발생한 개체에 박테리오파지 PM2를 투여하는 단계를 포함한다. The method of the present invention includes the step of administering bacteriophage PM2 to an infectious disease caused by Proteus mirabilis, for example, an infectious disease caused by an epidemic, acute or chronic disease, an acute pyelonephritis, acute cystitis, chronic cystitis, sepsis or pneumonia .

본 발명에서, 용어 "개체"는 인간을 포함한 동물, 바람직하게는 인간, 가축류 또는 반려동물을 말하며, 가장 바람직하게는 인간, 개, 고양이, 말 또는 새를 말하나, 이에 제한되는 것은 아니다.In the present invention, the term "individual" refers to an animal including a human, preferably a human, a livestock or companion animal, most preferably a human, dog, cat, horse or bird.

상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 인간과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 조류, 어류, 곤충류, 포유류를 모두 포함하는 개념이며, 상기 가축류는 돼지, 소, 닭, 말, 오리 및 개로 구성된 군에서 선택될 수 있으나, 이에 제한되는 것은 아니다.The term "livestock" is a concept that refers to useful animals that are refined and improved by humans to co-live with humans, including birds, fishes, insects, and mammals. The livestock are pigs, , Horse, duck, and dog, but is not limited thereto.

본 발명의 방법에서 상기 박테리오파지 PM2 또는 조성물은 약학적 제제의 형태로 동물에게 투여되거나, 개체의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.In the method of the present invention, the bacteriophage PM2 or composition may be administered to an animal in the form of a pharmaceutical preparation, or mixed with feed or drinking water of an individual, and fed.

본 발명의 방법에서 상기 박테리오파지 PM2 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.In the method of the present invention, the administration route of the bacteriophage PM2 or composition may be administered through various routes of oral or parenteral administration as long as it can reach the target tissues. Specifically, oral administration, rectal administration, topical administration, intravenous, Intravenous, intramuscular, intraarterial, transdermal, intranasal, inhalation, and the like.

본 발명의 방법에 투여되는 상기 박테리오파지 PM2의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다. It is obvious to those skilled in the art that the appropriate total daily dose of the bacteriophage PM2 administered to the method of the present invention can be determined by treatment within the scope of sound medical judgment. The specific therapeutically effective amount for a particular individual will depend upon the type and extent of the response to be achieved, the age, weight, general health, sex and diet of the patient, the time of administration, the route of administration and the fraction of the route of administration, It is preferable to apply differently depending on various factors including drugs used or co-used and similar factors well known in the medical field.

본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.Terms not otherwise defined herein have meanings as commonly used in the art to which the present invention belongs.

이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail with reference to Examples and Preparation Examples. However, the following examples and preparative examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following examples and preparative examples.

실시예Example 1: One: 신규한New 박테리오파지의 분리 및 배양 Isolation and culture of bacteriophage

1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리1.1 Screening of bacteriophages and isolation of single bacteriophages

프로테우스 미라빌리스(Proteus mirabilis)에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 반점 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하였으며, 박테리오파지 분리에 사용된 프로테우스 미라빌리스는 (주)옵티팜에서 야외 시료로부터 분리 동정된 것을 사용하였다. Proteus To investigate and isolate the bacteriophage specific to the mirabilis , a spot analysis was performed. Samples were collected from slaughterhouses, slaughterhouses and farms where bacteriophages were expected to be present, and Proteus mirabilis used for bacteriophage isolation was isolated from outdoor samples in Opti Farm.

구체적으로, 채취한 시료를 균질화 한 후 프로테우스 미라빌리스와 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. Specifically, the collected sample was homogenized and incubated with Proteus mirabilis at 35 DEG C overnight with shaking. The culture solution was centrifuged at 4,000 rpm for 20 minutes, and the supernatant was filtered using a filter having a pore size of 0.45 μm to obtain a sample filtrate.

전배양된 프로테우스 미라빌리스 150 μL를 취해서 멸균된 튜브에 넣고 3-5 mL의 BHI 탑 아가(top agar) [Brain Heart Infusion(Brain infusion solids 12.5 g, Beef heart infusion solids 5.0 g, 프로테오스 펩톤 10.0 g, 글루코오스 2.0 g, 소듐 클로라이드 5.0 g, 디소듐 포스페이트 2.5 g/L) + 0.6% 아가)]를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% BHI 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다. 150 μL of the pre-cultured Proteus Mirabillis was placed in a sterilized tube and 3-5 mL of BHI top agar [Brain Heart Infusion (12.5 g of Brain infusion solids, 5.0 g of Beef heart infusion solids, 2.0 g of glucose, 5.0 g of sodium chloride and 2.5 g / L of disodium phosphate) + 0.6% of agar) were added to the mixture, and the mixture was layered on 2% BHI agar plates previously prepared. After allowing to stand at room temperature for 30 minutes, the sample filtrate was dropped by 10 μL each. Each sample was left at room temperature for 30 minutes and then cultured at 35 ° C. for 24 hours to confirm presence or absence of bacteriophages.

박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(프로테우스 미라빌리스) 배양액 150 μL에 혼합한 후 0.7% BHI 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% BHI 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO₄7H₂O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% BHI 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 BHI 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, BHI 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.45 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 1에 나타내었다.A soft agar overlay method was used to isolate the bacteriophage from the sample which confirmed the existence of the bacteriophage. A sample of which the bacteriophage was confirmed to be present was diluted appropriately with saline, 100 μL of sample dilution of each dilution stage was taken, mixed with 150 μL of the bacterial (Proteus mirabilis) culture, and 3 mL of 0.7% BHI topa was added After mixing well, the mixture was allowed to stand in a 2% BHI agar plate that had been previously prepared, and then incubated at 35 ° C for 24 hours. After incubation, the supernatant was added to 400 μL of SM buffer (NaCl 5.8 g / L; MgSO ₄ 7H ₂ O 2 g / L; 1M Tris-HCl (pH 7.5) And allowed to stand at room temperature for 4 hours. 100 .mu.l of the bacteriophage solution was mixed with 500 .mu.l of 0.6% BHI top agar and bacterial culture, and the mixture was divided into 150-mm-diameter BHI plates and incubated at 35.degree. C. until lysis occurred. After incubation, 15 mL of SM buffer was added to the BHI plate, and the bacteriophage solution was recovered while slowly stirring at room temperature for 4 hours. The supernatant was centrifuged at 4,000 rpm for 20 minutes. The supernatant was collected by filtration through a 0.45 μm filter, The solution was recovered. FIG. 1 shows the result of checking the thus obtained final bacteria bacterium.

도 1에 나타낸 바와 같이, 1-2 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 특이적인 프로테우스 미라빌리스 용균능을 갖는 박테리오파지임을 확인하였다.As shown in FIG. 1, a bacteriophage forming a spore of 1-2 mm in size was identified, and the bacteriophage was found to be a bacteriophage having a specificity for proteus mirabilis.

1.2 박테리오파지의 대량 배양 및 정제1.2 Bulk culture and purification of bacteriophages

상기 실시예 1.1에서 확인한 프로테우스 미라빌리스 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x10⁸PFU/mL로 희석한 후 전배양된 프로테우스 미라빌리스 세균 1.0x10⁹CFU/mL과 혼합하여 MOI (Multiplicity of infection)를 0.01이 되도록 하여 35℃에서 120 rpm으로 9시간 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 PM2(Bacteriophage PM2)"로 명명하고, 2016년 7월 22일 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 수탁번호 KFCC11678P를 부여받았다.In order to mass-culture the bacteriophage specific to Proteus mirabilis identified in Example 1.1, the final bacteriophage culture recovered at 1.1 was diluted to 1.0 x ^{10 8} PFU / mL, and the pre-cultured Proteus mirabilis bacterium was diluted to 1.0 x ^{10 9} CFU / mL, and the cells were incubated at 35 ° C and 120 rpm for 9 hours to obtain MOI (multiplicity of infection) of 0.01. After the culture was completed, the whole culture was centrifuged at 6,000 rpm for 30 minutes to obtain a supernatant, which was then filtered with a 0.2 μm filter to recover the final bacteriophage culture. The isolated bacteriophage was named "Bacteriophage PM2" and deposited with the Korean Culture Center of Microorganisms (Seoul, Korea) on July 22, 2016 and received the accession number KFCC11678P.

실시예Example 2: 박테리오파지 PM2의 전체 유전자 분석 2: Whole gene analysis of bacteriophage PM2

박테리오파지 PM2의 전체 유전자를 분석하기 위해, 박테리오파지 PM2 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL이 되도록 TE 완충액 (Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국). 시퀀싱 결과로 얻은 박테리오파지 PM2 유전자의 유전자 맵을 도 2에 나타내었다.To analyze the whole gene of bacteriophage PM2, 20 mM EDTA, 50 μg / mL proteinase K and 0.5% (w / v) SDS were added to the bacteriophage PM2 culture medium and left at 50 ° C. for 1 hour. The mixture was mixed with an equal amount of phenol-chloroform-isopropyl alcohol (25: 24: 1) and centrifuged at 12,000 rpm for 10 minutes at room temperature to recover the supernatant. The recovered supernatant was mixed with an equal volume of phenol-chloroform-isopropyl alcohol (25: 24: 1) and centrifuged at 12,000 rpm for 10 minutes at room temperature. The supernatant was recovered and 3M sodium acetate was added to the supernatant in a total volume of 10 % (v / v). The mixture was mixed with 2 volumes of cold 95% ethanol, and the mixture was allowed to stand at -20 DEG C for 1 hour. After the reaction was completed, the precipitate was collected by centrifugation at 12,000 rpm for 10 minutes at 0 ° C., washed twice with cold 70% ethanol, and then the ethanol was completely removed to recover the DNA pellet. The recovered pellet was dissolved in TE buffer (Tris-EDTA, pH 8.0) to a final volume of 50 μL, and the DNA concentration was measured. Gene sequencing was performed using PacBioRSII for whole gene analysis (Macrogen, Korea). The gene map of the bacteriophage PM2 gene obtained as a result of sequencing is shown in Fig.

도 2에 나타낸 바와 같이, 박테리오파지 PM2의 전체 유전자의 크기는 163,469 bp이며, GC함량이 32%, 전체 ORFs의 수는 260개임을 확인하였다. 분석한 박테리오파지 PM2의 전체 유전자 서열을 서열번호 1로 나타내었다. As shown in FIG. 2, it was confirmed that the total gene size of bacteriophage PM2 was 163,469 bp, the GC content was 32%, and the total number of ORFs was 260. The entire gene sequence of the analyzed bacteriophage PM2 is shown in SEQ ID NO: 1.

실시예Example 3: 박테리오파지 PM2의 형태학적 특성 3: Morphological characteristics of bacteriophage PM2

박테리오파지 PM2의 형태학적 특성을 알아보기 위해, 그리드를 고정한 뒤 0.01%의 BSA 용액 (Bovine serum albumin) 10 μL를 처리하고 10 초 후 필터 페이퍼로 제거하였다. 준비된 박테리오파지 PM2를 10 μL 취하여 그리드 위에 분주하고 1-2분간 방치 후 필터 페이퍼로 제거하는 과정을 2회 반복한 뒤, 포스포텅스텐산(phosphotungstic acid) 용액 10 μL를 시료를 처리한 그리드 위에 처리하고 5분간 방치 한 후 필터 페이퍼로 제거하는 과정을 2회 반복하여 염색한 다음 투과전자현미경 (Carl Zeiss transmission electron microscope, 80 kV, 120,000~200,000)으로 검경하였으며 그 결과를 도 3에 나타내었다.To determine the morphological characteristics of bacteriophage PM2, 10 μL of 0.01% BSA solution (Bovine serum albumin) was applied after fixing the grid, and after 10 seconds, it was removed with filter paper. 10 μL of the prepared bacteriophage PM2 was dispensed onto the grid, allowed to stand for 1 to 2 minutes, and then removed with a filter paper, and then 10 μL of a phosphotungstic acid solution was treated on the sample-treated grid After leaving for 5 minutes, the filter paper was repeatedly dyed twice, and then examined with a transmission electron microscope (Carl Zeiss transmission electron microscope, 80 kV, 120,000 ~ 200,000). The results are shown in FIG.

도 3에 나타낸 바와 같이, 박테리오파지 PM2은 150-200 nm의 크기로, 정이십면체의 머리를 가지며 꼬리가 있는 형태인 사이포비리데 (Siphoviridae)에 속함을 확인하였다.As shown in Fig. 3, bacteriophage PM2 was found to belong to Siphoviridae, which has a size of 150-200 nm and has a head with a regular dodecahedron and a tail.

실시예Example 4: 박테리오파지 PM2의 단백질 패턴 분석 4: Protein pattern analysis of bacteriophage PM2

박테리오파지 PM2의 단백질 패턴을 분석하기 위해, 1.0x10¹⁰PFU/mL로 준비된 박테리오파지 PM2 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.To analyze the protein pattern of bacteriophage PM2, 40 μL of bacteriophage PM2 prepared to ^1.0 × ^{10 10} PFU / mL was mixed with 10 μL of 5X loading buffer, boiled for 10 minutes, and then subjected to 12.5% SDS-PAGE. The results of SDS-PAGE and protein electrophoresis are shown in FIG.

도 4에 나타낸 바와 같이, 박테리오파지 PM2는 120 kDa, 80 kDa, 50 kDa, 45 kDa 및 20 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.As shown in Fig. 4, bacteriophage PM2 has major proteins of 120 kDa, 80 kDa, 50 kDa, 45 kDa and 20 kDa in size.

실시예Example 5: 박테리오파지 PM2의 다양한 세균에 대한 감염성 조사 5: Investigation of the infectivity of bacteriophage PM2 on various bacteria

박테리오파지 PM2의 다양한 세균에 대한 감염성을 조사하였다. The infectivity of bacteriophage PM2 against various bacteria was investigated.

우선, 박테리오파지 PM2가 야생(양돈 농장)에서 분리한 프로테우스 미라빌리스 균주((주)옵티팜)에 대하여 감수성을 나타내는지 여부를 소프트 아가 오버레이법을 통해 확인한 결과를 표 1에 나타내었다.First, whether or not the bacteriophage PM2 exhibited sensitivity to the proteasum mirabilis strain (Optifarm Co., Ltd.) isolated from the wild (pig farm) was confirmed by the soft agar overlay method, and the results are shown in Table 1.

상기 표 1에 나타낸 바와 같이, 박테리오파지 PM2는 12균주의 프로테우스 미라빌리스에 대한 용균활성을 확인한 결과, 12균주 모두에 대해 감수성이 있는 것으로 나타났으므로 프로테우스 미라빌리스에 대한 용균활성이 탁월함을 확인하였다.As shown in Table 1 above, bacteriophage PM2 was found to be susceptible to all 12 strains as a result of confirming the lytic activity against 12 strains of Proteus mirabilis. As a result, it was confirmed that the lytic activity against Proteus mirabilis was excellent Respectively.

또한, 박테리오파지 PM2가 만성 방광염을 가진 개와 고양이로부터 분리한 프로테우스 미라빌리스 균주((주) 옵티팜)에 대하여 감수성을 나타내는지 여부를 소프트 아가 오버레이법을 통해 확인한 결과를 표 2에 나타내었다.Table 2 shows the result of checking whether the bacteriophage PM2 exhibited sensitivity to the Proteus mirabilis strain (Opti Pharm) isolated from dogs and cats with chronic cystitis by means of soft agar overlay method.

상기 표 2에 나타낸 바와 같이, 박테리오파지 PM2는 임상 균주 8종에 대하여 모두 용균활성을 나타냄을 확인하였으므로 야생 분리주 뿐만 아니라 임상 유래 프로테우스 미라빌리스 균주에 대한 용균활성 또한 탁월함을 확인하였다.As shown in Table 2, it was confirmed that bacteriophage PM2 exhibited lytic activity for all eight clinical strains. Thus, it was confirmed that the lytic activity of not only wild isolates but also clinical isolates of protease mirabilis was excellent.

또한, 박테리오파지 PM2가 다양한 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 3에 나타내었다.In order to confirm whether bacteriophage PM2 exhibits lytic activity against various bacteria, the isolates which were isolated from OptiParm Co., Ltd. and the strains distributed in the microorganism resource center were infected through soft agar overlay method. The results are shown in Table 3.

상기 표 3에 나타낸 바와 같이, 프로테우스 마빌리스 외에도 다른 미생물을 대상으로 감수성 검사를 진행한 결과, 박테리오파지 PM2는 Salmonella Typhimurium, Bacillus cereus, Listeria monocytogenes 등에는 용균활성이 없는 것을 확인하였다. As shown in Table 3, susceptibility testing was conducted on other microorganisms in addition to Proteus marvellis. As a result, bacteriophage PM2 was found to be Salmonella Typhimurium, Bacillus cereus , Listeria monocytogenes And the like.

따라서, 본 발명의 박테리오파지 PM2는 프로테우스 마빌리스에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.Therefore, it was confirmed that the bacteriophage PM2 of the present invention is a bacteriophage exhibiting a lytic activity specifically to Proteus marvellis.

실시예Example 6: 박테리오파지 PM2의 pH 안정성 조사 6: Investigation of pH stability of bacteriophage PM2

박테리오파지 PM2의 pH 안정성을 확인하기 위하여, 다양한 pH 범위 (pH 2.1, 3.0, 4.0, 5.5, 7.4, 8.2, 9.0)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 1 mL로 분주하여 준비하였다. 1.0x10⁷PFU/mL로 준비한 박테리오파지 PM2 배양액 10 μL을 상기 용액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.The number of bacteriophages was measured in various pH ranges (pH 2.1, 3.0, 4.0, 5.5, 7.4, 8.2, 9.0) in order to confirm the pH stability of bacteriophage PM2. Sodium acetate buffer, sodium phosphate buffer, and Tris-HCl were added to each pH-adjusted solution, and the mixture was divided into 1 mL. 10 μL of the bacteriophage PM2 culture prepared to 1.0 × 10 ⁷ PFU / mL was added to the above solution, and left at room temperature for 2 hours. After allowing to stand, each reaction solution was diluted stepwise, and a titer measurement was performed by soft agar overlay method. The result is shown in FIG.

도 5에 나타낸 바와 같이, pH 4-9의 범위에서는 박테리오파지 PM2가 2시간 동안 안정한 것으로 확인되었으며, pH 2에서는 박테리오파지의 수가 3 log, pH 3에서는 1.5 log가 감소됨을 확인하였다.As shown in FIG. 5, it was confirmed that the bacteriophage PM2 was stable for 2 hours in the range of pH 4-9, and it was confirmed that the number of bacteriophages was 3 log in pH 2 and 1.5 log in pH 3.

따라서, 본 발명의 박테리오파지 PM2는 pH 4-9의 범위에서 안정함을 확인하였으므로, 박테리오파지 PM2는 pH 안정성이 우수한 박테리오파지임을 알 수 있다.Therefore, it was confirmed that the bacteriophage PM2 of the present invention is stable in the range of pH 4-9, so that bacteriophage PM2 is a bacteriophage having excellent pH stability.

실시예Example 7: 박테리오파지 PM2의 열 안정성 조사 7: Investigation of thermal stability of bacteriophage PM2

박테리오파지 PM2의 열 안정성을 확인하기 위하여, 다양한 온도 범위 (37℃, 42℃, 50℃, 60℃, 70℃ 그리고 80℃)에서 박테리오파지의 수를 측정하였다. 박테리오파지 PM2 배양액 (1.0x10⁵PFU/mL) 5mL을 멸균된 튜브에 분주한 후 박테리오파지를 첨가하여 30분, 60분, 2시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.The number of bacteriophages was measured in various temperature ranges (37 ° C, 42 ° C, 50 ° C, 60 ° C, 70 ° C and 80 ° C) in order to confirm the thermal stability of bacteriophage PM2. ⁵ mL of bacteriophage PM2 culture (1.0 × 10 ⁵ PFU / mL) was dispensed into sterilized tubes, and bacteriophage was added and left at each temperature for 30 minutes, 60 minutes, and 2 hours. After allowing to stand, each reaction solution was diluted stepwise, and the result of performing a tester measurement by soft agar overlay method is shown in FIG.

도 6에 나타낸 바와 같이, 40-60℃의 범위에서는 30분까지는 안정한 것을 확인하였다. As shown in Fig. 6, it was confirmed that it was stable up to 30 minutes in the range of 40-60 占 폚.

따라서, 본 발명의 박테리오파지 PM2는 내열성이 우수한 박테리오파지임을 알 수 있다.Therefore, it can be seen that the bacteriophage PM2 of the present invention is a bacteriophage having excellent heat resistance.

상기 실험으로부터 박테리오파지 PM2는 프로테우스 미라빌리스에 대한 특이성이 매우 높고, 프로테우스 미라빌리스에 감염하여 프로테우스 미라빌리스 내에서 100배 이상 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 PM2는 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 PM2는 프로테우스 미라빌리스에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.The bacteriophage PM2 is highly specific for Proteus mirabilis and has an advantage of being excellent in lytic activity and strong against physicochemical stimulation by proliferating 100 times or more in Proteus mirabilis by infection with Proteus mirabilis Respectively. In addition, the bacteriophage PM2 of the present invention is not infected with any host other than bacteria such as human, animal, and plant, and thus has the advantage of solving problems of antibiotic resistant bacteria caused by abuse of antibiotics, residual antibiotics in food, have. Therefore, the bacteriophage PM2 of the present invention can be variously used in the field of prevention or treatment of infectious diseases caused by Proteus mirabilis, compositions for antibiosis, composition for feed addition, feed, disinfectant, or detergent.

비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.Although the present invention has been described in terms of the preferred embodiments mentioned above, it is possible to make various modifications and variations without departing from the spirit and scope of the invention. It is also to be understood that the appended claims are intended to cover such modifications and changes as fall within the scope of the invention.

이하 본 발명의 박테리오파지 PM2를 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.Hereinafter, formulation examples of pharmaceutical compositions for preventing or treating infectious diseases including bacteriophage PM2 of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically described.

제제예Formulation example 1: 의약품의 제조 1: Manufacture of medicines

1.1 주사제의 제조1.1 Manufacture of Injection

박테리오파지 PM2 1 ×10⁶ PFU/mLBacteriophage PM2 1 x 10 ⁶ PFU / mL

주사용 멸균 증류수 적량Sterile sterilized water for injection

pH 조절제 적량pH adjuster

통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으 로 제조한다.(2 mL) per 1 ampoule according to the usual injection preparation method. .

1.2 1.2 액제의Liquid 제조 Produce

박테리오파지 PM2 1 ×10⁶ PFU/mLBacteriophage PM2 1 x 10 ⁶ PFU / mL

설탕 20 g20 g of sugar

이성화당 20 g20 g per isomer

레몬향 적량Lemon incense quantity

정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.Purified water was added and the total volume was adjusted to 1,000 mL. The above components are mixed according to a usual method for producing a liquid agent, and then filled in a brown bottle and sterilized to prepare a liquid agent.

1.3 정제의 제조1.3 Manufacture of tablets

박테리오파지 PM2 1 ×10⁶ PFU/mLBacteriophage PM2 1 x 10 ⁶ PFU / mL

옥수수전분 100 mgCorn starch 100 mg

유당 100 mgLactose 100 mg

스테아린산 마그네슘 2 mgMagnesium stearate 2 mg

상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

한국미생물보존센터Korea Microorganism Conservation Center KFCC11678PKFCC11678P 2016072220160722

SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Proteus mirabilis specific bacteriophage PM2 and antibacterial composition comprising the same <130> 1_21 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 163469 <212> DNA <213> bacteriophage PM2 <400> 1 gggttttaac ttcagccata caaacaggaa catctccaat attccacttt ttataaggaa 60 gaccaacttc aatccatggt gtttttgcta aaacattata catgtctata gtgagtctaa 120 gcttccagaa cctatttcta gtaatagata taggtttttc tatatcatcc cattcaccta 180 taaccggtaa atattgccca ccaccatact cttctatttc cattgtatac ggattttccc 240 ataaaaaccc atcaaatgga gcatgtagtc taccatcaac cccttcagtt ggttcaacag 300 tttttattcc taaagaatcg gacaaaagtc tattagataa ccagcctgaa ttgagttcat 360 tggccttatc aattatacac tgacggtgtt ctttatatga tttggtatga gattctaata 420 aaccatcaat aaattcttta aacatatatc ctcctgtttt aatcactggt ctaatatact 480 acattagtag acctgtgtaa actgttttat tctgcccatg gatcggactc agtagtatca 540 tcacggacaa catcttcttc aatcaacgtt ccatggcatc catatttttc tgcatcttct 600 aaagcttctt cgagagtttc tgcttcaact tcgtagactc ttcggccacg aacgtatcca 660 gaaaaattaa taccaatttt aaatgttgcc attttcttct ccgatcttaa tcaaaatttt 720 ggccaaggct tcaacatatg tttttgaagc caaaataaaa ataccattgg tcccttctgt 780 tttagagctc cagaactgtt cccactttac aatagatatt ttatgctttt cgataatatc 840 aaaaatattt ttaggtggtg tagtaaagaa atcaaataca taccaattat atccatcacc 900 ccattcaata ccaccagatg gggtgaaatt acctaagtct tcccagttgt gaaaataaga 960 aagcagttta cgattcattt cttgtttagt cataattagc ctttacaata ttttgcatgt 1020 ctaagtttag cttctaatcc agaacaaata ttgtctttca tatattgttc tatttcttca 1080 gccgtagcac cttcattcac aatcatatca ttaacatcct tggatgtaaa ctttaatttg 1140 tcccacataa caactttttc gccggcatca atcaattttt ctaaacgttt agatgtatct 1200 gggtgcctag gttcattatc taatacccat actctagtat gtggaaatgg aacaaaatca 1260 agacttaaag taccgcctgt tattgcacag gaattaggaa taaacaaaga atctaacggc 1320 ccttcaaaca taaaaacagt tttatttggg tcaactgtat cttgtccgta tatcttagta 1380 gaactctcag aagcttttat tgtcacatat tttgcattag atttctttaa agcccttcct 1440 tggaaacttt ctatctcacc atctttattg aaaataggaa taactaatct atattcttgt 1500 tttggtgtct catatgtgcc aggaacaaca ctgttacata atccttgcca atctgtagta 1560 aaccataacc ttgaccattt gtctttagga atcttcctgg ccttcacgta agatatgata 1620 ggatgtgatt ccggcaattt atccaatcgt tcagaaaaat ttaatttttc tattatcttt 1680 ttaggagcat gtttgggttc gaatttttct accggtttat aaaaaacatt ttgttctttt 1740 ctgcgctcca ttaataaaga aggccaaagt tcaggatgat gggttttaac aaattctgta 1800 aatgggcgac tataatcaca gttaaaacat ttgacccata aacaatccat ttcttggagt 1860 tctataatcc aaaatcttgc tttagtatca gaaacagcag aatcaccaca aataggacac 1920 ctacagttaa ccctaaatgg tgaattgctt gtttttttat acattggttc gaatctgact 1980 atattgtcag caaaatcata atcagctaaa aacatataac ctctatacca aaaaaggagc 2040 catggcccct ttatatcata gtttaattag tagcatcttt tttctttttc tttcctaatt 2100 tattagggcc ttttgaagta atagaaccag aggtttttcc tgatgcaatg ttttctgtac 2160 ttccaccaga atcaccagct atcatttctt caataattgg atgttctaaa aatgattcgt 2220 ctaaattata gtcatccatt atctcataga cttttttaac ccgttcagca taaatttctg 2280 aaccttgctt taaccacctt acatctttat gtaaccgtgt ataagaaggg tcgttcataa 2340 cgaattttat tacatcgcct ttttcattaa taataccttt tttaaaggca tcccattcat 2400 taaaaggtgt ttctaacaat ttaattatac tcatagaata agtccttcta agttaccagc 2460 taatttatca atcttatcac gagtatttaa ttctgcttgg ttaatcattt taccttggac 2520 aacatttaaa tcgggttctt ctttaatagt tgcatctgtt tctacccaac gttgattacc 2580 ctttttaaca attaaattaa atttattcca tttattttta tcgccataac gggacttaat 2640 ttgtttaatt aattgttgtc ccatttgagc cagctcttcg gtttctacaa cacccaacat 2700 aaaatccgct gtagcgggta aacctgctga ttctgcaaca tctgccattt ccatgtctga 2760 agcagaccat gcttgtcttc cggtttgagc agctgtccat aatacggttt gggtttcaat 2820 agcaagtcca cgtaattctt cagcaattgc ttttattaac gtataactgt tttctgtaaa 2880 ttttagacgt gtactgccac aaatacctaa gtagtcaata ataataatat ctggaataaa 2940 cccatctttt aatttaagtt catttaaaag agcccggaaa gtattggcat tggcaccacc 3000 tgtaggatat tgcttaaact tcaatcttcc tggggttttt ccaccggaac cttttttaag 3060 gcgttccatt ttggccttaa attccgtata agtaatatta ttattatcaa tgtcatctaa 3120 agatacatcc aataaattgg catcaatacg tttagcacac acatgttcgg ccatttccat 3180 actgatatat aaaacgttat atccagtttg aagataatca gctgctaatg aacatagacc 3240 aagtgattta ccaacgttaa cacctgccat taaaatgtta agtgtacctt tttcagcacc 3300 gccttttgtt attctattaa gaatagataa tttaaaaggg accttattag cttttgtctg 3360 atataataac catcgttttt cataatcgtc aaaataatca tgtccaatat cagaatcaaa 3420 acatatggac aacgcttctt gaagaatctc tgggataatt cctttgtcag gaagtttttt 3480 atcacgtttt gactcgtcta aagaggcatt tgtttgtatt tctatacttt tagacatagc 3540 attatacaaa gcaatgtctt gtacatattt ttctgttgat ttaataagcc aatcaaaatc 3600 ttcaggtgta tttttcattt tccctaaaaa ttcttttgcg gctttaaatt gagaatctcc 3660 gagtgaacta ttttccaaag caatatctaa agctgttaca gttggaacgg atttaaattc 3720 ttctacatgt tttttgattg tattaaaaat agttttagaa gagccatcaa aatattcttg 3780 ttttaaatat ggccaaactt taacaaaata atctttatta taaattagct gagataagat 3840 tacgttaacc atcagtgtcc cttaaatata tcaaaaatac ttttggattt aactttagta 3900 ttttcaattt gtgatttaat acatttttca atatgtggtt ctaaaatatc ttttggcaat 3960 tcagaaagag tagaataatc atattctact tttccgtttt taatatccat agaatgaata 4020 tacactaaat gaggagtgtt gtcaattaaa atcattattt cttgaataat atctttcatc 4080 gattctttga caatgtttaa tgacttttca tatatttcct ggtcattccc tatattgtca 4140 agaatcttaa attcttcatc aaagttttgc ataaatataa tttccacagt cccaaattcg 4200 acgaagcccg ttattataac agttttcaac ttctgttaat ttaggattaa aatctaaaag 4260 tttatctttc aatttatgtt tcataaacga agacctatga taaagcttac cttttacaat 4320 ataatagtag cacggttctg atgtaccgat gtattttaat cctaatttat tatatacatt 4380 tccttgtgac catcttctat ttgcataaga aatatatgtt aaccctttta ataatttaga 4440 agcacctcca acaactgtat atccagcttt agaacataat ctaagtaatt ctagatcata 4500 ttctttatta tatctggatt taccaagaac agctacttgg acaagttcat cattatagaa 4560 taacccttta taaattgaac ctggacattt accttgtagg tggttttctt ctatgaaatt 4620 attagcaatc tttttatcaa ttttttttaa tgaacatttt ctagcgtata ttcttttaga 4680 taacccaagt ttatttttaa taacggattt ccatatttct tttttaacag ggtcattcca 4740 ttcattctca aatatatgaa gaagatttat ccctttagat tcacaaagtt ccgttttatt 4800 gagatggtat ctatacaatc ttttatcatc ttctttagaa ttagaagagt gccaatatac 4860 cccattaaat tcgatagcca aggagtgact aggaacatag atatctaatt catatggtaa 4920 tataatctgt ttggtgtttt gttcacagga cacacctagc gaacaaatat aatcatatac 4980 ttcttgttct aatccagatt taccagacat tgatttaata ggatatccat gtttttccat 5040 gaacttaaat gcagaagaat gagagtttaa agataaccca aaatgctttg caacgtcttc 5100 ccaagtttta tttgatagat cttccattat atctggattt tttatgtcat ccaaattctt 5160 ataattatat tgtaatggat gttcaccaag ttgatatttt tttcctcccc attttctttc 5220 cgttccgtat ttgtccatac aagttcttct agttttattt tgggttttta cagatttaat 5280 agagcactta ttagaacaaa cttctaataa tttatttctg tatacaataa cgggtttgcc 5340 acaatgacat ttaggcacat cttctatttt agtaataccg ttttcaagaa acacaataac 5400 ctggggcaat gaagccccag gaaatgattt aattatttct tgaaataaaa cagtattatg 5460 tttttctaac cattgtaaat ttcgtttcgg gactaattta ccattagaat aacataaagt 5520 ttttatttca tttatcataa ttcttccata gattccaatt catccatagt agaagcaaca 5580 gaactatcag agaaaacatg atcttctact tcaagattca ttaactcttt tacttcttgt 5640 tctactgatt catcattaac catttgccca agtttatatc ggttttcaat agcttcacgg 5700 aatggagcat gtttcaataa aggtccccag aaagcaacac atcttgtgtc tttagctcgc 5760 caattctttt cttcaggaac catttcaccg gtttctttat ttaaaaatgc ttgagtatac 5820 cagccgtttt taggtttaac aacaaatcct aattctaaac ccatatcaag taagccagaa 5880 taagggtcaa taccaccatc aaatgtaacg tcaataaaga atttagattt ttcttttact 5940 gtacgagatt tttctacatt taaaacaaat tgataacctt gaagatcggt accatcttta 6000 atttgacgac gaccaataat atacacgtta tctgcagaat acatcacccc ggtattatgt 6060 gtaactacgc cattttctaa tacataatgt tctacatctt ttacggataa atcgtatact 6120 tcttttttac ctacgtgatt aatattttta attttcatac atcgccttgt tcttgataat 6180 agcttgtttc aatataataa tactggtttt ggttacgcat aatctcattc gcaactcgtt 6240 cgccgtattc ttcgaccatt tgtacataat ctaaacgtct tagatagaac tcatttaaga 6300 acgctttaat tatgtgaatt tgtgttttat ttgtcatttt gcaccttaac tttacagtta 6360 tcaaaatgcc aacgtctcat attaccagga accccggatt ttccacaatg tggacatgat 6420 atagtttcta tcatacctaa tttagcttta agtgttagag gattcatata tcctaaagct 6480 ttatattcat cgaccttaga tttgtcaaca aacacagttg gataccgctc tttgtcttca 6540 tgtactaacg taaccagacc ctttttaaac tttgatgtct tggcaagctt ggctttatgc 6600 tcttcagttt tcttaacacc ctttctggat ttagacattt tgagtttagt ctcaatcgac 6660 gctttcttac cagtattagc gccaatataa gtcccatcta aaactttagg atgattggta 6720 ggtagcctaa ctcgttttcc tgtaatagtg tgcatgtaag tcccactgtt tgcatcgcta 6780 aagctagata gtctcgcgag actcaaatta aaatattctg ggctggcaac aacatcatgt 6840 gcaatgtgat actcacgttc tttaacaaga atatccgggc cttcgtataa aatatgacat 6900 tcgatgtctt cacttttaac aagagatcta taacctggcc atctagagct accaaaatat 6960 tgtttacctg ttcgagtgtc aaagatttta taatcatcta ctctggcatt agatttgctc 7020 ccaatataat aaaacggtgg ttcgtttcgt tcaattctag atttaaaaat aattttatat 7080 acaatgtcca tactaggctc cgattcaata actaatagta tttatatcgg agcttagtcg 7140 ttatgtactc agccgatact tatcgaatcg cacaatccat accaactaat aaatctttgg 7200 cttcaaccca cgttggaata tcttttacca ttaccaagaa tttatgtgta tctgaaacag 7260 ttactttata tccatcttca aactcgattt ctatacattc aggggttcct tcagccaaag 7320 tttcggggtc ccaaatataa gtaacttcat tatcaccaac taaagtttta actctatcac 7380 ctggtttaat atcttctaca tttttagtag aaccatcagc cattttaatc ttagttccag 7440 caacaacaca accaccagtc ataacggttt tactgaacat ttcaattgtc tcaatggtat 7500 gattaatacc tacacacgga atatccttta aagtaaaata tggagtagcc atacggaaca 7560 atgattttaa ctgcttagcc cgtgtcatat cagcgacaga tttttcattt aaagcatctt 7620 caacttcttt cttagaagct aagttaccaa tagagtcaat aaagactata actttttcac 7680 ctcgttcgat ggcttctaat tgattaatca tatcaatttt aagttcttct acgtttttaa 7740 ctggagtatg aacaactctg tctgggtcaa cacccataga acgtaaatat gcacttgtga 7800 taccaaattc tgaatcgtaa aataaacaaa ttgcatcagg atatgcattc atatatgcgg 7860 ctactaatgt aagtcccata ttagatttaa agtgtttact tggaccagct aaaatagtaa 7920 taccagattg aaggccacca ttaataatac cagataatgc aatattcaaa gtaggaatct 7980 tagttctaac aacagatttc tcattgaaga atttagattc gctaagaaca gaagtcattt 8040 tattagtaga agctttcatt aaacgttttt ttaagtctga cattttttat cctttaaaaa 8100 tgacaaacat aatattttac tcaaatcact aattagattt cccaaatagg gcctttaaca 8160 ataatatctt catatgacgg taatgcataa atacattgta cattacattt aaaatatata 8220 aattccgcta aacccggatg aaacaccttt tcaggatttt cttcatatat aatattaggt 8280 ttagccttta atgcgtggta atattctgat ttatttaatt ttaataattc gcagtcagga 8340 tatttttctt tatcccaaga atcattaggg tctgttataa ctaatttgag atcatacatt 8400 ttacatgtat gatatacata atcgaaatca tagcacttgt ctgatattct aaatggaaaa 8460 aatattgtat tcttccaatc aaagtctata caggattgtt gcataaactt ctcaggaaca 8520 ccaggagtaa ttacttcttg tgtaacaatg attttatcag acaaagctcc atgagacact 8580 agaacatctt tctggcactt attaagaact gttgtgtaaa tacttctatt tacagaatca 8640 acatcttctt gaataaattc atcaatatat tctcttgggt gtttagggtc ttttgtgata 8700 ttaaaattaa aaaagaccgg aaacgctcct ttatatcctg ttatatcgct tactacggca 8760 tcacaattat aaaaattagc taaagaatct accataaatg tattgtattc ccagaatgtt 8820 tttctggatt tataagcatt ttcttgataa acagcttctt caaaaataat atcaggaaaa 8880 tattcttgta attcctctga atcttcacat tgtaaagaat gtggaataac aataacatca 8940 cctttttggt gccgatttaa atgtaattga agatttccgt cttttaacag ggaatatttc 9000 cctgttttat aagacctcat agaatacatt ggtacaatga gattcataat aatccttata 9060 gaaaagattc tacatatttt atatcgcgtt caaatacatg agcagaaacc atagaatggg 9120 tgtaatgacc taaagaaaca ccacattctt ttgcaatgta ttccattaat ttaccttgta 9180 aataaatatc aagttgtaat actactgcac aattctgtga acgcatatgg gtgtgagtat 9240 ataatttacc attacgaata taatatgtta tagaatctgt acaagggtat tctaatgatt 9300 catctgaatc taataaagcc tggtcttgtt cttgaagaat ttggaatacc actcttcgtg 9360 agttaggttt ttctttaagt tctttaagca aggcaggtaa ttgggccaaa attctaggac 9420 cataaaaagt gttgaagtta gcaggtaaaa catcactttt tggcttacta ataaatttag 9480 ctacatttgg atattcttta aatgcttctt ctgcatcagt tccaccagaa atcataaatt 9540 gccaaaaatc ttcagcgtat ttgtaatcaa tacggtttat taaaaggtct tcaaatttat 9600 atgtagaagg gtccattact cgaaaacaaa gtgagccaat ttctcggcat tcgccaattc 9660 tggactcagt aataaagtca tattcagaaa taactaaatc attaacagtc ttaaaagcgt 9720 cttcaaatgt ttgtttaaca atcataaaag tccttgtaat tttttagaat attgcattaa 9780 aaatataatt aatggctgtg cttctggagg agtatttaat aatttctttt cttctacttg 9840 tccattatat atcggtaaat gattagcttt tttggtttgt ccaattttaa ttgctaattt 9900 attccgttta ttaaaaagat caatcatttg tttatctatt tcttcgatag attttctatc 9960 tttttctaaa gattctttat tattcagatc tttaatccag tctttagcca ttgaagaaga 10020 aatattttta attaattctt taggaattgg cggaatatca attccaggat aatccttatt 10080 taagaatatt tttggtgttc ttggtggcca aaatgattca catttcatga ggaacctcaa 10140 tttttataag aataaagtaa taatattatc attaaattta attagcatta tttacctaat 10200 attttaccgg aagggccatc atacaaagag gcttttataa taaaaccttt tagatcgtgg 10260 ttgtattttt tgaatttaga ggttttatct gtaaatgccc tggttgaaat atttctactt 10320 aaagcaggca caagcctgct caataaagtt ttcttcatat atatctccag ttgtaaccgt 10380 atgccttaga accagatttt atggctctag taatattaga agaccttggt ttatttaaat 10440 acattgcagc cctaaattta gaagaaaata ttatgctttc tgaatcattc caagctacaa 10500 caggtctatt atcaaaatga ttgtggtttt ccgccttctt tttatcagac atctttttaa 10560 ttgtttcttt agaatgtttt tttccttcaa atccggcgac atttgataat tttctatttt 10620 tactcattaa taatttagac ttttctgtat gctttttacc tttccaaggt gatttaagaa 10680 ttaatgtttt tcgtatctta gatttagttt cttcagaaat aggaacccct ttaagaggac 10740 tcctattttt agaaaaatat ttttttaaag acctacttat tttaatcttt gtatcatctg 10800 atattgccgc cccatatcca cctaatttta gattgtatga agatctatct aacacaacgt 10860 catttgtcac taattcagat tcttttaaat acgagtcttc ttctgtgtca caaaagaaca 10920 aaatttctct ataaaaatta tctttaccat atttagctat tgcggctgat aaggcttgtc 10980 cagaaccaag atatccatca tttaaatttg atgtactatg tttcccaata taatacatcc 11040 catttaattt gcatgtcgtt ttatatacta tattaaatct ctgggtatct ttcttcatca 11100 tcggcaccgt ctaaaacctt gatttctatt tcatcaggtt tacgatcatt tttagataat 11160 tgacgtttat aataccgttc acaatattta catgtcgtac cacagatttc attagcacaa 11220 tcaaaatcag gatgtttaaa ccaacgttta tttaaaaatc catctaataa agaagtttct 11280 aaatatactt ggtgttgatg gtctaattct gattgaccat tataaattgt ttctaatggt 11340 ttccagagct ctaataaatt accttcaaac ttttcagatg cataagcttc tagaacttta 11400 acaatatatt ctgttgttcc agtacggcct gatactttaa actgagaaat accaatagaa 11460 cggtatagct caagatcttg tggacgaata aatcttgtac gaagccaatt aaatgggtca 11520 gtatcacgag ctttaataca gtgttgcatt ggatatccat tcaaagattt agcatcttct 11580 gctgttatat ctgtactatg aaaaatataa catgaatcac ggtaagagca atgagttgta 11640 tatcctttac cggcatttga acagaattcg tttacaagca attcaaatat gattccattc 11700 ttattgcaaa actccgcggc tcgttttaaa aatgaaacac ttcggttttt atgaatacca 11760 caacaaactt tcttaatatt atattggtca tgaagatatt tgatttgtgt tacagcatca 11820 acatgaagaa tagtagaaac ttcaaattga atttctttat taacttcacg aataatttcc 11880 ataataattg gattagcaac cgttacacga taaacaccta tactccatag atattgaaca 11940 taatcttgga tggctttctt tttccattcc tgtaactctc ttttagagcc agggttaata 12000 gtgttcagtg tgtaattgaa acatattcct aagtcattgc aacgttgtac gtatgtttct 12060 agttgttcat tttttacatc aggtaatcta aaatcaggtc tggccgcagc aaaagccata 12120 tctcgtgtgc taccatacac ttcattaata atactattag ggtatttctt gtttaattca 12180 acaattttat caagaagagt taaatcaaaa ttagtcccaa ctttaaatgt atttttcatt 12240 ttgttcctta tttacaaata aaggcctttc ggcctttaat tattttttta attgtgctgt 12300 gacttcatct aattttgtag acatatcttt aaaagtaatg tcatttcctt gcaggcttga 12360 cacaatagtt gacactaaaa caacaaagga taataaaaca cctacacaaa aaacaaaaac 12420 tgaacttgcg gcaccaataa gaaggccaag aactaaattt ttaaaatatt ttaatacttt 12480 catttattgt cctaatttag aattaatata gttaataaca gaatcgtacg gagctgcatc 12540 taaaacatta tttttagaat catgctctac cagtttaaat gtttggatgt tcatattatc 12600 ataaaataaa tcatagaccg aaataatgtc attgaattca tctttggata atttgattaa 12660 atcatcttca aagtcttcgc ctaatctatt acgagttaga cctacaacaa gacattttga 12720 tcttaattta attaaatctt ttacatagtt attaaaagat tcttgatttt ctttaataat 12780 aaatgatttg ttatgatgtt tacgatagat ataataaacc atattactta aaaagcaacg 12840 atccaataca tattttttag tagggtctaa gtgttcaagt aaagtttcaa aaatagctac 12900 ttcgcttctt gtgactatag taaacaatcc ttcagaagtc tttttaggga attctattaa 12960 agtgaaccct tcattttcta ctaaatgttg tattaatgta gttttacctg aattatcagg 13020 tccttcaata gcaacaatat tcattttatc tccggaacgt atggtttgta attagataag 13080 ccagatttag caagcttttt gaatgtacca gggtccatag ccttatcatc tacaattaaa 13140 tcgtaaaacg gcttatgagt taatagattg tgatatttta atccaataga ttctaaatta 13200 gaaaccagtg atggaacaat ttctgtagca attttaccag gacctactga agtcatacca 13260 cgagcggtgt ataatgttat agtatgacct tcatcataaa ggtcattaat aatttttacc 13320 atttctgggt ctggtttaaa attttcataa tccctattgg tattccatag ggttattgta 13380 ttatctatgt caaaaaataa attcattgca ctttagtcca ctgtttaaat aattctaaac 13440 ttccggatgg tttatatttt acatcagttt ctaaatcatg caaaatccat ttttcagggc 13500 atttggtaat aatagaaagt gtaacaccat tttttaattc aggaacctgt tcacctgatt 13560 ttaaagttct tgatttagga atatttttta ataaaaggga aagtttgtat aagccgttat 13620 aatatgcacc caaagctttt aaagggttat ttttaaaata tccggctaaa gccatccaaa 13680 taacagcaat ccataatttg tgtttaaatg tacacatagg aatgtcatct aaaggcataa 13740 ttggtttaac atcaacaaat actttctttc caacaagaca caatccaccc catagtgggt 13800 cggaattaaa ttcgtcgtat ccatcaatag aatataaaac tttggcttcg tcgtaaatag 13860 ccggaccttt tacagaattt ccgaaatatc cacgtgggtc aattatttta atatcaccct 13920 tatcactaaa caaaatatta ctgtagtgtg ggtcaccatg gataaattga tatggttctt 13980 ttttatcaga taaaatttcc aaggcctgtt ttagtaattc ttcagggtct gaaactttaa 14040 catcattgac atgagttaca ccatttggtg caaatccttt aattaaaggc tcaatagatt 14100 cgtttctaat taaaacttta tcaagaactt cttttttaac atcagaatac caggtttcat 14160 cttcagggat aattgggtca ccactaatag attttaatgc agatataact ttatatacca 14220 taagaatttg gctttcttta gtcattaact tataggcttc agccattgtt aagccgtaaa 14280 tacgttccat tttaataaat tcattaggct taaaatcaaa aatagtagga atgaatttag 14340 aatctacatt agagtaccaa ttcatttctt tttgttgcat ttgtttgccg aattcgttgg 14400 ttgggatttt gaatacaact tcaccatcaa attctaattt attaaagtcc cggtttattt 14460 ctgattcttc atgggcttta gctaattttt ctttatcccc aatatcaata accttaggta 14520 atttaaattc ttccatttta aatggcatat tattgatatt atcagctaaa tcttctccat 14580 aaggcccttt aaatccttcc caatttttaa tttgatacat tcctactacg ccaccacctg 14640 taccaacttc attaaattta ttatcgacaa attcaaatcg gcaatcggtt ccaaatgtgt 14700 agcaataatt atgaccccaa tcaacaatat gattttctgg gataatatca caccagttaa 14760 aaaccacatt atggccaata atatcatctt taatagaatc tatagcatgg gcacttccaa 14820 aagaaacatc cacatttcta atagtaatat ctggaagacc cattgtttta atataacctt 14880 taacaagagt gttatatttg ctatggataa ctaagataat ctcatccgat tgaggtgaat 14940 ataaatcaac caggtgtttt aagactgtgt gttgtttata gttaaccata actttaggaa 15000 tttcgcttgt tataggatat aaacgcgaac ctaaacccga acttaatatg acaactttct 15060 tcatttattt ttctcgcaaa ttttctttaa tgtaggaaca tcgtatttaa caacctgaga 15120 ataatcacct gttaaactag cattttgttg cataacacgg tatgtgataa cagctcgttg 15180 ataacaattg agctcaactt ttttaggttg ttccatagga ggaagatttc tgtcttttgc 15240 taattgagca tcaactcgtg ctgaagcttc tgcgatttca gcacgaacac gtaatctgtc 15300 tgcttctctt ttggcatcaa gttgacgttc taattcagct cttgattgat attgtggatt 15360 tttattaaaa taagcgattc cattagatgt tgatgctaac tgcccagatt gttgcattct 15420 agcttcacgt ttagctttgt aagcttcgta ttcagcttgg ctcatacatc cggtcatagt 15480 taaacaaata agtccgatta aaatatgttt cataatatgt ctcctcaata aatttaatcg 15540 gaactatatc acttatttta tagaagcatt aaaaatcaaa taaatcagct aaagaagatt 15600 ttttctcata atcaatttta gcggcatttg taaatgatga taatggttta acaaatgttt 15660 tgttaaaaag ttcttggtaa tcaagattac gtttaacaag ctcttctatt tcttgtggta 15720 aatctgagcc agaaggccaa gagatacatt tttcaccaaa tggatttcct tcttttaatg 15780 gaagaacttt aactttctca ccttcaaaaa taggtggtgc accatctaaa tttttagtcg 15840 aacgattata agctaaaacg cctttaacat ggtatggaca tcctttagtt gggaatcctt 15900 ctgcgtcaga atacttcata agattattag cacttgatac tgaagctatt gagctataat 15960 cgttttctcg gaattgtttt tcaaattctt tataatattc ttgtaatgat tcttcacctt 16020 cttgcaacat acgtcgaata cactctttta gtgcaacttg gcaacttttt ggtgtactag 16080 atttttgtgt ttctagaccc atgattttta attctggggt ttcgtatctg gtaccttcca 16140 tatcccagac atttaatgca tatcgtttct tagcagtcca gaatccacct aatcctttag 16200 ttcctaatgg aggaccagca atagcttctc ggtccataaa catcaaatgt tctctgttgt 16260 tcatgtattc ttttaattca cgataagctg tgtcaatagc gggttccatt ttttctgatg 16320 caaacttaga taagaaatct actaattttt gagtatcgtt attaaattta tgttcaactt 16380 tatctactaa attatctaaa caaacataaa ctgagtctgt atcacctgcg ataacataag 16440 aatagttttc ggttcctaat gttgtattta aatattcgtt aattttgcgt tcaatccact 16500 ggattgcaag ttgtccaaat aatgtaatgg ccgaagcatt tcttaaatca taatatctga 16560 agtaaatatt acctaatgca ccataacaag agttaatcaa taattttctg ttaatttggg 16620 ctgtattaga tgttacaata acccactcac agtattctaa taatttctct aaagattctt 16680 tagaagcagt atttaataaa actttaaagt cttcattaaa atcaaatcgg ccgtcaactt 16740 caggtaaatc attagtccca taagaacctt tatgtaatgc ggctttaaca agttctgcat 16800 tacgtttagc agctaacata tatcctttat gttctttacg ttgtaagaac actttttcta 16860 cttcttcagg aataacacct tgatatgatt tatcatacat ccaaccatta ggagaacatg 16920 aataaacatc tgatggtctt ggcgcagtct tattaatata gtcagccata ggtgcaacag 16980 gaaaacttcc tactattgtc tctggactta tattagcttg tctaataata ctcggatata 17040 ggcttgtaag gtcaaaactt aatacccatc ggtatgcatt aggaacaggt tctttaacat 17100 aagcacctgg atatccttgt cttaaatgtt gttttaattc aggaataact ttctttttag 17160 ctttaagtga attaaaaata atagcgtccc acgttttaat agggctaaat actgattgaa 17220 tttgcatttt tgaataatat ccaagagata atgctaattc aataaattga cgtttcttat 17280 caatttcttg cacacaattc acatcttcaa tattataact aatatatcta ttgtgatttg 17340 tcattcttaa tttattaaga gcacctttat attttagttt acctttacct gtttcaaatt 17400 ccgcgataaa gtctaaatta tacgtaggtt ggtttgtaaa actgaatttc ttgtaaagat 17460 ctaaataatc aaggactgaa acacccatga tatcgaaaat ttgtttatcg ccataaatat 17520 tttgaatgac tttagaacga atctttcgac atggagacat tctttttgca actcgttcac 17580 ctaaaacgtt tgtaattcta ttaacaatat acgggatatc aaatccttca acgttccatc 17640 ctgtaaaaat aacaggtggt ttttcttccc ataaacgaac atattctaat aatagttctt 17700 cttctgtttc gaaaggaaga taaacgactt tatcaataat ttcttgagat aattcgtcac 17760 caccttgatt ttccggtaaa gcagctaatt ttgcatccca tttagagaca ctaccaaaag 17820 cagaatttaa taagtcaaat acataaaact tatcatcaat cgaatcgtaa tgggtgattg 17880 catctatttc gtatagagct agttctggtt taggaaaatc agtaccagta acctcaatgt 17940 cgcagtttgc aatacgaatg tattttctat tatacataac gtcataagca taattatcac 18000 taatataggc caatttaaag tcatccatac ccatgacttc ttgacctaca tctttcattc 18060 gcttagacca atcacgtgca tcttggatag aactaaattt tttacgtgta caatactttc 18120 catagatatc tttgtatttt gtttctgttc cttctacaga atgccaaaat aaagatggtt 18180 catattgcac agttcgttgg cgttcttttc catctgaatc gatatatcgt tcaaaaatgt 18240 tattaccgat ttgttcaata tttaaataaa atggtttcat gattttccta gttttaattc 18300 cgagtgatta gaatataaat aaaggccttt cggcctttta gttaatgatt taattaccaa 18360 ttcgatattt gtgaattaat ttccagtctt ctttttgttt aaacgaaata acacggaaat 18420 tatgttcttc tggaagattt aatttctgcc cttcaataat atcacataat tcccaggact 18480 ctaataaatt cgcaatagag tcacgacgtt gaatatcttc ttcagagata tctactttac 18540 gaccatctaa ttttaaaagc tctttaaagt gaacaataaa atatttacct tgtttttgta 18600 aaatatgaca actttgataa agttcttttt tagaattatt tgcaatacca attcgggtta 18660 aagtttcacg aatttttaga aagtcttcag gagtttttaa tttaatttca atcataatta 18720 ccatgccttt ataagtttat tgatttttgt tctatcagtt ttatttttaa taacagcttt 18780 aagaaagtct tcagttacca tagcttttgt tttctttaaa aagtcagata aggttccttt 18840 agctttcatt atcttatagt attcatctgc atctcttgta ttaataacaa aatacataga 18900 aattaattgt aatattactt tatattctga atcatcatta tacttggccc atttgccgta 18960 tcttttacct gcttgtatag ctgctcgata ataattataa tggccttcat ctgacaattc 19020 agaaccatat agattcatgt aatgaacagg aataatacaa tcaacatgtt gacttaaagc 19080 gttatcaatc caatgttttg aatactgttc tttttgttca atagttaaat catctttaga 19140 aactgttatt ccatttaata tagcgaacat aacattttca gaattttctt tataagaatc 19200 tgctaatttt ttaacagatt cccagtcttg attcatccat gctagttcat gttcatttaa 19260 atcaggttcg tcttcaaata aattatacat tccatgttaa tcctactgct aaacttacga 19320 atgtggacat taataaaagt tctgtattag atgctaatcc aaaaaactta tttgcatcac 19380 caacagtttc atacatatga acaacaccca caggttttaa taacggatat aattcattag 19440 ctaattggag aataaatgtt ttaaaatctg gcgcgtattt aatggctaat acacgaagat 19500 cttttatatt ttttgtttgt aatgcagtaa taacatcgtc aagttgtgat ttcttatcaa 19560 caatacgtcc taaaatacct gtgtcaattt taccattgac ggaataaata tcaagctcat 19620 ttacagtttt acgtaaatca ggaaaatttt gttttaccaa atgggctaaa attttaatat 19680 cttctacttc aatattttct gctttacaaa tttctacaca acgtttaatc atatcacgca 19740 tcatagaaat tttatcttca tcagaagggt ctgtaaattt tataacacga gcacgtgatt 19800 gcaatggttt aattataccg tctaaattat tagcagttat aataatagag cagtttttcg 19860 aatatgtttc cataaatgag cgtaaatgac gttgtgcatc acctaaacct gcacggtcaa 19920 attcgtcaat aataataatt ttatttcttc cttctaaaga acctgaagaa gcaaatggag 19980 ttaattgtgt acgaataaaa tcgattttac aatcagcccc attaacaaac atatattcag 20040 aatttgtttg ttttgctaaa attaaagccg tagtcgtttt acccgttcct ggacttggag 20100 atgttaaaat taaatgtgga atacggccct ttttaataag ggcattaaac gtttctttat 20160 catgtttagg taaaatacat tcatcaattg tttgagggcg atatttctgc tcaaacataa 20220 actcgtcttt attaatagaa atcataatat taatttacct taaaatgtgt gattagattc 20280 ttgttccagc acaattacat atttaaatgt aggtgtttca aatttaatag cacctttact 20340 agaaatcata attttataat ctgccattag tactttcata ttattcatat taatgacaaa 20400 tttaaatgtt tctgaagatt cccattcacc gacttcaata gaaaataaca ctttttctaa 20460 attagcgtca acagctttat tgtaaccatt aataacaatt ttattatcta atgattcaat 20520 ggcaatagta tctgcaccaa cagctcgggt catttttgta atttgttgta gatcttcagc 20580 tttcaattca aaaattacgt ctgctactgg aaatccaatc ggatttttag gaactacgat 20640 agtacttaaa tctgctgttg caaaaaacac ttctgtacgg tcatttttaa ttacagcaac 20700 tcgttcttgt tcattatggg taattgtagc atcttcacca actaaggcta aaatatttaa 20760 aaaacctggc aaatcataaa taggcatttc tgaatcaatt tcatctgcga tagttgcatc 20820 agcataaaca gttttattaa ttgcacgtgt cataatgaaa ttaccgggtt ttaaaacaat 20880 acctggatta attgcactaa agtttttaag aatagttaaa gtatctttac taaatttcat 20940 tatattacct tatttgattg tttcaattac agaaagagca gcttttaata ataattctgt 21000 agtatcaatt tggaattttt cttcaagaat atctgttcca ggaataagtt ttgcaccatt 21060 tttgatagct tcttctttat gggctttcat taacttaata tattcttttg atacatcaga 21120 atcaatagac ctataaaaac taaatttggt ttcttttgga agagatttta atttagattt 21180 tttagattct ggtaattgcg atacccatgc ttgacgaatt gcatttttaa aatctttatc 21240 ttttaattta gtttctttaa tcatatacat cctcaacagt ccaataattg tgtctgttat 21300 tcattatttt aggaagttcg tctccgaact tctcttcaag ttgttgtttt gtaaccagta 21360 ttatatcatc tgtatatcta ttgcaaagat aatatttttt aatttctgga taagtttcta 21420 aatctgtaaa taaactcatt gttcttcttt aattgtaaat cgaccaattt tattcattat 21480 aatatgacgg tcataatctt gtggattatg gtcactatgt gaaataataa acacattatg 21540 gtcttccata gaattaagaa ttgacattat tcctttagag gcttcagagt ccatactacc 21600 gtcaaaaact tcatctaaaa ataatgtttt tatattaaca ccagatatca ttgatgcaat 21660 gtcatgccaa gtaaataaaa tagcagaatc tattcttgct ttttcacctt cgctaaatga 21720 gaaataagaa aatgattcac gtccacgaga cttaatggtt tctgcaaatt cttcatttaa 21780 agtgacttgg taatctgcgc ctaatttagc taaatgttta ttcaattgct tattaaacaa 21840 aggaatatat ttcgaaatta tagctccttt aataccagaa tcttttaaca tctctgttaa 21900 aatacctcta tgatattttt ccataaccat atcggtttta agtttaacaa ttttatcaag 21960 atcttttagt aaagcttcaa ttttatcaga attatcaatt ttttctttag atgcttgctc 22020 tattgcttca tttaatctat caatattatt tgttgatttg agtattaaac cagtaagggt 22080 ttttatttcc atattgattt cggatatttt ttgttcttga cgtttaaaca tatttagttt 22140 ttgttcaacg tctttagaca tatctgaaag cttaattaaa gccttatcac attttgcaat 22200 agattcttta atcattggaa ctttagatgt cccttggagt tcctgcatac aactaggaca 22260 actcccacct ctatcgtata aagaaataac tcttgagtaa ttttcttttt cagttttaac 22320 tttagaaata gcctgaacta tttttgtcat agaactttgt gggttatcac caagaacaat 22380 agtcttcaat tcttcttgta gtctggatat ttttgctttt gattctgata tatcaagtag 22440 ctgtttatct tttaactctt ggtaacggtc aatgttagca gatgacaatt tctcttgcga 22500 ttctgcaaaa tctttttgtg cttttaattg tgcatccaaa gaatcttttt tagcatctat 22560 aatagcaagt ttttggttta tttcacggat ataagattta ttaagtttat ccatgattcc 22620 tagtgtattt acgtttaaaa gatcttctac taattttctc cgttcagggg tcttttgttg 22680 cataaaaggg acaaaccctg cagtaccaag aacaattgtg tttttaaatg tttccatatt 22740 cattccaatc attaattcaa atttttcttg gaaatctttt acagaagcat cttcatctaa 22800 aggcttatca ttaaccttta tttcaaacac attaggtttt tgtccgcgtt taacaaaata 22860 ttcgtcagaa ccatatttaa accataactc gactattaag tcttttttat taaaagaatt 22920 aattagcatt ccttttttaa taggtctaaa tggtttacca aataatgcaa aacaaattgc 22980 ttctaacatg gtgcttttac cagcaccatt tttgccagta atcaatgttt tatgatgttg 23040 gtctaataca atatctatag gagcttgtcc aacagataat atattcttat attttaccct 23100 aattaattta aattctttca ttatgaatta accgattcca cgtgaaggct taaggcatac 23160 ttaaacaaga tttctttctc ttcatcagat ataccgtcta ttgcattaat gtattctcgg 23220 attattgttt ctaaactttc tacgataata tcttctgaat catctacatc aggtccttgg 23280 acattattct tagaaacaat ttttaaagag tgcacaacag attctaattt tgattcaaac 23340 tctgtaaaat tgtcatccat tttattaaca ataacacgga cagcaatatc tttataatca 23400 tcaggattaa tatcagatgg atattgaatc cgttgatgcc acattgtttt gttctgaaca 23460 aacttggttg tatggtcttt tggattaaat atccatacac ctctagggtc gtcctcatcg 23520 ccggcagtaa ttgaatacgg cgtaccaata tataatacat tgcctgcttc agaaattgta 23580 tggaagtgcc ctgagtaaac tttatcatat ttttttaaga aatctggttc tagaccatga 23640 gacttcatcc ctttataaaa atagaatcca tttaattccc agtgccctat acaaatttta 23700 gcattagaac ttttaatatg gtctaagatt tcttttgtat tttcttcaca catccatggg 23760 attaaatcaa ttaaaacacc ttctatttct actgtggttg gtttatcata aattgtaaca 23820 ttgctgtgct tagataataa ctcagataca gagttgggat gaattttatt tttgaaatgt 23880 aaatcatggt tgcctataat aacatgtaag ttaattccgg cttttttaaa ttcatttacg 23940 ttttctctag aaaattccat tgtgacatga gtgattgctt ttctaacatc aaaccaatca 24000 ccaaattgaa taatttctgt gattccattt agtttacaga cttctattac ttgtttaact 24060 gaatctcttt ggatattttg aatccaaggg tcgtctttag cgaccccata atgtaaatca 24120 cccataaata aaatcatcat aatatccttt gtcaattaaa aattatacca ttttttaatt 24180 ctagcagaat ctgcaataac ttcttcgtat ccatcaaatt tatatacttc accactgcca 24240 acctttctag cagtagtttt tgttaattta acgtagaatg aattagcaaa ttcaaacata 24300 gtatctgttt tgagtttttt aaatgttgat gtctgtatca ttttctttag cttcttcaat 24360 tattttaaac atagctttac gagaggtttc ataacaatat tctagaacac cgcgttctgt 24420 agattgttta taaatcttac gtaatttacc taaagcgtaa ataaactgtt ctttatttcc 24480 acttaataaa gattcttcgt ataaagtttt taaacgatta atttctcgtt tgttcttttt 24540 gagaatcttt tcggctcgtt tttcagcttc ggcttgaagt cttttttcat atttttctac 24600 atcagggtca atactatcaa tggtaatttc tttagattca ttcattatca gtccactcaa 24660 attctaagta taaattaaaa tcctctatag tgtatgaatg attaaatact ccctgtttta 24720 cggaaatatc ttcgtcatat acattaatag gatcaattat cacagggata ttataatgtt 24780 cttttaaaaa aagcttaatt aaatatggta ttgcgtttat atcgttatat tcttcaatca 24840 atggtgttag attgagtttc ttcttcaagt aattcataaa aatcatccaa tgtaggtcct 24900 gtatcactag tctttttaga cccactagat ttaacagaac tttcataaga agttaattta 24960 tcatatatgt cctgtataaa agtttcatca gcaatttgtg ttaaatcact atcaaactca 25020 tcatatacat tatggacaaa atagctatat tttattgcca tttcttttcg ttctttttta 25080 attcgttgaa cgaaggcatt aaaacaagcc atagtgatgt aagcatgtgg attattgtat 25140 ttagtttcgt caaagccata taaacctttt attgtggctt caatcccatc ccaatacatt 25200 tcttgtttcc aagcagctgt atatccagaa aaattatatc gattagaaag accttcagct 25260 ataagcataa tagctcgtcc tatagaatca ggaattttaa cttgatgtcc cgctttataa 25320 catttttgtt tccaatcaca aatctcttta tataattctt tattgttaat ataattattc 25380 atcaagaacc tccaagttaa ttatatacaa aaataatatt ttgcatttgc aatcaaggag 25440 cttcgctcct tgaaattctt tattattaag ttctttatat tatatataac tattaagtaa 25500 taaattaata actatagtaa actattttat taaaagtata gtatattcta tataactatt 25560 aaataataaa ttaataacta tagtaaacta ttttctaata tattctatcc agtcttttac 25620 tattttttgg tcttcttcat tttcaggatc tagttttctt cctagttttc ttaacaaata 25680 catatatcga tatttttctt tatctgtcat ttgatactgt ttttgaaatg agattctttt 25740 tctagtttgt tttattttag gcacttttaa catatagtca gtacatatag tcgaattttt 25800 aaaatacctt tcttttatgt attttgctaa tctcatatca ggaacaaata aattaacttt 25860 tttgttactt ttattaaccc taatatttgt tctggcacat aattggaaag ctggttctaa 25920 atatttagat acaatatatg catccactaa ttcgtcttct tctaatcctg ccgataatga 25980 caattctttt aaaataggaa tttgccatgg caaaggatta aaactaaaca tcaccacaac 26040 gttcctgtaa tcagtgtagg agtttaatcc gtgtggatta tatggaactt caagtccttt 26100 attaaaacgt gccctgtatg aattcctggt gtatataaat ggttcgtcac caatcaaacc 26160 atcaagaata ttttttattc ttgaataatt ggttaagcca ttgacttctt tatctgcatt 26220 atgtttagac caagaatttt caaacatcac atttatttgt attcttgatg tattagaata 26280 ttctttaaat accagtttgt cttctaatgg tgattttaca aaatcccact tattaaagta 26340 cttaagaatt ttaccagtaa aagtgtcttc tatatttgct gcagaaatag tcactttatc 26400 aaacacttcc caatctttac tagaaacatc gttgataaaa taacatgtgg ctccagtttc 26460 agatttagaa atttttgttg gaataccttg taataaagct ttatatagag gaagtaaact 26520 cacacagata tcatctaatt gattaagacc ttgtaatgct aattcttcaa cttcttcttt 26580 atatttttca tttaaaacta aatctgataa tccttctcca ataggcatac agaatttgag 26640 tatttcatct agattatgtg aaaacacaaa tttattaaat gatactaatt ctgggacttc 26700 gtcaatatat aaactaaagc cattaaattt actaaagtct gtaatagata ataaagcaga 26760 atgtgttatg aaaataacat cagatttggt ttcttctata gctttactaa cagatttaga 26820 cccgagttta ttgtcagaat caatcaatac cccttttccg cccaacgagc aaaaataatc 26880 aaaggactgc ttagataaaa gcctcgatat cgaggctata attgattttt ctttattatt 26940 gacaatatgt tctacaatag ctttagtctt tccagcggct gggattgctt ttaagacttc 27000 gattttcatt aattaaatcc atttgcacgt agttttttgt atttacgaat accttttgta 27060 gtaatttctg taggaccttt aatattaggc ttgacaccga acgcctgaat accaaagtta 27120 tttagaattg tctcaaccat aatttctcga ataccatttt tagaaatctg gtgatggtct 27180 ttgttgaggg attcatgaag aatttgttca tgattatcta aaaatcttgg agtaataatt 27240 gcattttctt ctaacatttt ttcttcaacg atagggaaaa tgtagttttt aatttcatta 27300 cgaagtgcct tactcataaa tatctccaat atatgatttt aatccagata aaccgccaac 27360 tggtttatcg tcaataaata tttgtgggta cataatacta aggttttgtt tattaagcaa 27420 ttttgccagt gaaataattg tgtctctatg ataatcaaaa ccatcttcag tattatataa 27480 cacaggaata aaattatatt ctatcccata ttcattacat aacctaatag cttctttaca 27540 tgaataacaa cgtcccacgt cttccggaat accataaatt gttatcattc actaacaccc 27600 aaagaaaggc ttatattaaa ctcatgtaat ttatcagggc cttgtacttc tattttagaa 27660 gtagccatat ttatccagat atattcatat tctatatcat gtggaagact aaaaagatta 27720 tcttctttta attcggcatt taaaaagacc acatctaaaa aatggtccca ttctgtgacg 27780 gtgtcccaat ttttaattcc caatatatta actatgtgat tactcatact cagaccactc 27840 attattaaat tttctataca ttttttgatt atccgaacca cgaaaaggct tatctgttgg 27900 tttagtataa tcgtactttc catctataat aacatcaaca tagtctaaaa gctctaatga 27960 tccttcaggc agatcattaa attcatatcc agtataaatc caaatagatt ttctagtttc 28020 ttcctttact cttttacaaa tattaataac ttcttttata ttagagcgat acaagggatc 28080 accaccagag atagtaagcc cattaatata tggtttatta accatagtga ttaaatattc 28140 cagggttgat tctgtgaatt cctggccatt acgcgggttc caagtagact tattgtaaca 28200 ctgttcacat ttatgagaac accctgtaac aaatagcact gttctaaatc ctataccatt 28260 taaagaatca catggaataa tagatgcata attcatttta tctccttagc aaaaaagggc 28320 cgaagccctt taattaactg tatgcataag cttcattgga ttttttctta taaaccaaat 28380 cagtccttag tgtatcatat tctgggtttt caagcacttt atttaaaata tgtcttttat 28440 ctgctcttga taatttagct tgagccgttt taacttcaga atcaattcct ttccaacgtt 28500 ttggtttatc ggaatggaaa atattatctg caacatcatt agggtcttta tatgctcttg 28560 ctgttcttga agttttgtcg taatagccat tattttttaa tgtttttctt ctaacagttt 28620 tacccataat aattccttat actaatagtc taattaaatc agaaaacccg ttatcttcta 28680 gttttttaat attcttttcc aataagcctt taccataagt aaaatatcca tcttcagctt 28740 ttataattgt actttggcct gtttcagggt ctcttgctat tgctaatcca tatctatgga 28800 gaatagtagc attaataaca tataaaagtc ctaactcaga catatcattc caatctaatt 28860 cttctttttc aggaattata tttgcacctt ttgaattttg catattaagc cttaatatgt 28920 tttgttctat ggataacttc tttttgttta ccttcgttaa acccacgaga agcaggattt 28980 ccaagatatc cacaggtacg acggacaaca gacattttct ttacatccat ttcaccacat 29040 tttggacatt taaacccatt ttctgtagga ataaattctc catggaattc acatgtaaag 29100 cattggtcaa caggagtatt tgttccaaaa taatctagat tttctacagc ataatcccag 29160 acctgttcta atgcatcaag attatccttc atattaggga gctcaacata agaaatatga 29220 ccaccagttg caatacggtg ataatccttt tcaaattcaa ttttctcaaa tggattaact 29280 ttacgttcaa catcaagatg gaaactattt gtgtaccaac ctttatctgt aattccttta 29340 acagaaccaa attctgcctt atctaattta cagaatctgt ggcataaact ttctgcagga 29400 gtcgaataaa gactaaacgc gtatcctgtt tcttctttcc acttagaaag ataatagttt 29460 atttctttaa gaatacgttt accaaattct tgggcatctt tattatcaaa tggttcatca 29520 tcaaaaatta attttaatgt ttcgtgtaaa ccaatataac ctaatgaaat agaacttcgt 29580 ccatttttaa ataatgataa tatttcgtca ttagggttca tacgaacacc aaaagcgccg 29640 ccacaatata aaattggagc cacagaagct tttgcaccac gtaaagaatc aattctagtc 29700 ataagagcag tataacagag gccaagacga tctctcaatg attggatata tgattcttta 29760 gataaattgt cactacctaa ttccagggct attctaggaa gatttaatgt gactacacct 29820 agattattgc gcccatctaa aatttctttg ccattttctt tatagacact taaaaaagat 29880 ctacacccca taggagaaac tgggaccgaa ctaccggtta tttctttatt aattttagac 29940 gaaataatat ctgggtacat tcttttagct gaacattcta atgctaattt tttaataaaa 30000 taattagggt cttcaggttt aagattaatt ccttcttcaa taaagaagac taatttagga 30060 aatatcgcag ttacttcatc tttgcctagg cctttaattc tatttttaag aatagcttct 30120 tggataactg tgccggccca tgaagtagaa gttccaaaag aaatagtcac aaatggcgtt 30180 tgcccattag agctaaaaag cgtattaatt tcatattcgt acgcttggaa agcgtcataa 30240 acatcttttt ctgtcttctt catagcataa tcttcccaat caggaatacg ccattcaaaa 30300 gcttcattaa gatgtttttg gtatgtagct tctacgtaag gctcaagaac aacatcaaca 30360 tttgcaaatg ttgttccacc atattgatga gaagcaactt gggctgtgac ttgggccata 30420 attgcacaag ctacaccaat tgatttaggt gtttctattt ccgcgttacc aagcttaaat 30480 ccattttcaa acataccttt taaatcaact aaacaacaat ttgtaaaagg cagtgataca 30540 ctataatcta agtcatgata atgaataata cctttgtcgt gtgcttctac tacattagaa 30600 ggcaatctac tacgagccac gtacttggaa gcaattccgg ccagcaagtc acgttgtgta 30660 ggaaagacac catagggctt gtttgcattt tctgtagaaa gttcatttga ttcacgatta 30720 catacctcat taatttgaga aattagattc attttaaaga tttccttaaa gcttttttat 30780 atcttttagt taactcggtt tttgtatctg tttctagata ttcaaatccg tttattatca 30840 tttcttctat catttcttct ttagacatcc gagagaactc tttagattta tctattatat 30900 actgtggatg gataggattt tcactgctgt cttgttttaa ataaaataat aaattttcca 30960 tccaagtgat atattctact ttagatttta atcctgaacg attaaattta tgcttcattt 31020 gaccttctgc tgcattacat aatgcacaca ataatccacg gactttacct gcttcagggc 31080 cagataatga atggtcatga tctaaatggt tcttttggac atctttatct aattctaact 31140 tgcaaataca acaaaggccc ttttgggcct tatacatttt ttctttttct tgtttaaatg 31200 attttcctga taataacatt ataacctcta taatttatca tatagaggta tttattaaaa 31260 attataactc accagtctca taccattttt gttcttgttc ttcactatca aagaaacctt 31320 caagacccgt aggtaaagca tttgaaattc tgttcaataa atcatagagt ttattatttt 31380 ggtcttctag ataagcaata cgatctttat cgttcattaa tatattcctt aaatttatca 31440 aatccaccaa tagacacatc atctataaaa atctgtggca tcgttaatcc aacttctgaa 31500 cgtcgattta gacgtttgac taattggtct ataatttttt tatttaaaac aggcccttca 31560 ccttcagaaa ctgggataaa agtgtaatct aattttttaa tatcagctaa tcttttggca 31620 ttaatacatg gaacacattt aaagtgttta gggtcaaatc cataaatttc tactttcatt 31680 tagatggcac cattttagtt aaactttccg ggatagtgaa tacagataat ttaggatggt 31740 caacccaaat ggttttttct acagtaccat catcttctat aataatttct tcaaaaaacc 31800 cagcttctct gaaatatttt ccggctacag tagaaaattg ttctctatta agtccatatt 31860 tagccaatac ttcatctgtt acttcttcat tctttaatat ttcaatagaa gagatgtatt 31920 ttagtggttt acgtgataat tgcataattt gccctattta attaagaaat taatatatgt 31980 ttttataata ctagtaataa attcccaaat ccaaataaca ataaccataa ttaaaataaa 32040 tggccataaa aacattaatt ggaaaaacga atatactaac ttatccgaaa atttttcttt 32100 aatattttta tcaaatttaa atgttagaga tgctataaca aatgataata aaacatatcc 32160 tacaatatat aaaaacatag ttatccttta taaaatgttg ttttacaatg tctacatttg 32220 tattttaatt cttgtaccca agagactagc tgaacctgat aggttccaca tccaggacat 32280 tgtggaatgt ttttagaagc gtcttcacga cgcttaacaa ttttttctac ttcttcccag 32340 ttaataatat ctttatgaag gaccattctt attccttaaa attataataa cttttcactt 32400 cttgaagata aacatcatgg ataaatttat cccagaattc tttatctaca gtctttggta 32460 atccattttt tgcagtgatt ttagcttttc tttcaacatc atctacaatg gattctagat 32520 tctcttgaac aagtttaaaa tcaattttac ctgctttgat atctttaatt tgtcctgcca 32580 tttgtaacgg catcactaaa tcaccagtat catagatttc tgctaattga acacctgcac 32640 gatatgcatg gcttaaagct ttccaatcaa taccttgatt ttcttcagct ttacgggctc 32700 tatcgccata ttcttcccat agcttatata atgatttgta catttcatct acagtaatag 32760 tcatttggta tttacgacct aaaacttcat agaaaacctg agttgtacct ttatcatcag 32820 tttgagaagt gaataaagca aattctaatt taggaagtag gtgtttaata attccaactt 32880 taacttgttc agaaaaatta gatgaagtat atggagtaat tatatcaaga acgcgtttta 32940 agcaagctaa tctggaacct ttaattccat attttgcagc ttgtttacgg acatatccta 33000 aataagcctt catatcagtt gtataaaact tagaacggtg ttttctaata aagtcccatg 33060 tttctggtaa atctgaatga acaaccattt cattaggggc gtggattaaa tctagtgcta 33120 cagtttcgcc acgtgccgcc agggtcaaaa agtattttaa cgaatataat tcatgatcaa 33180 catcagaaga agtgttctta gatgatcctg tattggtatt catattaaag tgttctgtta 33240 cttgacaagt cacaatacta tggccactag ggacaaaaat ttctttataa tctaaatctg 33300 attctggtgt agaggttcca tacaaatggg aaccaaataa tactttagca acggtcttca 33360 ttatttacgt cctttcataa atctaaaaat acccataaca atataagctg gccaaaatat 33420 catatccata ataaaagcca tggcgttatc tttattagtc cattttactc taaggccttg 33480 tctaatttca gtaaccatag aaactaaagc tactaaaaat gaaattaaaa gatacgtcat 33540 ttggattcct tttcttctaa agatttaata gtatcaagat aaatggtttt agctttttct 33600 ttatccgaaa catattcaaa taggtaatct aaagcctctt tagagatatc tttatatttt 33660 actttccagg gtttataata tgatgcgagt aattggtctt ttttaaataa ttcatctaat 33720 aaaggaataa ctttcatata atagaataaa catgttccta caacttcaga aatatattca 33780 tcttttacag gagttcctga tttaattaga ttgtttgtaa tttttaaatt aaagaaagcc 33840 gttttgcaat cagataaaac tggattatta aaagcataca gatcttcaca taattcagta 33900 atgcgttttt ctgctttctt ttgtttagga gaaggattaa ctaatccacc aaaaatttga 33960 attggtggat aggccgcaat attagaaata aaactttgtt gaattgataa agacataagt 34020 tgtcctataa gattaagctt tcatccatcc ataaacagag tatttgatgt taaaaacaat 34080 tggttctgaa tatgtataag ttcgtgtcat cctattatac ttaattctaa tatctgtagc 34140 gtcaggattt gaaaaaacag ctactggatt taaaccagat ggagttattg aaacatctga 34200 cttaaatttg taatcaatac cattaatttt gtatatttta ttttctttta acataataat 34260 cttaaaattg ttgtacatat tttagttcaa aggctttcat agcacttgaa tcagaaatac 34320 gaattaaaat aggttcttgg tctgaatgct gaataagcaa agttgtatct gttatataaa 34380 gtatagagta ctgttttcct ttagcatttg ttattacatc accaggtttt gcttgaaccc 34440 atgaatagcc tttagtttcc ttacaatatg tcatagtatt catattaatt aattttctac 34500 tgggtccaat tcgtaattca atttctagat ctttaggaat aaatgccgaa cctaaaaaag 34560 aaaaatcgta ttttacctga tctaataatt tgtatacctt acctatagca catcctcgaa 34620 taaaactatc aatttttaaa aacattgaac tgcttaattt ttcaatacca agaattttgg 34680 cttcatacac aataggagga ggtgttgata ctaatataaa gttttctaca gttggtgaat 34740 atttaaaaat tacttctact tcatcgcctt cttttatatc tacattgtcc gtagaaacag 34800 gaccgtattt atgtgttaaa ataggcatat taatttcctt gataaaattg ttcaattaca 34860 gatttaagct taagtgcttc ttcttttgtt aaaacgataa ggtcttcatc ttgcataatt 34920 ctaatagccg atttatcaga aatagaacgg ctcacttcaa tgtcgcccat gataaattta 34980 tcatttgtgt tccacataaa aatctccata aaggcctttt ggccttatat tatttaaatt 35040 caataaagtt acaatgtttg tttttaaatg attcgtgaat ctcatcgctt aaagactttt 35100 ctctcacttc aaggtctttt tggatattag tttgatgttc taaacgtttt ttcagtctac 35160 gctgagccat ttttctaggt aaaaagtctg caaacaacca aaccccacca acaacaatta 35220 aaaataccaa agcacctaaa actgcaaata aaattgctcc taaaatataa gcgccaatag 35280 ttaatccagt tcctaatgta atgccaaatg aagctaaaat atgaataaga actgtaccac 35340 caatattggc aaatactaaa gatatacacg aaataaataa tgcactaaac aacccacgcc 35400 cgaccaagtt ccaaaaatat ccacaaatac ttttaggcat actatcttta ggggttatta 35460 attttgttaa tttataatgc caactgtctt ttttaatttc aattttaggt gcaacgtttg 35520 ctaaacgaat atcgacaata tctgaacccc acacacgata tttaatacca acaaccttaa 35580 aattagtgcc atggacatca ccgtttgaat aaactacaat atcgtgtttt aaatctttta 35640 cattttctat aagaacatta gcaacttttg ttgcttcttc tttagtttcc cattccgtat 35700 ttaaacggtg ccatttcgga gtattaccgt cattaatgaa caattcaatt gtatacatta 35760 taattcctta aaagagttta acaatagttt aaatctacgt aattcgtcaa catcaacacc 35820 agatactata agaccactaa attcaaaagt ataatctatt tcatctttat gcttcaattg 35880 aaccaaagtt gttgttctac gatttaacgg cccataatta atggtctttt taattcttgt 35940 aggtaatcct tcatcaattt ctgtctttat ttgcatttaa cctctgatat ttttcttata 36000 ctggttaggc caagtattag aattaaaggc ccaaattaaa acggctagcc atccaaaaac 36060 tgtccatcca aaaacaaaat tagaaataaa aatagaagtt tttgcacaat ggtctctatg 36120 ccatccgata ataaatggta agaaataaaa taataccata cctattaaaa ttaagagttc 36180 cattgttctt cctttttaat taaacgagaa gcataaggga tttcttcatt gaaacgaaca 36240 aatcgttctt tttcaattaa taagcctaaa ccatacacga caatcccagt taagccaaca 36300 tacatgacaa tataatccat tgactcacac ttgatttggt caccaatatt aaatgtacct 36360 agttcagaaa gtttcatata acctacttat tcattttacg ttgaagatca atttgtcgtt 36420 ctttaataag acggtctaat tggtcattag ataaacatac acaatcattg ccttgatgta 36480 aaacataccc taattcattt gtagaaactt taacatcaag atttttgtgt aaacaatcag 36540 ttaaataaaa atgcattatt cctccaaaaa cttctttttg tgtttttgtt tacgatttga 36600 ttctaattca gctttctttt tgtctttgtg aacagaagct ctattaaaat catgtttagc 36660 tacaaaatta tttttcatat tacctcaact gtgaatcttt agaaccccgt ctgttgtaat 36720 aagatgtggt gataatatca tggctttctt gacaagtaca acaataatta caatttttta 36780 ttatttgtct acgacgttca gggatctctt caccgcattc aagacagtat atatcattgt 36840 tgtacgaaga attgaccagg cttaatctgg cccactctat agcatcttta atgacagctt 36900 ctttagttgc aaagccatca tctgaaggac cccatccatt cattttttca ccataaagtt 36960 ataaatgaat cgatacactt catctggatc tttttgttcc cagatatcta atttaggttc 37020 atggccaata atgttttgat aatgtttata tacatttaaa tgatttgaat gtaaccaatt 37080 aacaaaagcc tggccgatac gttggaatcc ttttacggat tcttcattcc aatacatata 37140 ccaatcatgc atatcgcaat aatttaaaag tttaggaact tctttttgaa gattatcaat 37200 aaatatttgc ttctcgtgag cagatagtga ttcaaatttg tcaagagtca tattcaacct 37260 cagaatttaa agtttttaga atgatactgt ttatcctgtg aaacatgttt atcagaagct 37320 tcagcaatac caatttttat aggacgtgca gataaacggt ctttgatatc tactttcttt 37380 tcaaattgcc cacacaacaa ataaaataaa cgttcgttag tcatgataat ctccatttga 37440 tttgatgagg ctatactaat acataatata gccttgtaaa cacatttaaa ttttttcaaa 37500 tccagattcg tcagaatcat tttcatcata aaagacagta taaccttgtt tagataatga 37560 atcgactaaa ttacccataa tctcagtgtt atcttcagaa tgattcattg atagataaac 37620 ataattatta tcaccgacat attcgacata atcattattg gtttttgtaa caacaaaaat 37680 agattttgat aatctattac gagtaaaata tactcgaaaa caatctaaat tataaccaat 37740 aatttcacaa acagaattca ttttgtttct ttcactaata gaagctatag agtttactgg 37800 cataccaaaa ttcagttcat ttgattttgc attcattgta ttgataatga cattaactgt 37860 tttaatggtg tcatcacaga ccacaagaac tttactagat acgctcattt tattttcctt 37920 caaggtcttt aatcatttgg tcaagaatca tattagtagc ttctacaaga atacttttca 37980 tcgaattaaa catttggcca tcggacattt tagaaagctt aaagtaggtt tcccatccag 38040 gttcattagt aaattcaaac tgtttagttg taaaaaactc ttttactttt ttaacatctt 38100 ctactgttac gagtttatta tcctggattt tgttagccaa tgcttgttgc acttgttttc 38160 gttctaaatg gatgacttca agctggtcaa taacatcaga ccaattcttt gtatattttt 38220 ctgcatcagc aaaagaataa aatgcaaaat ttttattata acgttttgaa tcattacctt 38280 taataatagt gttcatatca gataatgatt tacatgtttt aaaaccattt ttatcaatac 38340 aaacaaccca ccagatcagt tctgaactaa aagaaaaact ttcttgatgt ggcttagcta 38400 ctacagtata tttttctacc atattaatag gagtaccata tggggttgtg ccatacccaa 38460 cataaaaagt aaatccagga acaaggtctt caaatttaat attcttaatc atgataatcc 38520 ccacttgttg ttgttgtgat cataatatca tgataaacca ctttgtaaat actttttttc 38580 aataaaacca aaaaaggaac ccgtaggttc cctatgataa tgataataaa tactttgttt 38640 tcttacacag cgacataatt tcatctaaag cagattgacc agcactacat gtcgagtcat 38700 aaatgtcttc tcctaaagaa ataattgtat ctagaatttc ttggtccgac gatattcgtg 38760 ttggaaaatt cctggtataa gtaccaccac ttccaagata gatttctaca aatgtatcta 38820 ttaggtctgg catatcttca taaaaatctt cgtatacttt atggtgggca taacttttag 38880 tctcaaaatg atatgagtgc atatatgaag aacttattaa gcatagtcct ataaattctg 38940 agtgtttagt gcttttaggt tttacaaatg ccgaaaattc attcatcgtg aactaattcc 39000 tttttaaggt tgtacacata ttcttgtgca gcactttttc catcttcgct gcatttgttg 39060 ttttgacagt tagtttcttc ccattttgtt ttaatgaaag cataaaactg tactgattct 39120 tcttttgatg gttctttcaa tttactatac acggacatgg cgccttctgc gtatacgtta 39180 aaatatttat catcagatgc ataggcacta gacaataata tgcttaaaca taatagaatg 39240 cccgataaaa agtaattgtt gaatttggcc atacggcctc caatatctaa gtaatccaat 39300 taatgatata tagatttcaa tttataaatc atcttgacat cagagaaata gttacttagt 39360 tttttatatt gcaaatagtc tgcatggctt tgagtagtat taaattctat ttctgattgc 39420 tttaaacagg gtttaatttc tttcatatga agagccaatt ctattgctga catccgttgt 39480 aactttttct tagaaagcat ttcagtgctc atataattct cctagtcagt ttatattatt 39540 tattaaattc aaaataatgt ttacgacaaa acgaaatata tttatcatca cctcctattt 39600 caacaacctc accttctttt acaggattac cgaatctatc acttttagca gtatgcgttg 39660 cttttcttcc acaataacaa acagctttaa gttcttctaa tttatctgcc catgacaata 39720 aagcggcaga gccttcgaac agttcacctt taaaatcggt ttttaaacca aaacacataa 39780 caggaatatt atggatatca acaaatttag tcaattgaat aacttgttgt tttgttaaga 39840 attgtgcttc gtcaataaga acacatgaag tttttaatgc tgattctaaa tatttttcgt 39900 ataaattatc agaacaagaa aataattcac atggttcttt aataccaact ctactagata 39960 taacccctat atctctggtg tcaatatctg gttttaaaag taaacaaggc ataccttgtt 40020 cggtatagtt attattaaca gataataatt ttaatgattt accagctgcc atagatccgt 40080 aaacaaaata tagttgtgcc atgttaatcc ttaatccatt ctacccacag aacacactct 40140 gcgtctttct ttttaccggt tttagtttta tatgtatata ctactttatg ttctagaaac 40200 ttaataggct tgacatctgg ataactatta gtttctctaa tagattcata atgggataaa 40260 gagagaagtc ttccttctct ctgcatttta aaaggatgtg gtaaatgagt catttaaatg 40320 cacctctaaa agcaaaatat acacaaatag ctaaagcagg gaaaataata acagaaatca 40380 taatattaat aaacatctca ctaagtaaaa attccatata ttcctctaaa ttttctgttt 40440 tagtattaaa taaattacat taacgcaaac ccatatccac atcataggcc ataataaaat 40500 taatccaata aagataatat tttgttttat cttatcatgt ggatatccaa agcaccacaa 40560 aaaattagat acagtgaata atccacaaaa aagatataag gcgataaaaa tagctaaaat 40620 agacccaaat atcatttcaa ttctttaaac ttcattttat catgaccatc aatacgatat 40680 gtcccatatt ggcccacatt atctataata ttaacaacta tttcaccatt gcaaactcta 40740 aacaacctgg ctaattttgt gacttcatat ttgttaataa taaattgggg tcctaaaaga 40800 tctccatgaa ctactctatt gcacccagag acaaaaaatt ttccattagg aatagagata 40860 gagtcggatt tatcaattaa agaataaaag gtagcaccaa aaatacgttt tttaggttgc 40920 catactattt ctatattaga ttttttaagg ccagcatttt ctattaaaga ccctgatatt 40980 ccatataatt taggattgtt atatccagga acttcatacc atgaaaaact ataagaacta 41040 aaaaatataa ggcatgctaa taaatatttc attggtttat ccctgctata tatttgtcca 41100 ttaaagcccc tctatatgtt tcacagattt cgctattagg tgctttctca cataatgaag 41160 ataacgaatt ggctttattc ttcaaagctg atattttata ctcagcatct tttttggatt 41220 gtaaaaatcc ttcatgaaaa cttgtactta attctactga tagaatatta atacattcta 41280 tatcatcacc acaaaaatat tttgcaacat ctatagactc ttccatgttg ttagatgcaa 41340 taaccggaaa tgttactaaa aataacaata aaagtttttt cataacttac tccattgttt 41400 ttcctacaat agatttagat ttaagatatt ctgctattgt tctgacttca taagaatatg 41460 tttgtcctgc tttatatttc cagttataac ctgcgttata actagctaaa gctttattaa 41520 tatctccttt atgaactttt aaccatgatt ttaattcaac atggctccaa taagcagaat 41580 tacttctatc taatagttct tcaattatat cagaatcagc tttaggtgtt ccggcttgtt 41640 ttaaccgatt cctaatagtt ttgatataat tttggaacat accataagca tggtggtttt 41700 ttccggtaaa ctaccaaatt agggttttca taccctgaac tttctttaaa cgctatagca 41760 gcaaatatat acccaagatg atcttcatcc ttttcaaaat ctcttgggtc tccgttttta 41820 ttgaattgtt gaccaaaatg atatgcataa ttcagattat catattgttc ataagacaaa 41880 ttatcaggta aatgcactgc actacaggaa atagagacaa ataataatag aactgttaaa 41940 tatttcaaaa tttaatcacc tttgttgaaa ttttagatgg taatctagaa ggattgaaaa 42000 taaccatacg acatgtcaat ccatacgttc cttgtgttcc ttcagaagaa gtaaatccaa 42060 tccatagctt cccatcagta atttctaacc ttgtaggttt gtactctata ttagggtctg 42120 gattttctat aggcatatca ggaagtttac agtaatctaa aatagattct ttagcctgat 42180 ataatttatt taatagacca aaaatatcac ttaattgaat tccacgttct agtgttcggt 42240 cgataatatg actaccaaat ttaatatgga accctgcatt ttctttattt aaatttttat 42300 ttatttctga aaaagcctca gaaaattttc ttcgtgcttt tgcacgttct acatgaatgt 42360 tcattattta gactccaatt ttttaccata atatttatac caatctggtt tttgagcaat 42420 tttttcatct aatcttgatt tagataacat aatatcagtc tcagatggaa tatagtcatt 42480 ataccacgat ttaggaaaaa tgaaatcagt tttttcaaaa gaaacattaa aaccacgatt 42540 tttacattcc tggattaaaa cgttttgtct ttgttctaaa aattttagtt tattgtaaaa 42600 gaatttaaca tgtcctgtac caagaacata atttgcagga attttgattg gtttaccata 42660 agctttaagg gccaaagtaa atacacgtgg aagttcgcga tattcagcga taagatgttg 42720 gtctgtaaga agtgatgggt ctaaaagatt aatacgtgtc atatatcctc cattaatttt 42780 aaggataata taacacgtat ttttattaat gtaaactaaa ttttatcagt aaatgtcctg 42840 ttaataacat cttctttctg ttctgtagtc aaagaattaa atctaactgc atacccagaa 42900 acacgaattg ttaattgtgg gtatttttca gggtgttctt tagcatctat caacatttct 42960 ttattaagaa cattgacatt cagatgttgt ccgccttcga ttcttggagc aaactcaata 43020 gctaaatctt tttgggcaga attaccaaaa gaagtcattg aaactacttc atcttcttta 43080 aaatatttag aagccagaat tctacaatta ttagattcag tatctatcaa gaaaatagtc 43140 ccgtaaaatg ggcctgaaac taattgtctt gcttgaattg ccattatttt accttgtaca 43200 tgtaaggttc tgtagaattt tcatctttaa caaaaccata gaattttgtg tctacataaa 43260 gtgcaataga atttttatgt ttaatccaaa ctaaagaaac taaattttca gaagtactaa 43320 aacggccttt tgcttcattt aaaatcataa tcacattcct ataatatata caacaggttc 43380 atggtttaca catttaacta cgtcagctaa attgttaata aattcattag gatttaagcc 43440 cataggttct tcaataataa aaataggaga atttaaagtt atacctctaa atctattata 43500 gaaactagga ttcattaaag atctattttt aacggatata aattctacat ctttaatagg 43560 cttaatgcca atttcttgaa ttttttctaa ataaagacgt tttgtattaa tagcagttct 43620 tcctaaaaca aaaatatcgc gttttggatt tttgatcttt tgttctaata caaatttagc 43680 aacatctgtt gatttgtatg tctgacgtcc aaaatctaat ttgcattgtc tgtattctgc 43740 tattctagca gcaaatgtga atggcttgag cctttgtatt tcttcttcag ttaagttttc 43800 gcatttattt aaaaatttag tcattagttc taagtagttc atttttattc cttaggcgat 43860 atacgaatga aagtatatca cgaagtttaa gtttaaaaga tataatattt tgaaaattta 43920 gaaaatattg tatcttcttt tgtttttaat accataacag gatatagacc tttatttccg 43980 tcatcaataa tttcgtttat ccaattttca aaattggctg aaattaaatt aataaaacct 44040 tcaggacttc cacgttgttg gtatcttttt atgtattcgt cctttaaaga tacatcagga 44100 actataacat aaaatgggac tttttctttt actaatgctt ctcgaacttc tttgtgtgat 44160 gaagcaaatg ttaaagtctg ttcatatcgc atttctttta aatgcttaat atagttttgt 44220 ggaaattcag atttatcaaa taaagaagaa tcagaatcag atactttaat gccatgttct 44280 aaaaactgtt ttgtggcata gcttttacct gtaccaggaa aagcacacac aatactaata 44340 ttatcaatca ttagtcgact ctttaatatt tttatatttg aaagtgtggg ccatcaggaa 44400 acgatttcca gtctccaccc cattcgattt taacaccaag ttcttttgct gcttgcttca 44460 tagctttagc tacaagttca aacttggccc agtcttgcca tggaatatct ctattaacta 44520 agggtcctaa atctacggca tcgcctgtta aatgacgact atttaaagtt ttagagacgc 44580 cttttttaac attttctttt tgtttttcaa gtgtacgaac gccttcaata accataaaat 44640 ctatttcaga tatctggatt gctcgttcta caactttaac taaatctgga ttaacacctt 44700 ttaatctatc ttttgatctt tgtgataata cgtacataag tttctccttt gttgtcttat 44760 gtacatattt attagattaa agaggcttat aatctgtagg cagtgtttta agcatagata 44820 agaaatattc agtgtcgatt gctaaatctt ttttatcaac ttctaataca tcttcattta 44880 gaaaatgata tttttcgacc atttctttaa aataagccaa aatgtcatta tcacattttt 44940 ttgatacgct aatttcatta tctatagatt caaatccatc ttcatatgta gtatatccaa 45000 aaatactaaa acatagatct tttagttcta atggattttc tatatccgga aagtgctttt 45060 taagaagagg ttctaaatct tcgccatatg ttttaataat acagggcctt aattctaatc 45120 taatagtgca ttctaccata tcatgtttaa tacgaccacc ttcttcaagg tcgccaattt 45180 ctgtaattaa attaaacaat tcatcatctt taataatcat tttttattcc ttattcatta 45240 gtagtattca tagaaatctt ataaatccat gatactacaa tacctttaat aataacttag 45300 attgtgattt agagcaatat ttagggatgt cttttaaatc aacccattta aatgcatcat 45360 tttctgggaa tgttttgcca tatttggtat acatacttgt acatacacat ttttctacat 45420 caggcatatt aggacctttg tataaaaata aatgcatgtt tttaccttta tagtaaaagt 45480 gttcatctag gtctactaaa ttttcagggt cagtaacagt aaaatcagtt tcttccttaa 45540 cttcgcgaag agcagcttct aaagcatttt ctccttcatc aatatggcct tttggaattc 45600 cccaataagg tgtattagtt gcgtgacata aaaggatttt gtcatcttta ataaaaataa 45660 ttccggaaga gatttccatt tttaatcctt aatattcggc atcataaaga cgattaataa 45720 cttcttcaat cattatcatt aatatatgga taaagatttt ctagaactgt ttctaagtct 45780 ttaaacccat gtcgttctaa cgaagatctt aaaccattgg tatcattctt aatcacatat 45840 tcaacccatc ggtctttatc cataccttgg acttcatatt cccaaacgtc attccagttt 45900 tcgaaatgcc aactaccata ttcttttcgg gtatcaaagt ttccagattc taatcctgtc 45960 aatttgatac catcaataat aattgcccat tcaccaaaac ataatgaagg ataacttccg 46020 gaccaatcta cagaaatttc catagtattc cttataaaca aaatacaaca gcagctaaaa 46080 atataaagac aaataatggg atataccaaa ttgtcttaat cacatcatta ggtttttctg 46140 tatcaaacat atatcacctt agtaataaag agtttggcct acaaaaattt tattttcgtc 46200 tacaatgttg tttaaaattt taagatattc gatagaaaca cctaaattta gtgaaatatc 46260 gcctaatgta tctttatacc gaacttcata tgtcattaaa tttgaatcac ggttaataga 46320 tgctgttaaa aagtcaatag aattaaaaac ttttaaacta ataacttcgt cgttaccttc 46380 attataccca ataccacgtt taactataga aacttcagat ccaaattcag tttcaattgc 46440 gccaataata ttccgggtat caaccataaa tcgagactgg ttttctaaag aagtcaaaat 46500 aattttcata atagatcctt accagctgaa ggctaaacca gtaccaactg tagtattaga 46560 ttcactgtca aaggccccgc tcattttgaa tgatacatta ctattttcag gactagcacc 46620 aaagccaaca gcaacagcag aaccagattt ataaccacct acacctagac ctattgtaat 46680 agttttagaa aaatctaatg gaatgttatt cattgcagca gaagatgcaa aaccggcttt 46740 cattttgtcc attttattat caatatcttt attatacata ttccatgatt catttactgt 46800 accttcatgg aatgtatgat ctggggttgg gctaatccaa ttgttgtcag atgatgccat 46860 agcgtttatt gataataatg cagttaatgt tgcaacaact aatgtaattt tcataatagt 46920 ttccttgttt tgtttaagtg gaataatctt aacatataaa agtataaagc aataattatc 46980 tatcaaaaac aaaaaaggtc caacatttct gtggacctta aaagcaactt cttttattat 47040 ttattttaaa tatggcacac ccacggagaa tcgaactccg gttacctgct cgaaaggcag 47100 gggtccttac cgctagacga tgggtgtata aaatgaagga gagtatggga ttcgaaccca 47160 tggagcacct tccagtaccc aacggttttc aagaccgtct cattaaacct ctctgacaac 47220 tctccgagat taaaacaaca tactataaat tgaaccttta ccaaaatcaa tttgttgggt 47280 tttagaatat tctttaaata gttcaaaatc accaattaat tcaggttccc attgtccttc 47340 taaaccataa catgaacagt gggagccatg tacttcccaa aattgtccta atgtatcgac 47400 ataaattaca atagcgcatc cacaataatc ttcacagtca taataggcta aaacaatttc 47460 tttatctgct aaaacatcag gtggaatttg gaattcatta caaatatctt ctttggaagt 47520 aaacaaatcc ataaatacat tggttttcat attattctta caaatattat tcatattacc 47580 ctcacaatta atttggcggt cttaccgaga atcgaactcg gtgctgttcc gtgacaggga 47640 actatgttaa ccaggtacac cataagacct aaaatattac ccatccggtt ttccagtttg 47700 gtgaagggtt gtcacctcta gttttaacct gctagtcaag taataattgc ttatcgtcca 47760 attatcaatc ccgtctaggt tatattacac cacttcctag aataccagag atcttgttct 47820 ggatttaatc gacgtagctt acaccatata cgcctgactg tggaatttgg agcgacctag 47880 gagaattgaa ctcctatctt ctgattggaa gtcagaaata atacccgcta taccaaggcc 47940 gcttaaattt gttctacatc tgtgatttga cccaaataaa atgaaattct atattctata 48000 aattcattat tatggtacga aattaaatcc aattcaccac tatattctaa aatattattt 48060 ttgaaatgta aatggttttt gtcaatagta aattcattaa aatttggttc taaatctttt 48120 gtttgaaatt ctaaaccatt atgttcttgt ttaaaatttt tatgtttaat tgatttaaca 48180 ctaattgtat cgtatacacc cataataata tcctcatgtt atcaaatgaa tatccactca 48240 taagttttat ataacttatg tcacgtctgg tccagaaaat cgaatttcga ataatccgga 48300 accgattaat cggaacgtct aagtggatat tgatttggtc tgtacggaag gattcgaacc 48360 ttcgacatct tctatccaaa agaagtagcc taccagactg cgctacgtac agttatcttt 48420 tagtactcca atttttatca gtagctttat ctactgcttt agaataccaa tttttaatat 48480 cttttgacac agaataacca gttaatatgt ttgcaattga aatactataa aaagccatta 48540 gtaatatgca tgacacaaat cctaatataa cacaaataat tcctaaagca ctcatattat 48600 cctcacaatt aatttggtga cccaccatgg aatcgaacca tgctccaacg cttatgaggc 48660 gttcgctttc aaccagtaag ctagaggggc caaatttggt ggtaccgggt agactcgaac 48720 taccgaaggc cgaagcctgg agatttacag tctcctgtca ttgccgctag actacgatac 48780 caataaaatg gtacacacta caggattcga acctgtgacc tagggcttag aaggtccttg 48840 ctctatccaa ctgagctaag tgtgcattat taataaattc tagtttaaaa cttattaata 48900 atggcaggat atcctgccta aacttaaact ctgtacttat ttataatatc taaaacagtg 48960 gattcgtttt ccttcaattc caagtagatg ttatctctaa cttcagtatc actgatatgc 49020 cacttcatag catctatcaa taaatctctt gggatcatat taaacaattc atttaataaa 49080 gcaacattat tttctaattc tatatcaaat aattcaaaaa tagaatcatg cacagaatta 49140 taaaaatcag tatactctat atcatacttt gataagtttt caataaaatt aatcatatta 49200 tgctcacaat aattggtagg acgtactggg atcgaaccag tgacattcgg gttaaaagtc 49260 cgatgctcta ccaactgagc taacgtccta gatgtgcgta ctatcaggtg tgttaattta 49320 tacgcagctt taattaaaaa tataggtacc taagcaatct atatccacct aattattatc 49380 tggcatttaa tttaaatgat agaacatatt cctctaccac acatgtatta tcctgctctc 49440 aggctagacg attaccatcg ttagcgtata atccatattt ctacgttcca gttattatac 49500 gactttaaat atttgatatt gtacctcatt cgtagggcga catttcgctc ttgtttccaa 49560 gaccaacgag gagttagacc ataatgccta gtatctaaaa ctaataaaga cctaggttcc 49620 tcttgtttac aatatcataa tatttaattt ggcgggcagt gtaggaatcg aacctacgta 49680 aaacagatta acagtccgcc gcttaaacca ttcagccaac tacccaatat atttagcatt 49740 cttatgataa gattctatta taccccaacc cgattctaaa cccaagaaaa tgaaaataag 49800 gtttatttac ataattcagg atatgaccgt ttaaacttgc tgttagaaag caaagccttt 49860 accaatttgt caccaaatct tttcttgaca ctttccccag attcgtcata atctagttta 49920 atgtttttca atattctttc accacccgta aaggtcattt tagcttcata ccccttcttg 49980 ggatcatagt ttatgaaatc taatgtcact ttgacactga gtcctttatt cgcgtcatgg 50040 ttaataaaaa tttgttttct gttatcatcc agaactggaa acaaaatcac atattggttg 50100 cgtgaatatg ttttttctat tttatattct ggtaaagcag attctgtgag aacactttca 50160 gtgataaatt ctttaaatga cttcatttct catcctatta ttttgataaa tcgttaccaa 50220 cgtatctttc cagcccgacc ttcagcaaga cgaactcacg taaaacagat taacagtccg 50280 ccgcttaaac cattcagcca actacccaat atatttagca ttcttatgat aagattctat 50340 tatacccaat tcagaagtat acattgaaat agttttacca tttgtgaact ctataactat 50400 atttataaca taaatagagg tggtattttc gtcagaatta ataatattct tcacttgttg 50460 gtagaagaat atattatcac atatattatg aaagcatatc accgaacttc taaatcagga 50520 ataaccactg taggtttaaa aataacttta taatgataag gggcttgctt tggcactgtc 50580 gacttgttca ataaagaaag ttacattatc agaaagtcca agcatatgtt ttttatattc 50640 attaggtcct gtttgacaga caataccaag aacacgatct gtacttgtat tatcacgggt 50700 gcacttacct tctatttgaa gcatataatc attagtgata ccattataaa atacaatacg 50760 gcgttcaatt ttaaaattat cagaatcttt actcagatta cgtgatacaa catctgaatc 50820 atttgggcac ccagttaata aaaatacagc acctaatact acacatgata atagtttttt 50880 cattgataaa cccttttcgt ttttcttact aaaataactt ggtgaggagt attcataata 50940 taagcaaata catctttatc ataatcacgt gggtggtaat actcatagac cgctacacga 51000 aatccttctt tagtaaatcc taagatgaca ccaatgctaa tgcctttcca gggtcctgta 51060 gatgagaacg agacaatatc tcctacagat attaaattac ctatcatgtc ttctttaggt 51120 gttccctgca ttaatttagg gtgaatttct aattctgggt cattggcata aatttcttta 51180 aacccaattt tattttgttc tttaaataaa ctaaatgctt cattaatatt catttcttat 51240 ctcttcaaaa aattcatcaa ttgaccagtg gtatttttta tgggttttag aaaaacaaat 51300 acaccattgg cttctatttt ggtgtaatca gattcattta cataattaga tatggcacaa 51360 acaaaaatta aagccttcta tactatcaca ccagccatta gaattgaacg cgctattttc 51420 ataacgaata gtatccatta ggattctcca ctactgctga ccaagggctt ttgcgattac 51480 agtgtcaacg atgcctaaat cgtcttcatc atctggttta tagcttgcaa ttttattgcg 51540 aagtcttatt aactgctcta ataactctgg tgctgctgcg attaaatacg tattagctct 51600 agcctgctct gtccctattg ctttttgtag agtatgtgct attgatttat cgccactttt 51660 tattaatccg ctaggtaagt cgaaatcagt gtttataact gcaacccacg gcgctcgact 51720 atgcttaaat tccatatcac cccctggcct ttaacattgc atcggcatat gcataagcaa 51780 gtttcgcata atattcagtg gcctctttaa ccgaagtaaa agcaacgtta ctcgtatcac 51840 tatgagataa gcatccgttc agcgcggcta ttgcgaactt gtcacgtaac tcttctaatt 51900 ctgatgataa tagtttatcc gccatacttt ctccattata tcaataaaat ctaaacaata 51960 taaatccgca attaaacggg ttttgactta attagattaa tataactcat cgtcctttga 52020 agcattattt gctaacgtcc atataaactt tataagcaaa ttctgtttct ttagacgtaa 52080 attcatcaga tctagatgat ctagctactt tcataccgta tttttcggca taagatgcaa 52140 attcggatct atctttaaat cgtaggccat ttgtaaaatc tttatataat tggtgcataa 52200 aggccgaaaa tttatttaag aaatcaaatt ttcctttaac aggaccgaca actaaattag 52260 ttccggaaat agctttaact ttgatatatc tcgtatattt agaaatagca tccgcgaacg 52320 gtcctttaat ttcttttgcc caaatagacc gattaaactg gaatgtccaa ttaccgactt 52380 ttatatcgtt tgcaatatat tcgtaacccc aatctttata gtcttttaat ttcatgttat 52440 taaacaagct ttgatcataa tcccgtttat taggattttc ttcaatcatt tctctagtta 52500 atacaggctt tttagattca ttcaaaaatt catcaaatgt tttcattttt ttattcctaa 52560 tttcgattta ggagtatcat atcatcctaa atcgaatgtg taaactatta ttttaaatat 52620 tcgaccattt tatctaccat atcatcatct ctgacattaa acaaataatc tacttctttg 52680 ctatttttca gtatttgcca ttcacctgca cgatgtcgaa caaaagtata tgctcctgat 52740 ttgaatgaat cactactaat ttttttgaca tgttttatct taaggccttc aacctcggct 52800 catgccacaa tttgttgggc tggggttaat ccataatttt tacgcttaac ttctgttatg 52860 aattcattaa atgttttcat ttttcaatta ttcctctttg gtggtttaaa catactatct 52920 tcttaaatta cgtatgtaaa ctataatttg tctgtccaat ccaaatcaag tggttctgta 52980 tattcgtaat ctaaaatgat aggaacatca aatgtacctt caattttaag ttctccaata 53040 tcatagctca atgttatatg tggagaataa tccggaaagt catgagtacc accaatagca 53100 ataccataat tatgtctata agtgagataa tctgatgtat acttaaaaac taaagcagat 53160 ttacctgact cagttttcca tgtatctaaa gttccatgat ctgctaattt aaaactgcct 53220 gaactaggaa cataaggaac gtttacccta gaatataaaa tagtactatg caatttttct 53280 ctaggaacag gaaacgggac ctttaaatcc cgttgtaatt gttcgattgc atctagtgtt 53340 aatcctgaga acttggcacc gacatatgtg cctttattag gaatcacttc caactgttcc 53400 tgatgcagta ttatcttcat caacaggctt agctggtttt aaagcttcaa tagcatcata 53460 aatatcttga attttaacct gtccttcttg ttcgatttct aataaagaaa ttacattaga 53520 aataatagtt tgaagttttt cttgttcttg cattaattca cgaactttgt cttctgcgtc 53580 aaatgtacgg attttaagaa cattaacttg gacttgtaaa ttttctaatt cagagttttg 53640 agtattcatt ttttaccttt ttataaaaat cgtctaaaga actattattt tcaataacaa 53700 tatcaccttc taaaatttgg aggtcttgct cggtgatatg attatcattt gtatttgtgt 53760 ttttcttaat atggataact tttccattat gtgatctgat tgcttctatt tcatgtatct 53820 gtcgacaatc agtaataaca attgtatggg acttagggat tcttttatta atataattaa 53880 atactatatc cacccaatac attttatcca tgcttacaac aatgtcagtt ccaagggtct 53940 gtaggaactt tctaattgta aattcattat tatttataat aggaatttta ggaatatcgc 54000 ctttaagtcc atttcttttt aaatgggcaa cacatctcaa catataatct tcaaattggt 54060 cttgtgtcat atctaattta aattcacggt caataccgtg accatcaaaa tctttataag 54120 acaaattaac gtcattataa ttttgccaat ttatagacaa tgtaaatttt aaataatcag 54180 caaaggctat tttgtgacaa tatctatttt gttcatcaca taatgattca atataatttg 54240 cacatgtatc tttaccactt ctttttttgc cagtcaatcc tataatcatt tattacctca 54300 tagatggatg taaatttctt ccaatagaaa ttgctgaatc ttggatagac ggacgagata 54360 ctattatttt gttatctttt tcaatttcaa aatatttaaa attaaaatta acggtcatat 54420 aaacagctgg atctccttct gtatcatatc catattctat atcagaaata gaagaaggcc 54480 aagctccata ataattaaaa gatactaatg atttcttttt atcattatct agtatatgta 54540 atatgatacc ttcaggttgt ccagaaacat cccaggcact attattatga gtaatatagt 54600 tatttattga taacatccat ttgtatatct cgatgtacga gaggagctcc tcatctaata 54660 atactttagc tattaattca ccatgttcta