KR102432624B1 - Novel Staphylococcus specific bacteriophage OPT-SC01 and antibacterial composition comprising the same - Google Patents

Novel Staphylococcus specific bacteriophage OPT-SC01 and antibacterial composition comprising the same Download PDF

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KR102432624B1
KR102432624B1 KR1020200127149A KR20200127149A KR102432624B1 KR 102432624 B1 KR102432624 B1 KR 102432624B1 KR 1020200127149 A KR1020200127149 A KR 1020200127149A KR 20200127149 A KR20200127149 A KR 20200127149A KR 102432624 B1 KR102432624 B1 KR 102432624B1
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서련회
김영주
김현일
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Abstract

본 발명은 스타필로코커스균, 특히 스타필로코커스 크로모게네스(Staphylococcus chromogenes)에 특이적인 사멸능을 갖는 신규 박테리오파지 OPT-SC01, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 OPT-SC01을 이용한 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 스타필로코커스균에 대한 특이성이 매우 높고, 상기 박테리오파지 OPT-SC01은 스타필로코커스균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 OPT-SC01은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 OPT-SC01은 스타필로코커스균, 특히 스타필로코커스 크로모게네스에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 분야에서 다양하게 사용될 수 있다.The present invention provides a novel bacteriophage OPT-SC01 having a specific killing ability on Staphylococcus bacteria, particularly Staphylococcus chromogenes , an antibiotic composition comprising the bacteriophage, a composition for adding feed, feed, disinfectant or It relates to a method for preventing or treating an infectious disease caused by Staphylococcus bacteria, comprising administering to the subject a detergent and the bacteriophage. The method for preventing or treating infectious diseases caused by Staphylococcus bacteria using the bacteriophage OPT-SC01 of the present invention has very high specificity for Staphylococcus compared to conventional chemicals such as antibiotics, and the bacteriophage OPT-SC01 is a star It has the advantage of excellent lytic activity and strong resistance to physical and chemical stimuli by being infected with and proliferating within the bacteria. In addition, since the bacteriophage OPT-SC01 of the present invention does not infect other hosts other than bacteria, such as humans, animals, and plants, the problem of antibiotic-resistant bacteria due to the misuse of antibiotics, the residual problem of antibiotics in food, and the problem of a wide host range. There are advantages. Therefore, the bacteriophage OPT-SC01 of the present invention can be used variously in the field of prevention or treatment of infectious diseases caused by Staphylococcus bacteria, particularly Staphylococcus chromogenes, antibiotic composition, composition for addition to feed, feed, disinfectant or detergent. can

Description

신규한 스타필로코커스균 특이 박테리오파지 OPT-SC01 및 이를 포함하는 항균 조성물{Novel Staphylococcus specific bacteriophage OPT-SC01 and antibacterial composition comprising the same}Novel Staphylococcus specific bacteriophage OPT-SC01 and antibacterial composition comprising the same

본 발명은 스타필로코커스균, 특히 스타필로코커스 크로모게네스(Staphylococcus chromogenes)에 특이적인 사멸능을 갖는 신규 박테리오파지 OPT-SC01, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.The present invention provides a novel bacteriophage OPT-SC01 having a specific killing ability on Staphylococcus bacteria, particularly Staphylococcus chromogenes , an antibiotic composition comprising the bacteriophage, a composition for adding feed, feed, disinfectant or It relates to a method for preventing or treating an infectious disease caused by Staphylococcus bacteria, comprising administering to the subject a detergent and the bacteriophage.

스타필로코커스 크로모게네스(Staphylococcus chromogenes)균은 그람양성의 구균으로 낙농 동물의 유방염과 관련이 많은 세균으로 알려져 있다. 일반적으로 사람의 피부, 동물의 피부, 환경에서 흔히 발견되며 응고효소(coagulase)를 생성하지 않는 응고효소 음성인 포도상구균(coagulase-negative staphylococci, CNS)으로 간주된다. 황색포도상구균(Staphylococcus aureus)과 같이 젖소의 유방염을 일으키는 주요 병원균으로 알려져 있다. Staphylococcus chromogenes is a gram-positive cocci and is known as a bacterium associated with mastitis in dairy animals. Commonly found in human skin, animal skin, and the environment, it is considered a coagulase-negative staphylococci (CNS) that does not produce coagulase. Staphylococcus aureus is known as a major pathogen causing mastitis in cows.

CNS 그룹 내에서 대부분의 유방감염은 스타필로코커스 크로모게네스균과 관련 있으며, 특히 스타필로코커스 크로모게네스균은 젖소의 숙주 적응 CNS 종으로 유방과 소에서 생존하는데 특화되어 있다. 또한 착유 및 착유자의 손에 의해 쉽게 전파되어 농가 내에 전염성 유방염을 발생시킬 수 있다. 전파된 세균으로 인해 염증이 초래되고 유방 세포 손상으로 인한 모유 체세포수를 증가시켜 원유의 품질을 저하시킨다. 또한 유방염에 한번 감염되면 회복 후는 물론 다음 유기가 되어도 산유량이 정상으로 회복되기 힘들며 병든 젖소는 발열과 식욕저하 등을 일으키며, 심할 경우 폐사로 이어진다. 국내 목장에서는 젖소 원유 생산을 통해 약 22,000억원의 수익을 창출하고 있으나, 유방염 발생에 의해 연간 약 2,000억원의 경제적 피해가 보고되고 있다. Most mammary infections within the CNS group are related to Staphylococcus chromogenes, particularly Staphylococcus chromogenes, which is a host-adapted CNS species of cows specialized for survival in breasts and cattle. In addition, it can be easily spread by milking and milking hands, causing infectious mastitis in farms. Inflammation is caused by the spread of bacteria, and the number of somatic cells in breast milk increases due to damage to the breast cells, thereby reducing the quality of raw milk. In addition, once infected with mastitis, it is difficult to recover the milk production after recovery and even after the next abandonment, and sick cows cause fever and loss of appetite, and in severe cases, it leads to death. Domestic ranches generate about 220 billion won in profit through the production of cow's milk, but economic damage of about 200 billion won is reported annually due to mastitis.

포도상구균 감염으로 인해 발생한 젖소 유방염을 치료하기 위해 유방에 직접 항생제를 투여하는 치료법이 일반적이다. 하지만 젖소의 유선은 항생제 치료가 곤란한 부위이다. 사용되는 항생제는 투여 시 분방의 감염 부위에까지 도달해야 하며, 감염부위에는 치료에 충분한 농도로 일정기간 동안 유지되고 모든 세균을 사멸시키는 약제가 선택되야 하는 어려움이 존재한다. 더불어 가장 큰 문제는 항생제 내성으로 스타필로코커스 크로모게네스균이 속해있는 CNS는 페니실린(penicillin)에 대하여 황색포도상구균보다 항생제 내성이 더 많이 나타나며, 쉽게 다제내성이 되는 경향이 있다고 알려져 있다. 현재 젖소 유방염 치료제로 겐타마이신(gentamicin)이 쓰이고 있으며 이의 남용은 또 다른 항생제 내성균주의 출현을 초래할 수 있는 심각한 문제로 보고되고 있다. 또한 항생제 사용으로 인해 원유에 항생제가 잔류하게 된다. 목장에서는 자체적인 우유 잔류물질 검사를 통해 원유에 존재하는 항생제 잔류물질을 제한하고 있지만 2018년 식약처에서 우유 잔류물질 오염실태에 대한 조사를 한 결과 원유에서 잔류 허용 기준치 이상의 항생제가 발견됐다고 보고되었다. 이에 농림축산식품부에서는 2020년 7월부터 원유에 대해 국가 차원의 검사 프로그램을 시행하여 원유 항생제 잔류물질 검사 체계를 강화할 것이며 오남용되는 항생제 사용 축소를 권고하고 있다.To treat cow mastitis caused by a staphylococcal infection, the treatment is to administer antibiotics directly to the breast. However, the mammary gland of cows is a difficult area to treat with antibiotics. The antibiotic used must reach the infection site of the branch when administered, and there is a difficulty in that an agent that is maintained at a sufficient concentration for treatment for a certain period of time at the infection site and that kills all bacteria must be selected. In addition, the biggest problem is antibiotic resistance. The CNS, to which Staphylococcus chromogenes belongs, is known to exhibit more antibiotic resistance to penicillin than Staphylococcus aureus, and it is known that it tends to become easily multi-drug resistant. Gentamicin is currently used as a treatment for cow mastitis, and its abuse is reported to be a serious problem that can lead to the emergence of another antibiotic-resistant strain. In addition, antibiotics remain in crude oil due to the use of antibiotics. Although the ranch limits antibiotic residues in raw milk through its own milk residue test, the Ministry of Food and Drug Safety conducted an investigation into the contamination of milk residues in 2018. Accordingly, the Ministry of Agriculture, Food and Rural Affairs will implement a national inspection program for crude oil from July 2020 to strengthen the crude oil antibiotic residue test system and recommend reducing the use of misused antibiotics.

한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.On the other hand, a bacteriophage refers to a bacteria-specific virus that infects a specific bacteria and inhibits and inhibits the growth of the infected bacteria. Bacteriophage has the ability to kill bacteria by destroying the cell wall of the host bacteria when the bacteriophage proliferates inside the bacterial cell after infection (infection), and the progeny bacteriophage comes out of the bacteria after proliferation. The bacterial infection method of bacteriophages is very specific, so the types of bacteriophages that can infect specific bacteria are limited to some. That is, a specific bacteriophage can only infect a specific category of bacteria, thereby killing only a specific bacteriophage and not affecting other bacteria. Therefore, the use of bacteriophage as a countermeasure for bacterial diseases has recently received a lot of attention. In particular, the limitations of existing antibiotics appear due to the increase of antibiotic-resistant bacteria after 2000, and as the possibility of development as an alternative to existing antibiotics is highlighted, bacteriophages are again attracting attention as anti-bacterial agents.

이에 본 발명자들은 스타필로코커스균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 스타필로코커스균, 특히 스타필로코커스 크로모게네스균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.Accordingly, the present inventors isolate a bacteriophage having a lytic activity specific to Staphylococcus, and analyze the morphological and genetic characteristics of the isolated bacteriophage, and the bacteriophage is Staphylococcus, particularly Staphylococcus chromogenes. By confirming that it can be killed, the present invention was completed.

본 발명의 목적은 스타필로코커스(Staphylococcus)균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-SC01을 제공하는 것이다.An object of the present invention is to provide a bacteriophage OPT-SC01 consisting of the nucleotide sequence represented by SEQ ID NO: 1 having a specific killing ability to Staphylococcus bacteria.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-SC01을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.Another object of the present invention is to provide an antibiotic composition, feed additive composition, feed, disinfectant or cleaning agent, including the bacteriophage OPT-SC01.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-SC01을 개체에 투여하는 단계를 포함하는, 스타필로코커스(Staphylococcus)균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.Another object of the present invention is to provide a method for preventing or treating an infectious disease caused by Staphylococcus bacteria, comprising administering the bacteriophage OPT-SC01 to an individual.

상기 목적을 달성하기 위하여, 본 발명은 스타필로코커스(Staphylococcus)균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-SC01을 제공한다.In order to achieve the above object, the present invention provides a bacteriophage OPT-SC01 consisting of the nucleotide sequence represented by SEQ ID NO: 1 having a specific killing ability for Staphylococcus bacteria.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 항생용 조성물을 제공한다.In addition, the present invention provides an antibiotic composition comprising the bacteriophage OPT-SC01.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 사료 첨가용 조성물을 제공한다.In addition, the present invention provides a composition for addition to feed, comprising the bacteriophage OPT-SC01.

또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는, 사료를 제공한다.In addition, the present invention provides a feed comprising the composition for adding the feed.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 소독제를 제공한다.In addition, the present invention provides a disinfectant comprising the bacteriophage OPT-SC01.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 세척제를 제공한다.In addition, the present invention provides a cleaning agent comprising the bacteriophage OPT-SC01.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 개체에 투여하는 단계를 포함하는, 스타필로코커스(Staphylococcus)균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.In addition, the present invention provides a method for preventing or treating an infectious disease caused by Staphylococcus bacteria, comprising administering the bacteriophage OPT-SC01 to an individual.

본 발명의 박테리오파지 OPT-SC01은 기존의 항생제 등의 화학물질에 비해 스타필로코커스균에 대한 특이성이 매우 높고, 상기 박테리오파지 OPT-SC01은 스타필로코커스균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 OPT-SC01은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 OPT-SC01은 스타필로코커스균, 특히 스타필로코커스 크로모게네스균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 분야에서 다양하게 사용될 수 있다.Bacteriophage OPT-SC01 of the present invention has a very high specificity to Staphylococcus compared to conventional chemicals such as antibiotics, and the bacteriophage OPT-SC01 is infected with Staphylococcus and has excellent lytic activity by proliferating within the bacteria. It has the advantage of being strong against physical and chemical stimuli. In addition, since the bacteriophage OPT-SC01 of the present invention does not infect other hosts other than bacteria, such as humans, animals, and plants, the problem of antibiotic-resistant bacteria due to the misuse of antibiotics, the residual problem of antibiotics in food, and the problem of a wide host range. There are advantages. Therefore, the bacteriophage OPT-SC01 of the present invention is Staphylococcus bacteria, particularly Staphylococcus chromogenes, preventing or treating infectious diseases caused by bacteria, antibiotic composition, composition for feed addition, feed, disinfectant or detergent in various fields. can be used

도 1은 전자 현미경을 통해 박테리오파지 OPT-SC01의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 OPT-SC01의 세균 사멸 능력을 평가한 결과를 나타낸 도이다.
도 3은 박테리오파지 OPT-SC01의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 OPT-SC01의 열 안정성을 확인한 결과를 나타낸 도이다.1 is a view showing the results of confirming the morphological characteristics of the bacteriophage OPT-SC01 through an electron microscope.
Figure 2 is a diagram showing the results of evaluating the bacterial killing ability of the bacteriophage OPT-SC01.
Figure 3 is a view showing the results of confirming the pH stability of the bacteriophage OPT-SC01.
Figure 4 is a view showing the results of confirming the thermal stability of the bacteriophage OPT-SC01.

이하, 본 발명에 대해 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 스타필로코커스(Staphylococcus)균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-SC01을 제공한다.The present invention provides a bacteriophage OPT-SC01 consisting of the nucleotide sequence represented by SEQ ID NO: 1, having a specific killing ability to Staphylococcus bacteria.

본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.In the present invention, the term bacteriophage is a bacteria-specific virus that inhibits and inhibits the growth of a specific bacterium by infecting the bacterium, and refers to a virus containing single or double-stranded DNA or RNA as a genetic material.

본 발명에 따른 박테리오파지 OPT-SC01은 전체 유전자의 크기는 142,961 bp이며, GC 함량은 31%, ORF(open reading frame)의 수는 214개이다. 또한 상기 박테리오파지 OPT-SC01의 전체 유전자 서열은 서열번호 1로 표시될 수 있다.The bacteriophage OPT-SC01 according to the present invention has a total gene size of 142,961 bp, a GC content of 31%, and the number of open reading frames (ORFs) is 214. In addition, the entire gene sequence of the bacteriophage OPT-SC01 may be represented by SEQ ID NO: 1.

또한 상기 박테리오파지 OPT-SC01은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 OPT-SC01은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.In addition, the bacteriophage OPT-SC01 may include the nucleotide sequence represented by SEQ ID NO: 1 as a whole or a part of the entire gene. In addition, the bacteriophage OPT-SC01 of the present invention may consist of a nucleotide sequence represented by SEQ ID NO: 1, and a functional equivalent of the nucleotide sequence. The functional equivalent means at least 70% or more, preferably 80% or more, more preferably 90% or more, even more preferably 95% of the nucleotide sequence represented by SEQ ID NO: 1 as a result of modification and substitution of the nucleotide sequence. As having the above sequence homology, it means a sequence that exhibits substantially the same physiological activity as the nucleotide sequence represented by SEQ ID NO: 1.

본 발명에서, 상기 스타필로코커스균은 스타필로코커스 크로모게네스(Staphylococcus chromogenes), 황색포도상구균(Staphylococcus aureus), 표피포도상구균(Staphylococcus epidermidis) 및 스타필로코커스 자일로서스(Staphylococcus xylosus)으로 이루어진 군에서 선택된 1종 이상이나, 이에 제한되는 것은 아니다. In the present invention, the Staphylococcus bacteria is a group consisting of Staphylococcus chromogenes , Staphylococcus aureus , Staphylococcus epidermidis and Staphylococcus xylosus . At least one selected from, but not limited thereto.

본 발명의 박테리오파지 OPT-SC01은 도계장 부근의 시료로부터 분리한 박테리오파지로서, 본 발명자는 박테리오파지 OPT-SC01로 명명하고 2020년 9월 9일에 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하여, 수탁번호 KFCC11863P를 부여받았다. 상기 박테리오파지 OPT-SC01은 'SC01'로 표시할 수 있으며, 수탁증에 표시된 'Staphylococcus chromogenes bacteriophage SC01’과 동일한 생물이다.Bacteriophage OPT-SC01 of the present invention is a bacteriophage isolated from a sample near the slaughterhouse, the inventor named the bacteriophage OPT-SC01 and on September 9, 2020, the Korea Culture Center of Microorganisms (Korean Culture Center of Microorganisms, Seoul, Korea) and was given an accession number KFCC11863P. The bacteriophage OPT-SC01 may be denoted as 'SC01', and is the same organism as 'Staphylococcus chromogenes bacteriophage SC01' indicated in deposits.

본 발명의 박테리오파지 OPT-SC01은 스타필로코커스 크로모게네스에 대해 용균활성이 탁월하다. 상기 박테리오파지 OPT-SC01은 230-250 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속한다.Bacteriophage OPT-SC01 of the present invention has excellent lytic activity against Staphylococcus chromogenes. The bacteriophage OPT-SC01 has a size of 230-250 nm, has an icosahedral head, and belongs to Myoviridae , which is a form having a contractile tail.

또한 상기 박테리오파지 OPT-SC01은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.In addition, the bacteriophage OPT-SC01 has excellent stability to heat and pH.

상기와 같은 스타필로코커스균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 OPT-SC01을 스타필로코커스균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 OPT-SC01을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.Staphylococcus specific lytic activity, acid resistance, basic resistance and heat resistance as described above is effective for the bacteriophage OPT-SC01 of the present invention for preventing and treating infectious diseases caused by Staphylococcus bacteria, and the bacteriophage OPT-SC01 is effective In application to various products included as a component, it enables the application of various temperature and pH ranges.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 항생용 조성물을 제공한다. In addition, the present invention provides an antibiotic composition comprising the bacteriophage OPT-SC01.

본 발명에서, 용어 항생용 조성물은 약제 형태로 동물에게 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다. In the present invention, the term antibiotic composition refers to an agent that is provided to animals in a pharmaceutical form to kill bacteria, and is a generic term for preservatives, bactericides, antibiotics and antibacterial agents.

본 발명의 박테리오파지 OPT-SC01은 기존 항생제에 비하여 스타필로코커스균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.Since the bacteriophage OPT-SC01 of the present invention has very high specificity for Staphylococcus compared to conventional antibiotics, it does not kill beneficial bacteria, can only kill specific pathogens, and does not induce drug resistance or resistance, so existing antibiotics Compared to that, it can be used as a new antibiotic with a long life cycle.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 사료 첨가용 조성물을 제공한다.In addition, the present invention provides a composition for addition to feed, comprising the bacteriophage OPT-SC01.

축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞어 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 OPT-SC01을 이용할 수 있다.Antibiotics for addition to feed used in livestock and fisheries are used for the purpose of preventing diseases. When antibiotics are absorbed into the body through meat, they can lead to antibiotic resistance, which can lead to the spread of diseases. In addition, since there are many types of antibiotics mixed with feed and there is a problem that the probability of occurrence of multi-drug-resistant bacteria increases, the bacteriophage OPT of the present invention is more natural-friendly and as a new antibiotic for feed addition that solves problems caused by the use of existing antibiotics -SC01 can be used.

또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조 상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.In addition, the present invention may provide a feed comprising the composition for adding to the feed, and the feed of the present invention may be prepared by separately preparing bacteriophages in the form of a feed additive and mixing them with the feed, or by directly adding them during feed production. . The bacteriophage in the feed of the present invention may be in a liquid or dry state, preferably in a dried powder form. The drying method may include, but is not limited to, ventilation drying, natural drying, spray drying and freeze drying. The bacteriophage of the present invention may be mixed in a powder form in a component ratio of 0.05 to 10% by weight, preferably 0.1 to 2% by weight of the weight of the feed. In addition, the feed may further include conventional additives that can increase the preservation of the feed in addition to the bacteriophage of the present invention.

본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해 효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에(Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.Other non-pathogenic microorganisms may be additionally added to the composition for adding feed of the present invention. Examples of microorganisms that can be added include Bacillus subtilis , which can produce proteolytic enzymes, lipolytic enzymes and sugar converting enzymes, Lactobacillus having physiological activity and organic matter decomposition ability under anaerobic conditions such as the stomach of cattle. Strain ( Lactobacillus sp. ), filamentous fungi such as Aspergillus oryzae , and Saccharomyces cerevisiae , which increase the body weight of livestock, increase milk production, and increase the digestibility and absorption rate of feed ) can be selected from the group consisting of yeast such as

본 발명의 박테리오파지 OPT-SC01을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.The feed containing the bacteriophage OPT-SC01 of the present invention includes grains, root fruits, food processing by-products, algae, fibers, pharmaceutical by-products, oils and fats, starches, gourds, grain by-products, etc. Examples include, but are not limited to, proteins, inorganic materials, oils and fats, minerals, single-cell proteins, zooplankton, and leftovers.

본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.The composition for feed addition of the present invention may include a binder, an emulsifier, a preservative, etc. added to prevent quality deterioration, and an amino acid agent, vitamin agent, enzyme agent, probiotic agent, flavor agent, and non-protein agent added to feed to increase efficacy A nitrogen compound, a silicate agent, a buffer, a colorant, an extractant, an oligosaccharide, etc. may be included, and in addition, a feed mixture agent and the like may be additionally included.

또한, 본 발명은 박테리오파지 OPT-SC01을 포함하는, 음용수 첨가제를 제공한다.In addition, the present invention provides a drinking water additive comprising the bacteriophage OPT-SC01.

본 발명의 음용수 첨가제는 상기 박테리오파지 OPT-SC01 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 스타필로코커스균의 숫자를 감소시킬 수 있는 효과가 있다.The drinking water additive of the present invention may be used in a way that the bacteriophage OPT-SC01 or a composition comprising the same is separately prepared in the form of a drinking water additive and mixed with feed or drinking water, or directly added when preparing drinking water. There is an effect of continuously reducing the number of Staphylococcus bacteria by mixing and supplying the drinking water as described above.

본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.In the present invention, drinking water is not particularly limited, and drinking water commonly used in the art may be used.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 소독제를 제공한다.In addition, the present invention provides a disinfectant comprising the bacteriophage OPT-SC01.

스타필로코커스균, 예컨대 스타필로코커스 크로모게네스균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 OPT-SC01을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.Staphylococcus bacteria, such as Staphylococcus chromogenes, a disinfectant containing the bacteriophage OPT-SC01 of the present invention having a specific killing ability can be usefully used as a disinfectant for hospitals and public health to prevent hospital infection, and general It can be used as a household disinfectant, a disinfectant for food and cooking places and equipment, and for the disinfection of various growing products such as poultry farms and livestock houses, livestock, drinking water, litter, egg seats, transport vehicles, and tableware.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 세척제를 제공한다.In addition, the present invention provides a cleaning agent comprising the bacteriophage OPT-SC01.

본 발명의 박테리오파지 OPT-SC01은 스타필로코커스균, 예컨대 스타필로코커스 크로모게네스균에 특이적 사멸능을 가지므로, 상기 스타필로코커스균에 노출되었거나 노출될 가능성이 있는 가축의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.Since the bacteriophage OPT-SC01 of the present invention has a specific killing ability to Staphylococcus bacteria, such as Staphylococcus chromogenes, the skin surface or body angle of livestock exposed or likely to be exposed to the Staphylococcus bacteria. It can also be used for cleaning areas and the like.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 포함하는, 스타필로코커스 크로모게네스에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for preventing or treating infectious diseases caused by Staphylococcus chromogenes, including the bacteriophage OPT-SC01.

본 발명의 박테리오파지 OPT-SC01은 스타필로코커스균에 특이적인 사멸능을 가지므로, 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다. Since the bacteriophage OPT-SC01 of the present invention has a specific killing ability to Staphylococcus, it can be used in a pharmaceutical composition for preventing or treating infectious diseases caused by Staphylococcus.

본 발명에서, 스타필로코커스균, 특히 스타필로코커스 크로모게네스, 황색포도상구균, 표피포도상구균 및 스타필로코커스 자일로서스로 이루어진 군에서 선택된 1종 이상에 의한 감염성 질병은 유행성 또는 급성으로 발병하는 전염성 질환을 통칭하는 개념이다.In the present invention, Staphylococcus bacteria, particularly Staphylococcus chromogenes, Staphylococcus aureus, Staphylococcus epidermis, and Staphylococcus xylose, infectious diseases caused by at least one selected from the group consisting of an epidemic or acute onset It is a generic term for contagious diseases.

본 발명에서, 상기 감염성 질병은 스타필로코커스균 감염에 의한 염증, 농양 등 다양한 표피 감염, 식중독, 폐렴, 균혈증, 수막염, 패혈증, 폐화농증, 독성 쇼크 증후군(Toxic shock syndrome, TSS), 포도상구균 끓는 피부 증후군(Staphylococcal Scalded Skin Syndrome, SSSS) 등이 있으나, 상기 스타필로코커스균의 감염으로 인해 발병하는 감염성 질병이라면 이에 제한없이 적용 가능하다.In the present invention, the infectious disease is inflammation caused by Staphylococcus infection, various epidermal infections such as abscesses, food poisoning, pneumonia, bacteremia, meningitis, sepsis, septicemia, toxic shock syndrome (TSS), staphylococcus There is a boiling skin syndrome (Staphylococcal Scalded Skin Syndrome, SSSS) and the like, but it is applicable without limitation if it is an infectious disease caused by the infection of the Staphylococcus bacteria.

본 발명의 약학적 조성물은 1 × 103 내지 1 × 1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 × 106 내지 1 × 109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, PFU(plaque forming unit)는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.The pharmaceutical composition of the present invention contains 1 × 10 3 to 1 × 10 10 PFU/mL of bacteriophage, preferably 1 × 10 6 to 1 × 10 9 PFU/mL of bacteriophage. The term used in the present invention, PFU (plaque forming unit) is a numerical unit that bacteriophage forms a plaque.

본 발명의 용어 예방이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.As used herein, the term prophylaxis refers to any action that suppresses or delays the onset of a disease by administering the composition.

본 발명의 용어 치료란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.As used herein, the term treatment refers to any action in which the symptoms of the disease are improved or the disease is suppressed or alleviated and beneficially changed by administration of the composition.

본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.The pharmaceutical composition of the present invention may further include a pharmaceutically acceptable carrier.

본 발명에서, 용어 약학적으로 허용 가능한 담체란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.In the present invention, the term pharmaceutically acceptable carrier means a carrier or diluent that does not stimulate the organism and does not inhibit the biological activity and properties of the administered compound. Acceptable pharmaceutical carriers for compositions formulated as liquid solutions include sterile and biocompatible, saline, sterile water, Ringer's solution, buffered saline, albumin injection, dextrose solution, maltodextrin solution, glycerol, ethanol and One or more of these components may be mixed and used, and other conventional additives such as antioxidants, buffers, and bacteriostats may be added as needed. In addition, diluents, dispersants, surfactants, binders and lubricants may be additionally added to form an injectable formulation such as an aqueous solution, suspension, emulsion, etc., pills, capsules, granules or tablets.

본 발명의 약학적 조성물은 경구 투여 외에 비경구 투여, 비강분무, 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수도 있다.In addition to oral administration, the pharmaceutical composition of the present invention can be used by parenteral administration, nasal spraying, application or spraying to diseased sites, and in the case of parenteral administration, intravenous administration, intraperitoneal administration, intramuscular administration, subcutaneous administration Alternatively, it may be administered using local administration.

본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.Formulations for oral administration comprising the pharmaceutical composition of the present invention as an active ingredient include, for example, tablets, troches, lozenges, aqueous or oily suspensions, powders or granules, emulsions, hard or soft capsules, syrups or elixirs. It can be formulated as zero. For formulation into dosage forms such as tablets and capsules, a binder such as lactose, saccharose, sorbitol, mannitol, starch, amylopectin, cellulose or gelatin, an excipient such as dicalcium phosphate, a disintegrant such as corn starch or sweet potato starch, magnesium stearate , lubricating oil such as calcium stearate, sodium stearyl fumarate or polyethylene glycol wax, and in the case of capsule formulation, it may further contain a liquid carrier such as fatty oil in addition to the above-mentioned substances.

본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산 된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.Formulations for parenteral administration containing the pharmaceutical composition of the present invention as an active ingredient include an injection form such as subcutaneous injection, intravenous injection or intramuscular injection, a suppository injection method, or an aerosol for inhalation through the respiratory tract, etc. It can be formulated for spraying. In order to formulate an injectable formulation, the composition of the present invention may be mixed in water with a stabilizer or buffer to prepare a solution or suspension, and it may be formulated for unit administration in ampoules or vials. When formulated for spraying, such as an aerosol, a propellant or the like may be blended with an additive so that the water-dispersed concentrate or wet powder is dispersed.

본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.Appropriate application, spraying and dosage of the pharmaceutical composition of the present invention may be determined according to the formulation method, administration method, age, weight, sex, degree of disease symptoms, food, administration time, administration route, excretion rate, and the target animal and patient. It varies depending on factors such as response sensitivity, and an ordinary skilled doctor or veterinarian can easily determine and prescribe an effective dosage for the desired treatment.

또한, 본 발명은 상기 박테리오파지 OPT-SC01을 개체에 투여하는 단계를 포함하는, 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.In addition, the present invention provides a method for preventing or treating an infectious disease caused by Staphylococcus bacteria, comprising administering the bacteriophage OPT-SC01 to an individual.

본 발명에서, 상기 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료 방법은 스타필로코커스균에 의한 감염성 질병이 발생한 개체 또는 발생 위험이 있는 개체에 박테리오파지 OPT-SC01을 투여하는 단계를 포함한다. In the present invention, the method for preventing or treating an infectious disease caused by Staphylococcus bacteria comprises administering the bacteriophage OPT-SC01 to an individual having an infectious disease caused by Staphylococcus bacteria or an individual at risk of occurrence.

상기 스타필로코커스균에 의한 감염성 질병은 유방, 유두, 요도 등의 감염으로 인한 염증, 농양 등 다양한 표피 감염, 식중독, 폐렴, 균혈증, 수막염, 패혈증, 폐화농증, 독성 쇼크 증후군(Toxic shock syndrome, TSS), 포도상구균 끓는 피부 증후군(Staphylococcal Scalded Skin Syndrome, SSSS) 등이 있으나, 상기 스타필로코커스균의 감염으로 인해 발병하는 감염성 질병이라면 이에 제한없이 적용 가능하다.Infectious diseases caused by the Staphylococcus bacteria include various epidermal infections such as inflammation, abscesses, etc. caused by infections of the breast, nipple, urethra, food poisoning, pneumonia, bacteremia, meningitis, sepsis, pulmonary suppuration, toxic shock syndrome, TSS), Staphylococcal Scalded Skin Syndrome (SSSS), and the like, but is applicable without limitation if it is an infectious disease caused by the infection of the Staphylococcus bacteria.

본 발명에서, 용어 개체는 스타필로코커스균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다. In the present invention, the term individual refers to any individual that can develop an infectious disease caused by Staphylococcus bacteria, and includes mammals, livestock, or poultry, including humans, but is not limited thereto.

상기 용어 가축류는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.The term livestock is a concept that refers to useful animals that have been acclimatized and improved by humans and live together with humans, for example, including pigs, cattle, chickens, horses, ducks or dogs, etc. not.

상기 용어 가금류는 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.The term poultry is a concept that collectively refers to animals belonging to birds among livestock, and includes, for example, chickens, ducks, pheasants, quails, ostriches, geese or turkeys, but is not limited thereto.

본 발명의 방법에서 상기 박테리오파지 OPT-SC01 또는 조성물은 약학적 제제의 형태로 동물에게 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.In the method of the present invention, the bacteriophage OPT-SC01 or the composition may be administered to an animal in the form of a pharmaceutical formulation, or mixed with livestock feed or drinking water and administered through a method of feeding it.

본 발명의 방법에서 상기 박테리오파지 OPT-SC01 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.In the method of the present invention, the administration route of the bacteriophage OPT-SC01 or the composition may be administered through various routes, either oral or parenteral, as long as it can reach the target tissue, and specifically, oral, rectal, topical, intravenous, intraperitoneal It may be administered in a conventional manner via intramuscular, intramuscular, intraarterial, transdermal, intranasal, inhalation and the like.

본 발명의 방법에 투여되는 상기 박테리오파지 OPT-SC01의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.It is apparent to those skilled in the art that a suitable total daily amount of the bacteriophage OPT-SC01 administered in the method of the present invention can be determined by a treating physician within the scope of sound medical judgment. A specific therapeutically effective amount for a specific individual may be determined together with the type and degree of response to be achieved, the patient's age, weight, general health, sex and diet, administration time, administration route and secretion rate of the composition, treatment period, and specific composition. It is preferable to apply differently depending on various factors including drugs used or concurrently used and similar factors well known in the medical field.

본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.Terms not otherwise defined herein have the meanings commonly used in the art to which the present invention pertains.

이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail by way of Examples. However, the following examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following examples.

실시예 1: 신규한 박테리오파지의 분리 및 배양Example 1: Isolation and culture of novel bacteriophages

1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리1.1 Screening of Bacteriophages and Isolation of Single Bacteriophages

스타필로코커스 크로모게네스에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 충남 지역의 도계장 부근에서 시료를 채취하였으며, 박테리오파지 분리에 사용된 스타필로코커스 크로모게네스는 (주)옵티팜에서 채취한 야외 시료로부터 분리 동정된 것을 사용하였다.Staphylococcus chromogenes-specific bacteriophage was performed to screen and separate the plaque analysis. Samples were collected from the vicinity of the slaughterhouse in the Chungnam region where bacteriophages are expected to exist, and Staphylococcus chromogenes used for bacteriophage separation was isolated and identified from outdoor samples collected from Optipharm Co., Ltd. It was used.

구체적으로, 채취한 시료를 균질화한 후 스타필로코커스 크로모게네스와 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 3,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.2 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다.Specifically, the collected samples were homogenized and then cultured with Staphylococcus chromogenes at 35°C overnight with shaking. After centrifuging the culture solution at 3,000 rpm for 20 minutes, the supernatant was filtered using a filter having a pore size of 0.2 μm to obtain a sample filtrate.

전배양된 스타필로코커스 크로모게네스 150 μL를 취해서 멸균된 튜브에 넣고 3 mL의 TSB 탑 아가[대두카제인소화물(카제인 소화 솔리드(solids) 17 g, 대두소화솔리드 3 g, 덱스트로스 2.5 g, 소듐클로라이드 5 g, 디포타슘포스페이트 2.5 g/L) + 0.6% 아가]를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% TSB 아가 플레이트에 중층하였다. 이를 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.Take 150 μL of pre-cultured Staphylococcus chromogenes, put it in a sterile tube, and add 3 mL of TSB top agar [soy casein digested (17 g of casein digested solids), 3 g of soybean digested solid, 2.5 g of dextrose, sodium Chloride 5 g, dipotassium phosphate 2.5 g/L) + 0.6% agar] was added, mixed well, and layered on a 2% TSB agar plate prepared in advance. After leaving this at room temperature for 30 minutes, 10 μL of each of the sample filtrates was added dropwise, and then left at room temperature for 30 minutes, and then cultured at 35° C. for 24 hours to confirm the presence or absence of bacteriophages.

박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(스타필로코커스 크로모게네스) 배양액 150 μL에 혼합한 후 0.6% TSB 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% TSB 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액(NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl(pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간 동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% TSB 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 2% TSB 아가 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, 2% TSB 아가 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 3,000 rpm으로 20분간 원심분리하였다. 그 후, 상등액만 취했고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. A soft agar overlay (soft agar overlay) method was used to purely separate the bacteriophage from the sample confirming the presence of the bacteriophage. Dilute the sample confirmed to have bacteriophage appropriately with saline, take 100 µL of the sample dilution from each dilution stage, mix it with 150 µL of the target bacterial (Staphylococcus chromogenes) culture, and add 3 mL of 0.6% TSB top agar After adding and mixing well, it was layered on a pre-made 2% TSB agar plate, left to stand, and incubated at 35° C. for 24 hours. After confirming the plaques formed on each cultured plate, it was selected and suspended in 400 μL of SM buffer (NaCl 5.8 g/L; MgSO 4 7H 2 O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL). and left at room temperature for 4 hours. After mixing 100 μL of the bacteriophage solution with 500 μL of 0.6% TSB top agar and bacterial culture medium, the mixture was dispensed on a 150 mm diameter 2% TSB agar plate and layered, and then cultured at 35° C. until complete lysis. After completion of the culture, 15 mL of SM buffer was added to the 2% TSB agar plate, and the bacteriophage solution was recovered while slowly stirring at room temperature for 4 hours, followed by centrifugation at 3,000 rpm for 20 minutes. After that, only the supernatant was taken, and it was filtered with a 0.2 μm filter to recover the final bacteriophage solution.

1.2 박테리오파지의 대량 배양 및 정제1.2 Mass culture and purification of bacteriophages

상기 실시예 1.1에서 확인한 스타필로코커스 크로모게네스 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x107 PFU/mL로 희석한 후 전배양된 스타필로코커스 크로모게네스 1.0x109 CFU/mL과 혼합하고 MOI(Multiplicity of infection)를 0.01이 되도록 하여 35℃에서 100 rpm으로 18시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 OPT-SC01(Bacteriophage OPT-SC01)"로 명명하고, 2020년 9월 9일에 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 수탁번호 KFCC11863P를 부여받았다. 상기 박테리오파지 OPT-SC01은 'SC01'로 표시할 수 있으며, 수탁증에 표시된 'Staphylococcus chromogenes bacteriophage SC01’과 동일한 생물이다.In order to mass-culture the Staphylococcus chromogenes-specific bacteriophage identified in Example 1.1, the final bacteriophage culture solution recovered in 1.1 was diluted to 1.0x10 7 PFU/mL and then pre-cultured Staphylococcus chromogenes 1.0x10 It was mixed with 9 CFU/mL, and the MOI (Multiplicity of Infection) was set to 0.01, and incubated at 35°C at 100 rpm for 18 hours. After completion of the culture, the entire amount of the culture medium was centrifuged at 6,000 rpm for 30 minutes to obtain a supernatant, which was filtered with a 0.2 μm filter to recover the final bacteriophage culture. The isolated bacteriophage was named "Bacteriophage OPT-SC01", and deposited at the Korea Culture Center of Microorganisms (Seoul, Korea) on September 9, 2020, and accession number KFCC11863P has been granted The bacteriophage OPT-SC01 may be denoted as 'SC01', and is the same organism as 'Staphylococcus chromogenes bacteriophage SC01' indicated in deposits.

실시예 2: 박테리오파지 OPT-SC01의 전체 유전자 분석Example 2: Whole Gene Analysis of Bacteriophage OPT-SC01

박테리오파지 OPT-SC01의 전체 유전자를 분석하기 위해, 박테리오파지 OPT-SC01 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5%(w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL이 되도록 TE 완충액(Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII를 이용하여 유전자 시퀀싱을 시행하였다(마크로젠, 한국). In order to analyze the entire gene of the bacteriophage OPT-SC01, 20 mM EDTA, 50 μg/mL of proteinase K, 0.5% (w/v) SDS was added to the bacteriophage OPT-SC01 culture medium, and then at 50° C. for 1 hour. was political. After mixing with the same amount of phenol-chloroform-isopropyl alcohol (25:24:1), the supernatant was recovered by centrifugation at 12,000 rpm at room temperature for 10 minutes. The recovered supernatant was mixed with the same volume of phenol-chloroform-isopropyl alcohol (25:24:1), centrifuged at 12,000 rpm at room temperature for 10 minutes, and the supernatant was recovered, and 3M sodium acetate was added to the supernatant in a total volume of 10% (v/v) was added and then mixed. Two-fold volume of cold 95% ethanol was added thereto, mixed, and left at -20°C for 1 hour. After the reaction was completed, the precipitate was obtained by centrifugation at 12,000 rpm at 0° C. for 10 minutes, washed twice with cold 70% ethanol, and then the ethanol was completely removed to recover the DNA pellet. The recovered pellet was dissolved in TE buffer (Tris-EDTA, pH8.0) to a final volume of 50 μL, and then the DNA concentration was measured. For whole gene analysis, gene sequencing was performed using PacBioRSII (Macrogen, Korea).

시퀀싱 결과로 얻은 박테리오파지 OPT-SC01의 전체 유전자의 크기는 142,961 bp이며, GC함량은 31%, ORF(open reading frame)의 수는 214개임을 확인하였다. 분석한 박테리오파지 OPT-SC01의 전체 유전자 서열을 서열번호 1로 나타내었다.The total gene size of the bacteriophage OPT-SC01 obtained as a result of the sequencing was 142,961 bp, the GC content was 31%, and the number of ORF (open reading frames) was 214. The entire gene sequence of the analyzed bacteriophage OPT-SC01 was shown as SEQ ID NO: 1.

실시예 3: 박테리오파지 OPT-SC01의 형태학적 특성Example 3: Morphological Characteristics of Bacteriophage OPT-SC01

박테리오파지 OPT-SC01의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 Carbon-coated mica plate(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경(Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 1에 나타내었다.To investigate the morphological characteristics of the bacteriophage OPT-SC01, the culture medium was diluted in 0.01% gelatin solution and fixed with 2.5% glutaraldehyde solution. This was added dropwise to a carbon-coated mica plate (ca. 2.5 x 2.5 mm), adjusted for 10 minutes, and washed with sterile distilled water. This was put on a copper grid, dyed in 2% uranyl acetate for 30-60 seconds, dried, and then subjected to a transmission electron microscope (Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000 to 400,000). ) was observed. The results are shown in FIG. 1 .

도 1에 나타낸 바와 같이, 박테리오파지 OPT-SC01은 230-250 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였다.As shown in Figure 1, the bacteriophage OPT-SC01 has a size of 230-250 nm, has an icosahedral head and a contractile tail Myoviridae ( Myoviridae ) It was confirmed to belong to.

실시예 4: 박테리오파지 OPT-SC01의 다양한 세균에 대한 감염성 조사Example 4: Investigation of the infectivity of various bacteria of the bacteriophage OPT-SC01

포도상구균, 메티실린(methicillin) 내성 황색포도상구균 등의 다양한 세균에 대한 박테리오파지 OPT-SC01의 감염성을 조사하였다. The infectivity of the bacteriophage OPT-SC01 against various bacteria such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus was investigated.

우선, 소프트 아가 오버레이법을 통해, 박테리오파지 OPT-SC01의 스타필로코커스 크로모게네스 및 메티실린 내성 황색포도상구균에 대한 용균 활성을 확인하였고, 그 결과를 표 1에 나타내었다.First, through the soft agar overlay method, the lytic activity of the bacteriophage OPT-SC01 against Staphylococcus chromogenes and methicillin-resistant Staphylococcus aureus was confirmed, and the results are shown in Table 1.

대상세균명Target bacteria name 대상 세균수number of target bacteria 용균 활성이
확인된 수lytic activity
confirmed number 감수성 비율Susceptibility Ratio Staphylococcus chromogenesStaphylococcus chromogenes 24 균주24 strains 22 균주22 strains 92%92% Methicillin-Resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus 15 균주15 strains 12 균주12 strains 80%80%

상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 OPT-SC01은 스타필로코커스 크로모게네스 뿐만 아니라 메티실린 내성 황색포도상구균에 대해 높은 감수성을 보임을 확인하였다.As shown in Table 1, the bacteriophage OPT-SC01 of the present invention was confirmed to show high sensitivity to Staphylococcus chromogenes as well as methicillin-resistant Staphylococcus aureus.

또한, 박테리오파지 OPT-SC01이 다양한 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 아시아태평양 감염연구소, 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성(즉, 용균활성)을 확인하였다. 그 결과를 표 2에 나타내었다.In addition, in order to confirm whether the bacteriophage OPT-SC01 exhibits lytic activity against various bacteria, the soft agar overlay method was applied to the strains isolated and held by Optipharm Co. Through this, infectivity (ie, lytic activity) was confirmed. The results are shown in Table 2.

균주명strain name IDID 용균활성lytic activity Staphylococcus chromogenesStaphylococcus chromogenes Wild typewild type ++ Staphylococcus aureusStaphylococcus aureus KCCM 11640KCCM 11640 ++ Staphylococcus epidermidisStaphylococcus epidermidis KCTC 1917KCTC 1917 ++ Staphylococcus xylosusStaphylococcus xylosus KCCM 40887KCCM 40887 ++ Salmonella Typhimurium Salmonella Typhimurium Wild typewild type -- Salmonella Gallinarum Salmonella Gallinarum Wild typewild type -- Salmonella Enteritidis Salmonella Enteritidis KCCM 12021KCCM 12021 -- Salmonella Pullorum Salmonella Pullorum Wild typewild type -- Escherichia coliEscherichia coli Wild typewild type -- Escherichia coli O157:H7 Escherichia coli O157:H7 Wild typewild type -- Streptococcus suisStreptococcus suis KCTC 3557KCTC 3557 -- Yersinia enterocoliticaYersinia enterocolitica KCCM 41657KCCM 41657 -- Bacillus cereusBacillus cereus ATCC 11778ATCC 11778 -- Bacillus subtilisBacillus subtilis KCCM 11316KCCM 11316 -- Clostridium perfringensClostridium perfringens KCTC 3269KCTC 3269 -- Enterococcus faecalisEnterococcus faecalis Wild typewild type -- Enterococcus faeciumEnterococcus faecium Wild typewild type -- (+: 용균활성 있음, -; 용균활성 없음)(+: lytic activity, -; no lytic activity)

표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 OPT-SC01은 스타필로코커스 크로모게네스(Staphylococcus chromogenes), 황색포도상구균(Staphylococcus aureus), 표피포도상구균(Staphylococcus epidermidis) 및 스타필로코커스 자일로서스(Staphylococcus xylosus)에 대해 용균 활성을 나타내 스타필로코커스균에 대한 활성이 우수한 것을 확인하였다. 또한 박테리오파지 OPT-SC01은 Salmonella 종이나 Bacillus 종, Enterococcus 종 등 다른 세균에 대해서는 용균활성이 없는 것을 확인하였다.As shown in Table 2, the bacteriophage OPT-SC01 of the present invention is Staphylococcus chromogenes ), Staphylococcus aureus ), Staphylococcus epidermidis ) and Staphylococcus xylose ( Staphylococcus ) xylosus ), it was confirmed that the activity against Staphylococcus bacteria was excellent by showing lytic activity. In addition, it was confirmed that the bacteriophage OPT-SC01 had no lytic activity against other bacteria such as Salmonella species, Bacillus species, and Enterococcus species.

실시예 5: 박테리오파지 OPT-SC01의 세균 사멸 능력 조사Example 5: Investigation of bacterial killing ability of bacteriophage OPT-SC01

박테리오파지 OPT-SC01의 세균 사멸 능력을 조사하였다. The ability of the bacteriophage OPT-SC01 to kill bacteria was investigated.