atgtagatcc aggtaaattt gatcttccaa 54720 gtcctttcgt tcctaaagga acttctgtaa taggtattct aacatctgga aggataaagc 54780 tttgaacatt tagagtaaaa gcttctgtta atttactatc tggtatatct attctaaagt 54840 tagtagaatt agtttgatta aaaaaactca ttatagtttc cttagtttat tattttatta 54900 aaagtataat atattctata taactattaa gtaataaatt aataactcta tgttattatt 54960 aaaaatatta aaatctggag ctgcgctcca gaaaatagtt tcttctagtt attattttat 55020 taaaagtata gtatattcta tataactatt aagtaataaa ttaataactc tatgttatta 55080 tcttttccag actttagaag cagcaaatct tgaaccttga gacataaatt gttgagtagg 55140 cataaaaata atattagacc agtcttgagg cttaacttct attataggtc ctttaatatg 55200 tccaggtaaa taagctttta tcatttgatc tgagccatgc attcctctaa cattactcca 55260 atttattttt agctttgttt tagaagaaat gttacttgta gaagaaaatc tttttaataa 55320 ttcttctaaa aatgcttgtc tggctttagg tggtatataa tggaggttta aaccatacat 55380 caattgatta ccattacctg ctgttttcgc acctaagaat ataattaaag gaaacttatc 55440 ccaatacggg agagtatctt tatttttggc atcataaaca taagtataaa tcttaccaat 55500 ttctggtgtt ttagtagttc ttgttctaac accagtttta atagtttctt taaaccactt 55560 tatagattta ttgtttactg ctgcaccttc gtttcttatt tttttcttta aagtacttct 55620 aaactcatta actattgcaa gttcgcgttc tcttcttgtt aaattatgtt tagatttacc 55680 tttaatggct tcaacttcta aagcttcttt tattttatct gaatacctgc tcattgcaga 55740 agtaaaagtg ctatatttta ttcctttatg ttctgcaaac tttttagaag atatacttcg 55800 tctcacttta gaaaattcaa cacctaattt aatccagtct tgggccgatt taggtaatgt 55860 tttttcttct tcaatttcaa atatcatcct ttccacccca ttgtctttaa tgacctttca 55920 gtcactatct taaattgtaa attcatttta tccgctaatt ttttagcagc tttccattta 55980 tcagaattaa cttgatatgt atacatttct tccataaatc gtttctttgc tttaactgtg 56040 acattagcag gtggtcttgg tggttgggtt tctttaaatg gtttaacttc aaaaaggaat 56100 tcttggccac ttttaaactt agcccagaaa tccataaaat atcttctttt tttaccatct 56160 gcattactaa aatacggaat tatgacagtt tcagaactcc aagacacaac atcagaatta 56220 ttatcaagcc atttcataaa aaaatgttcc caagatgatc tataagttat ttttcgccaa 56280 tcccctttat atttgtcttt atttactggc aaaaacttac ctttatatgc cataataggt 56340 cctctttata aatacatata taatatttat aacaggcggg ggtaaaatga tattttcctt 56400 ttttgatccg gttgaatata gaggtaaacc tacaacaaat atattcaaaa attataaagt 56460 atacataaaa agagttcttt ctaattacaa attaaaaaca tattacataa agggttctcc 56520 tagacctgaa gaattagcaa atacattata tggcaatcca caattatatt gggttctttt 56580 aatgataaat gataattatg acccatttca tggttggata aaaggacaag aggcttctta 56640 tcaaagcgct atacaacgct acgagaacgc aggtgggcaa caagttctgt accatataga 56700 taacaatggc gaaagatatt ataaccttgt agaagaccct gataaccctg gtttatggta 56760 cgataaaggc gataaagaaa tggagtatct acaatataac gggcctttag ccgctgtaga 56820 tattttagaa gatgccattc taagaaatga agaatcacgc gaaataaaaa taattgaccc 56880 aaaagaaata caatcattta ttagtgcaat tattagagaa atggaaaaat cattatgaat 56940 atacaaaata cttatcttca accatttttt ggtgttgttg aagatcgtat ggacccaaaa 57000 aaattaggac gcgttagagt acgtatatat ggtgatcacc cattttcaaa aacaaaaggt 57060 gacgtagctg ggttagaaac tgaagatctt ttatggttcc aagttctttt accggcaaca 57120 tctgcaacag aatctggtgt tggtaattct ccaactggta ttttagaagg ttcctcagtt 57180 tttggattat atttagacaa atataaaact tctggtattg tattagggac ctgggctggt 57240 attagaacag aaatgcctaa ttacactgaa ggcttttcag acccaaatca acagtaccct 57300 actaaacttg ggaatgattt aaatgattta tctctaggtg gaagaatagg taaagaatct 57360 attgttaacg taattcaaaa tgataataga gaaactgcgc cgaacccatc aaatattccg 57420 gctggcgaag aaccagaaaa taacagccca gaattgacaa tagaaaaaat gttacaacgt 57480 gacgaaggct tgcgtttaag atggtaccca gataatggat acgcaagtat aggtattgga 57540 catttaataa aagcccaaaa aacatcagat cctgatttaa ttaataaatg gatatcagaa 57600 ctagttggaa gaaaggttac taatggcaca atcactatgg acgagtgtat ggctattttt 57660 aaatctgata ttaaaaaagt taaagatggg atagttaaac accctactat tggtccaatt 57720 tacaaaaaat gtaatgcttc aagaaaaatg gctttggaaa atatggctta tcaaatgggc 57780 cttggtggat tagccaaatt taagaaaact ctaaaataca tggaagaaga gaaatgggaa 57840 gatgcttata taaatcttca acaatctttg tggtttagac aaacaaaagg acgagcgtca 57900 agggtttctt tgattattcg taatggtaat ttagaatcat atggtgagaa gacgcctagt 57960 aatgccaggg cattatcatc acaaaggaat ataaacatag agcctgaaga tccttatgtc 58020 cctaacgata cccgagtgat gtttgaagaa ccaaaaacag agtataacag ccaatatccg 58080 tataataaaa cttttggtac tgagtctggg atgattcaag aatttgacga tacacctggt 58140 gccgaacgat atagattaac ccatacttcc gggacatacc aagaaatttc tccagatgga 58200 agaaatgttc agaaaataat aggtgataat tataaaattg ttcaacaaga tgaccatata 58260 cttgttcaag gtgatgttaa attagttatt ggcggtaatt ctaatgttta tataatggga 58320 actttaaacc aaaccataga tggaagtgtt aatcagacag ttcgtggtaa tgtggtccaa 58380 catgtcgaag gaaatgtcaa agcaacaata gatcaaacag ccgatattct tgtaaaagaa 58440 gaagccatgc ttactgtaga aaaagatgtt accataaatg ctaatcaaaa tgcagaaata 58500 aatgttaaag agcaagcaac agttaatgca gaaaatattt ctgttaacgc agaaaagaaa 58560 atggaattta aagccgaaga tgttgatttt agcgcagtaa aaacattttc tgttgattct 58620 ggggttctta ccaaaattac tggtgctaat gtacaggtgg gataatgaat tattacgata 58680 aaatagatga agttgtctca aactttgttc atccatgtga aggagaagtg ccagatgggt 58740 tctatagacg cgttaagtgg gaactatata atccatcaaa agaaaacaaa ggcccaggaa 58800 atggcgaaga gtgggatact gagataatta aaatagggac tagattatat gacgcgaacc 58860 catttgggca taaatcagaa gaattcccgg aaccttctgt agaaggagaa gatgaagaaa 58920 aatgcaaatt ttggtctaaa aaaataggaa tatgcttcaa atcccaacaa gagcttactg 58980 attatgtaga atctataggg tctaaattat taccaggcaa tgattggtac ggagcagatt 59040 tatctaaatc aaatctgttt aaaacaccac atgaatacaa aatgtaccaa atagaaaacg 59100 ctggtggcac ttggtctaaa acaggccctt ctattgataa aagaaccatg ttgatggtag 59160 acaaggatta taatatttct atcaattata atggcgttta tgattcaaga tctgcttatt 59220 tgaaacatta tgaagacaaa ccatgtacat atgttggtat aagattaaac cttgatgtag 59280 atttaagtgt accaggaata cctgaatctg aaccaccaaa aattggagat cttcctgctg 59340 aactcccgtc tttaatattt gcagcaagaa gtttacctgc aattggatgt attccattta 59400 aagctaaatt tccgtataat ggattatcac aagcaatagt tgaagcatgg aatgaatcta 59460 gaagatcttt taaattaatg tgggcagata ttcctggctt acctgaaggc gaaggttcta 59520 tctggagtac catgtattct ggtgtgtcta ttgctatgga agaattagga aatgcttcac 59580 taagtatgtg ccaatacgtt caacaaatgg cttggctaac atttaaagaa gttatttcac 59640 aagcattaaa cattgttggt gcaggatggg atttattaaa atcatttatt cctaaagtaa 59700 ctattcttgg gataactttt gacatagaag atatatgtac ttctggtaat gggttacaaa 59760 aattaaaaga agctttttct aaatttgata tagaaaaagt aatagaagga atatatgcat 59820 ttataggaag tgcctacgaa tattctgtag agtatgtgaa ggtattttca agagacttaa 59880 tagatgcttt aacggattta tacgactatt tgtggtatgt tttaatgacc gctggtgtag 59940 ctttatgcaa aacccttgtt aatttagcag aaatttggtc cattccacca tggattccaa 60000 acccattatg gaatgttgtg attgcagtaa aagaactaat gaaacaaata gaaccattag 60060 atatgattct taaaggtgga tttcctggat ttactgcttc agatttatat tacatggtag 60120 aacgaaaagt caaagaactt attgatgaag catacaccaa aatagaatct ttaaaaaatc 60180 aagccattaa attatgggaa caagtaaaag aggccaaaga taagtggcaa aaagaatcta 60240 taggatttaa acaatacctt aaaggcatgt atggcgctgt cagtgaagaa cttactcgtc 60300 aaaaagaagc tttagtacaa gaagcaaaag atatatacga aaatttatta gctaaatatg 60360 aagcattaaa tataaatata gacacactta aaacttctgt ttctaatgta cttgaattag 60420 cattaaatga attaagaaat cttcctatag ttgaccaaat agaacaatta ttatcattag 60480 taggaacttc atttgatgag atgataacca ctattaaaaa tagtataact ggtgctcaat 60540 cattatataa aaactttaca gatggaagtc gatcactaaa agatatatgt aaatatatct 60600 tcagtcaaat ttctacatta tctttgagta aagttactca atggattaat aaattattga 60660 gtatattcgg tttagaaatt aaatttcctg aattagaact gtgtatacca tacgtaaaat 60720 acgaggaata aaatggattt aattaaaaaa caaataaaca gtattcctga agtatacact 60780 tcagccactt ttgacgagat aaaagcagat tggattaatt ggcttagagg ccaagacgaa 60840 tttaaagact atgattttaa aggctctaga ttaaatattt tattagatct tttaacatat 60900 aatgtgttat atatccaaca atttagtaat tcagccttat atgaatcatt tatacgaact 60960 gcttcattaa ggtcttcagt tgtacaagct gctcaagata tggggtattt tccatcatct 61020 atgactgcgg cagaatgttc tatcatgtta gaatgtacac ataaattaaa tccacaaagt 61080 attaaaattc ctagaggaac caaattttta gcatcatcta aagatggtcc aacacaacca 61140 tataattttg tagttaaaga agatgttaat gttgttaaga gtaaagatgg taaatattat 61200 ccaataatta atttagttca aggacgagtt gttagaactg aattagaata tgacccagat 61260 caacaaattc ttattcgcga taaatttatg gatagacaca ctgttagagt tatggttaac 61320 ggtgtaaaat gggaagattg gacagaaaaa tctattgtta atatttcagg aacaagtcat 61380 gtattctata tgagagaaac aatagatgaa tatacagaga tattttttgg tgaaggtcaa 61440 tctgattatt ctgttgtgga tggaagctta caaagccact atattggtgg attaaaaccc 61500 gttgctggga gcaatattgt aatagagtat attagaactg atggtggaaa agctaatggg 61560 tctattaact ttagttatgc tgatacactt cagtatgttt ctgtagtcaa tattatagaa 61620 aactatgatg aatctgctga ctatatcgga gcctttggtg gtggtgaccc tgaagatata 61680 gaaagaataa gagagcttgg accaattaaa agagaatcac aaagacgatg tgtaactgca 61740 acagactatg aatcatttat ttctgaacga tttggtccaa ttgtccaagc aatacagtgt 61800 tttacagata gagataaacc aggttatgca tttatagcaa ttaaacctaa agaaggatta 61860 agattatcat ctgtacaacg tgaagatatc caaaattatc ttaaagaata taatatttct 61920 actattacac caagtgtaat gtcacctaat tatatgttct taaaacataa agttaaagtg 61980 acgtattcta tgaataaact ttctgaatca gaacaatggt taaaagggca aatcatagat 62040 caaatagata aatattataa agatgaagta gaaatattta ataaaagttt tcacaaatct 62100 aaaatgttaa cttatgttga tgatgcagat atttctattt taggttcttc tgcagaaata 62160 actatggtca gagaattaga aaatttcttt aagactccaa tggctggtgt caaatataat 62220 aataaaatac ttccaaaggg cctattgagc aatgtatttg aatacactgt taatgatgat 62280 ttgtcttatg gagttagatt agcttcgaca gaacctaaag gtgatttaaa agaaggtaaa 62340 attgttatag gaccatttag acaaggcgac atcaaaatta gcccttatct tggaactgat 62400 tttgaaaaat taaaaacatc tgacaatcgt aatagttatt ttgttgttgg taaaatcatt 62460 catgaagaag attatattta ttgggatctt ggacaattaa atgtcacaag tgataaattt 62520 ttagttccaa gtatagaatt atatggaact ccaggagatt ctaatatctt tacaaaagat 62580 gggtcactta ttgtgtttga aaataattta agacccgaat acacagaaat tattatggag 62640 cctatagctt aatgaaagca cctaaagtta ctagtctaag aataataaaa ttatctgcta 62700 accaggttca tattaaatgg gaccctgtag gtagtaattt ttattatttt gtggaactag 62760 cagaatcaag aaacgacgga acgaaagttc cgttagataa actacaatgg cagaatctag 62820 ggtatagttc tgataatgat agattcatta gtattggaat aatccctaat acacattatt 62880 tgattagagt atctgttaga gcaaaggggt ttgaacaatc agattgggca tatacagaag 62940 aatttttgac atttaaatca aacgcatatt cttttgacca tatgaaagaa tttactttat 63000 ctgaacaatt tattaaagaa aaatttgtta aaaataactc aaactatatt aattttaata 63060 ctgaccaatt gttagcctct ttaatgacag aagattttca attcacatcc aaatataatg 63120 atgtatctca aatttctaat aaaatattaa aagaagctaa ttttcatgag atacaaggaa 63180 cacctgaagg aataactaga gtttgttctg atatcaatag agttatgcct gcagaaatgg 63240 atggagtttt atatctattt gaaaggttcc aaaatgttgt taaagtttct aatgataaag 63300 ggcagacatg gaagtattat aaagccctag atgaccgtgt gggtaatcct gtttctaaaa 63360 catgtatata tcaatcagat actacttcat acgttctagg ctatgatagg gtgttttatg 63420 gccgaagaag ttctgatgtt agatggtcca acgatcaaca tcgtttttct gaaacagatt 63480 taacattttc aaaaatagga gatactttac atttagggtt tgatgtcgag gtttttggca 63540 cattatcatt tttacccggt aacgtatcca gatttgctga agcaattgca tccaataatg 63600 attttttata tgttgccgcg ctaaaaataa tttaagattt ttagaccttc acaatgcaga 63660 tgtagatatg gatgaaggtt ctatatcata cggtaaaaaa ttatttgatg aaaagactat 63720 aaaaataaca gataatgaaa atatcgttgt taaaaaaatg gatgttctta atggagaact 63780 ttatatttta gtcacgggtg aagtcaagaa atattttatg gacccaacta aacatgaaaa 63840 tgttatagat tctaaagata aaggcgtata taaattagta gatgacaagc tggttcgtgt 63900 ttttggtaat actgaagaag aacgtagaaa aatagaacac gaatacacta atatgtcaac 63960 tgatggtaaa gaaatcttta ttagttatgc taattttaaa tataccgaat acacaaaaga 64020 cgataaacta gaaaatggca tcaaatacat aaaaactgaa agtggacttt cagataaaca 64080 ttatcacatg ggttctatta gaacttcaga cggtgaaaca tggaaaccat attatatgag 64140 ttattacgct gagccatggt ttacttggat gaatagaaca aaaactcgtg tatggattaa 64200 taatgataat cggcctgtag tggtatatcc ttcaaaaatc tatacaaaga taatagatac 64260 tgtaggtcca actggtgaag atcgtgtagt taaggaagtt tgggataaag gccatggaac 64320 attttattgt aaaaatatat tttttgaagg atttaaacaa tattcaggtg gtgtattaat 64380 ccataaaagt tcaggtgaaa tagtaggata ttatgaatat aattatcgtg ttagagataa 64440 tgcccaaatc atatggattc caaaattaat atgtttacag gctactttac aaaaccaaga 64500 acacccagaa atatgggaac ctaaacataa taaaggcgaa aaagatcctg atttaagacc 64560 tttactaaat acgatgattc ctgatagtta cttattacaa aatagtaatt ttgaaaagtt 64620 ctgtgaatat tacctccaat ttttatctga tggtaaaaac acacattata ataaattact 64680 taatttaatt agaaacaaat atcctagaga aacagattca gtagagtatt tgtggtcaga 64740 aattaacaaa agaaacattt atttagataa agataaaaga gatcaagtaa tacggttttt 64800 tgaatcaaga aaatctgatt tttatagcac aaaaggaacc gaagccagtt ataaattctt 64860 gtttaaactt ttatataatg aagatgttga aatagaaata gaatctaatt ctgggttaga 64920 atatgatatt gtagtttatt ctgataatat caatgaagac atcgtcggac gaacaatata 64980 cactcctacc ggccgttgta atgtcacata tattgaaaga gaatatgcca aaggaaaatt 65040 acaatggcgt atgactattc ataatatgat tgggcgtttt ttagtaggtc aaaatattct 65100 aggcgaaaga agtgatttta aaggacaaat aatccaaggg attaaaggta aagaaatatt 65160 atctaataaa gaagatcttg ctaataggtc tagaagttat tatgtaatga aaataaagtc 65220 taaacttcca acatcaagat attcttctga tgtgttaaga tttgttcatc cagttgggtt 65280 tggttttatt ggaataacat tattaacaat gtttataaat tcaggattgt cccttaaaca 65340 ttctgaaact attatcaata aactgattac atataggtat gattctgggt atccttctat 65400 atggcctgat agagttgcta tattaaaaaa tgatattata gagcgtgacc ctataacagg 65460 agaagcgtta tacacattac atcctaaagc cggtgaagat tttgatattc ctgatgatta 65520 tgacaaaaat gaaggcttta taggaccaga aaaaccatat acaaatatgg aagagtattt 65580 aaaaaatgtt ccaccttcta agagaagaca taagtatagt cctttatttg atcagtctgg 65640 attaacatat tctattttta gagatatgac aaatctactc atccaaagtg ataaatatag 65700 atataaagat aatattaaca atccaaggga ccctgaaaag ccttcacagg agaaagtata 65760 atggattcag tagaattgta tagatcggtt gttacatcta aatttagaac cggtaaatta 65820 ttaagttttt atgactctat aggtgattct gattctaaaa ccacaattta tgttggattt 65880 ggacgacaag aaccatgggc cgaaaacgaa aaagaggtgg gttttgcccc gccttatcca 65940 atagatgatg tatcaggtgt ttctgacatg tggacgcata tgataggttt aatgaaagtt 66000 gacaagagtt tagttgatgc cttgattcca cgacgggatt ggggtgattc aagataccca 66060 aacccgagaa catttaatat tggtgatatc gtagttacaa actcggctcc ttataaccaa 66120 acagatattg gtgatggatg gaaagtttat agagtagtag atattcctaa aactggtgtt 66180 tgttctataa gtaatattaa gaataaagac gagtgtatta aattaggtgg gacttggaca 66240 ccatcatatg aatctgtttt tccaccaaaa ggaagaggag atgcagaaaa aggtggatta 66300 gttgatatgg aagatggata tttatgggaa tatttatata ctattccacc tgatgtatca 66360 attaatagat gtactaacga atatattgtt gtccctacac cagatgaatt aggggaagat 66420 ctagaacgtt ggggatacga agataattta tcatggcaac aaaatgataa taatttagtg 66480 tatagactta aagttgtgac tttacgtttt agagctttta tggactctgt ttattttcca 66540 gaagcttctt ggcctggaaa taacgggttt agacaaatat gtgttgttat aaatccatta 66600 gaaaagaaac aatggcctaa tgacccaaat ataaaagcaa ctaaaaacta ttatcgtgta 66660 tctcaagtag aacgcaattc tggtgaaatg atatatctag aaaacagacc accatataac 66720 aagatctata gaccaaacag aactggtgga tttggttttt agtttttaaa ttaaggagcc 66780 tagtgctcct tttttgtata aataaggata tataacgagg gctcaatatg caagaatata 66840 aaacacttat tgacactggt attaaaggaa attcttcaac aggggatatt ctatacgatg 66900 gcggtgaaaa attaaatatc aatatgaaca atatctataa tacttttggc gattatagat 66960 tatttgatga aacacttcaa ggccaaggaa aacagaaact ccatggaaca gggtattatc 67020 aaaaacatac aagaatgtat tatttagata cccctgaagg agtagaaatg gggtctttgc 67080 acgatgttga cactagtaca ggcaaacttg atataaaact tcctgctgct aagcttggtg 67140 aaggtatcgt tattataaac agcaatgggt ctctaagtaa agacacccca gttattttat 67200 ctacatttgg ttcagatact attgctggac atggtgctag attatcttta gaaatgccaa 67260 aaaaccaaaa caacactatg gtgtacacgt caagaccaag gtatcggcgt atgggaatat 67320 agaatagaat ccatgtttgg taatcatcaa ctagccgttg attctgattt gatgttagac 67380 actacagaaa aaactataga aattggtaac gtagaccact ataacactat aaaattactt 67440 cttcatggtg tatctcaaaa ccaaaagtcg tttaaaagct cagaaatgtt gatatctatt 67500 ttacattctt caggcgaagt ttataaaaca gaatacgcag ttttaaaaaa taatggagat 67560 ctattttcaa tagattttgt tatagaatct ggtattttaa aagccaaagt aaaatcatta 67620 tcaggaaacg ttgcgttttc tattaaatct attgggtcta ttaaggtagg agccgtatga 67680 tacaagtaat aaacattggt aataccgtag atgacggaac tggcgactat ttacgtaaag 67740 gtggccaaaa aaacaaatga aaactttaaa gaaatatacc atgaattagg tgatgataaa 67800 atattacatt ccgccggtgc ttggaaaaca tatactgcta aatctggagc attaacacca 67860 caatttggtc aatcattagc acttaatacg ttagaaggcc cctataaatg taacattgcc 67920 taaagggtca gtagaagatt ataacaaagt tattagaatc cgagacgttt ggaattcttg 67980 ggaaaagtct cctgttaacg tgattgcatc taaaggtgat actataaaag gatcttcggg 68040 ttctaagaaa tttgacaaga acttaatgga cttagaatta gtgtattgtg ctcctgggcg 68100 atgggaatat gttgaaaata aacgtgtaga cagattaact aatcctaata tgtctactgt 68160 aattaaacga agtattattg ctaaacaagg gcaaaaagat tttttagata tttttaatgg 68220 taatctatat aatacacgaa actttgatgt atatcgtcgt ggtaatattt tatattacgg 68280 tgataattct tttgataaag ctaatgccga ttatggttct ccagatgggg cttctaatat 68340 taaagcactt gatggcaaaa acgttagatt aaaagatgca tgtgaagctg gtgatgtaat 68400 tacatttatt tcatttttag atggggttga ttcttggaaa agttcatata atagaaaaac 68460 cgtgacatta gttgataaaa ctttatcttc tgaaacaact atcccaggaa gattaatttc 68520 tgtagacttt acaaaatggc cattagaaat ttcgatgaac gacttcggat tttttgatgg 68580 agaatctgcg aatccatatg cattagaagt tttagttaat ggggttcaat atactcaatt 68640 aaatgatgca aacacccagt ctatgtctgg tgactatgaa tttaaaatga caaatggaaa 68700 aatagaggct attgtattcc attcaagatt aaatcataac gataatatag ttttacgatg 68760 gtttaataac gatataggta caactcttcc tatagaagaa ataacatcta taacggacca 68820 aatgtacgtt gcatcagaaa cactcaaagt ttcaaataga atagcatata ctgatacaga 68880 taatccatct caaaaaacaa aaataaaagt tgatgatgat ggagattata aagttaataa 68940 tgtatctaaa atatttgatt tattctatcc aattggaact atatatgaaa atgcccataa 69000 tgctgctaat cctgcgacat atatgggtat aggtacttgg gttagatacg ctgaaggtat 69060 gacaactgtc ggttggaatt cagattcaaa tgataaaaac ttccattaca ataattctga 69120 tttaaatgcc caaggtgttc cttctaaaac tgccggtggt aaagttggta aagcttttgt 69180 tgcattagaa aaggctaatc ttcctggaac agaaacaaat gaagatgtat taattaaaga 69240 taaaaatgga actattatca tcggtgggtg ccaatttgat ccagatgatg aaggtcctgg 69300 ctatgacaaa tacagagaag ataaagcaac aacagggact caatctgatt ttggcagaga 69360 atttagttta atacagccat ctataacaac gtataaatgg ataagggtag cataatgaaa 69420 aataataatg tatcacattc atcacctaat tctagtgaaa tttactattc tgtaggtaat 69480 gatactttat ctggtaatag ggttccatta ggaacccaag atacaagaca atcaagttta 69540 aatgtatatc aacctaatgt gcaggcagct ctagatgact ttaagggagc ttttttacca 69600 ttaaatgcat taatctacaa tacagatggt gaaaacccac agggcgcatc tcaagtggat 69660 tttgtagatt ttagtggaac cgttgaagga acaggccctg ttatagttca aatatttggt 69720 attccattac aagttactgg cggaaatact gcatctgaag ttagagaagc atttgaaaat 69780 ctagcccaag acctagtagc taagaatcaa tatttttctt ttgtccaaaa agaatccgaa 69840 acaagattaa cagtaaagta tattgattat agagaccacg atgctataaa tacatatagt 69900 aatggtatta gtgtatcaac agaaattcaa tcacctgcaa aatatggata tgggacatgg 69960 gttaaattag gggttaaaaa cgaaacctta ggagatacag aattaccagt ctacgtattc 70020 aaaaggatag catgatgcaa aatacatata aacatataag tgacagctca tcatttgtca 70080 catttaatcc agtaggaacc caatgggacc aatcaattaa agatgttcaa acagctttat 70140 caaagattgg ttcttgggct atgataggta agggattacc tatttcaaca gaaacattaa 70200 atggtataat tagaaccgcc actagagatg aagttttaaa aggccaaggt tcaggtgcag 70260 taactccaaa atatttagaa gaacgactag ctcatccaca agcaactgaa accgttttag 70320 gattaaccaa atatgctaat aattctgaaa cactagctgg aacccttaat aataaggctg 70380 ttgttccaac tgggttaaag catactttag attccagaac ttcaactgaa ggaagaacag 70440 gtttaattaa aatttcttct ttatcagccg cagcacaagg tgttgatgac acaacggcca 70500 tgacccccta aaaaagtcaa acatgcaatt aatcaattat cgccgtctta tggtatagca 70560 acagaaaaaa atagtggaac tgttaatatt gcttctttag gccaagttgc tcaaggacaa 70620 gcgcatgatg gtatagctgt ttctccaaaa ggatttattt ctactagagc ttctgaatct 70680 caaattggta caacaaaaat agccacagtg gcccaaacaa aggccttgtc tgatgcaaca 70740 ttagtagttt ctcctaaaaa cttaggacaa ttaaaggcat cagagtctga atttggatta 70800 gttaaaacta caacaactat tggtaataca ggggctaatt tagcattaag tccaatggcc 70860 ccagttgttc ctacatctag gacaataaac aataaatcat taacagggaa tattgtttta 70920 aattctgatg acgttggatc atattctaaa tctcaagtat ggactaaatc agaatcagat 70980 gagagatata tgcctaaaac agatattcca aaacagtcat tttatactta ttttgatgct 71040 tggcagttag aaggccaact atcctatagg ccgtggtggg tattgggctg aattaggtaa 71100 aacacgatta ccttttggtg aatatacacg tttacaattt aatatgacca ttaataacac 71160 tagggattta agaccttttg taatgaaaat atataaaaat gatgaagtaa ttaaagaata 71220 ttcaagattc gtgggatatc caaataatta cagttttaca gatagattat taattaatgg 71280 caaatttaaa gctggggatg ttattagggc cgaagccaca gccaatggtg gtcctaatta 71340 ttcgtataat tttaaaacat ggtacctatt attcacataa ggaaatagaa tggataaaat 71400 agaattactt ccactgccat ttgttgacgg cccaattaaa gaccaaacac agatagaatg 71460 gattttaaac aaaaaagaat gtttaaccgg tgcatctaaa tacggtaaat ctgacggggt 71520 ccttaacagg gtcccagctc aattatatga aaatataaaa actctccatg aaaacgatac 71580 attaattaat ggacaagtaa atgaattaat cgattctgtt gacactatta atgaatcatt 71640 agaaatagga aataataaag acttaataaa aactataata gaaactaaag accgtgctga 71700 tatttttgaa agcgttatac aaagtaattc tgacgatata tttgaattag atgaagatat 71760 taaagaattg aaagacgaag ttggagttca taatccagtt gatacagtaa aaagaaccct 71820 tcgtgatgat acgctttgga ttaaaaaaga aataggttct taccctggcc aagacataaa 71880 tggtcaaact tcgcaagaat ctttaggtag tggcatgaaa cgtcgtatta tagatgttgc 71940 tacacaaact gtagataata caaaaagaat aggtgtccta gaaaaaacat gggctgattc 72000 cgatgttggt agtttaacca tagaagttgg taaattaaga gaagaacttg gaaaatcatc 72060 agatcaagaa tatttgtctg tttacaaaag actttctgtt atagaggaca atgtcgacaa 72120 agggtctgaa gttataagcg atattatgac taaaataggc ccaggcaatg tatctgaaac 72180 cgtatctatt aatactcaag aaatatcaaa attgaacgaa gaagttctag ggacatctgg 72240 attaaaaacg agagtttcta gaattgaatc taaattaggc gacgaaacta gcccatttac 72300 tattttatat gatattagta aaaataaaga agggctaaaa gacctaaata ctattgttgg 72360 tgccgataca agttcaggat tacgtggaca agttacatgg atccaatccc aagttggatt 72420 aggagatgaa ccacctgcac ctggtacagt attatctaaa atagatttgt tgactaacag 72480 tactaatgaa cttagtatcg atgttcaaaa tttacagtca gagataggta ataataaaac 72540 cggtataaaa ggaactgtta ttcaattagt caaagctatt gaaggtacag accctgaagg 72600 atcgactgta aaagaaatag gtatccaaaa agcaaccgaa gacatgtatg aagtatatga 72660 caaaggaatg cctcttccac cagaagatgg taaagcttac atttgtagat ataaaacatg 72720 gacacctatt ccaacttctt tgggtgtatt tacggcgaag tatgccaaag ccttagaaga 72780 agggttaaat gatgttgata tatcagaaac tttaattagt aagttgtgtg aacttacaga 72840 cggtaaagta tcagtatttg atagtgggca ttatgaaata gatttcgaat ctcttattcc 72900 aaaagaattt aaagatcgaa aaataaagtt tagtattttt aaaaatgacg aaatgttttt 72960 tgagacaagc gatttaatat caacaaataa ttctaatgtt tttaaagaat caactatagt 73020 tgaaatatca gaaaatgatc aaatccatgt aaaagtggaa tcaacagact ctgatttttc 73080 tgagatatct tttggtatta aattacaaat taaaccatta atataattta aggaccttcg 73140 ggtccttttt ttttggagta aacatggcag gatataatgc gtataaccct aaagaattaa 73200 aagatgttat tttaagaaga ttaggtgcac ctattattaa tatagaagta acagaagacc 73260 agatttatga ttgtattcaa agagccttag aactttatgg cgaatatcat tttgatggcc 73320 ttaataaaac ataccaaaca ttttacgttg gagaagacga aacctataca aatggggtct 73380 ttgatttaca cccatcagtt tttgctgtaa cacaaatagt tagaactaat gtaggttcaa 73440 ttacatctat ggatggcaat gcaacatatc cgtggtttac agatttttta atgggtatgg 73500 ctggtattaa tggtggcatg ggctcttctt gtaataagtt ttatggacca aacgcatttg 73560 gtgctgattt aggatatttt acccaattaa tgcaatatag aagcatgatg caagatatgt 73620 tgaccccaac taccagatta ttggcagaat tcagatacca atcaacttaa agtgatgggt 73680 aattttaagc ccggagatat tataatttgt gaagtttacg ttaaatcata tatagatgtt 73740 cctgataata tgggcgccac ttcaggatat gcctgggcag gtggatgtga agaagaacca 73800 agtatctccg atatatatga taacccatat aaaaaattaa caggctatgt tgctggagat 73860 gattcacaag tccatcaagg gtcttataat aatagatggg taaaagatta ttctactact 73920 ttagttaaag aactaaacgg acaaattttg gctaaacatc aaggaatgca attagcaggc 73980 ggtgttactg tagacgggat tagattaata gaagaagcca gagaagaaaa aagaattcta 74040 agagaagaat tagaattatt agacgggcca gtaggaatat taataggata acttatgtat 74100 gatagcagct tatttgcaaa attagaatca aatgaagggt atcataaaac aaatgaaaca 74160 cagatcctca atccttatgt taacttcatg aaacacggta atacccaaga acttgctgac 74220 gttttagttc aagaaacaat acaaatgaga gggctcgagt tatattacat tccaagagaa 74280 tatgcaaatc tagacctttt atttggcgaa gacccaaatt caaaattcac aaaagcttgg 74340 aaatttgcag catatttaga ttcttttgaa ggatattcag gtgataattc ttttatatct 74400 tcatttgggt atcaagttaa tgaccaagta aaattcatca ttaatccatc tttgtttaaa 74460 catcaggtta atggtaaaga accaattgaa ggggatttaa tttactttcc attggataat 74520 tcgttatttg aaataaattg ggtagaacca tatacaccgt tctaccaagt tggtaaaaat 74580 gcccaaagac aaattgttgc agagaaattt atttattcgg gtgaagagct taacccagaa 74640 cttcaaaaaa accaaggaat agaaatagac gaatttagcg tattagattt agaacccgtt 74700 aagaatttag atggtctggc tgatataaca tctgatgaat attctgaagt taaacaaatt 74760 aataaagaag ctaaagaatt tgtacaacca tattatgttg gaaatggacg tggaacccct 74820 tttgaagact ttgaataaat ataattaaag agaggttaaa atgtttggac attggtataa 74880 cagttcatta agaagatata tagtattaat gggagatttg ttctcccata tttctgttgc 74940 cagaatgaga gacaacaaag taaattatat taaagttcct attacatata aatcaaaaga 75000 acggtttgtc caagtattga ataaatacac gaatccttct tctcaagaaa atattgctaa 75060 agtagaaaca gttctaccac gcatgaattt aaatcttgta gatatgatgt ataactcagg 75120 atataagaca tcccaggcaa atagaaccat gtctagagac aatggaataa ggacatattc 75180 acaatatgcc cctacggctt ttaaaatgat ttttgaatta gggatatata caagaaatca 75240 agatgatatg ttccaaatag tggaacaaat tctcccttat tttcaaccac atttcaacac 75300 cacaataact gaaatgcata ctaaccctat taaacaattt gatagagata taagaattgc 75360 attccagagt gtagctatag atgaaacacc tgatggggat gttaatacaa gaagacatat 75420 agaatggtct attatgtttg aagttaatgg atggatttat ccaccagttg cagatattaa 75480 aggagaaatt aagacggtat atgttaattt ctttaatgag aaagttgaat taaccccctg 75540 aaggtgaatt tgaagactta gaagaatttg aatctgtcga tcaccaggtt gtccctaaag 75600 acgtccagga agcggattgg gatggagaaa gtattactac atattctaga aataaaccca 75660 ttcctgttga tcctgatgca cctaaaccga ggtaattatg agtgaactca atatgaccca 75720 actattagat atttctgatt tgcctggagt tacaggcgaa gaaatcttgg tttatccacc 75780 tcttgaactt aaagaggtgg tttctaatcc tgaaaacaga aatattgatt tagaagaaga 75840 ctacaaacaa acacgccaaa ccctgcatca ccaacaacaa atgataatgg atgcagcaaa 75900 aatattttta gaaacagcca agaatgccga ttctccaaga catatggaag tctttgctac 75960 attgatgtca caagtcacta atagtagcaa agaattactt agaattcata aagaaatgaa 76020 agatatcacc aatgagacaa ccagcactaa aaattcacaa aacgttaata tagaaaatgc 76080 taatattgtt atggcctctc ctactgattt attagaagaa tttggtgatt cttacgagac 76140 aaaagaaaat gcaaaaaatt ctagaccatc ctcttaatga tatcattaag aaccctgata 76200 cattagaaac aaaaatagaa gacgggataa aatttataaa atctcaatgg gatgataaat 76260 ggtatcctga aaagtttagt gattatttaa aaataaacaa aatacgaaaa gttaatatcc 76320 aatcaactaa gcctgaagaa tttaaaacat ttaaagataa agacaataag cgttctagat 76380 atatgggtct tcctaactta aaaagagcca atataaaaac tggttggaca agggagatga 76440 tagaagaatg gaaaaaatgc agggataata tattatattt tgccgaaaaa tattgtgcaa 76500 taacacatat tgactatggt acgatagcag ttcaattgcg tgactatcaa aaagatatgt 76560 tagagattat ggataataat cgtatgacgg tctgcaattt atccaggcag ttaggtaaaa 76620 caacggttgt tgctatattt ttggcccatt ttgtttgttt taataaagat aaatttgtag 76680 gtatacttgc tcacaaaggt tctatgtctg cagaagtatt ggatagaact aaacaggcta 76740 ttgcgttgtt gccggatttc ttacaacctg gtatagttga gtggaataaa gggtcgattg 76800 agcttgacaa tggttctaaa ataggggcgt ttgcttcttc acctgatgct gttcgtggta 76860 actcattcgc tttaatatat attgacgaat gcgcttttat acctaacttc ttggacgcct 76920 ggctagccat tcaacctgtt atttcatcag gtagacgttc taaaattatt ataacaacta 76980 cacctaatgg gttaaatcat ttctatgata tatggactgc cgctgtagaa ggtaaatcag 77040 ggtttgcacc atatactgct atttggaact cggtaaaaga acgtttatat aatagtaagg 77100 atatatttga tgatggatgg gaatggtctg cacaaactat ttcaggatct tctttagaac 77160 aatttaaaca agaacatatg gctgaattcc aaggaacttc aggtacatta atatctggta 77220 tgaagttagc taatttagat tggatagaat tagtcccaga aaataatttc tatcaataca 77280 aggccccaga agaagggcat aaatatatag ctactttaga ttctgcagaa ggacgtggtc 77340 aagactatca tgctttaaat ataattgata taactcaaat gccttatgaa caagttgcag 77400 tatatcacag taatacaact tctcacttaa tattaccaga tattatatta aagtatctta 77460 tagcatataa tgaagcaccg atttatattg aattaaatag tactggtgcg actgttgcaa 77520 aatcattatt aaccgattta gaatatgaaa atattatatg tgattcttat acggatttag 77580 gtgttaaaca aaataaaaga actaaagcca taggttgttc tacattaaaa gatttaatag 77640 aaaaagataa attaattatt caccataaac ctacagtatt tgaattacgg gtgtttagtg 77700 agaaaggggt ttcttgggcc gcagaagaag gttatcatga tgacttagtg atgtcattag 77760 taattttcgc ttggctaaca acccaacaaa aatttactga ttatactgaa aacgatatta 77820 gattagctaa tgaagtgttt aggtctgaat tagaagatat gggtgatgag tatactcctg 77880 ttgtaataat agatgcaggt gaatctacaa cggaatttga ttttagcagc ccgtctatta 77940 ttgggtaata aataatataa acaaatgagg ataaattatg tcatctacat tactttcacc 78000 tggagttgaa tctagggaaa ctagcgtaca atctacgatt gttagaaacg ctacaggaag 78060 agcggctctt gcaggtaaat ttgcatgggg tccggcattc caagttgtac aaattacaaa 78120 tgaagtcgaa ttagtagaca cttttggtgg accaaataac gacactgctg attattttat 78180 cagtgcaatg aactttttac aatacggtaa cgatttacgt attgttcgag ctgttgataa 78240 agaaaatgct aaaaatgcat ctcctttatt tggacaaatt aaatctaaaa tcgtttcagg 78300 tggttctaac tatactgttg gtgataaagt tgttgtaaaa tataacaata aaatcattga 78360 agaagacggt attgttacac aagttgctag tgatactaaa aaaattgaga agatttttat 78420 tccatcagct aaaattattg cacattcaaa agcaattggc acatacccac aattaggtgc 78480 aggatggact gccgaagttt caaaaagtac ttctggtgtt gcaggttcaa tcactttaga 78540 ttctattatt gttgattcag gtattttact aacagaatct gattctgcaa atagtattat 78600 tacttctgaa gaatatatgg aacaaattaa agcttattca ttacctgcta ttgccgctat 78660 ataccccggt gaacgtggtt ctaatataga agtagagatt atttctaaag aatcttatga 78720 aaagaacaca actttaaatc aatacccaga aggtggcgaa aaacaaactt ctggtccttt 78780 agtatttcaa tacgggccac aaaacgaaga ccaatacggg attattgtcc gtgttgatgg 78840 tgttatccaa gaatcaatga ttctaagcgt taaacgtggc gataaagatg tttatggttc 78900 taatatcttt atggatgatt atttctttct aaaggttcaa gtaaattcat ttacgcaagt 78960 tcaatgaatt ggcctaaagg tttttctgga tttattaaat taggtggagg cgtatcatca 79020 aataaaactg tttctgctgg tgatttaatg caagcatggg accattttgc tgatcgtgaa 79080 tcattacatg ttaatttgct gattgctgga tcttgtgctg gtgaatctga agaaatagct 79140 tcaactgttc agaaacatgt tatttctatt gcagatgaac gtcaagattg tttagcttta 79200 gtgtcgccac caagagagtt agtagttaac gttccattgg caaaagctgt ttctaatata 79260 acatcatgga gaaaaggtag aagttcttca ggcgaagccc tggacaacaa tatgaacgtt 79320 aatagcacat attttgagat tgacggtaat tataaatatc aatatgacaa gtataatgat 79380 gttaatagat gggtcccatt agcagcagat atcgctggtc tgtgtgcaag aacagattct 79440 gtagcacaac catgggcttc accagccgga tataatcgtg gtcaaatcat gaattgtatc 79500 aaacttgcta ttgagccaag acaatctcat cgtgatgaat tataccaatt aggaatcaac 79560 cctgttgcag gttttgcagg tggtgatgga tttattttat ttggtgataa gactggagcg 79620 ttatctccaa caccttttga tcatattaac gttcgtcgat tgtttaatat gctcaagaaa 79680 aatattggag attctgctaa atacaagtta tttgaaataa acgatgactt tactcgtaaa 79740 tcgttcagaa tggaagtttc tcagtatctg gctggattaa aatcacttgg tgctatgtat 79800 gatttccgag ttgtttgtga tactacaaat aatacacctg cagtaatcga tagaggtgaa 79860 tttgtagctt ctatatacat taaaccggca agatcgataa attatatcac attaaacttc 79920 attgctacta atactggcgc tgattttgat gaattaattg gacctcaaca ataataaagg 79980 ccgaaaggcc tttaataaaa ggattaaaca atgaatctta cagatttaac acgtgccttt 80040 gaatcaggag atttcgcccg tccaaacttg ttcgaggtcg aaattccatt cttaggaaat 80100 aattttaaac ttaaatgtaa agcagctaca atgccaccaa gtattgtaga aaaaattcct 80160 gttggatata tgaaccgtaa attaaacatt gcaggtgatc gtacttacga tgactggact 80220 attacggttt ataacgatga tgcacattca acaagacaaa aattgttaga ttggtcacat 80280 atgacccata tggacgtggt gatgagattt caggctcttc acctgcagaa tataagaaaa 80340 ccgctttagt tcgtcagttc catcgtaacg gtaaagatgt tacacatgaa gaaactgttc 80400 aaggaatttg gcctactaac gttggtgaag tccaattaga ttgggattca aataacgaag 80460 ttgaaacatt tgaagtaaca ttctctgttg actggaccga ataataacgg gcctacgggc 80520 ccttattaat ggatataaat attagtaaca atggagatat tatgtttgaa actttaaaaa 80580 tgtttagccc ttgggctaaa gaagaccaat caacgtataa ccaaataatt aataataaca 80640 acgattctat aacaggtcct aaatttgatg acggtgctat agaatatgaa tctgattcat 80700 cttcatataa tgttttaatg cagcaattct tcggttctaa tataagtcca gaagttaaaa 80760 atacaacaga cctaattaaa acatatagag ctttagttaa cattcatgaa gtagataatg 80820 ctgtttcgga aatagttaat gacgctatag tttttgatga cgacgaagaa gttgtatcaa 80880 taaatttaga tagtacttca tttagcgatt ctattaaaac aaaaattcaa gaagagtttg 80940 attcagtttt aaatatttta gattttagaa gaagagccca agaccatttt agaagatggt 81000 atattgattc tagaatttat ttccataaag tcattgatgt taataatccc aaaaaaggga 81060 taatggaact tagaagatta aatcctttta atgtacagta tgttagagaa atcataaccg 81120 aaactgaaaa taacgtcaag attgttaaag gatataaaga atctttcata tatgatactg 81180 gaaacgaaag ctatactatt ggtggaagaa tatacggccc taatactaaa atctctatac 81240 ctaaatcagc tattgtctat gcacattcag gattagttga tgaatgcggt aaaaatatta 81300 ttgggtattt gcatcgggcg gtaaaacctg caaatcagtt aaaattacta gaagatgcca 81360 tggttattta ccgtattact cgttcacccg aaagacgtgt attttatatt gatactggta 81420 atatgccaaa taaaaaggca actcaacata tgaacaatat tatgaatggt ttaaaaaacc 81480 gagtagtata tgatgctacg accggtaaaa ttaaaaacca gcaacataat atggctatga 81540 cagaagatta ctggttacaa agaagagatg gaaaagcagt aacagatgta acttcattgc 81600 ctggcgcaac aggaatgaat gaaatcgaag acgttagatg gtttaatcaa aaattatatg 81660 aagccctaag aattccgtta tcaagaatcc caaatccaca aggtggtgtt aatttcggga 81720 tgggttcaga aattacacgg gacgaattaa acttttttaa atttatcaaa attcttagac 81780 accaatttga agcaattctt tctgacccac ttaaatcaaa tttaatcctt aaaaagatta 81840 taactgaaga cgaatggaat gaagaacgta ataatattaa aatcgtattt aataatgatt 81900 catactttac agaacttaaa gatgctgaaa tattagaacg tagattaaat atgcttcaaa 81960 tggtagaacc atttattggt aaatattaca tctaatcgtt ctgttatgaa agatattctc 82020 aaaatgacag acgaacaaat agaacaagaa tttaaacaaa tagaattgga atcaaaagat 82080 tctaaattta ataatgaacc cgaggaattt taaatggaag acatgatttt agcaattaaa 82140 aacaaagacc ttgtagaagt taaaaaactt ttttctgaag gaatgaaaga aaaaatcggt 82200 aaattgattg aatcagaaaa aataaaacta tgtcaaaaca ttgtcattga aggcgaagaa 82260 aaagaaagcg atgaagatga caaagatgaa gaatcagata ataaagataa aaaaactgat 82320 aaagcagaag aataaaggag atatcttatg attattgtcg aaaatgattt tgatatcacc 82380 atggaaaata ttgaacaatt ttctgaagaa gcgtctatta aatttgacaa tataaaagcg 82440 ctagaaaaag atgatataaa tagaattata gagaacattg cttctagtgg tgaatacggc 82500 ttagccattt gtatgggttc attaaacgaa aatatgccat taaatgaata tattgttaaa 82560 cacgtatctt ctaaaggtga agttacaaga accaaagata gaaaaacccc gtgaacgaaa 82620 cgcttttaaa acaactggtt taagtaaatc taaacgcaga caaattgcaa gacgcgcagt 82680 taaaacaaaa cgtgcaaatc cttctattca aactagagca ttaagaaaac gtaaaaaagc 82740 tcttaaacga agagaggccc ttggattatg agtgaaatgc ttttaatcga agactgggga 82800 ttaccaggtg aaaccttaaa cggaacaccc ttaattgaat cttcagaatc agacggcacc 82860 ctttatatag aaggtatttt tatgcaggct gaagtcgtta atagaaataa acgtctttat 82920 cctaaaaaaa tcttagaaca agccgtagat aaatatataa aagaacaagt taattctaaa 82980 caagctttag gcgaattaaa ccacccacca cgggcttctg tggatccaat gcaagctgca 83040 attttaatag aaaaactttg gtgggaaggt aataatgtct atgggagagc tagagtcatt 83100 gaaggcgatt atggcccagg agataaatta gcagctaata tacgagctgg ttggattcct 83160 ggcgttagtt ctcgtggatt aggatcttta aaatcttctg gaaaaggtta taacattgtt 83220 caagaagggt atagattaac tgtgggtgtg gatgttgtat ggggcccttc agcacctgat 83280 gcaatggtta ctcctaaaag gattcaggaa tcaacagata ttcctaaaaa tatagaaaat 83340 agtgctgata aggcattttc tttattatca aaacgtttaa aagaaacgtt ataaataatt 83400 atgtaattta acaacaggac ttaaaaatgc ttaaagaatt tttaattgaa gaagcagaga 83460 aacttaatga cgtttctgta gctctagatg gcattttcga atcagttgaa ttgtctgatg 83520 atgtaaaagc ccaattcagt actgttttcg aaactgcggt aaaatctaat gctattaaat 83580 tagcagaaag ccatatcact gaattaattg aaaaggctga aacaaaagaa caagagctta 83640 aagaatctat ccaagaatct gtagaaaaag aaatggcaga aaacatttct aaatttatgg 83700 atcatgtttc acaagaatgg ttagaagaaa ataaattagc tgtaacaaat ggtattaaag 83760 ctgatttgtt tgaatctatg ttccagagta ttaaaaccgt agttattgac cataatatta 83820 ttcttcctga agaatctgta gatgttgtca aagaaatgga agaagaactt gaagaaagta 83880 aatctgaagt agcttcactt ttcgataaga ctgtatcttt acaagaaaaa gtaaactctc 83940 ttgagaaaga aaaaattatc aaagaacaaa ctgccgagct gactgaatcc caaaaagaaa 84000 aagttgctaa tttgattgaa ggcattgctt atggtgaaaa attcaaatct agtttagaag 84060 ctattgtttc tatggtttct aaatctacag aagaaaaagc acctatttct gaagatataa 84120 ataatgatga gagtggtatg aactataccc cagaaaaacc agtcgttaaa aacgacccaa 84180 tgagtgttta tacagctgcg gctaaaaaaa tcaattaatt taatttaaag gtattaaaat 84240 ggaaatcaaa aataaagatg cattaatcga aaaatggggt gattttatga acaaccctga 84300 ccttggagtt attgaaggta ctactaaaca ggctattatg gccaaaatcc ttgaaaacca 84360 agaaatggac attcataaat ctccagaata tcgtgatgaa aaaattgcag aagctttcgg 84420 cgatttttta accgaagccg aagttggtgg tgaccatggt tatgacgcta gcaatattgc 84480 tatgggtaaa acaagtggtg ccgtaacaca aattggacct gctgtaatgg gtatggtacg 84540 tcgttcattc ccctaacatg attggttttg atatcgctgg tgttcagcca atgaatggac 84600 caactggtca gtacttctca ttacgttcta tttacggtga agatccatta gcaaaagatg 84660 ctaaagaagc attccatcct atgtttgctc ctgatgcaat gtacggtggt cgtggttcac 84720 acgagaaatt tgaaaaaatc gaagcttcta aagaattaac agaaggtaaa gtatatactt 84780 tcgaattcgc agaaactggt acggctcatt tacaagcagt tgaaactgta actatcgcag 84840 atacagaagt tgaagccgat gtacttaaga atttagaagc tggtaaatta gtagaaattg 84900 ctgaagcaat ggctacaagt attgcagaat tacaagaaag ttttaataag tccaaagata 84960 acccatggga cgaaatgact ttccgtattg acaaacaggt tgttgaagcc aaatcaaaac 85020 aacttaaagc aagctattct attgaactag cacaagattt acgtgcagta catggtatgg 85080 atgctgatgc tgaattaagt tctatccttg ctacagaaat tctgttagaa atgaaccgtg 85140 aattagttaa ctggattaac tatactgctc aacctggtaa aactggtatg actttaacca 85200 tgggttcaaa agcaggtgta tttgacttcc aagacccaat cgatacacgt ggcgcacgtt 85260 gggcgggtga aagctttaag gctctgttat atcaaattga taaagaagct gcagaaattg 85320 cacgtcaaac tggacgtggt gctggaaact tcttaatcgc ttcacgtaac gttgttaata 85380 tcttagcctc agtggatgtt aacgttactc cagctgctca aggtttagca cgtggtctga 85440 atacagatac aactaaagca gtatttgccg gtgttcttgg tggtaaatat aaagtttata 85500 ttgaccaata tgcacgtcaa gactacttta cagtaggtta taaaggtgct aacgaaatgg 85560 atgctggtat ttactactgc ccatacgttg cattaacacc attacgtggt agtgatccta 85620 agaacttcca accagtaatg ggcttcaaaa cacgttatgg tattggtatt aacccatttg 85680 ctgattctcg ttcacagtct ccaaaagaca gaatcacttc tggtatgcca tcactggatt 85740 caattggtaa aaatgcttac ttccgacgtg tatgggttaa aggttgttaa tctttaattt 85800 taaataggga cttcggtccc tatttttgct taaaaatccg tggttggatt ataaatatta 85860 gtataaccag aaggaaattt aatatgactg ataagattca aaatttattg cgcgaatcaa 85920 gtacaactgc gggttcttca aatggacgtc cggatcttgt tggattaact cgcgcaacac 85980 atgatttaat attcactgat ttaattgcta ttcaaaatac aaatcagcca gaagcgacac 86040 tttacggtgt taaatattta aatgacaata accaaatgag ttttatgaca cccgctacat 86100 attcaggtgc tgtaaaatct agagaaaata ttgaagaact tgatgtatca aaatcttatt 86160 ctaaaggtga tatggttaaa ttagatgagg tggtttataa agtagtacta gataacccat 86220 ttaaagattt aggttcttta acaaaagaag aggctttagg ccaggccatt attgatggtt 86280 caattagatt tatgtcagaa gcggctttaa cagggcattt tgaacaaaaa aatgtagaaa 86340 ttgctgaagc ttctgttata ttagatagat ggaatattcc tgtaagaact agaaaaatta 86400 aaacagaatt aaccgttgaa tttgcacaag atttaaattc aagtcaattt gaatcaggtg 86460 ctgtaattga tgacatgcta gctactattt tagctgaaga cgtaaacaaa gatgttattc 86520 aaaaaataat gactgtttct agtcgatata aagttaaagg aatttctgat aaaggaatgt 86580 tagatttaac taaaacggat gtggccccag aacaaggacg tactttatat cgatacattt 86640 gtgaaatgaa tgcttcgata gaaagaaaca ctacctatga tggaacatat gttttggcta 86700 gttcacgttg tgcagctatt ttatctgctt ctggttggat ggatattaat ccagattatc 86760 cattagcggc aggaacactt aaaaatggat taccggttta ttctgaccca tggtctcctg 86820 tagattatgt tgttgtcgga actaaacaaa atttaggtga attagaacat gttggttcat 86880 tgttctacgc tccttatgtt gattttgatg gggctggtgc gtataaattg gttgttgacc 86940 cagacagttt acaacctaaa ttggcattaa tggtacgtta tgggctttct attaacccgt 87000 acacagttat tgaagtagac gataaaccac aaaaagaatc tatgctaatt caaggagatg 87060 actgggataa tttagttggt aagtctaaaa tgtcttatat cttaggtgtt caattaccta 87120 aacttataga ataaatttat ttaatttccg gtaatttatt accttttttg ggaacttagg 87180 ttcccttttt tattaaaaaa gccaatctaa actaggatct gtatatccta tcatttcttt 87240 aaattcttcc attatcataa aattatttaa attataggtt ttaatcccta atgatctagc 87300 taaataaaca gctgttcttg taccaccaga aacatttcca aatttatctt caggggccca 87360 aaaaataacg ctatctacag ggtcttctaa tgtagggctt aatatttgca tgcaatttcg 87420 acattgcaga tgtttaactg ttttagaaca tgaatctaat tttggataga accttcttat 87480 tatattagca cttttgtctt gtaattcttt attaaaatca gtaaatacat gaacatcttt 87540 acttctatag tggttattga acccttggtt aggtataata atacatctta aatcatgact 87600 atattccttc ataaaattgt aatcactccc aggcgcacct cctgacaatc ctaggacacc 87660 ttgatctgat atgtattttc caccctttat taaaatatta tataatttag taggaatttc 87720 tcttgaccct attaaagcaa cagaattttt aatcataata taccctaaag gacccgaagg 87780 tccttcattt aagatttaac aatcaaagcc gcaatagttg taataacaat tataataagt 87840 aaaatacttg ctgggatcca taatggcgat aatacccacc accaagacca tgtaattgtt 87900 ccaacaagtt taagaacaac aaaaataaga gttaaaattt gtaaaaaccc gatatttaat 87960 ttcatattac caacctgata tattaatgac attagagtcg tattgggtac gtttaacttt 88020 aagaccttct tcttttagta cattaattac tgcttcttgg actatataag aagattcgtc 88080 aaaggcccaa tttaaatcag tgtgtcctga tttagcccta aaaagaagtg agtttttaat 88140 ttcattaagt ataacttttg aagctaaatc tacttgttca ttttttactt taataagtgt 88200 atcaattaac atataatatt cacccaatct tttctaataa attcttgaac ttctttttgg 88260 atagcttttt taattaaaga tgggtcatca tattctaaaa tatcattacc atctttaagc 88320 atatctttaa gaatatcttg catcattagg ccttgaactt taccaaagtc tttagtttta 88380 acttcaccaa tatgacttaa tacattagat agtctttgtt ttgtgatata tgctgtagcc 88440 gtattgacaa gttcctggtc atcatttgac aattcaacaa ctggttttac tttacgaact 88500 tttccggttt ctttaaataa ttcgtttttg cacttaaata taacacgact tttattatta 88560 aattctacag gaagtacggg ttttaataca taaccttctg cgatattatc tttgcctttt 88620 ggttgtggac caaaaatggt tgaattggct tcaggaatac catgttcttt agcaatgcgg 88680 ttaaattcag gaattaaact atcaaacgct cgttctaaat tggacaaatt atcaaaatta 88740 cctacagtaa taactggaca aattttaaac ccatgtttag aagaaaggaa tcttataaaa 88800 gctgcatcaa ctaaatttcc attaattaga atatcgaata cccaaaaatc tttttcttta 88860 taatcaactt cacgttgaat accagggcca gcgtattcac caaaaattgt taattcttct 88920 aaatcgggca tagattcttt aagaaaagaa tacatttcta aaatatttgt tttataccgt 88980 ttaagaatta attcatatcc aaaaaatgat tcagtttcgc ctataacact agttcgttta 89040 gcacatacta catctttacc atcacaaata aaactaaaat tagtaccatg gactttttct 89100 tgagcaatcc aaaaaatacc aggagaagta aatccttcaa aaaatgcttt ttcaactaat 89160 tttttgttat caatattctc aatagaacca tatttaataa atttcatatt ataccttaaa 89220 tagtctaatc tgtagttctg aaggaatttc tgatgtgtat ttgatttcta aattaaatac 89280 ccgtccactg taaataacta atatttggtc tggatttttc tctgcccaat caatattatc 89340 aggtccaata atattaagca tctctaaatc agagaagcaa cttaatgcaa aagctttttt 89400 taggaatgta tatatatcgg cccatttagt ttcatcacaa atggctggtt tagccactga 89460 taatttatgg gtataacatt ctttatcaca ccaacgtgta aaaaatgctt tttgtttttc 89520 ttctaaagga ataatacctg ccgtatacca actcataaga accccttatt tagatggaac 89580 aatgcggaat ttgtattcac caccacgagt aaatttaact tctaactgag ttgattcacc 89640 aacataaaga accaaaattg aatctttatt agaacgtaac cagtcttggt actcttcaaa 89700 agacttacgt aaagctggga ttttttgttt gtatcggcct aaaataaccc atgcgaattc 89760 accagaaccc atccatttag ttttacggct atattttaaa aggttttcaa tatcaatatt 89820 cagccatgtt ttaaaatttt ctctaatcat tttcttacct tcattcgttt acgataaacg 89880 attttttctt tagatttaaa ttccttctgt ttttcttcaa cttcaatgaa aacagaagcc 89940 atttctttag cagttccacc catttttcta gctatatcaa caaagtgcat accttgttgt 90000 ctaagaaagt ggatttttat tttatcggaa ttagtcatta ttttcttcaa aatctttaca 90060 gatatccaag agttttttgt ttaaagcttc aacaaattct gtagctgatt ctgggtattc 90120 gttaaataaa taacacaaat actcactatg tatttcatgg gccacttgag aaaccatagt 90180 attaagttct ttattcatat aatcacctct caataatgtg tattctatca tctaaaatat 90240 caataagcac agattcaacg ttatcccaat ttaaaccacc attagaacac ccaggtttag 90300 gtaggagaac tcttttaaaa ttgttattag atactatatc cataagttct aaagcactct 90360 ggcgtatcag agataaatca gatttatcat accagttata cttagtagga aatgaaatta 90420 aacttatgtt attatgtttt gtaagaattc ggcatacgtg gccatattgt attaatgact 90480 tagccatgat aaggtctaga ttattaacct tatcagaaaa gagccgggct ataccagctc 90540 ccattacagc tcttttattt ttcttaatat tcatattagt agttatacat attgcatcac 90600 aaggaatatt aagaatatcg ccttttatca ttttcataaa gcatatttaa gatgttcaat 90660 agcatttaaa atttcagatg gtattccacc acgtggatga tgatgaatat tgtcaccata 90720 atgtctaaaa tccataccaa ttacacgaac tttatacttg gtttcatgca aatactcatc 90780 tttataacta gaaccccatg tattagagct tgtaacttct tttgtttcaa aataagtaca 90840 tccacgatga caatagttat cccaaaaatc aacatcttta ttaaataatg gatgatcttc 90900 gcgaattgtt aaataaacag catagtccca atctggattt tcttgaaata actttttgta 90960 ttctacaggc aatccaacat accaagatgc tacttcaatt gcttcgcctt tttgagtatc 91020 attatgtacg gtaaaaacat attttaatgg gttcattata agtccttatt agttaagata 91080 atcaattcac aatcttcagt taaatcacaa aaatttaagg ctaaagaagc aatgcctgga 91140 tattcacaac tatctaccag ttcttcagta ttgttattag caatatctaa agcggtttga 91200 taacacgaag tcgtgaaccc aatttctaga tcttcacacc acacgatgta cttcatgagt 91260 aactccaaga aattttaaca cgatcatggt aagcaatttt atcatgggtt gtggaaacca 91320 taaacccatt agattttaaa actttgatga tcccttcttt aatattttca tcttcaggga 91380 gcttataata aagttcatta tatccgtcca tagctagatt actaatatct ctaaagataa 91440 atgacatggc tctattaatg acactagctt taagttcttc aacagtcata atgcttcctc 91500 acatgtttga ttgatgttgt aaagtatatc atgatatttt tttattgtaa acacaaatta 91560 tttttatttt tcttcaaaaa acagtttaca tatgctttca acatgatatt atagacatat 91620 caaaacacac aaacataaat ggagtatata atgactaaat cacaaattaa ccaaatttta 91680 aaaactttag gttacggtaa tttaaaatat gctaacggca aatcagtcaa aaatggtaca 91740 tcatttgtta aaggtataga acttcattca acaggtccaa tgaatatctc tgaaccacaa 91800 tatgctaaaa tggataactt aataaaagat ttatcatctc attttaacaa agaatattat 91860 cacaacagcc aaatagcagt ttttactact catgattcta aattaaaaat tattgtctca 91920 atgagagaat ttaacaccta tggatatgat agatatgctg attctggata tttaacacac 91980 tatgcttcaa tagttataga gaaaaactaa acaaaaatgg gaccgtaagg tcccattttt 92040 tatattaatc gggttatagc ccctatacct ccaccggccc cacctaatct tgttaaattt 92100 cttaatgaag aacttaaaga attttcttca gatatattat caatggctcc aacggtttta 92160 gattctagcc aatctaatgc ggcttgtcgt cctaccgacc caacttgcat tgatctatat 92220 gcaaatgtaa catcaaatac tgctatagta ttattgtctt catatgataa ttcaggtgca 92280 ctgacagaaa ctgggacaca tcctgtgaac attgcaacag tgtgtggtaa cccgcttcta 92340 ttatgcagat taacttgtat atcagcttct acatcgatag gtagggccct taatcctgtt 92400 attgggtctt caacagcatt aacccaatct tgcatagcac gataattact tgcttctgag 92460 tccattctaa atgatattat taaagggtcg tattctctag ataatatttt tatattagga 92520 gaattatggt ttttatccat ttcataagat aatctatttt ccggtaattt agcagaataa 92580 accattaatc cggaagttgg gaaagccata ttaaaaaaat ctagtaaata tgtacctact 92640 tcaaattcac ctaataatga ttgaacaaca cggtttgtca tggcacctaa aagatattta 92700 gatacacctg atttcctcac taatttttgg gtcccagaaa ctataagact agaaacagca 92760 cttgtcacgt caccttgggt tattcctaaa aaatccgtat ctattggcaa gttattaaac 92820 aaaaatccgc caaaattatc taacagctca tttgtttttg aagatggggc tgttgcaaaa 92880 acaacactaa acatattagt tcgttgaaaa tccaaattca cagcttgact tttaaattct 92940 tctaatgtat acattataat aatccttctg caaataatgt tccacgattt aatgttaata 93000 tttctctaaa tgttatttcg agagtaaagg tgcttggtaa atttggggcc attgctagac 93060 cattaaaatg accattagga gatttatcaa atcttatact tgatatttgt gctggaccaa 93120 atatgtcagt tcttccatca taagaagagg ttttaccgaa atttcgtata acccatattg 93180 ttggattact tacaaccaag acattagata aaaaacttgt tatattttct aatattgttc 93240 cagaagtatc ggccccagtt ggagtattag gatttattaa tgtagtttta taccattcat 93300 caatagctgc tttaatttct ttagcaaatt tagatacacc cgtttcccca taagaaaaat 93360 aactaaatat ttcatatata taaagtattt gaattaggtc ttggggtgtt cttggggtta 93420 gatgccatgt aaaaacttta gttctattat ccgcaccggc gtacatagaa cgggcagtag 93480 tataaatttg ttcaccttta tcagccataa ttccttgtgt tatagaatcc aatgctccaa 93540 aaacggctgt agaagccaca ttacttaaag ccccggttac agaaccgcca cctttggtca 93600 ataatgaatc accaacatca ttaaatctat gagaaatatt atctacgtca gattggcttc 93660 taggcattaa tatatttgca acagattctt gcttaaatgt tgtagttccg cctttactag 93720 aaaaatctat attaatagca tcaacggtac tttgtttttt tctaaaatct cttaaagatc 93780 cagtatctct ggcattataa ttatatgcag taaataataa gccattttta tataagtcat 93840 ttaatctaaa atctaaatca ttatctgttc ctgaagctcg ttctgccgga aattgtgcaa 93900 ctaaagtttt tgtcgggcta gttgtgggat tagaagcccc ggccgatact ttagttccta 93960 tattttcaac agattcttct aaaattttta gtttcattaa ttaacctcta gtgctttata 94020 catgccagga gcagcatatc ctgttacagg agtttgttga ataacagttt tattatttgc 94080 aacattattt tggaccttag cagtgtttgt tgtagattgg atagtagatt ctgatgtttg 94140 aatattatta atattttcag cactagtata atcttgggat tctttagggt cttcaggctt 94200 aatattaggg atttgttcta acaataagtc agatttatct aaggcctcta ttccaagttt 94260 ataataatcc gaatcaactt ctacactttg attatctata attgagcttg ctaattctct 94320 aagttcccta gctattttag acaaattttc cgggttattt ctttgagctt cagccatagc 94380 tataagatta tttaatcttg cttctgtctt tacttgttct tctatattac tatcttcagg 94440 attgttttga ttagtttctt taattgcagt atcagcctgt tcttgggtta taattccacc 94500 ttcaacaaat ttggccgctt cttcttcaac tgtagttcca aacattctag ctttggcttt 94560 aacaactctt gtccatccag aatcttcttc ttgggatgta tttctaacat catttccacg 94620 aactttggcc attaatttta attcatcatc tgttggcata tacccagtat ttttattata 94680 agcctctatc gcggcaactt ctaattcatc ggcccaagta tcttgtccca tagctcgaag 94740 taaagacgat aataatttac ctaatgcaaa ttgtatacct tgtaataaat tttctaaaac 94800 atttacaagg cctttaacta ttgctaatgc taaattacca aaatcacctt ctttccagaa 94860 ttttttgaca tcttctaatg ttgcaaaaat cgatcttaat attggcgcta atggcccaag 94920 tttttcttca aaatcatcaa aagcttcatt aaacaattta ccccagtatt taaaatggat 94980 cattatcaaa tccattgcta atacaacagc taacattata gcggcccatt tagcagcaaa 95040 taaagcagca cttactgtat atttaaataa catatctgct attctatttg tcataccata 95100 cgcagattta aacccagttt tgacattttt attcaaagtc ccaagaattt tacttaaaga 95160 atctttttct ttattgtcct ttttgggttc tttctttttc ttttcttctt caggtttagg 95220 tattctatca atatcttctt tattaataat taaatcttta atagcagact ctagcttaga 95280 atcttcaacc gggaccggaa gtttagaaaa tgcttcttct gtttcagata cttcaggctc 95340 tataacttct tgtttttctg gtttaaattt ctcttttaat aaattactta atttagagat 95400 attagaagaa aatgtatctg ataatttaga tgttgaagac gataaatcct ttaaactgtt 95460 attagtttct tggctagaat ctattaataa ttcaacacca gcttggacat cttggacaga 95520 agaatttatt ttagtcgagg tactttctat tgtctctgct acaagttcaa taccactaga 95580 taaatctgtc aaagaatcag agacagaccc cattgaattg gcaacatttt cttgtccttt 95640 ggcctcttta gatattttgt ttttttcttc tataacttta gttcttctaa atgaatcagg 95700 tgttttcatt ttggaataat cctaatatat catcgccata cacaacttta tcatctaaat 95760 ttatagcgat actttttccg agttcatcgg cccatttata aacaaaagcc ggcatactac 95820 caaaatctac cttttctaaa gataatgttt ctaataattc tttagcagtt gaaaattttt 95880 ctcctggtaa tatgtctcta aatttatatt cttttccttg atacgtaaat ttaggtgttg 95940 gtaaaatgta aacatcatta atagaatata ttttattgtt atactcaaat gtgtcgttgc 96000 attttccatt aaattcagct aaatgaagta atactaaatg ggcttcttta aatgataaat 96060 tcttatcaac cgagtctaaa acaattttta atgtttcttc aggagattta gcttctttaa 96120 atttttcata atagttaagg cctaatttag gaataactaa ttcttttcca tttatattaa 96180 tcttcttcaa cggaagaatt atctttaatt tcatttttta ccttaatatg atctacaggt 96240 ttaagaactt tactattact aaacatgtat atgtgagtaa aactttggtt attagacatt 96300 tcatgtataa cagaatccac ataaaatgta cttaaaaatt ggtttttagg gtcataaaat 96360 tccaatttag tcccaggtgt tatatcaaaa tcaccataag ttgtgcattt agcataagaa 96420 tcatattggg ccatggtatt aagcttagtt gcttcttcat acccatttct gaataattgg 96480 tcagaataac caccattgcg agatactaat atagaattct ctccattacc atttactatt 96540 cttgtacaat ttttatcaat catactaaat gaatatattg tagaattctc gtatggattt 96600 ctgttatatg aatttgtttt tgttatccat tcaaaatcat aggctaatgg gtattctaat 96660 tgatcggcaa attgcccgac cattaatggt tctcctacta ccatttcttt aactttagaa 96720 ttaataattt gttggaaatc cgtgatgtgg atcccattaa aatcatccca aaccaaagca 96780 aacatatcag atgcaacaga aataccagta tctctaacat aatccatata ttccttaatt 96840 cctagcaccc atggtactag aggtacgtgt atattggtcc ctgttatcgt aggttttaat 96900 agaggggcat ccgtatataa aacattaatc atttcttcaa tagtttctgt agcgttctta 96960 aagaatactc tactaaattt aagattttta tttttatatg gtggtattaa ttgcattgtg 97020 ataatattat cacctttttg gtctacagaa acagatgaat atttaacagc ataaattcta 97080 gtttttgata tagatgtatt agcatttcct acagaaatct gaagtatttg gtcaccatca 97140 agtttggtat gcatattctt atggtcataa atctgaagca tgccttcatt tgtcccatat 97200 aaatcatctc tgatagttaa tgtagtaaat gttccaccta gttcaataaa tctattttct 97260 aaccaagcat catagttttg gtagagtttt atagatacat taggatatcc cactctttgc 97320 atgttttttg tcctttatat ctttttctat taatgccaat gttatggttc tattcatagg 97380 ggtcattttc tctatatcag ataaagaata tccctgttta accattatat ggtttatttt 97440 ataaaatgta attatctctt cttcagaaag tattatttta aataaatcta aaatatttct 97500 atatgtcatt tcatgagatt cacaacaact aaatttaatt ggaatataaa ttggatatat 97560 atcttttatg atagtttcaa aatcgtctaa tgatataaca gacatgacaa gatttttatt 97620 ttcttggtct aagtcttccc atagatattc actattagca tcttctattt tatatataca 97680 actatcaaat aattgtttta tatcagttgt catgttattt gtaaaatcaa aatatatttt 97740 tatccccgaa gtctcaagaa ctggtctatt aagttttttt aattctaaat ttagaaatgt 97800 ctttttttct ttaccacatt tagggcactt gaatcttata ggtaaaacag ttttacctat 97860 tgatgccgta aaccatataa taaacgcata tggtctatat atttttggca tatcaggaaa 97920 agattcttct aaaagctcat ctaaaatttg ttctgcttcc tctgggtttt tttctatttc 97980 acttctcaca aaaagtaatt gtaaataatc atcattagaa aattgtctta ttctatatgt 98040 tttttcaggc gtaacaattc ttattatgtt catagtgtct cctcttattt atttataaat 98100 acataaaaag gagacactat gtttgaaata acatgcaatg atttaatata taaagccaga 98160 tatttcaccc tggatgaata cgaggcaact cttctcaaaa taactgataa taatattaaa 98220 gaagctataa ctacgctctt aattgattgt gtggattcct acgatacaaa tttacctaaa 98280 cactatgcag aatgtatttt tcttaaacta tgggcccata gtttaggtgg agtgacaaaa 98340 gacttaaatg gtgtttttgt caattttaat tatatagaat ctccagcaga aaaaggcttt 98400 atctataaaa tagaaaattt aagcttaaaa atgaggtatc caaaattatt tgaagattct 98460 gataagctgg aaatggttat taattgtatt gattctgtaa tattagaaaa tgaaacggaa 98520 ataaagatac aagacctttc atcagaagat atagaagctt tatattcgct tttaacaaaa 98580 gattctatta ttgcattaag agatgaattg cttagaccaa aaccatatat tgcttttcca 98640 cttgatggag aaatacataa aatagaaggg tttaaaaact tattagaggt gatagatgag 98700 taaaatgaat gttttatact ctgacttgga ccctaaaatg gaaaaaaggc tgggataaag 98760 atctacataa agttgtagga gatagggctg ttaaaaattc tattcttggg ataattagta 98820 caagaaaagg gtctagacca tttgatccag aatttgggtg taacataaca gatcagttat 98880 ttgaaaatat gagcccatta atagaagata ctatagaacg atctattgtg tctgctataa 98940 aaaattatga accaagggtt caacgtttaa aagtctctgt tactacatta tatgattcta 99000 attctatcat agtggatata attttttcta tagtagataa tccagataca ttagaacaaa 99060 taaaagttca attatctaaa taatttacta tagttattaa tttattactt aatagttata 99120 tagaatatac tatactttta ataaaataat aaactaagga aactattttc tggagcgcag 99180 ctccagattt taataacaca gagttattaa tttattactt aatagttata tagaatatac 99240 tatactttta ataaattagt ttactatggt tattaataat aggctattat tataatttgt 99300 atataatgta tctttatgga ggaattatga atttagaaga attacaaaca atgttatcag 99360 aagacctaaa aatagattcg ttaaaacttc aatatgaagc tgccaataac ccatcattat 99420 atgctaaatg gttaaaaatt tattctgata taaagaaagg aattatttct tatgaggcta 99480 ataagaaaag attactaaaa caacgattag accattatac aggccgtggc gatgaagtat 99540 gtatggattt atatgaaaaa tctgaactaa aaactgttat tgcggctgac ccagaaatat 99600 taaaaaccca aacatctgtt gaatatagaa atcttttatt agattttgca tccaaagctt 99660 tagatgcaat aaaggctcgt gggtttagca ttaaacatat tcttgaatgt agacaattcg 99720 aggcaggtac aaaatgacga gcattgatat cattaaagaa aatttagata tggtattagc 99780 aatggagaat ttgacaacag attctcaaag agacttagct attaatgcaa tgaagaagca 99840 tttaactaat ataaataata ttaagctgat ggctgaaggt attgataaaa gtgggttatt 99900 acctaattat tctttaccac aaataattga agaaataaaa ggatgggcta tgaaccatat 99960 ttgtgtagtt tgtaaaaagc ctattgatga gagtttagtt atctataacg ataataatga 100020 acctgttcat cctgggcctt gttataattt tgctaaagaa caacctgtaa cagaatcagg 100080 tcattcttta aatgaagtag aattattatt gtaaaaataa aagacgaggg ttactcgtct 100140 ttttctgttt ctagatcttc taattctaat cttttacctt ctaatgcatc tctgatagaa 100200 atatcatctg tatctttaat ttttaattct ttaattcgtt tagaataata tttttctaac 100260 tcttctaatc cagccaatgt ttgacattct ctaattttat tcataaaagt ttctacacta 100320 gcttctatta aaatatcttt aaacgatatc ataatttaac ctcttttagc atttttctaa 100380 ttatatgtct agataaacca gtaccttctg aagcttgttt tatagacccg tattctttgc 100440 catttatgat acatattttt gcggcaggat ttttactagg atctttgtat cgttcttttg 100500 ctgcattaga tatttttatt ctagcttctt tagaatgggt tttaccaaac ataccgttgc 100560 cttggccaga attcctttta gaaatttcaa gcttctcttc atttgttaac tttctaggaa 100620 acttgcgttt tgtttctaat attttgtcaa cccaagtaat ttttctacct gtatataaaa 100680 ggcgcaactt ggatttaaat tcttcagtgt gggtctttcc gtaaaatgga ttaccagttc 100740 ctgattggag ttctgacatt ttacgtcttg cataagcata tgatttatta taatgtcttt 100800 tatgagtgtg ggattgcatt cccatagata ttaaagccat tataatttta taattgtctg 100860 ggtaaatttt agttaacaac ttatgggcta gaaaatgctc ttctgcttta agcaaaacca 100920 aattatcaca tctatcacta ccgcctaaac accttggtac tatatgatgc ttttctgtat 100980 aataatctaa ctttgatttg ttgaggcctc ttttaaggcc tctagatatt aaatcgtcat 101040 atattttttg ataattcaca atttaacctc ttttatgata taatcaaatt gttcctctgc 101100 atagcgttgg atcctttcta gaccatggcg caaagcgtaa tttatatggg tatatttctt 101160 tttagcattt tctgatttag gttttacacc catgtcgtca attatgtcga ataattttgc 101220 tactgttttt gaatcatgct ttctaagaac acgacctata ctttggagaa ctgttacttt 101280 ggatttaata ggatgtgcaa atataacatg gtgtaaattc ttaatagaga caccagcact 101340 aaaaacacca taagaagcta ctacgaccat ccctgagcgt ttttctgcca tagcctttat 101400 aatatctcta tctttatctt taacctctcc tgcgataaag aagacattct cttcaccatg 101460 gatagattta caatattcgt aaagatcttt accgtgtgcg attctatcaa acatcacaaa 101520 aacattttca tctttggacc caagtttaca agctaactta gcaatccatt cattacgttg 101580 ttttgctttg ataattattt ttatttcatc ttgatatgca aaacctttaa ctttttctgt 101640 aaaagcatca ggatatctta aaaataaagt attgatttta agcttagaga cttgtcctgc 101700 ttccattaat tctgctgtag atactggacg atagatgttt ccaaataatc caatatattg 101760 cataacatta gctttaccgt cttttactgt accggttagt ccaaatttaa atttacaatt 101820 acttaagcca ttgataatag tactaatgct cttcccggta gctagatggc aattatgtgc 101880 caatgcacca tttgcaaaat aattgtgatt tgttttaaca tgtaaattat aaactgtttc 101940 aggttttttt atttctttta tactttttaa tcgcattttt cattttccta gcagaatctt 102000 ttaatccatc ataatctata agatgttcat tttctgcaaa atagtcaata tctatatgaa 102060 tgtatttata cccgttagtt ttacaatatt ttttagcttc taatatttta ggatgattct 102120 catcatacag tgatttcggt cttatttcta taacttcttt tgattttgga tcaaagaaat 102180 ccgctatata aatatgggtt ttgttatctt cacctatata tggtattctt attttttcat 102240 atagataatt aggattgata gatgcaaatg aggcttccca gctacttctg taatttttac 102300 cattataaac aacatcaaaa caagtatttc tattattcgt atttggagta aattcgccat 102360 tcagtatttt tcttttcata gtctggcttt gtttttctct ttgctcttta ttatcccaac 102420 catacattcc attattaaca cctgaattag ctttagatat tttggtttta attaattccc 102480 atttatcagg atttgttata gagagatggt gttcatttcc aattttctta cctttattcc 102540 atggagtcct gcctttatta atatctttag gaaaaccacc taagtatttc atttggcatg 102600 atggattaca atatagatta tttgggttgt ttaaaccttt attacattgt aaacacctag 102660 gctgtgaaat attatgttca aaacactgaa ctaataaatg cattttagga ctacaccatg 102720 gaaacatatt aataagtttt tccatagttc catttttcat catctttctt gttaaaatgc 102780 ggccactagg gccgcgaagt atatttattt ccattctaca atatcatcca attctgttaa 102840 ttcatcagcc cgtacccatc cacaattttc tgttaaaaat ttatgattac ctgtaacttt 102900 aataatagta ttattatcca tttctaattc atacattttt tccgaagaag acttagttaa 102960 atttttatgt aattttacaa cttcatcttc tactatttct ttagtttttt cgttatatga 103020 atatattggg tcaccaggtt ttaaatcttt tattttaatg tcgcctttag gggtttttat 103080 taatgtatca ccatcaaagc actcatcatt cattagcatt ccgaactgtt caaaccattc 103140 tttaggttgt tttatggccg tttgccatgt tgacacataa accaatgcat cagaatcttt 103200 agctgtacca cctttaattc ctagaagcat ttctctagaa aatagtctat agtcaactaa 103260 atcatcaatc atttgtttaa caaggatagt agtaggaact aaaattaaaa ccttaccttg 103320 gaaattctca atataatatc tagccaggag tgcctggatc aacgatttac cagctgatgt 103380 aggtaaattc aacaatgccc tgttttgtgt caggccttta actacagagt ctttttgata 103440 ccaatgaggc gttatcttag tagaaccaga ataaacttct ttagagtcca cccaatcaga 103500 aatttctttt tctgtaattc cgccgttgtc tgttatttta gggtctattt ctactttata 103560 atccatgtta tcagcgaatt ttttaacata gtccactaat ccatatggaa gtaacccatc 103620 atatcctaaa atacgaattt taccgtccca ctgcccatat ttgaatttag gattaaactg 103680 gtaacctggg gtttcaaaag aaaaataatc tctaagttca aagaaaatag aatcttcaca 103740 ttcgattttt acactactat aatcgtaaaa ctttaattta atatccatta ctttcacctt 103800 attataaata catatatatt tatacaaagc ctaaagagga cattatgaaa attgaccaac 103860 aatatattga ttctttaact gaagaatata cttcaggcga aattgataga aaaacagcta 103920 aacaaaaatt atctgaatat gcaaaagaat cgtttaattt tgatttaaac aaacaaaaaa 103980 gttttgaaaa catgattgtc caacttaaag aactgattga caattatgaa gaacccgaat 104040 tagaagatca agacggcatt tccattaaag atctaattac cgcagctgac caattagatg 104100 gtaaaagtgt ttttaatgat gctaatgaag aagctattga tcttatagaa tctatttcga 104160 caccagaaga tcataaacaa tctaaagaaa aaactattgg tctagaaaaa ccggtggttg 104220 aaccagcgaa tgttgaaaca acaaactctg aagtgcagga atcacctgta gaacatccta 104280 caacacaaga acagataact ataaaagaaa attatatcct tccagaagag ttctctccaa 104340 ctattacctt aataggcaaa gctcctggat attacactct cccatggtgg atttataaat 104400 ggattttaga aaatgaagat tggaaatctc gtcctgaaga ctgtcctgaa ttctctgcaa 104460 ttaatatttt aaaatcgtta atttatttta ttaaccgaga tggacaagtt aaaatacgag 104520 aaactagaaa ttctagattt tatacactaa aataaaatgg aaaaaatatg ccaacactaa 104580 atatatctcc tacaaatccg tctataacat taggacagac tcaaaagttt acagcagaaa 104640 tattagaccc aataccagaa tcagttacaa catataaatg gtttgttgat ggtgaacttg 104700 atgatacatc agctacagaa acatttagtt taacacctaa tactattggc gaaaaaacta 104760 taaaagtaga atcaacaagt acaggttcag aagaaccagt agttttgaca gatgaaacaa 104820 ctttgactat taaaaagaaa acaatgaatc ctattgttaa tattgaagtt gataaatcta 104880 ctacagaagt tggaaataca gttaaattta ctgttaaaat tgaagacgtc ccagaaggtt 104940 catcaacaaa atacctatgg gattctggag aaactgaaga atctattaat gttgttacta 105000 cagaagttgg agatcttaaa aaagagtgta ctgttactat atctcatagt gattatgaca 105060 ctaaagaaat taatgtatct tctactgtag atgttacagc taagacaatg gatgacatta 105120 tacttgatat tgttataaca ccagataaag taaaagttga cgaagactac gaagtagaag 105180 ctattgttac gggtggtccg tctgacaaat caatcaaata taaatggaat actgggcagg 105240 aatcatctaa atttacaata acggcaaaag atattggtat aatcaaatat gaatgcacta 105300 ttacagtaga tgccaaagac tatttatcat ttagcaccaa atcgtcccat tcggttagta 105360 tagaaaaagc cccagaagag ccagaaattg catgccgata cattcatcca ttagaccata 105420 gaaaatctgc atatttgtgg gttgggtatt gggtactaga agaaatagaa aaagccgtgg 105480 aagaaggaat tgattggaaa aaaccaaata atacagattt aaaatataaa tgtaacttac 105540 aaacacttgc tgttatgtta gagacatatc ctaatataga agttcaagaa tcaagaaatg 105600 gatatatttt atctaaagaa gatattgaaa atggagttat ttactaaaca aaaaagggac 105660 catatggtcc ctttttattt ttattttcta aagatcttac caaatttact aatcacaaaa 105720 ttctcaccaa ctttaatatc aattcttatt gaagtatttc caataatatt tgaagacagc 105780 atttcatcta aatctattga agaaattcta tcaaaatctt gaacaatatt aaacccacca 105840 ttatcacaga aggaatcaat aaattcttct attttacatg aacactcatc ggataatata 105900 tctccatata aacgacaagt agacccgtca atattcaaaa taaccataat attctcctat 105960 ttgtttagac atgtagataa taccacatgc ctattttatt gtaaacttaa aattcaccca 106020 tttcttcaat aaattcttca tgatcaaatg ggaacatctt ccaaaattct tcaacctttt 106080 catcagaagt aaattctaca aataatcctt cagagtctgg taaaatttga actatttcca 106140 tttgtaattc tgaaatagct ttgaaatgtt ctgaagttaa agctcttatc caaatatgaa 106200 aagttgtcat ttttatttct cctaatatgt tggtatagtg gtataatatc atattagaag 106260 caaaagtaaa catttaattg ataaattttt caggtatttg gtcaaaatcc attatatcgg 106320 ctaaaataga catggcttca gacgattcaa gtgtttgatt ttctttaata atctcttgtt 106380 ctttaacaaa atttctaaag ttaatttttt caagaacacc ttcatttaag aatttatcac 106440 catcgaaaac gtctgtacat tcaactaagt cttctggtgg catatacaca gtattgataa 106500 gaaaagattt actcaattct cctgacccgt gaatagatct aatttttaaa gctgaaccac 106560 gaggtaatat aacttcagat tcatgagaaa atctagaaag atcccctggg acaataactt 106620 tgactttatg aacacccgag atcataatac caagtctagc aatataatct gatttatact 106680 ctgctttaga atctactact ttatccccta aagtttccct agcttgtgtt tcccagtctt 106740 gtggttgtcc tatataagaa gaagcagaat tagaaaatcc tttattaaaa aatacaggtg 106800 ctaaagacgt cgaaacaaag tttgggaaat acaatatttt attttgaaca cttttatcaa 106860 gatctttgta ttcatggcgc tgggccctat atagaatcgt agatctatct aatttaactc 106920 ctttagaaaa ggctttgtct aaattaggga tatatgtatt aattgtcttt ttagtggctt 106980 catcatttcc taataaaaaa ctattaatat cttcataatt ctgacttgta tagtttgtta 107040 ttgcctcttt ttcttctgct gtatagtcta tggattcttc tagatttcta taagagctac 107100 ctactacatc ggtatatgaa ctagaaatag cttgtataat tttactgata ctagatagtt 107160 tttcagagta ctctatatca gaaggcaaat attttaaagt atactcagta atatctttaa 107220 atttgaaaat aatttcttta tcagatttta aaatttctga aagtttcaac atatatggtt 107280 ttatttttaa atctagttca gatggcgata aatatttatc ttcattatga atagctaaga 107340 caactgctgt tcgtatatta tctaattctg tgtggtattt tgactcaact tgttcatcat 107400 cagacatagg caacatatca gctatattag aaaatgtttc tttagttttt tcattaactc 107460 gtgtttgaat tctggaaaag ggtgcatcta cactactata tataggtgga ttaccttgga 107520 acttaacaaa agcttcttta gcttctttcg aatagccatc taaatcgtct ggtttagaaa 107580 tactatacaa tgcagtcata agctcacgtc tagaaacttt agttttagaa attaaagaac 107640 gttcatttct ttcattttct tgggctgcaa tactaccagc aatggcttcc attttagaaa 107700 cttgcttacc tgttttatca ttaatataaa catcaccgac tttagattct actttagtat 107760 acaacgatga atctatgtca ggaatcccag agatgtcttc taatggttta tttttacggt 107820 atataagaac atatgcgtgt ttaccagtaa attgatagag gtcttctagg actacaaatt 107880 taccacctgt gcgttgcata gccaatcgtt taataatacg ttgtaaagat ttttcttggc 107940 ctttcatttt cttagctggg aatctgaaca atacagcatc tatttttaat tttttaactt 108000 gttcataaac agtatcaaaa atagtattca aagccccaat agggtctgct cctaatccat 108060 ttcttaactc agaagcatta ccgtttttag ataaactcat taaaaatact tggacaaatt 108120 tatcgcccat tttaacttgt tttactgcat cccctttaga caaataagaa accatacgaa 108180 ccaaaagatt atcattacct gggactttta tgttccaaag ctgtggaact ttcgcttttt 108240 gattaacatt aatagcttgg tattgagcta tttctgaatc aaaaacttca tttaagttaa 108300 tttcatttaa ttccatttta tcacctttat aataagaata tactattatt tatagcaaaa 108360 aagggcctaa gcccttattt ttatgtattc cttttattca gatattcttg cttctaaatt 108420 taacgtatca atttcaacat caaattctaa aacttctgga ttttcatcag aagatatagc 108480 cattttgtat ttttctatcc cattttttga tgataataaa gtagatttga ctacattaag 108540 ttcttctaca tattcaaaat caccgtaaat attaccatca gtttttgaag cttttttgaa 108600 catttttaat aactcatcat ttgaatattt cattttaatc tccgtttgtt ttgatgagtc 108660 tatagtatca aacttaaaag caaaagtaaa caaaaaaagg gacaaaagtc cctaaataat 108720 tttttgaagc tctaaagaaa tattttttag tttttctacg tcggtttttg taagattaga 108780 tttcttatca agattaaaag aaaccaatgc gttattccaa atagtttctt ctaacaaatc 108840 taagttatcg tttaaaatat tcttctggtg attgtccgaa gatttcataa aaatcattag 108900 cctcttgttt atcaagacgt cgcattttta cacggggtaa aaataaacta taagtttctc 108960 gtccttctac cttttgggct gcattacata caccagaaat aatcatgccg ataagtttgc 109020 cctgtttatg taaatcccat aaaagccgac ggtctaattc atgacgttct tctaatggaa 109080 tccagacttt tttaccttta actttttcgt aatctttatc tttaaaccca gaaccacaat 109140 caactaaaat agttccgtct ctagatttta aattaacacc accaagtttt tctgggtctt 109200 tagaatgtgg ataagcccca ataatttcta ggtcaaaatc tttttcttct ttaaatttga 109260 cctggtcaca agtacgccca tcggcccaaa taccattttt attttttaaa ataatacctt 109320 ctaacttcat atctacatat ttcctgtaaa taatctgtgc ctcttctaaa gttttaactt 109380 cttctgaagg gattaattca aggcgttctg aatttaaggt aattttttct aagtctttta 109440 aacgggcttc ataaggttta ttgatttcat ttttatttga agacgttcct tgtgtaactt 109500 cataattgat taaatcccat acttggaatc gtacacaatc tgcttcgtct ttagtaattg 109560 ttccttggat agatttatta gcaattccgt tgccttcttc ccgagatgca acaatatttt 109620 cttcttcctc ttcatcaaaa aacatatcaa gaccctgttt tttagattta gggaaatata 109680 ctaattcacc atccacaacg acattaccaa gtccttcggt aatttttaat atttcttctt 109740 ttaatgaatc caatccttga tattcgctac ctgaacgaga atataaatta acttcaccat 109800 ctacaacttc agcaaaacat ctagccccat ctgcttttaa ttgggctata gccgggaatt 109860 taattttaga tacatttgct ttactaaatg gcgctgctaa aaattgcggc tgtttaggta 109920 aaagattttc ccatacttta ttaggaatac ttctgcctac accacattct aaatcacgtt 109980 taataatacg tttaactaaa gctgcatctt ttggacataa actttctagt acttctttta 110040 acccggcaat acctgcatgt cctgttaaaa ctctggctcc taatacattt tctaaaaaat 110100 ctaatgcatc ttgtaaagtt ttagattcat ctttaggttc atattccgga atctttttaa 110160 tatggaattt gaccttttga gaatacgtta atctaaatac atctttaaca agatgatttt 110220 gtttatattt taaaagaata gcttcttttt cttttaatga atctgtagaa gccaattcaa 110280 caataatatc gtataccata cctttttcca tttatagtcc ttattttata ctatttaatg 110340 attcttctaa gtcaggtaaa attgtttcaa agtcatacca atctttaaca ttgataatag 110400 gacaatctgg taaatcacgc ttaccacgag gcatatggat aagaggtaat ctagaaataa 110460 ctttatggca atcttctaga ttgtgagcca aatcatcaac aaaacataac agatttttag 110520 tatgttttac tttaacatct aaataatggg gcgttttgga ttcaccgtaa ttaactaata 110580 aaatatcgct aaatgcattt gggaataaag aattcaagtt atataaacga ttaaataatg 110640 cttggtctgt tgaacctaat gccgtaatag ctacaaattc atatttgtct ttaagacgat 110700 taattacttc aattgcatca gtgtagccgg ttaaaaattt aatgtatttc gagttattat 110760 attctgtcat taattttaag ccaagttctt cgttacaacg aaacatttgt cctggcgaca 110820 taaatacatt ttcagtaata actttaagga tatttgttgt atcgatacca taatcttgag 110880 caaaataagg aagtccagat gcccactgga ccaagatacc atcaacgtca gttaaaataa 110940 caggttttaa attcatttca catcctcata ataaacactg acagaagcat ttgcagtata 111000 ctcaaagatt ttaacaattc tttgattatt atcgcttaag aattttttaa tttttgtatc 111060 aagttctttt ttaatcaatg gacccacaat tgttttagct tctccttcga taaatacagc 111120 tattagctct ttattttcta cttcttcttt atatgatgat atattttcta tttcttcaaa 111180 aaattcatat tcatcacttg tcaaaataat agataaatcc ttttctatgt cttcaccatt 111240 ataaatttta ttattaaaga atatactagt tacagacccg tcaccttcta tagaatctat 111300 tttaaacggg tttgtaccaa taaattcggc aatagctgca ttatacatag attcccttga 111360 aaacatttca ggtttatcta acttgtacca tttatttagc tcaaacataa tatttcctta 111420 gttataaact acgcccatag aagccacttt agaaagaaca taaatttcta cttttccttt 111480 agggttgtta gataaaaaat cctcaacaca ctcatctact ttatgtttag cagttataag 111540 tgggaatgac ttaactccat ctaaaatttg gaccagtact acacaatcgt cttcatcttt 111600 atcatcagaa gtttttttaa cttcttcaaa aaaccaggct tcgttttttg aaaaaacgat 111660 atctaaccca gaagaaatgt cagatgcaat taattcgcgg ccattgacta aaattttact 111720 tacatttttt gtatcaggta aaaattctaa caccttaaac acatgtcctt caatgatatt 111780 atatattttc tcgttataca ttgattcatc aaaaaactca cttctagaac cgacaaattt 111840 ataccattta tttaactcaa acatattatt ttcctattgt cagtttaact ttataatctt 111900 aagttatttt aattaactac tctttttctc aaagccatta gtataccaca gaattcttta 111960 tttgttaata tagtttcaaa tatgttttca ctacctatac tatgaactag tttcttattg 112020 cctgtgtacg ccagggcatc cctgaaagat ttattctggt taaacatatg aatatatgcc 112080 ttaatcaata aacgtttgta ggcttcgctg tgtctattaa tgggtgttcc tttataccac 112140 attgtgttgt ttttaatttt tggacctgct agtttagctt ctaatccatg tagtttaaaa 112200 acacgtttct gttctatagg gtcttggatt tttagacctt gtaaaaaacc ttctatactg 112260 gcaaattcct gattatccat tataaaagga tggtatgtaa aattgcttaa ttcattagac 112320 attagagggc caagaccctc tagaatgaat atcaacaacc tgagaactca tatgctttaa 112380 cctcgttaca acaagatacg cgtttataaa tgacccaatc agttgggtca tattttccta 112440 aaactacttt ttttgcttca tctaaagaaa gtccatctaa atctaattcc atacgtgatg 112500 gattaaaaac agcataaatg tcttctgatt cttgttgatc ttgttttttc tgtggttttt 112560 ctaacagatt tctttcttca tctgaagaaa agaaaatatc aaaaccttta ggattttttt 112620 cctctgggat aatatcatct acagaatata atttcataac accttgacta gtgataatcc 112680 ctaagatatc attactatca tttaaccaaa aattaggaaa tcctaatttt tctaaaaact 112740 caattaaaca tatgttaaaa ctatacgtat attggttatt gcttaaaaca gatgtttttg 112800 tgatttcagg gtgttttaat ttatactcag tcatagtttt catagtatat cctttaaatt 112860 aaatcagttt taattatact acactaattt ttagtacttg taaacactta ttttcaataa 112920 aaacaaaaaa ggagaccgaa gtctccttaa atttatttta ttcatagcga cactaagtct 112980 aagatacgct tcatttgact aataattgct ttaccagaat cattatcata aacaaatttt 113040 gttaatgcta tatctcttat agtagttgtt tttgctaatt ctttaagatc gttgttaaag 113100 aaataaagtg catcagcttc attgtcgaaa tacttattat aaaccttttt ttctttaaca 113160 attctatata ctaaattata tacagttgat gttgacattt tatacctccg ttattaattg 113220 tgatctataa tatccttttt taaaagagaa gtaaacactt attttcaata aaaacaaaaa 113280 aaggagaccg aagtctcctt aaatttattt cttgttacca aggttagcta aaaacttagc 113340 tcggccattt tcttgtcgtt taacaaatcc aaccaattta tctaagtcct ggttaatacg 113400 tttatttgtt tttcgtttgt aacctttacg tgcagacata ataattcctt atttcaatgt 113460 aacaatataa tgacgaacag ctttacgggc attggaactt aaatgcttag catattttaa 113520 attatcattt tctaaaagct cttgatgaag agatttttga gccggattta aatgtttaaa 113580 accttcaaga acttttagtg cttcggccag aacatcaatt gatgctccat aattttcatg 113640 gccattttga aaagaattac gttggatatc taaaattgtt tttacaaaag tcataagtgc 113700 ctcaaaaatg cgaggttaat atttagtggt caaattgacc accgtttaga acattagttc 113760 atatacttat ttataaaccg ctgcgattga cctataatgg gccgtaataa atttttggtc 113820 taattctttg gcttttttat tattaaaaac cgtttctggg tgagggacat tacgcatatt 113880 accatttggt aaaggcacaa cgtcaccaat ttcaaaataa cctttaggaa cactatcgcc 113940 gatagaataa atttcaccca attgtgggat ttctccttcg gcccgttgag ttgaaataat 114000 aataccacta gaagatcgtt cttctgttcc tgcagattta gcaattgccg tgataacaac 114060 ggattcgcca agagctttaa tatctttcat taaaccaacc ttaaaatttc ttcatacaac 114120 atagaattaa cagaaataat attttcagta ataatagaac gccatgcatt aatttcggta 114180 tcaaatacac gaatataact tggagtttta gtttcttttt ctgttaacag ttttgaatca 114240 tcttgtttag gatgatattc tgtaggaata atatcataat ctaacgtaca gcgaataaca 114300 cgaactgaat tatctttttt cttaaaaacg atttcgtttt taccattatg taataacgta 114360 cgaattaacg catttaattt agtttttctt tcttctgtaa gtttcatttt acaccacaat 114420 agttagttat agtagaccaa tcaatatgat taagattaga acgttcgtat ttaataactt 114480 caatgcctga atctaataga attttgtccc aaccaggaac atttcggtca tatgtttctg 114540 catacacgag ttttttaata cctgattggg caattgcttt agcacagtca gggcaagggg 114600 ataatgtcac atacatagtc ccgccatcaa tagaaatacc atttcgagca gcaaaaataa 114660 tagcatttaa ttctgcatgg atttcatgtt tagaagacca atcattatga tgttcacgga 114720 attccatatt taacccggtt atagattttg gtctagaacc accattaata attaaaggct 114780 tagtccaacc ctggtcatgt gcatggtcac aacagttaat accacccgta ggagaaccgt 114840 tatatccagt ggaaatgatt cttccaccct tttcaattac cgcacctact ttccaagata 114900 cacatttaga ttcttgagaa ataatatatg ctaattgtaa atacgtggaa gctttcatta 114960 atattttcct gtatattcta ataattttga tggtgtttga acaacgactt caaacataca 115020 aatagttgga ttaaattcaa ctgaaaccat atatctggtt ttatattccg ggtccattaa 115080 cccaattaaa tcccaaatat tatcttttaa atcaattcta taccatggag aagcaacttc 115140 aaacatatta tttatatgcc actgctcaat atataatctt agcatttcat ctagattttc 115200 tggtgaagta tgatttaaat gttttttaac ttcaaatttc attaatgttt tcctactaag 115260 ttaaaataaa ctaaatatat tgtattacga gtttttacaa gagcagattt atcattaatc 115320 atttcaaaac ttttaatagt agaagttgtg acataagaac cattataaaa tcttttcttt 115380 ttgtcgtcac taatatatcc tgataatgaa aaactaccat ttacagattg atttaaaaat 115440 tctttaattt cgtctacagt ttcaaaagta tatacaacat ctaaaactgc atcatattga 115500 atatctttat taatcattat aattccataa ttaaatttgt tgtgtctaat ataccaatac 115560 atgggtctgt aatagatacg ccccataaaa gattttttga tatcttttga ttaccttctt 115620 ctaaattgct ttcaatcata aggccaaaag tatttttaga cttaattgct tctttagcaa 115680 cttcaatttg ctttttaaaa tcaccttcac aattagaatg tgaacaatcg accattacag 115740 gaatatctaa actgtcaata tattctttag aataatttgt tttgtattct ttaccaattt 115800 tgccaccacg taagataaca tgagtgtttt gattaccatt ggcataaatt ttactaatta 115860 caccattcat atcaatacct aaatatgaat gtggaaatgc tgcgctttta atagcatcta 115920 aagccacttg aatatcacct gaagtagaat ttttgaatcc tacagccata ggtaatcctg 115980 aagcaatttc acgatgggtc tgtgattctg tagtacgagc gccaatagcg acccaactaa 116040 aaatacctga tagatactta atagtaaatg ggtctaagac ctctgtcgcc aaaggaagcc 116100 caagattcaa tagttctaaa cagagatggc gggcaattct taacccttca tcaatattaa 116160 aagaaccatt taattctggg tcgttgacta agcctttcca acctacagtt gtgcgtggtt 116220 tttcaaaata aacccgcata accaatagat atttgtcaga cacatgtttt tgcaattctt 116280 taagatattt tccataagta atagcttgac cagggtcatg aatagaacat gggccaacaa 116340 caattaattt tttattaatt ttaccagaaa taatatcttt aattaaatta cgatgacttt 116400 ctacttgtct agataattca ggagaaatag gtaggtcata atgtaattct tgtggggtac 116460 taatagtttt aacgtgcatg gatatcatat tcctctgaat ggattagatg agtatcatct 116520 tcatccttta cccataattt taaactaaaa atcccttgtt tgcacttaac ttcccaaaga 116580 acatcagatt taaataaggt tttaaaaata cgagtaactt gatagataat agcttcatcc 116640 gtataagcat aatcagaaca catagaaata acaccttgtg ctaaatcaga taatgacaat 116700 tgcttaggaa ctttatacat cataacattt tctccaatca acatttccat caggataaag 116760 tccaataata taataatcat tgcctttatt agtttcaatt gtaactaaga cttctttaat 116820 aaacccagaa ttaattgttt gggttgaatt taaatacaca acagaatctt caattttttc 116880 tgaaagggcc tttgccaaag tatggacttt atctttaaac atattctttc ctataatgaa 116940 acaaatactt ttctaatttc gtggccaggc ccatatctat tttctattgc tatttttgct 117000 ttttcatatg ttttatatag gcataaacat tcttctttcc agtgtttaga gaataagcca 117060 ccatggttta ttaatattcc ttgaaaggct aaagtatttt tacgaaaaac cgcataaaat 117120 tccattaaaa ctctccacga ttaattgaaa tttatttcca ttttcgacct ggttgccaat 117180 ctgggtgact aaatctaaaa tcgtttggat ctattgtaga tgcaagtttt ccggatttat 117240 gaatcaacca ttttcttgac ttggcagctt tagaatagtt taatttggct tcatctgtcc 117300 ggatttttcc tttgtttgct ttagatattc tttcacccca ggttttaact tcttcaggtg 117360 aaagaatatc tcgtaagtct ttgccataca taggattatt tttacctgca aaactaattc 117420 cgtttgccaa tctggttttg ttagatttac cagtcccagg aaattttaaa cctttattcc 117480 aaggttgtac accagaatta tatctatttt tttgtgcttt tgaaattttt atttttgttt 117540 cttcttttat cgaattaaca tttaagccag ttttgtttat ataatcccac ccaccagaac 117600 caccaagttt gatattgtat gtatttgggt tttttataaa atcttcatta acaatttttg 117660 attctagata aaacgcttct tctggcgaat tgcaaatatg tagaacctct tttataaact 117720 gggccctacc atatttatct atcgcatttg ataatatctt accagaacct aaatactcgt 117780 catttggatt cttggtttta tgaactccaa cataaatctt cgaatttacc aagcaggttg 117840 ttttataaac tgtatacaca tcactcatga gatctcctta taaattataa aactatttat 117900 aaggtcgtct gaggcgattt ctaactaaaa gtttcctgtg ttaacctgcc aacattctaa 117960 tcccaagatt cgccacatat caacaacttg ttgacgatca tctaaaacat aaagaacatt 118020 atacctattt gcaatgtgtt tgtaaaacaa ttctttctta acaatagaat cttttctgtg 118080 atctttatgg ctacgcataa taagcttaga atattttacg ccgtgtttgt taagccattt 118140 ttcggtccct aaacggtgtt cttgttcttc gccttcttca cgtccggaag tcaaaagaac 118200 ctcaacaccc atatcataca tcatatttac gtgattgata acgttttggc ggggtttgtc 118260 tttatatagc ttataaaggt cataagggct tctatgatta ttatcggcaa tagttccatc 118320 gatatcaaca ataattgctt taggcagttc taaagttttc gaccaatcag gaacaccatg 118380 taaataatgt tgcatttttt cataaaatga ataaatcaca gaaggaggaa cagcggcttc 118440 accacgataa aggttacgtt tatataatgt ttctagatct tcgtcgaatg agacataatt 118500 gatttgccaa ttaaacgtag ctgcaaagtc ttcccattta gtccgtgttt ttggatttaa 118560 gtttgtatcg gaaataatga caatgcgatt accaggttga tttagccatt ttagtgcaag 118620 aagttgttgt ttgtctgtga cttgttcttc acgttgtctt gtcggtttgt attcattacg 118680 tttacaatca aaaatttcac aacgtaagtt atctctatta agatctaaaa caacttcagg 118740 attagcatca accatttctt tggcccaggt acttttacca gaaccaggag caccaacagt 118800 cataataact tgtttaacga attcgtcttt aggcttagat ttgtcataac ccaaataatc 118860 taaggtcttt tggtcttcaa tattaaccca aataatctca ttgctttgtt ctggtacaaa 118920 cataataaat ccttatttaa tcaaggttgc cataaatgtt aaaaattgtc cacgaacaga 118980 atcctggtca cgagatattt gtgcattctg ggtaggacta taatcagatt ctgattcagt 119040 tcttaaacaa tatcctagag tttcatattc tctaaaaagc ttatataatg tgtcatattg 119100 ttcttgggtc attttatgtc cttttcaata gtttcgatag ttaaataaac tttggattta 119160 attggcgtaa ctgttttacc ggccttttta aataattttg ttgcttggtc cgggtctgtt 119220 ttatatagat tcttggcttc ttctttaatt aaagtagctt cttctacggc agacataagc 119280 tctttaattt gacgacgaag aacttcgata tcagaatcag ggttatgagg aacaaagtca 119340 tcttttaaaa ccataaattt accccagtgg gacttttcta ttaaaggatg acataaaacg 119400 atatctttct caatcaattt attatcgtat gaattaatat attgtacaac taccttatca 119460 ataaaaggat cgttaggatt ttctaatata aaaaccggtt tatatttcgg gtctgatcct 119520 ttagaagaat taaattttaa gtattgtttt aattctgtat cacgaattcc ttcaatataa 119580 gaagcatcat ttactacata ctctggtaaa atttcagcac caatgtatcc aatatctaca 119640 cttatgtggt ttcgtgacaa tgatgctaaa ggtgtattaa accctgtcat accaacaaat 119700 tcagaatatt caatcattat cgaaccatct tcaagagtgg cattaacaat aacagggaaa 119760 tctaaatttt taatagaacg atatccacaa ctgtttaata atttaacttt catttaattt 119820 ctcacatttg ggttcattta actcaacacg ataataacat accatagttt tcatttgttg 119880 taaatatctt tttacgtctt caagccaaat tcttaagtct tgagattctt tataagataa 119940 agcaacttgt ggaccttctt gattaatcac tttccaattg acatctattg gagataccgg 120000 agcaggccat tgtggatgaa tttttggtac ttcaggactc acaggaacaa cgctagcgca 120060 tccggttaat aacataatag gaattatcaa ctttttcatt gtgtttcctc tactacacta 120120 tctgtgaact ttttaaatga atcatttata agtttagata ctaaaccggg cttggcttct 120180 acaacatgtt ctctagaagc atccttcttt aacttataag aaatagtatt tgtttctgat 120240 tggatagaag caaatttctc gtttaaagta ttatactgtt ttatttgaga atctaatttt 120300 tctttatatt gattaaaaga gctttctaat tctgtaagct ttttttctgt ttggtctaac 120360 ttgacagaat tagtagaata taaatggtaa aaaataccat tacttattac caggacaaaa 120420 atcccagtaa tcatgtataa ttttgtattc atcgacataa cttaaaaata gtgttaatga 120480 tatcatcaga agataaccct ctgaatagaa tatgatttct tgatgttgaa gagctacaac 120540 taaaagaggg tatttcagaa gccatatcat cataggtcat atttttatgc ataataccta 120600 attggtgttt ttcataaata gggtctacga taatataaca tttatgcccg ttgatatgga 120660 cattaggctg ggaaatatta ataaaaattt ctgcacctgt atttgctaga taactttcta 120720 aaaatgattt catttcttgg acagcttctg gcattttttc acgtctttct tcagaaatac 120780 ggtcattata ttctttctgt ttagaccgtt tagaagcctt acgtgatata gcagttctta 120840 aatctgaaag atatccaact tttttagaac ctttgtaaac ccagataccg tcatgacgat 120900 caccaaaagc tgctactaca gtttcgtttg taatttgttg taaatccatg ttgacctctc 120960 atttttaatt tttaaatact ataatataaa aacgagaggg tgtaaactac tttttataat 121020 tttctgggac aaaataactg taatatttga caaaaaggct atttaatatt gaaaacaata 121080 catcataatc aaatccgtta tacattttca tgtaagcaga aaatacttgt ggtataccaa 121140 gtttattaaa ttctgcttgt ccattgacag catagtcttt tctgtcttta ccaagatttt 121200 gttcataaac ttgtttaata ttttctactt gagaatgaat agccttagta tagacttctt 121260 caaaagtatt aattttatct aaagccactt ggtcattagc aaataatgat tttagatcat 121320 ctgaagtacc ttctacaatt gctttaaaaa gatcttcatt tgatgtaata gaatcttttg 121380 ttctatgtaa agaaacatag gcatggcttt ttactttaaa tttagtccca tctgacatct 121440 gtgcaactac accttcaatg ccttgtgatt cgtaaacttt gtctacccat ccttcttcag 121500 gttcatatct agtaacaaga ataggtttta gttctttgat agaatttaaa tcgttataat 121560 caatatattc acctgtttca ttatgacgtg cgtttaataa aattaaagcc ggttcagaat 121620 aagaaagaac aatgcgattt gttggagcaa catattcaaa attgaaagta taatcaggat 121680 tatccttaat tacttttctt acatcgctat atgtttctgt attaatcaat ttacaagctt 121740 cctgggcttg ttctgatgtc acggaccctt tagattttaa ataaacaaat ccatctacaa 121800 tataagaact aattaaagac ccatctgctt tatccataag atattctacc ttagaaaggt 121860 ctaaattcat tgtcattggg ttttcattta aattaaaaaa tttctccatt ggtctagaaa 121920 gaattttaat aggatttcct tctgcgtcaa tttcaaacat gataccacga cactctaatg 121980 catcaggtaa aagccaatcg gaatatgatg cgtagttata attaaaaatc cgagctttat 122040 tatttagact taatgacaca tctacataaa aaaacttggt tctatcatac tcgcataaag 122100 ccatcaaatt gtcaaatagt ttcattcttt ttccttatgt tgtgtattcc aatcaggatt 122160 aaacatttta ataaaaattg gctcttcaag gtccatagta cttatttcca tttgccctaa 122220 atcattttta gccactaagt caaaacactg acgataataa aatattacag atttaccttg 122280 atttaaagaa tcatagatat ttttagattt agtggaatct gaagtccaag tttgcctgtt 122340 catggaagtt ctgtaataat ttatcctctt tctaagattt ttggttttac caatgtaaac 122400 taattgccca tcaacttcta tagcgtatat tacatttctt tttgttttaa gctctaatgg 122460 aataggagat atttcattat tatctaaatt aagttctaaa tattttacaa atccgaattg 122520 tttaaatgac atacatataa agggcctaag cccttctcct tataagtatt tcttaaatcc 122580 atctaaaact tctggattaa tatcttcatc aatttgagaa attaaataag aatcgatttc 122640 aacttcttga ggcgctgatt gaacaccttc agaatttaga tatttagaca tccagactaa 122700 aggattttta agacctttat atggactatt taatccagca tgacgcattc ggatatcagt 122760 aatataatct acgtatcctt taagatttgt gtgatttaaa cctgggaccg taccaaattt 122820 aaataaatcg tcaacccaat ctttttcttg ctggtttact tcaagaaata acttagtagc 122880 ttcatctttt aattcttcgg cgattctttt ccaatgttcg ccttctttac cggattgcca 122940 ctgtctaatc atatactggg tacctttaag atgcaattgt tcatcacgag caattaattt 123000 cattatctta gagttacctt ctagaacacc tttattttca aagaaattaa atgtacatgc 123060 aaaagaaaca taaaaacgaa tagcttctaa agcattaatt gcatgcatgc atagataaag 123120 tttacgcatt gcattatcta agtctttttc atatctgctc caagcgccta aaagtggcat 123180 tcctgtaggg tctctttgct cttcttcaga aattaaatct tttatatttt cgtattctct 123240 aattgcctta ataagatcat cataatattt tgtaatggat tctgctcggg ccataattgc 123300 gtcatcaaga acaatctcat caaattcttt tgaagggtct tcataaagat tacgcataat 123360 atgggtatac gaacgagaat gaattgtttc actaaatgac caggtctgaa tccatgtttc 123420 taaagataca tcggaacaaa tagataataa agcctctgaa ggacctctgc cttggattga 123480 atctaataat gtttgatatt ttaaattatt agtaaagatt cttttttcgt gttcaggtaa 123540 tttgtcatat tgtgccttat ctgtcattaa gtttacttct tcaggacgcc aaaaaaagct 123600 taaagttttt tcagtcaagt cttcaaagac ccgatgtttt actgtttcgt aacgtgcaat 123660 acctgtggat tcaccaaaaa acattggttg ttccataata ttgatttggt ttttattaaa 123720 aatgctcatt ttaatcctta attctctttt taaccactgt attatttttt aaagcatttt 123780 cataagcagc tttaatcaat tttaatcttg tagttttata ttctttaata ttatcaaaat 123840 ctatcctggc ggagccagga tattgattat aatttacatg attcgcagtc agagtctttt 123900 gattcatctt ggttatttcc gtcattagta ttatggtaat acattgtttt tccacctaat 123960 gaccagaagt ataacatatc atccatgatt acgctcattg gtaccttaga tttttcataa 124020 atacttgggg tgtaataagt attaacagaa atactttggt ctacaaactt ctgcataata 124080 gcagcttgag ttaaataacc tttcattccg cgtttactta ggtcccaggc ataatcataa 124140 agatcttcat taaactcaat attaggaaca acttgattaa acgacccgtc tttagaagct 124200 ttagctgtta cagattttct tggtggctca ataccatttg tgctattaga aacttgagaa 124260 gatgattcac aaggcattaa tgcagataaa gtactgtttc tgataccgta ttgcttaagg 124320 tctttacgta aagattccca atcacataca caaacaggtt taactacttt atcaagattc 124380 ttattatacc aatcaatagg taataagcct tgagaatact tagtttcgtg ataaagttcg 124440 catggacctt tttctttagc taaatcaaca gaagctctga ttaatgcata ttgtagtcgt 124500 tcaaataact catgagtaaa ctgttgtgca ttatcataat ttaagaactg agaagctaaa 124560 gaagcagcat aattagttac accaacacct aatgcacggc gttttttagc aatcaatgct 124620 ttttctacag gataatcttg ataatctaat aaagcatcta atgctctaac agccacacgt 124680 gcaattttat taatttgttc ttggtcttga taatcaaatg aatcaagtac aaatgctgat 124740 agagtacaaa gtgctatttc cccatcatct ttactaatat cactcgtggg cagacagatt 124800 tcggcacaga gattgcttaa tctaatagga gacgtttctc taataaatga accttgtcta 124860 ttaacattat caacaaagaa cggatagatt cttgctgtat tagcacgctc tgttaataaa 124920 atagaaaata cttcagatgc cttgattcgt tttttacgaa tagaagtatc tttttctgcc 124980 gcttcgtata aatcacggaa tttctgttcg ttactaaaat aagcatcata cataccaggg 125040 atttcatgcg gactaaacaa tgtaatataa tcatcattaa ttaatcgttc aatcataagg 125100 tcattaattt gaacaccata atctaaatga cgaatacggt tttcttcaat acctttatta 125160 tttttaagaa ctaacaattt ttctaattca aggtgccaca ttgggtaata taaagtagca 125220 gaaccacctc gaatcccacc ttgggagcat gattttacag aagctaaatg ggttttccaa 125280 aatggaatca caccagtatg gacaacttca ccaaatccaa ttttagaacc ttcagcacga 125340 tacatcccag cattaatacc aataccagct cttttagaaa tgtattttac aatagcagcg 125400 tttgtttcgt taatagaatc taaagagtct ccactatcaa taactacaca agaactaaat 125460 tgtcgtgttg gcgttcttac accagataaa ataggtgttg gcaaagacaa ttgtttatct 125520 gatacaactt catagaattc aattactttt tctaatctgt tttctgtttc ttcttggaat 125580 aaacacatcc caataagcat aaatgcatac tgtggggttt cgtaaataat tcctgttgaa 125640 cggtctttaa ccatatattt agaaataagc tgcatagtac ctgcatatgt aaacttaaaa 125700 tctttgtcat ggtcaatgta tttttctaat tcagaaattt cttgagctgt atatttagaa 125760 agaatttctg ggtcatataa tcctaaattc acattacgag agattaattc aataaatgga 125820 ataggattag attggtcata tactttttta cgtaaagcaa tatgttctaa atttgatgca 125880 acatattgat aatctggtgt ttcttttgtt atattagatg ctgcaacttt gataattgtt 125940 ctctggattt gctctgtggt catgttatca ataaacatgg gcctagcaat ttccatcact 126000 tcatatgggt ccaccgttgt atttctacat gcaatttcta gaacattaat aattttagat 126060 tcgtcaaaat cttgagttac acccgatgat ttaattactt tcatttttat cctttctaat 126120 tataatattg atctattttt ctaatatggt tttgaataaa cgaacttaat atagatgcca 126180 attttataga attttctata ttgtagcata tcataatctt tttatcacac gatgctaaag 126240 aaaacatata aagtagttct ttattttcgg aatttaaata actgacaata gatattgcag 126300 aagaaaaatg tttagtgttt tggtcatctg ataaaaattc ttttatacat atttctgact 126360 tagattcggc atagtctttc caagtatcta aatatttcac aagcttatta agtttagttt 126420 tataatgtgt cagaatttta tctgtattag ttttattagg gcttttaccg tatatataaa 126480 aacttggagt atgcaaaata atatatttag acccaaaatt aaattttata gacgatacta 126540 aatttatagg cctattttta tttcttatct ttttatactc taaagaaatt gtttctgtta 126600 aaacaaccca ttctgattcg ttgatttcat aaaaatcatt attagatatt tctatagaat 126660 tatcagtttt attaacatac ataaaaatct cacaaataaa ttttatcatt aaacacttta 126720 ttaacaactt cggctattat atcaccatgg catggttttg gcgaacaagt gcaaccaagt 126780 cttgtacctc ttaaaacttc gagatgagac ttagttattt gtccagattt tattttgtta 126840 agaaaatatt gcttaaattt ctttatattt tcttctctag tcccatcttt aaaaggatta 126900 ccgaacatag ttccacgttg aatattaata tcaaagtcag aattatattt attaactact 126960 gtacagatca ttccaaaaca accattataa caactacggt gacaattata atcaatacta 127020 acggatccat tatatttcct taaaccaagg ttgagtatct tcatacaaaa atcctgccat 127080 caaacagata acaggaaacc aaataataaa agctaataag tattccatat taatcctttg 127140 ggcccataaa agcttttaat gtttctttaa gttcatcaat cctaatgaat tcattaaatt 127200 tatctttgat atctttagat gaagatatac aatatgtgtt acaatctata tcatgaatat 127260 attcgaattc tacacttgca cctgtatatg caaaaatatg caatgaagac catgcattag 127320 gattaaattc tactatatta tctattagat ctacgtcata aaggtctttt agtttatgca 127380 aatctgaaca aagggattca atagaatccc aaacacctaa aatcttttca ggttcatcat 127440 aataggcttg cactaaaaaa ttcataataa atcctataca ctaaatgggt atttaattgc 127500 agggtgatat tgataatctt gtatctcaaa atcatctacg gtcacccagg tttcaatatc 127560 ttctaaagat tgaatgttat cattaataat aagttttggt gcctcaaatg gctctctaga 127620 gatatgttct gggactaatt taagttggtc ttcataaata tgagcatttg taattttatg 127680 aaatacacgc ccaaatttat taccagtaat ttgtgccatt aagcgtaata aaacgtaaca 127740 ctgtaccata ttaaaattta atcccaatgg gacatcacat gatctttggt atgaagttaa 127800 atataatgtg ctattaacta aagaaaaatt atgagtatgc atacatggac gcaaacatcc 127860 tagatcaaat tcacctgggt tccagaaagt aataatttct ccacggtcat caataccttg 127920 gcttaaatta tcatatactt ttcttagttg gtctacagaa ccattccaag aacgtccttg 127980 gacaccgtaa acacgaccca tatcatcggg tcctttacga ttagggttat ttaaccatga 128040 ttcgttttca tttgcatttg cattccatgt attacaccca atctcacgaa attgtgcagc 128100 acttgaatat ccacgaagat atcctaacag ttcagcaata gcagctttat aaaaactttt 128160 acgtgtagta tcaataggaa attcagaata ttctaggtca gcgttaataa taacacgaca 128220 aaatttacct gttcgtttat tataaacatc ctgaccttca ttataaattt ttttcaataa 128280 tcgttgatac tggtattttt ctaaggtctt ttccatttat tatctcttac ataaacgagt 128340 tgtttaaatg ataatttaag ttggtctaaa tcaacttttg catcaggttc tgcgaattct 128400 aattcaccgg tacctaaaag cttaccatca acccaaagct ctataagtgt gatatccgaa 128460 taattttttc tagagtttaa aaagtttttt acatcttcta aattagtaaa aactcctaca 128520 tttctaccgg attcgcatat attgacatca gtaacaataa gaatcttcaa catttttatc 128580 agccaaaaca aaataaattt gctcaccttg tttaataaaa tatccgtaca tttttagttc 128640 tgttccttga acattaacat atccttcaga aacagcttta gttatgtcaa ataatgtagt 128700 acgaatataa accaagccat ctttagttct aatgcatgta catgatgaat tttggtttga 128760 gccaagttct tttatatcac atgagatttc ataaatacca tgtggtattt ctcgttcttg 128820 gcaatttcta taattagact taaaagccct taaagaaaca gaatctaaaa agaatgttct 128880 tgaaggaggg gctttaacta atttccatga acatattggt tgtacaaact ttttatacaa 128940 tttaatttca gccattattt aaatcctcat ttattaatgg ataaaggcaa ataacacgtc 129000 cgttttttct aaaaattcct tttactgtaa tgtggttatt ttcaatttta gtgtggcctt 129060 gactaataga tttaaatagt cgtgataaac atgtatcaac tttaatacat cttttatctt 129120 taatgtctga tgtttttaaa tataagtcat gcccattacg taaacattct ctatctattt 129180 tccaatcttc taattcataa acaccatgtg gcataacttc cacatattct tttcgtaaga 129240 ggcttttata ctcttcaata gtaaggtctt taaaatataa gaaattggtt tttggtgctt 129300 caacaagtac ccatttaaat ccggtctcta aaggtcgaat taatttcatt tttggtctct 129360 tatcaaatga ttttcttcta tgcagtcatg gcgattaagc atgtaaatat gttgttcgat 129420 tttcttaaaa tttctcagtt tatctaagtc aacaaataca tcactctggt aaatacaaga 129480 ttttttaatt tcagtccaaa taactttatc acaaaaatca aatgaagctt caattaatcg 129540 tttaccacca ataatagata ctaaattttt taattcagga tttcttgtaa acatttcaag 129600 ttctttacaa acttctttaa gtttattaga atcccaaggc ccaataattt ctctatctgc 129660 agatttgcca tctaatgata ataaaggttc tctaggatca tcaaccataa caatagaata 129720 tcgatctttt aatttaggca tagccataaa agtttttggc cccataacaa tatatgaacc 129780 cacatcagtt gcaggattca ctctaggagc aattgttctg gacttaaagt tatccatatc 129840 ttgtttaatt cgatcccaag gaagtccacc cttaagtcct atgccatatc cttttggttc 129900 tttttgggtg gcaaaaattg tctgaatcat aattcacctc attaattttg atatctatag 129960 tatcatgata aaaatctttg taaatatttt ttcactaaaa acaaaaaaag gaacccgtag 130020 gttcctttta agattaaatc agatcattta agatatcatc tacagattgg tcacttgtag 130080 aaacactttc acctaaatca acggaatcat taaatgcatt catttgttta gaaaaatcat 130140 cttgagcaga taaattatct aattcggcat caatatcagc tgaagcacta gaagcagaac 130200 ctgcaaccat acttacaccc ataacttgtt taaacttagt ttcaagttct gcatatggtt 130260 taaactggtc tttagctacg attgtttgta aatctacaca ttgatcaata attgatttct 130320 gtacagcttc atcatcaata ttaggaattt ctgattgagc gtagaattta caatcatcat 130380 aattagggaa accacttact tttttaactt taagagcaaa gttagcacct tcaaaaggac 130440 agaaaatatt aaccggagtt tcgcccattt caatatcaac gttggccatg gcatcaattt 130500 tatccatgat tttttgacca aaccgatatt taaatacttt accttcattt tcaggagaat 130560 tagggtcttt aactactaaa atattagccc aataagaatg tttacgttta atcagtttat 130620 attcttctgg attagtatta tatgagtctt tttctgatag atatttacac actgggcatg 130680 attcataatc cccatgggta gaactacaat tattgatata ccatttaccg tttttcttaa 130740 atccatgatt tgttaattta acaaacggag tagcattatc atctttagct ggtaaaaaac 130800 gaattactgc gttaccatta cctgcggcat cagtttttaa tttccattcg tttttatctt 130860 cagattggaa accacctttt aagccagcta attgttcttg aagttctgtt actgatttac 130920 gtttaaacat atttttacct tactttattt tacagtttta ctttatttac tttaatactt 130980 acatgcattg attgtttcta caaaaacttt ctttgcagtt tcactatcta tttctagaag 131040 ttttttgtat gcatttaatt tagttgaata agtggaccaa actaaatcat tagaacattg 131100 gtcatgttta tttataatac ctaaaaatga atcaagaaga ataaatgttt cataaccaat 131160 aatattggat tggagaagtt tgaatatata agatgtttgg gtcttagtat tatattcaaa 131220 tatctcttta agcgtttgaa catttatttt tttagaaaag taataaatat ttttaaggtc 131280 ttctttatat acttcagaaa gaccttgtaa tttacctaca tattctcgat aaaatactaa 131340 cgcatctgca tctgatattt cacctatcca tgcatcttgg tttgctacta aattagaaat 131400 aaaaatataa acaagttcat taagtttata tttatcagac aacttttcaa aaaaatattt 131460 atcacgacgt ttattataag ccgcatccga tatacgcata acccagttat atttaattac 131520 atcgtattta ccattcatat gattttttaa catcagatat aattggtata cacttttacc 131580 ggtgatatat ttatttgaat tagatggaat acggacttta atcataatat taaaataaaa 131640 aatctaatgt gtttaatgtg aatgttttac gaacagaagg tcttaattca ttgttttcta 131700 aagcttcttt agtgatctta tcaattattg cagctggtaa atatttggta catagattat 131760 atggaataga attttcttct aaccaattag tagaagcttc tatataagaa gctccttctt 131820 taactttttg ctctattaaa gctccaacaa tagttgggtc ttctatatca atattaatgt 131880 tttgggaaca aagagtcata taaatctaat gcctcatcag tttcggcttc aaaacgttca 131940 cgggtttgtt tatgataaat tgcaaaaata cgtgtccaca ttttagaatc tacacctaat 132000 tcatctttag cttgattttt aatatcttta attttttctg catatccttc catgatagtt 132060 ttttggtcag acgcttcttt aatcatagct gctaattttt caccatgtac tgcttcatca 132120 aattcaattt tttctttaga cataattacc tctaaaacat gttaatatct ttagttaatt 132180 taactaatcc agcctttaca aaatatggat aaattttact tcttccaggg actttaaaat 132240 tatcaaattc atctataatt ttttgtttaa tatcctctgg aatacaagtc atatctatca 132300 taatcttatt ttcattaaag cgtttaagtt cttcttctga aaggtgtttt tctggtccat 132360 catctaaaca tgactggatt aatttagtag aaatacttgg ggctctttca ccttcaacac 132420 gagtaaacca ataatcagaa cgacatttaa caccggctac agtatctttt ctatctcctt 132480 taaggagctt tgtcattaag aattctggga tagattcttt tgatttaacc attttcttaa 132540 gttgtggagc ccattgttta atattattat taatatgcaa ttgtttgtag tcaccatccg 132600 aagaaataat cattattttt ctatctaaac attctctaag agtaagaacg ccaataatgt 132660 catcggcttc aactcgtgga atgtcaatag tataataagg catattttct ctgaattctt 132720 ctttaatttg attgatagca gtaaaatatc cttcccaatc aaaagtagaa ttctcatcac 132780 gatctgcggc ccgtgtcttt ttataataat agccgtaatc tcgacgccaa taaccattgt 132840 tagcattatc aaatgcaaga actgtaatag gatattcgtc attaaatttc ttaagattaa 132900 atcgaatact atttaataca atgtgtctta acatcccaat cttaattggt gtattctgga 132960 attcttggaa tgctgcggct aatgctattt gagacatatc aaagaattta attcctggtt 133020 tttcatcttc ttcgtcgtca aaaaatgcac ttaaattaac ttgattcata aaccctctaa 133080 taaatataat aaagaaagga gccatatatg actttaaaca aatcacttaa agcaacatac 133140 ggacttgatg cctctaacga aaaagttata aatgttggac tagccgacaa aaaaacttta 133200 acagatggcg ttaatgtcga atttttaatt caagaaaaca caatccaagc atacgacaaa 133260 aaccgtggat atgaaaaagg ctttgcggtt atatttgaaa atagaattta tgtttcaaat 133320 caaaatatag aatcacctgc aggtgatttt gagcctcata aatggttttc tttacgtgta 133380 gaccctaaat gggaaacaat attcgaaacc gtgtcttcag gacagattat aacatcagga 133440 caatttattg cagctaatac ttcaataaat gacctttatt ttaaattacc tagaaaacca 133500 caaccaggcg atactgtttg tattaaagaa gtttctggta attcaggtta caaatacctt 133560 aaaataggta aaactgataa ttccattatt tggaatggga cagatgttga agaattatat 133620 ctaacaagac cttattcgca aacttatttt atattttctg gtaatgtttg gaatgtattt 133680 caaattgaac acgaagatat tggaagaatt atatctacat cgccaataaa gcagcaggtt 133740 tctgctggtg aaagactgta tagattatct tcaacaggcg aaattaatat tatgttacca 133800 aaatatgcta tgcatggtga tgtaatagaa atgtttgacg ttgacgggtt aacatcaata 133860 aatcatttaa caatttttgt ttcagaaggt tcaggacatg ctattggaac actagggcaa 133920 actaaatacg aagttagaac catcggtaac ggccgtttag tatttgatgg ctctaataat 133980 ttatggagat tatgggatgg tgatattaga acaagattaa aaaccattaa agaagaccat 134040 aaattacttc ctaatgagca agttcttgtt tatggggcaa ataatactgt taaagaaacc 134100 atcacattaa ctttaccaag aaatatagca gtgggtgata ctgtagaaat atcattagga 134160 tatatgagaa aaggtcaaac agttgtcatt aaaaccgaag gcggggatat tattgggaca 134220 gataaaaatc ttttacaatt cccaaaacgt tcacaatatc caccagaaat ggcttgggtt 134280 gaagttaaag aactgacatt taatggaacc gatgattatt taccatactt aaaatttgca 134340 tacgtagaaa cattatctaa acttggatgg gcagttcaac attatcgtcc taatgttgaa 134400 agggttgatt ttaaaaatcc agaaagaatt ggattaattg cattggccac tcaaaatcaa 134460 gctaatattg atcatgaaaa taacccggaa aaagaattag ctattacacc atttacactg 134520 gctaacagag ttgccactga agaaagacgt ggtattgcta aaacagcaaa atcttctatg 134580 gtcaatcaaa actcaaatgg aaaatttgaa gatgacacta tagtcacacc taaaaaatta 134640 aacgaacgaa cagctacaga agaacgacgt ggcctggccg aaattgctac tcaagaagaa 134700 acaaataccg gtaaagatga tacgactatt gtttctccgt taaaactcga gaacaggaaa 134760 gcctcagaaa ctttatctgg tattgctaaa atagttccat ccaagggagc cccaggaaca 134820 caacgtgata aaccaggtac aggtgtatat aattatactg ataataccac aatagtttct 134880 ccttctgcga tacacgaact tctaagtaca gaaaattcac atggtgttgt ttacttagca 134940 tctgaaactg aagttattga agcaccagat atggacccta aatttcctgt tgctgtaact 135000 ccggttcaat tacataagaa aactgctacc gaagatagaa ttggtttctc tcaaatcgct 135060 acacaagaag aaactgattt aggacaagat aattttaaat tcataacccc taaaaaatta 135120 aatgatagaa aatcttcaga aacgttagaa ggtatatcaa gatatgctac gtatgaagaa 135180 tttaaaaagg gtgatttaaa tttaatttct gaacctggta aaataaaaca atttttacaa 135240 gaagcaagaa taacaactgt tcctgaatct ggaattgttt ttacaggtaa tatttgggac 135300 acttgtaatt ttgatattaa ggcttcgtct gaagttgata gaggaacttt aaaattatct 135360 acacaagacc aaactgatac aggtgaagat gatacaactg ctattacgcc taaaaaatta 135420 caaaacaaaa aatcaacaga acaagttgaa ggaattatcc aactttcttc ttatgccgaa 135480 acaattgcag gagaaattaa taataaagca atttctccac aaaattttgt tttagctgta 135540 caaacagaag ataatggttt acaagcttca acttctttac gtggttttgt aagattgttg 135600 gatggggcta gtgtatggca aggaactgac gaaacaggta gtgatccaga aaatgaagac 135660 ttcttacatg atggatatgc agtttcacca agagaactaa acaaagcttt aagtcattat 135720 ctccctatta aaggcaaagc cgttaattct aaattatttg acgatttaaa aacttctgat 135780 tttattagaa gaaacattga ccaagaaatt gatgggacca tgacttttaa taaaccggtt 135840 atacttaaag atacgttaat ttctgaaagt tctggcaaat ttgagtcttt agaatcaaaa 135900 acggtttcta ttggcgatgg tactattggt tcaattgatt ttttatctac aactaaatgg 135960 aaaataaatg tccaagatga tttcaaaatc aatggtgtta aaattgataa agatgaagtt 136020 atccattcta aaggattaga aaccgtttct tatattgata cttcagaata tagattaaat 136080 ggtaaaacat ttatttctgg acaaggcact attaatgtag gtgatgctga atctcaaatt 136140 agattccaat ccaaaaatcc taatgatgta agaatttctg gctctacaat tattgttaat 136200 accaatttag aagaaaaagg taataagcac tttattaatc gtaaacaaga taccgttgac 136260 ggagatattg aatttactaa acctgtaaaa attaatatcc cagaaaacat ggttgaagtt 136320 tctgaaggta tatttgttgc taaaattact tctaaagaag aatatgaaaa atatccaggt 136380 atagcagttc ctaaaataga ccaagaaaca cagaaagtta ttgattatac ttatgttaaa 136440 ggacctggta cgttaactca gtatggcgat acaaaatcat acacatacag aatctgggct 136500 cctcaagctt taggacagga agataatcat aataactatt ctttatggat gcaggtttat 136560 aacccagtta aaggtgaatt tgatgcatgg ggtagaatat acacatctca aaatccacct 136620 actgctgcag aaataggagc tgtttcttca tctggttcta ctttcgaaac acttaaagtt 136680 aatcaatggt tacaagttgg acctgtaaga atggttccag acccagtaac taaaactgta 136740 aggtatatat ggatcgatga gtaatataat ggttgaattc ggccaagatt atgtgggtgc 136800 tcaaacgttc tcagagaaca atgctctcac atataagtta actataaggg ccagtaataa 136860 aaacacacag ggtgaatcct gtgtgttaat taatgataaa aaaatatcag atcaatgtca 136920 aaaaggattt aatgtttggg ttatagataa taaaggtaat ttactcaata atatggtctt 136980 cgattttaca gaagaatcgg gaagaaatgc ctttattgat ttcatgaaat cccaagataa 137040 agatataatt tgtattagtt cttctgatga attgttttct tcggaagaac tctcaaaata 137100 tatgaaaagt ataggttctg cttcatggaa tgatttttta attaaaaaga ttaaaactgt 137160 ttcttatgca tgtgtatata gaacagatat aaagcaaata gtactagaat ctatccaata 137220 ttcagatggt ataaaagaag ataatgtttt agaattagaa actatttttg attctgagta 137280 ttctttaggg ataactggat ttcctggttc tatagtctat gatcataaag aatatacatc 137340 agttgaaaaa gactataaaa aatggcctac taatttgttg aataataaat tatccgatta 137400 cggtcttaaa ccaggtgatt gggtttcttt aagtgcatct atattcggtg ataaagagct 137460 taaagacgaa ggtggttgga caaggataga ttgtagatgg gttcttggca atacatggaa 137520 acaatcgttt tatcttgaaa gcacactaaa aggcagttat ccagttcaaa ctatggtaaa 137580 tccggatatt tgggaatcta aaacagttta ttctcaaata ccagaaggtg tagatggctt 137640 tgttattata gcaactagat ataattcaga gactggctat tctgctgtaa aaaatgttgc 137700 atttggaaaa tcagcagaac ctataataga agaatccgat cgacaaatag ggataaatgg 137760 tatcagaaat tcatttataa aagaggaaga acaaaaagta ggttcattat taagtttatt 137820 aaatcttaag gacaaatccg atacaatttc ttctataaac tttaaagaaa tctaataacg 137880 tatagttatt aatttattac ttaatagtta tatagaatat actatacttt taataaaata 137940 gtttactata gttattaatt tattacttaa tagttatata taatataaag aacttaataa 138000 attctgggag cttcgctccc agttttcttt agaaaaggct cttttataaa tacaataaag 138060 aaaggagttt atatggcaga ccttaaaaga ggaagtactg ctggaggaga attaattctt 138120 acacaaggaa attttccatt aataccagtt ggtaattctt tatattttaa tacacataaa 138180 gtctacactg aacatgataa gcctacagca gaagaagttg attctgtttc ggcttctaaa 138240 ggtggagaat ttaaagaaag agtaattttt aaagaaatac aagttaatgg taaaacaact 138300 ccattaacaa ttaaagaagg gttagaaaca gatagcgaaa tatctatagg aacattagat 138360 attaaatcag gtgataaatc tgttttattg attgatcctt ctaatcctga attacttcaa 138420 acagattcta taaaaactaa taaaaccgtt ctaacatccc caggaacaga agccaatcat 138480 gctgttagat atgaccaagt tgtgttggta ggtgatgtta ttgactttgg agaattctaa 138540 tggcaaaaat tccaagaata caatttaaac gaactaaaaa tccaggagta aaaccttcta 138600 aagatatttt agcagaaggt gaattagcta ttaacttagc agatagaatg ctttttacca 138660 aatcaggtga agaaataatc gatcttggtt ttgctaaagg tggtactgtt aatggagata 138720 ttatccaaga aacaggaaat tttacaacta atggaaatat cagattaaaa gaatatctta 138780 acattaacgg cccagataat aaagctttaa atattgcata cgattctaga ggtccactta 138840 ttggagtaaa tgaaggcgat aataaatgga aggtacttca aatcccagct gaaaccggga 138900 catttgcatc tcgagaatgg gttaatactt ttgttaaaag tgggtccatt caaactgact 138960 taaaagcccc agataataca acggttctta ctataaataa ctcaaaatta ttatcattta 139020 aagatgggac cactgatata ttcgctgtag atattaaagg cggatatatg agaaattcat 139080 taatactatc tggacaaaat gattatcctg gtattacgct tcaaaaaaat gatactttta 139140 aagttagaat agaaactgac acagattcta gtaatacttt attggcattt gcttatagag 139200 attctggcaa ttctaataaa tttgttataa aaatgccaaa agaaaatggc gttttagcat 139260 ctcaacaatg ggtagatgga aaatattata aaagagatga ttctcctaca tttaaaggcc 139320 aagtaaatat tggagataaa ggcggtaata gcaattacgc tcaattatca tatgaatctg 139380 gagaagccag atggagtgtt aacaccggtt cttggaaaat actaaagcat cctaatgaga 139440 atggaactgt tgctacgcaa gaacgcataa ataaaatagt taaccataac ggccaacaag 139500 ttgagttgat ctctcctaat ggaactatga aagcaacact tcaaaataat ggcacattta 139560 gtacatggaa tggtaatggt aatccaatat cagttgatgc ttctggtaat actagtgtag 139620 cagggactat tcaagcggta tctacagtta cagcaagaac cgccaatagt aatactattt 139680 ttggtctttt tgttagagat aaagaagcat ttttgtctct aaacatagat aataagtggg 139740 ttggcgaact acaccatcct aagacacatg ggacaattgc cactcaacaa tggtcaaatg 139800 gtcaacatta tactaaatct gaaacctata ataaatcaga aattgatggt aaagttaatg 139860 gtagattaac tcaaagccaa gctgatggaa gatatgtcag aatggatttg actaatctag 139920 gtaaacaata tacgccattg actggtattg catctggaca atggggtaaa cctattggtt 139980 attctgttat ggttaatagt gcatcttcgc ctcagcgccc tccaaataca ggatacggct 140040 attggcatgt aattggggct agagaccaaa gcaatgggta cgccggtata tggggtggat 140100 attctgatgg tcaaatgtat tatggtaatg gtaataccgc agctacaaat cctacatggt 140160 ataaaatata tacttcaggt aacaagcctt caccatccga attgggggtt tatgccaaag 140220 gtgaagttta ttctaaggcc gaatcagatg caagatatcc tttaaaaaat gatgtttacg 140280 ctaaatcatc aacatattct agagcagaag ttgattctcg tgtaaatggt agattaacac 140340 aaagccaagc tgatggaaga tacgcataca aaggtggtgc tactggacaa aactttggtg 140400 ctaatatagt tgatgctgca gatgttaata ttcgttcaga tatctctgtt aaaagtaatt 140460 tagtatatat aaaaaatgca ttagatttat taaaaccgtt aacaggatat aaatacgatt 140520 taagacttaa tgacaatact cataaacagt cggtaggtat aattgcacaa gatgtccaaa 140580 aagttcttcc tgaattagta caaaaagatt cgacagattt attatcagtt aactataatg 140640 ggttaacagc agttcttatt aatgcggtta acgaacttaa taacagactt aaagaattag 140700 aggttaaaaa tggcagtaac aggacctaga gtaggaagtt ctgctaaagc agaaactggt 140760 ctggctagta tgaaggccgc tggggctaaa ttgggactta gcgtcccttt taaaatgtca 140820 caaatgattg gtaaaagcgt agcgggttta attttcgcag ttgacgtaaa tccagattat 140880 ccgggcaata aatacggtaa tttttctact catggaaccc caaaagggta cttaaaaaaa 140940 ggtgatactg gtgacaagct catgcaaata gaaggtattt acgccattaa ctttactact 141000 caacaagtaa tgtttattat gagtgaccct gcaaggattc acaattacac tgctatgatt 141060 attgagtata gtggtacaca atataaattg gtaccacaga gagatgcgtt agggactgct 141120 tatttcaata tggtaacaaa tgttgataag tttactgagt taatgatgaa aaatttaggt 141180 gtagaattcc aaatgaaagt tatacagata acttaatttt tgaaagttta agagaataac 141240 tatggataaa ggcttttttc taagcctgct tgatacactg tttaaagacg ccgacggaaa 141300 attaatcctt tggcgtcttc tttctatagg agtacttggg attggatgtt ttttatatgt 141360 cgctagaaat gaatttttgg aattatataa aaacactaga tacgaggctt atcagcaagt 141420 tcaaaagcaa gaaagagaac ttaaatttga aaaggccgta gtagaccaat tgcaaatagt 141480 ccatgtatcg tcagaagcag agttcagtgg aataactgaa tttagaccag ttggattaaa 141540 ttattttttt gatttaattg cttatgaagg aaaacttcct gaggaattga attctaaaaa 141600 tttaggagga tggcctgttg ataaaacatc agaagaatat attgaacata tgaatggaca 141660 ttattataca acaaccgaac attttagatt gccaacaagg aataaaatag aaaataaatg 141720 gttgttttct tgtccatatt ataatttgaa taataattat gctgggagta tatttatgat 141780 gtggcctgaa aaacctgtta taagcgaaga tagacttaac atcatctgtt cacaggcttc 141840 caggaccata ggcaggacta aataaaatta cgaatataat ctattgtatt gttgtttatg 141900 ttgtgtctga agggattcta cacaacattt acaatatgga aaatacccat ctttagaatt 141960 tttcgattct gaaaattttt ctaagggcaa tatttcttta caatgtttgc atattttacg 142020 taaaggaatt ttaatttctt tcgcaacacg tggtaaaact actaattctg tctttaaata 142080 cgtatttttg caaaatcccc caatctacaa ttgtgtcttc ttcatctaat tcaacgacaa 142140 ctccaatccg attaccagga ttagtgggat ctatattata atactcagaa tctttactga 142200 tatatacaaa atcaccaact ttaatagtca taattaatcc ttatggtgtt tacttgtggc 142260 atgtttaaca atcgtatgag tgttaataaa atcaatagct tcttgttctg taactaattt 142320 aatttctaaa gaatcaacgc cattttctaa tcgttcttct aacgggcata aagaatcaac 142380 gtaatctgtg atagatttaa tataattttc ttcagtaacg tccttttttg ttcctgaagc 142440 aaatttatct gcaattacac cattcttttt atatgtagta atagaaaaca ttataatgac 142500 cctttttctt gatttaaatt aattttatac tcaaatacat gagcataata cccgttatga 142560 atattaacaa tttctaaata atacccacca gagatttcaa atgtcatgct attaaaataa 142620 tttgatccat catcttcaat agaaaattct gctacgccaa taaattctgc cgattctgac 142680 aaatctgaca attcgacttc tttaaaccca ttattgaacc tatcattttc ttttttgaag 142740 aatttataat aagcatgttc gcaacaatgt tgtgaatcta catcaaatcc aacaaagtta 142800 tcattattat caataaaatt ggttgttttt ctttcgtatt ttttgccaca caccttttca 142860 ataatcattt aactaattcc aattcatctt tagagaacca atagatatgg ccaaatttat 142920 ctacacatgc atattgtaat ctagaatcat taggctcaat ttcatggata gtaagatctt 142980 cgccaatatc aatatcacat tctacgccaa tggtattttt aacaaatttt acagtatcac 143040 cgacagaaaa cagatcacca agtttccatc catgagactt aaatttagcc acaataccat 143100 tttttaattc cacaataaat ggatattctg catcatctga aaattcttta agtgttccta 143160 caataccatt attacagatc tcatcacccg tattaaattc atacggttca gcccaaacat 143220 cttctctaaa ccacatttca agaccactat cagtttttat ataataagga tgatctgagt 143280 ctttatccat ttttaataca tgcccggtac aatttgggct tacggtatgt ctaactttat 143340 caccgacttt aaatcttaat tcgtcattac gtttaaacat attaacctct atttaaatac 143400 atttcaatta aagaatatgt agatttatga ccggtattaa attcttcaat aagtttagct 143460 ttttcgtcat cagataatga tttaactaat gatttaagat tacttttatt aaataactta 143520 ccattattac gaatacctaa ttcgttaatg aacgctatga aaagattttc atcttcaatt 143580 atatcttcac tttcaaattt gataagaatt gagataacag caaaaatttc agataaagtt 143640 tccaatttgt tcattttgtg ccttgcttgg tgttagtaaa taataattaa aattttgtac 143700 ttctaaagat ggttctacaa catcccatcc tgataatata tccatcattc caggacagta 143760 tattttacta ttacaatata atttagaacc atccaacgta tatacaatgt tccctgttat 143820 tcttgactgt acttgaaatc cttttcttgc tttatccatt gcactgtaaa aattcattta 143880 acctcactta gaagcttcga tgactttaat catgttttct tctgttaatt taatgtccac 143940 ataataatta ttacctttaa atttaacagt agcaccaatt gatttatatt tttcaactaa 144000 ttcttctgat aatttgtagc caaatactcg catttcgcct ttatgtctaa cttcaaattg 144060 tcgaattcca ttaacacgtt tttctaaacg aagttctaaa ttacttctat tttcaaaaat 144120 acctttaata gcgaatggta gaagttcttt cattttatct gcaatatctt tcatttcttc 144180 agtaacacca cgtggtttac gggttgtttt gattttagaa ggattttctt ctgcaaagat 144240 atctgctgct ttaagaataa cttctgttcc ttgttctgtt gcaattaaac catcacctga 144300 tttttcaata aaaccttttt taattaaaac accgatatta gagttaattg aagcagaaga 144360 aatttcagga agagcttcac gaatatcttt agcttggata aaatttgttt tagcaacttc 144420 aagaagaatt gcacctgttt tttcatttaa ttctgaagaa gcttttaaaa cataagataa 144480 tttagacata atagactccg ttaatttgtt atttcgtttt gatgataaga taatactata 144540 cttaaaaagc tttgtaaaca gttattttca ataaaatgca aaaaaggaga ccgaagtctc 144600 cttgtatatg attaataagc aatttttaac ttatcacaaa tttcttttaa atactttata 144660 cgatgttctg gcaaattttt gtccaaaata attaagccat attcatcagg atggtaatca 144720 cccaagaatt tgatttgatg atttattata gcaaactgat tgatattagc atcaaaaaga 144780 tctatagttt ctgctaggcc attcttggct actaaaatat cattattatc acgctggaat 144840 aaagtagtcc acttatctgt gaaatgaggt tcttcgtgtg gtttttctgt atatccttta 144900 gatatcatca actcacgaaa tttttccata tctaatggac aaacccaata atcaatatct 144960 cttggtgggg ttttgtagta ataatctcta gctgctccac caatgatatg ataattaatg 145020 ttattgtcac ttaatatttt agaaatcatt ctttaatagt ccaccctttt ttcgtacata 145080 tctcgtttaa agaacaagaa attccagaaa tagccagatt catctttaat atccccgtta 145140 accatataca aatattcttc tggagaaaaa tactcatgca taattttatg tccatctttc 145200 atggcttcta gagcttcttt tctatccatt aaaaacatta catttctcca gcagaacggt 145260 taaaaaataa attagttttt tccataacat gattaaaaca aacatcccaa tacgaatcaa 145320 aaatagattc taatgatgaa tcgtgttgaa ttttaactga agctttacag aaatcttcaa 145380 atgggacatc aggcattgat ttaccggctg ctgttaaata aattgatgac aaattccatg 145440 ttggattctt aatagtcaac aaagatacta atgcaataaa ttgctcaaaa acttcatatt 145500 ttttaatagg tttcattgta ttttcctcaa taaattttat gtaatattat cacacttaaa 145560 agtctttgta aaccaaaaaa gggacaaaag tccctttatg cattaataga atctatgtct 145620 tttttatatt cagtttctat atcagtggtt ttccagtatt catattcctt tttatattct 145680 ttagccgcct gttctaattt tttaatttcg tctttagtca tatgataaag attcatagaa 145740 attaacttgt cagaaaaggg tttaagatta tcaaactgtt ctatagctgc taaagcatct 145800 ttacgacttt tacctgataa tacaatagtt ttatcaagaa ccattttaat aaaatctact 145860 ttggcttttg cgtaatcata caaatactcg gattctgata atttgatatc aatacgcttt 145920 tgataaaatg gttttcttat ttctacaaaa tatttaatta attcagatgc tttagtaaaa 145980 tcatctctaa ttttaccttt gtcatcaatt actgtaaaaa attgtcctat tttttgagat 146040 aaaccaaatt ctttaatgat ttgttcatga cgttcttctg ggtctgattt aagattaaaa 146100 tcttttttga tagtaatttt aaatctgaat tttacttggc ctgttttttc atcttcacca 146160 gataaatcgt catattcaga aattttaccc tgattaacta attcatctag aatttttgta 146220 gtatatgctt cgcgttccca tttgtatgga acttctgtaa taagaagttg ggttttgcct 146280 ttaagctcat atgtaccttg taattctaca cccgattcag taggaataat cttgccatta 146340 aattgtggaa actgtacttc aggttcttta tctaatttac catcaatagc taattttgta 146400 cattcaacaa cagattttaa tgaatgaggt aaaatattag tagcataacc agtagcaatt 146460 cctttaacac catttaataa aacagttgga ataataggta aataaaactt aggtggaatg 146520 tgttctacat caggatgttc tggagaaata ttaaggtctt tatataaatc aaagaagttt 146580 tgagatatac gacagaacac ataacgagca gcaccgcctt tttggattaa tctagaacca 146640 aatgcaccgc gtccatctaa aaatggaaca ttgttattcc aattattggc cattaattta 146700 ccggcttcag ccgcagaacc ttcaccatga tggtatccaa tttcagcaac accacctgac 146760 aatcctgcta atttatgata tttactttta tcacctttag ctttttccaa ggccctataa 146820 attataaatc gttggacagg tttaaatcca tctataagat ttggaatagc tcgctcttct 146880 acagtgtata aggcatattc tttagcttca ttgttaataa tgctttttaa tgaacgtaaa 146940 ttcaattcca ttatatcttc ctaatgcaaa aaggcctttc ggcctttgtt tttaaaatta 147000 aattattaat tatatttaaa agaataatta tctttaatac gagattttac ttcatacatg 147060 ttattataga tatcagtttc tgttttagct aatttaccaa ataaagttcc gtgtttacca 147120 actttattcg ttagatattt ggcattttcc atagaaacat aatacacttc aatttctgtt 147180 tttgcagata aatggcgttt taactttgca gctggtttaa atttagcagc ctggattttg 147240 ttaatgattg tatataaacc atagtttgta cggaattttt cattaatacg ttgacgaccc 147300 acagtataaa catttaagcc ttcacctgta tttttatcaa caaagaaata aaacccaggt 147360 ttaaacatat tttcatctgt ttgagaattg ataataatat caatattcca agaaccaggg 147420 tttcttgtaa gagtaactac taaatcagaa aaaccagaaa catgttgttt gttaaaacgt 147480 actttattaa aattcataat gacctcattc acgattagat agtatggatg tattataact 147540 aaaaatcctt ggatgtaaat actttaaaac aaaaattttt atctctttta attcttccgg 147600 ttaaatagta gccgtcgaat ttagatttac gaatactacc attctttgta gataaagcgt 147660 attggtctgc taaaatataa ggaatcatcc tgaatgtgtt cagggcaatc ttttctgttt 147720 tgaatataat tataatatct gccacaccaa atttcaagaa cggtcccagg tttatccctg 147780 atgtaccagg acaatctcca tccataccag aattcactac aacccattta gaatttgatt 147840 gatgggtttt tacttctatt cttaatccag agtattttgg gtgagctata acatcataag 147900 catatgtgta tgggtcttca agatcttctt gaccatgatt aataatacca tctacatgtt 147960 ctttgacata ttcttctgcc ataatggcaa tcatacattt ctcaaagcat tctggtacgg 148020 tttgatttgg gttagattcc aacgaatact ttgttgttga acgtattttt tctttagtat 148080 cttcactcat atctcttaaa gacattactt taggctttaa ttctgacaat cttttccatc 148140 caggatttgt ttctaacata ttacctctca acaaaaaaag ggaccgaagt cccttaactt 148200 atttaaatct attttttaaa cttatcagtt acatcttcta gaacagtata accacatgtt 148260 cgcattttag catcgttata atccactgga atagaaacta catcacgtgg atgaactttg 148320 acagaaacta cacggctttt acttccacca aatgatggga tataagactt ggaacacaca 148380 tgtaagccgg aagaacatgt acgattatcg tcttcatcta ctgtattacg tggaacttct 148440 acacgtttac ctggtgaatt atcaaatgta ccactatgac aatctaaata attatcacgt 148500 acgactttcc atgcaataaa atggccatct gctgtgattt cgatatctgt agccattaag 148560 aaatcataca aacgcattac agctttacga cttggattta acattaaatt ttctaagaat 148620 ggtaataaaa atttaaaatc tttaccttct ttcatattag aaataatttt acgagttaat 148680 cctgaatcaa taacaaggtc tttataatac aaagtagaac cttctatttt aatatggccc 148740 tgtgtataag acttgatagc tcgttttgta ttaataaggt ctaacgcttt ttggacatgt 148800 ttgtgttcgg ttttagaatc acctttagaa acggcttcca ttgctttaga cagttcagat 148860 aaagcatctt taaagttttc atggtcttta cctgcgttat atgttttagt tcctactgta 148920 atagaaataa acttactatt agcgttccaa accaaatttt ctaaaatatc tttggtcttt 148980 tctgtatttc ttttagaatt tttaaaatcc acatctgttg tcgatttttt aaaaagatca 149040 atgatataat tattgatatc ttctgctgtt tgctcatcag aacaattata tgcatatata 149100 gtatcttttg attttaactt tccaatacga ataatacccg ggatagctaa gtcacaactt 149160 tgtgcaaaca tatctcgttc tttaggattg ttgatacaaa ccttgtcaca tgtaatagaa 149220 gtatttaatt tagggtcgat aataatttta tctgcaaata cccagtcata tgccaattgt 149280 gaacccggct caggtgtata aatttgtgta gggttttctt ttaaaactct tgtaatagta 149340 tctggcgata cattaaaatg tcgtgcaata agagcttttg acttaccttc aacaaaaaga 149400 ttaaaaacag tttctttttg ttgttgattt aaaattttaa cggacattat aattccttag 149460 gtttcaaata agtattaatg attttaattt gtttttctgt aaattctggc aaattataaa 149520 cataataata taatacaggg tatttttcgc gaatattctt ttcagaattt tcaaattctt 149580 gttctttttg agtttcaagt aaagtcagtt cattgtataa agcttcatca gaacataaaa 149640 gtattctttt taattctaaa tataaataca aatctatagc aggcttgtat tttggattta 149700 ataaaagcat atcaatccat ggaagttctt ttagaacatc acaatttaaa aagtcagaac 149760 tatattcaac aggaatatta ttaatattta aattgaatga tttaatttta tctgaaagca 149820 tatcaatcat attttgtcct tcagaatatt taaatgctgc aggtctaata acatggaatt 149880 cttgtattcc taaaaattca caaagtttaa ttacggctct attagctatg tattgcttgt 149940 ttttgtctga acatataatt gtattatcgt atgaatataa aatgggccct ttaatttctc 150000 ggacttctga tgctgttaag tataagtcgc ttttagaaaa atacttattc catttatctt 150060 ctttcattgt ccaaatttgt acattagaag cttttggacg ggcttcaaca ggtttagaag 150120 ttttgtattt ggttcttaaa taagataaat tatagattga taagtcatca cccatgaaat 150180 cttttatttg ttctaaggtt tgtgtttctg tatcttttaa aacaacacat aatctatcaa 150240 aaccaaaatc ttgcttcatt ccacgaattg tagcaatttt gtctttacct ttacaatcat 150300 caattataac taataaatta gatacaccaa aatttaaaat tgtgctaata ttttgcttat 150360 atttagtaga actatgatta agattactaa ttctaaccaa tttaggatta tcacaaatat 150420 aatatccttg caaatataag tcaggataag ctctatattt cgagtgcaaa tttttaattg 150480 gcccaaattt tttagattca aaatattttt ttaaatattc acacaaacgg tatggtttag 150540 tatttacata tcttagaacg gccctttcag aatcaatatc gtcgatttct ttttggatct 150600 ctgtatatat ttcttttgtt atttcttcaa ctcttctttt aatattgttt accgtgtcgt 150660 cgtcatacga aatttcttca cgagaaggag caatatcaag ttcacctagc ttaaagcgaa 150720 taaatagttt acctggttca cctaaagcac ttattccgga aaagtcaaaa gattcactct 150780 ttaatggata tctaatttta cccataattg cataaacttc tgttgaatca accgataacc 150840 cggaatctgc aaaaaagtat tcatctgtag gtaaataatt aacttgaatc tgtgggccta 150900 caaaattggg tttaatgtca caaaacgtgg caaaaacata tcgtgcttca tgatgccatc 150960 tagaaacatc tttttctaaa acaggaacag ttatttctaa tccagaagga gaatcatctt 151020 caacatcaaa agtaggaatt aacgaaggtt caccattatc tagacaagct gtataaccac 151080 gggcacgtcc ttcaaatctt gatacaatag aaaatgtttc tgtatatcca aatggagatt 151140 tagaacccaa tcctaaagca ccaataaaat cattagaatc cgattttgta gattcaaaat 151200 atgtggtata catatgagtg acatcgtcat cggataatcc tggaccgtaa tcgcgaataa 151260 taaatcttgg gtcaataata gatggcaaag taacgtcaaa aggattaaaa tgacctaata 151320 aagtatgagc atctgcggca ttacagctca attcacgaat aattgctcta atctgattgg 151380 tatataaatt ttgtgacaaa actttaaaag ctttagcaga tgtggcaatt gtaaatttgg 151440 tagaagtttt attactacct aacattattt cattagtatt atgtaatttc attattaact 151500 catttgtcta ttatagtatt aatcatataa cttattatac aaggtactaa tacacgattc 151560 aatatcgggc cctttaatag agtaaaagga cccattgata tacacttcta aaatataacc 151620 catcatttca tggatagcac tttcaacaca atagaaagga gaacattccc ctttatacat 151680 tttattttta tattctatat ggataaccat attatttcct taatcaaaaa atcctggtct 151740 gtcttcaagt tttttatgaa taccaaataa tgcatcttcg atagaaattc catcttcaac 151800 aatggcttct cttctattat taaacacttt aacttgataa gcaactaatt ctacatgtaa 151860 agctgttctt tcataaattg gaagtacgac tgtccgtcgt acgcttcctt tataccaaaa 151920 ccctacttct gtcatgattt catccactct tttctaagat ctgcattatc accaaataac 151980 atttcgaata actcttcata attatcaggc aattccacta tatcgtaaac cgggtcccta 152040 acaacacgtt tatattcatt tgaagttaaa gaagctagtc ctttaatata ccgcggggct 152100 gaccagcctt ttaatttgga tttttctttt tcgtattctt ctacattata ataccatttc 152160 tgttcattac ctttttgaat aataattaaa ggtgttttac aaaaacgaat tctttgttct 152220 ttatatagtt caggccattt agcaaagaat gctaatagcg aaggatatat ggaaccttgt 152280 ccaattatct ctttatttgt gaggtatgtc aatgagtagc ccgaaggcta cccatcaaca 152340 tcggcatcag tcataatagc gatgttatca tacatcatat tactagcggt agaagttctt 152400 ttaacaatag tctgggcttt atatttagtc atatcaatat catttttgtc gatttttgag 152460 aatttcattt ttaacctcgt aatattctgt atttggtttc cagccttgtt taaacatatt 152520 taaggccttc gcatataatt tacttcgttt ttctattcct gtcttcttca tccatttagc 152580 aacaccagtt gcttttggac gagattcatc ataatttgtt atataccagt tgtatagaga 152640 ctctatatta acaatggatt ccttttcagc accaaactta ttaaaccagg gtctagaatc 152700 atttacttct ttagctcttt ttgttgcatt attccagtta ccaataccct taagcccaag 152760 ttcatttatt ttagggtcat caactttgag gcggtatatt ttccctgatt catccttaaa 152820 atttgttaca cctttttcgc cttcaaatct atttccgaaa ttgtttccaa cccattcatc 152880 tttattaaat gttcctttaa caagcaattt gcattttccg gttttaacat ttctcataga 152940 tactttatca gacataaatg ctttagacca tttactaact gcttttctat gggcctttct 153000 tgcgaattca taagaacgag aatttttatt agagttcaac attctaccta aagcgaaagc 153060 catttctttg tttctatgta ttttatacaa taacaaatga gcaaagaaat gttctctaca 153120 tgtaagcttt actaaattag atttgtcgtt tgacccaccc atagacctag gtacaatgtg 153180 atgaatttcg ccttcttcgg caggattctc ctgccgtttt ttaattaaat tattatatat 153240 tttagagtaa ttcactaact ttaacccaag ttccttttat tagaatttcg tcattttcat 153300 taactataac ttcttcacca tctataatag ttttaaacca ttgtccatct ttagcgtatt 153360 caaatgggga ttcacctagt gttaatcctg taatagccat tatatcaaaa gcttctttac 153420 tcttcattat atcaacatct ttcatacccc atgtatttaa gaatttacct cttaaaggat 153480 atccaccttg agtatcttga atacgagaag tcaataattc atttaaagcc gaatctcctt 153540 ctgttaaaaa caatgttgtt cctttacctg gttttccata aaagtttgct ttaatatgtt 153600 ttgcgacttt ggcttttgct gcttttttag ctgctttagt ggctgcagcc tgttctgccg 153660 ctaatttacg ggccaaaaca gcttcaataa taggcatcaa gatggtttca gtcttcatta 153720 attgatttgc aagtttttta acatcaatat ccatgtggtt cttgacttca ccccaggtgt 153780 ttgtcagacg ttcttttgtt tgaccgtcaa atttcatatt actcatatta cggataaaca 153840 ctaggaccgt cagacattct ttaatacggg ctttagtaac ttcaatacga tatttacgtt 153900 taatactagg aataagttcg tttgaaattt catccattaa ccagtcaata tgagaaccac 153960 ctacttttgt atggatctga ttaacaaaag ataagtgtcg gaatccatct ggtgaattag 154020 caaaagctac agaaacatta tcattttcca tagtaattac tttttcacca aattgtgaag 154080 caaatttttt gaagttacct tggatttttt taccattaaa tttaaaagta attttgtcaa 154140 aaataataga taaagtcatt aaacgatctt ggataatatc ttggatagtt ttatcaatac 154200 ctgtgcaatc aaaacgatca aaatctggaa caaatgaaac actggttcct tttaatttac 154260 ctttcttaac agaaaaatta atattttctg cattatcatt acatgtaact gtgatgatat 154320 ttttaccatc acctgtaacg ccttcaaacc aagtactaaa aaagtttgtt aatgaagacc 154380 cgacaccgtt ttgaccgcct gtaacacgtt ccaaatcatt accaaagtta ccacctgcct 154440 ttgttcttgt ccatgcagca acaggcccgg gaatagattc tccttcaggc gtgattacat 154500 tagcttgtgg aataccacgc ccattatctt ttacagtgat tttggaatct ttaatttcta 154560 cttcaatttc atttgcgaat tcaaacttag tacgaatagc ttcatcaatt gaattgtcaa 154620 ttatttcgtc aataattttt acaagacctg ggacataagt gagtgtttta tattcaccaa 154680 aaagaaatct ttcgtgtggt tcgttagaaa cagacccaat atacattgct ggtcttttaa 154740 gacaatgttc tctatcagtg agcattttaa tattattatc tatcatttac tgtcctctca 154800 aattgacgta ctatattttt ataagaacct ttaggaaatc ctctgttaat actttctttt 154860 gaaaatacac taactttagg tttgtttaat tctatccata atttaaataa agcagattca 154920 tatttccata caggacttgt tctatttttt aatccacatt taattaaagc ttcttttgta 154980 tgctttttat tataaaatgg atttttagaa cctttcattg cgatagaatg tttttctctc 155040 ttaagcccat aacacggatt tttatcacct aatttacatt cggacataag ttttaaagat 155100 gatttagtgt gttttttatt ataaaacgga ttgtcttctt tgagcacagg catcccaaaa 155160 aatccattag gagaagccat cgacatatta aaaaatttag tagattttac aacattgttt 155220 aatttttggt atttatactc agcctgaata gcttcttttc ttgtttcaaa cacatctaca 155280 atacacacat caaataaatg tggattattt attttttctt cataataaat ctttttatat 155340 tttttagatc tgacagaacc tgtataacct tcattaaatt tctttaatga agtagatcct 155400 atataaaatg gtgggagctt atctccagaa taaattgtaa gataaactat aaacataaat 155460 tctccgtggt ttccttagtt aaaagggacc gaagtcccta tattattcaa aaaatacatc 155520 tagcaattta cgtattgctt ctgcctgttc ttttgtagta acttccaaat ttagtttaac 155580 tgaattaggc tttaaattaa atacctcacc agttggtggt tccataggca ttacagcaag 155640 tggaacatct ggcatagtaa ctgggagata atctatttct ttacaatatt tttctaagtc 155700 atcatcggaa aaaatatata aaggtgtgtc acttgtatca aattctaacc cgttaaagaa 155760 tctgattgtt tcaaagcatg agtaattgtc ttttgaatag aaaaaaggtg ttcccaccaa 155820 tttattttcg gtaacaaatt tttcaaattc tttagcccat acagttccgt tatcaagaat 155880 aaacgcatca aaggccgatt gtgatttaaa aacataacgt tccatatagt caaacatatt 155940 actgtccttt aaggtgttct agtaattcat taataaagat aacaagttct gttttagaat 156000 ttaaagtttt tgcaggaatg tctaatttaa attcttcttt ttgatttgag tttttatctt 156060 ttgagacaat tacaaagaat tctctaaatt gtttatcttc tgttttaaat gttaatgcac 156120 tactgtgaat agggatagtg taagacggat aatataaatc agaaaattct aatccattat 156180 caaaaacaca tcttaaaaat gtattttctg tacgattaaa ataaactgaa aatggcatat 156240 cttgtaagtt gttgtatata acaaaatctg caaaactaga ttgggcatta caaaaactac 156300 cgtatcttga tacgttaaca ccctttttaa attttaggcg tccaataagt tcttctttca 156360 taattatgat tccaagtatt ctaataattc attgatcact gcttttgctt cagctttatt 156420 agtaatcgtt ttattaatta ctaactcttt agaatttaag acttgctccg gtttctcaat 156480 atcttttaca gcttcaataa atttaaaatt agaatgcctt agttcacatt tagaaccttc 156540 aatattaagt ccaaatgtat agaagtctaa cccagcatct gaaaatacca taccattatc 156600 aaatacaatt tctaaatcat accaagccgg gttggtttca attaaatcaa tggtaaaact 156660 atggtgtttt aataaatact tatctaaaaa gtcagaaaat aatacacgtg ttgtattaaa 156720 ttcttgttgt tctacatagt gtttgatact aattggagat ttaaatttaa atctccctaa 156780 tgatttaata aatttgctca tagcacggcc ttagcccatt tagtggtttt agatttaatt 156840 tgttcattta aatcatcaat aacaatacac attaggtctt tatcattgac aagttcaaat 156900 tcttgtttat tacgatagtt aagccataat gtatcaatta agcaattaat aacatcagcg 156960 gcttcgccag ttgcacattc gtcaacttca tcttgtcgaa atgtagcttt agagtattca 157020 ccaatttctt cgactaaatg ggcaaaaact atacttaaat cacgttctgg tgctttaata 157080 cacattttaa cggtcgggct gatatctaaa attggttcac aatcaaaatc aggttctttt 157140 aatggttctt tgaagacaat cggtgtttgt tcatattgaa taatctgaat acctgataat 157200 tcaaaaaact cttgttctct ggaatcataa gtgtaaccac cgagtttaga taaacaaaca 157260 aatgagccaa atgattcatt taaattagta tatataattc cgttaatata tacagctaaa 157320 ggattgccat aatcatctgt ttttaaaatc gtgacaattt tagatttagt attatgtaaa 157380 aatttaaaaa taggataaag acgtctttgt tcttctgttt cgggccagaa tttatttaat 157440 ttataagaac ggccttcttt gaacataggt tgacgagtaa atgattcatc tagagtttgt 157500 tcacctaaaa cacaccagaa tgagtcatca tttgataatt caacaatttg attattgact 157560 aaaattttag atgcaccata atattgcatt gcgttggaaa ccgtcacatc taaaatttgg 157620 acttccatgt tatcaaaaag acgaattcca cggtcttcca tgattctata aaatgcactg 157680 acttggttta aagaagccag gtttaatgta tagatagaac ctttactaat cataatatta 157740 tccttttaaa ttttcaaaga aaaaatcagt tttaacagta ctaccacaag aactgataac 157800 acgtttataa acagcaacgg cttcattatt ttcaataaca tataaattcg tcagatgaat 157860 catatgagac acttctgaat ctttttgaac aacagttaaa gtgtttgaaa ataaaacatc 157920 ttcaaattca tcacgtgtaa ttacttgttc cattataaac tcccgttatt tgttttgttt 157980 gtttcgtttt gttgtaaata taatacaaaa taaaagaggt cttgtaaacc tcttttttca 158040 ctttttaaaa ctattttttg atagatacta ggtctatgtc tttttcttca ggaacttctt 158100 caagtccaag cgcatatcgt tctgctgttt taagcataat aatgtcttta gcacagtcat 158160 gaatagagtc gtgtaaaaca aacccattta aaacaccttt acgaatagga catatagtca 158220 tgtctctgtc taataaaagt tttctaatag aagtccttgt atcattttga ttccaaaaag 158280 cgataaattc tttcttaaac gtatctacgt cttctaaagc tattccagat tctaattcac 158340 gttgggtgat catatgtttt aaaataggaa agtcgaacga cataccacga ctatatcctt 158400 gagatttcca gaaatcaatt ccttgggcat ctaaataatt ctttaatata tctagacctt 158460 cattaatcgt aacgtcctgt ggtgttctaa caagattctt tttagcttca ggttcttgtt 158520 gtttccacca ttctactgtg gatttataga atactctttt acctttttgt gaattcaaat 158580 caaacttaat acgcaaccca cgtttaacaa gatcttcaaa agattctact acattagggt 158640 ccgggttaaa agtaataata gataaatcta taacagccga atccggttgg ttaccaaaag 158700 tttctaagtc aaatacaaaa tcaatcatat ataccacaca tttttctgag cccgtgttgt 158760 tccaacatac aatagttgtg aagcaacatc tacttctgca tattttataa tacaaggagt 158820 ataaagaaaa ctatttttta cggttacacc ttgtgcctta tggattgtac tacatggaat 158880 gggttttact tttgtgaaag catctttaat ttcccagaag tcatcccaat aagcgcgtcc 158940 attgcctgat ttatattgtt gtgcaacttt acctaaaaac atccaaagct gggtttggtt 159000 ttcttctcca taaacaacat taagataatt ggttgtgcct tcatcaacag attggacttt 159060 taaaagaaag taaggtaaat cgattttaaa atcaacccca cgacactgaa gttttctaga 159120 catttccttt acgtctagaa tttgcacaac ttcaccatta ttaaagatga tttctttcat 159180 ctttttgcct tcaaatttta tagtttgcat atatggttct tgcataacta aagcttcacc 159240 aataataaat ggatcatctt ttttataaaa gtttttacgg atgatttgat ttaacttatc 159300 aacagattta ttagtataag caaaaaatct attatcaaag aaatcttctt cagattttat 159360 ttgcttaaaa taatctatca tcatatcacg taaagaaggt ggatgaaaaa taccttcgcc 159420 atcaataatg ttttctctaa tccatccacc ttctctaatt tctgtagcaa cttcaataat 159480 tggttgattt gaacgcttta cttcagtcag atgcatttgt ttaaaccgat gatctgtaaa 159540 aaatctagat acacccaggt catcttgagg ttttaactgg gctttatctc cgatagcaat 159600 aacaatagtc catggcatga tgttgttcat taaaagctca aataattttg tatcatagaa 159660 cgaagcttct tcacagatta atacacgaat tttatctaac tcaggggcct ttctttgttc 159720 aaaaatccga tgttcttcat aagttacagg atttattttt aaaatactgt ggattgttga 159780 tacttctcgc ccagtaaaat cagccagtac ttttttagaa gcatgggttg gcgcagctaa 159840 aacaactcca gggatccctt ctttttcgat gaaatccata ataaacttca ttaataaact 159900 tttacctgta ccagcaggtc cgttaattgt taaatgagtt gttttggctt tccagttgga 159960 ttcttgttta tatgcttgtt gaatcaaatc tgttgcacat tcgtaggctt ctttctgacc 160020 ttgagttagg tcatcaaatt caatcatact attttcacct ttttaatata aagtgtatct 160080 aacattcgct tttggagtgt cgtcaaatat tctggtttat ggattaaaat tttttcctct 160140 cgtttaaacc agagaaatct tttatattgt attttgtatt taggtttaag ctcattaata 160200 atatattctt taaaacgatt aaaggcctca ttgcagagac cttttgtttt atatatcatt 160260 aaagcttgtg tgtcaggatt ctggcataat atatcaaatc ctgctacgtc tttgtagact 160320 atcgcataat aatacataaa gttcttttcc tactctttta taagaagaat ctaatgaaat 160380 acctaaatat aattttaact tatcatactt agatagctta ttaaatcgtt cttcggcttt 160440 ataaagaaca tttaaaattc taagacttct atctttcttt tgtatgcatc tttcatgttg 160500 ttcttctaaa tttttaagag acttttcttg ttgattaacc cggtttctta gttttttatt 160560 atttgagttc atactaagtc tttttttatt gataataagt ttagacctaa actttgttat 160620 ggatgaaatc gcttcatttt tctctttatt tacactatta attttctttt taatatcttc 160680 tagtgtcata gaacttttat aacaattata ttctccttta acaggaatca cattaccttt 160740 aacataccct ttagaattat caaatctttc aaaagatata ccttcaaggt cattacaatg 160800 tttaggcata gacatcgatt cgccagaata tgcacacgtt gtttgttcgc aaatgttttt 160860 aacatatctc aaagacaaat taaattcttt atttcttgat ttggcggatt tatggatttg 160920 ggtgtatttt ttaatcacat cttcaatttg catgatgacc tcctagaata attgagagac 160980 aatatacaac attctaggag gtttgtaaac tagttaatgt aaactatttt tccgttaata 161040 gaataagtaa tagacacttc ttttttatgt tgttttttaa tattttccgg atagatagga 161100 agaatagaat caacaattct caattggtct tctgtactca tagaagggct aacaggatag 161160 cccattttat tgagaatttt agacatttga aataacgtta acattaatat cctcgttctt 161220 ggcgagcaaa gttttctgca ttttttaagt aatatagaac aaaaatttct tcagaagaca 161280 tgccaagacc gataagttta ttcataaaga aatgaacctg gtcaataagt tcaaatttga 161340 cttctaattg atcggcttca gataattcag aaaatggttt attcgacatt tcttcatggc 161400 gagctttcca aggtttccat actgctgatg cttctttatc gccattagac atcccgccta 161460 aagaagtata caactcacgg gtttcgtcgt ttaaatagtc atcttgacta cgcatccatt 161520 taagaatatc accacatgtt tttaattcat caggcgattg gttattaaat ggtttggttt 161580 ttgctaagaa aacttgtaaa gatttttgca tatctaacat tacttgtaaa gggtcttgtc 161640 ctgaactaat aatatcagaa tatgcttcac gagcttttgt taaagaacct tcatccacta 161700 aagttgaaca tacattaaaa tgagccattg ttattcctta ttcaaaatat tttaaagttt 161760 tttctgggta attaacacaa acaccagtac ataatacatc attacttaat gacgcatcta 161820 aagaccattt tttattttca ggttcccacg taggtttttt gatagaagat tgcacagaac 161880 cattatatga agtaaaaaca tattggtgtg attgtttaat aaaaagggct ttaccaaaat 161940 actggacttg tttatacttt acttctccac aattatccca attaataaat ggctttgaca 162000 actcatctaa tttttcattt gcttcttcta atgtagaaaa acaattttca catggagttg 162060 ttccaacata ataccaaatt cttggttctg aactggggct ttcgacaaaa attaaatcca 162120 tcagtctgta attattagtc tcgccattat cccactgcac atcaatacca aaatcatcta 162180 cgtctaaaga atctttgtcg atattagata tagttccttt gcacggggga tttctacttc 162240 cggcatgtgt actataaaac tcagaaccag ggtgtatttt tactctattt ccaactacag 162300 catgtttaat atccattata ctttccttaa atttaaggac ctgattaatc ggtccttcat 162360 ataattatta aaaagactta tttatgattt cagacatttt agataaagct tcatactcag 162420 tagcaaattc ataagatatc ttatgaaatt tgacaacata cactagttct gggccgggtt 162480 ctactaaatc tttttcacta tctactaaat ctttttcact ataagtattc tttaaaccat 162540 tatcccattg tacttttatt gataatccga aagcagattg gacatgaata tcttctatag 162600 tcccgacaat tttaggatta gccttaccta aattatagta ttctgacgtc tttttaattt 162660 ttacgcgatc accgacttta aaaaccatat tattcctcta aaattctcaa tgctaattga 162720 acatcataaa aagataatcc aattagcccg ttaacttgga caaaattgcc acctaaacca 162780 tatacataat gctcgataga atcatctaat acaacatatt tttcgacttc atggtctaaa 162840 acatatctta atatactttc accacgggat cgtccacagc cagtaaaatc tattgtatca 162900 tggatgtcta cgcctaaaac ttcagaaatt tctttttctc tatctttata atcatcatgc 162960 tttgatgatt tggcccatga agaaattaag acaaccttag catcagtaga tgctagtaat 163020 tctttaaatc gatttaattc tttgatgcca atatatccta atttagatct aatagctaaa 163080 tcatcattaa aacaagatac ttggctgttt aatacaccat caatatcaag aaatatcact 163140 tttaattttg actgaactgg gtcttttgaa gaatgcatga gttttatcat ccttagcttg 163200 ttcaaatgtt gctttaaatt caatttcacc acggtaatct aatggcacac atttaggtag 163260 tgatccgtat actgttgatt tattttcaag ctcaacggtc attttagaaa