박테리오파지 OPT-SC01의 스타필로코커스 크로모게네스에 대한 사멸 능력을 분석하기 위하여, 600 nm에서 흡광도가 약 0.5인 세균 배양액을 10 mL 준비하였다. 세균 배양액에 농도가 1.0x109 PFU/mL인 박테리오파지액을 1 mL 넣어 MOI 1로 접종한 실험군과 박테리오파지액을 넣지 않은 시료를 대조군으로 하여 실험을 진행하였다. 6시간 동안 배양하며 1시간 단위로 흡광도 600 nm에서 세균의 배양 상태를 관찰하였다. 박테리오파지 OPT-SC01의 세균 사멸 능력은 도 2에 나타내었다.In order to analyze the killing ability of the bacteriophage OPT-SC01 to Staphylococcus chromogenes, 10 mL of a bacterial culture having an absorbance of about 0.5 at 600 nm was prepared. The experiment was carried out using the experimental group inoculated with MOI 1 and the sample without the bacteriophage solution as a control group by adding 1 mL of a bacteriophage solution having a concentration of 1.0x10 9 PFU/mL to the bacterial culture medium. After culturing for 6 hours, the culture state of the bacteria was observed at an absorbance of 600 nm in units of 1 hour. Bacterial killing ability of the bacteriophage OPT-SC01 is shown in FIG. 2 .

도 2에 나타낸 바와 같이, 박테리오파지 OPT-SC01을 첨가하지 않은 대조군의 경우 6시간 후 600 nm에서 흡광도가 1.13으로 나타나 세균이 증식한 것을 확인하였다. 반면, 박테리오파지 OPT-SC01을 첨가한 실험군의 경우 6시간 경과했을 때 600 nm에서 흡광도가 0.39으로, 배양 시작단계(흡광도 0.5)보다 낮아진 것을 확인하였다. 상기 결과는 박테리오파지 OPT-SC01이 세균 사멸 능력이 우수하다는 것을 의미한다.As shown in FIG. 2, in the case of the control group that did not add the bacteriophage OPT-SC01, the absorbance at 600 nm after 6 hours was 1.13, confirming that the bacteria proliferated. On the other hand, in the case of the experimental group to which the bacteriophage OPT-SC01 was added, the absorbance at 600 nm was 0.39 when 6 hours elapsed, and it was confirmed that it was lower than the culture start stage (absorbance 0.5). The result means that the bacteriophage OPT-SC01 has excellent bacterial killing ability.

실시예 6: 박테리오파지 OPT-SC01의 pH 안정성 조사Example 6: Investigation of pH stability of bacteriophage OPT-SC01

박테리오파지 OPT-SC01의 pH에 대한 안정성을 확인하기 위하여, 다양한 pH 범위(pH 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL씩 분주하여 준비하였다. 박테리오파지 OPT-SC01 배양액을 1.0x109 PFU/mL가 되도록 준비한 다음 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계 희석한 후 소프트 아가 오버레이법을 통해 역가(titer)를 측정하였다. 측정 결과는 도 3에 나타내었다.In order to confirm the stability of the bacteriophage OPT-SC01 for pH, the number of bacteriophages in various pH ranges (pH 5, 6, 7, 8, 9, 10, 11) was measured. Sodium acetate buffer, sodium phosphate buffer, and Tris-HCl were used to adjust each pH, and then 990 μL was dispensed. The bacteriophage OPT-SC01 culture solution was prepared to be 1.0x10 9 PFU/mL, and then 10 μL of the culture solution was taken and added to each buffer prepared according to the pH, and left at room temperature for 2 hours. After standing, each reaction solution was diluted stepwise, and titer was measured through soft agar overlay method. The measurement results are shown in FIG. 3 .

도 3에 나타낸 바와 같이, 본 발명의 박테리오파지 OPT-SC01은 pH 5-7의 범위에서 2시간 동안 안정한 것을 확인하였다. 이를 통해 박테리오파지 OPT-SC01은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.As shown in Figure 3, it was confirmed that the bacteriophage OPT-SC01 of the present invention is stable for 2 hours in the range of pH 5-7. Through this, it can be seen that the bacteriophage OPT-SC01 is a bacteriophage with excellent pH stability.

실시예 7: 박테리오파지 OPT-SC01의 열 안정성 조사Example 7: Investigation of thermal stability of bacteriophage OPT-SC01

박테리오파지 OPT-SC01의 열 안정성을 확인하기 위하여, 40℃, 50℃ 및 60℃ 등 다양한 온도 범위에서 일정 시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 OPT-SC01 배양액을 1.0x109 PFU/mL가 되도록 희석한 후 배양액 5 mL을 멸균된 튜브에 분주하고 10분, 30분 및 1시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 역가를 측정하였다. 측정 결과는 도 4에 나타내었다.In order to confirm the thermal stability of the bacteriophage OPT-SC01, the number of bacteriophages was measured after leaving for a certain time in various temperature ranges such as 40 ℃, 50 ℃ and 60 ℃. More specifically, after diluting the bacteriophage OPT-SC01 culture solution to 1.0x10 9 PFU/mL, 5 mL of the culture solution was dispensed into a sterile tube and left at each temperature for 10 minutes, 30 minutes and 1 hour. After standing, each reaction solution was diluted stepwise, and titers were measured by soft agar overlay method. The measurement results are shown in FIG. 4 .

도 4에 나타낸 바와 같이, 본 발명의 박테리오파지 OPT-SC01은 40-50℃의 범위에서 60분까지 안정하며 60℃에서는 30분까지는 안정한 것을 확인하였다.As shown in Figure 4, the bacteriophage OPT-SC01 of the present invention is stable up to 60 minutes in the range of 40-50 ℃, it was confirmed that the stable up to 30 minutes at 60 ℃.

상기 실험으로부터 박테리오파지 OPT-SC01은 스타필로코커스균에 대한 특이성이 매우 높고, 스타필로코커스균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 OPT-SC01은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 OPT-SC01은 스타필로코커스균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.From the above experiment, it was confirmed that the bacteriophage OPT-SC01 has a very high specificity for Staphylococcus, and has the advantage of having excellent lytic activity and strong resistance to physicochemical stimuli by infecting and proliferating within the Staphylococcus bacteria. In addition, since the bacteriophage OPT-SC01 of the present invention does not infect other hosts other than bacteria such as humans, animals, plants, etc., it is possible to solve the problems of antibiotic-resistant bacteria due to the misuse of antibiotics, the residual problem of antibiotics in food, and the problems of a wide host range. There are advantages. Therefore, the bacteriophage OPT-SC01 of the present invention can be used in various fields for preventing or treating infectious diseases caused by Staphylococcus bacteria, antibiotic composition, composition for feed addition, feed, disinfectant, or cleaning agent.

이상, 본 발명내용의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적인 기술은 단지 바람직한 실시양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의해 정의된다고 할 것이다. Above, a specific part of the present invention has been described in detail, for those of ordinary skill in the art, it is clear that this specific description is only a preferred embodiment, and the scope of the present invention is not limited thereby. something to do. Accordingly, it is intended that the substantial scope of the present invention be defined by the appended claims and their equivalents.

한국미생물보존센터Korea Microorganism Conservation Center KFCC11863PKFCC11863P 2020090920200909

SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Staphylococcus specific bacteriophage OPT-SC01 and antibacterial composition comprising the same <130> 1-92P <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 142961 <212> DNA <213> OPT-SC01 <400> 1 ggagaaagtt atagtggaga atctttaaat gaaattatat atgatatgtt tgaataagga 60 gatgttatag atgtttaatg tatattatac agtttaccac aagcagagta tgaagacgat 120 tcaggataag ttagataggg atagtttaat atatttctta tatgagactt ggcataagga 180 tataagtaat atatacccaa cagactatac tacgtataaa acaaaattct gtatagatgt 240 agatatagat agactaattg aagcggttaa taaagaaggg atactactta ttaaccgtag 300 ttatgacgta gagttatagg atgttgacaa attgtaagta gtacatttgc ttttctacaa 360 gaattatggt ataataaaga aaaaaataga taggagttta ttatgaagtt aaagtttaac 420 aagacagata tagatattaa ttgtattgtt tataattctg tcattgaaga ttttggtata 480 gtagttggtc aaggtgaagg ttataatatt atgtatatga atagtaactc ggaaacttat 540 gatgagctac tagaaaattt cttaatatat aataaacctt taactttaga tgaacttatg 600 aaggataata aaacattacc taaggttaca atagaataat ttaggatact gaccgcttct 660 ttgagataag gaagcggtta tttatttggg ataaaaaccg taggataaat aggatagatt 720 ccgatttaca gtaggatgcg atagggttaa gatgttacga tgagataggg ttaaatactt 780 tgggataggg tttaggttat ttttagtata gttataagta ggtaacctga atattgatta 840 gttattccgg gtaataaaaa aatacctata ctgaatagag tataggttac aagtagttga 900 agatgattaa ggttaataat tgcttgccaa tttgaacaga ctatgcccgt tacatcttat 960 ataatattta tttgtttatc tattaggatg ttatatatag tgtaatagat actgtttcgt 1020 actagcgtac gacttagctt tttagaaaag ctaagaacaa aacagcttat gccaagttgt 1080 tgcttaacgc tacgctacaa caaccaggca acgcctgtaa tagttatcag taataaatta 1140 ctaacaacta attactttgt tgtttagatt atatcatatg tttatgagaa ttagatgaga 1200 attgggttac agtagtgtta catatttgta aatttattgt aaatattata taggttaagt 1260 tactccttat aatttgatta catataatag ggtaaataag acaagtagat ggtcactaat 1320 agggttaata atcagaagcg gatattgtct aagtagttgg ttatttaatt gataagaatt 1380 atcaataagt agcccctctt gattcgacct tgttataaaa gtcaaaaaag gtcaagtagc 1440 aacctcaaat tccccctagt ttatcccaac cgcttcacac ggtctatata tagacaatcg 1500 taataatatc agaccgcaaa aaaatacacc aagaatatta ttcctagttc attgtataat 1560 ttttttatag gatatttact taaacatata attattttgc ctaatttcta gtttcttcca 1620 tataaaacaa aaaataggct ttaaaacttt ttaaaaaaaa ttacattttc ttattgactt 1680 attaatcatt atcctttaat attagtagtg taataaataa cacgaaggga attgataata 1740 tggatataaa agaaattgca gatactatcc aggagctatg gcagatggac gggtacaagt 1800 gtttagaacc accgttattt gaaagcacag taaaccacac acgcacacac acagctttaa 1860 tcgttagcat taaaggtaat tacgaaacgg ttcagatgtt ccgcaaaacg cctttaatga 1920 gctttaaagg gcaatcacaa ccggctacaa tgttggtcaa tgtaattgat aacgtgatta 1980 taatcgttta tgaaaatacg gtttacgggg tgaaagataa agaaataaaa tttattgaag 2040 aaatttaaaa atagggcttg accttacatc taagatgtag taatataata gatgtaaggg 2100 atagcaacac accttaaaaa ctttttaaaa aagttaaaga aaagtgttga caccttaaaa 2160 gatacatgtt attattagta tagaagttaa gacaagccac ctagcaaata acgaaaaata 2220 aactaaaagg attgattaat tatgacaaaa aattatttat acaaagaaat tacaacggta 2280 caaaatgaaa gacttacagt tttcagaata cctaatgacg taaacgggaa ccctcgttat 2340 gttgtgcatt ttttagacct aaatattaag ttatcagatt atgacaacat aaacaaatta 2400 tatggcttta aaaaatatcg tgctcaatgg tatggtggcg gggtagtatt ccaaagctat 2460 aatatacaag atacattaaa ttgggcacta gataaagtta aagaaactga agcggttaaa 2520 taaaaccgct tctgaattaa ataaaaaaat tatataaaaa ggatatgata ttatgaataa 2580 aaaattaaat gaaattatta aaattgtact ttttggaact aatgaagaaa taaatagaat 2640 tgcactcaat tatgatgtaa ctttagatga attaaaaaaa ttaaatgatt attttcaaat 2700 tcaagatagt gatgcattaa gtgttgcaca agttatggat atagaaaatt attatccaaa 2760 ttctaatgta tctacaattg tatttcataa ttatattatt gaagtgttag aagatttaaa 2820 tacaatgtta gaagtataaa aaaattatac aatagcctag gattaaattc ctaggttttt 2880 ttatttattt aaatttatat aaaaaaatta tatagttgtg ttgataaaat ttgactttga 2940 ctaactttga ccaattgcac attaacgctt taacgtggta aagtgctaat gctttaatgc 3000 tttaccatgc taaaatctaa tttactttag cacattaacg tattaacgct ttaaaccgta 3060 acgctttaac gcactaaagg atttgctaca gatatgaagc ggacaacctt attcaatatt 3120 tattatataa aaaaattata ttaaatgact ttagagcccc tctctctccc caccttgtca 3180 tatttatagt ggaagggtta ggcgggttac cactgtttta ctttctatat atagtatact 3240 atgaataacc ataattgtca acacctttca gaaacttttt ttactttctt ttattattat 3300 ataaaaaaat tatagataaa aaagggctcc acttattatt atacaggaac ctacatagaa 3360 tgtcaatact tttcttcaaa aaagtttttt aaattaattt caataaatct attgacttat 3420 gttttattat cctttaatat ataggtatac taattcaaaa gggaattgtt caaatgatta 3480 ttttatggct agcttgtgaa attagacgtt tttacgataa aaagaaagag aaaaacctgg 3540 attatttatt ttaaaaaaat ctattgactt atctttactc ttgtagtaat attgatatat 3600 accaattagg aggacaacac aaaatgctaa aatttaaatt caaaaacaaa acaattaaat 3660 caactcaaaa aacagataac attattttac ttattatagg tggtttagtt gcaacagtca 3720 cacctaaact tgtaaattgg tttttactac tacaagataa catcaacatt tttattaaat 3780 aagtgttgac aacttagaaa taacgtgata ttattaagat aacaaataaa acaactgaaa 3840 aggatatgat gaaaatgaga aaaattacaa caactttaaa cttaatcgga atgagaaaca 3900 atgaaaggtt tacagaagag ttaaaaaact accgtcaaga tgttacattt ctaaaagcaa 3960 ataaaattgt aaaatattca aaataactat tgacaaccta aacattacat gttattatta 4020 atatatacca aatgagagga attgatttat tatgaatgaa caaacaataa tagaggtaac 4080 gtatttaatt tcaaaagata gctacacact caaaggaaaa tcacaaatac aagaggattt 4140 acaagacaat ttagaaactt tatatatgta tgaggatata caaacagaag aggaattgaa 4200 cgaccttata aagttgattc ctaataactt tgattatgtg atgaattatg tttgtgactt 4260 aatggaactt gattacaaat atttagaaat ctaaaataag gcttgacttc caagccttac 4320 catgatatta ttaagataac aaataagaga ggaattgatt aattatgaaa aacacattaa 4380 acaacgtaat tgaaacacta gaaagcaaag ggtacgaatt tgagtacgat gaaactgtta 4440 cagtattaga aatcacaagc cctagtggtg cttatgagga catcacacca agctttatac 4500 gtgacggaaa agttgaaagt ctttttatta ttcccgactt tttagatgaa gacctaggga 4560 acgtatgtat tgacttttat ggttatactt taaacttccc aaatgctaca gaattattaa 4620 atgaaattga aaatactttt aaataactgt tgacaatcta gaaacaacat gttattatta 4680 aggtacaagg taagggaagc ggtcaaccgc ttccaaccta gtaaaaaaag ttttaaaaaa 4740 ctattgacaa gtcacttagc cacatgatat aatgaattta acaaataaaa cagaaaagga 4800 attgattata atgaaattca tcaaaactat tgaaaactta ttaaacaaag ctgaaaacaa 4860 agggcaagca attttaaacg gtcgttactt tgacggatat agcaagggtg agcttgagga 4920 aaaatacgca attgagattg acggaaacaa attggttatg agacattggg gaacacaaac 4980 aattgagatt gacttaagcg ttaatgaaat tgtttcatac tatggagagt ctaacagtga 5040 tagagatagc cttaatacgc ttgtatattg cttagggatt gcaccaaact tccgttactt 5100 accaagcaaa gatttattca tttacgaaaa ttaattaaat aaagggcttg actttcaagc 5160 cctaccatgt tattattaaa ttgtaaggta atcaagcaca cggacaaaat aaaatgtaaa 5220 ggattgattg attatgaaaa tgacaacaga aaactacaat aaggtactaa aggtttacaa 5280 agaaaataag gtgcttatag caagccacaa agaacatctt aaagccaatg caacatacaa 5340 agacttaaac gtaagactag tgtttgatgt gttctattct caactattcc cactggaaga 5400 aagacgctta attgctcaaa atgacacgga taaagaattg cacgacaatc acctacaaac 5460 cgcattttta aaggcattaa atgaaatcgg attgaaagaa taaaaaaaat taaataaagg 5520 gcttgacttc caagccctac catgttatta ttaaattgta aggtaatcaa gcacaacgac 5580 aaataaactg aaaaggattg atgtaaaatg ttcaaattac aaaataaagt ggaaattatc 5640 gtaccaaaag aggataacaa cggtgttgag attgacgact tagcaatccg tgaagaatta 5700 gaaactatta ccaaaattgc gggaggttgt acgactacag acgttaaagg tcaatggtgg 5760 tcagacgatg aacaacgtat catgcaagat aataatataa actttgaatg gtactatgac 5820 aaggatatgc aagacgtgaa cgaccaacaa agcttattga aaggcttatc taccattgca 5880 agagtgttaa tacttcaata caatcaagaa ggcattagca ttaaagttaa tggtacacta 5940 tacattgtag atgaaagtga tttaaacttt ttatcttatg aattatatga cttaatgttt 6000 aagaattaaa taaaaaaatt atataaaccg cttcggatta aattcttgaa gcggttattt 6060 ttttttaaat tagggcttga caaatgtacg aaaaaatgag ataatgaagt gatgactttt 6120 tttcgtataa aaataatatt ctataaaaaa attatagata ttttagggct ccaagtccat 6180 tatatcaatt ttgctcccac ttgtcaatac ttaaattaat taaaaaagtt taataaatct 6240 attgacaatc ctttcaatcc atagtataat atagatataa ggttaaggag cccaagacca 6300 aagaaggggt ttcgggggga gtccgtcctt ttttataaaa aaataaccgt ccacctccat 6360 tatataataa ttcctacggt ttgtcaatac ttttgttaaa aataatttat ttaaaaaagt 6420 ttcataaatc tattgactta ctattaatta tactgtaata tatagagtgt aataaggaag 6480 cggaacactt aaaaaaagaa attaaaaaac ttttaaaaaa agtgttgaca ccttagcaca 6540 tagatggtaa tattaaggta gttaaaaaat acaaatcaga aaaggatatg atgaaaatga 6600 caaacacaat aaaaggattt ttacaaacag aggaagcaag cacagttaag gacgtagcaa 6660 cttacggagt acaaagcgga gcaattggca gattaatcta cacaaatgat gtagttaact 6720 tttttaatag atattatagt gatattgaag cggttgttac ggattactta gaaggcatca 6780 caggaatgca atattttgat ttattaaact atgaattaat gagagactta gaaaattatt 6840 caaatgtagc ctttgaagaa gaagacactt atttaaatat tacgttagac ctagcagaga 6900 aacgtgcaga agaagataac gaagattgga atgaactaac agaagatgaa aaacaagaac 6960 tttcactaga ttatatgaat gatgtggaga ttgatattct agaacttgat aaggttcagt 7020 ttgtatactt gtcagttgag attgtagcac aacaaatgca ggaagcataa gaacctgcag 7080 gaggcacaca gaggcacaca gagaagctta accgcttctc taatacaatt aattaggaga 7140 tgttgaagat gaacacaaga cgggtaaata aagccttaaa tgaagcaatt agattattag 7200 ataagcaaat atcagatacg cagaagacaa tgcaggagct aaacaaacaa ctagaacaac 7260 aaataaaagc taaacaggag ctaatgacat tagcggacgt tatgactggt gatgttgaag 7320 atgaacatta aagaagctca taacgttgtc agaagtgcaa agagcaaact cctgcaggag 7380 cagaagcata ttaataatgt ggtaattgat gaatacatca cagaggagct tcacagacgc 7440 acacagagaa gcggaaccat acagatgaac aataacattg cagaatatag taatgacgca 7500 tatggtagct taaaagagct tagagaagct tatgacctct cttctctatc tactggtgag 7560 attaaagaac taatcaaaac atttgtttaa aaaagtttta tcaaaacact ttacaactat 7620 ttaatttata tgctataatg aacttaacaa attaaaagaa aaggaattga tgaacatgaa 7680 agacttacaa gagagaaaaa gagaattgaa aacattacta tttaacttag ctattgagaa 7740 gaatagagca actgatgaac agttaagaga tgtattagaa caatcccatc aagaggtagc 7800 aaatcaatta agaaaagtta gaaaagaaat tgaaatttta gtcgaagaaa aagaaagaga 7860 attttggaac gatttagaat ttaatttatt agactaagag gagggcaaac gcccttcttt 7920 atttttatcc tattatataa tttttttata ttatacgggg gcaggggtaa aatgccactc 7980 aatgggggta ggtctatatg cccctacggt ctacccaggt acttattttt tggggaaaat 8040 tatgaaaata aatatttaaa agtcaacatc attataataa gtcaacatta taaccctata 8100 cttaaagtca acattataac cctactcaga aaatgcttaa taaaaaaatg taattaataa 8160 ccctaaagtc aacataccta aaataaaaaa agtaggggat aattaaatcc ctctacttat 8220 actaataact tataatctta actaagacag tttcttcatt tccacctgta ccattactac 8280 tatgacctct tattttatta tcttctatat aaataaactt agaacgtatt ccaccgcttc 8340 taactcccac taagaactta ataccaaaag aagcatacat actaggttgt gttttaggaa 8400 cataacaata attgacattg cctgatgaac cggaagtctc tttaaatact aatatatatc 8460 cattactaca ttctgataat ggttttgttg gaataatttc tttagaacca tccaatgtct 8520 ctgaacctga ccatacttca ttatagtctg tatcttcttt agcattatat aagtcatcta 8580 tttgttgttt ccattgttct aatgtttgac cgttattaag tttaatatta tctcctagtg 8640 ttataggata taaatgttcg aactgtccgg ctactttata attcatttgc attttatttt 8700 tatcccctta cctgtatatt taaataattt ttagttgggt atttaggtaa ccctgcacca 8760 taccaaaatg tatctcctag tggttctgcg ttgactgcca tacgttggag tattttttct 8820 ttaggttctt ggtacatttg tttatatagt atatagatac ctaatgtggc aggagtagat 8880 aatgaggttc ctgtgctacc tgttgagtag gaactgctaa tagctgttga gtttctagca 8940 gtagtggtag tgattatttt aacaccgcca ttagagaagt ttaatccttg accgatacaa 9000 cttgtagcgt atcttgtttt atccggatta atatttgcat tggcaatcgt gaaagggtat 9060 tttgcagggt acttagcggt atttgtagtt gtatctgttc gtggttgggt attacctgca 9120 ctacagaaaa tagctatacc attatttgaa gctatttcga atgctttttt acgagcttta 9180 gattctattc tactagagaa agaacagtta acagcatcca tcccattatc taccgcccaa 9240 ctcatacctg ctatttgact actccatgtt gtggagttaa tagcaccatt accgttatct 9300 atacggacag cataaatttt agcttcaggg gctataccta ttaaattacc atcaataccc 9360 tgggcgttaa ttacacctgc tacaagtgtt ccgtgtgagt tagctaagga gttatcccaa 9420 ggtaaagtag aatcgtaaac attaatacct gattctactt ttaggtttgt atgtttttgc 9480 acacctgtat ctagtatacc tatttttaat ccttgacctt tatacccttc tttatggaac 9540 tgttggatgt tcatcatatc gaaagcatat gatgtttggc ttgtttcata tatattaccc 9600 tctgatgatt ctacgtctgt gctctctgca ccatcttctt ctatactctc tactaggtca 9660 tgattcttta atttgaaagc atctgactct tccatatgag caaatacaat aactttcatg 9720 tggacttcta tattagaagc attgtattct tctagaaaat taaggtctga ctcttctttt 9780 aacacaataa gatatttatg cattagtctt tcacctcaaa ccatatatta ccttctgcag 9840 gttctgtact agatacaaca atgtatgcat ctgtaccatc cttaccgggt acaccctgaa 9900 ttccttgttc accttgttca cctttctcac cttggatacc ttgaattcct gggtcacctt 9960 tttctccttt agccccgtca gcaccgtctt gtcctgggac accttgtatt ccttgctcac 10020 cctgttcacc ttttaatgag tttagttggt cttctgtaaa atcttcatac ttgaagtctt 10080 ttccgggttc accttgaata cctggttcac ctttctcacc ttggatacct tggatacctt 10140 ggattcctgt gtcacctttt tctcctttaa gagatgataa gaattctgtt atggaacctt 10200 caaatccctc gttaactgcc aagtcatagg cactttctcc tgggtcacct ttttctccta 10260 tgtctccttt atcaccctta agagatgctc tttgctcttc agttaagtct tcgaaagtca 10320 ttgtaccatc ttgacctttt aatgattgta tttgttcttc tgttaaatct gagaatttta 10380 agggttctcc tttttctcca tgtaagctag ctaaatactc atctagctct ccttggaaac 10440 cttcttcgac agctaattca taactacttt taccgtcttt accatcttcc cctttttctc 10500 cctttaacac gttaagttgc tcttcactta aatcctcaaa actaaaagat tcaccatctt 10560 taccggctac acctgtttcc cctttttctc ctttttctcc ttttatagat tcaacccatt 10620 cttgttctgt tccttcaaat ccattatcta cagctatatc ataagctgtt tttgttttaa 10680 ctaatatatg gtctttaaaa taaaatgtta tttctttaaa agaggactca tgagttgtaa 10740 aaccgggtac ctctacttta tccgtctcgt atctctctgc ttcccaagaa acaaaaaatt 10800 cacccttagg gtaatgtgta tgaggtgcta agttaggtat aataactgaa cctacctctt 10860 cgtgtaattc tacattatag cctacagcta gtatatttcc ttgtctatca tatgctttta 10920 aatgtggcat ttataattct cctgttctat taaattctta cttataatat atcaaattga 10980 ataaagaagg gtattagtta ctctattatc taattcctgt tctatagtat tcatatgttc 11040 ccaaacctca atccaattta ctcttgtatc atcatagtaa aggtggtagt cctgtgggtt 11100 ttctaagtac tcttctaatt catcatagta taaaacttca aaagctgtgt cgtcaagtcc 11160 catttgaatc tttaggatat ctttataccc taactgttta ttaccacagt aagctgtgtc 11220 ctctaatctc ttctctagtt tattaaatag tgtttgtacg ccttgtaatt cattcataat 11280 tgattcctcc taattggtta tatacttagt ataaaggatg ggtattagaa tgtcaatagt 11340 tttatataaa aaaagagaaa gaatattatt cttcctctaa ggtgttatta gtaacttcta 11400 attcatgaat cgtaatcata tcttctctaa ataatggtac atcttctata ttatctttgt 11460 aatagtaagt gtatccatct tgaaggtatc cgcttcttct ctcttcataa ccatctgctt 11520 taatacgttt aattaagttc tctttatctg tatatacctt gttttctctg taagaatagt 11580 tatcttcata aggttcacaa ttatcatgtt ctacttgata tagtttcatt tatttatcct 11640 ccaataaatt tacttctaca atttcacgtt ctaaattaat attgtttggg tgactattaa 11700 atgcttcttg tgctttttct tttgcctcat tttcatcttt tgctgtaact tcatatttgg 11760 ggtgaaagaa aaacaatgga ctataaacga cttcaaatat tacttcatat ttattatttt 11820 tcatttattt atcctccttt tcgtaagacc attcaccgta ttctgcgtta aaatgggctg 11880 tgtctgttcc ctcatcttca tattctacac tataccatgc atcctcttct gtttctgcat 11940 ctatatatct tacttcttct gtagtaatag tacgttttac cttaaatctc cccatatgtt 12000 tttcctcctt agtattttcc tctagtattt gttttagggt ctgacaatct ttttggtcta 12060 aagtttgcca acgctctagg ttctgtaatt gatagtagag ttcatttaca atttcatcga 12120 aggcttctgc ttttttatag acttcctcta gttctgcttc tgctaatttc ctatcccttt 12180 taatttgttc tgatttagct actaatatat gggctttatt catttcttcg ataataaagt 12240 tcttatagtt tttcattgtg agtcctcctt atattcttta taacttttga taacaatatt 12300 acagatacct ctattaacag ctaaaaataa tagaaatgat agtagagtta taactgccct 12360 agtgtctcct gtaaagggta ataatttaaa tagtaaaata ctttctaaaa cacttgtagc 12420 tgtgataatt gtaaggtata agatagataa taagtaatcc tttaatttta gcttaacaaa 12480 aggtttttta ttatcctgtg tttttgctat accatatagg attataaacc atgctacagg 12540 tatgagttgc attataaagt cattatttat acctaatgcg tataaaccat aaatgatacc 12600 tgcggggata cctataatga atgctaagaa tacagataat ataattagca ttataggaag 12660 tgctacaagg aaccctaagc cttgttttga atactctaat gtattctttc ctaaggcttt 12720 aaagaatgtt ttattcatct tctacctcct tgtaatatac agtatctata tgagtaatat 12780 tatttttgaa ccatatggat ttatcacctt tgttagattc taaagattga gcaccattaa 12840 aaacaagacc ctcaataaaa gaatttaaat tagttttagt atctttttgt cgtacaataa 12900 tagaagaccc tgatacatca caaattctta taaaattaat atcttttgtt atttcttttt 12960 ttactttatt atttttaaac atcgttatta ttcctccttt tatttgtatt tattatagac 13020 acaatggact cgaacatctt ccattacttt acctaataga ttctgacctt tccaattact 13080 tttatctagt attttagggt catttgcttt aagacctaca ccccatatag tatcataagg 13140 tgatgcttct acgaaatctt tacgtaaatc tgtatcgagt atttcccgtt ttaagtgtgt 13200 agtcataaac ttatctttaa ccacttctac cataatgtca tatcttactt tattccattg 13260 ctcttcatta aaattacgaa ctttacgacc tagactttta gcatgtttcg gattcttagc 13320 atttaatatt tctcctgcta tctgccagtc tttaaaatat tgagccttac gccacataaa 13380 agcttgttct gaattattaa atgttcttcc tttatgttta aactttatag ggtaaaagtt 13440 agagtaaata tcttcctgac cccaaaacat aatatatctg cttgtttctc tcatttgtta 13500 ttatcctcct tataaatact tatctaaagt attttccatt ttgtctagct gttttctgtt 13560 ctctatcttt gcttggtttg atttatcaca ttcttcttta tttgattctt tgaactctcc 13620 cttatactcg atatactcat ctcttaattg aataagggtt ttaaagaaat catcataagt 13680 atttggtata cgtttactta catatcccct taaataacct gctaatagat aaagtttaat 13740 atcgtcatta ccgtaacctt caaaagagtt gagtttgaca ctaattgtga aaaagttttc 13800 aaatttaggt gtgttaaagt taaagtgtat agtatgacct ttactctcct tatcatgacg 13860 atattcaggc tctgaagcta taaaattatc tttattaagt ttttctatgt tttctttatt 13920 actgaatagt tctagtaatc tccctaaagt tactgtttcc atacttatct ctccttacct 13980 taaaaattta tttaatttat cttttttacg tttttctgtc tctaggttta ttaaatcttt 14040 ttctaatttt tctttatttt tttctttcca tatatcgtac aaatagtcta ggtactctgt 14100 aacggtatta aaatctttta ttttactacc tttactgtaa ctatcaccgt accctttttc 14160 tactactata taatcatccc caatagtagc attaatacta tcgttatctt tgatataata 14220 aatatgctct tcgggtgggg attgcatcat tacattgcca aagtaaacat actctaaggt 14280 atactcacca atttttttaa ctttacactc tctcatttca tcaaataaag ctaaaaacgt 14340 ttcataatcc ataaattaca tcctttctgc tgtataaaca aatatctaat cctccaattt 14400 aataagtggt aaatctatat ccctaaatac agcacctacg tcacatagca acatatcatt 14460 atgttcttct acttctccac taattgtagg tgtgtgaccg catacgtgaa taaaaccatc 14520 attacgtggt tggaaatctc ttgaccatag tagttggtat ttggtttggt ttttagcagg 14580 gttccaacta actccacctg aatgcgtaaa ctcatactta tcttgcttat atataacagc 14640 acagttatgc attagtattt taaactttct atagtcttca gactctttga attccctaat 14700 ttcttcaacg aatttatcga agtattctct ataaaactca ttttgattta actcaaagct 14760 ctttaatggt gttgtgtcaa taccgtacga ctctagtgtt tctatacagt accttgcaaa 14820 ccattcaaca ttatatatat ccagtttatc aatattttct atactatgcc aaaatgcatc 14880 atcatgattt cctaataacg gtataatgtc atcatcgttt gagactcttt caaaaacgta 14940 attaactacc tctctagatt tatcccctct atcaatataa tcccctaaaa atactataac 15000 atctccaggt tgtctttcct tgtctatctt attcataatt gttattagtt tttcatattc 15060 tccatgaata tcaggtacta catatatagc catttaatct cctccttatt gtatataact 15120 atcttatcat acttatttat aaatgtcaat aaaaaaacac ctattaatta aaataggtgt 15180 agaaagaact cctcgtatat taaagatata ctagagttct ctaattaatc attatgtaac 15240 gtgtgccttg aactcataaa ctcaggcact ccctaagttt tgggaatagt tttgtttact 15300 tgaggacata atatagcatc tgtagcctta tgtataacat accgactaac ctgttactgt 15360 ggtatgtgta ggctctagaa accctagttt ttatatcttc acctttcatt agatatatca 15420 ggtactttta atatgtattc tcccgtcact tatcggtttt tatttatact gtaaaacggg 15480 acgggtacca cgaaaaacag ccaacagagc tcccgtactt agattacggt taatattatt 15540 ttaagacaat tatatgagac cctctgttgt tgaaacgctc gtcactgcgt gtatgtacta 15600 taacagggag ctatataaga gtttacctca tatagctttg ccatagtaac tgaatataca 15660 gtggtttagc tgtcttatgg agttcctcca agctatacag aggaaatcag cttccttatg 15720 ttgcaactca tctaaccata aacttgagtt acacgccaag tgtctgatac ctaataatca 15780 agactcggta tctcaagccg ttactttata ctctatgaca ctccttctga atataaagct 15840 gtccgacttt tttcactctc aagttgctac ctgattttga gctatcccta tttggaaagt 15900 aggtacggtt cacctatact aatagtatag cataaataat acttaatgtc aagttaattt 15960 atcaatttaa tctattatta ctcctgaaca cctataagat ttttaagttt atctatgacc 16020 tcttcttctg tttggtaaga gaataccccg gtaatatgtt catagttacc tacaatttca 16080 taatcttgtg taccgtatct atctactaaa taagcattac ctaatacatt taaactaccg 16140 tctttataac taaaactaat attataatct actaaaaaat taataatttt tttcatttac 16200 ataacctctc ctattggata ctgacctaac attcttacac cctcttcatt ataaaaggta 16260 tactccacta caatgacatt catcttatct acgtatatag cctctatata aggtataata 16320 ttttcttctt tttgtatatg ttgccctacc atttcatata ataattctga gtgtattctt 16380 ttatctctca ttataaacct ccgtaagaaa cgctacagtt ttatctttta aagacttttc 16440 tactagttcc atagcatctt tatagtgttt tatattcgat tcattagact tcagtttatc 16500 ttttacctct tgaattaggg gttcaacttt agtaactaaa tcttttttat tttccatact 16560 tacattactt ctcttgttat ctaatacttc ttttggcata tacttaacct ttgcaaagtc 16620 tgtatagcta acatttaagt tatctaaatc atctaataaa tcattatagt attctaagtg 16680 attatagaac gtgtaaaact taacaaggtc tttacctgtt agttcctctc ttttcaatat 16740 agaattaata ttaccaataa cagaataagc tatagttttg aaattagctc tcacataagt 16800 cagaaatata aaatcatcat agaataaatc tagaacggtt ttattgaatc tagtattctt 16860 agcttgttct aattgagcac atagattaag aacattgtcg aaaccacttt ttagtattaa 16920 agaaataaat ctctctaccg catagtatct tgacacctct gtatgtttgc ttgctttttt 16980 actatttcta aaaatagtat ctgataaagg ttgaactact aggctcatat aatattcatc 17040 tgaatattca tccgatgttc cttgataggt acttccaaat tctattgtag ataataaaaa 17100 acttttttct aaatgcatta taacatcctc cttttacttg ttattataat attaacacat 17160 atgtttatta atgtcaaaca ttaaatatct tctgttgtat caatttcatc ttgcttatac 17220 ttaaaatatt cataaacttt aaataatata actcctaaag ttattaaccc taaaatatat 17280 ttcataacaa tcccccttaa taaccgtgtt tagttaccca tcctgctaaa gcatccatag 17340 ccatatcata ctcttcttca tttttaattc ttataatttt ctctatctct tcttttgctt 17400 gttcagaact aataaaatca atatcggtag cctctaggtt agttaattct aaattttctc 17460 taataaaatt cttttgacct ggtgttatag aattaactcg tacattttca tgatttaaaa 17520 attgatagaa gtccatatta ttcaccctct tttaaacagt ctgccatatc ttttaaagta 17580 ttaagtacat atttcaaatc tctatagtgg atgtcagaag aataaataat ggaatagggt 17640 gccatatcac tgtaatgtgc acaatcaaaa cctagtaccc tgtaatcacc ttcatgttca 17700 tcatacgtaa tacctccatg agaaaagctt tctatagcat taaacttctc ttcagttata 17760 tcagtaggta cattaatata accgttcaaa tgtcccattt cagggtgacg cttaaccgtt 17820 aattctatac ctttataatc tatatttaaa gttaaatcct ctcctaatat attatcctct 17880 ttggctatag ttttcataac atgttcaggt gctttttcaa acatagtatt tatacctcct 17940 tttatttata attctactat acactatttt ttatgttttg tcaacaaaaa aaggctacta 18000 attaaagtag cctaataaaa tattactttt ggtagtactt ccatttgaag taaccatttt 18060 tctgtgagaa ctcatagtga aaaccatcgt agtcaaattc aatattatag tctccatctt 18120 gaagcggttt tgaatttagt acaggactat tactctttgc taattctgct agaaactcat 18180 gatttacttt ttccataagg tttattcctc ctagttattc ttacagtatt aatatatcac 18240 aggtcttttt ctaggtcggt tttaaacttc tcttcatatg agctagcata agttacttca 18300 tatcctatta tcttagtata atctatacat agtaatttgt aattggattt tattttaatg 18360 tcttctgatt gttctatttt gttgataatt tcatctagtt catttgaaga atagtgttca 18420 ttatctacct ttattgtttt gccttgggta tagatatcaa tttcttgtat catcatttca 18480 tccttttgat tattcattat ttgattataa gtctctaaat catcaatgtt atctgtatcg 18540 gaacctttca ctaaccactc tcctctcttc ttaaggaggt catcaaactt ctcatgctct 18600 ttaattatct tttctacttc acttggtatt aaaacagctc tagcgtagtt tatatgccac 18660 atagacatat tatcaacaag ataattaacc attcttataa gttctttttc atttgccata 18720 taccaacccc cttatatcta atattaatat aagagaaaat cagacctatt aaaagtctga 18780 tttttcattt aattctaatc ttctattttt agtatgatgt atagacacct tatccccagt 18840 aagtaacgat aattctctag ctttttcttt agataaagtt attaacccat tgtagttttc 18900 tgttttacta ttatattcgt atactaggta tcctattttt tcttctaaat ctcgtaattc 18960 tccttcttta atcataagta gttttttata catcttgata tcctcagtaa gtttttctac 19020 attaccttta gataaagagt cataaacagc ctgtaaatta ccttcttcaa taagtttaaa 19080 gttatactct ccaatgatta attcttcctc agaagagtca agagttacta aaccgcttgt 19140 tgcataatcc ggtatacggt ttacaacaac accttcagtt actttgtcac ctaattcaat 19200 agtcccatct tcattttctt taaatttacg agcatcatat acttctactt tgtcacctat 19260 tctcaaatct tgagttaagt tatgttgacc tataattcta tccattactc aatctctcct 19320 ttattaatag ggtcttgtgt taagaacatt tctaaattct cttttgtaat agggaaccaa 19380 aaatactgac tgtccggagt tgaaactgtg taaaagtcct ctcctttatt tactacaata 19440 tttactggaa taaattcatc ctgcattaac cagtgagtaa caactatatc ataagaaccg 19500 tcaccactat aacttaagtc taatccatgt ttaaatgcta aatcttctaa atgttctaat 19560 aattcatttt ttgtatgaaa ttcttcttct ataggattat ctttaatagg gttaattagc 19620 tctttacaaa cgatatcgta taattcacca tctgtaactt cgtaattctt ttcaatcaat 19680 acatcttgaa ttttatcaat tgaatttgta actacttctg cgtattcttc ttctgtaaac 19740 ttacatttat ctaaatcaac atcggtaatt aattccgcaa tccatttatt taaaattgat 19800 accgccattg ttctagaaat aatattatca tatgtcatat ttatttaatc tccttgttta 19860 ggtgaatgtg gtcttctaat gaaaaatcta aaggcactac accatttctt ttagtatttt 19920 tttctttttt aagtataaca catactattg gaaaagtcaa gacagttgct attaacgtta 19980 ctgaaatttt atttaacttt ttcataacta ttctaactcc ttaagtttat tccttacttt 20040 atctttgtcg taattgtatt gtttttcagt ttctttgttc tcatcatctt cttttttagc 20100 atctatttct ctatatttag cttcttctac tttattgcca tccttcttat taggttcaga 20160 tttatctaaa tatgaattag ttttattttt accattttta tttttaccat ttttatttgt 20220 acgttttttc tttaaaaata accaaagtat tatcattata ataagtaaaa tgatgatgct 20280 caatactaca gcccaaatat tattagccat tataacctac ctccaaataa tttttttact 20340 tctcttaagt tttctgatga atcattattt atattaattc ctgtgctaga atcaaaaatt 20400 acagcattat caagtaagtt ttctttaagt tcattttcat aactagattt accggttaca 20460 ctaccataac caccctgtgt taaatcagtc atatcagatt caacttctaa tattctaaac 20520 gaaattctac gtaaaaatga tgggtttact aagtaaaacg atgatttaaa aacatttaat 20580 ctttgataag aatgttttat gttaacaaca aacccagtaa gtttaccagt acgacttgag 20640 tttgacagtt tacctaagta tagatttata ctataccctt ttgtttccaa tgtttggata 20700 gcacttaaca ttatagcacc tctataagca agattctcag ggtcttccat ccaacttata 20760 ctagaattat agaatacatc aatgactttc ttctctgcct taactctttg ttgagacatc 20820 atagagttag gtaaaccctt tatagcatta ggtacgtgag gttgataacc ttcaggagct 20880 ataaccggtt ttctttttac agatttatcc attctgaata atgcatctgt catcttttta 20940 agtttaacaa ccatgtcata agactctcta tcccctttaa ccattaagtt atatgcttca 21000 ttaaagctgt gagtgcctgt gaagtcgtag ctagctgtat ctgatgagtt gtctctacct 21060 gaaactctat tcttttttaa agcagaaaag aaatcaggta gaccatcata tttaattaca 21120 tttaattttg agttatctat taatcgtcta cccattgttt ttccccctat tctaatccta 21180 gtttatccat aatagtgtta aagtccattg aatcactaga tgaactttga gtttttcttg 21240 gttcttgttt aggctcttgt ttaggttctt gtttaatacc caaaagattt tttgttgctt 21300 ctgtgtatct gttatcttca ggtaaagaat taataaattg attaatctca tcttttggta 21360 cagacttgaa gatgatactt tctacaacaa actcgtcatc cattaccccg tctaatttac 21420 ttccattaat aattgcacgc attgaaaaga cataaggtaa tcctttttca tcattttcat 21480 atcttaattt ttgtacaaag tttactaagt cttcattact tgatagttgg tgttctacct 21540 tattatcgta atcaaattca acttgagcaa atcggtctaa tgtagcccca tctagttgct 21600 gtctaccaac gtaaatgtgg tctgctccag ttcccatagt gttacctgct gatactactc 21660 taaagtcttc atgtgctgtc acacgaccag ttgggaagtc aaagtattta tttgcaatag 21720 ctgagttaag aattaataat acctcaggga tagatgcatc catctcatct aagaagaata 21780 acccgccatt tgtaaatgct ttgtaaaatt gtgtttcatg gaatttacca tttgcatcaa 21840 taaaacctgt taatttaaac tcttgagtta ttgcgttact gaaataaaag tctaagtcta 21900 atgcttctgc tacttgctct aatacgtggt tcttacctga acctgctcca ccttttaaaa 21960 acactggaat gttctgatta actagtttta atatatcttg gtatctgtaa tggaagattc 22020 ctgagatatc cttaattgtt tttccttctt gttgtaattc aatcttaact ggtaaattat 22080 taagttgctc ttctacatat gattcaattt gttttttaac atcagtaaga attatttctc 22140 tactttcagt tcctgctttc tcaacaattg catctacaat tgcttgttcg taaggattag 22200 agttcttctc ccctagtttc tccgatagtt cctttgttgt ttccatttgt tgttctacca 22260 atctctctaa tctttcaata gtatcttgct ttgccatatt tatcattctc ctttaatttg 22320 ttatacattt attatattac aagtatttga atttgtcaac aactttctaa aacttttttt 22380 agttactaac aaaaaaatac cttacaccta taacttaaca tagggtaagg taattgtcaa 22440 cacttttttt aaaaatacat taacttaaaa aaatcgtcaa tatctttagt tccgtgtgta 22500 tccatatcat acataaacat acaattatat gtatggttat tcactatttc tagcatatta 22560 tgcatagaag ttgcattatt taattcatct aaatcaatag ttattgtaag ttcttgtcct 22620 tcataaagaa tgtttgctat ataatatttt ttaacacctt ccattgttcc atgggaagtt 22680 tcattatgat taagaacttc tatacctaat gacggtaaat actttgagaa atagtattta 22740 cagaaatata taaaattgtc tgttctttta gacacgagta ctgtctccat actttatgtt 22800 tctttctaat cttacataat atgttttaat cttttgaact tctttatcta ctgcatcttt 22860 tcttcctagt cttgtagtat attttacaat attaaatatc atagaatcaa caaaaccgtc 22920 ataagaaaag tgttcctcta agaaggaaat aacatcctta ctgcctttgt agtgctcagg 22980 taaatgtgca tctacttgta tatcatagta gtcttctaaa agacctatac tctcaccaag 23040 actagataaa gcataaccta aatcattaga gtcattagac cattctttag atactgataa 23100 cgcatcttct ataattgtta tttttaattt atctagataa tcttctactt gagcttgtgt 23160 tttcataaat tcttttgcgt tcatttaata ccctcctaaa ttatatataa aaaaacaccc 23220 tgctcggtta caagcaaggt gaaaaaggaa agatattatg gaagtgtact atctaagtac 23280 acctcataat ataacagttt tccttgccag ttattcctta ttttttaagg tcttcttcct 23340 taacaaatac tccattaata agctttcctt tacggtcttt tatctcatca tatgccatat 23400 caatgcactc ttcaatatca atatctaatt gtaagcaaag cactgttagt actacaaata 23460 tgtcccctac gctatctcgt gttacgtggt cattgctctt agcaattccg gaagctaatt 23520 ctcccgcttc ttctaataat tttaacatct gaccttcagg tttacctgtt tgtaaatttc 23580 tatcttgtgc ccactgttta ataagttcta ctttttccat tattctatat ctcctttaat 23640 ttctgtatct ttgataatta gattatcaga gtcacttgtt acatttaagt tatcttcaac 23700 tagttcatga aggttattag taatatcttc ttcataccga taacctacac gaacgtaagc 23760 tttcactctg acatctatat taacataatc ttcttggaat ttttccattt ctaacttcct 23820 ttattatatc atattgttaa tcttttgtca attaatctga gtaatttcct ttagcaagtt 23880 ggtacttttt gtgtaattct tcatataatt tttccatatc tttatattta cgtacatctt 23940 cttcaaaatg acttaaatac tctattagta ttttaacttc ttcaggctcc aaagttataa 24000 ctggttttac catttacgca acctccctat ttgttatgta ctaatcatat catagtagtt 24060 aatatttgtc aacaaaaaag aagaactttt taaagttctt ctaagtgagt ttcgtatata 24120 acctttcgaa ttttatttag tggttctaaa tctaaattct gaataagttt ttcgtacttt 24180 ctcgaatttt taaaattgat agtatttggc atagcaagag cctcatcaac gtctttagta 24240 tagcttacaa catctgaata gatatctact tcttttacat atagaccttg agttagactt 24300 ttaaatatta cctcattatg tgatactact tcttctttct tttctatgct catttgtaaa 24360 cctcctggtc tattctacac aaacaagtac gtactctaag ctagttaatg atactgattt 24420 aatattattt aattcttgca atttcttaat atctacatca tagtttttac ttatagtcca 24480 taatgtctct cctgctctta ctttatggta atacttattt ccctttttaa taaggtcatt 24540 caatattacc tacctccttg agtaataatt agcctgtaga taacatataa gtataagaac 24600 aaagtttaca aattcagtag ctataatatg aacataggta tgtgataaaa ccatacttga 24660 tatcaatgaa gctaatccta atccaataat aaggaataga aatctgtttg ttccttctgc 24720 acttttagtt ttatagaatg ttgttatctg agttacatac gcaaggataa tagtaatagt 24780 tgctatagtt tgtgttaaag ctgtaaagtc acttaataaa aatagtaaca atgagaacac 24840 aataataaaa ggtatagaga aataatcctt ttttctatat gaagctacta ataagcaaac 24900 aatacctagc gttaaattaa gaccaacgga tactacttgg aacattgaag catcagttaa 24960 tagtaaattg taaaaactaa tacctactgt agctacaatt aaataccaaa aataactact 25020 aactccttta acactatctg atttaactaa agctattaga cctggtatat aacctactgt 25080 aactaatata gcatataata tactcaggta atgtgataaa ttatccattt ttctctccta 25140 atttctctaa tctgttaagg acttcttccc aagagataac acccttacca tttgtaatat 25200 acattactaa accataagta tatgcattaa aggaataagg tattctatcc attgtatcat 25260 tcatatcgga tgtgttccaa cgaacatcat ctgagtatac taagcatatt ttatctacta 25320 ctttttgttt ctcatcaata attccttgta atgtgtagta ttcatcatta taagttccat 25380 ccgtattcat tgataattct tgcatctctt ctaattgact aataagattt ttagcttcac 25440 gtttcatttg gtaaatttga cctatttctg caaccgtacc tctaccccct gcatctgctg 25500 taggtaaatc aataacataa acatctgctt tttcaatagc ttgggtatcc tgctctacta 25560 ttctttctgc aagcttttct tttttagctg tcttttttga atttatatca tcatttgaac 25620 taggattata aacttgcaga ccttcaatac cctctatttc ttctttttgc tgtttacggt 25680 agtcaaacat agacttatgc aacatatctc ctgctaaata tacttgttta tagtttgtgt 25740 aatccattat tattctcctt ttatttaaaa ttactgagta attaatttat agtcctccga 25800 tgtaatcgtc tcctgcatct tgactgattt cgtactctct ttcaatatct tcttctgact 25860 taccttgtaa tccttccgct acgtcaccgt attcatcaaa taaaaaatcg aaaattccca 25920 ttataaaacc tcctcaaagt catagtctaa agcatctaac acttctgtta atagtaagtg 25980 ttcttggtct aaactaactg ttgttgctct taaatcattg tctaaaattt ctgcataata 26040 gtcttctaca aaatccattg taattgaatg tccttctgag tcctgaataa tataataccc 26100 ttgacttcca tctacttcta aaccttcact ctctaatacg tttataatat tattttgttt 26160 ttctgtaatc atactaatct ctcctttaag tttatacatt aattataagc tatatcttac 26220 ttactgtcaa ctatttttta tttattttct ttattttgtt gcactactgc taataaaata 26280 atacttacac ttgccaaaaa tgctaatacc actaaaccag gtaaatttag aactgttgat 26340 aagaataatg ctactgcact tataacataa actagaccgc tcaggaataa agttaataat 26400 acgattgtta taagttttac caaccagttg ttattaataa atactttagc taaataattc 26460 ataaaaaaat cctccttagt tattataaaa taagtatacc ataactaagg aggtttgtca 26520 acatattatt ttactatctt tttttactct actaccccat attgcttatt gtactctttt 26580 aatgttcctt tatcttctaa gtcttcaaat ctttcatcca tatcgtgatt tcttaaaata 26640 ctttctacca tttctactac tggatgtctt tgaacttctg taagattaag atggtcaaaa 26700 tattttttct ctttatcctt ttcatataat cctgataata atttatatag tccatttgtt 26760 tcggggttac gtaacgtttt gtcatcacat tgtgcaaaat tacctaaaaa tataaattta 26820 ctattgtttc ctgctcgtgt agctatagca cttattgtat ttatatctag attttgggct 26880 tcatcaataa taaagtaaac atcatttaat gaacgacctc ttatagattg aatggagtcg 26940 aaaaatactt ttttcttact ctcatcttgc ccttcaaata gtaaatagtc tttaatatta 27000 ctgttactat ccattacttc taaattatct aaaaaaggtg ctacgtaagg atataactta 27060 tcctgtgcgt caccaggtaa gaatccttgt gacataccta tctcaacctg taatctagtg 27120 taaattaatt ttttataatc tttatcttct attacttttt ctaaacctac tgcttgtgat 27180 attaaagact taccgcaacc actttgacct gaaataaagg tgaatggttt atcatttgta 27240 agatactgaa aagctaattt ttgttcttca ttttttgctg ttattccgaa atatgccata 27300 ttttaaagtt cccctatcta taaatagttt tactctcttt taatatagta ctttaaacaa 27360 gttctcctgt ttccgcacag aatccgaagc aatcacaatc tacgccacat tctgcttcct 27420 caggctcctc atcatttagt gtaaactcaa caattgcatt ctctgtatta cctttagata 27480 accctgtgta aatgacttca tcaaccatat cccaatcatt atctgctaag taatttacag 27540 tatctgctac tgactcgtta tcaggtaaga agacatcatc atctgtaaac ttaattaaaa 27600 tatctccttg tggtaataca tcattaatta aatcaatttc tgtttcttct tcaatagtaa 27660 atacagttcc ttctagtttt tcaggtgtag tatgtgttaa atgtttaaca tcttctcctg 27720 attcttcata aaatccgact gcattctttt ctttgttata ctttgcaata aacttaccat 27780 tatcactaac taaatattga ctgtttgcgt tataatcttc tgcatcttct aaagtcatag 27840 atggattatg gtctctaaca taataactaa ttttcataac atctgttgtt tgtactttct 27900 taccttttcc tttaattact gaattaattc tcttcataat attttctcct ttttctatat 27960 acctatagat ttttttgcta ggttatccgc atattcgttc cactcatctc cggtatgagc 28020 tttaactttt acaaaattaa tatctattga cttttgatac tctcttacca tcttaatata 28080 tgtctgactt aaaatatttc ttgctgacca ggtaccttca taccaatgaa tgagccctat 28140 atagtctata taaacaattg cttgtttata tcctaactta atagcctcct caataccgta 28200 acaacaagct aatatttcac ctgcaacatt attatacttt attaatcctg gtttgtcaac 28260 acttttacta atttctgata taatgttttc atctgtactt actaatacag ctcctgaacc 28320 taccttacct ttattatagg aagaactacc atcagtgtat atatttactc tatcctgcat 28380 atttataatc ctccatgaat tgagggtaat catagtcaga atagatatct cgacaaaatg 28440 ttatagaaat ataatcaaaa tcaaaacatt taaaacagtg ttcttttacc tcttctttat 28500 ttctagcaat tacattaaat ttaaaaccat ccgctattac agtaaataat cctcttttca 28560 taaaacaaat acctccacta agtttatttt aaattaataa ctaactcaat aaatgactta 28620 atcgttttgt ttttaccttc atcaatatct gagaagaagt taatcaaact atcatcctca 28680 tcaaataaat cttcaacatc atcaaattta tttaatatgt cagtaacact ataaccttct 28740 tctgatatat actcatgtaa gtcttcccca tcctctgaca gggacgcttc tattttaccg 28800 ttcttatttt caattaagta caaagtattt aataccttaa cagaatctat gactacacta 28860 taattactaa tagtaggata ttctacatag agtatttcta cattagtatt catataacta 28920 tcaattacag aattaactgt atctcttttt aattcagata cattatgttt tcgtatagta 28980 gggaattctt catcatactc tactaattct tttctatctg tattcaataa cttatctaaa 29040 gaagataata atactatttt atattgatta tcaggtagac tgtctgtaat ttccattatt 29100 gttaaaaacg tatcttcacc taaaactttg tttatgtctt gtaattcaaa tgaatctacc 29160 atttcaatag tatcatctat atcatctgta gacattaaaa aattaactag attattattc 29220 tccatcgtct tcctccaatt ccttaaataa ctctttacct ggtgtattta acgctttctc 29280 taacctcatt aaattagcac ttcttggttt ctttttacca tattcccaat aagatataag 29340 agagtaatga acacctattt cagaagctaa acttcttagt gtatgtcctt tttctactct 29400 aattttctga aggtttagag gcttactttc ctttttttca tccataacta tttctcctct 29460 acttttaaaa atttaaaatc cccggatgtc tttgaatttt ttagtatata ctcatgtgat 29520 ttgtctcttg cctctgcttt acttttagca taagtttcta tacaaaatac atgagatttt 29580 ttcaaatcag gtgactcata tctccaataa actttaaaaa gtagggtttc tttttttaga 29640 acattaatcc gaaaccatct tttaaatttg ttcatttatt atcctccttt atttatttgt 29700 taaactaatt atagcacagt taacttatga agtcaactat aatatacaaa aaaagactaa 29760 gaaattaatc ttagtcttaa tatattaata actattatgt gcgttgtggt atgcaagagc 29820 tcctgatgtt gaaccgtaac ggtcaatcat atattgtttt gcacctttag tttgttctgc 29880 tatagaacca ccactccatg atttacctaa tccttggaat aatccttgag ctcctgatga 29940 tgcattaaca gcattagggt tcattgtaga ttcacgcata gcaatttcaa tcattgcctc 30000 gtctccacct gcttgtctaa tctgttctgc tacagagact cctgtagaac tagttgattg 30060 tgtaggttgt ttagtttcct tttgaactgg tgctgatgtt gtttgtactt cttttttagt 30120 atcttgttta ttttgagtat caaattgtgc ttgttgttgg tctacttttt gttcaggtgt 30180 ttgttcttct ccggctaatc tagatactgt attatctact tgagttgaac ctgaatgata 30240 ttcgtaaccg aagttaccgt tataattata gaaatgataa gtaaattcac catcactaaa 30300 tgagaaatca tagttacctt cttgaattgg tttcgtatta acttctactg aatttgattt 30360 agcttgttct gctaatttat tatagtcaat ttcgtctgca ctagcttcgt ttgtagtaat 30420 acctccgaaa gtaatagctg tacctaatgc taatgttgca aaaattgttt tcttcataaa 30480 tttaaaactc cttaatattt tttaatatat tttttattac ataggtaatc ataacatata 30540 tttttaaata acgcaagtat aatatagcac tatttagtgt aatattatta aggttttgtt 30600 acaaacatta ccattgtcag ataattaaaa acaaaaaaaa agagaggtat taacctctct 30660 ctattattta cctgttacat ctacgatagt tccgtctcca ccaatttgga taggttgctt 30720 accgttccat ttttcaatta attgttgttg taaaacttca tctgttaatg attcacttct 30780 gatatcatta gctttctttt caccttttgc ttctacttct ttctttttag cattttgttc 30840 tgcaatttgt ttatcaactt tagtacgttc taactcttgg ttagctttaa cacggctgtc 30900 aattgctttt tgagtattct tatctgcttt aggactagat aatgcaatat cctcaattac 30960 aaatccttgt ttttctaagt tttcattcaa gctatctaaa gtatcttttt taatttctcc 31020 tgtcttaaca ccaaatgcat caattactga gtatttagat actgcttgac gtacattatc 31080 ttgtacccgt gaacgtaagt aacctttttc taattcttcg atatctgcac taccaaaacg 31140 attaaataaa gctacagctt tagttgcatc tactttatat gaaacatcaa tatccatttg 31200 taaattctta ccatctgaag ttgccacatt taaatcttta tatttatgtg tttgtgtttt 31260 agtaggatat ttatttactt tatcaaaagg tgctgttaag tgccaaccag gtgatttggt 31320 ttcttccttt acaccattta ctgaatatac aacaccaaca tgaccttgtg gaacctttgt 31380 gatacacatt aataaaataa taaatcctat aattgctaaa aaccctaata ctcctgaaat 31440 aactactgac ttcctcattt acatttctcc tttttctatc tcttttatta aactatttaa 31500 agctttttct tcttggtcta tttcttgttt atcggctcta gttacaattg attgtctacg 31560 gtcatttaag aattgttttt tatattttac atattgttct aaaccgtact catctaatgt 31620 accttgccta actaattccc tgtattgttt tcttatgtta cttttcttct ccttcattga 31680 aagaaaatca aatacgtaac ttataccaaa acctacaagg actagaaaaa caataaaaat 31740 agcaaagtat gttaaaaata atgccatgta attcctcctt