ctatcccata 163320 aaaatcttca tatgttttaa ctcttaaaac tgttcctttt attacttgtt taccatcagg 163380 ggcttcacct ttgtcttttt tgtggtcatt atatatgtca tcaaacactt tgtttgaata 163440 ttcctgaata gctacaagaa attttctat 163469 SEQUENCE LISTING <110> Optipharm.CO., LTD <120> Novel Proteus mirabilis specific bacteriophage PM2 and antibacterial composition comprising the same <130> 1_21 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 163469 <212> DNA <213> bacteriophage PM2 <400> 1 gggttttaac ttcagccata caaacaggaa catctccaat attccacttt ttataaggaa 60 gaccaacttc aatccatggt gtttttgcta aaacattata catgtctata gtgagtctaa 120 gcttccagaa cctatttcta gtaatagata taggtttttc tatatcatcc cattcaccta 180 taaccggtaa atattgccca ccaccatact cttctatttc cattgtatac ggattttccc 240 ataaaaaccc atcaaatgga gcatgtagtc taccatcaac cccttcagtt ggttcaacag 300 tttttattcc taaagaatcg gacaaaagtc tattagataa ccagcctgaa ttgagttcat 360 tggccttatc aattatacac tgacggtgtt ctttatatga tttggtatga gattctaata 420 aaccatcaat aaattcttta aacatatatc ctcctgtttt aatcactggt ctaatatact 480 acattgtag acctgtgtaa actgttttat tctgcccatg gatcggactc agtagtatca 540 tcacggacaa catcttcttc aatcaacgtt ccatggcatc catatttttc tgcatcttct 600 aaagcttctt cgagagtttc tgcttcaact tcgtagactc ttcggccacg aacgtatcca 660 gaaaaattaa taccaatttt aaatgttgcc attttcttct ccgatcttaa tcaaaatttt 720 ggccaaggct tcaacatatg tttttgaagc caaaataaaa ataccattgg tcccttctgt 780 tttagagctc cagaactgtt cccactttac aatagatatt ttatgctttt cgataatatc 840 aaaaatattt ttaggtggtg tagtaaagaa atcaaataca taccaattat atccatcacc 900 ccattcaata ccaccagatg gggtgaaatt acctaagtct tcccagttgt gaaaataaga 960 aagcagttta cgattcattt cttgtttagt cataattagc ctttacaata ttttgcatgt 1020 ctaagtttag cttctaatcc agaacaaata ttgtctttca tatattgttc tatttcttca 1080 gccgtagcac cttcattcac aatcatatca ttaacatcct tggatgtaaa ctttaatttg 1140 tcccacataa caactttttc gccggcatca atcaattttt ctaaacgttt agatgtatct 1200 gggtgcctag gttcattatc taatacccat actctagtat gtggaaatgg aacaaaatca 1260 agacttaaag taccgcctgt tattgcacag gaattaggaa taaacaaaga atctaacggc 1320 ccttcaaaca taaaaacagt tttatttggg tcaactgtat cttgtccgta tatcttagta 1380 gaactctcag aagcttttat tgtcacatat tttgcattag atttctttaa agcccttcct 1440 tggaaacttt ctatctcacc atctttattg aaaataggaa taactaatct atattcttgt 1500 tttggtgtct catatgtgcc aggaacaaca ctgttacata atccttgcca atctgtagta 1560 aaccataacc ttgaccattt gtctttagga atcttcctgg ccttcacgta agatatgata 1620 ggatgtgatt ccggcaattt atccaatcgt tcagaaaaat ttaatttttc tattatcttt 1680 ttaggagcat gtttgggttc gaatttttct accggtttat aaaaaacatt ttgttctttt 1740 ctgcgctcca ttaataaaga aggccaaagt tcaggatgat gggttttaac aaattctgta 1800 aatgggcgac tataatcaca gttaaaacat ttgacccata aacaatccat ttcttggagt 1860 tctataatcc aaaatcttgc tttagtatca gaaacagcag aatcaccaca aataggacac 1920 ctacagttaa ccctaaatgg tgaattgctt gtttttttat acattggttc gaatctgact 1980 atattgtcag caaaatcata atcagctaaa aacatataac ctctatacca aaaaaggagc 2040 catggcccct ttatatcata gtttaattag tagcatcttt tttctttttc tttcctaatt 2100 tattagggcc ttttgaagta atagaaccag aggtttttcc tgatgcaatg ttttctgtac 2160 ttccaccaga atcaccagct atcatttctt caataattgg atgttctaaa aatgattcgt 2220 ctaaattata gtcatccatt atctcataga cttttttaac ccgttcagca taaatttctg 2280 aaccttgctt taaccacctt acatctttat gtaaccgtgt ataagaaggg tcgttcataa 2340 cgaattttat tacatcgcct ttttcattaa taataccttt tttaaaggca tcccattcat 2400 taaaaggtgt ttctaacaat ttaattatac tcatagaata agtccttcta agttaccagc 2460 taatttatca atcttatcac gagtatttaa ttctgcttgg ttaatcattt taccttggac 2520 aacatttaaa tcgggttctt ctttaatagt tgcatctgtt tctacccaac gttgattacc 2580 ctttttaaca attaaattaa atttattcca tttattttta tcgccataac gggacttaat 2640 ttgtttaatt aattgttgtc ccatttgagc cagctcttcg gtttctacaa cacccaacat 2700 aaaatccgct gtagcgggta aacctgctga ttctgcaaca tctgccattt ccatgtctga 2760 agcagaccat gcttgtcttc cggtttgagc agctgtccat aatacggttt gggtttcaat 2820 agcaagtcca cgtaattctt cagcaattgc ttttattaac gtataactgt tttctgtaaa 2880 ttttagacgt gtactgccac aaatacctaa gtagtcaata ataataatat ctggaataaa 2940 cccatctttt aatttaagtt catttaaaag agcccggaaa gtattggcat tggcaccacc 3000 tgtaggatat tgcttaaact tcaatcttcc tggggttttt ccaccggaac cttttttaag 3060 gcgttccatt ttggccttaa attccgtata agtaatatta ttattatcaa tgtcatctaa 3120 agatacatcc aataaattgg catcaatacg tttagcacac acatgttcgg ccatttccat 3180 actgatatat aaaacgttat atccagtttg aagataatca gctgctaatg aacatagacc 3240 aagtgattta ccaacgttaa cacctgccat taaaatgtta agtgtacctt tttcagcacc 3300 gccttttgtt attctattaa gaatagataa tttaaaaggg accttattag cttttgtctg 3360 atataataac catcgttttt cataatcgtc aaaataatca tgtccaatat cagaatcaaa 3420 acatatggac aacgcttctt gaagaatctc tgggataatt cctttgtcag gaagtttttt 3480 atcacgtttt gactcgtcta aagaggcatt tgtttgtatt tctatacttt tagacatagc 3540 attatacaaa gcaatgtctt gtacatattt ttctgttgat ttaataagcc aatcaaaatc 3600 ttcaggtgta tttttcattt tccctaaaaa ttcttttgcg gctttaaatt gagaatctcc 3660 gagtgaacta ttttccaaag caatatctaa agctgttaca gttggaacgg atttaaattc 3720 ttctacatgt tttttgattg tattaaaaat agttttagaa gagccatcaa aatattcttg 3780 ttttaaatat ggccaaactt taacaaaata atctttatta taaattagct gagataagat 3840 tacgttaacc atcagtgtcc cttaaatata tcaaaaatac ttttggattt aactttagta 3900 ttttcaattt gtgatttaat acatttttca atatgtggtt ctaaaatatc ttttggcaat 3960 tcagaaagag tagaataatc atattctact tttccgtttt taatatccat agaatgaata 4020 tacactaaat gaggagtgtt gtcaattaaa atcattattt cttgaataat atctttcatc 4080 gattctttga caatgtttaa tgacttttca tatatttcct ggtcattccc tatattgtca 4140 agaatcttaa attcttcatc aaagttttgc ataaatataa tttccacagt cccaaattcg 4200 acgaagcccg ttattataac agttttcaac ttctgttaat ttaggattaa aatctaaaag 4260 tttatctttc aatttatgtt tcataaacga agacctatga taaagcttac cttttacaat 4320 ataatagtag cacggttctg atgtaccgat gtattttaat cctaatttat tatatacatt 4380 tccttgtgac catcttctat ttgcataaga aatatatgtt aaccctttta ataatttaga 4440 agcacctcca acaactgtat atccagcttt agaacataat ctaagtaatt ctagatcata 4500 ttctttatta tatctggatt taccaagaac agctacttgg acaagttcat cattatagaa 4560 taacccttta taaattgaac ctggacattt accttgtagg tggttttctt ctatgaaatt 4620 attagcaatc tttttatcaa ttttttttaa tgaacatttt ctagcgtata ttcttttaga 4680 taacccaagt ttatttttaa taacggattt ccatatttct tttttaacag ggtcattcca 4740 ttcattctca aatatatgaa gaagatttat ccctttagat tcacaaagtt ccgttttatt 4800 gagatggtat ctatacaatc ttttatcatc ttctttagaa ttagaagagt gccaatatac 4860 cccattaaat tcgatagcca aggagtgact aggaacatag atatctaatt catatggtaa 4920 tataatctgt ttggtgtttt gttcacagga cacacctagc gaacaaatat aatcatatac 4980 ttcttgttct aatccagatt taccagacat tgatttaata ggatatccat gtttttccat 5040 gaacttaaat gcagaagaat gagagtttaa agataaccca aaatgctttg caacgtcttc 5100 ccaagtttta tttgatagat cttccattat atctggattt tttatgtcat ccaaattctt 5160 ataattatat tgtaatggat gttcaccaag ttgatatttt tttcctcccc attttctttc 5220 cgttccgtat ttgtccatac aagttcttct agttttattt tgggttttta cagatttaat 5280 agagcactta ttagaacaaa cttctaataa tttatttctg tatacaataa cgggtttgcc 5340 acaatgacat ttaggcacat cttctatttt agtaataccg ttttcaagaa acacaataac 5400 ctggggcaat gaagccccag gaaatgattt aattatttct tgaaataaaa cagtattatg 5460 tttttctaac cattgtaaat ttcgtttcgg gactaattta ccattagaat aacataaagt 5520 ttttatttca tttatcataa ttcttccata gattccaatt catccatagt agaagcaaca 5580 gaactatcag agaaaacatg atcttctact tcaagattca ttaactcttt tacttcttgt 5640 tctactgatt catcattaac catttgccca agtttatatc ggttttcaat agcttcacgg 5700 aatggagcat gtttcaataa aggtccccag aaagcaacac atcttgtgtc tttagctcgc 5760 caattctttt cttcaggaac catttcaccg gtttctttat ttaaaaatgc ttgagtatac 5820 cagccgtttt taggtttaac aacaaatcct aattctaaac ccatatcaag taagccagaa 5880 taagggtcaa taccaccatc aaatgtaacg tcaataaaga atttagattt ttcttttact 5940 gtacgagatt tttctacatt taaaacaaat tgataacctt gaagatcggt accatcttta 6000 atttgacgac gaccaataat atacacgtta tctgcagaat acatcacccc ggtattatgt 6060 gtaactacgc cattttctaa tacataatgt tctacatctt ttacggataa atcgtatact 6120 tcttttttac ctacgtgatt aatattttta attttcatac atcgccttgt tcttgataat 6180 agcttgtttc aatataataa tactggtttt ggttacgcat aatctcattc gcaactcgtt 6240 cgccgtattc ttcgaccatt tgtacataat ctaaacgtct tagatagaac tcatttaaga 6300 acgctttaat tatgtgaatt tgtgttttat ttgtcatttt gcaccttaac tttacagtta 6360 tcaaaatgcc aacgtctcat attaccagga accccggatt ttccacaatg tggacatgat 6420 atagtttcta tcatacctaa tttagcttta agtgttagag gattcatata tcctaaagct 6480 ttatattcat cgaccttaga tttgtcaaca aacacagttg gataccgctc tttgtcttca 6540 tgtactaacg taaccagacc ctttttaaac tttgatgtct tggcaagctt ggctttatgc 6600 tcttcagttt tcttaacacc ctttctggat ttagacattt tgagtttagt ctcaatcgac 6660 gctttcttac cagtattagc gccaatataa gtcccatcta aaactttagg atgattggta 6720 ggtagcctaa ctcgttttcc tgtaatagtg tgcatgtaag tcccactgtt tgcatcgcta 6780 aagctagata gtctcgcgag actcaaatta aaatattctg ggctggcaac aacatcatgt 6840 gcaatgtgat actcacgttc tttaacaaga atatccgggc cttcgtataa aatatgacat 6900 tcgatgtctt cacttttaac aagagatcta taacctggcc atctagagct accaaaatat 6960 tgtttacctg ttcgagtgtc aaagatttta taatcatcta ctctggcatt agatttgctc 7020 ccaatataat aaaacggtgg ttcgtttcgt tcaattctag atttaaaaat aattttatat 7080 acaatgtcca tactaggctc cgattcaata actaatagta tttatatcgg agcttagtcg 7140 ttatgtactc agccgatact tatcgaatcg cacaatccat accaactaat aaatctttgg 7200 cttcaaccca cgttggaata tcttttacca ttaccaagaa tttatgtgta tctgaaacag 7260 ttactttata tccatcttca aactcgattt ctatacattc aggggttcct tcagccaaag 7320 tttcggggtc ccaaatataa gtaacttcat tatcaccaac taaagtttta actctatcac 7380 ctggtttaat atcttctaca tttttagtag aaccatcagc cattttaatc ttagttccag 7440 caacaacaca accaccagtc ataacggttt tactgaacat ttcaattgtc tcaatggtat 7500 gattaatacc tacacacgga atatccttta aagtaaaata tggagtagcc atacggaaca 7560 atgattttaa ctgcttagcc cgtgtcatat cagcgacaga tttttcattt aaagcatctt 7620 caacttcttt cttagaagct aagttaccaa tagagtcaat aaagactata actttttcac 7680 ctcgttcgat ggcttctaat tgattaatca tatcaatttt aagttcttct acgtttttaa 7740 ctggagtatg aacaactctg tctgggtcaa cacccataga acgtaaatat gcacttgtga 7800 taccaaattc tgaatcgtaa aataaacaaa ttgcatcagg atatgcattc atatatgcgg 7860 ctactaatgt aagtcccata ttagatttaa agtgtttact tggaccagct aaaatagtaa 7920 taccagattg aaggccacca ttaataatac cagataatgc aatattcaaa gtaggaatct 7980 tagttctaac aacagatttc tcattgaaga atttagattc gctaagaaca gaagtcattt 8040 tattagtaga agctttcatt aaacgttttt ttaagtctga cattttttat cctttaaaaa 8100 tgacaaacat aatattttac tcaaatcact aattagattt cccaaatagg gcctttaaca 8160 ataatatctt catatgacgg taatgcataa atacattgta cattacattt aaaatatata 8220 aattccgcta aacccggatg aaacaccttt tcaggatttt cttcatatat aatattaggt 8280 ttagccttta atgcgtggta atattctgat ttatttaatt ttaataattc gcagtcagga 8340 tatttttctt tatcccaaga atcattaggg tctgttataa ctaatttgag atcatacatt 8400 ttacatgtat gatatacata atcgaaatca tagcacttgt ctgatattct aaatggaaaa 8460 aatattgtat tcttccaatc aaagtctata caggattgtt gcataaactt ctcaggaaca 8520 ccaggagtaa ttacttcttg tgtaacaatg attttatcag acaaagctcc atgagacact 8580 agaacatctt tctggcactt attaagaact gttgtgtaaa tacttctatt tacagaatca 8640 acatcttctt gaataaattc atcaatatat tctcttgggt gtttagggtc ttttgtgata 8700 ttaaaattaa aaaagaccgg aaacgctcct ttatatcctg ttatatcgct tactacggca 8760 tcacaattat aaaaattagc taaagaatct accataaatg tattgtattc ccagaatgtt 8820 tttctggatt tataagcatt ttcttgataa acagcttctt caaaaataat atcaggaaaa 8880 tattcttgta attcctctga atcttcacat tgtaaagaat gtggaataac aataacatca 8940 cctttttggt gccgatttaa atgtaattga agatttccgt cttttaacag ggaatatttc 9000 cctgttttat aagacctcat agaatacatt ggtacaatga gattcataat aatccttata 9060 gaaaagattc tacatatttt atatcgcgtt caaatacatg agcagaaacc atagaatggg 9120 tgtaatgacc taaagaaaca ccacattctt ttgcaatgta ttccattaat ttaccttgta 9180 aataaatatc aagttgtaat actactgcac aattctgtga acgcatatgg gtgtgagtat 9240 ataatttacc attacgaata taatatgtta tagaatctgt acaagggtat tctaatgatt 9300 catctgaatc taataaagcc tggtcttgtt cttgaagaat ttggaatacc actcttcgtg 9360 agttaggttt ttctttaagt tctttaagca aggcaggtaa ttgggccaaa attctaggac 9420 cataaaaagt gttgaagtta gcaggtaaaa catcactttt tggcttacta ataaatttag 9480 ctacatttgg atattcttta aatgcttctt ctgcatcagt tccaccagaa atcataaatt 9540 gccaaaaatc ttcagcgtat ttgtaatcaa tacggtttat taaaaggtct tcaaatttat 9600 atgtagaagg gtccattact cgaaaacaaa gtgagccaat ttctcggcat tcgccaattc 9660 tggactcagt aataaagtca tattcagaaa taactaaatc attaacagtc ttaaaagcgt 9720 cttcaaatgt ttgtttaaca atcataaaag tccttgtaat tttttagaat attgcattaa 9780 aaatataatt aatggctgtg cttctggagg agtatttaat aatttctttt cttctacttg 9840 tccattatat atcggtaaat gattagcttt tttggtttgt ccaattttaa ttgctaattt 9900 attccgttta ttaaaaagat caatcatttg tttatctatt tcttcgatag attttctatc 9960 tttttctaaa gattctttat tattcagatc tttaatccag tctttagcca ttgaagaaga 10020 aatattttta attaattctt taggaattgg cggaatatca attccaggat aatccttatt 10080 taagaatatt tttggtgttc ttggtggcca aaatgattca catttcatga ggaacctcaa 10140 tttttataag aataaagtaa taatattatc attaaattta attagcatta tttacctaat 10200 attttaccgg aagggccatc atacaaagag gcttttataa taaaaccttt tagatcgtgg 10260 ttgtattttt tgaatttaga ggttttatct gtaaatgccc tggttgaaat atttctactt 10320 aaagcaggca caagcctgct caataaagtt ttcttcatat atatctccag ttgtaaccgt 10380 atgccttaga accagatttt atggctctag taatattaga agaccttggt ttatttaaat 10440 acattgcagc cctaaattta gaagaaaata ttatgctttc tgaatcattc caagctacaa 10500 caggtctatt atcaaaatga ttgtggtttt ccgccttctt tttatcagac atctttttaa 10560 ttgtttcttt agaatgtttt tttccttcaa atccggcgac atttgataat tttctatttt 10620 tactcattaa taatttagac ttttctgtat gctttttacc tttccaaggt gatttaagaa 10680 ttaatgtttt tcgtatctta gatttagttt cttcagaaat aggaacccct ttaagaggac 10740 tcctattttt agaaaaatat ttttttaaag acctacttat tttaatcttt gtatcatctg 10800 atattgccgc cccatatcca cctaatttta gattgtatga agatctatct aacacaacgt 10860 catttgtcac taattcagat tcttttaaat acgagtcttc ttctgtgtca caaaagaaca 10920 aaatttctct ataaaaatta tctttaccat atttagctat tgcggctgat aaggcttgtc 10980 cagaaccaag atatccatca tttaaatttg atgtactatg tttcccaata taatacatcc 11040 catttaattt gcatgtcgtt ttatatacta tattaaatct ctgggtatct ttcttcatca 11100 tcggcaccgt ctaaaacctt gatttctatt tcatcaggtt tacgatcatt tttagataat 11160 tgacgtttat aataccgttc acaatattta catgtcgtac cacagatttc attagcacaa 11220 tcaaaatcag gatgtttaaa ccaacgttta tttaaaaatc catctaataa agaagtttct 11280 aaatatactt ggtgttgatg gtctaattct gattgaccat tataaattgt ttctaatggt 11340 ttccagagct ctaataaatt accttcaaac ttttcagatg cataagcttc tagaacttta 11400 acaatatatt ctgttgttcc agtacggcct gatactttaa actgagaaat accaatagaa 11460 cggtatagct caagatcttg tggacgaata aatcttgtac gaagccaatt aaatgggtca 11520 gtatcacgag ctttaataca gtgttgcatt ggatatccat tcaaagattt agcatcttct 11580 gctgttatat ctgtactatg aaaaatataa catgaatcac ggtaagagca atgagttgta 11640 tatcctttac cggcatttga acagaattcg tttacaagca attcaaatat gattccattc 11700 ttattgcaaa actccgcggc tcgttttaaa aatgaaacac ttcggttttt atgaatacca 11760 caacaaactt tcttaatatt atattggtca tgaagatatt tgatttgtgt tacagcatca 11820 acatgaagaa tagtagaaac ttcaaattga atttctttat taacttcacg aataatttcc 11880 ataataattg gattagcaac cgttacacga taaacaccta tactccatag atattgaaca 11940 taatcttgga tggctttctt tttccattcc tgtaactctc ttttagagcc agggttaata 12000 gtgttcagtg tgtaattgaa acatattcct aagtcattgc aacgttgtac gtatgtttct 12060 agttgttcat tttttacatc aggtaatcta aaatcaggtc tggccgcagc aaaagccata 12120 tctcgtgtgc taccatacac ttcattaata atactattag ggtatttctt gtttaattca 12180 acaattttat caagaagagt taaatcaaaa ttagtcccaa ctttaaatgt atttttcatt 12240 ttgttcctta tttacaaata aaggcctttc ggcctttaat tattttttta attgtgctgt 12300 gacttcatct aattttgtag acatatcttt aaaagtaatg tcatttcctt gcaggcttga 12360 cacaatagtt gacactaaaa caacaaagga taataaaaca cctacacaaa aaacaaaaac 12420 tgaacttgcg gcaccaataa gaaggccaag aactaaattt ttaaaatatt ttaatacttt 12480 catttattgt cctaatttag aattaatata gttaataaca gaatcgtacg gagctgcatc 12540 taaaacatta tttttagaat catgctctac cagtttaaat gtttggatgt tcatattatc 12600 ataaaataaa tcatagaccg aaataatgtc attgaattca tctttggata atttgattaa 12660 atcatcttca aagtcttcgc ctaatctatt acgagttaga cctacaacaa gacattttga 12720 tcttaattta attaaatctt ttacatagtt attaaaagat tcttgatttt ctttaataat 12780 aaatgatttg ttatgatgtt tacgatagat ataataaacc atattactta aaaagcaacg 12840 atccaataca tattttttag tagggtctaa gtgttcaagt aaagtttcaa aaatagctac 12900 ttcgcttctt gtgactatag taaacaatcc ttcagaagtc tttttaggga attctattaa 12960 agtgaaccct tcattttcta ctaaatgttg tattaatgta gttttacctg aattatcagg 13020 tccttcaata gcaacaatat tcattttatc tccggaacgt atggtttgta attagataag 13080 ccagatttag caagcttttt gaatgtacca gggtccatag ccttatcatc tacaattaaa 13140 tcgtaaaacg gcttatgagt taatagattg tgatatttta atccaataga ttctaaatta 13200 gaaaccagtg atggaacaat ttctgtagca attttaccag gacctactga agtcatacca 13260 cgagcggtgt ataatgttat agtatgacct tcatcataaa ggtcattaat aatttttacc 13320 atttctgggt ctggtttaaa attttcataa tccctattgg tattccatag ggttattgta 13380 ttatctatgt caaaaaataa attcattgca ctttagtcca ctgtttaaat aattctaaac 13440 ttccggatgg tttatatttt acatcagttt ctaaatcatg caaaatccat ttttcagggc 13500 atttggtaat aatagaaagt gtaacaccat tttttaattc aggaacctgt tcacctgatt 13560 ttaaagttct tgatttagga atatttttta ataaaaggga aagtttgtat aagccgttat 13620 aatatgcacc caaagctttt aaagggttat ttttaaaata tccggctaaa gccatccaaa 13680 taacagcaat ccataatttg tgtttaaatg tacacatagg aatgtcatct aaaggcataa 13740 ttggtttaac atcaacaaat actttctttc caacaagaca caatccaccc catagtgggt 13800 cggaattaaa ttcgtcgtat ccatcaatag aatataaaac tttggcttcg tcgtaaatag 13860 ccggaccttt tacagaattt ccgaaatatc cacgtgggtc aattatttta atatcaccct 13920 tatcactaaa caaaatatta ctgtagtgtg ggtcaccatg gataaattga tatggttctt 13980 ttttatcaga taaaatttcc aaggcctgtt ttagtaattc ttcagggtct gaaactttaa 14040 catcattgac atgagttaca ccatttggtg caaatccttt aattaaaggc tcaatagatt 14100 cgtttctaat taaaacttta tcaagaactt cttttttaac atcagaatac caggtttcat 14160 cttcagggat aattgggtca ccactaatag attttaatgc agatataact ttatatacca 14220 taagaatttg gctttcttta gtcattaact tataggcttc agccattgtt aagccgtaaa 14280 tacgttccat tttaataaat tcattaggct taaaatcaaa aatagtagga atgaatttag 14340 aatctacatt agagtaccaa ttcatttctt tttgttgcat ttgtttgccg aattcgttgg 14400 ttgggatttt gaatacaact tcaccatcaa attctaattt attaaagtcc cggtttattt 14460 ctgattcttc atgggcttta gctaattttt ctttatcccc aatatcaata accttaggta 14520 atttaaattc ttccatttta aatggcatat tattgatatt atcagctaaa tcttctccat 14580 aaggcccttt aaatccttcc caatttttaa tttgatacat tcctactacg ccaccacctg 14640 taccaacttc attaaattta ttatcgacaa attcaaatcg gcaatcggtt ccaaatgtgt 14700 agcaataatt atgaccccaa tcaacaatat gattttctgg gataatatca caccagttaa 14760 aaaccacatt atggccaata atatcatctt taatagaatc tatagcatgg gcacttccaa 14820 aagaaacatc cacatttcta atagtaatat ctggaagacc cattgtttta atataacctt 14880 taacaagagt gttatatttg ctatggataa ctaagataat ctcatccgat tgaggtgaat 14940 ataaatcaac caggtgtttt aagactgtgt gttgtttata gttaaccata actttaggaa 15000 tttcgcttgt tataggatat aaacgcgaac ctaaacccga acttaatatg acaactttct 15060 tcatttattt ttctcgcaaa ttttctttaa tgtaggaaca tcgtatttaa caacctgaga 15120 ataatcacct gttaaactag cattttgttg cataacacgg tatgtgataa cagctcgttg 15180 ataacaattg agctcaactt ttttaggttg ttccatagga ggaagatttc tgtcttttgc 15240 taattgagca tcaactcgtg ctgaagcttc tgcgatttca gcacgaacac gtaatctgtc 15300 tgcttctctt ttggcatcaa gttgacgttc taattcagct cttgattgat attgtggatt 15360 tttattaaaa taagcgattc cattagatgt tgatgctaac tgcccagatt gttgcattct 15420 agcttcacgt ttagctttgt aagcttcgta ttcagcttgg ctcatacatc cggtcatagt 15480 taaacaaata agtccgatta aaatatgttt cataatatgt ctcctcaata aatttaatcg 15540 gaactatatc acttatttta tagaagcatt aaaaatcaaa taaatcagct aaagaagatt 15600 ttttctcata atcaatttta gcggcatttg taaatgatga taatggttta acaaatgttt 15660 tgttaaaaag ttcttggtaa tcaagattac gtttaacaag ctcttctatt tcttgtggta 15720 aatctgagcc agaaggccaa gagatacatt tttcaccaaa tggatttcct tcttttaatg 15780 gaagaacttt aactttctca ccttcaaaaa taggtggtgc accatctaaa tttttagtcg 15840 aacgattata agctaaaacg cctttaacat ggtatggaca tcctttagtt gggaatcctt 15900 ctgcgtcaga atacttcata agattattag cacttgatac tgaagctatt gagctataat 15960 cgttttctcg gaattgtttt tcaaattctt tataatattc ttgtaatgat tcttcacctt 16020 cttgcaacat acgtcgaata cactctttta gtgcaacttg gcaacttttt ggtgtactag 16080 atttttgtgt ttctagaccc atgattttta attctggggt ttcgtatctg gtaccttcca 16140 tatcccagac atttaatgca tatcgtttct tagcagtcca gaatccacct aatcctttag 16200 ttcctaatgg aggaccagca atagcttctc ggtccataaa catcaaatgt tctctgttgt 16260 tcatgtattc ttttaattca cgataagctg tgtcaatagc gggttccatt ttttctgatg 16320 caaacttaga taagaaatct actaattttt gagtatcgtt attaaattta tgttcaactt 16380 tatctactaa attatctaaa caaacataaa ctgagtctgt atcacctgcg ataacataag 16440 aatagttttc ggttcctaat gttgtattta aatattcgtt aattttgcgt tcaatccact 16500 ggattgcaag ttgtccaaat aatgtaatgg ccgaagcatt tcttaaatca taatatctga 16560 agtaaatatt acctaatgca ccataacaag agttaatcaa taattttctg ttaatttggg 16620 ctgtattaga tgttacaata acccactcac agtattctaa taatttctct aaagattctt 16680 tagaagcagt atttaataaa actttaaagt cttcattaaa atcaaatcgg ccgtcaactt 16740 caggtaaatc attagtccca taagaacctt tatgtaatgc ggctttaaca agttctgcat 16800 tacgtttagc agctaacata tatcctttat gttctttacg ttgtaagaac actttttcta 16860 cttcttcagg aataacacct tgatatgatt tatcatacat ccaaccatta ggagaacatg 16920 aataaacatc tgatggtctt ggcgcagtct tattaatata gtcagccata ggtgcaacag 16980 gaaaacttcc tactattgtc tctggactta tattagcttg tctaataata ctcggatata 17040 ggcttgtaag gtcaaaactt aatacccatc ggtatgcatt aggaacaggt tctttaacat 17100 aagcacctgg atatccttgt cttaaatgtt gttttaattc aggaataact ttctttttag 17160 ctttaagtga attaaaaata atagcgtccc acgttttaat agggctaaat actgattgaa 17220 tttgcatttt tgaataatat ccaagagata atgctaattc aataaattga cgtttcttat 17280 caatttcttg cacacaattc acatcttcaa tattataact aatatatcta ttgtgatttg 17340 tcattcttaa tttattaaga gcacctttat attttagttt acctttacct gtttcaaatt 17400 ccgcgataaa gtctaaatta tacgtaggtt ggtttgtaaa actgaatttc ttgtaaagat 17460 ctaaataatc aaggactgaa acacccatga tatcgaaaat ttgtttatcg ccataaatat 17520 tttgaatgac tttagaacga atctttcgac atggagacat tctttttgca actcgttcac 17580 ctaaaacgtt tgtaattcta ttaacaatat acgggatatc aaatccttca acgttccatc 17640 ctgtaaaaat aacaggtggt ttttcttccc ataaacgaac atattctaat aatagttctt 17700 cttctgtttc gaaaggaaga taaacgactt tatcaataat ttcttgagat aattcgtcac 17760 caccttgatt ttccggtaaa gcagctaatt ttgcatccca tttagagaca ctaccaaaag 17820 cagaatttaa taagtcaaat acataaaact tatcatcaat cgaatcgtaa tgggtgattg 17880 catctatttc gtatagagct agttctggtt taggaaatc agtaccagta acctcaatgt 17940 cgcagtttgc aatacgaatg tattttctat tatacataac gtcataagca taattatcac 18000 taatataggc caatttaaag tcatccatac ccatgacttc ttgacctaca tctttcattc 18060 gcttagacca atcacgtgca tcttggatag aactaaattt tttacgtgta caatactttc 18120 catagatatc tttgtatttt gtttctgttc cttctacaga atgccaaaat aaagatggtt 18180 catattgcac agttcgttgg cgttcttttc catctgaatc gatatatcgt tcaaaaatgt 18240 tattaccgat ttgttcaata tttaaataaa atggtttcat gattttccta gttttaattc 18300 cgagtgatta gaatataaat aaaggccttt cggcctttta gttaatgatt taattaccaa 18360 gt; tatgttcttc tggaagattt aatttctgcc cttcaataat atcacataat tcccaggact 18480 ctaataaatt cgcaatagag tcacgacgtt gaatatcttc ttcagagata tctactttac 18540 gaccatctaa ttttaaaagc tctttaaagt gaacaataaa atatttacct tgtttttgta 18600 aaatatgaca actttgataa agttcttttt tagaattatt tgcaatacca attcgggtta 18660 aagtttcacg aatttttaga aagtcttcag gagtttttaa tttaatttca atcataatta 18720 ccatgccttt ataagtttat tgatttttgt tctatcagtt ttatttttaa taacagcttt 18780 aagaaagtct tcagttacca tagcttttgt tttctttaaa aagtcagata aggttccttt 18840 agctttcatt atcttatagt attcatctgc atctcttgta ttaataacaa aatacataga 18900 aattaattgt aatattactt tatattctga atcatcatta tacttggccc atttgccgta 18960 tcttttacct gcttgtatag ctgctcgata ataattataa tggccttcat ctgacaattc 19020 agaaccatat agattcatgt aatgaacagg aataatacaa tcaacatgtt gacttaaagc 19080 gttatcaatc caatgttttg aatactgttc tttttgttca atagttaaat catctttaga 19140 aactgttatt ccatttaata tagcgaacat aacattttca gaattttctt tataagaatc 19200 tgctaatttt ttaacagatt cccagtcttg attcatccat gctagttcat gttcatttaa 19260 atcaggttcg tcttcaaata aattatacat tccatgttaa tcctactgct aaacttacga 19320 atgtggacat taataaaagt tctgtattag atgctaatcc aaaaaactta tttgcatcac 19380 caacagtttc atacatatga acaacaccca caggttttaa taacggatat aattcattag 19440 ctaattggag aataaatgtt ttaaaatctg gcgcgtattt aatggctaat acacgaagat 19500 cttttatatt ttttgtttgt aatgcagtaa taacatcgtc aagttgtgat ttcttatcaa 19560 caatacgtcc taaaatacct gtgtcaattt taccattgac ggaataaata tcaagctcat 19620 ttacagtttt acgtaaatca ggaaaatttt gttttaccaa atgggctaaa attttaatat 19680 cttctacttc aatattttct gctttacaaa tttctacaca acgtttaatc atatcacgca 19740 tcatagaaat tttatcttca tcagaagggt ctgtaaattt tataacacga gcacgtgatt 19800 gcaatggttt aattataccg tctaaattat tagcagttat aataatagag cagtttttcg 19860 aatatgtttc cataaatgag cgtaaatgac gttgtgcatc acctaaacct gcacggtcaa 19920 attcgtcaat aataataatt ttatttcttc cttctaaaga acctgaagaa gcaaatggag 19980 ttaattgtgt acgaataaaa tcgattttac aatcagcccc attaacaaac atatattcag 20040 aatttgtttg ttttgctaaa attaaagccg tagtcgtttt acccgttcct ggacttggag 20100 atgttaaaat taaatgtgga atacggccct ttttaataag ggcattaaac gtttctttat 20160 catgtttagg taaaatacat tcatcaattg tttgagggcg atatttctgc tcaaacataa 20220 actcgtcttt attaatagaa atcataatat taatttacct taaaatgtgt gattagattc 20280 ttgttccagc acaattacat atttaaatgt aggtgtttca aatttaatag cacctttact 20340 agaaatcata attttataat ctgccattag tactttcata ttattcatat taatgacaaa 20400 tttaaatgtt tctgaagatt cccattcacc gacttcaata gaaaataaca ctttttctaa 20460 attagcgtca acagctttat tgtaaccatt aataacaatt ttattatcta atgattcaat 20520 ggcaatagta tctgcaccaa cagctcgggt catttttgta atttgttgta gatcttcagc 20580 tttcaattca aaaattacgt ctgctactgg aaatccaatc ggatttttag gaactacgat 20640 agtacttaaa tctgctgttg caaaaaacac ttctgtacgg tcatttttaa ttacagcaac 20700 tcgttcttgt tcattatggg taattgtagc atcttcacca actaaggcta aaatatttaa 20760 aaaacctggc aaatcataaa taggcatttc tgaatcaatt tcatctgcga tagttgcatc 20820 agcataaaca gttttattaa ttgcacgtgt cataatgaaa ttaccgggtt ttaaaacaat 20880 acctggatta attgcactaa agtttttaag aatagttaaa gtatctttac taaatttcat 20940 tatattacct tatttgattg tttcaattac agaaagagca gcttttaata ataattctgt 21000 agtatcaatt tggaattttt cttcaagaat atctgttcca ggaataagtt ttgcaccatt 21060 tttgatagct tcttctttat gggctttcat taacttaata tattcttttg atacatcaga 21120 atcaatagac ctataaaaac taaatttggt ttcttttgga agagatttta atttagattt 21180 tttagattct ggtaattgcg atacccatgc ttgacgaatt gcatttttaa aatctttatc 21240 ttttaattta gtttctttaa tcatatacat cctcaacagt ccaataattg tgtctgttat 21300 tcattatttt aggaagttcg tctccgaact tctcttcaag ttgttgtttt gtaaccagta 21360 ttatatcatc tgtatatcta ttgcaaagat aatatttttt aatttctgga taagtttcta 21420 aatctgtaaa taaactcatt gttcttcttt aattgtaaat cgaccaattt tattcattat 21480 aatatgacgg tcataatctt gtggattatg gtcactatgt gaaataata acacattatg 21540 gtcttccata gaattaagaa ttgacattat tcctttagag gcttcagagt ccatactacc 21600 gtcaaaaact tcatctaaaa ataatgtttt tatattaaca ccagatatca ttgatgcaat 21660 gtcatgccaa gtaaataaaa tagcagaatc tattcttgct ttttcacctt cgctaaatga 21720 gaaataagaa aatgattcac gtccacgaga cttaatggtt tctgcaaatt cttcatttaa 21780 agtgacttgg taatctgcgc ctaatttagc taaatgttta ttcaattgct tattaaacaa 21840 aggaatatat ttcgaaatta tagctccttt aataccagaa tcttttaaca tctctgttaa 21900 aatacctcta tgatattttt ccataaccat atcggtttta agtttaacaa ttttatcaag 21960 atcttttagt aaagcttcaa ttttatcaga attatcaatt ttttctttag atgcttgctc 22020 tattgcttca tttaatctat caatattatt tgttgatttg agtattaaac cagtaagggt 22080 ttttatttcc atattgattt cggatatttt ttgttcttga cgtttaaaca tatttagttt 22140 ttgttcaacg tctttagaca tatctgaaag cttaattaaa gccttatcac attttgcaat 22200 agattcttta atcattggaa ctttagatgt cccttggagt tcctgcatac aactaggaca 22260 actcccacct ctatcgtata aagaaataac tcttgagtaa ttttcttttt cagttttaac 22320 tttagaaata gcctgaacta tttttgtcat agaactttgt gggttatcac caagaacaat 22380 agtcttcaat tcttcttgta gtctggatat ttttgctttt gattctgata tatcaagtag 22440 ctgtttatct tttaactctt ggtaacggtc aatgttagca gatgacaatt tctcttgcga 22500 ttctgcaaaa tctttttgtg cttttaattg tgcatccaaa gaatcttttt tagcatctat 22560 aatagcaagt ttttggttta tttcacggat ataagattta ttaagtttat ccatgattcc 22620 tagtgtattt acgtttaaaa gatcttctac taattttctc cgttcagggg tcttttgttg 22680 cataaaaggg acaaaccctg cagtaccaag aacaattgtg tttttaaatg tttccatatt 22740 cattccaatc attaattcaa atttttcttg gaaatctttt acagaagcat cttcatctaa 22800 aggcttatca ttaaccttta tttcaaacac attaggtttt tgtccgcgtt taacaaaata 22860 ttcgtcagaa ccatatttaa accataactc gactattaag tcttttttat taaaagaatt 22920 aattagcatt ccttttttaa taggtctaaa tggtttacca aataatgcaa aacaaattgc 22980 ttctaacatg gtgcttttac cagcaccatt tttgccagta atcaatgttt tatgatgttg 23040 gtctaataca atatctatag gagcttgtcc aacagataat atattcttat attttaccct 23100 aattaattta aattctttca ttatgaatta accgattcca cgtgaaggct taaggcatac 23160 ttaaacaaga tttctttctc ttcatcagat ataccgtcta ttgcattaat gtattctcgg 23220 attattgttt ctaaactttc tacgataata tcttctgaat catctacatc aggtccttgg 23280 acattattct tagaaacaat ttttaaagag tgcacaacag attctaattt tgattcaaac 23340 tctgtaaaat tgtcatccat tttattaaca ataacacgga cagcaatatc tttataatca 23400 tcaggattaa tatcagatgg atattgaatc cgttgatgcc acattgtttt gttctgaaca 23460 aacttggttg tatggtcttt tggattaaat atccatacac ctctagggtc gtcctcatcg 23520 ccggcagtaa ttgaatacgg cgtaccaata tataatacat tgcctgcttc agaaattgta 23580 tggaagtgcc ctgagtaaac tttatcatat ttttttaaga aatctggttc tagaccatga 23640 gacttcatcc ctttataaaa atagaatcca tttaattccc agtgccctat acaaatttta 23700 gcattagaac ttttaatatg gtctaagatt tcttttgtat tttcttcaca catccatggg 23760 attaaatcaa ttaaaacacc ttctatttct actgtggttg gtttatcata aattgtaaca 23820 ttgctgtgct tagataataa ctcagataca gagttgggat gaattttatt tttgaaatgt 23880 aaatcatggt tgcctataat aacatgtaag ttaattccgg cttttttaaa ttcatttacg 23940 ttttctctag aaaattccat tgtgacatga gtgattgctt ttctaacatc aaaccaatca 24000 ccaaattgaa taatttctgt gattccattt agtttacaga cttctattac ttgtttaact 24060 gaatctcttt ggatattttg aatccaaggg tcgtctttag cgaccccata atgtaaatca 24120 cccataaata aaatcatcat aatatccttt gtcaattaaa aattatacca ttttttaatt 24180 ctagcagaat ctgcaataac ttcttcgtat ccatcaaatt tatatacttc accactgcca 24240 acctttctag cagtagtttt tgttaattta acgtagaatg aattagcaaa ttcaaacata 24300 gtatctgttt tgagtttttt aaatgttgat gtctgtatca ttttctttag cttcttcaat 24360 tattttaaac atagctttac gagaggtttc ataacaatat tctagaacac cgcgttctgt 24420 agattgttta taaatcttac gtaatttacc taaagcgtaa ataaactgtt ctttatttcc 24480 acttaataaa gattcttcgt ataaagtttt taaacgatta atttctcgtt tgttcttttt 24540 gagaatcttt tcggctcgtt tttcagcttc ggcttgaagt cttttttcat atttttctac 24600 atcgggtca atactatcaa tggtaatttc tttagattca ttcattatca gtccactcaa 24660 attctaagta taaattaaaa tcctctatag tgtatgaatg attaaatact ccctgtttta 24720 cggaaatatc ttcgtcatat acattaatag gatcaattat cacagggata ttataatgtt 24780 cttttaaaaa aagcttaatt aaatatggta ttgcgtttat atcgttatat tcttcaatca 24840 atggtgttag attgagtttc ttcttcaagt aattcataaa aatcatccaa tgtaggtcct 24900 gtatcactag tctttttaga cccactagat ttaacagaac tttcataaga agttaattta 24960 tcatatatgt cctgtataaa agtttcatca gcaatttgtg ttaaatcact atcaaactca 25020 tcatatacat tatggacaaa atagctatat tttattgcca tttcttttcg ttctttttta 25080 attcgttgaa cgaaggcatt aaaacaagcc atagtgatgt aagcatgtgg attattgtat 25140 ttagtttcgt caaagccata taaacctttt attgtggctt caatcccatc ccaatacatt 25200 tcttgtttcc aagcagctgt atatccagaa aaattatatc gattagaaag accttcagct 25260 ataagcataa tagctcgtcc tatagaatca ggaattttaa cttgatgtcc cgctttataa 25320 catttttgtt tccaatcaca aatctcttta tataattctt tattgttaat ataattattc 25380 atcaagaacc tccaagttaa ttatatacaa aaataatatt ttgcatttgc aatcaaggag 25440 cttcgctcct tgaaattctt tattattaag ttctttatat tatatataac tattaagtaa 25500 taaattaata actatagtaa actattttat taaaagtata gtatattcta tataactatt 25560 aaataataaa ttaataacta tagtaaacta ttttctaata tattctatcc agtcttttac 25620 tattttttgg tcttcttcat tttcaggatc tagttttctt cctagttttc ttaacaaata 25680 catatatcga tatttttctt tatctgtcat ttgatactgt ttttgaaatg agattctttt 25740 tctagtttgt tttattttag gcacttttaa catatagtca gtacatatag tcgaattttt 25800 aaaatacctt tcttttatgt attttgctaa tctcatatca ggaacaaata aattaacttt 25860 tttgttactt ttattaaccc taatatttgt tctggcacat aattggaaag ctggttctaa 25920 atatttagat acaatatatg catccactaa ttcgtcttct tctaatcctg ccgataatga 25980 caattctttt aaaataggaa tttgccatgg caaaggatta aaactaaaca tcaccacaac 26040 gttcctgtaa tcagtgtagg agtttaatcc gtgtggatta tatggaactt caagtccttt 26100 attaaaacgt gccctgtatg aattcctggt gtatataaat ggttcgtcac caatcaaacc 26160 atcaagaata ttttttattc ttgaataatt ggttaagcca ttgacttctt tatctgcatt 26220 atgtttagac caagaatttt caaacatcac atttatttgt attcttgatg tattagaata 26280 ttctttaaat accagtttgt cttctaatgg tgattttaca aaatcccact tattaaagta 26340 cttaagaatt ttaccagtaa aagtgtcttc tatatttgct gcagaaatag tcactttatc 26400 aaacacttcc caatctttac tagaaacatc gttgataaaa taacatgtgg ctccagtttc 26460 agatttagaa atttttgttg gaataccttg taataaagct ttatatagag gaagtaaact 26520 cacacagata tcatctaatt gattaagacc ttgtaatgct aattcttcaa cttcttcttt 26580 atatttttca tttaaaacta aatctgataa tccttctcca ataggcatac agaatttgag 26640 tatttcatct agattatgtg aaaacacaaa tttattaaat gatactaatt ctgggacttc 26700 gtcaatatat aaactaaagc cattaaattt actaaagtct gtaatagata ataaagcaga 26760 atgtgttatg aaaataacat cagatttggt ttcttctata gctttactaa cagatttaga 26820 cccgagttta ttgtcagaat caatcaatac cccttttccg cccaacgagc aaaaataatc 26880 aaaggactgc ttagataaaa gcctcgatat cgaggctata attgattttt ctttattatt 26940 gacaatatgt tctacaatag ctttagtctt tccagcggct gggattgctt ttaagacttc 27000 gattttcatt aattaaatcc atttgcacgt agttttttgt atttacgaat accttttgta 27060 gtaatttctg taggaccttt aatattaggc ttgacaccga acgcctgaat accaaagtta 27120 tttagaattg tctcaaccat aatttctcga ataccatttt tagaaatctg gtgatggtct 27180 ttgttgaggg attcatgaag aatttgttca tgattatcta aaaatcttgg agtaataatt 27240 gcattttctt ctaacatttt ttcttcaacg atagggaaaa tgtagttttt aatttcatta 27300 cgaagtgcct tactcataaa tatctccaat atatgatttt aatccagata aaccgccaac 27360 tggtttatcg tcaataaata tttgtgggta cataatacta aggttttgtt tattaagcaa 27420 ttttgccagt gaaataattg tgtctctatg ataatcaaaa ccatcttcag tattatataa 27480 cacaggaata aaattatatt ctatcccata ttcattacat aacctaatag cttctttaca 27540 tgaataacaa cgtcccacgt cttccggaat accataaatt gttatcattc actaacaccc 27600 aaagaaaggc ttatattaaa ctcatgtaat ttatcagggc cttgtacttc tattttagaa 27660 gtagccatat ttatccagat atattcatat tctatatcat gtggaagact aaaaagatta 27720 tcttctttta attcggcatt taaaaagacc acatctaaaa aatggtccca ttctgtgacg 27780 gtgtcccaat ttttaattcc caatatatta actatgtgat tactcatact cagaccactc 27840 attattaaat tttctataca ttttttgatt atccgaacca cgaaaaggct tatctgttgg 27900 tttagtataa tcgtactttc catctataat aacatcaaca tagtctaaaa gctctaatga 27960 tccttcaggc agatcattaa attcatatcc agtataaatc caaatagatt ttctagtttc 28020 ttcctttact cttttacaaa tattaataac ttcttttata ttagagcgat acaagggatc 28080 accaccagag atagtaagcc cattaatata tggtttatta accatagtga ttaaatattc 28140 cagggttgat tctgtgaatt cctggccatt acgcgggttc caagtagact tattgtaaca 28200 ctgttcacat ttatgagaac accctgtaac aaatagcact gttctaaatc ctataccatt 28260 taaagaatca catggaataa tagatgcata attcatttta tctccttagc aaaaaagggc 28320 cgaagccctt taattaactg tatgcataag cttcattgga ttttttctta taaaccaaat 28380 cagtccttag tgtatcatat tctgggtttt caagcacttt atttaaaata tgtcttttat 28440 ctgctcttga taatttagct tgagccgttt taacttcaga atcaattcct ttccaacgtt 28500 ttggtttatc ggaatggaaa atattatctg caacatcatt agggtcttta tatgctcttg 28560 ctgttcttga agttttgtcg taatagccat tattttttaa tgtttttctt ctaacagttt 28620 tacccataat aattccttat actaatagtc taattaaatc agaaaacccg ttatcttcta 28680 gttttttaat attcttttcc aataagcctt taccataagt aaaatatcca tcttcagctt 28740 ttataattgt actttggcct gtttcagggt ctcttgctat tgctaatcca tatctatgga 28800 gaatagtagc attaataaca tataaaagtc ctaactcaga catatcattc caatctaatt 28860 cttctttttc aggaattata tttgcacctt ttgaattttg catattaagc cttaatatgt 28920 tttgttctat ggataacttc tttttgttta ccttcgttaa acccacgaga agcaggattt 28980 ccaagatatc cacaggtacg acggacaaca gacattttct ttacatccat ttcaccacat 29040 tttggacatt taaacccatt ttctgtagga ataaattctc catggaattc acatgtaaag 29100 cattggtcaa caggagtatt tgttccaaaa taatctagat tttctacagc ataatcccag 29160 acctgttcta atgcatcaag attatccttc atattaggga gctcaacata agaaatatga 29220 ccaccagttg caatacggtg ataatccttt tcaaattcaa ttttctcaaa tggattaact 29280 ttacgttcaa catcaagatg gaaactattt gtgtaccaac ctttatctgt aattccttta 29340 acagaaccaa attctgcctt atctaattta cagaatctgt ggcataaact ttctgcagga 29400 gtcgaataaa gactaaacgc gtatcctgtt tcttctttcc acttagaaag ataatagttt 29460 atttctttaa gaatacgttt accaaattct tgggcatctt tattatcaaa tggttcatca 29520 tcaaaaatta attttaatgt ttcgtgtaaa ccaatataac ctaatgaaat agaacttcgt 29580 ccatttttaa ataatgataa tatttcgtca ttagggttca tacgaacacc aaaagcgccg 29640 ccacaatata aaattggagc cacagaagct tttgcaccac gtaaagaatc aattctagtc 29700 ataagagcag tataacagag gccaagacga tctctcaatg attggatata tgattcttta 29760 gataaattgt cactacctaa ttccagggct attctaggaa gatttaatgt gactacacct 29820 agattattgc gcccatctaa aatttctttg ccattttctt tatagacact taaaaaagat 29880 ctacacccca taggagaaac tgggaccgaa ctaccggtta tttctttatt aattttagac 29940 gaaataatat ctgggtacat tcttttagct gaacattcta atgctaattt tttaataaaa 30000 taattagggt cttcaggttt aagattaatt ccttcttcaa taaagaagac taatttagga 30060 aatatcgcag ttacttcatc tttgcctagg cctttaattc tatttttaag aatagcttct 30120 tggataactg tgccggccca tgaagtagaa gttccaaaag aaatagtcac aaatggcgtt 30180 tgcccattag agctaaaaag cgtattaatt tcatattcgt acgcttggaa agcgtcataa 30240 acatcttttt ctgtcttctt catagcataa tcttcccaat caggaatacg ccattcaaaa 30300 gcttcattaa gatgtttttg gtatgtagct tctacgtaag gctcaagaac aacatcaaca 30360 tttgcaaatg ttgttccacc atattgatga gaagcaactt gggctgtgac ttgggccata 30420 attgcacaag ctacaccaat tgatttaggt gtttctattt ccgcgttacc aagcttaaat 30480 ccattttcaa acataccttt taaatcaact aaacaacaat ttgtaaaagg cagtgataca 30540 ctataatcta agtcatgata atgaataata cctttgtcgt gtgcttctac tacattagaa 30600 ggcaatctac tacgagccac gtacttggaa gcaattccgg ccagcaagtc acgttgtgta 30660 ggaaagacac catagggctt gtttgcattt tctgtagaaa gttcatttga ttcacgatta 30720 catacctcat taatttgaga aattagattc attttaaaga tttccttaaa gcttttttat 30780 atcttttagt taactcggtt tttgtatctg tttctagata ttcaaatccg tttattatca 30840 tttcttctat catttcttct ttagacatcc gagagaactc tttagattta tctattatat 30900 actgtggatg gataggattt tcactgctgt cttgttttaa ataaaataat aaattttcca 30960 tccaagtgat atattctact ttagatttta atcctgaacg attaaattta tgcttcattt 31020 gaccttctgc tgcattacat aatgcacaca ataatccacg gactttacct gcttcagggc 31080 cagataatga atggtcatga tctaaatggt tcttttggac atctttatct aattctaact 31140 tgcaaataca acaaaggccc ttttgggcct tatacatttt ttctttttct tgtttaaatg 31200 attttcctga taataacatt ataacctcta taatttatca tatagaggta tttattaaaa 31260 attataactc accagtctca taccattttt gttcttgttc ttcactatca aagaaacctt 31320 caagacccgt aggtaaagca tttgaaattc tgttcaataa atcatagagt ttattatttt 31380 ggtcttctag ataagcaata cgatctttat cgttcattaa tatattcctt aaatttatca 31440 aatccaccaa tagacacatc atctataaaa atctgtggca tcgttaatcc aacttctgaa 31500 cgtcgattta gacgtttgac taattggtct ataatttttt tatttaaaac aggcccttca 31560 ccttcagaaa ctgggataaa agtgtaatct aattttttaa tatcagctaa tcttttggca 31620 ttaatacatg gaacacattt aaagtgttta gggtcaaatc cataaatttc tactttcatt 31680 tagatggcac cattttagtt aaactttccg ggatagtgaa tacagataat ttaggatggt 31740 caacccaaat ggttttttct acagtaccat catcttctat aataatttct tcaaaaaacc 31800 cagcttctct gaaattatttt ccggctacag tagaaaattg ttctctatta agtccatatt 31860 tagccaatac ttcatctgtt acttcttcat tctttaatat ttcaatagaa gagatgtatt 31920 ttagtggttt acgtgataat tgcataattt gccctattta attaagaaat taatatatgt 31980 ttttataata ctagtaataa attcccaaat ccaaataaca ataaccataa ttaaaataaa 32040 tggccataaa aacattaatt ggaaaaacga atatactaac ttatccgaaa atttttcttt 32100 aatattttta tcaaatttaa atgttagaga tgctataaca aatgataata aaacatatcc 32160 tacaatatat aaaaacatag ttatccttta taaaatgttg ttttacaatg tctacatttg 32220 tattttaatt cttgtaccca agagactagc tgaacctgat aggttccaca tccaggacat 32280 tgtggaatgt ttttagaagc gtcttcacga cgcttaacaa ttttttctac ttcttcccag 32340 ttaataatat ctttatgaag gaccattctt attccttaaa attataataa cttttcactt 32400 cttgaagata aacatcatgg ataaatttat cccagaattc tttatctaca gtctttggta 32460 atccattttt tgcagtgatt ttagcttttc tttcaacatc atctacaatg gattctagat 32520 tctcttgaac aagtttaaaa tcaattttac ctgctttgat atctttaatt tgtcctgcca 32580 tttgtaacgg catcactaaa tcaccagtat catagatttc tgctaattga acacctgcac 32640 gatatgcatg gcttaaagct ttccaatcaa taccttgatt ttcttcagct ttacgggctc 32700 tatcgccata ttcttcccat agcttatata atgatttgta catttcatct acagtaatag 32760 tcatttggta tttacgacct aaaacttcat agaaaacctg agttgtacct ttatcatcag 32820 tttgagaagt gaataaagca aattctaatt taggaagtag gtgtttaata attccaactt 32880 taacttgttc agaaaaatta gatgaagtat atggagtaat tatatcaaga acgcgtttta 32940 agcaagctaa tctggaacct ttaattccat attttgcagc ttgtttacgg acatatccta 33000 aataagcctt catatcagtt gtataaaact tagaacggtg ttttctaata aagtcccatg 33060 tttctggtaa atctgaatga acaaccattt cattaggggc gtggattaaa tctagtgcta 33120 cagtttcgcc acgtgccgcc agggtcaaaa agtattttaa cgaatataat tcatgatcaa 33180 catcagaaga agtgttctta gatgatcctg tattggtatt catattaaag tgttctgtta 33240 cttgacaagt cacaatacta tggccactag ggacaaaaat ttctttataa tctaaatctg 33300 attctggtgt agaggttcca tacaaatggg aaccaaataa tactttagca acggtcttca 33360 ttatttacgt cctttcataa atctaaaaat acccataaca atataagctg gccaaaatat 33420 catatccata ataaaagcca tggcgttatc tttattagtc cattttactc taaggccttg 33480 tctaatttca gtaaccatag aaactaaagc tactaaaaaat gaaattaaaa gatacgtcat 33540 ttggattcct tttcttctaa agatttaata gtatcaagat aaatggtttt agctttttct 33600 ttatccgaaa catattcaaa taggtaatct aaagcctctt tagagatatc tttatatttt 33660 actttccagg gtttataata tgatgcgagt aattggtctt ttttaaataa ttcatctaat 33720 aaaggaataa ctttcatata atagaataaa catgttccta caacttcaga aatatattca 33780 tcttttacag gagttcctga tttaattaga ttgtttgtaa tttttaaatt aaagaaagcc 33840 gttttgcaat cagataaaac tggattatta aaagcataca gatcttcaca taattcagta 33900 atgcgttttt ctgctttctt ttgtttagga gaaggattaa ctaatccacc aaaaatttga 33960 attggtggat aggccgcaat attagaaata aaactttgtt gaattgataa agacataagt 34020 tgtcctataa gattaagctt tcatccatcc ataaacagag tatttgatgt taaaaacaat 34080 tggttctgaa tatgtataag ttcgtgtcat cctattatac ttaattctaa tatctgtagc 34140 gtcaggattt gaaaaaacag ctactggatt taaaccagat ggagttattg aaacatctga 34200 cttaaatttg taatcaatac cattaatttt gtatatttta ttttctttta acataataat 34260 cttaaaattg ttgtacatat tttagttcaa aggctttcat agcacttgaa tcagaaatac 34320 gaattaaaat aggttcttgg tctgaatgct gaataagcaa agttgtatct gttatataaa 34380 gtatagagta ctgttttcct ttagcatttg ttattacatc accaggtttt gcttgaaccc 34440 atgaatagcc tttagtttcc ttacaatatg tcatagtatt catattaatt aattttctac 34500 tgggtccaat tcgtaattca atttctagat ctttaggaat aaatgccgaa cctaaaaaag 34560 aaaaatcgta ttttacctga tctaataatt tgtatacctt acctatagca catcctcgaa 34620 taaaactatc aatttttaaa aacattgaac tgcttaattt ttcaatacca agaattttgg 34680 cttcatacac aataggagga ggtgttgata ctaatataaa gttttctaca gttggtgaat 34740 cctttgtcc gaccgtattt atgtgttaaa ataggcatat taatttcctt gataaaattg ttcaattaca 34860 gatttaagct taagtgcttc ttcttttgtt aaaacgataa ggtcttcatc ttgcataatt 34920 ctaatagccg atttatcaga aatagaacgg ctcacttcaa tgtcgcccat gataaattta 34980 tcatttgtgt tccacataaa aatctccata aaggcctttt ggccttatat tatttaaatt 35040 caataaagtt acaatgtttg tttttaaatg attcgtgaat ctcatcgctt aaagactttt 35100 ctctcacttc aaggtctttt tggatattag tttgatgttc taaacgtttt ttcagtctac 35160 gctgagccat ttttctaggt aaaaagtctg caaacaacca aaccccacca acaacaatta 35220 aaaataccaa agcacctaaa actgcaaata aaattgctcc taaaatataa gcgccaatag 35280 ttaatccagt tcctaatgta atgccaaatg aagctaaaat atgaataaga actgtaccac 35340 caatattggc aaatactaaa gatatacacg aaataaataa tgcactaaac aacccacgcc 35400 cgaccaagtt ccaaaaatat ccacaaatac ttttaggcat actatcttta ggggttatta 35460 attttgttaa tttataatgc caactgtctt ttttaatttc aattttaggt gcaacgtttg 35520 ctaaacgaat atcgacaata tctgaacccc acacacgata tttaatacca acaaccttaa 35580 aattagtgcc atggacatca ccgtttgaat aaactacaat atcgtgtttt aaatctttta 35640 cattttctat aagaacatta gcaacttttg ttgcttcttc tttagtttcc cattccgtat 35700 ttaaacggtg ccatttcgga gtattaccgt cattaatgaa caattcaatt gtatacatta 35760 taattcctta aaagagttta acaatagttt aaatctacgt aattcgtcaa catcaacacc 35820 agatactata agaccactaa attcaaaagt ataatctatt tcatctttat gcttcaattg 35880 aaccaaagtt gttgttctac gatttaacgg cccataatta atggtctttt taattcttgt 35940 aggtaatcct tcatcaattt ctgtctttat ttgcatttaa cctctgatat ttttcttata 36000 ctggttaggc caagtattag aattaaaggc ccaaattaaa acggctagcc atccaaaaac 36060 tgtccatcca aaaacaaaat tagaaataaa aatagaagtt tttgcacaat ggtctctatg 36120 ccatccgata ataaatggta agaaataaaa taataccata cctattaaaa ttaagagttc 36180 cattgttctt cctttttaat taaacgagaa gcataaggga tttcttcatt gaaacgaaca 36240 aatcgttctt tttcaattaa taagcctaaa ccatacacga caatcccagt taagccaaca 36300 tacatgacaa tataatccat tgactcacac ttgatttggt caccaatatt aaatgtacct 36360 agttcagaaa gtttcatata acctacttat tcattttacg ttgaagatca atttgtcgtt 36420 ctttaataag acggtctaat tggtcattag ataaacatac acaatcattg ccttgatgta 36480 aaacataccc taattcattt gtagaaactt taacatcaag atttttgtgt aaacaatcag 36540 ttaaataaaa atgcattatt cctccaaaaa cttctttttg tgtttttgtt tacgatttga 36600 ttctaattca gctttctttt tgtctttgtg aacagaagct ctattaaaat catgtttagc 36660 tacaaaatta tttttcatat tacctcaact gtgaatcttt agaaccccgt ctgttgtaat 36720 aagatgtggt gataatatca tggctttctt gacaagtaca acaataatta caatttttta 36780 ttatttgtct acgacgttca gggatctctt caccgcattc aagacagtat atatcattgt 36840 tgtacgaaga attgaccagg cttaatctgg cccactctat agcatcttta atgacagctt 36900 ctttagttgc aaagccatca tctgaaggac cccatccatt cattttttca ccataaagtt 36960 ataaatgaat cgatacactt catctggatc tttttgttcc cagatatcta atttaggttc 37020 atggccaata atgttttgat aatgtttata tacatttaaa tgatttgaat gtaaccaatt 37080 aacaaaagcc tggccgatac gttggaatcc ttttacggat tcttcattcc aatacatata 37140 ccaatcatgc atatcgcaat aatttaaaag tttaggaact tctttttgaa gattatcaat 37200 aaatatttgc ttctcgtgag cagatagtga ttcaaatttg tcaagagtca tattcaacct 37260 cagaatttaa agtttttaga atgatactgt ttatcctgtg aaacatgttt atcagaagct 37320 tcagcaatac caatttttat aggacgtgca gataaacggt ctttgatatc tactttcttt 37380 tcaaattgcc cacacaacaa ataaaataaa cgttcgttag tcatgataat ctccatttga 37440 tttgatgagg ctatactaat acataatata gccttgtaaa cacatttaaa ttttttcaaa 37500 tccagattcg tcagaatcat tttcatcata aaagacagta taaccttgtt tagataatga 37560 atcgactaaa ttacccataa tctcagtgtt atcttcagaa tgattcattg atagataaac 37620 ataattatta tcaccgacat attcgacata atcattattg gtttttgtaa caacaaaaat 37680 agattttgat aatctattac gagtaaaata tactcgaaaa caatctaaat tataaccaat 37740 aatttcacaa acagaattca ttttgtttct ttcactaata gaagctatag agtttactgg 37800 cataccaaaa ttcagttcat ttgattttgc attcattgta ttgataatga cattaactgt 37860 tttaatggtg tcatcacaga ccacaagaac tttactagat acgctcattt tattttcctt 37920 caaggtcttt aatcatttgg tcaagaatca tattagtagc ttctacaaga atacttttca 37980 tcgaattaaa catttggcca tcggacattt tagaaagctt aaagtaggtt tcccatccag 38040 gttcattagt aaattcaaac tgtttagttg taaaaaactc ttttactttt ttaacatctt 38100 ctactgttac gagtttatta tcctggattt tgttagccaa tgcttgttgc acttgttttc 38160 gttctaaatg gatgacttca agctggtcaa taacatcaga ccaattcttt gtatattttt 38220 ctgcatcagc aaaagaataa aatgcaaaat ttttattata acgttttgaa tcattacctt 38280 taataatagt gttcatatca gataatgatt tacatgtttt aaaaccattt ttatcaatac 38340 aaacaaccca ccagatcagt tctgaactaa aagaaaaact ttcttgatgt ggcttagcta 38400 ctacagtata tttttctacc atattaatag gagtaccata tggggttgtg ccatacccaa 38460 cataaaaagt aaatccagga acaaggtctt caaatttaat attcttaatc atgataatcc 38520 ccacttgttg ttgttgtgat cataatatca tgataaacca ctttgtaaat actttttttc 38580 aataaaacca aaaaaggaac ccgtaggttc cctatgataa tgataataaa tactttgttt 38640 tcttacacag cgacataatt tcatctaaag cagattgacc agcactacat gtcgagtcat 38700 aaatgtcttc tcctaaagaa ataattgtat ctagaatttc ttggtccgac gatattcgtg 38760 ttggaaaatt cctggtataa gtaccaccac ttccaagata gatttctaca aatgtatcta 38820 ttaggtctgg catatcttca taaaaatctt cgtatacttt atggtgggca taacttttag 38880 tctcaaaatg atatgagtgc atatatgaag aacttattaa gcatagtcct ataaattctg 38940 agtgtttagt gcttttaggt tttacaaatg ccgaaaattc attcatcgtg aactaattcc 39000 tttttaaggt tgtacacata ttcttgtgca gcactttttc catcttcgct gcatttgttg 39060 ttttgacagt tagtttcttc ccattttgtt ttaatgaaag cataaaactg tactgattct 39120 tcttttgatg gttctttcaa tttactatac acggacatgg cgccttctgc gtatacgtta 39180 aaatatttat catcagatgc ataggcacta gacaataata tgcttaaaca taatagaatg 39240 cccgataaaa agtaattgtt gaatttggcc atacggcctc caatatctaa gtaatccaat 39300 taatgatata tagatttcaa tttataaatc atcttgacat cagagaaata gttacttagt 39360 tttttatatt gcaaatagtc tgcatggctt tgagtagtat taaattctat ttctgattgc 39420 tttaaacagg gtttaatttc tttcatatga agagccaatt ctattgctga catccgttgt 39480 aactttttct tagaaagcat ttcagtgctc atataattct cctagtcagt ttatattatt 39540 tattaaattc aaaataatgt ttacgacaaa acgaaatata tttatcatca cctcctattt 39600 caacaacctc accttctttt acaggattac cgaatctatc acttttagca gtatgcgttg 39660 cttttcttcc acaataacaa acagctttaa gttcttctaa tttatctgcc catgacaata 39720 aagcggcaga gccttcgaac agttcacctt taaaatcggt ttttaaacca aaacacataa 39780 caggaatatt atggatatca acaaatttag tcaattgaat aacttgttgt tttgttaaga 39840 attgtgcttc gtcaataaga acacatgaag tttttaatgc tgattctaaa tatttttcgt 39900 ataaattatc agaacaagaa aataattcac atggttcttt aataccaact ctactagata 39960 taacccctat atctctggtg tcaatatctg gttttaaaag taaacaaggc ataccttgtt 40020 cggtatagtt attattaaca gataataatt ttaatgattt accagctgcc atagatccgt 40080 aaacaaaata tagttgtgcc atgttaatcc ttaatccatt ctacccacag aacacactct 40140 gcgtctttct ttttaccggt tttagtttta tatgtatata ctactttatg ttctagaaac 40200 ttaataggct tgacatctgg ataactatta gtttctctaa tagattcata atgggataaa 40260 gagagaagtc ttccttctct ctgcatttta aaaggatgtg gtaaatgagt catttaaatg 40320 cacctctaaa agcaaaatat acacaaatag ctaaagcagg gaaaataata acagaaatca 40380 taatattaat aaacatctca ctaagtaaaa attccatata ttcctctaaa ttttctgttt 40440 tagtattaaa taaattacat taacgcaaac ccatatccac atcataggcc ataataaaat 40500 taatccaata aagataatat tttgttttat cttatcatgt ggatatccaa agcaccacaa 40560 aaaattagat acagtgaata atccacaaaa aagatataag gcgataaaaa tagctaaaat 40620 agacccaaat atcatttcaa ttctttaaac ttcattttat catgaccatc aatacgatat 40680 gtcccatatt ggcccacatt atctataata ttaacaacta tttcaccatt gcaaactcta 40740 aacaacctgg ctaattttgt gacttcatat ttgttaataa taaattgggg tcctaaaaga 40800 tctccatgaa ctactctatt gcacccagag acaaaaaatt ttccattagg aatagagata 40860 gagtcggatt tatcaattaa agaataaaag gtagcaccaa aaatacgttt tttaggttgc 40920 catactattt ctatattaga ttttttaagg ccagcatttt ctattaaaga ccctgatatt 40980 ccatataatt taggattgtt atatccagga acttcatacc atgaaaact ataagaacta 41040 aaaaatataa ggcatgctaa taaatatttc attggtttat ccctgctata tatttgtcca 41100 ttaaagcccc tctatatgtt tcacagattt cgctattagg tgctttctca cataatgaag 41160 ataacgaatt ggctttattc ttcaaagctg atattttata ctcagcatct tttttggatt 41220 gtaaaaatcc ttcatgaaaa cttgtactta attctactga tagaatatta atacattcta 41280 tatcatcacc acaaaaatat tttgcaacat ctatagactc ttccatgttg ttagatgcaa 41340 taaccggaaa tgttactaaa aataacaata aaagtttttt cataacttac tccattgttt 41400 ttcctacaat agatttagat ttaagatatt ctgctattgt tctgacttca taagaatatg 41460 tttgtcctgc tttatatttc cagttataac ctgcgttata actagctaaa gctttattaa 41520 tatctccttt atgaactttt aaccatgatt ttaattcaac atggctccaa taagcagaat 41580 tacttctatc taatagttct tcaattatat cagaatcagc tttaggtgtt ccggcttgtt 41640 ttaaccgatt cctaatagtt ttgatataat tttggaacat accataagca tggtggtttt 41700 ttccggtaaa ctaccaaatt agggttttca taccctgaac tttctttaaa cgctatagca 41760 gcaaatatat acccaagatg atcttcatcc ttttcaaaat ctcttgggtc tccgttttta 41820 ttgaattgtt gaccaaaatg atatgcataa ttcagattat catattgttc ataagacaaa 41880 ttatcaggta aatgcactgc actacaggaa atagagacaa ataataatag aactgttaaa 41940 tatttcaaaa tttaatcacc tttgttgaaa ttttagatgg taatctagaa ggattgaaaa 42000 taaccatacg acatgtcaat ccatacgttc cttgtgttcc ttcagaagaa gtaaatccaa 42060 tccatagctt cccatcagta atttctaacc ttgtaggttt gtactctata ttagggtctg 42120 gattttctat aggcatatca ggaagtttac agtaatctaa aatagattct ttagcctgat 42180 ataatttatt taatagacca aaaatatcac ttaattgaat tccacgttct agtgttcggt 42240 cgataatatg actaccaaat ttaatatgga accctgcatt ttctttattt aaatttttat 42300 ttatttctga aaaagcctca gaaaattttc ttcgtgcttt tgcacgttct acatgaatgt 42360 tcattattta gactccaatt ttttaccata atatttatac caatctggtt tttgagcaat 42420 tttttcatct aatcttgatt tagataacat aatatcagtc tcagatggaa tatagtcatt 42480 ataccacgat ttaggaaaaa tgaaatcagt tttttcaaaa gaaacattaa aaccacgatt 42540 tttacattcc tggattaaaa cgttttgtct ttgttctaaa aattttagtt tattgtaaaa 42600 gaatttaaca tgtcctgtac caagaacata atttgcagga attttgattg gtttaccata 42660 agctttaagg gccaaagtaa atacacgtgg aagttcgcga tattcagcga taagatgttg 42720 gtctgtaaga agtgatgggt ctaaaagatt aatacgtgtc atatatcctc cattaatttt 42780 aaggataata taacacgtat ttttattaat gtaaactaaa ttttatcagt aaatgtcctg 42840 ttaataacat cttctttctg ttctgtagtc aaagaattaa atctaactgc atacccagaa 42900 acacgaattg ttaattgtgg gtatttttca gggtgttctt tagcatctat caacatttct 42960 ttattaagaa cattgacatt cagatgttgt ccgccttcga ttcttggagc aaactcaata 43020 gctaaatctt tttgggcaga attaccaaaa gaagtcattg aaactacttc atcttcttta 43080 aaatatttag aagccagaat tctacaatta ttagattcag tatctatcaa gaaaatagtc 43140 ccgtaaaatg ggcctgaaac taattgtctt gcttgaattg ccattatttt accttgtaca 43200 tgtaaggttc tgtagaattt tcatctttaa caaaaccata gaattttgtg tctacataaa 43260 gtgcaataga atttttatgt ttaatccaaa ctaaagaaac taaattttca gaagtactaa 43320 aacggccttt tgcttcattt aaaatcataa tcacattcct ataatatata caacaggttc 43380 atggtttaca catttaacta cgtcagctaa attgttaata aattcattag gatttaagcc 43440 cataggttct tcaataataa aaataggaga atttaaagtt atacctctaa atctattata 43500 gaaactagga ttcattaaag atctattttt aacggatata aattctacat ctttaatagg 43560 cttaatgcca atttcttgaa ttttttctaa ataaagacgt tttgtattaa tagcagttct 43620 tcctaaaaca aaaatatcgc gttttggatt tttgatcttt tgttctaata caaatttagc 43680 aacatctgtt gatttgtatg tctgacgtcc aaaatctaat ttgcattgtc tgtattctgc 43740 tattctagca gcaaatgtga atggcttgag cctttgtatt tcttcttcag ttaagttttc 43800 gcatttattt aaaaatttag tcattagttc taagtagttc atttttattc cttaggcgat 43860 atacgaatga aagtatatca cgaagtttaa gtttaaaaga tataatattt tgaaaattta 43920 gaaaatattg tatcttcttt tgtttttaat accataacag gatatagacc tttatttccg 43980 tcatcaataa tttcgtttat ccaattttca aaattggctg aaattaaatt aataaaacct 44040 tcaggacttc cacgttgttg gtatcttttt atgtattcgt cctttaaaga tacatcagga 44100 actataacat aaaatgggac tttttctttt actaatgctt ctcgaacttc tttgtgtgat 44160 gaagcaaatg ttaaagtctg ttcatatcgc atttctttta aatgcttaat atagttttgt 44220 ggaaattcag atttatcaaa taaagaagaa tcagaatcag atactttaat gccatgttct 44280 aaaaactgtt ttgtggcata gcttttacct gtaccaggaa aagcacacac aatactaata 44340 ttatcaatca ttagtcgact ctttaatatt tttatatttg aaagtgtggg ccatcaggaa 44400 acgatttcca gtctccaccc cattcgattt taacaccaag ttcttttgct gcttgcttca 44460 tagctttagc tacaagttca aacttggccc agtcttgcca tggaatatct ctattaacta 44520 agggtcctaa atctacggca tcgcctgtta aatgacgact atttaaagtt ttagagacgc 44580 cttttttaac attttctttt tgtttttcaa gtgtacgaac gccttcaata accataaaat 44640 ctatttcaga tatctggatt gctcgttcta caactttaac taaatctgga ttaacacctt 44700 ttaatctatc ttttgatctt tgtgataata cgtacataag tttctccttt gttgtcttat 44760 gtacatattt attagattaa agaggcttat aatctgtagg cagtgtttta agcatagata 44820 agaaatattc agtgtcgatt gctaaatctt ttttatcaac ttctaataca tcttcattta 44880 gaaaatgata tttttcgacc atttctttaa aataagccaa aatgtcatta tcacattttt 44940 ttgatacgct aatttcatta tctatagatt caaatccatc ttcatatgta gtatatccaa 45000 aaatactaaa acatagatct tttagttcta atggattttc tatatccgga aagtgctttt 45060 taagaagagg ttctaaatct tcgccatatg ttttaataat acagggcctt aattctaatc 45120 taatagtgca ttctaccata tcatgtttaa tacgaccacc ttcttcaagg tcgccaattt 45180 ctgtaattaa attaaacaat tcatcatctt taataatcat tttttattcc ttattcatta 45240 gtagtattca tagaaatctt ataaatccat gatactacaa tacctttaat aataacttag 45300 attgtgattt agagcaatat ttagggatgt cttttaaatc aacccattta aatgcatcat 45360 tttctgggaa tgttttgcca tatttggtat acatacttgt acatacacat ttttctacat 45420 caggcatatt aggacctttg tataaaaata aatgcatgtt tttaccttta tagtaaaagt 45480 gttcatctag gtctactaaa ttttcagggt cagtaacagt aaaatcagtt tcttccttaa 45540 cttcgcgaag agcagcttct aaagcatttt ctccttcatc aatatggcct tttggaattc 45600 cccaataagg tgtattagtt gcgtgacata aaaggatttt gtcatcttta ataaaaataa 45660 ttccggaaga gatttccatt tttaatcctt aatattcggc atcataaaga cgattaataa 45720 cttcttcaat cattatcatt aatatatgga taaagatttt ctagaactgt ttctaagtct 45780 ttaaacccat gtcgttctaa cgaagatctt aaaccattgg tatcattctt aatcacatat 45840 tcaacccatc ggtctttatc cataccttgg acttcatatt cccaaacgtc attccagttt 45900 tcgaaatgcc aactaccata ttcttttcgg gtatcaaagt ttccagattc taatcctgtc 45960 aatttgatac catcaataat aattgcccat tcaccaaaac ataatgaagg ataacttccg 46020 gaccaatcta cagaaatttc catagtattc cttataaaca aaatacaaca gcagctaaaa 46080 atataaagac aaataatggg atataccaaa ttgtcttaat cacatcatta ggtttttctg 46140 tatcaaacat atatcacctt agtaataaag agtttggcct acaaaaattt tattttcgtc 46200 tacaatgttg tttaaaattt taagatattc gatagaaaca cctaaattta gtgaaatatc 46260 gcctaatgta tctttatacc gaacttcata tgtcattaaa tttgaatcac ggttaataga 46320 tgctgttaaa aagtcaatag aattaaaaac ttttaaacta ataacttcgt cgttaccttc 46380 attataccca ataccacgtt taactataga aacttcagat ccaaattcag tttcaattgc 46440 gccaataata ttccgggtat caaccataaa tcgagactgg ttttctaaag aagtcaaaat 46500 aattttcata atagatcctt accagctgaa ggctaaacca gtaccaactg tagtattaga 46560 ttcactgtca aaggccccgc tcattttgaa tgatacatta ctattttcag gactagcacc 46620 aaagccaaca gcaacagcag aaccagattt ataaccacct acacctagac ctattgtaat 46680 agttttagaa aaatctaatg gaatgttatt cattgcagca gaagatgcaa aaccggcttt 46740 cattttgtcc attttattat caatatcttt attatacata ttccatgatt catttactgt 46800 accttcatgg aatgtatgat ctggggttgg gctaatccaa ttgttgtcag atgatgccat 46860 agcgtttatt gataataatg cagttaatgt tgcaacaact aatgtaattt tcataatagt 46920 ttccttgttt tgtttaagtg gaataatctt aacatataaa agtataaagc aataattatc 46980 tatcaaaaac aaaaaaggtc caacatttct gtggacctta aaagcaactt cttttattat 47040 ttattttaaa tatggcacac ccacggagaa tcgaactccg gttacctgct cgaaaggcag 47100 gggtccttac cgctagacga tgggtgtata aaatgaagga gagtatggga ttcgaaccca 47160 tggagcacct tccagtaccc aacggttttc aagaccgtct cattaaacct ctctgacaac 47220 tctccgagat taaaacaaca tactataaat tgaaccttta ccaaaatcaa tttgttgggt 47280 tttagaatat tctttaaata gttcaaaatc accaattaat tcaggttccc attgtccttc 47340 taaaccataa catgaacagt gggagccatg tacttcccaa aattgtccta atgtatcgac 47400 ataaattaca atagcgcatc cacaataatc ttcacagtca taataggcta aaacaatttc 47460 tttatctgct aaaacatcag gtggaatttg gaattcatta caaatatctt ctttggaagt 47520 aaacaaatcc ataaatacat tggttttcat attattctta caaatattat tcatattacc 47580 ctcacaatta atttggcggt cttaccgaga atcgaactcg gtgctgttcc gtgacaggga 47640 actatgttaa ccaggtacac cataagacct aaaatattac ccatccggtt ttccagtttg 47700 gtgaagggtt gtcacctcta gttttaacct gctagtcaag taataattgc ttatcgtcca 47760 attatcaatc ccgtctaggt tatattacac cacttcctag aataccagag atcttgttct 47820 ggatttaatc gacgtagctt acaccatata cgcctgactg tggaatttgg agcgacctag 47880 gagaattgaa ctcctatctt ctgattggaa gtcagaaata atacccgcta taccaaggcc 47940 gcttaaattt gttctacatc tgtgatttga cccaaataaa atgaaattct atattctata 48000 aattcattat tatggtacga aattaaatcc aattcaccac tatattctaa aatattattt 48060 ttgaaatgta aatggttttt gtcaatagta aattcattaa aatttggttc taaatctttt 48120 gtttgaaatt ctaaaccatt atgttcttgt ttaaaatttt tatgtttaat tgatttaaca 48180 ctaattgtat cgtatacacc cataataata tcctcatgtt atcaaatgaa tatccactca 48240 taagttttat ataacttatg tcacgtctgg tccagaaaat cgaatttcga ataatccgga 48300 accgattaat cggaacgtct aagtggatat tgatttggtc tgtacggaag gattcgaacc 48360 ttcgacatct tctatccaaa agaagtagcc taccagactg cgctacgtac agttatcttt 48420 tagtactcca atttttatca gtagctttat ctactgcttt agaataccaa tttttaatat 48480 cttttgacac agaataacca gttaatatgt ttgcaattga aatactataa aaagccatta 48540 gtaatatgca tgacacaaat cctaatataa cacaaataat tcctaaagca ctcatattat 48600 cctcacaatt aatttggtga cccaccatgg aatcgaacca tgctccaacg cttatgaggc 48660 gttcgctttc aaccagtaag ctagaggggc caaatttggt ggtaccgggt agactcgaac 48720 taccgaaggc cgaagcctgg agatttacag tctcctgtca ttgccgctag actacgatac 48780 caataaaatg gtacacacta caggattcga acctgtgacc tagggcttag aaggtccttg 48840 ctctatccaa ctgagctaag tgtgcattat taataaattc tagtttaaaa cttattaata 48900 atggcaggat atcctgccta aacttaaact ctgtacttat ttataatatc taaaacagtg 48960 gattcgtttt ccttcaattc caagtagatg ttatctctaa cttcagtatc actgatatgc 49020 cacttcatag catctatcaa taaatctctt gggatcatat taaacaattc atttaataaa 49080 gcaacattat tttctaattc tatatcaaat aattcaaaaa tagaatcatg cacagaatta 49140 taaaaatcag tatactctat atcatacttt gataagtttt caataaaatt aatcatatta 49200 tgctcacaat aattggtagg acgtactggg atcgaaccag tgacattcgg gttaaaagtc 49260 cgatgctcta ccaactgagc taacgtccta gatgtgcgta ctatcaggtg tgttaattta 49320 tacgcagctt taattaaaaa tataggtacc taagcaatct atatccacct aattattatc 49380 tggcatttaa tttaaatgat agaacatatt cctctaccac acatgtatta tcctgctctc 49440 aggctagacg attaccatcg ttagcgtata atccatattt ctacgttcca gttattatac 49500 gactttaaat atttgatatt gtacctcatt cgtagggcga catttcgctc ttgtttccaa 49560 gaccaacgag gagttagacc ataatgccta gtatctaaaa ctaataaaga cctaggttcc 49620 tcttgtttac aatatcataa tatttaattt ggcgggcagt gtaggaatcg aacctacgta 49680 aaacagatta acagtccgcc gcttaaacca ttcagccaac tacccaatat atttagcatt 49740 cttatgataa gattctatta taccccaacc cgattctaaa cccaagaaaa tgaaaataag 49800 gtttatttac ataattcagg atatgaccgt ttaaacttgc tgttagaaag caaagccttt 49860 accaatttgt caccaaatct tttcttgaca ctttccccag attcgtcata atctagttta 49920 atgcttttca atattctttc accacccgta aaggtcattt tagcttcata ccccttcttg 49980 ggatcatagt ttatgaaatc taatgtcact ttgacactga gtcctttatt cgcgtcatgg 50040 ttaataaaaa tttgttttct gttatcatcc agaactggaa acaaaatcac atattggttg 50100 cgtgaatatg ttttttctat tttatattct ggtaaagcag attctgtgag aacactttca 50160 gtgataaatt ctttaaatga cttcatttct catcctatta ttttgataaa tcgttaccaa 50220 cgtatctttc cagcccgacc ttcagcaaga cgaactcacg taaaacagat taacagtccg 50280 ccgcttaaac cattcagcca actacccaat atatttagca ttcttatgat aagattctat 50340 tatacccaat tcagaagtat acattgaaat agttttacca tttgtgaact ctataactat 50400 atttataaca taaatagagg tggtattttc gtcagaatta ataatattct tcacttgttg 50460 gtagaagaat atattatcac atatattatg aaagcatatc accgaacttc taaatcagga 50520 ataaccactg taggtttaaa aataacttta taatgataag gggcttgctt tggcactgtc 50580 gacttgttca ataaagaaag ttacattatc agaaagtcca agcatatgtt ttttatattc 50640 attaggtcct gtttgacaga caataccaag aacacgatct gtacttgtat tatcacgggt 50700 gcacttacct tctatttgaa gcatataatc attagtgata ccattataaa atacaatacg 50760 gcgttcaatt ttaaaattat cagaatcttt actcagatta cgtgatacaa catctgaatc 50820 atttgggcac ccagttaata aaaatacagc acctaatact acacatgata atagtttttt 50880 cattgataaa cccttttcgt ttttcttact aaaataactt ggtgaggagt attcataata 50940 taagcaaata catctttatc ataatcacgt gggtggtaat actcatagac cgctacacga 51000 aatccttctt tagtaaatcc taagatgaca ccaatgctaa tgcctttcca gggtcctgta 51060 gatgagaacg agacaatatc tcctacagat attaaattac ctatcatgtc ttctttaggt 51120 gttccctgca ttaatttagg gtgaatttct aattctgggt cattggcata aatttcttta 51180 aacccaattt tattttgttc tttaaataaa ctaaatgctt cattaatatt catttcttat 51240 ctcttcaaaa aattcatcaa ttgaccagtg gtatttttta tgggttttag aaaaacaaat 51300 acaccattgg cttctatttt ggtgtaatca gattcattta cataattaga tatggcacaa 51360 acaaaaatta aagccttcta tactatcaca ccagccatta gaattgaacg cgctattttc 51420 ataacgaata gtatccatta ggattctcca ctactgctga ccaagggctt ttgcgattac 51480 agtgtcaacg atgcctaaat cgtcttcatc atctggttta tagcttgcaa ttttattgcg 51540 aagtcttatt aactgctcta ataactctgg tgctgctgcg attaaatacg tattagctct 51600 agcctgctct gtccctattg ctttttgtag agtatgtgct attgatttat cgccactttt 51660 gt; atgcttaaat tccatatcac cccctggcct ttaacattgc atcggcatat gcataagcaa 51780 gtttcgcata atattcagtg gcctctttaa ccgaagtaaa agcaacgtta ctcgtatcac 51840 tatgagataa gcatccgttc agcgcggcta ttgcgaactt gtcacgtaac tcttctaatt 51900 ctgatgataa tagtttatcc gccatacttt ctccattata tcaataaaat ctaaacaata 51960 taaatccgca attaaacggg ttttgactta attagattaa tataactcat cgtcctttga 52020 agcattattt gctaacgtcc atataaactt tataagcaaa ttctgtttct ttagacgtaa 52080 attcatcaga tctagatgat ctagctactt tcataccgta tttttcggca taagatgcaa 52140 attcggatct atctttaaat cgtaggccat ttgtaaaatc tttatataat tggtgcataa 52200 aggccgaaaa tttatttaag aaatcaaatt ttcctttaac aggaccgaca actaaattag 52260 ttccggaaat agctttaact ttgatatatc tcgtatattt agaaatagca tccgcgaacg 52320 gtcctttaat ttcttttgcc caaatagacc gattaaactg gaatgtccaa ttaccgactt 52380 ttatatcgtt tgcaatatat tcgtaacccc aatctttata gtcttttaat ttcatgttat 52440 taaacaagct ttgatcataa tcccgtttat taggattttc ttcaatcatt tctctagtta 52500 atacaggctt tttagattca ttcaaaaatt catcaaatgt tttcattttt ttattcctaa 52560 tttcgattta ggagtatcat atcatcctaa atcgaatgtg taaactatta ttttaaatat 52620 tcgaccattt tatctaccat atcatcatct ctgacattaa acaaataatc tacttctttg 52680 ctatttttca gtatttgcca ttcacctgca cgatgtcgaa caaaagtata tgctcctgat 52740 ttgaatgaat cactactaat ttttttgaca tgttttatct taaggccttc aacctcggct 52800 catgccacaa tttgttgggc tggggttaat ccataatttt tacgcttaac ttctgttatg 52860 aattcattaa atgttttcat ttttcaatta ttcctctttg gtggtttaaa catactatct 52920 tcttaaatta cgtatgtaaa ctataatttg tctgtccaat ccaaatcaag tggttctgta 52980 tattcgtaat ctaaaatgat aggaacatca aatgtacctt caattttaag ttctccaata 53040 tcatagctca atgttatatg tggagaataa tccggaaagt catgagtacc accaatagca 53100 ataccataat tatgtctata agtgagataa tctgatgtat acttaaaaac taaagcagat 53160 ttacctgact cagttttcca tgtatctaaa gttccatgat ctgctaattt aaaactgcct 53220 gaactaggaa cataaggaac gtttacccta gaatataaaa tagtactatg caatttttct 53280 ctaggaacag gaaacgggac ctttaaatcc cgttgtaatt gttcgattgc atctagtgtt 53340 aatcctgaga acttggcacc gacatatgtg cctttattag gaatcacttc caactgttcc 53400 tgatgcagta ttatcttcat caacaggctt agctggtttt aaagcttcaa tagcatcata 53460 aatatcttga attttaacct gtccttcttg ttcgatttct aataaagaaa ttacattaga 53520 aataatagtt tgaagttttt cttgttcttg cattaattca cgaactttgt cttctgcgtc 53580 aaatgtacgg attttaagaa cattaacttg gacttgtaaa ttttctaatt cagagttttg 53640 agtattcatt ttttaccttt ttataaaaat cgtctaaaga actattattt tcaataacaa 53700 tatcaccttc taaaatttgg aggtcttgct cggtgatatg attatcattt gtatttgtgt 53760 ttttcttaat atggataact tttccattat gtgatctgat tgcttctatt tcatgtatct 53820 gtcgacaatc agtaataaca attgtatggg acttagggat tcttttatta atataattaa 53880 atactatatc cacccaatac attttatcca tgcttacaac aatgtcagtt ccaagggtct 53940 gtaggaactt tctaattgta aattcattat tatttataat aggaatttta ggaatatcgc 54000 ctttaagtcc atttcttttt aaatgggcaa cacatctcaa catataatct tcaaattggt 54060 cttgtgtcat atctaattta aattcacggt caataccgtg accatcaaaa tctttataag 54120 acaaattaac gtcattataa ttttgccaat ttatagacaa tgtaaatttt aaataatcag 54180 caaaggctat tttgtgacaa tatctatttt gttcatcaca taatgattca atataatttg 54240 cacatgtatc tttaccactt ctttttttgc cagtcaatcc tataatcatt tattacctca 54300 tagatggatg taaatttctt ccaatagaaa ttgctgaatc ttggatagac ggacgagata 54360 ctattatttt gttatctttt tcaatttcaa aatatttaaa attaaaatta acggtcatat 54420 aaacagctgg atctccttct gtatcatatc catattctat atcagaaata gaagaaggcc 54480 aagctccata ataattaaaa gatactaatg atttcttttt atcattatct agtatatgta 54540 atatgatacc ttcaggttgt ccagaaacat cccaggcact attattatga gtaatatagt 54600 tatttattga taacatccat ttgtatatct cgatgtacga gaggagctcc tcatctaata 54660 atactttagc tattaattca