tatttgatta catatataac 31800 tatacactat gtattggatt ttgtcaacac ttctttgcaa aaaaaaatag acggatttta 31860 tatccgtcta aattcctatt ctacttgaat atcccccagg caactccagg tacatgtgaa 31920 ggtggaacgc cttgacaagt tctaacaggg caatatactc tgttaccatt gtaagcatta 31980 taacctatcc aaatgtgtcc tgcttggata caaacttcgt catatacaat tgtagctcct 32040 gccggtaagt tacctcctac cggagcattt aagaatggag aacctattct agttattata 32100 ggttggttac cattaacgaa tgttgccgat tccggtttgt accaagttcc gtattggttc 32160 tttttccaag aacctacaac tggtctagtt gccggtgtac ttgcactact tgttttatct 32220 tttttaacta cagtagaact tgaagttccg ttactcatgt agtttttaat ttgtttaatg 32280 aaataatctt taagtttatt cattattgct tgtgatggtc ttccttgtgt tactggattg 32340 aatcctgtat gaagaaccat tgaacggtga gggcacgcag taggaacgaa ttccatgtgt 32400 aatcttacac ttttacggtt aggtgtaata ccccactctt taaatttttc tgctgtaaat 32460 tggaatactg cttgttcgtt tttaaggaat tgagcatcac tagcactcat tgattgacag 32520 acctcaatgc ctgcaaatct aaagttacct gagttagctc ctgttccatc acccgtatgg 32580 aaggcaattt gattcttagc atctattgct tcccaaatat aaccttctga accgtagtaa 32640 tgtgcaatac cgttaaagta tctttgttgt cctgcattag ctaaagagtt ttcatattgt 32700 tgtcctgaag aacgacccgc atcgttgtgt atccttatgt ttcactagtt cgttaatcta 32760 gctctaggta tttcctagca ccctcattac aaggcgtgag cagactattt ctctctatct 32820 cttagagata gttcttcttt cgagttcact tgaaccctac gaggaggcaa tcctctagtc 32880 gttgaacatt ctccttatga tttttctatc acttaggagt agtgatgcta aacaaaccaa 32940 tccttgaact tgttaaacct tcataaagtc ttttcagctt tattgtggta tcaaggctct 33000 aaggttcttc aaagcaattt atgtttttag tacatatacc tcacgatata tgcagtgcgt 33060 tttacaccat tccttcaggt tttttaccac gtttatccat agtataattg atatggttct 33120 tagaaacttt tagttttgct ttctttttag gtgcaggtgt tttacttgca cttttcttag 33180 tagctgtttc ttttttaaca gtagttcctg cttttacagg tatttcaatg aaatgagtta 33240 atccgtaata attatctaca cgttttgtag gttttttatt agcgtaaccg ttccagtttt 33300 gctctaaaat agtaaatgtt gaagtattac ctccatcata tacaatccct atatgacccc 33360 actgtgcata gctaccggat gtaaatactg caatccaacc ttttttaggt actgtagaag 33420 gtttattttc atgtatttta aatccagtac cataactttg tttgatttgg tctttagcat 33480 taccccaagt tctaacttta ttatctgtta accataatac atagtctgta ataaggtctt 33540 ggcattgagc gtgataatcg tttatatttt atttaatgcc tttctgtgta ataatttctt 33600 attacatttg tttaacatta aatagtttct tttttagaaa ccttatggat ttcccataag 33660 actagactat atcttaatta attgacaaaa caccattttt cttttattat atcaagaagg 33720 tttttatttg tcaattaatt ttttgcactg tcttacaatt gtaagctctt agtcgttgaa 33780 gcttctacta cttttaccat agtagcttgc ctgcggatta cccaatcttt atctttttta 33840 ctataccaaa cacattactg tttgcccttg gttatgtcac cataccaagt tagtagataa 33900 agctctaagg gcttccccgt caattcacaa aattttacat gaactatttt attaatccat 33960 ccgcatcaat tgctcctgcc tccattacac caaatgaagg gtcataactt gttgctttct 34020 taactctata aggactatct actgttcctt ttgcatatgc gtctaaacgt ttatttattt 34080 ctgcttgcgt cttagccatt acttaacttc ctcctccgca aatactttac cgtgttcttc 34140 ggtatcttct tcgtcttgag aaggtgctga accgccatca atttcatctt caatagcagg 34200 tacttcatca ctatcatctg tatcaggctc tgcattattt tcgtagctgt ctagttcaaa 34260 agtactagct gtgcttgcat ctgcttgcca ttgaacaaat tcattagggt ctttactatc 34320 acgaggtttt gtatagtctg tttgaacaat atcactatct ttaatacctt tagtattgtt 34380 atcaacaata atacctaaac ctgctaataa tgttagtata gaacctacga tattgacacc 34440 ttgctcaatt tgagctgaat agtctaaacc aaaagcacct gtaatttgat tagcaaatac 34500 tgctactgct gatataattg ctacccaaaa tgttttactc ttagttcgtg tgctaaggtt 34560 tattcctcca acaactgtag gttgtttagt ttcattagcc attaaaaaac cgacctttct 34620 attatattta tttctaacaa taatataaca gtaggtcggt catgtttaac tatattaatt 34680 taacacttac tcgtttattt gatttaattt tttaataact tctgacattt gtttattgtc 34740 taaatcttct aatttagttt caggtaatag ctctaattta tcccaaactt cttctttatt 34800 agaaacttta ttattgatta ttgctttacc tactaaactc tctgtatagt ataattgttt 34860 tgctgatgcc atttatatct ctccttttaa atatgtaaag taatttagtt tacgacccat 34920 acgagactcg aactcgtact ctctgccgtg acagggcagt gtgttaacca gttacaccaa 34980 tgagccaaaa taaatgctat accctaacct taccttaatg tatagcaggt tttctcttag 35040 gttcgaagca acgattatta ccactcataa caactatata ttaagtgaaa ggaggtgaaa 35100 tgaacaaagc gtgataattg gtacctaaga aggaaatatg tataatctac aaggagtaag 35160 ttattggttc ataaaggagt gtgaacaata aatacatgaa agagtgaaaa tatactcctt 35220 gtagattctt ttttaattat caatcaaagg aggaaactga taattgttaa taataaacta 35280 taaagaggaa aatatttata gtcacattct gatataatgc aactaaatat ccaagcataa 35340 ctcgtctcac cgagaaccta cctataagac ctgttattaa gttaatcact acgcttgact 35400 ctattaagga gctaccttaa gtccatctca cgcaatccaa aaggataatg tgatactaac 35460 atattagtta gtaactttca catggtcgaa gaaataatct gtttggttaa ctaattattt 35520 ttaccaaata tatctttcga aactgtagat ttatgctact catactgata acctctatta 35580 tctaacacat ttctgtgctc caactacagg aagttgttac agcgtatctt cctaggattc 35640 cgctaagacc ctaaaaagaa attaaactct agctgttatc atactctaca gaccttataa 35700 gtaagtacca agtataccaa tcgtattaaa caatactaat gacgacccat cttaccgaaa 35760 taactccgat aagttttgat tcgtttgatt atcttgtacc ttatgactac caaatcatta 35820 ttcagtcact atgctcagat atttagttgt attatttata tattaactat aacataattt 35880 ttactacttg tcaagttaat ttcaaaaaaa ttatagaagt agggacacgt acctacttcc 35940 atttaactta cataaggatg tttacattgt tattgtttga actggaaaac aatgtaagaa 36000 aaaacagtga tgtgtaaggt atttgtttta ttgttaatta cattatagca tatactgata 36060 cctttgtcaa gttaatttaa tacttttttt aaaatattat ttatcttttg ttaattcttc 36120 ttgaatagca tcccatcttc tttctgcttc actacgatta tcttctacat gttttgtagt 36180 tttacaacat ttgatacaat atatatcttt gatatgacct tcttctcttt tatttgctct 36240 ttttcttggt actttgaata cattaccaca ttctttacat attaaacttg agtaaaacat 36300 tttttgtctt ttcataatta atcaattcct tttctttaaa tataatttaa gtatagcagg 36360 tgttgaacag taagtcaaca cctttatttt aattctttaa tttacaatcc tgagaaggga 36420 ctactataag aatctaaatc tatagaatat ctgtcttcta tatttttaat agcattaaac 36480 atcttttcta catactccac atcagtacct atagtatcta gtatatttga attttctatt 36540 gtactaatag gtacattgtt actttccatc tttttaagtc ttctagtatg cttagattta 36600 atatttatat tttgagaata taacatttct ctatatactt cgttccatgc tttaccaaaa 36660 ttaggataca taacactgct taatttaggt gctaattgtc taactctttt attagcttct 36720 tgcttccaat cattattttc aggtttctct tgaagaaact ctaatttatt ttctaactct 36780 attatttcat attctgcatt ttttagcttg ttattttctg ctcgtagttc ttgaactaat 36840 ttgttaagtc tttcggattc tgtataatat ttaaccattt cgttcctagc ttcctgagga 36900 ttatctataa tagctttagc aaaatcatca ttaacataga tgccatattt tctgatgtca 36960 ggtaaaactt ccttagtaac ccattttcta aattttttag ctgattctaa ccttgatgag 37020 aatactagac tgtataaacc ggactcattt atcagaatag gtttttgttc ccttccaatg 37080 gagtcacgaa ttgttacccc atctattttt tcatctaagt ctacatggtc tattaatgct 37140 tttcttgtgt ttgagtatcc taatacttct gcaacatctt tacctacaaa ataaggattt 37200 ccttgatatt ctacaactct tacttctttt ccttgatagt ttaattcttt taataaatcc 37260 attttaaatc attccttttc ttgttttatt tgatagttta actatatact atattgataa 37320 ataagtcaac agttttttaa aaataattta aattattttg aagaatcctt taataccaag 37380 ggttacaaga gaaaaagtac gtatttagaa aataaggagt actcctatta tatataatta 37440 tattctgata taagtaatta ataatattaa atatataatt ataattaaca agaacagaaa 37500 aattactatt ctgagtaata atttatattt atctaaagta aaatcccttt atatcagtac 37560 ttacagaaga aaaagtacgt atttagaaaa taaggagtac tcctattata gttatatata 37620 tatatattta ttacttatta ttaattacta atatataata tataattaac aatgttaaga 37680 agtcaacaat aagacaaata aaaaagtgac tacttaaagt cactcaataa ttaaaataca 37740 attttaaaag attctattct tttcgggtta atataaactt gaggtgaagc attattactc 37800 tcagtaaata ctttaattga tacagaatca acaccactaa gcatataatc tatgtcttgc 37860 ctactataac tcttttcatc agtagatact aaaaaatact tagcaccact tgacattgtt 37920 atttcaatat gttttgacat ctacaatctc tcctatgcaa atttgttaaa gacaaaggat 37980 aatatagctc ctagaacaag taaaagaacc ttctcagtag tatccttttt cttggtatcc 38040 ttagtttttg tactttcagc aagttctgaa atcttttcat caagtctttc taattggacg 38100 taaattgctg attgtttttc actattgaca gctacatctt tatctatact aactatcatt 38160 tttcttagtt cagctacctc aacttctaaa tctctgaaag ttcctctatc tatataatta 38220 ccttcttgta tcttagactt aatagaatct acttgagaaa caaggttgtt tatttcctta 38280 tccaactaga atcacctcta aggtctaacc gtttcagact cagaatgggt atcataattt 38340 tctaagaaat cattgataat ctccatataa ttatccgtaa cgacttttcc gtaagatgtt 38400 tttgtatcaa tttcaaacct aagcttaccg aaactttgga ggtctaactc ttttattaca 38460 atatttgggt catcagaagg aaggtaataa tagtcgaagt atataattga gccatttatt 38520 aatactctgt ctattctata gacatggaaa tagcgtctgt ctcttttaaa atgagctagt 38580 gcatctttaa actctaactt aaggatatcc ttatatttag tcaaagtggt aacctcctta 38640 ctattaattt ttaattttac ttattttgtg gtataatagt tatgataaaa gcagttatta 38700 taattatatt gaggataatg ataataatta ttttttctga gaaaataagc caaagactaa 38760 aaacagataa actatagata gctgatagat atactatatt aatagttatc ttacttttat 38820 cttttctata gatagaataa cctaaagaag ctgtaacacc actaagtata aaataataga 38880 aacaaaaaag aggtatagac acaaaaaaag atacgataat cattgctaaa cacctatttc 38940 ttttgaccta ttatttctag aacttttaga ttacaccact aatataacat taaaagacgg 39000 tcataaaagt caattgttag attaataata taataaaaaa agacaatagg aggttaaagt 39060 ggttgaataa taacatagct atattcatat tcaaaacttt ggttattatt atattcttac 39120 tactaatttt gtctgttatt aattccttgt cccttattta ctcaataaga ccgagtgtag 39180 ttatgacata ctttaccttt ggtggtatta tttcttatgt cgcacttact ataatagata 39240 agttcttact taagaaagaa gaccccctac ctgaatatgt tcttaaacag gtagagataa 39300 atgataaaga aataagaata atcaagaaaa tcatagaaag taattacggt ataacagcag 39360 aagagataaa agttagagct aaagcccaaa gaagagtaga ggaagatagt aaaagggaag 39420 attacgatga aaacgaagaa agaaattaaa gaacaaagga aagaacttaa ggacggtgct 39480 acaactgttt ctttagtaaa aaaaggagat aagagaatag ctagtcctag tagaatttgt 39540 agtctatgcg gtcagcagtt atcaggtatg aattacacta aagggaaagc attagcaaaa 39600 gttaatcatt ttcatttaca gtattctaag tatatttatt ttgatatctg tgctgatatc 39660 aacaattgct ataaaaattt aagaaaacga ggtgaaatgg attgagtgca gaaaatatta 39720 gagatataat taacaagaaa aagttagaag aagaggatac aagaaaatat atagctgatg 39780 gatttatgaa tggtatcggt aaattaatgt atgaattcaa taaaaaagta gataataaag 39840 aaatagaagt taaagaccct aacgatttat ataaactatt tgtgatattc tctcaaatgc 39900 agaatatggt taatgaaact tctgaaggtg gagcaatccc tcaactatct agacctcaac 39960 aagaattatt tgaagagatt acaacagaag atagtaacgg agagtctaca gtagacttac 40020 aaaaaatatc agaaatgtca gcggaagata ttacagaaat gatttccgag aaggaaagag 40080 taatgaatga ggaaaattct gagacattct aaggagaaag atataaatgg atggaaaaga 40140 actaattaag atagcacaag aaacatttca aacagaaaaa ataacaagag aacaggtaga 40200 ccatataatc aatatgttaa acccttctac ctatatgctt aagtatcata ctttgagggg 40260 acaccctatt acttttagta ttcctaatag ggatagaagt aaagcacagg ctcatagacc 40320 ttggcaagtc cgtaaacata ctatgcggac tataaacctt ttctaaaatt gggaaatcct 40380 aacaagtaaa gttgaggaca atcaattgct aaatcgtaac taagataaat attttaatta 40440 cgtaaatgcc taacgactaa atttccaagt aagcaataaa atggtattgt gtagaattgg 40500 aagagaggga aaccgtaacg aaagggactt ttacgcctaa ctgtaaaagt atgatatagt 40560 ctaatcccct aataaatatc gggaaaccga gggtattaaa tgatagtaaa cgacactcat 40620 ccaaataaag cagtaataaa aagcagacag cttggtttga gtgagatgag tgtaatggaa 40680 atggttcatt ttgcagatat gtatagttat aaatcaccta aatgtcttta caccttcccg 40740 accaacgagc agatgaaaaa atttgttcaa tctaggttaa atcctgtatt agagaaaaga 40800 tatttcactg atatagttaa ttgggataaa gattccttag ggtataagca aataagaaat 40860 tctagcttat tttttagaac aagcagtaaa cctgggacag tagaaggtgt tgatatagac 40920 tttcttgcaa tggatgaata tgagcgtgta aatagccttg ctgagtcttc tgcactagag 40980 tccatgtcaa gttctacatt ccaaatagta cgtaggttct caacaccttc agcacctgga 41040 atcggtattc ataaacttta ccaacagtca gaccaatggt attatgcaca cgtttgtcag 41100 cactgtgatt accataatga gatgaaatat gcaccgtacg atgaaaataa cttgatggaa 41160 agcggtaatt tattattagt taatcctgat ggtatagatg aaacagcaaa aacagtccaa 41220 gatggtactt accagtatgt atgtcaaaaa tgcggtaaac ctctagatag atggtataat 41280 ggagtatggg aatgtcgtta ccctgataga accaaaaata actcaggtat tagaggttac 41340 tatattagtc agatgaacgc tgtatggatt tctgcagacc aacttgttga aaaagaaatg 41400 aacacagaat caaaacaagc cttttataat tattcattgg gtaaataggt agccccttta 41460 tatagtaatg tgtatcgaat aactctgtta aacagggaaa ctctaagtgc ttaaataagc 41520 atatgacaat cctgtgctaa attcttaatt taattgttga caaaataata atgtatgata 41580 taattaaatt aggataaatg cctaacgact aaatttctag gtagctatat aaacggatat 41640 agtgagaact agataaaaac taataatttt ttaaacttaa tatagaagaa aggaggaaat 41700 acaaaatggc aagaagaatg acaacagagg atttcaaaca aagaataaca gcagagacag 41760 atggagaata tatagttctt agtgaatatg ttaataacca aactaaggtg ttaatacagc 41820 ataaatcgaa caactgtaac aatcatcagt attgggtaaa acctaaagga atactttcag 41880 ggacaagatg ccctgcctgt aataataaga aaaaaggtaa aaaacctaag acaaccgaac 41940 aattcaaaaa agaattaaag gatatggttg gagatgaata cacactagta ggtaaatatg 42000 caggagtatc caataagatt actttactac atcatgaatg tggtaaagag tgggaagtta 42060 cccctaacgc ttttatttct ggaggctcaa gatgttggta ctgtaatata aaaagacata 42120 acctaagtca aagaaagaca catgaagtat ttgtccaaga ggttagagac aggtacgata 42180 atgattacaa agtactagga acttatatta actcaaaaaa taaagtacta gttagacata 42240 aatgcggaac agaatgggaa ataaaaccta atcatttact gtcaagagac atgtgcccta 42300 catgtaagat gtctgtcgga gaaaaacatg tagaaaaata tcttaatagt agagatatta 42360 agtttgaacc tcagaagaag ttttctgact tagtatataa aagaaacttg tcctatgact 42420 tttacttacc tgaattaaac atcttaatag aatataatgg agctcaacac tacatgccaa 42480 tagagagttt tggtggtaaa gaggcatatg agcaacaagt tataaaagat gatattaaaa 42540 gaaagtatgc aaatgaaaat gggtacaagt taattgaagt taagtatact gagaagtact 42600 ataatactat agcaagatat ttagataaaa aattattagt gtaaagcaga gagcccttaa 42660 cctaaactaa gggttatgat atagtctaaa ccgtaaataa atactaggaa actagcggta 42720 gtaattgatg ccttttgaag atgttaaaat gcgtgtttta gaagaagatg tatttgaaaa 42780 taaatcacct gttgcagaaa aacaattaat gagacgagat agatatacac atatttctgt 42840 aggtatagat tggggtaata ctcattggat ttctattcat ggagttttac ctgacggtaa 42900 aaaagattta attagattat tttctgtcaa gaaaatgtct agacctgata tggtagaggc 42960 agatttagaa aaaatcattt gggaaatatc taagtacgac cccgacatta taattgcaga 43020 taacggtgac tcaggtaata atgttttaaa actaattaat cattttgggg aagacaaagt 43080 ttttggatgt acttataaat cttctcctaa atccacagga cagttaagac ctgaatttaa 43140 tgaaaataaa aatacggtta cagtagataa attaatgcag aacaaattat atattcaagg 43200 tttaaaaact aagaatatta gaatgtacca agaagtagac gatgatttaa gaactttctt 43260 aaaacattgg caaaatgtat taattatgga tgaagaagat gagaaaacag aggaaatgag 43320 acaggtaatt aaacgtaaag gtgacgacca ttgggctcaa gcttctgtat attctaatat 43380 tggattaaca agaatacaag aacttcttaa agaaggaaac ggtacaagct ttggttctac 43440 atttgtttct actgattata atcaagaagg aaataaacaa ttctactttg atgaatagag 43500 gtgaaataga cttgacaaat aaattatttt atggtacaat tagtaatgaa gaaattaata 43560 aaagtgtatt gaatttgtta ttgggtgagg aattatcttt agactatgtt tctaaaaata 43620 gtgattcctt agatgttaaa tacgaacatg tttataaatc tctaggattc gataatttct 43680 ttgattgttt tttatatgct aatagagaac ctgaaatagt ccacaaaggt ggagataaaa 43740 atcttggtag gctaaataag gttaaacgta ctgttattcg taatggtaaa gaaatgcaaa 43800 tgacagttta cgaagacggt aataaagata atgatagtaa tgaaaaacaa gaaggaaaag 43860 aagaagttag tagaagtgca gtaggagcaa gagctatttc gaatggtgaa gaaggaaagg 43920 taaaccctaa aaaggtagca aattcattat ctagtttaag taaaaaaggt gtcgatgtat 43980 cacatgtcag tacaaactca ccattgtaca aagagtttgt tgatgataac ggggatacat 44040 taggaattac atcttttaaa agaactgaaa atgatataat cttagactct tatgcaagtt 44100 cacctgattc agatggtgta ggagcaagag ctattatgga attattacgt ttaagtatta 44160 aggaaaataa aaatgcagtt gtgtatgata tagaattgcc cgaagctata gagtatttaa 44220 aaactttagg atttaaacct aataaagatg gatacatctt aagaaaaaaa gatgtaaaac 44280 aattcttagg tgattatagt gattttattt agcactataa tcatctattc tattgtattc 44340 atattatata ttataataaa attaatttat ataaagtcta atatgagtag aatagataac 44400 acaactgaat tattaaagat attacaggaa gatattgaag gtaagataaa aaaggaagga 44460 agaaataaat gactttagaa gaaaataatt taacattaga agaatcaata actccactta 44520 gtaaagaaga gaaagaagat agtattaaag aatttagtag cttattatgt gaaatggtaa 44580 atagactata caagtcttat aacgtattta gacaagaccc tatggatgaa acgcaacgac 44640 tagatggttc tctaatggta tttcaaagta gattaaatga cccattaaca ggagatttac 44700 atgataagat gtataagctt gctttttcaa aacgcattga tatttttgaa gctaacaagc 44760 aattcagaaa agatgtagaa ttaggtaaag caattgagct aggtgatgta gctattatag 44820 atacagcatt aagtaacatt ctttcaggta atgagttcca aggaagtatt tcttttatgc 44880 ttagaaaaga ctttgaagaa aaagaaaaaa ttagaaaaga agaagaagaa aaacttaata 44940 acttataaaa aggaagaatt atgagactat ataaaaaaag aggtatcata attgaaaaag 45000 aaaccacaag gcaatgagat aatcataacc ataattacgg ttatgatagc agtatttgta 45060 gtcatcatga ccatattttt taataaatat caagatgcta aggaagataa agatagatat 45120 cagagaatag ttgagattta taaaaaagca gatgataata atggtgagac taaaaagaaa 45180 tatgtaaaaa gattaaatga cgctgaagaa gagcttaaga aagttaaaaa agaaacaaat 45240 tataagggtt ataacgagaa gtcaaaaaaa gaaagacaaa aggaagataa aaaaactaga 45300 gataaaatat atgatgtaac cggtgacgat gatttaatat tagtaaaaaa taatattgag 45360 tttagtgata aagtagacaa tcctgaaata cttattagtg aagatggggt tggtacgata 45420 actgttccta cagacagtgg ttatgaaaaa caaacagtag gttctattat tactagtgta 45480 ttaggttccc cttatctatc tcagaatcca cctagtacag atagtttagg tattattgat 45540 agtaatgttt atccaaacac agcagatagt gtaccaacag ataaccctac tataacaaat 45600 ccagttaacc cagtggatat attacctcct acggataatc cttcagttgg cactgtacca 45660 acggataatc ctattataac aaacccagtt gaacctgaca caccttcaga tatattacct 45720 cctactgata atccttcagt tcctatatta cctggaaata ccgaagacaa taacgcagga 45780 aatacaggaa atacaggaaa tacagataat ccaaatccac cacctccagg atatacagat 45840 gaggatggtg gaaaaggttc aggtggagga ggtaatattg aaccaccacc aacagaagaa 45900 ccttcagata atggtaatac aggagacaat gaagaagaag tgactcctga acctgaacct 45960 actccttctg aacctgagac tgagaaacct aacgaaaaac ctgatgaggg aaatgaagaa 46020 gaagtaaccc ctgaaccatc agaaccaaca gataaccctg atgaaaatgg ggcagaggaa 46080 actgaaccat ctgaacctga aacaccatct gagccggacg ataaagcgga cgaagaagat 46140 acaaatgaag gtacatcaga ggatgagcag actacagaac aaccggacga taatactaca 46200 gataacgaag ataaaattga agaggagtaa ttactcctct ttttttgcta tattaaataa 46260 gagataaata taaaaaaatt gaacattacg gtggtgaaaa ctttggtagg aatgaatgtt 46320 ataacgtcac tatcagtagt atttacctgt ttaagtcttt taactttaat gatttttgtt 46380 cacagtaagt tctccagtaa aaacgttttt gttttgtatg taatttatgc tataataggt 46440 ataggcacat acatagtttt aactatgttt caaacaacat ctgtacttat taaaaatgat 46500 gtaatagatt ccatagaaaa tactgaacat tatattggat tcaatgaccc tctaattata 46560 tttactataa gttttatagg tgcaatactt ggaggaatgt ggtacaagat gatgaaaatt 46620 attaaaacga gtaactttaa aaataaaaaa agacggtgaa taggttgata ttctctaaag 46680 ataaaaaatg ggatgaagca aaagatttca tcaaaggtca aggtatgcaa gataattgga 46740 tagagattgt agattattat agacagatag gtggaaaaca cgtagctgtt tttattgctt 46800 taaacaaagt aaaatatatg attctagaag caacaaaaga caataaagta atactagtag 46860 ataaagataa taatatacta ttagaagatt atgatattgt tatggaaagt aaaaagatgt 46920 tttactacat tgaagaacca ttcgaggtta aaataaatat ccctcaacat attagaaatg 46980 taacttataa taacactgtt gtattaacta cagtaagagg gagtagaggt gactagtaat 47040 tggcagattt atttaagcaa ttcagattag gtaagagcta cagtaataat agtactattg 47100 ctcaggttcc tattgatgaa ggattacaag ctaacattaa aaaaatagag caagacaata 47160 aagagtatca agacttaact aagtctttat acggacagca acaggcttat gcagagccct 47220 ttatagaaat gatggatact aatcctgagt ttagagacaa gagaagttac atgaagaatg 47280 aacataattt acatgatgtt ttgaaaaagt ttggtaacaa tcctattctt aatgctatca 47340 tacttacacg ttcaaatcaa gtagctatgt attgtcaacc tgcaagatac tcagagaaag 47400 gtttaggttt tgaggtaaga ctaagagacc tagatgcaga gccaggtaga aaagaaaaag 47460 aagaaatgaa acgcatagaa gactttattg ttaatactgg taaagataaa gatgtagaca 47520 gagactcgtt ccaaactttc tgtaagaaaa ttgttagaga tacttatata tatgaccagg 47580 ttaactttga aaaagtattt agtaagaaca ataaaactag attagagaaa ttcatagcag 47640 tagacccttc tactattttt tatgcaacag ataaaaaagg taaaattatt aagggtggca 47700 agagatttgt tcaggtagta gataaaagag tagtggctag ttttacttct agagaattgg 47760 ctatgggtat aagaaaccct agaactgaat tatcttcttc cggatacgga ttatcagaag 47820 tagagatagc tatgaaagaa tttattgcct acaataatac tgaatcattt aatgatagat 47880 ttttctcaca cggtggtact actagaggta ttttacaaat acgttcagac caacaacaat 47940 cacaacatgc attagagaat tttaagcgtg aatggaaatc aagtttatca ggtatcaatg 48000 gttcatggca aattccggtg gtaatggcag acgatattaa atttgttaat atgaccccta 48060 ctgctaatga tatgcaattc gagaaatggt taaactatct tattaatatt atatctgctt 48120 tgtatggtat tgaccctgca gaaattggtt tccctaatag aggaggagct acaggttcta 48180 aaggtggctc tactttaaat gaggctgacc caggtaaaaa acaacaacaa tctcaaaata 48240 aaggtttaca gcctttactt agatttatcg aagatttagt taatagacat ataatatctg 48300 aatatggaga taaatacact ttccaatttg ttggtggaga tactaagagt gctacagata 48360 aacttaatat ccttaaactt gaaactcaaa tattcaaaac agtaaacgag gctagagaag 48420 agcaaggtaa gaaacctatt gaaggtggag acattatctt agatgcttca ttcttacaag 48480 caacagctca attacaacaa gagaaacaat atgatgatgg taaacaaaaa gaacgtttac 48540 aaatgatgat gagtttacta gagggagata atgacgattc cgaagacagt caatcggcag 48600 attctagtaa tgaagctaaa gaaataggaa cagatgcaca gataaaaggt gacgataatg 48660 tatatcgtac tcaaacatct aataaaggtc aaggaagaaa aggagaaaaa tcttctgact 48720 ttaaacatta attaataagc ctagaataaa tctaggcttt atttattttt ttgttaattt 48780 aattttgata aatgtaataa ctatggtata ctatatgtaa ttgatattaa tacatataaa 48840 atattaatat ttcacttaca agttattatt gttatattat taacgtaaaa gtaaataaaa 48900 taacaagtgg aggtgtagac acctttggaa gaaataaaat ttaatgcttt tgtacctatg 48960 gatttgaaga aatctgtatc aacagcttct gatactaatg agtattctat cgtttcagga 49020 tgggctagta ctccaagtat ggatttacag aatgacatcg ttaatcctaa aggaatagat 49080 atagagtatt ttaaatcaca agggtacatt aattatgagc atcaaagtga taaagttgta 49140 ggtataccta cagagaattg ctatgtggat atagaaaaag gtttatttat tgaagcaaag 49200 ttatggaaga atgatgaaaa tgttattaag atgcttgatt tagctgagaa attagaaaaa 49260 tcaggtagcg gaagacgttt aggtttttct attgaaggtg cagttaaaaa acgtaatgtg 49320 aatgacaata gagttattga tgaagttatg ataacaggag ttgcattagt taaaaatcct 49380 gctaatcctg aagcaacatg ggaaagcttt atgaaatcat ttttaactgg tcacggtaca 49440 tcacctgaca ctcaagttga tgcaggagct ttaagaaaag aagaaatagc atctagcatt 49500 acaaatttag cctacgtcac taagattaaa gatttaaaag agtttaatga tgtatggaat 49560 ggcgttgttg aagatttgag taaatctaat agtatgggat atgaggaatc agtccttacg 49620 ttacaactag ctaaaggttt atctcgtaaa gatgcagaac tagcagtaat ggatataaac 49680 aaacaaaaac tagaataggt aaggagaata cattctatga gtaaagaaat gcaaaatatt 49740 ttagaagagt atgataagtt aaatgctcaa gaggcagttt ctaaatctgt agatgaagat 49800 gaaaaaaata cagtagaagc tactgaagaa caagtagcag aaacaactga agaacctgct 49860 aaagaacctg aaaaggttac tgaagaagat gctaaagaag cacaagagca gggtgaaaaa 49920 gttgaatctg aagaagagtc tgaaggtaaa gaagatgaag aagttgagaa atcagctaaa 49980 gaatctaaag accctgtaga ccataaagac actaaaacag aagataaaga caacgagaaa 50040 cgtaagaaca aaaaagataa agattctgat gaagattctg aagaagataa agatggagaa 50100 gattctaagg attctaaaga taagaaagaa gataagaagg aaaaaacttc taaatcaatt 50160 tctgatgaag atatcttagt aggctttaaa actatcttga aatcttttga aaatttaaat 50220 gaagagaaaa aagagtttgc tactaaatct gaagttgaag aattaagtaa atcaattaaa 50280 gaattatcag ctaaacttga cactcaagat acagaagatg tttctaaatc agtagataat 50340 ggtgaagatg aagctgtaga aaaatcagtt acatctacaa atggagaaca agaaaaagta 50400 gaaggttatg tttctaagtc agtagatgcc gaagaacaag ctgaaactgg agaagcaaaa 50460 acagaagaat ctgaagaagt acaagaagat aatacattca aaggtttaag tcaagaagaa 50520 cgaactaagt tcatggattc ttataaagca caagctaaag accctagagc atctaagcac 50580 gatttacaat cagcttatca atcttacttg aacattaaca ctgaccctac taatgcatca 50640 gagaaagata ttaaaactgt aaaagacttt gcacaaattt aattaacgca caaagttgtg 50700 ttatattata cggtgtaact aaagaatata aatagggtac attttactgt accctacata 50760 aaataaaaag aacacaaatg aaaggtgata aatttatatg actatcgaaa agaacctgtc 50820 agacgttcaa caaaagtacg ctgaccaatt ccaagaagac gtagtaaagt cattccaaac 50880 tggttatgga atcactcctg atacacaaat tgacgcagga gctttacgta gagaaatttt 50940 agatgaccaa atcacaatgt taacatggac taatgaagat ttaatcttct accgtgatat 51000 ttcacgccgt cctgctcaat ctacagtagt aaaatacgac caatatttac gtcatggtaa 51060 cgtaggtcac tctcgtttcg ttaaagaaat cggagtagca ccagtatctg acccaaatat 51120 ccgtcaaaaa acagtatcaa tgaaatacgt ttctgatact aaaaacatgt caattgcatc 51180 aggtttagta aataacattg ctgacccatc acaaatcctt acagaagatg ctatcgcagt 51240 tgttgcaaaa acaattgagt gggcttcatt ctacggtgac gcttcattaa cttctgaagt 51300 tgaaggtgaa ggtttagagt ttgatggttt agctaaatta attgacaaaa ataacgtaat 51360 taacgctaaa ggtgaacaat taacagaacg ccacttaaat gaggcggcgg tacgtatcgg 51420 taaaggcttc ggtacagcta cagatgctta catgcctatc ggtgtacatg cagacttcgt 51480 taactcaatc ttaggtcgtc aaatgcaatt aatgcaagac aacagcggta acgttaatac 51540 tggttacagt gtaaatggtt tctactcatc tcgtggattc attaaattac atggctctac 51600 agtaatggaa aatgaattaa tcttagatga atcattacaa ccattaccaa atgctccaca 51660 acctgctaaa gttacagcta cagttgaaac taagcaaaaa ggtgcttttg aagatgaaga 51720 agaccgtgca ggattatcat ataaagtagt agttaactca gatgacgctc aatcagctcc 51780 ttctgaagaa gtaacagcta cagtatctaa cgttgacgat ggtgttaaat taacaattaa 51840 tgttaacgct atgtaccaac aacaaccaca attcgtttct atttaccgtc aaggtaagaa 51900 aactggtcaa tatttcttaa tcaaacgtgt accagttaaa gatgcacaag aagacggttc 51960 aatcgtattc gtagataaga acgaaacatt acctgaaaca gcagacgtat ttgttggtga 52020 aatgtcacca caagtagttc acttattcga attacttcca atgatgaaat taccattagc 52080 tcaaattaat gcttctatta catttgcagt attatggtat ggtgcattag cattacgtgc 52140 tcctaaaaaa tgggctcgta ttaaaaacgt tcgttatatc gcagtttaat agaataagaa 52200 aaactgaata caagagaata gggataaact tagggtttat ccctttttta ttaaaataaa 52260 cttgaaggga ctcaataaat atgttatact ataagaaatt aatagataaa aaaatggcta 52320 ctgtttatgg tacagtcgag attgataaag acggagtagt taaaggatta actaaggaac 52380 aagaaaaaga gtttgcaaat gttccaggtt ttgaatttga agaagaaaag aaaactacta 52440 gaaaacaatc agcttctact agtaaagaag aagaacctaa agaagaagaa aagaaaacta 52500 ctagaaaatc tacaagcact actagaaaat caacagcacg taaaacaaca gccaaaaaag 52560 atgaaactaa ataaagggtg aattaaatgg ttaactcaat gttcggaggg gacttagacc 52620 cttatgaaaa atcattaaac tatgaatatc cttatcatcc tgatggtaac cctaaacata 52680 tagatgtaag ggagatagat aacttaacat tagctgacta tggatggtca cctgatgcag 52740 ttaaagctta tatgttcggt attgtagtac aaaaccctga tacaggacag cctatgggtg 52800 acgagtttta taatcatata ttagaaagag cagtaggtaa agctgagaga gcattagata 52860 tatctatact acctgatact caatatgaga tgagagatta tcatgagaca gagtttaata 52920 gttatatgtt tgtacatgct tacagaaaac ctatattaca ggtagagaac ttacagctac 52980 aatttaacgg tagacctata tataaatacc ctgctaactg gtggaaagta gagcatttag 53040 ccggtcatgt tcaattgttc cctacagcac ttatgcaaac aggacaatca atgtcatatg 53100 atgctgtatt caatggatac cctcaattag caggtgtata cccaccatca ggagcaacat 53160 ttgcacctca aatgatacga ctagaatatg tatcaggtat gcttccacgt aaaaaagcag 53220 gaagaaataa accttgggag atgcctcctg agttagaaca gctagttata aaatatgcat 53280 tgaaagaaat ataccaagta tggggtaact taatcattgg tgccggtatt gctaataaaa 53340 cattagaagt agacggtatt acagaaacaa taggaactac tcaatcagct atgtatggtg 53400 gagctagtgc tcagatactt caaataaatg aagatataaa agaattattg gatggtttaa 53460 gagcttactt tggatataat atgataggat tataaggagg gttagaaaat ggaaaaaccg 53520 tatatgatag gagccaactc taaccctaat attattaata agtcaacaac atatactact 53580 ataacacaag cagatgaaca agataaacct aagtatacta ctagactaga gtttgatact 53640 attgatatga ttaggtttat taatgaccga ggcataaaag tattatggga agaagcatat 53700 ttctgtccgt gccttaaccc tgactcagga catcctagag tagattgtcc tagatgtcat 53760 ggtaaaggta ttgcttattt acctcctaaa gagactataa tggcaataca gtctcaagag 53820 aaaggaacta accaattaga tataggtata ttagatacag gtactgcatt aggtacaact 53880 caattagaaa agagaatatc ctatagagat aggtttactg ttcctgaagt gttaatgcct 53940 caacaaatga tttattttgt aaataaagat agaattagaa aaggtatacc attatactat 54000 gatgtaaaag aagtaactta tatagccact caagacggta cagtctatga agaagattat 54060 gaaattaaga ataacagatt gtatttaaat gaaaaatatg agaaccatac agttacatta 54120 aagatactta tgactttaag atatgtagta tccgatatac taaaagaaag tcgttatcag 54180 tatactaagt ttaatcaacc taaatcaaaa tttgaaaact tacctcaaaa attacttctt 54240 aaaagggaag atgttattgt actacaagac ccttataaag ttaatgatgg tatagaagaa 54300 gacctagaaa ttcaagtaga tgaccctaaa gcttcggcat ctaatcctag taatttaggt 54360 ggattcttcg gaggtgcatt taactaatgc cggttcacgg aaagagacct aacttattta 54420 aaaataagaa ctataagcag gtaggtaaga gaaccattga tggtatgcgt tcagaagttc 54480 ttgacaagct acaagcaaca gcacagcaag tagagaatac tagtattaaa cgtatgccta 54540 cttatctaca agtaacagag aaaaaacttg aaaaagaagg cgtagtagac cttaaaaaag 54600 catttgctcg ttcatctaaa aagaaaacta gtaaagacgg aggatggtat ttaactgtac 54660 caatccgtat taaaactagt agaatgaata atagtaccta tcaagatatg agaaaattaa 54720 aagtaaatca agggacaggt tcagcttcta agataactga ttatctagaa gggcgtagaa 54780 agaatgtaag tcatccatca atgaaaccgg aacctatgac tcacaacatg actaaagtta 54840 aaagaggaaa gcaatcttct tactttatat ttagaactgt ttctagtaaa tcacctgcta 54900 gttcatggat acttaataga gataaagtta atgagaataa tttctctaaa acaactttaa 54960 aaactgttaa gcaactaatg aattggaaga tgaaaaattt aaattaaaag gagggttagt 55020 attaaatggc aataacatca gtcgattcat atttattatc agaaataaag cctagactta 55080 acactgtgct agagaattgt tatattatag atgaagtttt aaaagacttt gattatcaaa 55140 ctagagagag ctttaaagaa gctttctgtg gtaaaaatgc acaacatgaa gtaacggtag 55200 gatttaactt cccaaaattt aaaaataact atgaagccca ttacttgata cagttaggtc 55260 aaggacaaga gacaaaaaac tctttaggga gtattcagtc atcttacttt gaggcaacag 55320 gagatacctt agtcgaatct tctacagcaa taagagaaga tgataagtta gtttttactg 55380 tttctaaacc tataggagag ttaataaaag tagaagatat tgaatttgca aaatttgata 55440 atcttaaagt agaaggtaat aaagtatcat ttagatacca aactaatgaa gattatgaga 55500 attataatgc taacattatc tttactgaaa agaaaaatga ttcaaaaggt ttagtaaaag 55560 gattcacagt tgacgaacaa gtaacagttg taggtctatc ctttaatgta gacgttgcac 55620 gatgtttaga tgctgtatta aaaatgattt taatatctat gagagatagt atagaagagc 55680 aacaaacatt ccaattacag aatttgtctt ttggagatat tgcaccaata atagaagatg 55740 gtgactcaat gatttttggt agaccaacga ttattaagta cacaagttct ctagacttgg 55800 attatactat tacacaagat attaataaac taacttttaa agaaagaaag gattggaagt 55860 aggatggcta gaaaaaagac acctgaaaat aacactccta aatttaatgg ttatgttcat 55920 atagatacat tccttgatac tgcaaaaacc ctttttaata tgagggattc acaagtagca 55980 ggatttaaag cttatatgga aggtagtcat tatttgttta gtgagcaaga attcttaccc 56040 tcattagaga agtacttagg taggaaatta gatatataat aacattcaga taaggagaat 56100 taaatatggc agtagaacca ttcccaagaa gacctattac ccgccctcat gcatctattg 56160 aagtagatac ttcaggtatc ggtggctcag caggttcaag tgaaaaagta ttttgcttaa 56220 tcggttcagc agaaggcgga gaaccaaata cagtttatga attacgtaac tacgcacaag 56280 ctaaacgttt attccgttca ggagaattac ttgatgcaat tgaattagca tggggttcta 56340 accctaacta tacagcaggt aagattttag ctatgcgtac tgaagatgct aaacctgctt 56400 cagtagaagt tggcggatta aaagtaactt ctaaaatcta cggtaatgtt gctaataaca 56460 ttcaagtagg attggaaaaa aatacattaa gtgattcatt acgtttaaga gtaattttcc 56520 aagatgaccg tttcaatgaa gtttacgata atatcggtaa tatcttcaca attagatata 56580 caggtgaaga agctaacgca actttctctg tagaacatga tgaagaaact caaaaagcaa 56640 gtcgtttggt attaaaagta ggagaccaag aagttaaatc atatgactta actagcggtg 56700 cttatgacta tactaacgct attatcacag acattaatca attacctgat tttgaagcta 56760 agttatcacc tttcggagat aaaaacttag aatctaataa attagacaaa gcatcagatg 56820 taaatattaa agataaagct gtatacgtta aagcagtctt cggtgactta gaaaaacaaa 56880 cagcttataa tggtattgta tcttttgagc aacttaatgc agaaggagaa gtaccaagca 56940 atgtagaagt tgaagcagga gaagaatcag ctacagtaac tgctacttca cctattagaa 57000 ctatcgagcc tttcgaatta actaagttac aaggcggtac taacggtgaa ccacctgcta 57060 catgggcaga taaattagat aaatttgcac atgaaggcgg atactacatt gttccattat 57120 catctaaaca atcagttcat gcagaggtat ctgctttcgt taaagaacgt tcagatgcag 57180 gggaaccaat gagagctatt gttggtggag gatttaatga atctaaagaa caattgttcg 57240 gtagacaagc atcattatct aatccacgtg tatcattagt agctaactca ggtacttttg 57300 ttatggatga tggacgtaaa aaccacgtac ctgcttatat ggtagctgta gcgttaggtg 57360 gtcttgcaag tggtttagaa atcggtgaat caattacttt caaaccatta cgtgtaagtg 57420 cgttagacca agtatatgag tcaattgatt tagatgaatt aaatgaaaat ggtattatta 57480 gtatcgagtt tgttcgtaac cgtactaata cattcttcag aatcgttgat gacgtaacta 57540 cattcaacga taagtcagac ccagttaaag ctgaaatggc tgtcggagaa gctaatgact 57600 tcttagtaag tgagcttaaa gttcaacttg aagaccaatt cattggtact cgtactatca 57660 atacaagtgc ttcaatcatt aaagacttta tccaatctta cttgggtcgt aagaaacgtg 57720 ataatgaaat tcaagacttc cctgctgaag acgtacaagt tattgttgaa ggtaacgaag 57780 caagaatttc aatgacagtt tacccaatca gaagcttcaa gaaaatctct gttagcttgg 57840 tttacaagca acaaacatta caagcctaat ctaggttatg gagtacctag attgggtact 57900 cctattaata taatttgaat actttaggag agtgaataca gatggcatca gaagctaaac 57960 aaaccgtcca tactggtaat accgtcctac ttatgattaa aggtaaaccg gtaggaagag 58020 cacaatcagc atcaggtact cgtgaatacg gtacaactgg tgtatacgaa atcggttcta 58080 tcatgcctca ggaacacgta tacttacgtt atgaaggtac aattacagta gaacgtttac 58140 gtatgaaaaa agaaaacttt gcagatttag gatatgcttc acttggtgaa gaaattctta 58200 agaaagatat cattgatatc ttagtagtag ataacttaac aaaacaagtt attatttcat 58260 atcatggttg tagtgctaat aactacaatg aaacttggca gaccaatgaa atagtgacag 58320 aggaaattga gaattttaca ctctgctcat agagtaatct gtgagtatta agggttaact 58380 gctatgaaac ttctaaagct caatcaacca cataggaatt ggaaacaata aactagaagg 58440 ttacgaaagt agaaaaaatg attgagatac tctaaggtta aatcctaagg agaagtacaa 58500 tgggtgtata gcatcgaata ctctaagtga tattaaatca taagaggaac gttcaacgac 58560 tatctcatta taagatgaga gtaaagctcc aagctattgg gagaagaaaa atccttgccc 58620 tactaattag ggataacaaa tagtctagtc acgtagtgaa agctagtgca tgtgaaataa 58680 cacaggttta caaagtagcg tttgtaaata aataaatcgt tttcgtactt gaccgcatca 58740 gataaagcca gaacataagt tcgtatttat tatagaatat agacctaaca ataaaagtta 58800 ggtcttttct attgacaaaa gactaatgat atagtatcat tagtatatac tttaatagaa 58860 gaggtgtttt aatatggaaa ttgaaaaatt agcaaaagaa aaaaatataa aaatcgtaga 58920 atatagaggt agagcaaaag atacaaaaca tttaggtgtt gttttggaag gtaaatttaa 58980 aggttgtgaa tgttacgtgt cctacaataa cttaaataac ttaaaacaaa taagactaac 59040 acaacttaca gaagaaggta aaaagaaata tttttcttct tacgctaaaa gtagagggta 59100 tagtattata aactaccctg aaaatctgca atcaacaaag agatgtttac tactatcacc 59160 gcaagggaat aaatgggatg ttatatggaa tagttttgag aacaatacta ataataataa 59220 ttgtcctcaa gaccatatga aaagtatcgg agagagaatt atacagacta tacttaaaga 59280 aaatggtatc gaatttatat gtgaaaaatc tatctacaca ggattagaga gaccacaaag 59340 attagatttt tatatagaat taaatggtaa taaatatgct attgaatata tggggcaaca 59400 acatattaaa caagctactg gaacatggag tacgccctta gaaaagatac aagagctaga 59460 ttcactaaaa gaaaaatact gtaaagataa taacataaag ttactatata tctattatcc 59520 taatgaagac aaaaaggaca tattaaatac tataagttcg ttcttagaaa ttaatttaaa 59580 ttatactgag agaatagaac tgtttacaaa atataaagaa aatgaaaaag agattataga 59640 attctataaa gaacactctt cagaagaaac tgcaaataaa tttaatatga gtgttggtaa 59700 tgttaaaggt ttaatgaaac gtagaggggt taagaaaaga tttaaacctg tagtaggatt 59760 aaatattaag acactagaag aaattagatt tgatacttta aaagaagcac aggaatattt 59820 tagtaattta ggattacctt catcaagtat tagagggtgt gtatcaggaa gtaaaaagca 59880 atcatgtggt tatctttgga gatatgaaga tgaagacttt tcagaagtag ctaaaacaat 59940 aacagacaaa agaattaaag tatatgtagc aactaaaggt tcagaagata ttaagttgcc 60000 tttgcatatg atgacaaaaa gaataagttc agatgtagca tccattgtag attgtgctaa 60060 aggtaaaaga aacactgtta aagggtacaa tattagagaa gctacagaac aggaaaaaag 60120 tgatacacta aaaagtataa gctatattga ctatatacaa aattataaat aacctttgac 60180 caataccaag ggttatgtta ttataataaa taaggaggga ttaacttgac aaatagaaaa 60240 acaataggta aaatgagtaa tacaagggca acatggaata ttaaccctgt aactaaagtt 60300 aagaaagata aaactaaata ttctagaaaa aataaacata aaggtcttga caattataat 60360 tagatacagt atactaagat tataacaaat aaggagatgg attatatgag tacattttgg 60420 tcaaaaagaa gaacaaccgg taaagacagg caagtaaaga aacattatac tcaaatgtct 60480 ttacaagaaa agaagcagtg tgttaaacta ttacaagata caattaatac acataaatat 60540 ttagaactat caaaccattg caaaactaaa attaaaaatg aaatcaattt tagtaagtta 60600 gtaggattta tatttaaaag taataatgca ccttttaata ttattgaatt taatattaca 60660 gattttcatg gtaaaaagca aagaaggatt atttttaaaa gtcctactat tgtaactata 60720 gaaggagtaa gtagttatca gtacttagtt attaacctgg aagatggtaa aataataact 60780 acatactata atggcattac agatacacac aaaacattag atttaaatta ttatgataaa 60840 ggcttgacaa ttaaataagg aggaattata atgggattga caatagtaaa tagttacttt 60900 atcctatcaa gtattatatt tattgtatta agtatattaa atggtaaggg tacagttaca 60960 gaggaatcac tagctatgag taaagcatta gtggtaataa catcagttca atttttagca 61020 tgtttaatta ttaatggtgt ttattactca ttaaaatata tgtaaaaaaa gtattgacaa 61080 attaaaaata ataaattata ataaagatat aacaaattaa aggagaagat ataaaatggc 61140 acaagataaa ttaagagcag tttatgaaga gatgaaagta gaattacaaa aattcccaca 61200 agaggtagat gtaacaagta aatcaacagc aattgcaatc aatcagattt tagataaatt 61260 caaaacatta actgagcaag caggaaagat tactaagaaa tatatagaag gtcaagaaat 61320 attaactatt gattatgagt attatgattc attacaagaa tactacattt atttactaag 61380 aaatagtgat aaaattaaac aaagtttaga ggaaatttta acaagcacag agaaatactt 61440 aaagtaattt tgatttaaaa acaaaatatg atatactata tttaaagtag taagcctaca 61500 ctagtccgtg ttatattaat attgaatcgg ataagcgtag gctttattaa tatttaaaaa 61560 aggaaggtat atcatattat ggcagaagaa attaaaaagg aacaagaagt acaagaaaca 61620 aaagaagaga aaaaggatgt cagtaaaatg acaccggaag aaatagataa attaaaatac 61680 caagacaagc aagaaaaaga aaaagttatt aacaaagtta ttaaaggtgt taatgacaca 61740 tgggaaaaag agtataactt tgaagaatta gacttacaat ttaaagttaa aattaaattg 61800 cctaatgcac gtgaacaagg taatatcttt gcgttacgtt ctgcttactt aggtggtatg 61860 gatatgtatc aaacagacca agtaattaga gcttatcaaa tgttagctac attacaagaa 61920 gtaggtattg aagttcctaa ggaattccaa gaccctgagg atatctataa cttatatcct 61980 ttaactgtta tgtatgaaga ttggttaggg ttcctaaact cctttcgtta ctaatagtat 62040 agaaacacta gataaagata tagaacgatt gggtggtatg gaatcaattg ttaaacaacc 62100 tttatctagg aatctatggg ctattatgaa agagtttaat gttttaccta ctgagcaaag 62160 atttaaggac ttagatgact atcaaataga gtttattatt ggtaatatga acagagatgt 62220 ttatgagcat aataaacaaa ttaaacaagc tcaaaaaggt ggcaagtacg atagtcaatt 62280 cgaagatgat gatagtagtt ggtggaatga atctcatgaa gactttgacc cagtacctga 62340 tttcttagat gctgatgact tagcacaaca gatggaagct aaattatctg acagagataa 62400 ggaagaaaga gctaagagaa atgatgcaga gttgaatgat gagacagaag gactcactac 62460 acaacatctt gctatgatgg aatacattag aagaaaacaa gaagaattag atgatgaagt 62520 aggaaacggt aaaactagtg aagatgatgc tactatatca caagagagcg ttaataaagc 62580 actagaagac ctagatgatg attggtatat gtaaagggtg gtaggtgata ctaccatcct 62640 tattttttta aaatggatgg tgagtaatga tggcaatgaa tgacgattat agattggtct 62700 tatccggtga tagttcggat ttagagaata gtctgaaggc tatagaactt tatatggact 62760 ctttagaggc taaaaatatt gatgcccctt tagataattt cttaaagaaa ttaaaagtaa 62820 ttgctaaaga agttaagaat gtacagaatg caatggataa acaggaaggt aaatctgtag 62880 tatctgctaa agatatggat gagaccatta aatctactca atctgctacg aaacaaataa 62940 atgagttgca gaaagcttta gatgaccttc aaaaagaaaa tatatctaaa ggtatagcac 63000 ctgaccctga agttgaaaaa gcatacgcta agatgaataa agttgttaat gagactagtg 63060 aaaatcttag taaaatgtct aaccaaaaaa taggctcaga tgcaagtatt caaaatagaa 63120 ttaaagaaca gaaaacctta aataaagtaa cagaagaata taataaaatt agtaaagatt 63180 ctagtgctac tcaagattat acaaaacgtt taagagctaa ccgtaatatg actagaggtt 63240 acatggaacg ttcagaagga acaggacgtt taacatatga ccaaggggca cgagttagaa 63300 gtgaactagg taaggtagat tcttatgaaa gtcaaagaaa acaaaaccaa cgtaatttaa 63360 gccaagcaag agaacaatat agtaattacg gtaaacaaca acaagacctg actaaccgta 63420 gagctagtgg tcaaattaat aaagctcagt atgaaaaaga gctagcttct attaaaatgg 63480 aaatgaaagc tagagaagaa cttatatcta actatgaaaa attaggagca gagcttgata 63540 aaactgttca atattatagg ggttcagtac aacaagattt tcaaactaga agagtagacc 63600 aacaacgagg