ccatgttcta atgtagatcc aggtaaattt gatcttccaa 54720 gtcctttcgt tcctaaagga acttctgtaa taggtattct aacatctgga aggataaagc 54780 tttgaacatt tagagtaaaa gcttctgtta atttactatc tggtatatct attctaaagt 54840 tagtagaatt agtttgatta aaaaaactca ttatagtttc cttagtttat tattttatta 54900 aaagtataat atattctata taactattaa gtaataaatt aataactcta tgttattatt 54960 aaaaatatta aaatctggag ctgcgctcca gaaaatagtt tcttctagtt attattttat 55020 taaaagtata gtatattcta tataactatt aagtaataaa ttaataactc tatgttatta 55080 tcttttccag actttagaag cagcaaatct tgaaccttga gacataaatt gttgagtagg 55140 cataaaaata atattagacc agtcttgagg cttaacttct attataggtc ctttaatatg 55200 tccaggtaaa taagctttta tcatttgatc tgagccatgc attcctctaa cattactcca 55260 atttattttt agctttgttt tagaagaaat gttacttgta gaagaaaatc tttttaataa 55320 ttcttctaaa aatgcttgtc tggctttagg tggtatataa tggaggttta aaccatacat 55380 caattgatta ccattacctg ctgttttcgc acctaagaat ataattaaag gaaacttatc 55440 ccaatacggg agagtatctt tatttttggc atcataaaca taagtataaa tcttaccaat 55500 ttctggtgtt ttagtagttc ttgttctaac accagtttta atagtttctt taaaccactt 55560 tatagattta ttgtttactg ctgcaccttc gtttcttatt tttttcttta aagtacttct 55620 aaactcatta actattgcaa gttcgcgttc tcttcttgtt aaattatgtt tagatttacc 55680 tttaatggct tcaacttcta aagcttcttt tattttatct gaatacctgc tcattgcaga 55740 agtaaaagtg ctatatttta ttcctttatg ttctgcaaac tttttagaag atatacttcg 55800 tctcacttta gaaaattcaa cacctaattt aatccagtct tgggccgatt taggtaatgt 55860 tttttcttct tcaatttcaa atatcatcct ttccacccca ttgtctttaa tgacctttca 55920 gtcactatct taaattgtaa attcatttta tccgctaatt ttttagcagc tttccattta 55980 tcagaattaa cttgatatgt atacatttct tccataaatc gtttctttgc tttaactgtg 56040 acattagcag gtggtcttgg tggttgggtt tctttaaatg gtttaacttc aaaaaggaat 56100 tcttggccac ttttaaactt agcccagaaa tccataaaat atcttctttt tttaccatct 56160 gcattactaa aatacggaat tatgacagtt tcagaactcc aagacacaac atcagaatta 56220 ttatcaagcc atttcataaa aaaatgttcc caagatgatc tataagttat ttttcgccaa 56280 tcccctttat atttgtcttt atttactggc aaaaacttac ctttatatgc cataataggt 56340 cctctttata aatacatata taatatttat aacaggcggg ggtaaaatga tattttcctt 56400 ttttgatccg gttgaatata gaggtaaacc tacaacaaat atattcaaaa attataaagt 56460 atacataaaa agagttcttt ctaattacaa attaaaaaca tattacataa agggttctcc 56520 tagacctgaa gaattagcaa atacattata tggcaatcca caattatatt gggttctttt 56580 aatgataaat gataattatg acccatttca tggttggata aaaggacaag aggcttctta 56640 tcaaagcgct atacaacgct acgagaacgc aggtgggcaa caagttctgt accatataga 56700 taacaatggc gaaagatatt ataaccttgt agaagaccct gataaccctg gtttatggta 56760 cgataaaggc gataaagaaa tggagtatct acaatataac gggcctttag ccgctgtaga 56820 tattttagaa gatgccattc taagaaatga agaatcacgc gaaataaaaa taattgaccc 56880 aaaagaaata caatcattta ttagtgcaat tattagagaa atggaaaaat cattatgaat 56940 atacaaaata cttatcttca accatttttt ggtgttgttg aagatcgtat ggacccaaaa 57000 aaattaggac gcgttagagt acgtatatat ggtgatcacc cattttcaaa aacaaaaggt 57060 gacgtagctg ggttagaaac tgaagatctt ttatggttcc aagttctttt accggcaaca 57120 tctgcaacag aatctggtgt tggtaattct ccaactggta ttttagaagg ttcctcagtt 57180 tttggattat atttagacaa atataaaact tctggtattg tattagggac ctgggctggt 57240 attagaacag aaatgcctaa ttacactgaa ggcttttcag acccaaatca acagtaccct 57300 actaaacttg ggaatgattt aaatgattta tctctaggtg gaagaatagg taaagaatct 57360 attgttaacg taattcaaaa tgataataga gaaactgcgc cgaacccatc aaatattccg 57420 gctggcgaag aaccagaaaa taacagccca gaattgacaa tagaaaaaat gttacaacgt 57480 gacgaaggct tgcgtttaag atggtaccca gataatggat acgcaagtat aggtattgga 57540 catttaataa aagcccaaaa aacatcagat cctgatttaa ttaataaatg gatatcagaa 57600 ctagttggaa gaaaggttac taatggcaca atcactatgg acgagtgtat ggctattttt 57660 aaatctgata ttaaaaaagt taaagatggg atagttaaac accctactat tggtccaatt 57720 tacaaaaaat gtaatgcttc aagaaaaatg gctttggaaa atatggctta tcaaatgggc 57780 cttggtggat tagccaaatt taagaaaact ctaaaataca tggaagaaga gaaatgggaa 57840 gatgcttata taaatcttca acaatctttg tggtttagac aaacaaaagg acgagcgtca 57900 agggtttctt tgattattcg taatggtaat ttagaatcat atggtgagaa gacgcctagt 57960 aatgccaggg cattatcatc acaaaggaat ataaacatag agcctgaaga tccttatgtc 58020 cctaacgata cccgagtgat gtttgaagaa ccaaaaacag agtataacag ccaatatccg 58080 tataataaaa cttttggtac tgagtctggg atgattcaag aatttgacga tacacctggt 58140 gccgaacgat atagattaac ccatacttcc gggacatacc aagaaatttc tccagatgga 58200 agaaatgttc agaaaataat aggtgataat tataaaattg ttcaacaaga tgaccatata 58260 cttgttcaag gtgatgttaa attagttatt ggcggtaatt ctaatgttta tataatggga 58320 actttaaacc aaaccataga tggaagtgtt aatcagacag ttcgtggtaa tgtggtccaa 58380 catgtcgaag gaaatgtcaa agcaacaata gatcaaacag ccgatattct tgtaaaagaa 58440 gaagccatgc ttactgtaga aaaagatgtt accataaatg ctaatcaaaa tgcagaaata 58500 aatgttaaag agcaagcaac agttaatgca gaaaatattt ctgttaacgc agaaaagaaa 58560 atggaattta aagccgaaga tgttgatttt agcgcagtaa aaacattttc tgttgattct 58620 ggggttctta ccaaaattac tggtgctaat gtacaggtgg gataatgaat tattacgata 58680 aaatagatga agttgtctca aactttgttc atccatgtga aggagaagtg ccagatgggt 58740 tctatagacg cgttaagtgg gaactatata atccatcaaa agaaaacaaa ggcccaggaa 58800 atggcgaaga gtgggatact gagataatta aaatagggac tagattatat gacgcgaacc 58860 catttgggca taaatcagaa gaattcccgg aaccttctgt agaaggagaa gatgaagaaa 58920 aatgcaaatt ttggtctaaa aaaataggaa tatgcttcaa atcccaacaa gagcttactg 58980 attatgtaga atctataggg tctaaattat taccaggcaa tgattggtac ggagcagatt 59040 tatctaaatc aaatctgttt aaaacaccac atgaatacaa aatgtaccaa atagaaaacg 59100 ctggtggcac ttggtctaaa acaggccctt ctattgataa aagaaccatg ttgatggtag 59160 acaaggatta taatatttct atcaattata atggcgttta tgattcaaga tctgcttatt 59220 tgaaacatta tgaagacaaa ccatgtacat atgttggtat aagattaaac cttgatgtag 59280 atttaagtgt accaggaata cctgaatctg aaccaccaaa aattggagat cttcctgctg 59340 aactcccgtc tttaatattt gcagcaagaa gtttacctgc aattggatgt attccattta 59400 aagctaaatt tccgtataat ggattatcac aagcaatagt tgaagcatgg aatgaatcta 59460 gaagatcttt taaattaatg tgggcagata ttcctggctt acctgaaggc gaaggttcta 59520 tctggagtac catgtattct ggtgtgtcta ttgctatgga agaattagga aatgcttcac 59580 taagtatgtg ccaatacgtt caacaaatgg cttggctaac atttaaagaa gttatttcac 59640 aagcattaaa cattgttggt gcaggatggg atttattaaa atcatttatt cctaaagtaa 59700 ctattcttgg gataactttt gacatagaag atatatgtac ttctggtaat gggttacaaa 59760 aattaaaaga agctttttct aaatttgata tagaaaaagt aatagaagga atatatgcat 59820 ttataggaag tgcctacgaa tattctgtag agtatgtgaa ggtattttca agagacttaa 59880 tagatgcttt aacggattta tacgactatt tgtggtatgt tttaatgacc gctggtgtag 59940 ctttatgcaa aacccttgtt aatttagcag aaatttggtc cattccacca tggattccaa 60000 acccattatg gaatgttgtg attgcagtaa aagaactaat gaaacaaata gaaccattag 60060 atatgattct taaaggtgga tttcctggat ttactgcttc agatttatat tacatggtag 60120 aacgaaaagt caaagaactt attgatgaag catacaccaa aatagaatct ttaaaaaatc 60180 aagccattaa attatgggaa caagtaaaag aggccaaaga taagtggcaa aaagaatcta 60240 taggatttaa acaatacctt aaaggcatgt atggcgctgt cagtgaagaa cttactcgtc 60300 aaaaagaagc tttagtacaa gaagcaaaag atatatacga aaatttatta gctaaatatg 60360 aagcattaaa tataaatata gacacactta aaacttctgt ttctaatgta cttgaattag 60420 cattaaatga attaagaaat cttcctatag ttgaccaaat agaacaatta ttatcattag 60480 taggaacttc atttgatgag atgataacca ctattaaaaa tagtataact ggtgctcaat 60540 cattatataa aaactttaca gatggaagtc gatcactaaa agatatatgt aaatatatct 60600 tcagtcaaat ttctacatta tctttgagta aagttactca atggattaat aaattattga 60660 gtatattcgg tttagaaatt aaatttcctg aattagaact gtgtatacca tacgtaaaat 60720 acgaggaata aaatggattt aattaaaaaa caaataaaca gtattcctga agtatacact 60780 tcagccactt ttgacgagat aaaagcagat tggattaatt ggcttagagg ccaagacgaa 60840 tttaaagact atgattttaa aggctctaga ttaaatattt tattagatct tttaacatat 60900 aatgtgttat atatccaaca atttagtaat tcagccttat atgaatcatt tatacgaact 60960 gcttcattaa ggtcttcagt tgtacaagct gctcaagata tggggtattt tccatcatct 61020 atgactgcgg cagaatgttc tatcatgtta gaatgtacac ataaattaaa tccacaaagt 61080 attaaaattc ctagaggaac caaattttta gcatcatcta aagatggtcc aacacaacca 61140 tataattttg tagttaaaga agatgttaat gttgttaaga gtaaagatgg taaatattat 61200 ccaataatta atttagttca aggacgagtt gttagaactg aattagaata tgacccagat 61260 caacaaattc ttattcgcga taaatttatg gatagacaca ctgttagagt tatggttaac 61320 ggtgtaaaat gggaagattg gacagaaaaa tctattgtta atatttcagg aacaagtcat 61380 gtattctata tgagagaaac aatagatgaa tatacagaga tattttttgg tgaaggtcaa 61440 tctgattatt ctgttgtgga tggaagctta caaagccact atattggtgg attaaaaccc 61500 gttgctggga gcaatattgt aatagagtat attagaactg atggtggaaa agctaatggg 61560 tctattaact ttagttatgc tgatacactt cagtatgttt ctgtagtcaa tattatagaa 61620 aactatgatg aatctgctga ctatatcgga gcctttggtg gtggtgaccc tgaagatata 61680 gaaagaataa gagagcttgg accaattaaa agagaatcac aaagacgatg tgtaactgca 61740 acagactatg aatcatttat ttctgaacga tttggtccaa ttgtccaagc aatacagtgt 61800 tttacagata gagataaacc aggttatgca tttatagcaa ttaaacctaa agaaggatta 61860 agattatcat ctgtacaacg tgaagatatc caaaattatc ttaaagaata taatatttct 61920 actattacac caagtgtaat gtcacctaat tatatgttct taaaacataa agttaaagtg 61980 acgtattcta tgaataaact ttctgaatca gaacaatggt taaaagggca aatcatagat 62040 caaatagata aatattataa agatgaagta gaaatattta ataaaagttt tcacaaatct 62100 aaaatgttaa cttatgttga tgatgcagat atttctattt taggttcttc tgcagaaata 62160 actatggtca gagaattaga aaatttcttt aagactccaa tggctggtgt caaatataat 62220 aataaaatac ttccaaaggg cctattgagc aatgtatttg aatacactgt taatgatgat 62280 ttgtcttatg gagttagatt agcttcgaca gaacctaaag gtgatttaaa agaaggtaaa 62340 attgttatag gaccatttag acaaggcgac atcaaaatta gcccttatct tggaactgat 62400 tttgaaaaat taaaaacatc tgacaatcgt aatagttatt ttgttgttgg taaaatcatt 62460 catgaagaag attatattta ttgggatctt ggacaattaa atgtcacaag tgataaattt 62520 ttagttccaa gtatagaatt atatggaact ccaggagatt ctaatatctt tacaaaagat 62580 gggtcactta ttgtgtttga aaataattta agacccgaat acacagaaat tattatggag 62640 cctatagctt aatgaaagca cctaaagtta ctagtctaag aataataaaa ttatctgcta 62700 accaggttca tattaaatgg gaccctgtag gtagtaattt ttattatttt gtggaactag 62760 cagaatcaag aaacgacgga acgaaagttc cgttagataa actacaatgg cagaatctag 62820 ggtatagttc tgataatgat agattcatta gtattggaat aatccctaat acacattatt 62880 tgattagagt atctgttaga gcaaaggggt ttgaacaatc agattgggca tatacagaag 62940 aatttttgac atttaaatca aacgcatatt cttttgacca tatgaaagaa tttactttat 63000 ctgaacaatt tattaaagaa aaatttgtta aaaataactc aaactatatt aattttaata 63060 ctgaccaatt gttagcctct ttaatgacag aagattttca attcacatcc aaatataatg 63120 atgtatctca aatttctaat aaaatattaa aagaagctaa ttttcatgag atacaaggaa 63180 cacctgaagg aataactaga gtttgttctg atatcaatag agttatgcct gcagaaatgg 63240 atggagtttt atatctattt gaaaggttcc aaaatgttgt taaagtttct aatgataaag 63300 ggcagacatg gaagtattat aaagccctag atgaccgtgt gggtaatcct gtttctaaaa 63360 catgtatata tcaatcagat actacttcat acgttctagg ctatgatagg gtgttttatg 63420 gccgaagaag ttctgatgtt agatggtcca acgatcaaca tcgtttttct gaaacagatt 63480 taacattttc aaaaatagga gatactttac atttagggtt tgatgtcgag gtttttggca 63540 cattatcatt tttacccggt aacgtatcca gatttgctga agcaattgca tccaataatg 63600 attttttata tgttgccgcg ctaaaaataa tttaagattt ttagaccttc acaatgcaga 63660 tgtagatatg gatgaaggtt ctatatcata cggtaaaaaa ttatttgatg aaaagactat 63720 aaaaataaca gataatgaaa atatcgttgt taaaaaaatg gatgttctta atggagaact 63780 ttatatttta gtcacgggtg aagtcaagaa atattttatg gacccaacta aacatgaaaa 63840 tgttatagat tctaaagata aaggcgtata taaattagta gatgacaagc tggttcgtgt 63900 ttttggtaat actgaagaag aacgtagaaa aatagaacac gaatacacta atatgtcaac 63960 tgatggtaaa gaaatcttta ttagttatgc taattttaaa tataccgaat acacaaaaga 64020 cgataaacta gaaaatggca tcaaatacat aaaaactgaa agtggacttt cagataaaca 64080 ttatcacatg ggttctatta gaacttcaga cggtgaaaca tggaaaccat attatatgag 64140 ttattacgct gagccatggt ttacttggat gaatagaaca aaaactcgtg tatggattaa 64200 taatgataat cggcctgtag tggtatatcc ttcaaaaatc tatacaaaga taatagatac 64260 tgtaggtcca actggtgaag atcgtgtagt taaggaagtt tgggataaag gccatggaac 64320 attttattgt aaaaatatat tttttgaagg atttaaacaa tattcaggtg gtgtattaat 64380 ccataaaagt tcaggtgaaa tagtaggata ttatgaatat aattatcgtg ttagagataa 64440 tgcccaaatc atatggattc caaaattaat atgtttacag gctactttac aaaaccaaga 64500 acacccagaa atatgggaac ctaaacataa taaaggcgaa aaagatcctg atttaagacc 64560 tttactaaat acgatgattc ctgatagtta cttattacaa aatagtaatt ttgaaaagtt 64620 ctgtgaatat tacctccaat ttttatctga tggtaaaaac acacattata ataaattact 64680 taatttaatt agaaacaaat atcctagaga aacagattca gtagagtatt tgtggtcaga 64740 aattaacaaa agaaacattt atttagataa agataaaaga gatcaagtaa tacggttttt 64800 tgaatcaaga aaatctgatt tttatagcac aaaaggaacc gaagccagtt ataaattctt 64860 gtttaaactt ttatataatg aagatgttga aatagaaata gaatctaatt ctgggttaga 64920 atatgatatt gtagtttatt ctgataatat caatgaagac atcgtcggac gaacaatata 64980 cactcctacc ggccgttgta atgtcacata tattgaaaga gaatatgcca aaggaaaatt 65040 acaatggcgt atgatattc ataatatgat tgggcgtttt ttagtaggtc aaaatattct 65100 aggcgaaaga agtgatttta aaggacaaat aatccaaggg attaaaggta aagaaatatt 65160 atctaataaa gaagatcttg ctaataggtc tagaagttat tatgtaatga aaataaagtc 65220 taaacttcca acatcaagat attcttctga tgtgttaaga tttgttcatc cagttgggtt 65280 tggttttatt ggaataacat tattaacaat gtttataaat tcaggattgt cccttaaaca 65340 ttctgaaact attatcaata aactgattac atataggtat gattctgggt atccttctat 65400 atggcctgat agagttgcta tattaaaaaa tgatattata gagcgtgacc ctataacagg 65460 agaagcgtta tacacattac atcctaaagc cggtgaagat tttgatattc ctgatgatta 65520 tgacaaaaat gaaggcttta taggaccaga aaaaccatat acaaatatgg aagagtattt 65580 aaaaaatgtt ccaccttcta agagaagaca taagtatagt cctttatttg atcagtctgg 65640 attaacatat tctattttta gagatatgac aaatctactc atccaaagtg ataaatatag 65700 atataaagat aatattaaca atccaaggga ccctgaaaag ccttcacagg agaaagtata 65760 atggattcag tagaattgta tagatcggtt gttacatcta aatttagaac cggtaaatta 65820 ttaagttttt atgactctat aggtgattct gattctaaaa ccacaattta tgttggattt 65880 ggacgacaag aaccatgggc cgaaaacgaa aaagaggtgg gttttgcccc gccttatcca 65940 atagatgatg tatcaggtgt ttctgacatg tggacgcata tgataggttt aatgaaagtt 66000 gacaagagtt tagttgatgc cttgattcca cgacgggatt ggggtgattc aagataccca 66060 aacccgagaa catttaatat tggtgatatc gtagttacaa actcggctcc ttataaccaa 66120 acagatattg gtgatggatg gaaagtttat agagtagtag atattcctaa aactggtgtt 66180 tgttctataa gtaatattaa gaataaagac gagtgtatta aattaggtgg gacttggaca 66240 ccatcatatg aatctgtttt tccaccaaaa ggaagaggag atgcagaaaa aggtggatta 66300 gttgatatgg aagatggata tttatgggaa tatttatata ctattccacc tgatgtatca 66360 attaatagat gtactaacga atatattgtt gtccctacac cagatgaatt aggggaagat 66420 ctagaacgtt ggggatacga agataattta tcatggcaac aaaatgataa taatttagtg 66480 tatagactta aagttgtgac tttacgtttt agagctttta tggactctgt ttattttcca 66540 gaagcttctt ggcctggaaa taacgggttt agacaaatat gtgttgttat aaatccatta 66600 gaaaagaaac aatggcctaa tgacccaaat ataaaagcaa ctaaaaacta ttatcgtgta 66660 tctcaagtag aacgcaattc tggtgaaatg atatatctag aaaacagacc accatataac 66720 aagatctata gaccaaacag aactggtgga tttggttttt agtttttaaa ttaaggagcc 66780 tagtgctcct tttttgtata aataaggata tataacgagg gctcaatatg caagaatata 66840 aaacacttat tgacactggt attaaaggaa attcttcaac aggggatatt ctatacgatg 66900 gatta tatttgatga aacacttcaa ggccaaggaa aacagaaact ccatggaaca gggtattatc 67020 aaaaacatac aagaatgtat tatttagata cccctgaagg agtagaaatg gggtctttgc 67080 acgatgttga cactagtaca ggcaaacttg atataaaact tcctgctgct aagcttggtg 67140 aaggtatcgt tattataaac agcaatgggt ctctaagtaa agacacccca gttattttat 67200 ctacatttgg ttcagatact attgctggac atggtgctag attatcttta gaaatgccaa 67260 aaaaccaaaa caacactatg gtgtacacgt caagaccaag gtatcggcgt atgggaatat 67320 agaatagaat ccatgtttgg taatcatcaa ctagccgttg attctgattt gatgttagac 67380 actacagaaa aaactataga aattggtaac gtagaccact ataacactat aaaattactt 67440 cttcatggtg tatctcaaaa ccaaaagtcg tttaaaagct cagaaatgtt gatatctatt 67500 ttacattctt caggcgaagt ttataaaaca gaatacgcag ttttaaaaaa taatggagat 67560 ctattttcaa tagattttgt tatagaatct ggtattttaa aagccaaagt aaaatcatta 67620 tcaggaaacg ttgcgttttc tattaaatct attgggtcta ttaaggtagg agccgtatga 67680 tacaagtaat aaacattggt aataccgtag atgacggaac tggcgactat ttacgtaaag 67740 gtggccaaaa aaacaaatga aaactttaaa gaaatatacc atgaattagg tgatgataaa 67800 atattacatt ccgccggtgc ttggaaaaca tatactgcta aatctggagc attaacacca 67860 caatttggtc aatcattagc acttaatacg ttagaaggcc cctataaatg taacattgcc 67920 taaagggtca gtagaagatt ataacaaagt tattagaatc cgagacgttt ggaattcttg 67980 ggaaaagtct cctgttaacg tgattgcatc taaaggtgat actataaaag gatcttcggg 68040 ttctaagaaa tttgacaaga acttaatgga cttagaatta gtgtattgtg ctcctgggcg 68100 atgggaatat gttgaaaata aacgtgtaga cagattaact aatcctaata tgtctactgt 68160 aattaaacga agtattattg ctaaacaagg gcaaaaagat tttttagata tttttaatgg 68220 taatctatat aatacacgaa actttgatgt atatcgtcgt ggtaatattt tatattacgg 68280 tgataattct tttgataaag ctaatgccga ttatggttct ccagatgggg cttctaatat 68340 taaagcactt gatggcaaaa acgttagatt aaaagatgca tgtgaagctg gtgatgtaat 68400 tacatttatt tcatttttag atggggttga ttcttggaaa agttcatata atagaaaaac 68460 cgtgacatta gttgataaaa ctttatcttc tgaaacaact atcccaggaa gattaatttc 68520 tgtagacttt acaaaatggc cattagaaat ttcgatgaac gacttcggat tttttgatgg 68580 agaatctgcg aatccatatg cattagaagt tttagttaat ggggttcat atactcaatt 68640 aaatgatgca aacacccagt ctatgtctgg tgactatgaa tttaaaatga caaatggaaa 68700 aatagaggct attgtattcc attcaagatt aaatcataac gataatatag ttttacgatg 68760 gtttaataac gatataggta caactcttcc tatagaagaa ataacatcta taacggacca 68820 aatgtacgtt gcatcagaaa cactcaaagt ttcaaataga atagcatata ctgatacaga 68880 taatccatct caaaaaacaa aaataaaagt tgatgatgat ggagattata aagttaataa 68940 tgtatctaaa atatttgatt tattctatcc aattggaact atatatgaaa atgcccataa 69000 tgctgctaat cctgcgacat atatgggtat aggtacttgg gttagatacg ctgaaggtat 69060 gacactgtc ggttggaatt cagattcaaa tgataaaaac ttccattaca ataattctga 69120 tttaaatgcc caaggtgttc cttctaaaac tgccggtggt aaagttggta aagcttttgt 69180 tgcattagaa aaggctaatc ttcctggaac agaaacaaat gaagatgtat taattaaaga 69240 taaaaatgga actattatca tcggtgggtg ccaatttgat ccagatgatg aaggtcctgg 69300 ctatgacaaa tacagagaag ataaagcaac aacagggact caatctgatt ttggcagaga 69360 atttagttta atacagccat ctataacaac gtataaatgg ataagggtag cataatgaaa 69420 aataataatg tatcacattc atcacctaat tctagtgaaa tttactattc tgtaggtaat 69480 gatactttat ctggtaatag ggttccatta ggaacccaag atacaagaca atcaagttta 69540 aatgtatatc aacctaatgt gcaggcagct ctagatgact ttaagggagc ttttttacca 69600 ttaaatgcat taatctacaa tacagatggt gaaaacccac agggcgcatc tcaagtggat 69660 tttgtagatt ttagtggaac cgttgaagga acaggccctg ttatagttca aatatttggt 69720 attccattac aagttactgg cggaaatact gcatctgaag ttagagaagc atttgaaaat 69780 ctagcccaag acctagtagc taagaatcaa tatttttctt ttgtccaaaa agaatccgaa 69840 acaagattaa cagtaaagta tattgattat agagaccacg atgctataaa tacatatagt 69900 aatggtatta gtgtatcaac agaaattcaa tcacctgcaa aatatggata tgggacatgg 69960 gttaaattag gggttaaaaa cgaaacctta ggagatacag aattaccagt ctacgtattc 70020 aaaaggatag catgatgcaa aatacatata aacatataag tgacagctca tcatttgtca 70080 catttaatcc agtaggaacc caatgggacc aatcaattaa agatgttcaa acagctttat 70140 caaagattgg ttcttgggct atgataggta agggattacc tatttcaaca gaaacattaa 70200 atggtataat tagaaccgcc actagagatg aagttttaaa aggccaaggt tcaggtgcag 70260 taactccaaa atatttagaa gaacgactag ctcatccaca agcaactgaa accgttttag 70320 gattaaccaa atatgctaat aattctgaaa cactagctgg aacccttaat aataaggctg 70380 ttgttccaac tgggttaaag catactttag attccagaac ttcaactgaa ggaagaacag 70440 gtttaattaa aatttcttct ttatcagccg cagcacaagg tgttgatgac acaacggcca 70500 tgacccccta aaaaagtcaa acatgcaatt aatcaattat cgccgtctta tggtatagca 70560 acagaaaaaa atagtggaac tgttaatatt gcttctttag gccaagttgc tcaaggacaa 70620 gcgcatgatg gtatagctgt ttctccaaaa ggatttattt ctactagagc ttctgaatct 70680 caaattggta caacaaaaat agccacagtg gcccaaacaa aggccttgtc tgatgcaaca 70740 ttagtagttt ctcctaaaaa cttaggacaa ttaaaggcat cagagtctga atttggatta 70800 gttaaaacta caacaactat tggtaataca ggggctaatt tagcattaag tccaatggcc 70860 ccagttgttc ctacatctag gacaataaac aataaatcat taacagggaa tattgtttta 70920 aattctgatg acgttggatc atattctaaa tctcaagtat ggactaaatc agaatcagat 70980 gagagatata tgcctaaaac agatattcca aaacagtcat tttatactta ttttgatgct 71040 tggcagttag aaggccaact atcctatagg ccgtggtggg tattgggctg aattaggtaa 71100 aacacgatta ccttttggtg aatatacacg tttacaattt aatatgacca ttaataacac 71160 tagggattta agaccttttg taatgaaaat atataaaaat gatgaagtaa ttaaagaata 71220 ttcaagattc gtgggatatc caaataatta cagttttaca gatagattat taattaatgg 71280 caaatttaaa gctggggatg ttattagggc cgaagccaca gccaatggtg gtcctaatta 71340 ttcgtataat tttaaaacat ggtacctatt attcacataa ggaaatagaa tggataaaat 71400 agaattactt ccactgccat ttgttgacgg cccaattaaa gaccaaacac agatagaatg 71460 gattttaaac aaaaaagaat gtttaaccgg tgcatctaaa tacggtaaat ctgacggggt 71520 ccttaacagg gtcccagctc aattatatga aaatataaaa actctccatg aaaacgatac 71580 attaattaat ggacaagtaa atgaattaat cgattctgtt gacactatta atgaatcatt 71640 agaaatagga aataataaag acttaataaa aactataata gaaactaaag accgtgctga 71700 tatttttgaa agcgttatac aaagtaattc tgacgatata tttgaattag atgaagatat 71760 taaagaattg aaagacgaag ttggagttca taatccagtt gatacagtaa aaagaaccct 71820 tcgtgatgat acgctttgga ttaaaaaaga aataggttct taccctggcc aagacataaa 71880 tggtcaaact tcgcaagaat ctttaggtag tggcatgaaa cgtcgtatta tagatgttgc 71940 tacacaaact gtagataata caaaaagaat aggtgtccta gaaaaaacat gggctgattc 72000 cgatgttggt agtttaacca tagaagttgg taaattaaga gaagaacttg gaaaatcatc 72060 agatcaagaa tatttgtctg tttacaaaag actttctgtt atagaggaca atgtcgacaa 72120 agggtctgaa gttataagcg atattatgac taaaataggc ccaggcaatg tatctgaaac 72180 cgtatctatt aatactcaag aaatatcaaa attgaacgaa gaagttctag ggacatctgg 72240 attaaaaacg agagtttcta gaattgaatc taaattaggc gacgaaacta gcccatttac 72300 tattttatat gatattagta aaaataaaga agggctaaaa gacctaaata ctattgttgg 72360 tgccgataca agttcaggat tacgtggaca agttacatgg atccaatccc aagttggatt 72420 aggagatgaa ccacctgcac ctggtacagt attatctaaa atagatttgt tgactaacag 72480 tactaatgaa cttagtatcg atgttcaaaa tttacagtca gagataggta ataataaaac 72540 cggtataaaa ggaactgtta ttcaattagt caaagctatt gaaggtacag accctgaagg 72600 atcgactgta aaagaaatag gtatccaaaa agcaaccgaa gacatgtatg aagtatatga 72660 caaaggaatg cctcttccac cagaagatgg taaagcttac atttgtagat ataaaacatg 72720 gacacctatt ccaacttctt tgggtgtatt tacggcgaag tatgccaaag ccttagaaga 72780 agggttaaat gatgttgata tatcagaaac tttaattagt aagttgtgtg aacttacaga 72840 cggtaaagta tcagtatttg atagtgggca ttatgaaata gatttcgaat ctcttattcc 72900 aaaagaattt aaagatcgaa aaataaagtt tagtattttt aaaaatgacg aaatgttttt 72960 tgagacaagc gatttaatat caacaaataa ttctaatgtt tttaaagaat caactatagt 73020 tgaaatatca gaaaatgatc aaatccatgt aaaagtggaa tcaacagact ctgatttttc 73080 tgagatatct tttggtatta aattacaaat taaaccatta atataattta aggaccttcg 73140 ggtccttttt ttttggagta aacatggcag gatataatgc gtataaccct aaagaattaa 73200 aagatgttat tttaagaaga ttaggtgcac ctattattaa tatagaagta acagaagacc 73260 agatttatga ttgtattcaa agagccttag aactttatgg cgaatatcat tttgatggcc 73320 ttaataaaac ataccaaaca ttttacgttg gagaagacga aacctataca aatggggtct 73380 ttgatttaca cccatcagtt tttgctgtaa cacaaatagt tagaactaat gtaggttcaa 73440 ttacatctat ggatggcaat gcaacatatc cgtggtttac agatttttta atgggtatgg 73500 ctggtattaa tggtggcatg ggctcttctt gtaataagtt ttatggacca aacgcatttg 73560 gtgctgattt aggatatttt acccaattaa tgcaatatag aagcatgatg caagatatgt 73620 tgaccccaac taccagatta ttggcagaat tcagatacca atcaacttaa agtgatgggt 73680 aattttaagc ccggagatat tataatttgt gaagtttacg ttaaatcata tatagatgtt 73740 cctgataata tgggcgccac ttcaggatat gcctgggcag gtggatgtga agaagaacca 73800 agtatctccg atatatatga taacccatat aaaaaattaa caggctatgt tgctggagat 73860 gattcacaag tccatcaagg gtcttataat aatagatggg taaaagatta ttctactact 73920 ttagttaaag aactaaacgg acaaattttg gctaaacatc aaggaatgca attagcaggc 73980 ggtgttactg tagacgggat tagattaata gaagaagcca gagaagaaaa aagaattcta 74040 agagaagaat tagaattatt agacgggcca gtaggaatat taataggata acttatgtat 74100 gatagcagct tatttgcaaa attagaatca aatgaagggt atcataaaac aaatgaaaca 74160 cagatcctca atccttatgt taacttcatg aaacacggta atacccaaga acttgctgac 74220 gttttagttc aagaaacaat acaaatgaga gggctcgagt tatattacat tccaagagaa 74280 tatgcaaatc tagacctttt atttggcgaa gacccaaatt caaaattcac aaaagcttgg 74340 aaatttgcag catatttaga ttcttttgaa ggatattcag gtgataattc ttttatatct 74400 tcatttgggt atcaagttaa tgaccaagta aaattcatca ttaatccatc tttgtttaaa 74460 catcaggtta atggtaaaga accaattgaa ggggatttaa tttactttcc attggataat 74520 tcgttatttg aaataaattg ggtagaacca tatacaccgt tctaccaagt tggtaaaaat 74580 gcccaaagac aaattgttgc agagaaattt atttattcgg gtgaagagct taacccagaa 74640 cttcaaaaaa accaaggaat agaaatagac gaatttagcg tattagattt agaacccgtt 74700 aagaatttag atggtctggc tgatataaca tctgatgaat attctgaagt taaacaaatt 74760 aataaagaag ctaaagaatt tgtacaacca tattatgttg gaaatggacg tggaacccct 74820 tttgaagact ttgaataaat ataattaaag agaggttaaa atgtttggac attggtataa 74880 cagttcatta agaagatata tagtattaat gggagatttg ttctcccata tttctgttgc 74940 cagaatgaga gacaacaaag taaattatat taaagttcct attacatata aatcaaaaga 75000 acggtttgtc caagtattga ataaatacac gaatccttct tctcaagaaa atattgctaa 75060 agtagaaaca gttctaccac gcatgaattt aaatcttgta gatatgatgt ataactcagg 75120 atataagaca tcccaggcaa atagaaccat gtctagagac aatggaataa ggacatattc 75180 acaatatgcc cctacggctt ttaaaatgat ttttgaatta gggatatata caagaaatca 75240 agatgatatg ttccaaatag tggaacaaat tctcccttat tttcaaccac atttcaacac 75300 cacaataact gaaatgcata ctaaccctat taaacaattt gatagagata taagaattgc 75360 attccagagt gtagctatag atgaaacacc tgatggggat gttaatacaa gaagacatat 75420 agaatggtct attatgtttg aagttaatgg atggatttat ccaccagttg cagatattaa 75480 aggagaaatt aagacggtat atgttaattt ctttaatgag aaagttgaat taaccccctg 75540 aaggtgaatt tgaagactta gaagaatttg aatctgtcga tcaccaggtt gtccctaaag 75600 acgtccagga agcggattgg gatggagaaa gtattactac atattctaga aataaaccca 75660 ttcctgttga tcctgatgca cctaaaccga ggtaattatg agtgaactca atatgaccca 75720 actattagat atttctgatt tgcctggagt tacaggcgaa gaaatcttgg tttatccacc 75780 tcttgaactt aaagaggtgg tttctaatcc tgaaaacaga aatattgatt tagaagaaga 75840 ctacaaacaa acacgccaaa ccctgcatca ccaacaacaa atgataatgg atgcagcaaa 75900 aatattttta gaaacagcca agaatgccga ttctccaaga catatggaag tctttgctac 75960 attgatgtca caagtcacta atagtagcaa agaattactt agaattcata aagaaatgaa 76020 agatatcacc aatgagacaa ccagcactaa aaattcacaa aacgttaata tagaaaatgc 76080 taatattgtt atggcctctc ctactgattt attagaagaa tttggtgatt cttacgagac 76140 aaaagaaaat gcaaaaaatt ctagaccatc ctcttaatga tatcattaag aaccctgata 76200 cattagaaac aaaaatagaa gacgggataa aatttataaa atctcaatgg gatgataaat 76260 ggtatcctga aaagtttagt gattatttaa aaataaacaa aatacgaaaa gttaatatcc 76320 aatcaactaa gcctgaagaa tttaaaacat ttaaagataa agacaataag cgttctagat 76380 atatgggtct tcctaactta aaaagagcca atataaaaac tggttggaca agggagatga 76440 tagaagaatg gaaaaaatgc agggataata tattatattt tgccgaaaaa tattgtgcaa 76500 taacacatat tgactatggt acgatagcag ttcaattgcg tgactatcaa aaagatatgt 76560 tagagattat ggataataat cgtatgacgg tctgcaattt atccaggcag ttaggtaaaa 76620 caacggttgt tgctatattt ttggcccatt ttgtttgttt taataaagat aaatttgtag 76680 gtatacttgc tcacaaaggt tctatgtctg cagaagtatt ggatagaact aaacaggcta 76740 ttgcgttgtt gccggatttc ttacaacctg gtatagttga gtggaataaa gggtcgattg 76800 agcttgacaa tggttctaaa ataggggcgt ttgcttcttc acctgatgct gttcgtggta 76860 actcattcgc tttaatatat attgacgaat gcgcttttat acctaacttc ttggacgcct 76920 ggctagccat tcaacctgtt atttcatcag gtagacgttc taaaattatt ataacaacta 76980 cacctaatgg gttaaatcat ttctatgata tatggactgc cgctgtagaa ggtaaatcag 77040 ggtttgcacc atatactgct atttggaact cggtaaaaga acgtttatat aatagtaagg 77100 atatatttga tgatggatgg gaatggtctg cacaaactat ttcaggatct tctttagaac 77160 aatttaaaca agaacatatg gctgaattcc aaggaacttc aggtacatta atatctggta 77220 tgaagttagc taatttagat tggatagaat tagtcccaga aaataatttc tatcaataca 77280 aggccccaga agaagggcat aaatatatag ctactttaga ttctgcagaa ggacgtggtc 77340 aagactatca tgctttaaat ataattgata taactcaaat gccttatgaa caagttgcag 77400 tatatcacag taatacaact tctcacttaa tattaccaga tattatatta aagtatctta 77460 tagcatataa tgaagcaccg atttatattg aattaaatag tactggtgcg actgttgcaa 77520 aatcattatt aaccgattta gaatatgaaa atattatatg tgattcttat acggatttag 77580 gtgttaaaca aaataaaaga actaaagcca taggttgttc tacattaaaa gatttaatag 77640 aaaaagataa attaattatt caccataaac ctacagtatt tgaattacgg gtgtttagtg 77700 agaaaggggt ttcttgggcc gcagaagaag gttatcatga tgacttagtg atgtcattag 77760 taattttcgc ttggctaaca acccaacaaa aatttactga ttatactgaa aacgatatta 77820 gattagctaa tgaagtgttt aggtctgaat tagaagatat gggtgatgag tatactcctg 77880 ttgtaataat agatgcaggt gaatctacaa cggaatttga ttttagcagc ccgtctatta 77940 ttgggtaata aataatataa acaaatgagg ataaattatg tcatctacat tactttcacc 78000 tggagttgaa tctagggaaa ctagcgtaca atctacgatt gttagaaacg ctacaggaag 78060 agcggctctt gcaggtaaat ttgcatgggg tccggcattc caagttgtac aaattacaaa 78120 tgaagtcgaa ttagtagaca cttttggtgg accaaataac gacactgctg attattttat 78180 cagtgcaatg aactttttac aatacggtaa cgatttacgt attgttcgag ctgttgataa 78240 agaaaatgct aaaaatgcat ctcctttatt tggacaaatt aaatctaaaa tcgtttcagg 78300 tggttctaac tatactgttg gtgataaagt tgttgtaaaa tataacaata aaatcattga 78360 agaagacggt attgttacac aagttgctag tgatactaaa aaaattgaga agatttttat 78420 tccatcagct aaaattattg cacattcaaa agcaattggc acatacccac aattaggtgc 78480 aggatggact gccgaagttt caaaaagtac ttctggtgtt gcaggttcaa tcactttaga 78540 ttctattatt gttgattcag gtattttact aacagaatct gattctgcaa atagtattat 78600 tacttctgaa gaatatatgg aacaaattaa agcttattca ttacctgcta ttgccgctat 78660 ataccccggt gaacgtggtt ctaatataga agtagagatt atttctaaag aatcttatga 78720 aaagaacaca actttaaatc aatacccaga aggtggcgaa aaacaaactt ctggtccttt 78780 agtatttcaa tacgggccac aaaacgaaga ccaatacggg attattgtcc gtgttgatgg 78840 tgttatccaa gaatcaatga ttctaagcgt taaacgtggc gataaagatg tttatggttc 78900 taatatcttt atggatgatt atttctttct aaaggttcaa gtaaattcat ttacgcaagt 78960 tcaatgaatt ggcctaaagg tttttctgga tttattaaat taggtggagg cgtatcatca 79020 aataaaactg tttctgctgg tgatttaatg caagcatggg accattttgc tgatcgtgaa 79080 tcattacatg ttaatttgct gattgctgga tcttgtgctg gtgaatctga agaaatagct 79140 tcaactgttc agaaacatgt tatttctatt gcagatgaac gtcaagattg tttagcttta 79200 gtgtcgccac caagagagtt agtagttaac gttccattgg caaaagctgt ttctaatata 79260 acatcatgga gaaaaggtag aagttcttca ggcgaagccc tggacaacaa tatgaacgtt 79320 aatagcacat attttgagat tgacggtaat tataaatatc aatatgacaa gtataatgat 79380 gttaatagat gggtcccatt agcagcagat atcgctggtc tgtgtgcaag aacagattct 79440 gtagcacaac catgggcttc accagccgga tataatcgtg gtcaaatcat gaattgtatc 79500 aaacttgcta ttgagccaag acaatctcat cgtgatgaat tataccaatt aggaatcaac 79560 cctgttgcag gttttgcagg tggtgatgga tttattttat ttggtgataa gactggagcg 79620 ttatctccaa caccttttga tcatattaac gttcgtcgat tgtttaatat gctcaagaaa 79680 aatattggag attctgctaa atacaagtta tttgaaataa acgatgactt tactcgtaaa 79740 tcgttcagaa tggaagtttc tcagtatctg gctggattaa aatcacttgg tgctatgtat 79800 gatttccgag ttgtttgtga tactacaaat aatacacctg cagtaatcga tagaggtgaa 79860 tttgtagctt ctatatacat taaaccggca agatcgataa attatatcac attaaacttc 79920 attgctacta atactggcgc tgattttgat gaattaattg gacctcaaca ataataaagg 79980 ccgaaaggcc tttaataaaa ggattaaaca atgaatctta cagatttaac acgtgccttt 80040 gaatcaggag atttcgcccg tccaaacttg ttcgaggtcg aaattccatt cttaggaaat 80100 aattttaaac ttaaatgtaa agcagctaca atgccaccaa gtattgtaga aaaaattcct 80160 gttggatata tgaaccgtaa attaaacatt gcaggtgatc gtacttacga tgactggact 80220 attacggttt ataacgatga tgcacattca acaagacaaa aattgttaga ttggtcacat 80280 atgacccata tggacgtggt gatgagattt caggctcttc acctgcagaa tataagaaaa 80340 ccgctttagt tcgtcagttc catcgtaacg gtaaagatgt tacacatgaa gaaactgttc 80400 aaggaatttg gcctactaac gttggtgaag tccaattaga ttgggattca aataacgaag 80460 ttgaaacatt tgaagtaaca ttctctgttg actggaccga ataataacgg gcctacgggc 80520 ccttattaat ggatataaat attagtaaca atggagatat tatgtttgaa actttaaaaa 80580 tgtttagccc ttgggctaaa gaagaccaat caacgtataa ccaaataatt aataataaca 80640 acgattctat aacaggtcct aaatttgatg acggtgctat agaatatgaa tctgattcat 80700 cttcatataa tgttttaatg cagcaattct tcggttctaa tataagtcca gaagttaaaa 80760 atacaacaga cctaattaaa acatatagag ctttagttaa cattcatgaa gtagataatg 80820 ctgtttcgga aatagttaat gacgctatag tttttgatga cgacgaagaa gttgtatcaa 80880 taaatttaga tagtacttca tttagcgatt ctattaaaac aaaaattcaa gaagagtttg 80940 attcagtttt aaatatttta gattttagaa gaagagccca agaccatttt agaagatggt 81000 atattgattc tagaatttat ttccataaag tcattgatgt taataatccc aaaaaaggga 81060 taatggaact tagaagatta aatcctttta atgtacagta tgttagagaa atcataaccg 81120 aaactgaaaa taacgtcaag attgttaaag gatataaaga atctttcata tatgatactg 81180 gaaacgaaag ctatactatt ggtggaagaa tatacggccc taatactaaa atctctatac 81240 ctaaatcagc tattgtctat gcacattcag gattagttga tgaatgcggt aaaaatatta 81300 ttgggtattt gcatcgggcg gtaaaacctg caaatcagtt aaaattacta gaagatgcca 81360 tggttattta ccgtattact cgttcacccg aaagacgtgt attttatatt gatactggta 81420 atatgccaaa taaaaaggca actcaacata tgaacaatat tatgaatggt ttaaaaaacc 81480 gagtagtata tgatgctacg accggtaaaa ttaaaaacca gcaacataat atggctatga 81540 cagaagatta ctggttacaa agaagagatg gaaaagcagt aacagatgta acttcattgc 81600 ctggcgcaac aggaatgaat gaaatcgaag acgttagatg gtttaatcaa aaattatatg 81660 aagccctaag aattccgtta tcaagaatcc caaatccaca aggtggtgtt aatttcggga 81720 tgggttcaga aattacacgg gacgaattaa acttttttaa atttatcaaa attcttagac 81780 accaatttga agcaattctt tctgacccac ttaaatcaaa tttaatcctt aaaaagatta 81840 taactgaaga cgaatggaat gaagaacgta ataatattaa aatcgtattt aataatgatt 81900 catactttac agaacttaaa gatgctgaaa tattagaacg tagattaaat atgcttcaaa 81960 tggtagaacc atttattggt aaatattaca tctaatcgtt ctgttatgaa agatattctc 82020 aaaatgacag acgaacaaat agaacaagaa tttaaacaaa tagaattgga atcaaaagat 82080 tctaaattta ataatgaacc cgaggaattt taaatggaag acatgatttt agcaattaaa 82140 aacaaagacc ttgtagaagt taaaaaactt ttttctgaag gaatgaaaga aaaaatcggt 82200 aaattgattg aatcagaaaa aataaaacta tgtcaaaaca ttgtcattga aggcgaagaa 82260 aaagaaagcg atgaagatga caaagatgaa gaatcagata ataaagataa aaaaactgat 82320 aaagcagaag aataaaggag atatcttatg attattgtcg aaaatgattt tgatatcacc 82380 atggaaaata ttgaacaatt ttctgaagaa gcgtctatta aatttgacaa tataaaagcg 82440 ctagaaaaag atgatataaa tagaattata gagaacattg cttctagtgg tgaatacggc 82500 ttagccattt gtatgggttc attaaacgaa aatatgccat taaatgaata tattgttaaa 82560 cacgtatctt ctaaaggtga agttacaaga accaaagata gaaaaacccc gtgaacgaaa 82620 cgcttttaaa acaactggtt taagtaaatc taaacgcaga caaattgcaa gacgcgcagt 82680 taaaacaaaa cgtgcaaatc cttctattca aactagagca ttaagaaaac gtaaaaaagc 82740 tcttaaacga agagaggccc ttggattatg agtgaaatgc ttttaatcga agactgggga 82800 ttaccaggtg aaaccttaaa cggaacaccc ttaattgaat cttcagaatc agacggcacc 82860 ctttatatag aaggtatttt tatgcaggct gaagtcgtta atagaaataa acgtctttat 82920 cctaaaaaaa tcttagaaca agccgtagat aaatatataa aagaacaagt taattctaaa 82980 caagctttag gcgaattaaa ccacccacca cgggcttctg tggatccaat gcaagctgca 83040 attttaatag aaaaactttg gtgggaaggt aataatgtct atgggagagc tagagtcatt 83100 gaaggcgatt atggcccagg agataaatta gcagctaata tacgagctgg ttggattcct 83160 ggcgttagtt ctcgtggatt aggatcttta aaatcttctg gaaaaggtta taacattgtt 83220 caagaagggt atagattaac tgtgggtgtg gatgttgtat ggggcccttc agcacctgat 83280 gcaatggtta ctcctaaaag gattcaggaa tcaacagata ttcctaaaaa tatagaaaat 83340 agtgctgata aggcattttc tttattatca aaacgtttaa aagaaacgtt ataaataatt 83400 atgtaattta acaacaggac ttaaaaatgc ttaaagaatt tttaattgaa gaagcagaga 83460 aacttaatga cgtttctgta gctctagatg gcattttcga atcagttgaa ttgtctgatg 83520 atgtaaaagc ccaattcagt actgttttcg aaactgcggt aaaatctaat gctattaaat 83580 tagcagaaag ccatatcact gaattaattg aaaaggctga aacaaaagaa caagagctta 83640 aagaatctat ccaagaatct gtagaaaaag aaatggcaga aaacatttct aaatttatgg 83700 atcatgtttc acaagaatgg ttagaagaaa ataaattagc tgtaacaaat ggtattaaag 83760 ctgatttgtt tgaatctatg ttccagagta ttaaaaccgt agttattgac cataatatta 83820 ttcttcctga agaatctgta gatgttgtca aagaaatgga agaagaactt gaagaaagta 83880 aatctgaagt agcttcactt ttcgataaga ctgtatcttt acaagaaaaa gtaaactctc 83940 ttgagaaaga aaaaattatc aaagaacaaa ctgccgagct gactgaatcc caaaaagaaa 84000 aagttgctaa tttgattgaa ggcattgctt atggtgaaaa attcaaatct agtttagaag 84060 ctattgtttc tatggtttct aaatctacag aagaaaaagc acctatttct gaagatataa 84120 ataatgatga gagtggtatg aactataccc cagaaaaacc agtcgttaaa aacgacccaa 84180 tgagtgttta tacagctgcg gctaaaaaaa tcaattaatt taatttaaag gtattaaaat 84240 gtaaatcaaa aataaagatg cattaatcga aaaatggggt gattttatga acaaccctga 84300 ccttggagtt attgaaggta ctactaaaca ggctattatg gccaaaatcc ttgaaaacca 84360 agaaatggac attcataaat ctccagaata tcgtgatgaa aaaattgcag aagctttcgg 84420 cgatttttta accgaagccg aagttggtgg tgaccatggt tatgacgcta gcaatattgc 84480 tatgggtaaa acaagtggtg ccgtaacaca aattggacct gctgtaatgg gtatggtacg 84540 tcgttcattc ccctaacatg attggttttg atatcgctgg tgttcagcca atgaatggac 84600 caactggtca gtacttctca ttacgttcta tttacggtga agatccatta gcaaaagatg 84660 ctaaagaagc attccatcct atgtttgctc ctgatgcaat gtacggtggt cgtggttcac 84720 acgagaaatt tgaaaaaatc gaagcttcta aagaattaac agaaggtaaa gtatatactt 84780 tcgaattcgc agaaactggt acggctcatt tacaagcagt tgaaactgta actatcgcag 84840 atacagaagt tgaagccgat gtacttaaga atttagaagc tggtaaatta gtagaaattg 84900 ctgaagcaat ggctacaagt attgcagaat tacaagaaag ttttaataag tccaaagata 84960 acccatggga cgaaatgact ttccgtattg acaaacaggt tgttgaagcc aaatcaaaac 85020 aacttaaagc aagctattct attgaactag cacaagattt acgtgcagta catggtatgg 85080 atgctgatgc tgaattaagt tctatccttg ctacagaaat tctgttagaa atgaaccgtg 85140 aattagttaa ctggattaac tatactgctc aacctggtaa aactggtatg actttaacca 85200 tgggttcaaa agcaggtgta tttgacttcc aagacccaat cgatacacgt ggcgcacgtt 85260 gggcgggtga aagctttaag gctctgttat atcaaattga taaagaagct gcagaaattg 85320 cacgtcaaac tggacgtggt gctggaaact tcttaatcgc ttcacgtaac gttgttaata 85380 tcttagcctc agtggatgtt aacgttactc cagctgctca aggtttagca cgtggtctga 85440 atacagatac aactaaagca gtatttgccg gtgttcttgg tggtaaatat aaagtttata 85500 ttgaccaata tgcacgtcaa gactacttta cagtaggtta taaaggtgct aacgaaatgg 85560 atgctggtat ttactactgc ccatacgttg cattaacacc attacgtggt agtgatccta 85620 agaacttcca accagtaatg ggcttcaaaa cacgttatgg tattggtatt aacccatttg 85680 ctgattctcg ttcacagtct ccaaaagaca gaatcacttc tggtatgcca tcactggatt 85740 caattggtaa aaatgcttac ttccgacgtg tatgggttaa aggttgttaa tctttaattt 85800 taaataggga cttcggtccc tatttttgct taaaaatccg tggttggatt ataaatatta 85860 gtataaccag aaggaaattt aatatgactg ataagattca aaatttattg cgcgaatcaa 85920 gtacaactgc gggttcttca aatggacgtc cggatcttgt tggattaact cgcgcaacac 85980 atgatttaat attcactgat ttaattgcta ttcaaaatac aaatcagcca gaagcgacac 86040 tttacggtgt taaatattta aatgacaata accaaatgag ttttatgaca cccgctacat 86100 attcaggtgc tgtaaaatct agagaaaata ttgaagaact tgatgtatca aaatcttatt 86160 ctaaaggtga tatggttaaa ttagatgagg tggtttataa agtagtacta gataacccat 86220 ttaaagattt aggttcttta acaaaagaag aggctttagg ccaggccatt attgatggtt 86280 caattagatt tatgtcagaa gcggctttaa cagggcattt tgaacaaaaa aatgtagaaa 86340 ttgctgaagc ttctgttata ttagatagat ggaatattcc tgtaagaact agaaaaatta 86400 aaacagaatt aaccgttgaa tttgcacaag atttaaattc aagtcaattt gaatcaggtg 86460 ctgtaattga tgacatgcta gctactattt tagctgaaga cgtaaacaaa gatgttattc 86520 aaaaaataat gactgtttct agtcgatata aagttaaagg aatttctgat aaaggaatgt 86580 tagatttaac taaaacggat gtggccccag aacaaggacg tactttatat cgatacattt 86640 gtgaaatgaa tgcttcgata gaaagaaaca ctacctatga tggaacatat gttttggcta 86700 gttcacgttg tgcagctatt ttatctgctt ctggttggat ggatattaat ccagattatc 86760 cattagcggc aggaacactt aaaaatggat taccggttta ttctgaccca tggtctcctg 86820 tagattatgt tgttgtcgga actaaacaaa atttaggtga attagaacat gttggttcat 86880 tgttctacgc tccttatgtt gattttgatg gggctggtgc gtataaattg gttgttgacc 86940 cagacagttt acaacctaaa ttggcattaa tggtacgtta tgggctttct attaacccgt 87000 acacagttat tgaagtagac gataaaccac aaaaagaatc tatgctaatt caaggagatg 87060 actgggataa tttagttggt aagtctaaaa tgtcttatat cttaggtgtt caattaccta 87120 aacttataga ataaatttat ttaatttccg gtaatttatt accttttttg ggaacttagg 87180 ttcccttttt tattaaaaaa gccaatctaa actaggatct gtatatccta tcatttcttt 87240 aaattcttcc attatcataa aattatttaa attataggtt ttaatcccta atgatctagc 87300 taaataaaca gctgttcttg taccaccaga aacatttcca aatttatctt caggggccca 87360 aaaaataacg ctatctacag ggtcttctaa tgtagggctt aatatttgca tgcaatttcg 87420 acattgcaga tgtttaactg ttttagaaca tgaatctaat tttggataga accttcttat 87480 tatattagca cttttgtctt gtaattcttt attaaaatca gtaaatacat gaacatcttt 87540 acttctatag tggttattga acccttggtt aggtataata atacatctta aatcatgact 87600 atattccttc ataaaattgt aatcactccc aggcgcacct cctgacaatc ctaggacacc 87660 ttgatctgat atgtattttc caccctttat taaaatatta tataatttag taggaatttc 87720 tcttgaccct attaaagcaa cagaattttt aatcataata taccctaaag gacccgaagg 87780 tccttcattt aagatttaac aatcaaagcc gcaatagttg taataacaat tataataagt 87840 aaaatacttg ctgggatcca taatggcgat aatacccacc accaagacca tgtaattgtt 87900 ccaacaagtt taagaacaac aaaaataaga gttaaaattt gtaaaaaccc gatatttaat 87960 ttcatattac caacctgata tattaatgac attagagtcg tattgggtac gtttaacttt 88020 aagaccttct tcttttagta cattaattac tgcttcttgg actatataag aagattcgtc 88080 aaaggcccaa tttaaatcag tgtgtcctga tttagcccta aaaagaagtg agtttttaat 88140 ttcattaagt ataacttttg aagctaaatc tacttgttca ttttttactt taataagtgt 88200 atcaattaac atataatatt cacccaatct tttctaataa attcttgaac ttctttttgg 88260 atagcttttt taattaaaga tgggtcatca tattctaaaa tatcattacc atctttaagc 88320 atatctttaa gaatatcttg catcattagg ccttgaactt taccaaagtc tttagtttta 88380 acttcaccaa tatgacttaa tacattagat agtctttgtt ttgtgatata tgctgtagcc 88440 gtattgacaa gttcctggtc atcatttgac aattcaacaa ctggttttac tttacgaact 88500 tttccggttt ctttaaataa ttcgtttttg cacttaaata taacacgact tttattatta 88560 aattctacag gaagtacggg ttttaataca taaccttctg cgatattatc tttgcctttt 88620 ggttgtggac caaaaatggt tgaattggct tcaggaatac catgttcttt agcaatgcgg 88680 ttaaattcag gaattaaact atcaaacgct cgttctaaat tggacaaatt atcaaaatta 88740 cctacagtaa taactggaca aattttaaac ccatgtttag aagaaaggaa tcttataaaa 88800 gctgcatcaa ctaaatttcc attaattaga atatcgaata cccaaaaatc tttttcttta 88860 taatcaactt cacgttgaat accagggcca gcgtattcac caaaaattgt taattcttct 88920 aaatcgggca tagattcttt aagaaaagaa tacatttcta aaatatttgt tttataccgt 88980 ttaagaatta attcatatcc aaaaaatgat tcagtttcgc ctataacact agttcgttta 89040 gcacatacta catctttacc atcacaaata aaactaaaat tagtaccatg gactttttct 89100 tgagcaatcc aaaaaatacc aggagaagta aatccttcaa aaaatgcttt ttcaactaat 89160 tttttgttat caatattctc aatagaacca tatttaataa atttcatatt ataccttaaa 89220 tagtctaatc tgtagttctg aaggaatttc tgatgtgtat ttgatttcta aattaaatac 89280 ccgtccactg taaataacta atatttggtc tggatttttc tctgcccaat caatattatc 89340 aggtccaata atattaagca tctctaaatc agagaagcaa cttaatgcaa aagctttttt 89400 taggaatgta tatatatcgg cccatttagt ttcatcacaa atggctggtt tagccactga 89460 taatttatgg gtataacatt ctttatcaca ccaacgtgta aaaaatgctt tttgtttttc 89520 ttctaaagga ataatacctg ccgtatacca actcataaga accccttatt tagatggaac 89580 aatgcggaat ttgtattcac caccacgagt aaatttaact tctaactgag ttgattcacc 89640 aacataaaga accaaaattg aatctttatt agaacgtaac cagtcttggt actcttcaaa 89700 agacttacgt aaagctggga ttttttgttt gtatcggcct aaaataaccc atgcgaattc 89760 accagaaccc atccatttag ttttacggct atattttaaa aggttttcaa tatcaatatt 89820 cagccatgtt ttaaaatttt ctctaatcat tttcttacct tcattcgttt acgataaacg 89880 attttttctt tagatttaaa ttccttctgt ttttcttcaa cttcaatgaa aacagaagcc 89940 atttctttag cagttccacc catttttcta gctatatcaa caaagtgcat accttgttgt 90000 ctaagaaagt ggatttttat tttatcggaa ttagtcatta ttttcttcaa aatctttaca 90060 gatatccaag agttttttgt ttaaagcttc aacaaattct gtagctgatt ctgggtattc 90120 gttaaataaa taacacaaat actcactatg tatttcatgg gccacttgag aaaccatagt 90180 attaagttct ttattcatat aatcacctct caataatgtg tattctatca tctaaaatat 90240 caataagcac agattcaacg ttatcccaat ttaaaccacc attagaacac ccaggtttag 90300 gtaggagaac tcttttaaaa ttgttattag atactatatc cataagttct aaagcactct 90360 ggcgtatcag agataaatca gatttatcat accagttata cttagtagga aatgaaatta 90420 aacttatgtt attatgtttt gtaagaattc ggcatacgtg gccatattgt attaatgact 90480 tagccatgat aaggtctaga ttattaacct tatcagaaaa gagccgggct ataccagctc 90540 ccattacagc tcttttattt ttcttaatat tcatattagt agttatacat attgcatcac 90600 aaggaatatt aagaatatcg ccttttatca ttttcataaa gcatatttaa gatgttcaat 90660 agcatttaaa atttcagatg gtattccacc acgtggatga tgatgaatat tgtcaccata 90720 atgtctaaaa tccataccaa ttacacgaac tttatacttg gtttcatgca aatactcatc 90780 tttataacta gaaccccatg tattagagct tgtaacttct tttgtttcaa aataagtaca 90840 tccacgatga caatagttat cccaaaaatc aacatcttta ttaaataatg gatgatcttc 90900 gcgaattgtt aaataaacag catagtccca atctggattt tcttgaaata actttttgta 90960 ttctacaggc aatccaacat accaagatgc tacttcaatt gcttcgcctt tttgagtatc 91020 attatgtacg gtaaaaacat attttaatgg gttcattata agtccttatt agttaagata 91080 atcaattcac aatcttcagt taaatcacaa aaatttaagg ctaaagaagc aatgcctgga 91140 tattcacaac tatctaccag ttcttcagta ttgttattag caatatctaa agcggtttga 91200 taacacgaag tcgtgaaccc aatttctaga tcttcacacc acacgatgta cttcatgagt 91260 aactccaaga aattttaaca cgatcatggt aagcaatttt atcatgggtt gtggaaacca 91320 taaacccatt agattttaaa actttgatga tcccttcttt aatattttca tcttcaggga 91380 gcttataata aagttcatta tatccgtcca tagctagatt actaatatct ctaaagataa 91440 atgacatggc tctattaatg acactagctt taagttcttc aacagtcata atgcttcctc 91500 acatgtttga ttgatgttgt aaagtatatc atgatatttt tttattgtaa acacaaatta 91560 tttttatttt tcttcaaaaa acagtttaca tatgctttca acatgatatt atagacatat 91620 caaaacacac aaacataaat ggagtatata atgactaaat cacaaattaa ccaaatttta 91680 aaaactttag gttacggtaa tttaaaatat gctaacggca aatcagtcaa aaatggtaca 91740 tcatttgtta aaggtataga acttcattca acaggtccaa tgaatatctc tgaaccacaa 91800 tatgctaaaa tggataactt aataaaagat ttatcatctc attttaacaa agaatattat 91860 cacaacagcc aaatagcagt ttttactact catgattcta aattaaaaat tattgtctca 91920 atgagagaat ttaacaccta tggatatgat agatatgctg attctggata tttaacacac 91980 tatgcttcaa tagttataga gaaaaactaa acaaaaatgg gaccgtaagg tcccattttt 92040 tatattaatc gggttatagc ccctatacct ccaccggccc cacctaatct tgttaaattt 92100 cttaatgaag aacttaaaga attttcttca gatatattat caatggctcc aacggtttta 92160 gattctagcc aatctaatgc ggcttgtcgt cctaccgacc caacttgcat tgatctatat 92220 gcaaatgtaa catcaaatac tgctatagta ttattgtctt catatgataa ttcaggtgca 92280 ctgacagaaa ctgggacaca tcctgtgaac attgcaacag tgtgtggtaa cccgcttcta 92340 ttatgcagat taacttgtat atcagcttct acatcgatag gtagggccct taatcctgtt 92400 attgggtctt caacagcatt aacccaatct tgcatagcac gataattact tgcttctgag 92460 tccattctaa atgatattat taaagggtcg tattctctag ataatatttt tatattagga 92520 gaattatggt ttttatccat ttcataagat aatctatttt ccggtaattt agcagaataa 92580 accattaatc cggaagttgg gaaagccata ttaaaaaaat ctagtaaata tgtacctact 92640 tcaaattcac ctaataatga ttgaacaaca cggtttgtca tggcacctaa aagatattta 92700 gatacacctg atttcctcac taatttttgg gtcccagaaa ctataagact agaaacagca 92760 cttgtcacgt caccttgggt tattcctaaa aaatccgtat ctattggcaa gttattaaac 92820 aaaaatccgc caaaattatc taacagctca tttgtttttg aagatggggc tgttgcaaaa 92880 acaacactaa acatattagt tcgttgaaaa tccaaattca cagcttgact tttaaattct 92940 tctaatgtat acattataat aatccttctg caaataatgt tccacgattt aatgttaata 93000 tttctctaaa tgttatttcg agagtaaagg tgcttggtaa atttggggcc attgctagac 93060 cattaaaatg accattagga gatttatcaa atcttatact tgatatttgt gctggaccaa 93120 atatgtcagt tcttccatca taagaagagg ttttaccgaa atttcgtata acccatattg 93180 ttggattact tacaaccaag acattagata aaaaacttgt tatattttct aatattgttc 93240 cagaagtatc ggccccagtt ggagtattag gatttattaa tgtagtttta taccattcat 93300 caatagctgc tttaatttct ttagcaaatt tagatacacc cgtttcccca taagaaaaat 93360 aactaaatat ttcatatata taaagtattt gaattaggtc ttggggtgtt cttggggtta 93420 gt; tataaatttg ttcaccttta tcagccataa ttccttgtgt tatagaatcc aatgctccaa 93540 aaacggctgt agaagccaca ttacttaaag ccccggttac agaaccgcca cctttggtca 93600 ataatgaatc accaacatca ttaaatctat gagaaatatt atctacgtca gattggcttc 93660 taggcattaa tatatttgca acagattctt gcttaaatgt tgtagttccg cctttactag 93720 aaaaatctat attaatagca tcaacggtac tttgtttttt tctaaaatct cttaaagatc 93780 cagtatctct ggcattataa ttatatgcag taaataataa gccattttta tataagtcat 93840 ttaatctaaa atctaaatca ttatctgttc ctgaagctcg ttctgccgga aattgtgcaa 93900 ctaaagtttt tgtcgggcta gttgtgggat tagaagcccc ggccgatact ttagttccta 93960 tattttcaac agattcttct aaaattttta gtttcattaa ttaacctcta gtgctttata 94020 catgccagga gcagcatatc ctgttacagg agtttgttga ataacagttt tattatttgc 94080 aacattattt tggaccttag cagtgtttgt tgtagattgg atagtagatt ctgatgtttg 94140 aatattatta atattttcag cactagtata atcttgggat tctttagggt cttcaggctt 94200 aatattaggg atttgttcta acaataagtc agatttatct aaggcctcta ttccaagttt 94260 ataataatcc gaatcaactt ctacactttg attatctata attgagcttg ctaattctct 94320 aagttcccta gctattttag acaaattttc cgggttattt ctttgagctt cagccatagc 94380 tataagatta tttaatcttg cttctgtctt tacttgttct tctatattac tatcttcagg 94440 attgttttga ttagtttctt taattgcagt atcagcctgt tcttgggtta taattccacc 94500 ttcaacaaat ttggccgctt cttcttcaac tgtagttcca aacattctag ctttggcttt 94560 aacaactctt gtccatccag aatcttcttc ttgggatgta tttctaacat catttccacg 94620 aactttggcc attaatttta attcatcatc tgttggcata tacccagtat ttttattata 94680 agcctctatc gcggcaactt ctaattcatc ggcccaagta tcttgtccca tagctcgaag 94740 taaagacgat aataatttac ctaatgcaaa ttgtatacct tgtaataaat tttctaaaac 94800 atttacaagg cctttaacta ttgctaatgc taaattacca aaatcacctt ctttccagaa 94860 ttttttgaca tcttctaatg ttgcaaaaat cgatcttaat attggcgcta atggcccaag 94920 tttttcttca aaatcatcaa aagcttcatt aaacaattta ccccagtatt taaaatggat 94980 cattatcaaa tccattgcta atacaacagc taacattata gcggcccatt tagcagcaaa 95040 taaagcagca cttactgtat atttaaataa catatctgct attctatttg tcataccata 95100 cgcagattta aacccagttt tgacattttt attcaaagtc ccaagaattt tacttaaaga 95160 atctttttct ttattgtcct ttttgggttc tttctttttc ttttcttctt caggtttagg 95220 tattctatca atatcttctt tattaataat taaatcttta atagcagact ctagcttaga 95280 atcttcaacc gggaccggaa gtttagaaaa tgcttcttct gtttcagata cttcaggctc 95340 tataacttct tgtttttctg gtttaaattt ctcttttaat aaattactta atttagagat 95400 attagaagaa aatgtatctg ataatttaga tgttgaagac gataaatcct ttaaactgtt 95460 attagtttct tggctagaat ctattaataa ttcaacacca gcttggacat cttggacaga 95520 agaatttatt ttagtcgagg tactttctat tgtctctgct acaagttcaa taccactaga 95580 taaatctgtc aaagaatcag agacagaccc cattgaattg gcaacatttt cttgtccttt 95640 ggcctcttta gatattttgt ttttttcttc tataacttta gttcttctaa atgaatcagg 95700 tgttttcatt ttggaataat cctaatatat catcgccata cacaacttta tcatctaaat 95760 ttatagcgat actttttccg agttcatcgg cccatttata aacaaaagcc ggcatactac 95820 caaaatctac cttttctaaa gataatgttt ctaataattc tttagcagtt gaaaattttt 95880 ctcctggtaa tatgtctcta aatttatatt cttttccttg atacgtaaat ttaggtgttg 95940 gtaaaatgta aacatcatta atagaatata ttttattgtt atactcaaat gtgtcgttgc 96000 attta tcttatcaac cgagtctaaa acaattttta atgtttcttc aggagattta gcttctttaa 96120 atttttcata atagttaagg cctaatttag gaataactaa ttcttttcca tttatattaa 96180 tcttcttcaa cggaagaatt atctttaatt tcatttttta ccttaatatg atctacaggt 96240 ttaagaactt tactattact aaacatgtat atgtgagtaa aactttggtt attagacatt 96300 tcatgtataa cagaatccac ataaaatgta cttaaaaatt ggtttttagg gtcataaaat 96360 tccaatttag tcccaggtgt tatatcaaaa tcaccataag ttgtgcattt agcataagaa 96420 tcatattggg ccatggtatt aagcttagtt gcttcttcat acccatttct gaataattgg 96480 tcagaataac caccattgcg agatactaat atagaattct ctccattacc atttactatt 96540 cttgtacaat ttttatcaat catactaaat gaatatattg tagaattctc gtatggattt 96600 ctgttatatg aatttgtttt tgttatccat tcaaaatcat aggctaatgg gtattctaat 96660 tgatcggcaa attgcccgac cattaatggt tctcctacta ccatttcttt aactttagaa 96720 ttaataattt gttggaaatc cgtgatgtgg atcccattaa aatcatccca aaccaaagca 96780 aacatatcag atgcaacaga aataccagta tctctaacat aatccatata ttccttaatt 96840 cctagcaccc atggtactag aggtacgtgt atattggtcc ctgttatcgt aggttttaat 96900 agaggggcat ccgtatataa aacattaatc atttcttcaa tagtttctgt agcgttctta 96960 aagaatactc tactaaattt aagattttta tttttatatg gtggtattaa ttgcattgtg 97020 ataatattat cacctttttg gtctacagaa acagatgaat atttaacagc ataaattcta 97080 gtttttgata tagatgtatt agcatttcct acagaaatct gaagtatttg gtcaccatca 97140 agtttggtat gcatattctt atggtcataa atctgaagca tgccttcatt tgtcccatat 97200 aaatcatctc tgatagttaa tgtagtaaat gttccaccta gttcaataaa tctattttct 97260 aaccaagcat catagttttg gtagagtttt atagatacat taggatatcc cactctttgc 97320 atgttttttg tcctttatat ctttttctat taatgccaat gttatggttc tattcatagg 97380 ggtcattttc tctatatcag ataaagaata tccctgttta accattatat ggtttatttt 97440 ataaaatgta attatctctt cttcagaaag tattatttta aataaatcta aaatatttct 97500 atatgtcatt tcatgagatt cacaacaact aaatttaatt ggaatataaa ttggatatat 97560 atcttttatg atagtttcaa aatcgtctaa tgatataaca gacatgacaa gatttttatt 97620 ttcttggtct aagtcttccc atagatattc actattagca tcttctattt tatatataca 97680 actatcaaat aattgtttta tatcagttgt catgttattt gtaaaatcaa aatatatttt 97740 tatccccgaa gtctcaagaa ctggtctatt aagttttttt aattctaaat ttagaaatgt 97800 ctttttttct ttaccacatt tagggcactt gaatcttata ggtaaaacag ttttacctat 97860 tgatgccgta aaccatataa taaacgcata tggtctatat atttttggca tatcaggaaa 97920 agattcttct aaaagctcat ctaaaatttg ttctgcttcc tctgggtttt tttctatttc 97980 acttctcaca aaaagtaatt gtaaataatc atcattagaa aattgtctta ttctatatgt 98040 tttttcaggc gtaacaattc ttattatgtt catagtgtct cctcttattt atttataaat 98100 acataaaaag gagacactat gtttgaaata acatgcaatg atttaatata taaagccaga 98160 tatttcaccc tggatgaata cgaggcaact cttctcaaaa taactgataa taatattaaa 98220 gaagctataa ctacgctctt aattgattgt gtggattcct acgatacaaa tttacctaaa 98280 cactatgcag aatgtatttt tcttaaacta tgggcccata gtttaggtgg agtgacaaaa 98340 gacttaaatg gtgtttttgt caattttaat tatatagaat ctccagcaga aaaaggcttt 98400 atctataaaa tagaaaattt aagcttaaaa atgaggtatc caaaattatt tgaagattct 98460 gataagctgg aaatggttat taattgtatt gattctgtaa tattagaaaa tgaaacggaa 98520 ataaagatac aagacctttc atcagaagat atagaagctt tatattcgct tttaacaaaa 98580 gattctatta ttgcattaag agatgaattg cttagaccaa aaccatatat tgcttttcca 98640 cttgatggag aaatacataa aatagaaggg tttaaaaact tattagaggt gatagatgag 98700 taaaatgaat gttttatact ctgacttgga ccctaaaatg gaaaaaaggc tgggataaag 98760 atctacataa agttgtagga gatagggctg ttaaaaattc tattcttggg ataattagta 98820 caagaaaagg gtctagacca tttgatccag aatttgggtg taacataaca gatcagttat 98880 ttgaaaatat gagcccatta atagaagata ctatagaacg atctattgtg tctgctataa 98940 aaaattatga accaagggtt caacgtttaa aagtctctgt tactacatta tatgattcta 99000 attctatcat agtggatata attttttcta tagtagataa tccagataca ttagaacaaa 99060 taaaagttca attatctaaa taatttacta tagttattaa tttattactt aatagttata 99120 tagaatatac tatactttta ataaaataat aaactaagga aactattttc tggagcgcag 99180 ctccagattt taataacaca gagttattaa tttattactt aatagttata tagaatatac 99240 tatactttta ataaattagt ttactatggt tattaataat aggctattat tataatttgt 99300 atataatgta tctttatgga ggaattatga atttagaaga attacaaaca atgttatcag 99360 aagacctaaa aatagattcg ttaaaacttc aatatgaagc tgccaataac ccatcattat 99420 atgctaaatg gttaaaaatt tattctgata taaagaaagg aattatttct tatgaggcta 99480 ataagaaaag attactaaaa caacgattag accattatac aggccgtggc gatgaagtat 99540 gtatggattt atatgaaaaa tctgaactaa aaactgttat tgcggctgac ccagaaatat 99600 taaaaaccca aacatctgtt gaatatagaa atcttttatt agattttgca tccaaagctt 99660 tagatgcaat aaaggctcgt gggtttagca ttaaacatat tcttgaatgt agacaattcg 99720 aggcaggtac aaaatgacga gcattgatat cattaaagaa aatttagata tggtattagc 99780 aatggagaat ttgacaacag attctcaaag agacttagct attaatgcaa tgaagaagca 99840 tttaactaat ataaataata ttaagctgat ggctgaaggt attgataaaa gtgggttatt 99900 acctaattat tctttaccac aaataattga agaaataaaa ggatgggcta tgaaccatat 99960 ttgtgtagtt tgtaaaaagc ctattgatga gagtttagtt atctataacg ataataatga 100020 acctgttcat cctgggcctt gttataattt tgctaaagaa caacctgtaa cagaatcagg 100080 tcattcttta aatgaagtag aattattatt gtaaaaataa aagacgaggg ttactcgtct 100140 ttttctgttt ctagatcttc taattctaat cttttacctt ctaatgcatc tctgatagaa 100200 atatcatctg tatctttaat ttttaattct ttaattcgtt tagaataata tttttctaac 100260 tcttctaatc cagccaatgt ttgacattct ctaattttat tcataaaagt ttctacacta 100320 gcttctatta aaatatcttt aaacgatatc ataatttaac ctcttttagc atttttctaa 100380 ttatatgtct agataaacca gtaccttctg aagcttgttt tatagacccg tattctttgc 100440 catttatgat acatattttt gcggcaggat ttttactagg atctttgtat cgttcttttg 100500 ctgcattaga tatttttatt ctagcttctt tagaatgggt tttaccaaac ataccgttgc 100560 cttggccaga attcctttta gaaatttcaa gcttctcttc atttgttaac tttctaggaa 100620 acttgcgttt tgtttctaat attttgtcaa cccaagtaat ttttctacct gtatataaaa 100680 ggcgcaactt ggatttaaat tcttcagtgt gggtctttcc gtaaaatgga ttaccagttc 100740 ctgattggag ttctgacatt ttacgtcttg cataagcata tgatttatta taatgtcttt 100800 tatgagtgtg ggattgcatt cccatagata ttaaagccat tataatttta taattgtctg 100860 ggtaaatttt agttaacaac ttatgggcta gaaaatgctc ttctgcttta agcaaaacca 100920 aattatcaca tctatcacta ccgcctaaac accttggtac tatatgatgc ttttctgtat 100980 aataatctaa ctttgatttg ttgaggcctc ttttaaggcc tctagatatt aaatcgtcat 101040 atattttttg ataattcaca atttaacctc ttttatgata taatcaaatt gttcctctgc 101100 atagcgttgg atcctttcta gaccatggcg caaagcgtaa tttatatggg tatatttctt 101160 tttagcattt tctgatttag gttttacacc catgtcgtca attatgtcga ataattttgc 101220 tactgttttt gaatcatgct ttctaagaac acgacctata ctttggagaa ctgttacttt 101280 ggatttaata ggatgtgcaa atataacatg gtgtaaattc ttaatagaga caccagcact 101340 aaaaacacca taagaagcta ctacgaccat ccctgagcgt ttttctgcca tagcctttat 101400 aatatctcta tctttatctt taacctctcc tgcgataaag aagacattct cttcaccatg 101460 gatagattta caatattcgt aaagatcttt accgtgtgcg attctatcaa acatcacaaa 101520 aacattttca tctttggacc caagtttaca agctaactta gcaatccatt cattacgttg 101580 ttttgctttg ataattattt ttatttcatc ttgatatgca aaacctttaa ctttttctgt 101640 aaaagcatca ggatatctta aaaataaagt attgatttta agcttagaga cttgtcctgc 101700 ttccattaat tctgctgtag atactggacg atagatgttt ccaaataatc caatatattg 101760 cataacatta gctttaccgt cttttactgt accggttagt ccaaatttaa atttacaatt 101820 acttaagcca ttgataatag tactaatgct cttcccggta gctagatggc aattatgtgc 101880 caatgcacca tttgcaaaat aattgtgatt tgttttaaca tgtaaattat aaactgtttc 101940 aggttttttt atttctttta tactttttaa tcgcattttt cattttccta gcagaatctt 102000 ttaatccatc ataatctata agatgttcat tttctgcaaa atagtcaata tctatatgaa 102060 tgtatttata cccgttagtt ttacaatatt ttttagcttc taatatttta ggatgattct 102120 catcatacag tgatttcggt cttatttcta taacttcttt tgattttgga tcaaagaaat 102180 ccgctatata aatatgggtt ttgttatctt cacctatata tggtattctt attttttcat 102240 atagataatt aggattgata gatgcaaatg aggcttccca gctacttctg taatttttac 102300 cattataaac aacatcaaaa caagtatttc tattattcgt atttggagta aattcgccat 102360 tcagtatttt tcttttcata gtctggcttt gtttttctct ttgctcttta ttatcccaac 102420 catacattcc attattaaca cctgaattag ctttagatat tttggtttta attaattccc 102480 atttatcagg atttgttata gagagatggt gttcatttcc aattttctta cctttattcc 102540 atggagtcct gcctttatta atatctttag gaaaaccacc taagtatttc atttggcatg 102600 atgagattaca atatagatta tttgggttgt ttaaaccttt attacattgt aaacacctag 102660 gctgtgaaat attatgttca aaacactgaa ctaataaatg cattttagga ctacaccatg 102720 gaaacatatt aataagtttt tccatagttc catttttcat catctttctt gttaaaatgc 102780 ggccactagg gccgcgaagt atatttattt ccattctaca atatcatcca attctgttaa 102840 ttcatcagcc cgtacccatc cacaattttc tgttaaaaat ttatgattac ctgtaacttt 102900 aataatagta ttattatcca tttctaattc atacattttt tccgaagaag acttagttaa 102960 atttttatgt aattttacaa cttcatcttc tactatttct ttagtttttt cgttatatga 103020 atatattggg tcaccaggtt ttaaatcttt tattttaatg tcgcctttag gggtttttat 103080 taatgtatca ccatcaaagc actcatcatt cattagcatt ccgaactgtt caaaccattc 103140 tttaggttgt tttatggccg tttgccatgt tgacacataa accaatgcat cagaatcttt 103200 agctgtacca cctttaattc ctagaagcat ttctctagaa aatagtctat agtcaactaa 103260 atcatcaatc atttgtttaa caaggatagt agtaggaact aaaattaaaa ccttaccttg 103320 gaaattctca atataatatc tagccaggag tgcctggatc aacgatttac cagctgatgt 103380 aggtaaattc aacaatgccc tgttttgtgt caggccttta actacagagt ctttttgata 103440 ccaatgaggc gttatcttag tagaaccaga ataaacttct ttagagtcca cccaatcaga 103500 aatttctttt tctgtaattc cgccgttgtc tgttatttta gggtctattt ctactttata 103560 atccatgtta tcagcgaatt ttttaacata gtccactaat ccatatggaa gtaacccatc 103620 atatcctaaa atacgaattt taccgtccca ctgcccatat ttgaatttag gattaaactg 103680 gtaacctggg gtttcaaaag aaaaataatc tctaagttca aagaaaatag aatcttcaca 103740 ttcgattttt acactactat aatcgtaaaa ctttaattta atatccatta ctttcacctt 103800 attataaata catatatatt tatacaaagc ctaaagagga cattatgaaa attgaccaac 103860 aatatattga ttctttaact gaagaatata cttcaggcga aattgataga aaaacagcta 103920 aacaaaaatt atctgaatat gcaaaagaat cgtttaattt tgatttaaac aaacaaaaaa 103980 gtttggaaaa catgattgtc caacttaaag aactgattga caattatgaa gaacccgaat 104040 tagaagatca agacggcatt tccattaaag atctaattac cgcagctgac caattagatg 104100 gtaaaagtgt ttttaatgat gctaatgaag aagctattga tcttatagaa tctatttcga 104160 caccagaaga tcataaacaa tctaaagaaa aaactattgg tctagaaaaa ccggtggttg 104220 aaccagcgaa tgttgaaaca acaaactctg aagtgcagga atcacctgta gaacatccta 104280 caacacaaga acagataact ataaaagaaa attatatcct tccagaagag ttctctccaa 104340 ctattacctt aataggcaaa gctcctggat attacactct cccatggtgg atttataaat 104400 ggattttaga aaatgaagat tggaaatctc gtcctgaaga ctgtcctgaa ttctctgcaa 104460 ttaatatttt aaaatcgtta atttatttta ttaaccgaga tggacaagtt aaaatacgag 104520 aaactagaaa ttctagattt tatacactaa aataaaatgg aaaaaatatg ccaacactaa 104580 atatatctcc tacaaatccg tctataacat taggacagac tcaaaagttt acagcagaaa 104640 tattagaccc aataccagaa tcagttacaa catataaatg gtttgttgat ggtgaacttg 104700 atgatacatc agctacagaa acatttagtt taacacctaa tactattggc gaaaaaacta 104760 taaaagtaga atcaacaagt acaggttcag aagaaccagt agttttgaca gatgaaacaa 104820 ctttgactat taaaaagaaa acaatgaatc ctattgttaa tattgaagtt gataaatcta 104880 ctacagaagt tggaaataca gttaaattta ctgttaaaat tgaagacgtc ccagaaggtt 104940 catcaacaaa atacctatgg gattctggag aaactgaaga atctattaat gttgttacta 105000 cagaagttgg agatcttaaa aaagagtgta ctgttactat atctcatagt gattatgaca 105060 ctaaagaaat taatgtatct tctactgtag atgttacagc taagacaatg gatgacatta 105120 tacttgatat tgttataaca ccagataaag taaaagttga cgaagactac gaagtagaag 105180 ctattgttac gggtggtccg tctgacaaat caatcaaata taaatggaat actgggcagg 105240 aatcatctaa atttacaata acggcaaaag atattggtat aatcaaatat gaatgcacta 105300 ttacagtaaga tgccaaagac tatttatcat ttagcaccaa atcgtcccat tcggttagta 105360 tagaaaaagc cccagaagag ccagaaattg catgccgata cattcatcca ttagaccata 105420 gaaaatctgc atatttgtgg gttgggtatt gggtactaga agaaatagaa aaagccgtgg 105480 aagaaggaat tgattggaaa aaaccaaata atacagattt aaaatataaa tgtaacttac 105540 aaacacttgc tgttatgtta gagacatatc ctaatataga agttcaagaa tcaagaaatg 105600 gatatatttt atctaaagaa gatattgaaa atggagttat ttactaaaca aaaaagggac 105660 catatggtcc ctttttattt ttattttcta aagatcttac caaatttact aatcacaaaa 105720 ttctcaccaa ctttaatatc aattcttatt gaagtatttc caataatatt tgaagacagc 105780 atttcatcta aatctattga agaaattcta tcaaaatctt gaacaatatt aaacccacca 105840 ttatcacaga aggaatcaat aaattcttct attttacatg aacactcatc ggataatata 105900 tctccatata aacgacaagt agacccgtca atattcaaaa taaccataat attctcctat 105960 ttgtttagac atgtagataa taccacatgc ctattttatt gtaaacttaa aattcaccca 106020 tttcttcaat aaattcttca tgatcaaatg ggaacatctt ccaaaattct tcaacctttt 106080 catcagaagt aaattctaca aataatcctt cagagtctgg taaaatttga actatttcca 106140 tttgtaattc tgaaatagct ttgaaatgtt ctgaagttaa agctcttatc caaatatgaa 106200 aagttgtcat ttttatttct cctaatatgt tggtatagtg gtataatatc atattagaag 106260 caaaagtaaa catttaattg ataaattttt caggtatttg gtcaaaatcc attatatcgg 106320 ctaaaataga catggcttca gacgattcaa gtgtttgatt ttctttaata atctcttgtt 106380 ctttaacaaa atttctaaag ttaatttttt caagaacacc ttcatttaag aatttatcac 106440 catcgaaaac gtctgtacat tcaactaagt cttctggtgg catatacaca gtattgataa 106500 gaaaagattt actcaattct cctgacccgt gaatagatct aatttttaaa gctgaaccac 106560 gaggtaatat aacttcagat tcatgagaaa atctagaaag atcccctggg acaataactt 106620 tgactttatg aacacccgag atcataatac caagtctagc aatataatct gatttatact 106680 ctgctttaga atctactact ttatccccta aagtttccct agcttgtgtt tcccagtctt 106740 gtggttgtcc tatataagaa gaagcagaat tagaaaatcc tttattaaaa aatacaggtg 106800 ctaaagacgt cgaaacaaag tttgggaaat acaatatttt attttgaaca cttttatcaa 106860 gatctttgta ttcatggcgc tgggccctat atagaatcgt agatctatct aatttaactc 106920 ctttagaaaa ggctttgtct aaattaggga tatatgtatt aattgtcttt ttagtggctt 106980 catcatttcc taataaaaaa ctattaatat cttcataatt ctgacttgta tagtttgtta 107040 ttgcctcttt ttcttctgct gtatagtcta tggattcttc tagatttcta taagagctac 107100 ctactacatc ggtatatgaa ctagaaatag cttgtataat tttactgata ctagatagtt 107160 tttcagagta ctctatatca gaaggcaaat attttaaagt atactcagta atatctttaa 107220 atttgaaaat aatttcttta tcagatttta aaatttctga aagtttcaac atatatggtt 107280 ttatttttaa atctagttca gatggcgata aatatttatc ttcattatga atagctaaga 107340 caactgctgt tcgtatatta tctaattctg tgtggtattt tgactcaact tgttcatcat 107400 cagacatagg caacatatca gctatattag aaaatgtttc tttagttttt tcattaactc 107460 gtgtttgaat tctggaaaag ggtgcatcta cactactata tataggtgga ttaccttgga 107520 acttaacaaa agcttcttta gcttctttcg aatagccatc taaatcgtct ggtttagaaa 107580 tactatacaa tgcagtcata agctcacgtc tagaaacttt agttttagaa attaaagaac 107640 gttcatttct ttcattttct tgggctgcaa tactaccagc aatggcttcc attttagaaa 107700 cttgcttacc tgttttatca ttaatataaa catcaccgac tttagattct actttagtat 107760 acaacgatga atctatgtca ggaatcccag agatgtcttc taatggttta tttttacggt 107820 atataagaac atatgcgtgt ttaccagtaa attgatagag gtcttctagg actacaaatt 107880 taccacctgt gcgttgcata gccaatcgtt taataatacg ttgtaaagat ttttcttggc 107940 ctttcatttt cttagctggg aatctgaaca atacagatc tatttttaat tttttaactt 108000 gttcataaac agtatcaaaa atagtattca aagccccaat agggtctgct cctaatccat 108060 ttcttaactc agaagcatta ccgtttttag ataaactcat taaaaatact tggacaaatt 108120 tatcgcccat tttaacttgt tttactgcat cccctttaga caaataagaa accatacgaa 108180 ccaaaagatt atcattacct gggactttta tgttccaaag ctgtggaact ttcgcttttt 108240 gattaacatt aatagcttgg tattgagcta tttctgaatc aaaaacttca tttaagttaa 108300 tttcatttaa ttccatttta tcacctttat aataagaata tactattatt tatagcaaaa 108360 aagggcctaa gcccttattt ttatgtattc cttttattca gatattcttg cttctaaatt 108420 taacgtatca atttcaacat caaattctaa aacttctgga ttttcatcag aagatatagc 108480 cattttgtat ttttctatcc cattttttga tgataataaa gtagatttga ctacattaag 108540 ttcttctaca tattcaaaat caccgtaaat attaccatca gtttttgaag cttttttgaa 108600 catttttaat aactcatcat ttgaatattt cattttaatc tccgtttgtt ttgatgagtc 108660 tatagtatca aacttaaaag caaaagtaaa caaaaaaagg gacaaaagtc cctaaataat 108720 tttttgaagc tctaaagaaa tattttttag tttttctacg tcggtttttg taagattaga 108780 tttcttatca agattaaaag aaaccaatgc gttattccaa atagtttctt ctaacaaatc 108840 taagttatcg tttaaaatat tcttctggtg attgtccgaa gatttcataa aaatcattag 108900 cctcttgttt atcaagacgt cgcattttta cacggggtaa aaataaacta taagtttctc 108960 gtccttctac cttttgggct gcattacata caccagaaat aatcatgccg ataagtttgc 109020 cctgtttatg taaatcccat aaaagccgac ggtctaattc atgacgttct tctaatggaa 109080 tccagacttt tttaccttta actttttcgt aatctttatc tttaaaccca gaaccacaat 109140 caactaaaat agttccgtct ctagatttta aattaacacc accaagtttt tctgggtctt 109200 tagaatgtgg ataagcccca ataatttcta ggtcaaaatc tttttcttct ttaaatttga 109260 cctggtcaca agtacgccca tcggcccaaa taccattttt attttttaaa ataatacctt 109320 ctaacttcat atctacatat ttcctgtaaa taatctgtgc ctcttctaaa gttttaactt 109380 cttctgaagg gattaattca aggcgttctg aatttaaggt aattttttct aagtctttta 109440 aacgggcttc ataaggttta ttgatttcat ttttatttga agacgttcct tgtgtaactt 109500 cataattgat taaatcccat acttggaatc gtacacaatc tgcttcgtct ttagtaattg 109560 ttccttggat agatttatta gcaattccgt tgccttcttc ccgagatgca acaatatttt 109620 cttcttcctc ttcatcaaaa aacatatcaa gaccctgttt tttagattta gggaaatata 109680 ctaattcacc atccacaacg acattaccaa gtccttcggt aatttttaat atttcttctt 109740 ttaatgaatc caatccttga tattcgctac ctgaacgaga atataaatta acttcaccat 109800 ctacaacttc agcaaaacat ctagccccat ctgcttttaa ttgggctata gccgggaatt 109860 taattttaga tacatttgct ttactaaatg gcgctgctaa aaattgcggc tgtttaggta 109920 aaagattttc ccatacttta ttaggaatac ttctgcctac accacattct aaatcacgtt 109980 taataatacg tttaactaaa gctgcatctt ttggacataa actttctagt acttctttta 110040 acccggcaat acctgcatgt cctgttaaaa ctctggctcc taatacattt tctaaaaaat 110100 ctaatgcatc ttgtaaagtt ttagattcat ctttaggttc atattccgga atctttttaa 110160 tatggaattt gaccttttga gaatacgtta atctaaatac atctttaaca agatgatttt 110220 gtttatattt taaaagaata gcttcttttt cttttaatga atctgtagaa gccaattcaa 110280 caataatatc gtataccata cctttttcca tttatagtcc ttattttata ctatttaatg 110340 attcttctaa gtcaggtaaa attgtttcaa agtcatacca atctttaaca ttgataatag 110400 gacaatctgg taaatcacgc ttaccacgag gcatatggat aagaggtaat ctagaaataa 110460 ctttatggca atcttctaga ttgtgagcca aatcatcaac aaaacataac agatttttag 110520 tatgttttac tttaacatct aaataatggg gcgttttgga ttcaccgtaa ttaactaata 110580 aaatatcgct aaatgcattt gggaataaag aattcaagtt atataaacga ttaaataatg 110640 cttggtctgt tgaacctaat gccgtaatag ctacaaattc atatttgtct ttaagacgat 110700 taattacttc aattgcatca gtgtagccgg ttaaaaattt aatgtatttc gagttattat 110760 attctgtcat taattttaag ccaagttctt cgttacaacg aaacatttgt cctggcgaca 110820 taaatacatt ttcagtaata actttaagga tatttgttgt atcgatacca taatcttgag 110880 caaaataagg aagtccagat gcccactgga ccaagatacc atcaacgtca gttaaaataa 110940 caggttttaa attcatttca catcctcata ataaacactg acagaagcat ttgcagtata 111000 ctcaaagatt ttaacaattc tttgattatt atcgcttaag aattttttaa tttttgtatc 111060 aagttctttt ttaatcaatg gacccacaat tgttttagct tctccttcga taaatacagc 111120 tattagctct ttattttcta cttcttcttt atatgatgat atattttcta tttcttcaaa 111180 aaattcatat tcatcacttg tcaaaataat agataaatcc ttttctatgt cttcaccatt 111240 ataaatttta ttattaaaga atatactagt tacagacccg tcaccttcta tagaatctat 111300 tttaaacggg tttgtaccaa taaattcggc aatagctgca ttatacatag attcccttga 111360 aaacatttca ggtttatcta acttgtacca tttatttagc tcaaacataa tatttcctta 111420 gttataaact acgcccatag aagccacttt agaaagaaca taaatttcta cttttccttt 111480 agggttgtta gataaaaaat cctcaacaca ctcatctact ttatgtttag cagttataag 111540 tgggaatgac ttaactccat ctaaaatttg gaccagtact acacaatcgt cttcatcttt 111600 atcatcagaa gtttttttaa cttcttcaaa aaaccaggct tcgttttttg aaaaaacgat 111660 atctaaccca gaagaaatgt cagatgcaat taattcgcgg ccattgacta aaattttact 111720 tacatttttt gtatcaggta aaaattctaa caccttaaac acatgtcctt caatgatatt 111780 atatattttc tcgttataca ttgattcatc aaaaaactca cttctagaac cgacaaattt 111840 ataccattta tttaactcaa acatattatt ttcctattgt cagtttaact ttataatctt 111900 aagttatttt aattaactac tctttttctc aaagccatta gtataccaca gaattcttta 111960 tttgttaata tagtttcaaa tatgttttca ctacctatac tatgaactag tttcttattg 112020 cctgtgtacg ccagggcatc cctgaaagat ttattctggt taaacatatg aatatatgcc 112080 ttaatcaata aacgtttgta ggcttcgctg tgtctattaa tgggtgttcc tttataccac 112140 attgtgttgt ttttaatttt tggacctgct agtttagctt ctaatccatg tagtttaaaa 112200 acacgtttct gttctatagg gtcttggatt tttagacctt gtaaaaaacc ttctatactg 112260 gcaaattcct gattatccat tataaaagga tggtatgtaa aattgcttaa ttcattagac 112320 attagagggc caagaccctc tagaatgaat atcaacaacc tgagaactca tatgctttaa 112380 cctcgttaca acaagatacg cgtttataaa tgacccaatc agttgggtca tattttccta 112440 aaactacttt ttttgcttca tctaaagaaa gtccatctaa atctaattcc atacgtgatg 112500 gattaaaaac agcataaatg tcttctgatt cttgttgatc ttgttttttc tgtggttttt 112560 ctaacagatt tctttcttca tctgaagaaa agaaaatatc aaaaccttta ggattttttt 112620 cctctgggat aatatcatct acagaatata atttcataac accttgacta gtgataatcc 112680 ctaagatatc attactatca tttaaccaaa aattaggaaa tcctaatttt tctaaaaact 112740 caattaaaca tatgttaaaa ctatacgtat attggttatt gcttaaaaca gatgtttttg 112800 tgatttcagg gtgttttaat ttatactcag tcatagtttt catagtatat cctttaaatt 112860 aaatcagttt taattatact acactaattt ttagtacttg taaacactta ttttcaataa 112920 aaacaaaaaa ggagaccgaa gtctccttaa atttatttta ttcatagcga cactaagtct 112980 aagatacgct tcatttgact aataattgct ttaccagaat cattatcata aacaaatttt 113040 gttaatgcta tatctcttat agtagttgtt tttgctaatt ctttaagatc gttgttaaag 113100 aaataaagtg catcagcttc attgtcgaaa tacttattat aaaccttttt ttctttaaca 113160 attctatata ctaaattata tacagttgat gttgacattt tatacctccg ttattaattg 113220 tgatctataa tatccttttt taaaagagaa gtaaacactt attttcaata aaaacaaaaa 113280 aaggagaccg aagtctcctt aaatttattt cttgttacca aggttagcta aaaacttagc 113340 tcggccattt tcttgtcgtt taacaaatcc aaccaattta tctaagtcct ggttaatacg 113400 tttatttgtt tttcgtttgt aacctttacg tgcagacata ataattcctt atttcaatgt 113460 aacaatataa tgacgaacag ctttacgggc attggaactt aaatgcttag catattttaa 113520 attatcattt tctaaaagct cttgatgaag agatttttga gccggattta aatgtttaaa 113580 accttcaaga acttttagtg cttcggccag aacatcaatt gatgctccat aattttcatg 113640 gccattttga aaagaattac gttggatatc taaaattgtt tttacaaaag tcataagtgc 113700 ctcaaaaatg cgaggttaat atttagtggt caaattgacc accgtttaga acattagttc 113760 atatacttat ttataaaccg ctgcgattga cctataatgg gccgtaataa atttttggtc 113820 taattctttg gcttttttat tattaaaaac cgtttctggg tgagggacat tacgcatatt 113880 accatttggt aaaggcacaa cgtcaccaat ttcaaaataa cctttaggaa cactatcgcc 113940 gatagaataa atttcaccca attgtgggat ttctccttcg gcccgttgag ttgaaataat 114000 aataccacta gaagatcgtt cttctgttcc tgcagattta gcaattgccg tgataacaac 114060 ggattcgcca agagctttaa tatctttcat taaaccaacc ttaaaatttc ttcatacaac 114120 atagaattaa cagaaataat attttcagta ataatagaac gccatgcatt aatttcggta 114180 tcaaatacac gaatataact tggagtttta gtttcttttt ctgttaacag ttttgaatca 114240 tcttgtttag gatgatattc tgtaggaata atatcataat ctaacgtaca gcgaataaca 114300 cgaactgaat tatctttttt cttaaaaacg atttcgtttt taccattatg taataacgta 114360 cgaattaacg catttaattt agtttttctt tcttctgtaa gtttcatttt acaccacaat 114420 agttagttat agtagaccaa tcaatatgat taagattaga acgttcgtat ttaataactt 114480 caatgcctga atctaataga attttgtccc aaccaggaac atttcggtca tatgtttctg 114540 catacacgag ttttttaata cctgattggg caattgcttt agcacagtca gggcaagggg 114600 ataatgtcac atacatagtc ccgccatcaa tagaaatacc atttcgagca gcaaaaataa 114660 tagcatttaa ttctgcatgg atttcatgtt tagaagacca atcattatga tgttcacgga 114720 attccatatt taacccggtt atagattttg gtctagaacc accattaata attaaaggct 114780 tagtccaacc ctggtcatgt gcatggtcac aacagttaat accacccgta ggagaaccgt 114840 tatatccagt ggaaatgatt cttccaccct tttcaattac cgcacctact ttccaagata 114900 cacatttaga ttcttgagaa ataatatatg ctaattgtaa atacgtggaa gctttcatta 114960 atattttcct gtatattcta ataattttga tggtgtttga acaacgactt caaacataca 115020 aatagttgga ttaaattcaa ctgaaaccat atatctggtt ttatattccg ggtccattaa 115080 cccaattaaa tcccaaatat tatcttttaa atcaattcta taccatggag aagcaacttc 115140 aaacatatta tttatatgcc actgctcaat atataatctt agcatttcat ctagattttc 115200 tggtgaagta tgatttaaat gttttttaac ttcaaatttc attaatgttt tcctactaag 115260 ttaaaataaa ctaaatatat tgtattacga gtttttacaa gagcagattt atcattaatc 115320 atttcaaaac ttttaatagt agaagttgtg acataagaac cattataaaa tcttttcttt 115380 ttgtcgtcac taatatatcc tgataatgaa aaactaccat ttacagattg atttaaaaat 115440 tctttaattt cgtctacagt ttcaaaagta tatacaacat ctaaaactgc atcatattga 115500 atatctttat taatcattat aattccataa ttaaatttgt tgtgtctaat ataccaatac 115560 atgggtctgt aatagatacg ccccataaaa gattttttga tatcttttga ttaccttctt 115620 ctaaattgct ttcaatcata aggccaaaag tatttttaga cttaattgct tctttagcaa 115680 cttcaatttg ctttttaaaa tcaccttcac aattagaatg tgaacaatcg accattacag 115740 gaatatctaa actgtcaata tattctttag aataatttgt tttgtattct ttaccaattt 115800 tgccaccacg taagataaca tgagtgtttt gattaccatt ggcataaatt ttactaatta 115860 caccattcat atcaatacct aaatatgaat gtggaaatgc tgcgctttta atagcatcta 115920 aagccacttg aatatcacct gaagtagaat ttttgaatcc tacagccata ggtaatcctg 115980 aagcaatttc acgatgggtc tgtgattctg tagtacgagc gccaatagcg acccaactaa 116040 aaatacctga tagatactta atagtaaatg ggtctaagac ctctgtcgcc aaaggaagcc 116100 caagattcaa tagttctaaa cagagatggc gggcaattct taacccttca tcaatattaa 116160 aagaaccatt taattctggg tcgttgacta agcctttcca acctacagtt gtgcgtggtt 116220 tttcaaaata aacccgcata accaatagat atttgtcaga cacatgtttt tgcaattctt 116280 taagatattt tccataagta atagcttgac cagggtcatg aatagaacat gggccaacaa 116340 caattaattt tttattaatt ttaccagaaa taatatcttt aattaaatta cgatgacttt 116400 ctacttgtct agataattca ggagaaatag gtaggtcata atgtaattct tgtggggtac 116460 taatagtttt aacgtgcatg gatatcatat tcctctgaat ggattagatg agtatcatct 116520 tcatccttta cccataattt taaactaaaa atcccttgtt tgcacttaac ttcccaaaga 116580 acatcagatt taaataaggt tttaaaaata cgagtaactt gatagataat agcttcatcc 116640 gtataagcat aatcagaaca catagaaata acaccttgtg ctaaatcaga taatgacaat 116700 tgcttaggaa ctttatacat cataacattt tctccaatca acatttccat caggataaag 116760 tccaataata taataatcat tgcctttatt agtttcaatt gtaactaaga cttctttaat 116820 aaacccagaa ttaattgttt gggttgaatt taaatacaca acagaatctt caattttttc 116880 tgaaagggcc tttgccaaag tatggacttt atctttaaac atattctttc ctataatgaa 116940 acaaatactt ttctaatttc gtggccaggc ccatatctat tttctattgc tatttttgct 117000 ttttcatatg ttttatatag gcataaacat tcttctttcc agtgtttaga gaataagcca 117060 ccatggttta ttaatattcc ttgaaaggct aaagtatttt tacgaaaaac cgcataaaat 117120 tccattaaaa ctctccacga ttaattgaaa tttatttcca ttttcgacct ggttgccaat 117180 ctgggtgact aaatctaaaa tcgtttggat ctattgtaga tgcaagtttt ccggatttat 117240 gaatcaacca ttttcttgac ttggcagctt tagaatagtt taatttggct tcatctgtcc 117300 ggatttttcc tttgtttgct ttagatattc tttcacccca ggttttaact tcttcaggtg 117360 aaagaatatc tcgtaagtct ttgccataca taggattatt tttacctgca aaactaattc 117420 cgtttgccaa tctggttttg ttagatttac cagtcccagg aaattttaaa cctttattcc 117480 aaggttgtac accagaatta tatctatttt tttgtgcttt tgaaattttt atttttgttt 117540 cttcttttat cgaattaaca tttaagccag ttttgtttat ataatcccac ccaccagaac 117600 caccaagttt gatattgtat gtatttgggt tttttataa atcttcatta acaatttttg 117660 attctagata aaacgcttct tctggcgaat tgcaaatatg tagaacctct tttataaact 117720 gggccctacc atatttatct atcgcatttg ataatatctt accagaacct aaatactcgt 117780 catttggatt cttggtttta tgaactccaa cataaatctt cgaatttacc aagcaggttg 117840 ttttataaac tgtatacaca tcactcatga gatctcctta taaattataa aactatttat 117900 aaggtcgtct gaggcgattt ctaactaaaa gtttcctgtg ttaacctgcc aacattctaa 117960 tcccaagatt cgccacatat caacaacttg ttgacgatca tctaaaacat aaagaacatt 118020 atacctattt gcaatgtgtt tgtaaaacaa ttctttctta acaatagaat cttttctgtg 118080 atctttatgg ctacgcataa taagcttaga atattttacg ccgtgtttgt taagccattt 118140 ttcggtccct aaacggtgtt cttgttcttc gccttcttca cgtccggaag tcaaaagaac 118200 ctcaacaccc atatcataca tcatatttac gtgattgata acgttttggc ggggtttgtc 118260 tttatatagc ttataaaggt cataagggct tctatgatta ttatcggcaa tagttccatc 118320 gatatcaaca ataattgctt taggcagttc taaagttttc gaccaatcag gaacaccatg 118380 taaataatgt tgcatttttt cataaaatga ataaatcaca gaaggaggaa cagcggcttc 118440 accacgataa aggttacgtt tatataatgt ttctagatct tcgtcgaatg agacataatt 118500 gatttgccaa ttaaacgtag ctgcaaagtc ttcccattta gtccgtgttt ttggatttaa 118560 gtttgtatcg gaaataatga caatgcgatt accaggttga tttagccatt ttagtgcaag 118620 aagttgttgt ttgtctgtga cttgttcttc acgttgtctt gtcggtttgt attcattacg 118680 tttacaatca aaaatttcac aacgtaagtt atctctatta agatctaaaa caacttcagg 118740 attagcatca accatttctt tggcccaggt acttttacca gaaccaggag caccaacagt 118800 cataataact tgtttaacga attcgtcttt aggcttagat ttgtcataac ccaaataatc 118860 taaggtcttt tggtcttcaa tattaaccca aataatctca ttgctttgtt ctggtacaaa 118920 cataataaat ccttatttaa tcaaggttgc cataaatgtt aaaaattgtc cacgaacaga 118980 atcctggtca cgagatattt gtgcattctg ggtaggacta taatcagatt ctgattcagt 119040 tcttaaacaa tatcctagag tttcatattc tctaaaaagc ttatataatg tgtcatattg 119100 ttttgggtc attttatgtc cttttcaata gtttcgatag ttaaataaac tttggattta 119160 attggcgtaa ctgttttacc ggccttttta aataattttg ttgcttggtc cgggtctgtt 119220 ttatatagat tcttggcttc ttctttaatt aaagtagctt cttctacggc agacataagc 119280 tctttaattt gacgacgaag aacttcgata tcagaatcag ggttatgagg aacaaagtca 119340 tcttttaaaa ccataaattt accccagtgg gacttttcta ttaaaggatg acataaaacg 119400 atatctttct caatcaattt attatcgtat gaattaatat attgtacaac taccttatca 119460 ataaaaggat cgttaggatt ttctaatata aaaaccggtt tatatttcgg gtctgatcct 119520 ttagaagaat taaattttaa gtattgtttt aattctgtat cacgaattcc ttcaatataa 119580 gaagcatcat ttactacata ctctggtaaa atttcagcac caatgtatcc aatatctaca 119640 cttatgtggt ttcgtgacaa tgatgctaaa ggtgtattaa accctgtcat accaacaaat 119700 tcagaatatt caatcattat cgaaccatct tcaagagtgg cattaacaat aacagggaaa 119760 tctaaatttt taatagaacg atatccacaa ctgtttaata atttaacttt catttaattt 119820 ctcacatttg ggttcattta actcaacacg ataataacat accatagttt tcatttgttg 119880 taaatatctt tttacgtctt caagccaaat tcttaagtct tgagattctt tataagataa 119940 agcaacttgt ggaccttctt gattaatcac tttccaattg acatctattg gagataccgg 120000 agcaggccat tgtggatgaa tttttggtac ttcaggactc acaggaacaa cgctagcgca 120060 tccggttaat aacataatag gaattatcaa ctttttcatt gtgtttcctc tactacacta 120120 tctgtgaact ttttaaatga atcatttata agtttagata ctaaaccggg cttggcttct 120180 acaacatgtt ctctagaagc atccttcttt aacttataag aaatagtatt tgtttctgat 120240 tggatagaag caaatttctc gtttaaagta ttatactgtt ttatttgaga atctaatttt 120300 tctttatatt gattaaaaga gctttctaat tctgtaagct ttttttctgt ttggtctaac 120360 ttgacagaat tagtagaata taaatggtaa aaaataccat tacttattac caggacaaaa 120420 atcccagtaa tcatgtataa ttttgtattc atcgacataa cttaaaaata gtgttaatga 120480 tatcatcaga agataaccct ctgaatagaa tatgatttct tgatgttgaa gagctacaac 120540 taaaagaggg tatttcagaa gccatatcat cataggtcat atttttatgc ataataccta 120600 attggtgttt ttcataaata gggtctacga taatataaca tttatgcccg ttgatatgga 120660 cattaggctg ggaaatatta ataaaaattt ctgcacctgt atttgctaga taactttcta 120720 aaaatgattt catttcttgg acagcttctg gcattttttc acgtctttct tcagaaatac 120780 ggtcattata ttctttctgt ttagaccgtt tagaagcctt acgtgatata gcagttctta 120840 aatctgaaag atatccaact tttttagaac ctttgtaaac ccagataccg tcatgacgat 120900 caccaaaagc tgctactaca gtttcgtttg taatttgttg taaatccatg ttgacctctc 120960 atttttaatt tttaaatact ataatataaa aacgagaggg tgtaaactac tttttataat 121020 tttctgggac aaaataactg taatatttga caaaaaggct atttaatatt gaaaacaata 121080 catcataatc aaatccgtta tacattttca tgtaagcaga aaatacttgt ggtataccaa 121140 gtttattaaa ttctgcttgt ccattgacag catagtcttt tctgtcttta ccaagatttt 121200 gttcataaac ttgtttaata ttttctactt gagaatgaat agccttagta tagacttctt 121260 caaaagtatt aattttatct aaagccactt ggtcattagc aaataatgat tttagatcat 121320 ctgaagtacc ttctacaatt gctttaaaaa gatcttcatt tgatgtaata gaatcttttg 121380 ttctatgtaa agaaacatag gcatggcttt ttactttaaa tttagtccca tctgacatct 121440 gtgcaactac accttcaatg ccttgtgatt cgtaaacttt gtctacccat ccttcttcag 121500 gttcatatct agtaacaaga ataggtttta gttctttgat agaatttaaa tcgttataat 121560 caatatattc acctgtttca ttatgacgtg cgtttaataa aattaaagcc ggttcagaat 121620 aagaaagaac aatgcgattt gttggagcaa catattcaaa attgaaagta taatcaggat 121680 tatccttaat tacttttctt acatcgctat atgtttctgt attaatcaat ttacaagctt 121740 cctgggcttg ttctgatgtc acggaccctt tagattttaa ataaacaaat ccatctacaa 121800 tataagaact aattaaagac ccatctgctt tatccataag atattctacc ttagaaaggt 121860 ctaaattcat tgtcattggg ttttcattta aattaaaaaa tttctccatt ggtctagaaa 121920 gaattttaat aggatttcct tctgcgtcaa tttcaaacat gataccacga cactctaatg 121980 catcaggtaa aagccaatcg gaatatgatg cgtagttata attaaaaatc cgagctttat 122040 tatttagact taatgacaca tctacataaa aaaacttggt tctatcatac tcgcataaag 122100 ccatcaaatt gtcaaatagt ttcattcttt ttccttatgt tgtgtattcc aatcaggatt 122160 aaacatttta ataaaaattg gctcttcaag gtccatagta cttatttcca tttgccctaa 122220 atcattttta gccactaagt caaaacactg acgataataa aatattacag atttaccttg 122280 atttaaagaa tcatagatat ttttagattt agtggaatct gaagtccaag tttgcctgtt 122340 catggaagtt ctgtaataat ttatcctctt tctaagattt ttggttttac caatgtaaac 122400 taattgccca tcaacttcta tagcgtatat tacatttctt tttgttttaa gctctaatgg 122460 aataggagat atttcattat tatctaaatt aagttctaaa tattttacaa atccgaattg 122520 tttaaatgac atacatataa agggcctaag cccttctcct tataagtatt tcttaaatcc 122580 atctaaaact tctggattaa tatcttcatc aatttgagaa attaaataag aatcgatttc 122640 aacttcttga ggcgctgatt gaacaccttc agaatttaga tatttagaca tccagactaa 122700 aggattttta agacctttat atggactatt taatccagca tgacgcattc ggatatcagt 122760 aatataatct acgtatcctt taagatttgt gtgatttaaa cctgggaccg taccaaattt 122820 aaataaatcg tcaacccaat ctttttcttg ctggtttact tcaagaaata acttagtagc 122880 ttcatctttt aattcttcgg cgattctttt ccaatgttcg ccttctttac cggattgcca 122940 ctgtctaatc atatactggg tacctttaag atgcaattgt tcatcacgag caattaattt 123000 cattatctta gagttacctt ctagaacacc tttattttca aagaaattaa atgtacatgc 123060 aaaagaaaca taaaaacgaa tagcttctaa agcattaatt gcatgcatgc atagataaag 123120 tttacgcatt gcattatcta agtctttttc atatctgctc caagcgccta aaagtggcat 123180 tcctgtaggg tctctttgct cttcttcaga aattaaatct tttatatttt cgtattctct 123240 aattgcctta ataagatcat cataatattt tgtaatggat tctgctcggg ccataattgc 123300 gtcatcaaga acaatctcat caaattcttt tgaagggtct tcataaagat tacgcataat 123360 atgggatatac gaacgagaat gaattgtttc actaaatgac caggtctgaa tccatgtttc 123420 taaagataca tcggaacaaa tagataataa agcctctgaa ggacctctgc cttggattga 123480 atctaataat gtttgatatt ttaaattatt agtaaagatt cttttttcgt gttcaggtaa 123540 tttgtcatat tgtgccttat ctgtcattaa gtttacttct tcaggacgcc aaaaaaagct 123600 taaagttttt tcagtcaagt cttcaaagac ccgatgtttt actgtttcgt aacgtgcaat 123660 acctgtggat tcaccaaaaa acattggttg ttccataata ttgatttggt ttttattaaa 123720 aatgctcatt ttaatcctta attctctttt taaccactgt attatttttt aaagcatttt 123780 cataagcagc tttaatcaat tttaatcttg tagttttata ttctttaata ttatcaaaat 123840 ctatcctggc ggagccagga tattgattat aatttacatg attcgcagtc agagtctttt 123900 gattcatctt ggttatttcc gtcattagta ttatggtaat acattgtttt tccacctaat 123960 gaccagaagt atacatatc atccatgatt acgctcattg gtaccttaga tttttcataa 124020 atacttgggg tgtaataagt attaacagaa atactttggt ctacaaactt ctgcataata 124080 gcagcttgag ttaaataacc tttcattccg cgtttactta ggtcccaggc ataatcataa 124140 agatcttcat taaactcaat attaggaaca acttgattaa acgacccgtc tttagaagct 124200 ttagctgtta cagattttct tggtggctca ataccatttg tgctattaga aacttgagaa 124260 gatgattcac aaggcattaa tgcagataaa gtactgtttc tgataccgta ttgcttaagg 124320 tctttacgta aagattccca atcacataca caaacaggtt taactacttt atcaagattc 124380 ttattatacc aatcaatagg taataagcct tgagaatact tagtttcgtg ataaagttcg 124440 catggacctt tttctttagc taaatcaaca gaagctctga ttaatgcata ttgtagtcgt 124500 tcaaataact catgagtaaa ctgttgtgca ttatcataat ttaagaactg agaagctaaa 124560 gaagcagcat aattagttac accaacacct aatgcacggc gttttttagc aatcaatgct 124620 ttttctacag gataatcttg ataatctaat aaagcatcta atgctctaac agccacacgt 124680 gcaattttat taatttgttc ttggtcttga taatcaaatg aatcaagtac aaatgctgat 124740 agagtacaaa gtgctatttc cccatcatct ttactaatat cactcgtggg cagacagatt 124800 tcggcacaga gattgcttaa tctaatagga gacgtttctc taataaatga accttgtcta 124860 ttaacattat caacaaagaa cggatagatt cttgctgtat tagcacgctc tgttaataaa 124920 atagaaaata cttcagatgc cttgattcgt tttttacgaa tagaagtatc tttttctgcc 124980 gcttcgtata aatcacggaa tttctgttcg ttactaaaat aagcatcata cataccaggg 125040 atttcatgcg gactaaacaa tgtaatataa tcatcattaa ttaatcgttc aatcataagg 125100 tcattaattt gaacaccata atctaaatga cgaatacggt tttcttcaat acctttatta 125160 tttttaagaa ctaacaattt ttctaattca aggtgccaca ttgggtaata taaagtagca 125220 gaaccacctc gaatcccacc ttgggagcat gattttacag aagctaaatg ggttttccaa 125280 aatggaatca caccagtatg gacaacttca ccaaatccaa ttttagaacc ttcagcacga 125340 tacatcccag cattaatacc aataccagct cttttagaaa tgtattttac aatagcagcg 125400 tttgtttcgt taatagaatc taaagagtct ccactatcaa taactacaca agaactaaat 125460 tgtcgtgttg gcgttcttac accagataaa ataggtgttg gcaaagacaa ttgtttatct 125520 gatacaactt catagaattc aattactttt tctaatctgt tttctgtttc ttcttggaat 125580 aaacacatcc caataagcat aaatgcatac tgtggggttt cgtaaataat tcctgttgaa 125640 cggtctttaa ccatatattt agaaataagc tgcatagtac ctgcatatgt aaacttaaaa 125700 tctttgtcat ggtcaatgta tttttctaat tcagaaattt cttgagctgt atatttagaa 125760 agaatttctg ggtcatataa tcctaaattc acattacgag agattaattc aataaatgga 125820 ataggattag attggtcata tactttttta cgtaaagcaa tatgttctaa atttgatgca 125880 acatattgat aatctggtgt ttcttttgtt atattagatg ctgcaacttt gataattgtt 125940 ctctggattt gctctgtggt catgttatca ataaacatgg gcctagcaat ttccatcact 126000 tcatatgggt ccaccgttgt atttctacat gcaatttcta gaacattaat aattttagat 126060 tcgtcaaaat cttgagttac acccgatgat ttaattactt tcatttttat cctttctaat 126120 tataatattg atctattttt ctaatatggt tttgaataaa cgaacttaat atagatgcca 126180 attttataga attttctata ttgtagcata tcataatctt tttatcacac gatgctaaag 126240 aaaacatata aagtagttct ttattttcgg aatttaaata actgacaata gatattgcag 126300 aagaaaaatg tttagtgttt tggtcatctg ataaaaattc ttttatacat atttctgact 126360 tagattcggc atagtctttc caagtatcta aatatttcac aagcttatta agtttagttt 126420 tataatgtgt cagaatttta tctgtattag ttttattagg gcttttaccg tatatataaa 126480 aacttggagt atgcaaaata atatatttag acccaaaatt aaattttata gacgatacta 126540 aatttatagg cctattttta tttcttatct ttttatactc taaagaaatt gtttctgtta 126600 aaacaaccca ttctgattcg ttgatttcat aaaaatcatt attagatatt tctatagaat 126660 tatcagtttt attaacatac ataaaaatct cacaaataaa ttttatcatt aaacacttta 126720 ttaacaactt cggctattat atcaccatgg catggttttg gcgaacaagt gcaaccaagt 126780 cttgtacctc ttaaaacttc gagatgagac ttagttattt gtccagattt tattttgtta 126840 agaaaatatt gcttaaattt ctttatattt tcttctctag tcccatcttt aaaaggatta 126900 ccgaacatag ttccacgttg aatattaata tcaaagtcag aattatattt attaactact 126960 gtacagatca ttccaaaaca accattataa caactacggt gacaattata atcaatacta 127020 acggatccat tatatttcct taaaccaagg ttgagtatct tcatacaaaa atcctgccat 127080 caaacagata acaggaaacc aaataataaa agctaataag tattccatat taatcctttg 127140 ggcccataaa agcttttaat gtttctttaa gttcatcaat cctaatgaat tcattaaatt 127200 tatctttgat atctttagat gaagatatac aatatgtgtt acaatctata tcatgaatat 127260 attcgaattc tacacttgca cctgtatatg caaaaatatg caatgaagac catgcattag 127320 gattaaattc tactatatta tctattagat ctacgtcata aaggtctttt agtttatgca 127380 aatctgaaca aagggattca atagaatccc aaacacctaa aatcttttca ggttcatcat 127440 aataggcttg cactaaaaaa ttcataataa atcctataca ctaaatgggt atttaattgc 127500 agggtgatat tgataatctt gtatctcaaa atcatctacg gtcacccagg tttcaatatc 127560 ttctaaagat tgaatgttat cattaataat aagttttggt gcctcaaatg gctctctaga 127620 gatatgttct gggactaatt taagttggtc ttcataaata tgagcatttg taattttatg 127680 aaatacacgc ccaaatttat taccagtaat ttgtgccatt aagcgtaata aaacgtaaca 127740 ctgtaccata ttaaaattta atcccaatgg gacatcacat gatctttggt atgaagttaa 127800 atataatgtg ctattaacta aagaaaaatt atgagtatgc atacatggac gcaaacatcc 127860 tagatcaaat tcacctgggt tccagaaagt aataatttct ccacggtcat caataccttg 127920 gcttaaatta tcatatactt ttcttagttg gtctacagaa ccattccaag aacgtccttg 127980 gacaccgtaa acacgaccca tatcatcggg tcctttacga ttagggttat ttaaccatga 128040 ttcgttttca tttgcatttg cattccatgt attacaccca atctcacgaa attgtgcagc 128100 acttgaatat ccacgaagat atcctaacag ttcagcaata gcagctttat aaaaactttt 128160 acgtgtagta tcaataggaa attcagaata ttctaggtca gcgttaataa taacacgaca 128220 aaatttacct gttcgtttat tataaacatc ctgaccttca ttataaattt ttttcaataa 128280 tcgttgatac tggtattttt ctaaggtctt ttccatttat tatctcttac ataaacgagt 128340 tgtttaaatg ataatttaag ttggtctaaa tcaacttttg catcaggttc tgcgaattct 128400 aattcaccgg tacctaaaag cttaccatca acccaaagct ctataagtgt gatatccgaa 128460 taattttttc tagagtttaa aaagtttttt acatcttcta aattagtaaa aactcctaca 128520 tttctaccgg attcgcatat attgacatca gtaacaataa gaatcttcaa catttttatc 128580 agccaaaaca aaataaattt gctcaccttg tttaataaaa tatccgtaca tttttagttc 128640 tgttccttga acattaacat atccttcaga aacagcttta gttatgtcaa ataatgtagt 128700 acgaatataa accaagccat ctttagttct aatgcatgta catgatgaat tttggtttga 128760 gccaagttct tttatatcac atgagatttc ataaatacca tgtggtattt ctcgttcttg 128820 gcaatttcta taattagact taaaagccct taaagaaaca gaatctaaaa agaatgttct 128880 tgaaggaggg gctttaacta atttccatga acatattggt tgtacaaact ttttatacaa 128940 tttaatttca gccattattt aaatcctcat ttattaatgg ataaaggcaa ataacacgtc 129000 cgttttttct aaaaattcct tttactgtaa tgtggttatt ttcaatttta gtgtggcctt 129060 gactaataga tttaaatagt cgtgataaac atgtatcaac tttaatacat cttttatctt 129120 taatgtctga tgtttttaaa tataagtcat gcccattacg taaacattct ctatctattt 129180 tccaatcttc taattcataa acaccatgtg gcataacttc cacatattct tttcgtaaga 129240 ggcttttata ctcttcaata gtaaggtctt taaaatataa gaaattggtt tttggtgctt 129300 caacaagtac ccatttaaat ccggtctcta aaggtcgaat taatttcatt tttggtctct 129360 tatcaaatga ttttcttcta tgcagtcatg gcgattaagc atgtaaatat gttgttcgat 129420 tttcttaaaa tttctcagtt tatctaagtc aacaaataca tcactctggt aaatacaaga 129480 ttttttaatt tcagtccaaa taactttatc acaaaaatca aatgaagctt caattaatcg 129540 tttaccacca ataatagata ctaaattttt taattcagga tttcttgtaa acatttcaag 129600 ttctttacaa acttctttaa gtttattaga atcccaaggc ccaataattt ctctatctgc 129660 agatttgcca tctaatgata ataaaggttc tctaggatca tcaaccataa caatagaata 129720 tcgatctttt aatttaggca tagccataaa agtttttggc cccataacaa tatatgaacc 129780 cacatcagtt gcaggattca ctctaggagc aattgttctg gacttaaagt tatccatatc 129840 ttgtttaatt cgatcccaag gaagtccacc cttaagtcct atgccatatc cttttggttc 129900 tttttgggtg gcaaaaattg tctgaatcat aattcacctc attaattttg atatctatag 129960 tatcatgata aaaatctttg taaatatttt ttcactaaaa acaaaaaaag gaacccgtag 130020 gttcctttta agattaaatc agatcattta agatatcatc tacagattgg tcacttgtag 130080 aaacactttc acctaaatca acggaatcat taaatgcatt catttgttta gaaaaatcat 130140 cttgagcaga taaattatct aattcggcat caatatcagc tgaagcacta gaagcagaac 130200 ctgcaaccat acttacaccc ataacttgtt taaacttagt ttcaagttct gcatatggtt 130260 taaactggtc tttagctacg attgtttgta aatctacaca ttgatcaata attgatttct 130320 gtacagcttc atcatcaata ttaggaattt ctgattgagc gtagaattta caatcatcat 130380 aattagggaa accacttact tttttaactt taagagcaaa gttagcacct tcaaaaggac 130440 agaaaatatt aaccggagtt tcgcccattt caatatcaac gttggccatg gcatcaattt 130500 tatccatgat tttttgacca aaccgatatt taaatacttt accttcattt tcaggagaat 130560 tagggtcttt aactactaaa atattagccc aataagaatg tttacgttta atcagtttat 130620 attcttctgg attagtatta tatgagtctt tttctgatag atatttacac actgggcatg 130680 attcataatc cccatgggta gaactacaat tattgatata ccatttaccg tttttcttaa 130740 atccatgatt tgttaattta acaaacggag tagcattatc atctttagct ggtaaaaaac 130800 gaattactgc gttaccatta cctgcggcat cagtttttaa tttccattcg tttttatctt 130860 cagattggaa accacctttt aagccagcta attgttcttg aagttctgtt actgatttac 130920 gtttaaacat atttttacct tactttattt tacagtttta ctttatttac tttaatactt 130980 acatgcattg attgtttcta caaaaacttt ctttgcagtt tcactatcta tttctagaag 131040 ttttttgtat gcatttaatt tagttgaata agtggaccaa actaaatcat tagaacattg 131100 gtcatgttta tttataatac ctaaaaatga atcaagaaga ataaatgttt cataaccaat 131160 aatattggat tggagaagtt tgaatatata agatgtttgg gtcttagtat tatattcaaa 131220 tatctcttta agcgtttgaa catttatttt tttagaaaag taataaatat ttttaaggtc 131280 ttctttatat acttcagaaa gaccttgtaa tttacctaca tattctcgat aaaatactaa 131340 cgcatctgca tctgatattt cacctatcca tgcatcttgg tttgctacta aattagaaat 131400 aaaaatataa acaagttcat taagtttata tttatcagac aacttttcaa aaaaatattt 131460 atcacgacgt ttattataag ccgcatccga tatacgcata acccagttat atttaattac 131520 atcgtattta ccattcatat gattttttaa catcagatat aattggtata cacttttacc 131580 ggtgatatat ttatttgaat tagatggaat acggacttta atcataatat taaaataaaa 131640 aatctaatgt gtttaatgtg aatgttttac gaacagaagg tcttaattca ttgttttcta 131700 aagcttcttt agtgatctta tcaattattg cagctggtaa atatttggta catagattat 131760 atggaataga attttcttct aaccaattag tagaagcttc tatataagaa gctccttctt 131820 taactttttg ctctattaaa gctccaacaa tagttgggtc ttctatatca atattaatgt 131880 tttgggaaca aagagtcata taaatctaat gcctcatcag tttcggcttc aaaacgttca 131940 cgggtttgtt tatgataaat tgcaaaaata cgtgtccaca ttttagaatc tacacctaat 132000 tcatctttag cttgattttt aatatcttta attttttctg catatccttc catgatagtt 132060 ttttggtcag acgcttcttt aatcatagct gctaattttt caccatgtac tgcttcatca 132120 aattcaattt tttctttaga cataattacc tctaaaacat gttaatatct ttagttaatt 132180 taactaatcc agcctttaca aaatatggat aaattttact tcttccaggg actttaaaat 132240 tatcaaattc atctataatt ttttgtttaa tatcctctgg aatacaagtc atatctatca 132300 taatcttatt ttcattaaag cgtttaagtt cttcttctga aaggtgtttt tctggtccat 132360 catctaaaca tgactggatt aatttagtag aaatacttgg ggctctttca ccttcaacac 132420 gagtaaacca ataatcagaa cgacatttaa caccggctac agtatctttt ctatctcctt 132480 taaggagctt tgtcattaag aattctggga tagattcttt tgatttaacc attttcttaa 132540 gttgtggagc ccattgttta atattattat taatatgcaa ttgtttgtag tcaccatccg 132600 aagaaataat cattattttt ctatctaaac attctctaag agtaagaacg ccaataatgt 132660 catcggcttc aactcgtgga atgtcaatag tataataagg catattttct ctgaattctt 132720 ctttaatttg attgatagca gtaaaatatc cttcccaatc aaaagtagaa ttctcatcac 132780 gatctgcggc ccgtgtcttt ttataataat agccgtaatc tcgacgccaa taaccattgt 132840 tagcattatc aaatgcaaga actgtaatag gatattcgtc attaaatttc ttaagattaa 132900 atcgaatact atttaataca atgtgtctta acatcccaat cttaattggt gtattctgga 132960 attcttggaa tgctgcggct aatgctattt gagacatatc aaagaattta attcctggtt 133020 tttcatcttc ttcgtcgtca aaaaatgcac ttaaattaac ttgattcata aaccctctaa 133080 taaatataat aaagaaagga gccatatatg actttaaaca aatcacttaa agcaacatac 133140 ggacttgatg cctctaacga aaaagttata aatgttggac tagccgacaa aaaaacttta 133200 acagatggcg ttaatgtcga atttttaatt caagaaaaca caatccaagc atacgacaaa 133260 aaccgtggat atgaaaaagg ctttgcggtt atatttgaaa atagaattta tgtttcaaat 133320 caaaatatag aatcacctgc aggtgatttt gagcctcata aatggttttc tttacgtgta 133380 gaccctaaat gggaaacaat attcgaaacc gtgtcttcag gacagattat aacatcagga 133440 caatttattg cagctaatac ttcaataaat gacctttatt ttaaattacc tagaaaacca 133500 caaccaggcg atactgtttg tattaaagaa gtttctggta attcaggtta caaatacctt 133560 aaaataggta aaactgataa ttccattatt tggaatggga cagatgttga agaattatat 133620 ctaacaagac cttattcgca aacttatttt atattttctg gtaatgtttg gaatgtattt 133680 caaattgaac acgaagatat tggaagaatt atatctacat cgccaataaa gcagcaggtt 133740 tctgctggtg aaagactgta tagattatct tcaacaggcg aaattaatat tatgttacca 133800 aaatatgcta tgcatggtga tgtaatagaa atgtttgacg ttgacgggtt aacatcaata 133860 aatcatttaa caatttttgt ttcagaaggt tcaggacatg ctattggaac actagggcaa 133920 actaaatacg aagttagaac catcggtaac ggccgtttag tatttgatgg ctctaataat 133980 ttatggagat tatgggatgg tgatattaga acaagattaa aaaccattaa agaagaccat 134040 aaattactc ctaatgagca agttcttgtt tatggggcaa ataatactgt taaagaaacc 134100 atcacattaa ctttaccaag aaatatagca gtgggtgata ctgtagaaat atcattagga 134160 tatatgagaa aaggtcaaac agttgtcatt aaaaccgaag gcggggatat tattgggaca 134220 gataaaaatc ttttacaatt cccaaaacgt tcacaatatc caccagaaat ggcttgggtt 134280 gaagttaaag aactgacatt taatggaacc gatgattatt taccatactt aaaatttgca 134340 tacgtagaaa cattatctaa acttggatgg gcagttcaac attatcgtcc taatgttgaa 134400 agggttgatt ttaaaaatcc agaaagaatt ggattaattg cattggccac tcaaaatcaa 134460 gctaatattg atcatgaaaa taacccggaa aaagaattag ctattacacc atttacactg 134520 gctaacagag ttgccactga agaaagacgt ggtattgcta aaacagcaaa atcttctatg 134580 gtcaatcaaa actcaaatgg aaaatttgaa gatgacacta tagtcacacc taaaaaatta 134640 aacgaacgaa cagctacaga agaacgacgt ggcctggccg aaattgctac tcaagaagaa 134700 acaaataccg gtaaagatga tacgactatt gtttctccgt taaaactcga gaacaggaaa 134760 gcctcagaaa ctttatctgg tattgctaaa atagttccat ccaagggagc cccaggaaca 134820 caacgtgata aaccaggtac aggtgtatat aattatactg ataataccac aatagtttct 134880 ccttctgcga tacacgaact tctaagtaca gaaaattcac atggtgttgt ttacttagca 134940 tctgaaactg aagttattga agcaccagat atggacccta aatttcctgt tgctgtaact 135000 ccggttcaat tacataagaa aactgctacc gaagatagaa ttggtttctc tcaaatcgct 135060 acacaagaag aaactgattt aggacaagat aattttaaat tcataacccc taaaaaatta 135120 aatgatagaa aatcttcaga aacgttagaa ggtatatcaa gatatgctac gtatgaagaa 135180 tttaaaaagg gtgatttaaa tttaatttct gaacctggta aaataaaaca atttttacaa 135240 gaagcaagaa taacaactgt tcctgaatct ggaattgttt ttacaggtaa tatttgggac 135300 acttgtaatt ttgatattaa ggcttcgtct gaagttgata gaggaacttt aaaattatct 135360 acacaagacc aaactgatac aggtgaagat gatacaactg ctattacgcc taaaaaatta 135420 caaaacaaaa aatcaacaga acaagttgaa ggaattatcc aactttcttc ttatgccgaa 135480 acaattgcag gagaaattaa taataaagca atttctccac aaaattttgt tttagctgta 135540 caaacagaag ataatggttt acaagcttca acttctttac gtggttttgt aagattgttg 135600 gatggggcta gtgtatggca aggaactgac gaaacaggta gtgatccaga aaatgaagac 135660 ttcttacatg atggatatgc agtttcacca agagaactaa acaaagcttt aagtcattat 135720 ctccctatta aaggcaaagc cgttaattct aaattatttg acgatttaaa aacttctgat 135780 tttattagaa gaaacattga ccaagaaatt gatgggacca tgacttttaa taaaccggtt 135840 atacttaaag atacgttaat ttctgaaagt tctggcaaat ttgagtcttt agaatcaaaa 135900 acggtttcta ttggcgatgg tactattggt tcaattgatt ttttatctac aactaaatgg 135960 aaaataaatg tccaagatga tttcaaaatc aatggtgtta aaattgataa agatgaagtt 136020 atccattcta aaggattaga aaccgtttct tatattgata cttcagaata tagattaaat 136080 ggtaaaacat ttatttctgg acaaggcact attaatgtag gtgatgctga atctcaaatt 136140 agattccaat ccaaaaatcc taatgatgta agaatttctg gctctacaat tattgttaat 136200 accaatttag aagaaaaagg taataagcac tttattaatc gtaaacaaga taccgttgac 136260 ggagatattg aatttactaa acctgtaaaa attaatatcc cagaaaacat ggttgaagtt 136320 tctgaaggta tatttgttgc taaaattact tctaaagaag aatatgaaaa atatccaggt 136380 atagcagttc ctaaaataga ccaagaaaca cagaaagtta ttgattatac ttatgttaaa 136440 ggacctggta cgttaactca gtatggcgat acaaaatcat acacatacag aatctgggct 136500 cctcaagctt taggacagga agataatcat aataactatt ctttatggat gcaggtttat 136560 aacccagtta aaggtgaatt tgatgcatgg ggtagaatat acacatctca aaatccacct 136620 actgctgcag aaataggagc tgtttcttca tctggttcta ctttcgaaac acttaaagtt 136680 aatcaatggt tacaagttgg acctgtaaga atggttccag acccagtaac taaaactgta 136740 aggtatatat ggatcgatga gtaatataat ggttgaattc ggccaagatt atgtgggtgc 136800 tcaaacgttc tcagagaaca atgctctcac atataagtta actataaggg ccagtaataa 136860 aaacacacag ggtgaatcct gtgtgttaat taatgataaa aaaatatcag atcaatgtca 136920 aaaaggattt aatgtttggg ttatagataa taaaggtaat ttactcaata atatggtctt 136980 cgattttaca gaagaatcgg gaagaaatgc ctttattgat ttcatgaaat cccaagataa 137040 agatataatt tgtattagtt cttctgatga attgttttct tcggaagaac tctcaaaata 137100 tatgaaaagt ataggttctg cttcatggaa tgatttttta attaaaaaga ttaaaactgt 137160 ttcttatgca tgtgtatata gaacagatat aaagcaaata gtactagaat ctatccaata 137220 ttcagatggt ataaaagaag ataatgtttt agaattagaa actatttttg attctgagta 137280 ttctttaggg ataactggat ttcctggttc tatagtctat gatcataaag aatatacatc 137340 agttgaaaaa gactataaaa aatggcctac taatttgttg aataataaat tatccgatta 137400 cggtcttaaa ccaggtgatt gggtttcttt aagtgcatct atattcggtg ataaagagct 137460 taaagacgaa ggtggttgga caaggataga ttgtagatgg gttcttggca atacatggaa 137520 acaatcgttt tatcttgaaa gcacactaaa aggcagttat ccagttcaaa ctatggtaaa 137580 tccggatatt tgggaatcta aaacagttta ttctcaaata ccagaaggtg tagatggctt 137640 tgttattata gcaactagat ataattcaga gactggctat tctgctgtaa aaaatgttgc 137700 atttggaaaa tcagcagaac ctataataga agaatccgat cgacaaatag ggataaatgg 137760 tatcagaaat tcatttataa aagaggaaga acaaaaagta ggttcattat taagtttatt 137820 aaatcttaag gacaaatccg atacaatttc ttctataaac tttaaagaaa tctaataacg 137880 tatagttatt aatttattac ttaatagtta tatagaatat actatacttt taataaaata 137940 gtttactata gttattaatt tattacttaa tagttatata taatataaag aacttaataa 138000 attctgggag cttcgctccc agttttcttt agaaaaggct cttttataaa tacaataaag 138060 aaaggagttt atatggcaga ccttaaaaga ggaagtactg ctggaggaga attaattctt 138120 acacaaggaa attttccatt aataccagtt ggtaattctt tatattttaa tacacataaa 138180 gtctacactg aacatgataa gcctacagca gaagaagttg attctgtttc ggcttctaaa 138240 ggtggagaat ttaaagaaag agtaattttt aaagaaatac aagttaatgg taaaacaact 138300 ccattaacaa ttaaagaagg gttagaaaca gatagcgaaa tatctatagg aacattagat 138360 attaaatcag gtgataaatc tgttttattg attgatcctt ctaatcctga attacttcaa 138420 acagattcta taaaaactaa taaaaccgtt ctaacatccc caggaacaga agccaatcat 138480 gctgttagat atgaccaagt tgtgttggta ggtgatgtta ttgactttgg agaattctaa 138540 tggcaaaaat tccaagaata caatttaaac gaactaaaaa tccaggagta aaaccttcta 138600 aagatatttt agcagaaggt gaattagcta ttaacttagc agatagaatg ctttttacca 138660 aatcaggtga agaaataatc gatcttggtt ttgctaaagg tggtactgtt aatggagata 138720 ttatccaaga aacaggaaat tttacaacta atggaaatat cagattaaaa gaatatctta 138780 acattaacgg cccagataat aaagctttaa atattgcata cgattctaga ggtccactta 138840 ttggagtaaa tgaaggcgat aataaatgga aggtacttca aatcccagct gaaaccggga 138900 catttgcatc tcgagaatgg gttaatactt ttgttaaaag tgggtccatt caaactgact 138960 taaaagcccc agataataca acggttctta ctataaataa ctcaaaatta ttatcattta 139020 aagatgggac cactgatata ttcgctgtag atattaaagg cggatatatg agaaattcat 139080 taatactatc tggacaaaat gattatcctg gtattacgct tcaaaaaaat gatactttta 139140 aagttagaat agaaactgac acagattcta gtaatacttt attggcattt gcttatagag 139200 attctggcaa ttctaataaa tttgttataa aaatgccaaa agaaaatggc gttttagcat 139260 ctcaacaatg ggtagatgga aaatattata aaagagatga ttctcctaca tttaaaggcc 139320 aagtaaatat tggagataaa ggcggtaata gcaattacgc tcaattatca tatgaatctg 139380 gagaagccag atggagtgtt aacaccggtt cttggaaaat actaaagcat cctaatgaga 139440 atggaactgt tgctacgcaa gaacgcataa ataaaatagt taaccataac ggccaacaag 139500 ttgagttgat ctctcctaat ggaactatga aagcaacact tcaaaataat ggcacattta 139560 gtacatggaa tggtaatggt aatccaatat cagttgatgc ttctggtaat actagtgtag 139620 cagggactat tcaagcggta tctacagtta cagcaagaac cgccaatagt aatactattt 139680 ttggtctttt tgttagagat aaagaagcat ttttgtctct aaacatagat aataagtggg 139740 ttggcgaact acaccatcct aagacacatg ggacaattgc cactcaacaa tggtcaaatg 139800 gtcaacatta tactaaatct gaaacctata ataaatcaga aattgatggt aaagttaatg 139860 gtagattaac tcaaagccaa gctgatggaa gatatgtcag aatggatttg actaatctag 139920 gtaaacaata tacgccattg actggtattg catctggaca atggggtaaa cctattggtt 139980 attctgttat ggttaatagt gcatcttcgc ctcagcgccc tccaaataca ggatacggct 140040 attggcatgt aattggggct agagaccaaa gcaatgggta cgccggtata tggggtggat 140100 attctgatgg tcaaatgtat tatggtaatg gtaataccgc agctacaaat cctacatggt 140160 ataaaatata tacttcaggt aacaagcctt caccatccga attgggggtt tatgccaaag 140220 gtgaagttta ttctaaggcc gaatcagatg caagatatcc tttaaaaaat gatgtttacg 140280 ctaaatcatc aacatattct agagcagaag ttgattctcg tgtaaatggt agattaacac 140340 aaagccaagc tgatggaaga tacgcataca aaggtggtgc tactggacaa aactttggtg 140400 ctaatatagt tgatgctgca gatgttaata ttcgttcaga tatctctgtt aaaagtaatt 140460 tagtatatat aaaaaatgca ttagatttat taaaaccgtt aacaggatat aaatacgatt 140520 taagacttaa tgacaatact cataaacagt cggtaggtat aattgcacaa gatgtccaaa 140580 aagttcttcc tgaattagta caaaaagatt cgacagattt attatcagtt aactataatg 140640 ggttaacagc agttcttatt aatgcggtta acgaacttaa taacagactt aaagaattag 140700 aggttaaaaa tggcagtaac aggacctaga gtaggaagtt ctgctaaagc agaaactggt 140760 ctggctagta tgaaggccgc tggggctaaa ttgggactta gcgtcccttt taaaatgtca 140820 caaatgattg gtaaaagcgt agcgggttta attttcgcag ttgacgtaaa tccagattat 140880 ccgggcaata aatacggtaa tttttctact catggaaccc caaaagggta cttaaaaaaa 140940 ggtgatactg gtgacaagct catgcaaata gaaggtattt acgccattaa ctttactact 141000 caacaagtaa tgtttattat gagtgaccct gcaaggattc acaattacac tgctatgatt 141060 attgagtata gtggtacaca atataaattg gtaccacaga gagatgcgtt agggactgct 141120 tatttcaata tggtaacaaa tgttgataag tttactgagt taatgatgaa aaatttaggt 141180 gtagaattcc aaatgaaagt tatacagata acttaatttt tgaaagttta agagaataac 141240 tatggataaa ggcttttttc taagcctgct tgatacactg tttaaagacg ccgacggaaa 141300 attaatcctt tggcgtcttc tttctatagg agtacttggg attggatgtt ttttatatgt 141360 cgctagaaat gaatttttgg aattatataa aaacactaga tacgaggctt atcagcaagt 141420 tcaaaagcaa gaaagagaac ttaaatttga aaaggccgta gtagaccaat tgcaaatagt 141480 ccatgtatcg tcagaagcag agttcagtgg aataactgaa tttagaccag ttggattaaa 141540 ttattttttt gatttaattg cttatgaagg aaaacttcct gaggaattga attctaaaaa 141600 tttaggagga tggcctgttg ataaaacatc agaagaatat attgaacata tgaatggaca 141660 ttattataca acaaccgaac attttagatt gccaacaagg aataaaatag aaaataaatg 141720 gttgttttct tgtccatatt ataatttgaa taataattat gctgggagta tatttatgat 141780 gtggcctgaa aaacctgtta taagcgaaga tagacttaac atcatctgtt cacaggcttc 141840 caggaccata ggcaggacta aataaaatta cgaatataat ctattgtatt gttgtttatg 141900 ttgtgtctga agggattcta cacaacattt acaatatgga aaatacccat ctttagaatt 141960 tttcgattct gaaaattttt ctaagggcaa tatttcttta caatgtttgc atattttacg 142020 taaaggaatt ttaatttctt tcgcaacacg tggtaaaact actaattctg tctttaaata 142080 cgtatttttg caaaatcccc caatctacaa ttgtgtcttc ttcatctaat tcaacgacaa 142140 ctccaatccg attaccagga ttagtgggat ctatattata atactcagaa tctttactga 142200 tatatacaaa atcaccaact ttaatagtca taattaatcc ttatggtgtt tacttgtggc 142260 atgttaaca atcgtatgag tgttaataaa atcaatagct tcttgttctg taactaattt 142320 aatttctaaa gaatcaacgc cattttctaa tcgttcttct aacgggcata aagaatcaac 142380 gtaatctgtg atagatttaa tataattttc ttcagtaacg tccttttttg ttcctgaagc 142440 aaatttatct gcaattacac cattcttttt atatgtagta atagaaaaca ttataatgac 142500 cctttttctt gatttaaatt aattttatac tcaaatacat gagcataata cccgttatga 142560 atattaacaa tttctaaata atacccacca gagatttcaa atgtcatgct attaaaataa 142620 tttgatccat catcttcaat agaaaattct gctacgccaa taaattctgc cgattctgac 142680 aaatctgaca attcgacttc tttaaaccca ttattgaacc tatcattttc ttttttgaag 142740 aatttataat aagcatgttc gcaacaatgt tgtgaatcta catcaaatcc aacaaagtta 142800 tcattattat caataaaatt ggttgttttt ctttcgtatt ttttgccaca caccttttca 142860 ataatcattt aactaattcc aattcatctt tagagaacca atagatatgg ccaaatttat 142920 ctacacatgc atattgtaat ctagaatcat taggctcaat ttcatggata gtaagatctt 142980 cgccaatatc aatatcacat tctacgccaa tggtattttt aacaaatttt acagtatcac 143040 cgacagaaaa cagatcacca agtttccatc catgagactt aaatttagcc acaataccat 143100 tttttaattc cacaataaat ggatattctg catcatctga aaattcttta agtgttccta 143160 caataccatt attacagatc tcatcacccg tattaaattc atacggttca gcccaaacat 143220 cttctctaaa ccacatttca agaccactat cagtttttat ataataagga tgatctgagt 143280 ctttatccat ttttaataca tgcccggtac aatttgggct tacggtatgt ctaactttat 143340 caccgacttt aaatcttaat tcgtcattac gtttaaacat attaacctct atttaaatac 143400 atttcaatta aagaatatgt agatttatga ccggtattaa attcttcaat aagtttagct 143460 ttttcgtcat cagataatga tttaactaat gatttaagat tacttttatt aaataactta 143520 ccattattac gaatacctaa ttcgttaatg aacgctatga aaagattttc atcttcaatt 143580 atatcttcac tttcaaattt gataagaatt gagataacag caaaaatttc agataaagtt 143640 tccaatttgt tcattttgtg ccttgcttgg tgttagtaaa taataattaa aattttgtac 143700 ttctaaagat ggttctacaa catcccatcc tgataatata tccatcattc caggacagta 143760 tattttacta ttacaatata atttagaacc atccaacgta tatacaatgt tccctgttat 143820 tcttgactgt acttgaaatc cttttcttgc tttatccatt gcactgtaaa aattcattta 143880 acctcactta gaagcttcga tgactttaat catgttttct tctgttaatt taatgtccac 143940 ataataatta ttacctttaa atttaacagt agcaccaatt gatttatatt tttcaactaa 144000 ttcttctgat aatttgtagc caaatactcg catttcgcct ttatgtctaa cttcaaattg 144060 tcgaattcca ttaacacgtt tttctaaacg aagttctaaa ttacttctat tttcaaaaat 144120 acctttaata gcgaatggta gaagttcttt cattttatct gcaatatctt tcatttcttc 144180 agtaacacca cgtggtttac gggttgtttt gattttagaa ggattttctt ctgcaaagat 144240 atctgctgct ttaagaataa cttctgttcc ttgttctgtt gcaattaaac catcacctga 144300 tttttcaata aaaccttttt taattaaaac accgatatta gagttaattg aagcagaaga 144360 aatttcagga agagcttcac gaatatcttt agcttggata aaatttgttt tagcaacttc 144420 aagaagaatt gcacctgttt tttcatttaa ttctgaagaa gcttttaaaa cataagataa 144480 tttagacata atagactccg ttaatttgtt atttcgtttt gatgataaga taatactata 144540 cttaaaaagc tttgtaaaca gttattttca ataaaatgca aaaaaggaga ccgaagtctc 144600 cttgtatatg attaataagc aatttttaac ttatcacaaa tttcttttaa atactttata 144660 cgatgttctg gcaaattttt gtccaaaata attaagccat attcatcagg atggtaatca 144720 cccaagaatt tgatttgatg atttattata gcaaactgat tgatattagc atcaaaaaga 144780 tctatagttt ctgctaggcc attcttggct actaaaatat cattattatc acgctggaat 144840 aaagtagtcc acttatctgt gaaatgaggt tcttcgtgtg gtttttctgt atatccttta 144900 gatatcatca actcacgaaa tttttccata tctaatggac aaacccaata atcaatatct 144960 cttggtgggg ttttgtagta ataatctcta gctgctccac caatgatatg ataattaatg 145020 ttattgtcac ttaatatttt agaaatcatt ctttaatagt ccaccctttt ttcgtacata 145080 tctcgtttaa agaacaagaa attccagaaa tagccagatt catctttaat atccccgtta 145140 accatataca aatattcttc tggagaaaaa tactcatgca taattttatg tccatctttc 145200 atggcttcta gagcttcttt tctatccatt aaaaacatta catttctcca gcagaacggt 145260 taaaaaataa attagttttt tccataacat gattaaaaca aacatcccaa tacgaatcaa 145320 aaatagattc taatgatgaa tcgtgttgaa ttttaactga agctttacag aaatcttcaa 145380 atgggacatc aggcattgat ttaccggctg ctgttaaata aattgatgac aaattccatg 145440 ttggattctt aatagtcaac aaagatacta atgcaataaa ttgctcaaaa acttcatatt 145500 ttttaatagg tttcattgta ttttcctcaa taaattttat gtaatattat cacacttaaa 145560 agtctttgta aaccaaaaaa gggacaaaag tccctttatg cattaataga atctatgtct 145620 tttttatatt cagtttctat atcagtggtt ttccagtatt catattcctt tttatattct 145680 ttagccgcct gttctaattt tttaatttcg tctttagtca tatgataaag attcatagaa 145740 attaacttgt cagaaaaggg tttaagatta tcaaactgtt ctatagctgc taaagcatct 145800 ttacgacttt tacctgataa tacaatagtt ttatcaagaa ccattttaat aaaatctact 145860 ttggcttttg cgtaatcata caaatactcg gattctgata atttgatatc aatacgcttt 145920 tgataaaatg gttttcttat ttctacaaaa tatttaatta attcagatgc tttagtaaaa 145980 tcatctctaa ttttaccttt gtcatcaatt actgtaaaaa attgtcctat tttttgagat 146040 aaaccaaatt ctttaatgat ttgttcatga cgttcttctg ggtctgattt aagattaaaa 146100 tcttttttga tagtaatttt aaatctgaat tttacttggc ctgttttttc atcttcacca 146160 gataaatcgt catattcaga aattttaccc tgattaacta attcatctag aatttttgta 146220 gtatatgctt cgcgttccca tttgtatgga acttctgtaa taagaagttg ggttttgcct 146280 ttaagctcat atgtaccttg taattctaca cccgattcag taggaataat cttgccatta 146340 aattgtggaa actgtacttc aggttcttta tctaatttac catcaatagc taattttgta 146400 cattcaacaa cagattttaa tgaatgaggt aaaatattag tagcataacc agtagcaatt 146460 cctttaacac catttaataa aacagttgga ataataggta aataaaactt aggtggaatg 146520 tgttctacat caggatgttc tggagaaata ttaaggtctt tatataaatc aaagaagttt 146580 tgagatatac gacagaacac ataacgagca gcaccgcctt tttggattaa tctagaacca 146640 aatgcaccgc gtccatctaa aaatggaaca ttgttattcc aattattggc cattaattta 146700 ccggcttcag ccgcagaacc ttcaccatga tggtatccaa tttcagcaac accacctgac 146760 aatcctgcta atttatgata tttactttta tcacctttag ctttttccaa ggccctataa 146820 attataaatc gttggacagg tttaaatcca tctataagat ttggaatagc tcgctcttct 146880 acagtgtata aggcatattc tttagcttca ttgttaataa tgctttttaa tgaacgtaaa 146940 ttcaattcca ttatatcttc ctaatgcaaa aaggcctttc ggcctttgtt tttaaaatta 147000 aattattaat tatatttaaa agaataatta tctttaatac gagattttac ttcatacatg 147060 ttattataga tatcagtttc tgttttagct aatttaccaa ataaagttcc gtgtttacca 147120 actttattcg ttagatattt ggcattttcc atagaaacat aatacacttc aatttctgtt 147180 tttgcagata aatggcgttt taactttgca gctggtttaa atttagcagc ctggattttg 147240 ttaatgattg tatataaacc atagtttgta cggaattttt cattaatacg ttgacgaccc 147300 acagtataaa catttaagcc ttcacctgta tttttatcaa caaagaaata aaacccaggt 147360 ttaaacatat tttcatctgt ttgagaattg ataataatat caatattcca agaaccaggg 147420 tttcttgtaa gagtaactac taaatcagaa aaaccagaaa catgttgttt gttaaaacgt 147480 actttattaa aattcataat gacctcattc acgattagat agtatggatg tattataact 147540 aaaaatcctt ggatgtaaat actttaaaac aaaaattttt atctctttta attcttccgg 147600 ttaaatagta gccgtcgaat ttagatttac gaatactacc attctttgta gataaagcgt 147660 attggtctgc taaaatataa ggaatcatcc tgaatgtgtt cagggcaatc ttttctgttt 147720 tgaatataat tataatatct gccacaccaa atttcaagaa cggtcccagg tttatccctg 147780 atgtaccagg acaatctcca tccataccag aattcactac aacccattta gaatttgatt 147840 gatgggtttt tacttctatt cttaatccag agtattttgg gtgagctata acatcataag 147900 catatgtgta tgggtcttca agatcttctt gaccatgatt aataatacca tctacatgtt 147960 ctttgacata ttcttctgcc ataatggcaa tcatacattt ctcaaagcat tctggtacgg 148020 tttgatttgg gttagattcc aacgaatact ttgttgttga acgtattttt tctttagtat 148080 cttcactcat atctcttaaa gacattactt taggctttaa ttctgacaat cttttccatc 148140 caggatttgt ttctaacata ttacctctca acaaaaaaag ggaccgaagt cccttaactt 148200 atttaaatct attttttaaa cttatcagtt acatcttcta gaacagtata accacatgtt 148260 cgcattttag catcgttata atccactgga atagaaacta catcacgtgg atgaactttg 148320 acagaaacta cacggctttt acttccacca aatgatggga tataagactt ggaacacaca 148380 tgtaagccgg aagaacatgt acgattatcg tcttcatcta ctgtattacg tggaacttct 148440 acacgtttac ctggtgaatt atcaaatgta ccactatgac aatctaaata attatcacgt 148500 acgactttcc atgcaataaa atggccatct gctgtgattt cgatatctgt agccattaag 148560 aaatcataca aacgcattac agctttacga cttggattta acattaaatt ttctaagaat 148620 ggtaataaaa atttaaaatc tttaccttct ttcatattag aaataatttt acgagttaat 148680 cctgaatcaa taacaaggtc tttataatac aaagtagaac cttctatttt aatatggccc 148740 tgtgtataag acttgatagc tcgttttgta ttaataaggt ctaacgcttt ttggacatgt 148800 ttgtgttcgg ttttagaatc acctttagaa acggcttcca ttgctttaga cagttcagat 148860 aaagcatctt taaagttttc atggtcttta cctgcgttat atgttttagt tcctactgta 148920 atagaaataa acttactatt agcgttccaa accaaatttt ctaaaatatc tttggtcttt 148980 tctgtatttc ttttagaatt tttaaaatcc acatctgttg tcgatttttt aaaaagatca 149040 atgatataat tattgatatc ttctgctgtt tgctcatcag aacaattata tgcatatata 149100 gtatcttttg attttaactt tccaatacga ataatacccg ggatagctaa gtcacaactt 149160 tgtgcaaaca tatctcgttc tttaggattg ttgatacaaa ccttgtcaca tgtaatagaa 149220 gtatttaatt tagggtcgat aataatttta tctgcaaata cccagtcata tgccaattgt 149280 gaacccggct caggtgtata aatttgtgta gggttttctt ttaaaactct tgtaatagta 149340 tctggcgata cattaaaatg tcgtgcaata agagcttttg acttaccttc aacaaaaaga 149400 ttaaaaacag tttctttttg ttgttgattt aaaattttaa cggacattat aattccttag 149460 gtttcaaata agtattaatg attttaattt gtttttctgt aaattctggc aaattataaa 149520 cataataata taatacaggg tatttttcgc gaatattctt ttcagaattt tcaaattctt 149580 gttctttttg agtttcaagt aaagtcagtt cattgtataa agcttcatca gaacataaaa 149640 gtattctttt taattctaaa tataaataca aatctatagc aggcttgtat tttggattta 149700 ataaaagcat atcaatccat ggaagttctt ttagaacatc acaatttaaa aagtcagaac 149760 tatattcaac aggaatatta ttaatattta aattgaatga tttaatttta tctgaaagca 149820 tatcaatcat attttgtcct tcagaatatt taaatgctgc aggtctaata acatggaatt 149880 cttgtattcc taaaaattca caaagtttaa ttacggctct attagctatg tattgcttgt 149940 ttttgtctga acatataatt gtattatcgt atgaatataa aatgggccct ttaatttctc 150000 ggacttctga tgctgttaag tataagtcgc ttttagaaaa atacttattc catttatctt 150060 ctttcattgt ccaaatttgt acattagaag cttttggacg ggcttcaaca ggtttagaag 150120 ttttgtattt ggttcttaaa taagataaat tatagattga taagtcatca cccatgaaat 150180 cttttatttg ttctaaggtt tgtgtttctg tatcttttaa aacaacacat aatctatcaa 150240 aaccaaaatc ttgcttcatt ccacgaattg tagcaatttt gtctttacct ttacaatcat 150300 caattataac taataaatta gatacaccaa aatttaaaat tgtgctaata ttttgcttat 150360 atttagtaga actatgatta agattactaa ttctaaccaa tttaggatta tcacaaatat 150420 aatatccttg caaatataag tcaggataag ctctatattt cgagtgcaaa tttttaattg 150480 gcccaaattt tttagattca aaatattttt ttaaatattc acacaaacgg tatggtttag 150540 tatttacata tcttagaacg gccctttcag aatcaatatc gtcgatttct ttttggatct 150600 ctgtatatat ttcttttgtt atttcttcaa ctcttctttt aatattgttt accgtgtcgt 150660 cgtcatacga aatttcttca cgagaaggag caatatcaag ttcacctagc ttaaagcgaa 150720 taaatagttt acctggttca cctaaagcac ttattccgga aaagtcaaaa gattcactct 150780 ttaatggata tctaatttta cccataattg cataaacttc tgttgaatca accgataacc 150840 cggaatctgc aaaaaagtat tcatctgtag gtaaataatt aacttgaatc tgtgggccta 150900 caaaattggg tttaatgtca caaaacgtgg caaaaacata tcgtgcttca tgatgccatc 150960 tagaaacatc tttttctaaa acaggaacag ttatttctaa tccagaagga gaatcatctt 151020 caacatcaaa agtaggaatt aacgaaggtt caccattatc tagacaagct gtataaccac 151080 gggcacgtcc ttcaaatctt gatacaatag aaaatgtttc tgtatatcca aatggagatt 151140 tagaacccaa tcctaaagca ccaataaaat cattagaatc cgattttgta gattcaaaat 151200 atgtggtata catatgagtg acatcgtcat cggataatcc tggaccgtaa tcgcgaataa 151260 taaatcttgg gtcaataata gatggcaaag taacgtcaaa aggattaaaa tgacctaata 151320 aagtatgagc atctgcggca ttacagctca attcacgaat aattgctcta atctgattgg 151380 tatataaatt ttgtgacaaa actttaaaag ctttagcaga tgtggcaatt gtaaatttgg 151440 tagaagtttt attactacct aacattattt cattagtatt atgtaatttc attattaact 151500 catttgtcta ttatagtatt aatcatataa cttattatac aaggtactaa tacacgattc 151560 aatatcgggc cctttaatag agtaaaagga cccattgata tacacttcta aaatataacc 151620 catcatttca tggatagcac tttcaacaca atagaaagga gaacattccc ctttatacat 151680 tttattttta tattctatat ggataaccat attatttcct taatcaaaaa atcctggtct 151740 gtcttcaagt tttttatgaa taccaaataa tgcatcttcg atagaaattc catcttcaac 151800 aatggcttct cttctattat taaacacttt aacttgataa gcaactaatt ctacatgtaa 151860 agctgttctt tcataaattg gaagtacgac tgtccgtcgt acgcttcctt tataccaaaa 151920 ccctacttct gtcatgattt catccactct tttctaagat ctgcattatc accaaataac 151980 atttcgaata actcttcata attatcaggc aattccacta tatcgtaaac cgggtcccta 152040 acaacacgtt tatattcatt tgaagttaaa gaagctagtc ctttaatata ccgcggggct 152100 gaccagcctt ttaatttgga tttttctttt tcgtattctt ctacattata ataccatttc 152160 tgttcattac ctttttgaat aataattaaa ggtgttttac aaaaacgaat tctttgttct 152220 ttatatagtt caggccattt agcaaagaat gctaatagcg aaggatatat ggaaccttgt 152280 ccaattatct ctttatttgt gaggtatgtc aatgagtagc ccgaaggcta cccatcaaca 152340 tcggcatcag tcataatagc gatgttatca tacatcatat tactagcggt agaagttctt 152400 ttaacaatag tctgggcttt atatttagtc atatcaatat catttttgtc gatttttgag 152460 aatttcattt ttaacctcgt aatattctgt atttggtttc cagccttgtt taaacatatt 152520 taaggccttc gcatataatt tacttcgttt ttctattcct gtcttcttca tccatttagc 152580 aacaccagtt gcttttggac gagattcatc ataatttgtt atataccagt tgtatagaga 152640 ctctatatta acaatggatt ccttttcagc accaaactta ttaaaccagg gtctagaatc 152700 atttacttct ttagctcttt ttgttgcatt attccagtta ccaataccct taagcccaag 152760 ttcatttatt ttagggtcat caactttgag gcggtatatt ttccctgatt catccttaaa 152820 atttgttaca cctttttcgc cttcaaatct atttccgaaa ttgtttccaa cccattcatc 152880 tttattaaat gttcctttaa caagcaattt gcattttccg gttttaacat ttctcataga 152940 tactttatca gacataaatg ctttagacca tttactaact gcttttctat gggcctttct 153000 tgcgaattca taagaacgag aatttttatt agagttcaac attctaccta aagcgaaagc 153060 catttctttg tttctatgta ttttatacaa taacaaatga gcaaagaaat gttctctaca 153120 tgtaagcttt actaaattag atttgtcgtt tgacccaccc atagacctag gtacaatgtg 153180 atgaatttcg ccttcttcgg caggattctc ctgccgtttt ttaattaaat tattatatat 153240 tttagagtaa ttcactaact ttaacccaag ttccttttat tagaatttcg tcattttcat 153300 taactataac ttcttcacca tctataatag ttttaaacca ttgtccatct ttagcgtatt 153360 caaatgggga ttcacctagt gttaatcctg taatagccat tatatcaaaa gcttctttac 153420 tcttcattat atcaacatct ttcatacccc atgtatttaa gaatttacct cttaaaggat 153480 atccaccttg agtatcttga atacgagaag tcaataattc atttaaagcc gaatctcctt 153540 ctgttaaaaa caatgttgtt cctttacctg gttttccata aaagtttgct ttaatatgtt 153600 ttgcgacttt ggcttttgct gcttttttag ctgctttagt ggctgcagcc tgttctgccg 153660 ctaatttacg ggccaaaaca gcttcaataa taggcatcaa gatggtttca gtcttcatta 153720 attgatttgc aagtttttta acatcaatat ccatgtggtt cttgacttca ccccaggtgt 153780 ttgtcagacg ttcttttgtt tgaccgtcaa atttcatatt actcatatta cggataaaca 153840 ctaggaccgt cagacattct ttaatacggg ctttagtaac ttcaatacga tatttacgtt 153900 taatactagg aataagttcg tttgaaattt catccattaa ccagtcaata tgagaaccac 153960 ctacttttgt atggatctga ttaacaaaag ataagtgtcg gaatccatct ggtgaattag 154020 caaaagctac agaaacatta tcattttcca tagtaattac tttttcacca aattgtgaag 154080 caaatttttt gaagttacct tggatttttt taccattaaa tttaaaagta attttgtcaa 154140 aaataataga taaagtcatt aaacgatctt ggataatatc ttggatagtt ttatcaatac 154200 ctgtgcaatc aaaacgatca aaatctggaa caaatgaaac actggttcct tttaatttac 154260 ctttcttaac agaaaaatta atattttctg cattatcatt acatgtaact gtgatgatat 154320 ttttaccatc acctgtaacg ccttcaaacc aagtactaaa aaagtttgtt aatgaagacc 154380 cgacaccgtt ttgaccgcct gtaacacgtt ccaaatcatt accaaagtta ccacctgcct 154440 ttgttcttgt ccatgcagca acaggcccgg gaatagattc tccttcaggc gtgattacat 154500 tagcttgtgg aataccacgc ccattatctt ttacagtgat tttggaatct ttaatttcta 154560 cttcaatttc atttgcgaat tcaaacttag tacgaatagc ttcatcaatt gaattgtcaa 154620 ttatttcgtc aataattttt acaagacctg ggacataagt gagtgtttta tattcaccaa 154680 aaagaaatct ttcgtgtggt tcgttagaaa cagacccaat atacattgct ggtcttttaa 154740 gacaatgttc tctatcagtg agcattttaa tattattatc tatcatttac tgtcctctca 154800 aattgacgta ctatattttt ataagaacct ttaggaaatc ctctgttaat actttctttt 154860 gaaaatacac taactttagg tttgtttaat tctatccata atttaaataa agcagattca 154920 tatttccata caggacttgt tctatttttt aatccacatt taattaaagc ttcttttgta 154980 tgctttttat tataaaatgg atttttagaa cctttcattg cgatagaatg tttttctctc 155040 ttaagcccat aacacggatt tttatcacct aatttacatt cggacataag ttttaaagat 155100 gatttagtgt gttttttatt ataaaacgga ttgtcttctt tgagcacagg catcccaaaa 155160 aatccattag gagaagccat cgacatatta aaaaatttag tagattttac aacattgttt 155220 aatttttggt atttatactc agcctgaata gcttcttttc ttgtttcaaa cacatctaca 155280 atacacacat caaataaatg tggattattt attttttctt cataataaat ctttttatat 155340 tttttagatc tgacagaacc tgtataacct tcattaaatt tctttaatga agtagatcct 155400 atataaaatg gtgggagctt atctccagaa taaattgtaa gataaactat aaacataaat 155460 tctccgtggt ttccttagtt aaaagggacc gaagtcccta tattattcaa aaaatacatc 155520 tagcaattta cgtattgctt ctgcctgttc ttttgtagta acttccaaat ttagtttaac 155580 tgaattaggc tttaaattaa atacctcacc agttggtggt tccataggca ttacagcaag 155640 tggaacatct ggcatagtaa ctgggagata atctatttct ttacaatatt tttctaagtc 155700 atcatcggaa aaaatatata aaggtgtgtc acttgtatca aattctaacc cgttaaagaa 155760 tctgattgtt tcaaagcatg agtaattgtc ttttgaatag aaaaaaggtg ttcccaccaa 155820 tttattttcg gtaacaaatt tttcaaattc tttagcccat acagttccgt tatcaagaat 155880 aaacgcatca aaggccgatt gtgatttaaa aacataacgt tccatatagt caaacatatt 155940 actgtccttt aaggtgttct agtaattcat taataaagat aacaagttct gttttagaat 156000 ttaaagtttt tgcaggaatg tctaatttaa attcttcttt ttgatttgag tttttatctt 156060 ttgagacaat tacaaagaat tctctaaatt gtttatcttc tgttttaaat gttaatgcac 156120 tactgtgaat agggatagtg taagacggat aatataaatc agaaaattct aatccattat 156180 caaaaacaca tcttaaaaat gtattttctg tacgattaaa ataaactgaa aatggcatat 156240 cttgtaagtt gttgtatata acaaaatctg caaaactaga ttgggcatta caaaaactac 156300 cgtatcttga tacgttaaca ccctttttaa attttaggcg tccaataagt tcttctttca 156360 taattatgat tccaagtatt ctaataattc attgatcact gcttttgctt cagctttatt 156420 agtaatcgtt ttattaatta ctaactcttt agaatttaag acttgctccg gtttctcaat 156480 atcttttaca gcttcaataa atttaaaatt agaatgcctt agttcacatt tagaaccttc 156540 aatattaagt ccaaatgtat agaagtctaa cccagcatct gaaaatacca taccattatc 156600 aaatacaatt tctaaatcat accaagccgg gttggtttca attaaatcaa tggtaaaact 156660 atggtgtttt aataaatact tatctaaaaa gtcagaaaat aatacacgtg ttgtattaaa 156720 ttcttgttgt tctacatagt gtttgatact aattggagat ttaaatttaa atctccctaa 156780 tgatttaata aatttgctca tagcacggcc ttagcccatt tagtggtttt agatttaatt 156840 tgttcattta aatcatcaat aacaatacac attaggtctt tatcattgac aagttcaaat 156900 tcttgtttat tacgatagtt aagccataat gtatcaatta agcaattaat aacatcagcg 156960 gcttcgccag ttgcacattc gtcaacttca tcttgtcgaa atgtagcttt agagtattca 157020 ccaatttctt cgactaaatg ggcaaaaact atacttaaat cacgttctgg tgctttaata 157080 cacattttaa cggtcgggct gatatctaaa attggttcac aatcaaaatc aggttctttt 157140 aatggttctt tgaagacaat cggtgtttgt tcatattgaa taatctgaat acctgataat 157200 tcaaaaaact cttgttctct ggaatcataa gtgtaaccac cgagtttaga taaacaaaca 157260 aatgagccaa atgattcatt taaattagta tatataattc cgttaatata tacagctaaa 157320 ggattgccat aatcatctgt ttttaaaatc gtgacaattt tagatttagt attatgtaaa 157380 aatttaaaaa taggataaag acgtctttgt tcttctgttt cgggccagaa tttatttaat 157440 ttataagaac ggccttcttt gaacataggt tgacgagtaa atgattcatc tagagtttgt 157500 tcacctaaaa cacaccagaa tgagtcatca tttgataatt caacaatttg attattgact 157560 aaaattttag atgcaccata atattgcatt gcgttggaaa ccgtcacatc taaaatttgg 157620 acttccatgt tatcaaaaag acgaattcca cggtcttcca tgattctata aaatgcactg 157680 acttggttta aagaagccag gtttaatgta tagatagaac ctttactaat cataatatta 157740 tccttttaaa ttttcaaaga aaaaatcagt tttaacagta ctaccacaag aactgataac 157800 acgtttataa acagcaacgg cttcattatt ttcaataaca tataaattcg tcagatgaat 157860 catatgagac acttctgaat ctttttgaac aacagttaaa gtgtttgaaa ataaaacatc 157920 ttcaaattca tcacgtgtaa ttacttgttc cattataaac tcccgttatt tgttttgttt 157980 gtttcgtttt gttgtaaata taatacaaaa taaaagaggt cttgtaaacc tcttttttca 158040 ctttttaaaa ctattttttg atagatacta ggtctatgtc tttttcttca ggaacttctt 158100 caagtccaag cgcatatcgt tctgctgttt taagcataat aatgtcttta gcacagtcat 158160 gaatagagtc gtgtaaaaca aacccattta aaacaccttt acgaatagga catatagtca 158220 tgtctctgtc taataaaagt tttctaatag aagtccttgt atcattttga ttccaaaaag 158280 cgataaattc tttcttaaac gtatctacgt cttctaaagc tattccagat tctaattcac 158340 gttgggtgat catatgtttt aaaataggaa agtcgaacga cataccacga ctatatcctt 158400 gagatttcca gaaatcaatt ccttgggcat ctaaataatt ctttaatata tctagacctt 158460 cattaatcgt aacgtcctgt ggtgttctaa caagattctt tttagcttca ggttcttgtt 158520 gtttccacca ttctactgtg gatttataga atactctttt acctttttgt gaattcaaat 158580 caaacttaat acgcaaccca cgtttaacaa gatcttcaaa agattctact acattagggt 158640 ccgggttaaa agtaataata gataaatcta taacagccga atccggttgg ttaccaaaag 158700 tttctaagtc aaatacaaaa tcaatcatat ataccacaca tttttctgag cccgtgttgt 158760 tccaacatac aatagttgtg aagcaacatc tacttctgca tattttataa tacaaggagt 158820 ataaagaaaa ctatttttta cggttacacc ttgtgcctta tggattgtac tacatggaat 158880 gggttttact tttgtgaaag catctttaat ttcccagaag tcatcccaat aagcgcgtcc 158940 attgcctgat ttatattgtt gtgcaacttt acctaaaaac atccaaagct gggtttggtt 159000 ttcttctcca taaacaacat taagataatt ggttgtgcct tcatcaacag attggacttt 159060 taaaagaaag taaggtaaat cgattttaaa atcaacccca cgacactgaa gttttctaga 159120 catttccttt acgtctagaa tttgcacaac ttcaccatta ttaaagatga tttctttcat 159180 ctttttgcct tcaaatttta tagtttgcat atatggttct tgcataacta aagcttcacc 159240 aataataaat ggatcatctt ttttataaaa gtttttacgg atgatttgat ttaacttatc 159300 aacagattta ttagtataag caaaaaatct attatcaaag aaatcttctt cagattttat 159360 ttgcttaaaa taatctatca tcatatcacg taaagaaggt ggatgaaaaa taccttcgcc 159420 atcaataatg ttttctctaa tccatccacc ttctctaatt tctgtagcaa cttcaataat 159480 tggttgattt gaacgcttta cttcagtcag atgcatttgt ttaaaccgat gatctgtaaa 159540 aaatctagat acacccaggt catcttgagg ttttaactgg gctttatctc cgatagcaat 159600 aacaatagtc catggcatga tgttgttcat taaaagctca aataattttg tatcatagaa 159660 cgaagcttct tcacagatta atacacgaat tttatctaac tcaggggcct ttctttgttc 159720 aaaaatccga tgttcttcat aagttacagg atttattttt aaaatactgt ggattgttga 159780 tacttctcgc ccagtaaaat cagccagtac ttttttagaa gcatgggttg gcgcagctaa 159840 aacaactcca gggatccctt ctttttcgat gaaatccata ataaacttca ttaataaact 159900 tttacctgta ccagcaggtc cgttaattgt taaatgagtt gttttggctt tccagttgga 159960 ttcttgttta tatgcttgtt gaatcaaatc tgttgcacat tcgtaggctt ctttctgacc 160020 ttgagttagg tcatcaaatt caatcatact attttcacct ttttaatata aagtgtatct 160080 aacattcgct tttggagtgt cgtcaaatat tctggtttat ggattaaaat tttttcctct 160140 cgtttaaacc agagaaatct tttatattgt attttgtatt taggtttaag ctcattaata 160200 atatattctt taaaacgatt aaaggcctca ttgcagagac cttttgtttt atatatcatt 160260 aaagcttgtg tgtcaggatt ctggcataat atatcaaatc ctgctacgtc tttgtagact 160320 atcgcataat aatacataaa gttcttttcc tactctttta taagaagaat ctaatgaaat 160380 acctaaatat aattttaact tatcatactt agatagctta ttaaatcgtt cttcggcttt 160440 ataaagaaca tttaaaattc taagacttct atctttcttt tgtatgcatc tttcatgttg 160500 ttcttctaaa tttttaagag acttttcttg ttgattaacc cggtttctta gttttttatt 160560 atttgagttc atactaagtc tttttttatt gataataagt ttagacctaa actttgttat 160620 ggatgaaatc gcttcatttt tctctttatt tacactatta attttctttt taatatcttc 160680 tagtgtcata gaacttttat aacaattata ttctccttta acaggaatca cattaccttt 160740 aacataccct ttagaattat caaatctttc aaaagatata ccttcaaggt cattacaatg 160800 tttaggcata gacatcgatt cgccagaata tgcacacgtt gtttgttcgc aaatgttttt 160860 aacatatctc aaagacaaat taaattcttt atttcttgat ttggcggatt tatggatttg 160920 ggtgtatttt ttaatcacat cttcaatttg catgatgacc tcctagaata attgagagac 160980 aatatacaac attctaggag gtttgtaaac tagttaatgt aaactatttt tccgttaata 161040 gaataagtaa tagacacttc ttttttatgt tgttttttaa tattttccgg atagatagga 161100 agaatagaat caacaattct caattggtct tctgtactca tagaagggct aacaggatag 161160 cccattttat tgagaatttt agacatttga aataacgtta acattaatat cctcgttctt 161220 ggcgagcaaa gttttctgca ttttttaagt aatatagaac aaaaatttct tcagaagaca 161280 tgccaagacc gataagttta ttcataaaga aatgaacctg gtcaataagt tcaaatttga 161340 cttctaattg atcggcttca gataattcag aaaatggttt attcgacatt tcttcatggc 161400 gagctttcca aggtttccat actgctgatg cttctttatc gccattagac atcccgccta 161460 aagaagtata caactcacgg gtttcgtcgt ttaaatagtc atcttgacta cgcatccatt 161520 taagaatatc accacatgtt tttaattcat caggcgattg gttattaaat ggtttggttt 161580 ttgctaagaa aacttgtaaa gatttttgca tatctaacat tacttgtaaa gggtcttgtc 161640 ctgaactaat aatatcagaa tatgcttcac gagcttttgt taaagaacct tcatccacta 161700 aagttgaaca tacattaaaa tgagccattg ttattcctta ttcaaaatat tttaaagttt 161760 tttctgggta attaacacaa acaccagtac ataatacatc attacttaat gacgcatcta 161820 aagaccattt tttattttca ggttcccacg taggtttttt gatagaagat tgcacagaac 161880 cattatatga agtaaaaaca tattggtgtg attgtttaat aaaaagggct ttaccaaaat 161940 actggacttg tttatacttt acttctccac aattatccca attaataaat ggctttgaca 162000 actcatctaa tttttcattt gcttcttcta atgtagaaaa acaattttca catggagttg 162060 ttccaacata ataccaaatt cttggttctg aactggggct ttcgacaaaa attaaatcca 162120 tcagtctgta attattagtc tcgccattat cccactgcac atcaatacca aaatcatcta 162180 cgtctaaaga atctttgtcg atattagata tagttccttt gcacggggga tttctacttc 162240 cggcatgtgt actataaaac tcagaaccag ggtgtatttt tactctattt ccaactacag 162300 catgtttaat atccattata ctttccttaa atttaaggac ctgattaatc ggtccttcat 162360 ataattatta aaaagactta tttatgattt cagacatttt agataaagct tcatactcag 162420 tagcaaattc ataagatatc ttatgaaatt tgacaacata cactagttct gggccgggtt 162480 ctactaaatc tttttcacta tctactaaat ctttttcact ataagtattc tttaaaccat 162540 tatcccattg tacttttatt gataatccga aagcagattg gacatgaata tcttctatag 162600 tcccgacaat tttaggatta gccttaccta aattatagta ttctgacgtc tttttaattt 162660 ttacgcgatc accgacttta aaaaccatat tattcctcta aaattctcaa tgctaattga 162720 acatcataaa aagataatcc aattagcccg ttaacttgga caaaattgcc acctaaacca 162780 tatacataat gctcgataga atcatctaat acaacatatt tttcgacttc atggtctaaa 162840 acatatctta atatactttc accacgggat cgtccacagc cagtaaaatc tattgtatca 162900 tggatgtcta cgcctaaaac ttcagaaatt tctttttctc tatctttata atcatcatgc 162960 tttgatgatt tggcccatga agaaattaag acaaccttag catcagtaga tgctagtaat 163020 tttttaaatc gatttaattc tttgatgcca atatatccta atttagatct aatagctaaa 163080 tcatcattaa aacaagatac ttggctgttt aatacaccat caatatcaag aaatatcact 163140 tttaattttg actgaactgg gtcttttgaa gaatgcatga gttttatcat ccttagcttg 163200 ttcaaatgtt gctttaaatt caatttcacc acggtaatct aatggcacac atttaggtag 163260 tgatccgtat actgttgatt tattttcaag ctcaacggtc attttagaaa ctatcccata 163320 aaaatcttca tatgttttaa ctcttaaaac tgttcctttt attacttgtt taccatcagg 163380 ggcttcacct ttgtcttttt tgtggtcatt atatatgtca tcaaacactt tgtttgaata 163440 ttcctgaata gctacaagaa attttctat 163469

Claims

Bacteriophage PM2 consisting of the nucleotide sequence shown in SEQ ID NO: 1, having the killing activity specific to Proteus mirabilis .

2. The bacteriophage according to claim 1, wherein the bacteriophage is a deposit number KFCC 11678P.

A pharmaceutical composition for preventing or treating an infectious disease caused by Proteus mirabilis comprising the bacteriophage PM2 of claim 1.

4. The method according to claim 3, wherein the infectious disease caused by the Proteus mirabilis is at least one selected from the group consisting of acute pyelonephritis, acute cystitis, chronic cystitis, sepsis and pneumonia. Or a pharmaceutically acceptable salt thereof.

The method of claim 3, wherein the infectious disease is bakteo to keulrep when Ella (Klebsiella) genus Pseudomonas (Pseudomonas) genus Enterococcus (Enterococcus) genus, Staphylococcus (Staphylococcus), An Escherichia (Escherichia) in the site and Wherein the infection is caused by a combined infection of one or more strains selected from the group consisting of Citrobacter and Proteus mirabilis, and a pharmaceutical composition for preventing or treating an infectious disease caused by Proteus mirabilis.

An antibiotic composition comprising the bacteriophage PM2 of claim 1.

A composition for feed addition comprising the bacteriophage PM2 of claim 1.

A feed comprising the feed additive composition of claim 7.

A disinfectant comprising bacteriophage PM2 of claim 1.

A cleaning agent comprising the bacteriophage PM2 of claim 1.

A method for preventing or treating an infectious disease caused by Proteus mirabilis, which comprises the step of administering the bacteriophage PM2 of claim 1 to an animal other than a human.