gacattcggc agaatgattg aggagcgttt accatctatc ggttctcacg 63660 caggtatggc tatgacaggg gctatgacag gtctatacat gaaaggtgct tctctaagtg 63720 aatcaaatag accaatggtt acatcattag gtcaaaattc agataatatg gatatagatt 63780 ctgtaagaaa tgcatatggg gacttgtcaa ttgataacaa attaggttat aatagtaatg 63840 acatgttgaa aatggctact tcatatgaat catcaatagg acataaaagt gatgaggata 63900 caatggcagg agctaaacaa cttgctatcg ggggacgttc attaggaata caagaccaag 63960 aaatgtacca agaatctatg aatcaactaa tgcatactgg tggagtaaat tccaataaca 64020 tgaaggaaat gcaagatgca ttcctaggtg gtattaaaca atcagacctg attggtcgtc 64080 aagatgaaca acttaaagca ttaggttcta tagctgagca atcaggagaa ggtcgaacat 64140 taactaaaga ccaaatgggt aatcttacag ctatgcaagc aacttttgca gaatcaggta 64200 gtaaaggttt acaaggtgaa cagggtgcta acgctatcaa tagtattgac caaggactta 64260 aaaatggtat gaatagttct tatgctcgta tagcaatggg atggggaaca cagtaccaaa 64320 gtcttgaagg tgggtatgac ttacaaaaac gtatggatga aggtatatct aatcctgaaa 64380 acttgactga catggttgat atggctactc aaatgggtgg tagtgaaaaa gaacaaaaat 64440 atttatttaa cagaagtatg aaagagttag gctctaacct tactatggag caatctgatg 64500 agatatttaa agatgctcaa tcaggaaaac tatctaaaga agagttatct aaaaaaatta 64560 agaaaatgga aaaagaaggt agtaaagaag gagaagataa tagaaccgat tatgaagagt 64620 ctaagtcagg tagaaatgac caaaacaaag ctaaaacaga tgataaagca gaggatattt 64680 atgatttagc tcaacctgta agagatgttc atagtgcctt tgcaggtctt ccggcaattg 64740 tatacgccgg agccactgct gtaggggtat tcacggcttc tttacttgca tctgcaggac 64800 aatttggttt gggtcgtgta gtaggtaaag gtaaacaatg gatagataag aaaagaaatg 64860 gtggtaaatc aggaggagga acaccgcctc caggaacaag cccaggtaga caaaaatacg 64920 ctaataataa tcctaaaaca cctaatggcg gaggaacttc aggaggttct agagtaggta 64980 gtatgtttga aaaagctaag agctttggag gaaaagctct tgccggaggt atgttatttg 65040 gtgataaatt attaggtggt aaaaataaaa aaggcggaac tcgttccgga aaagaacagt 65100 ttaaaggtac ttgggatagt actaagaaaa ctggtaaagg gttatttgac cacttaaatc 65160 ctaagaaccg agactttact atgggagatt acttaggtag aacaaaagat ttaggtaaaa 65220 aaacaggtaa aggtataaaa ggttttggta aggagacatt tagtgggagt atactacatc 65280 ctaagaattt taaaggctta ggagataaaa ctaaaggtct tggaggcaaa ataaaatccg 65340 gaacaggtag tttacttaat aaaggtaaag gtgcttatgg taaatttgct gataagtttg 65400 gtgatggaag taaaaatggt attatgtcac aatcaccaaa agcaggtgga atagataaaa 65460 ctttaggtaa aggaaaagac ttagctaaaa aaggtttagg tgcaatgcct aaaggtgtag 65520 gggcatttgg taaaggtgca ggtaaattag tttctaaatt cgtacctgga cttaatatag 65580 gtttatcagc tcttaacttt ggtagcagga tgaagaatgg tgaaggtgta ggggaagcct 65640 tatctaacac agcaggtgac tttatagacc catttggatt aggttatggt gaaaaagtcg 65700 gagatatggc taagaaagct gagaccaaag agggatggaa cctaggatgg tctaatggag 65760 acaaagatgg taagaataaa ttccaagatt ctgtaatagg aaaacctata tctaaagcat 65820 ggagtggtat aacaggactc tttgacaatg aagctgaagc atctgaagaa gatagtaaag 65880 atagtaaaaa aggcgttaaa ggtgttaaaa aagataataa gaaaaaagaa aaaatgacag 65940 cagaacaact tagagaaaag aataatcaat ctgaaactaa gaaccttaaa atctatagtg 66000 atttacttga tagagctcaa aagattattg agagtgctaa aggtattaat atagacggag 66060 gaacatctga aggtggttct gacggaggct ctgcatctga tgtaggtgga gaaggtgcag 66120 agaagatgta taagttcctt aaaggaaaag gactatctga caatcaggta ggggctgtca 66180 tggggaactt acaacaagaa tctaatcttg accctaatgc taagaatgct tctagcgggg 66240 cattcggtat tgctcagtgg ttaggggata gaaaaacagg attagaaaac tttgctaaat 66300 ctcaaggtaa gaaatctaat gatttagatg ttcaactaga ctacttatgg aaagaaatgc 66360 aatctgatta cgaaagtaaa aatcttaaga atgcaggttg gagtaaagat ggaagtttag 66420 aacagaatac aaaagcattt gctaccggat ttgaacgtat gggagcaaat gaagctatga 66480 tgggtactcg tgttaataat gctaaggaat tcaagaagaa atacggaggt tccggtggag 66540 gaggcggtgg aggtgcctta tcctccacat accaagaagc tatgagtaat ccagtattaa 66600 ctactggttc taactacacg ggctctaatg atgcttctaa tgcttctaca acgaatcgaa 66660 taacagttaa tgttaacgtt caaggtggaa ataatcctga agaaactgga gacattatcg 66720 gcggaagaat tagagaagtg ctagatagta atatggatat ctttgcaaat gaacataaga 66780 gaagttatta gtaattttgt cttgacacaa gagtagtatc atagtatact actcttatac 66840 atataaaaaa ataaaaggaa gtatgtgtat atgcgtagaa taagaagacc taaggtaaga 66900 atagaaattg ttacagatga taatacattt acattaagat tcgaagatac acgagattat 66960 aatggtgatg aatttggggc taaactatta ggatttcaaa ctaaaaactc tatggaagac 67020 gatagttcag ttttccaaat caatatggca ggagatactt attgggataa gctagttatg 67080 gctaatgata ttataagaat atttattact cctaatgatg accctaacga taaagaagga 67140 agacaagaac gactcattca agtaggtatg gtttcccaag tatcaaaagt aggtagttat 67200 ggtaatgacc aaactcagtt tagaataaca ggtcaatctt ttgtaaaacc atttatgaaa 67260 tttggattag gtgttattca agaggttcaa gctgtattac ctgaagtcgg ttggcttatt 67320 gatggtgatg gagataatga agtaaaattt actggtagct cagcccatga ggtaatgaca 67380 ggaattatac gtagattcat accgtatatg aaatataact acactgaaaa aacatataat 67440 acaatagata gctatcttga ttatgatgat ttaagtagtt gggatgagtt tgagaaactt 67500 acagaagttt ctgcgtttac taattttgat gggtcattaa aacagttaat ggatatggtt 67560 acagctagac cttttaatga attgttcttt aaaaactctg aaaaaacacc aggtaaagca 67620 caacttgtat taagaaaaac accttttaat cctactgagt ggagagcttt ggatatgatt 67680 aaagtaccta ccgaagactt cattgaggag gatgtaggta aaagtgatgt agagacatat 67740 tctatattta cagctacacc tgcaggtatg ttaaaagaac ttaatggtga tgtattctct 67800 aaaccacaat ttcatcctga attgactgat agatatggat atactaaatt tgaagtagag 67860 aatatctatc ttagtaccac atcaggctca gctacagaag attcagattc aacaggagat 67920 gacaacggag cagaacgagg tacgtattcc aaaatcatga aagacttaag taactatggt 67980 agagataatg tttctaaagg tatagacaaa tatacaagta agttatcagc taaatataat 68040 aatctaaaga aagcacaagc taaaaagatt atagagaagt atgttaaaga aggaaaagta 68100 acagaaaaag aatatgagaa aataacaggc aataaagtag aagatgaatt aacatcagat 68160 aacagaccga agttgacaaa gagtaaatta aagagtatac taaaagagaa gtttaaaaca 68220 caagatgatt ttaataattc caagaaaaag aaaaaggcta aaaaagatgc acttaaagaa 68280 ttgacaacta aatatcgttt tggtaataaa acacacgcta caactttgct agatgaatat 68340 attaaataca aaggagaacc acctaatgat gaggcttttg ataaatacct taaagctata 68400 gaaggcgtga gtaatatagc tactgatacg ggctcagatg caagtgatag tcctttagct 68460 atgttctcta gaatgttatt taattggtac catggtaacc ctaacttcta cgcaggtgat 68520 attattgttc taggtgaccc taaatatgat ttaggtaaaa gattatttat tgaggataag 68580 caacgaggag acacttggga attttatata gaatctgtag aacataagtt tgattataaa 68640 cagggttact atacaactgt aggagtaact agaggtttaa aagatgctat cctagaagat 68700 ggtaaaggaa gccctcatag atttgcagga ttatggaacc aatcatcaga cttcatggga 68760 ggtctcatgg gagaagatac atccaaagag cttaaagaaa aaggagtatc agagaaggaa 68820 agtagcggag ataaagatgg aggctctgat agtggaggag ctcaagatgg aggttcacta 68880 gcttcactta aaaagtttaa cggtaaactt cctaagcatg acgctagctt tgttcagccc 68940 ggtaaccgac actacaagta tcaatgtaca tggtatgctt acaacagaag gggtcaatta 69000 ggcattcctg tgcctttatg gggggatgcc gccgactgga ttggcggtgc taaaggagca 69060 ggttatggcg taggtaaaac ccctaaacaa ggtgcctgtg ttatttggca acgaggagac 69120 aaaggcggtt ctaatgctta tggtcacgtt gcctttgttg aaaaagtttt agatggtggg 69180 aagaaaatat tcatttccga gcataactgg gctacgccta atggctatgg tactagaaca 69240 atagatatga gctctcaaat aggtaaagaa gctcaattca tttacgataa gaaataaagg 69300 aggatagttt atggcaacag ataaagaagc taaagatgtt attgataagt ttatagataa 69360 tgtgtttaat tttgatgtac taactacgga aagagttaaa gaaaaagatg aagaaattaa 69420 aaaaatcact acagaagata tgtatgagaa ggttgtttat atacgacctt acgttggggt 69480 aatccaaagc ctaaaccctc aacatgtgca atatgaatca ttttctaata atgggtatga 69540 tgtagaagca gaattaagtt ttaggaaagt aagttatcta acagataaag ggtctatacc 69600 tacagattct ttatctactt taacagttca tttagtagaa agaaatcaag aattactaat 69660 agattatttt gatgagattc aagatatact atatggagaa tatatggaag aagaatatat 69720 atttgatgag gatgtaccat taagtacgat aatagcatta gacctaaatg ataatcttaa 69780 atccttatca aatataaagt atatgttcaa aggtgctcct aaagagaatc cttttggaac 69840 agataaagat gtttatatag atacttataa tttattatat tggttgtatt taggtgaaga 69900 tgaagagtta gcttacccta tgaatattaa ctatttcttt acagaaggaa gattttttac 69960 tattttcggt aaaggacata agtataaagt agatgttaat aaatttatag ttggagatat 70020 attattcttt ggtagaagtg atactaatat aggtatttat gtgggtgacg gagagtttat 70080 atctatgata ggtaaattcc ctaaagatga aacatctata gggaaatata aacttgatga 70140 ttattggaat gaatttaacg gaagagttat gagattcgat gaagaggagt atatttaatg 70200 gtagtaagat tccaatcttc catgggaaga agtttaaaaa gagtagattc agatgattta 70260 aatgtaaaag ggttagtttt agctacagtt agtaaaatta actataaata ccaatcagta 70320 gaagttaaag ttaataattt gactttagga agccatatag gtgatgacgg tagcttagct 70380 gtaccttatc ctaaatcttt cataggtaga acacctgaag gaagtgtatt cggtacaaaa 70440 ccgcttatta ctgaaggctc tgtagtatta ataggatttt taaatgatga tataaacagt 70500 cctatcattt taagtgtata tggtgataat gagcaaaacc aaatgattaa tactaacccc 70560 ctagacggag gtaaatttga tacggatagt gtttacaaat atagtagtgc actatatgag 70620 atactcccat ccttaaatta taagtatgag gatggtgaag gaacaagtat taaaactttt 70680 aatggtaagt cattcttctc tatgacatca ggagaagaag agaaacctca agcaacagat 70740 ttctatacag gaacagagta tcaagattta tttacttctt attatggtaa taagacatta 70800 attgagccta gaatacaaaa ggctcctaac atgttattca aacatcaagg agtgttttat 70860 gatgacggta caccggataa tcacataact actctattta tatctgaaag aggggatata 70920 agggcttcag ttctaaatac agaaacacag aagagaacta cacaagaaat gtcaagtgat 70980 ggttcatata gagtcgttaa acaagatgat gacctaatgc tagatgaagc tcaagtatgg 71040 attgaatacg gtattagtga agataataaa ttctatatta aaaatgataa gcataaattt 71100 gaatttactg atgaaggtat ctatatagat gataaaccta tgctagaaaa cttaggtgaa 71160 agtataacag aggctatgaa gaatctaaat gaaatacaaa aagaactaga tgatataaac 71220 tatcttcttg agggtgtagg taaggataat ttagaagaat taatagaatc tacaaaagaa 71280 tctattgaag catcaaataa agcaacttca gatgttaata gacttacaac tcagatatca 71340 gaggttagcg gtagaactga gggtattata actcaatttc aaaaatttag agatgagact 71400 tttaaagatt tttatgatga tgtttctcct gttataactg aagtaaatca gaatttccct 71460 agtatgaaaa cagatgttaa taacctaaaa actaaagtta ataacctaga aaaaactgag 71520 atacccaata tcaaaactag actaacagaa ctagaggata ataataacaa tgcagataaa 71580 ataatttcag atagaggaga gcatataggt gctatgatac agttagagga gaatgttact 71640 gtacctgcaa gaaaatatat gacaatacct tggagtaaag ttacttataa taatgcagag 71700 ttttgggatt ctaataatcc tactagatta gtagtaccta aagggataac aaaagtaaga 71760 gtttcaggta atgctttgtg ggattctaac cctacaggac aacgtatgtt gagactattg 71820 aaaaacggta cttatagtat aggattgcct tatacaagag atgtagctat atctacagca 71880 cctcagaacg gtgctagtgg agttattcct gttaaagaag gagactattt tgagtttgaa 71940 gttatacaag actcagaagg ggatagacaa ttcagagcag acccttatac atggtttagt 72000 attgaagcta tagaattaga aactgaaacc atggagaaag acttcatgct tataggtcat 72060 agaggggcaa ccggatatac agatgagcat acaataaaag gatatcaaat ggctttagat 72120 aaaggtgcag attatataga gttagattta caattgacaa aagataacaa gctattgtgt 72180 atgcatgatt ctactatcga cagaacaaca acaggaacag gtaaagtagg ggatatgact 72240 ttatcttata tacaaactaa ctttacatct cttaacggag aaccgatacc atctttagat 72300 gatgtattaa atcattttgg aacagaagtt aaatactata tagaaactaa acgtccattt 72360 gatgctaata tggataaaga gttattaacc caattaaaag caaaaggact aatagggata 72420 ggttcagaga gattccaagt aatcatacaa tcgtttgcta gagaatcatt aatcaatatt 72480 cataatcaat tctctaatat acctttagct tatttaacaa gcacattctc agaagcagaa 72540 atggatgatt gtttaagtta tggttcttat gctattgctc ctaagtatac aactataact 72600 aaggagttag tagacttagc acatagtaaa ggacttaaag tacatgcatg gactgtaaat 72660 acaacagatg aaatgcaaag cttaatacag atgggtgtag atggattctt tacaaactac 72720 ctagatgaat ataaaaatat ttaatattaa agacctatta atttaggtct ttttttagtt 72780 gtaatttaaa ctagttcgtg atatattagt agtatgagat ttatatacat actgaaaagg 72840 agaggataaa atgccacaat cagacggaat aagtagcctt catagaatag ccttacgttt 72900 ccctaaagag ggcggtggtt atgatatgta tagatttaaa gttaaccctg agaattacac 72960 aatagatgca ccacaacgta caacagcaat taaaacaaaa tcggatattg tagtagaaga 73020 ttatggtaaa gacatagaag ttattaactt ctcaggtact actggattta gaccagttag 73080 agaggtagat ggattaaaaa caggtaaaca gaaaatggat gagttacaga aaagggttac 73140 tgactatgct acccaaggag gtaacggtaa tgtaagtggt tcctacttac aattctttaa 73200 cttcacagat ggtaagtatt ataaagtaca tctagcaccg caagggctta aaataactag 73260 gtctaaagat gaaccgttac tttttagata tgaaataaca ttagtagtta ttggttcact 73320 aacagaagca gatagaagtg ctgtaacaac agaagagttt ggtaatgtta atcctaacgc 73380 ttctcaaaga gtagatgaag gtctaaaaga gttagataaa aatgctcgta aaacgagaga 73440 tagaaataac caagaaatat ctagaagaga aaatacaata cctaaatcta caggagataa 73500 tacaaacgag agtaacagat tgaagcaaag tttccctagt agctctatat ataatcctag 73560 acaatctact aatggattaa aaggaaacat tgataacatg gctttaataa taggttatgg 73620 tgatggaggt gtatctagtt aatgaataat tttatagcac aaccacaagg tttacttaga 73680 tttttaaatg ctttagacac agacttaact tattctcaca tgaatttact tgatgaagag 73740 atatcatttg tatctaaatt ttatacacca caactacaat taagtgaatt agcaaaaaaa 73800 gtattgacaa atctaaagac agatgatata cctgtattag aaagagaatt taacgataat 73860 acaattattc ataaagctaa taatacatca ctaaaagtcc aagcacctag aatgtatatg 73920 attctacaat ctattgtcct tgaagcatat gctattgtta attgctttgt agagaatcca 73980 agttctttaa aatatttaac tgaagaagat attaatataa cacgagaaaa cttgaattat 74040 gtagcagatt acttaggtaa ctatgatgac tataatagtg ttgttttaga tttaagagag 74100 ttagatttat gttttagtgc aatagaatta caactacctc taattaaaaa ggaggctaac 74160 gtataatgag atttaagaaa catgtagttc agtatgaaga aacaatgcaa gcaatagcac 74220 aaagatatta cggggatgtt agttactgga tagacttagt agagcataat aacttaaagt 74280 acccttacct agtagaaact gatgaagaga aaatgcaaga ccctgaaagg ttagcttcta 74340 caggagatac aattattata cctatagaat ctgatttaac agatgtatca gcaaaagaga 74400 ttaattctag agacaaagat gtattagttg aattagcttt aggaagagat ttaaatatta 74460 ctgcagatga aaagtatttt aatgagcatg gtactagtga taatatacta gcatttagta 74520 caaatggtaa tggggattta gatactgtaa aaggtataga caatatgaag caacaattac 74580 aggcacggtt attaactcct agaggttctt taatgcttca ccctaactat ggttcggatt 74640 tgcataattt atttggtctt aatatacctg aacaagctac attaattgaa atggaagtat 74700 tgagaacatt aacatcagat aatagagtaa aatcagctaa cttagttgat tggaaaatac 74760 aaggtaatgt ttattcagga caattctcag tggagataaa atctgttgaa gaatcaataa 74820 attttgtttt aggacaagat gaggaaggaa tttttgcttt atttgaatag gaaaggatta 74880 aattatgaaa actagaaaat taactaacat actatcaaaa ttaatagata agacaatgac 74940 aggtacaagt aagataacag attttacccc tgggtcagct tctcgttcat tattagaagc 75000 tgtatcatta gagatagagc aattttatat cttaacaaaa gaaaatattg attggggtat 75060 acaagagggt attattgaag cctttgattt ccaaaagaga caatctaaaa gagcttatgg 75120 tgatgtcact attcaatttt atcagccttt agatatgaga atgtatatac ctgcaggaac 75180 aacttttact tcaacacgac aagagtatcc gcaacagttt gaaacattag ttgattatta 75240 tgcagaacct gactctactg agattgttgt tgaagtttat tgtaaagaaa caggagttgc 75300 gggtaatgtt cctgaaggaa caattaacac tatagcatca ggttctagtt tgattagaag 75360 tgttaataat gagtattctt ttaatacagg aactaaagaa gagagtcaag aagactttaa 75420 gcgtagattt cactcttttg tagaatctag aggaagagca actaataaat cagtgagata 75480 cggagcatta caaatacctg atgtagaagg tgtttatgtt tatgaagaaa caggacacat 75540 aacagtgttt gctcatgata gaaacggtaa tttatcaaat actttaagag aagatataat 75600 tagtgcttta caagactata gaccaagtgg tataatgtta gatgttacag gggtagaaaa 75660 agaggaagtc aatgtttctg ctacagtaac gatatctaat aaatctagaa ttggtgatac 75720 attacaaaaa catattgaag gtgttattag aagctattta aataatttaa aaacttctga 75780 tgacctaata attacagacc ttattcaagc tgtaatgaat attgatgatg tattaatcta 75840 tgatgtgtca tttgataact tagatgaaaa tattatagta ccaccacaag gaattattag 75900 agcaggagaa ataaaagtag aactaatgta aagagaggtg aaaattaagt cgtggctaat 75960 tttttaaaga atcttcatcc attattaaga agagatagaa ataaaaaaga taatcaagac 76020 cctaactttg ctctaataga ggcactcaat gaagagatga atcaagtaga gaaagatgct 76080 atagaaagta agttacagtc atcacttaaa acagcaacaa gtgaatactt agataagttt 76140 ggagactggt tcggtgtcta tagaagaaca aatgaagatg atacagcata tagagcaaga 76200 attataaaat acttactctt gaaaagaggt acaaataact ctataataga agctataaaa 76260 gattatctag gtagagatga tattgatgta agtgtgtatg aaccttttac aaatatcttc 76320 tatacgaaca aatcacattt aaatggtgaa gaccatttaa tgggttatta ctatagattt 76380 gctgttatta atgtctctat aggtgattat ttccctatag aggttgtaga tgtaattaat 76440 gaattcaaac ctgcaggtgt aacattatat gtcacttatg acggagcctc tactattaga 76500 gggggagcaa ttattaagtg gctagaaggt ctacctaaaa ttgaaacata ccaagagttt 76560 gatagattta taggttatga tgacacattt tatggtcatc ttaatatgaa tcaaagtaaa 76620 gataatgata atagttcatc agacattttt aaaacaaatc atagcttaat taatagctta 76680 gatgttttaa ccggttcctc tagtgtaggt agacagtatg ttaactatgg gtatataaca 76740 tcatatgttt ataatccaag tatgacatct tctgtaaatc aaataagttc tagtacagaa 76800 gatagagggc aagaagtacc tactgactac tatatgtata ctagtattaa gaataacaat 76860 acagtagaac taaacatgca aactagttcc ggtgtgtctt atttatataa taactttaat 76920 tttagagatt atatgagtaa atatagacct gaagtagact tacaatctga tgagtctaga 76980 agaattgtat ccaattatgt aaaagaatta agtattgatt actaccttag tgctgtaata 77040 cctcctgatg agagtataga aattaaacta caagtttatg acttctctat taatagatgg 77100 cttacagtat caattaataa cttgtctttc tatgaaaaaa atattggtag taatataggt 77160 tatataaaag attacttaaa tagtgaatta aatatgttta ctagattaga gataaatgca 77220 ggtagaaaag gttcagtaga tattaaagtt aactacttgg atttaatgtt ttattactat 77280 gaacgaggta tctacacaat aaaaccttat aaagcattag tagaaaatta cgtagatatg 77340 tctagagata ctaacgtaga agcatttaaa gtaacatcgt tatctaatgg agatatcata 77400 actaaaacag gtttccaacc tataagatac cttaaattaa ctgctactta ttctactgaa 77460 cccactacat taactttaac cggaagcaca tctagtaatt attcttacag ttctatagat 77520 atttcggaat cattaccagt taagtctaat atcatagaaa gagagcttgt atataatgat 77580 ataaaaactg atttacagtc tattataata aattccaacc aaccactaac aaatgttcaa 77640 ttaagttact cctattatgg tgatagttgg gttgttttaa aagaaataga taatttaacg 77700 gaaggaacaa ccactatatc aaataactta atagatttgt atggattgca aacagtagat 77760 tattctaata taaatccaat gtcagaagta tcattacgtt ctatttggaa tgttaaatta 77820 ggtgaactta ataatataga aggttcttta tctaatatgt ctaatgatta ttttaatgct 77880 gtatggcaag atatagataa actatcagat attgatttag gttctatgag aatagttaaa 77940 gacactgaag gtggcgtatt tgatggagct acaggtgaag ttattaaagc tactatattt 78000 aacgttggtg tttatactga tttagacatg ctatcttata ctctaaataa ctatactgag 78060 ccattgactt tagggtctag tagactaata agtgagctta aagatgagtt attaacaaca 78120 gaatcactta atatagataa cagaattaaa gtaatataca ctgatacaga aattacaatt 78180 aatgaataaa taagttgaca ggaagttaat aatatggtat acttataaag taatatttag 78240 tgggtatacc atgttatatt aataaagaaa acaacagatg aaaggaatta aaaactatgg 78300 caattgcaac gtataattct catgttgagt tagcaaaata tatagttagt aaagctgact 78360 cagtttactt aacaattgga aagagcacac cgtggtctaa tgaaacaaat ccaccacaac 78420 ctgatgaaaa tgcaacagta ttacaggagg ttattggata taaaaaagct actaaagtta 78480 ctttagttag acctgctaaa tcacctgaag atgataataa gaatttaatt tcttatggta 78540 ataaatcatg ggtagaagta acacctgaag atgctaagtc agaaggagct aagtgggttt 78600 acttagaaag tagtattgtt ggagacgaac tacctcttgg aacatataga caagtagggt 78660 ttgttatgga cttagtagca aaaagtggta ttagtaaatt taacttagta ccgagtgaag 78720 tagaatcagt tggaacatta ttattctttg acaataaaca gttccaaaat agaagtgagc 78780 agacaactgc taaagaaaga tttattgtag aagtttaaag aaagggagat aattctaaat 78840 ggcaattaat tttaaaggtt caccttattt agatagattt gacccgtcta aagatagaac 78900 aaaagtatta tttaatcctg atagacctct acaacaggca gaattaaatg aaatgcagtc 78960 tatagaccaa tattatttaa aaaatctagg agacgctatt tttaaagacg gagataaaca 79020 atcaggactt ggattcacat tgactgaaga taatgtattg acaataaacc ctggttatgt 79080 atatattaat ggtaaaataa gatattacga tagtgatgat tcagttaaaa taactggagt 79140 aggtaaagaa actatcggta tccagttaac agaacgcatc ataacacctg atgaagatgc 79200 tagtctatta gaccaaacta gtggagtacc aagttacttc tctaaaggtg cagatagatt 79260 agaagaaaag atgtcattaa cagttaatga ccctacctca gcaactatat atactttcat 79320 ggatggagat ttatatatcc aatcaactaa tgctgaaatg gataaaatca ataaagtatt 79380 agctgagcgt acttatgatg aatcaggttc atataaagta agtggctttg agttattctc 79440 agaaggtaat gctgaagatg atgaccacgt ttctgtagtt gtagatgcag gtaaagcgta 79500 tgtaaaaggt tttaaagtag ataaaccagt atctacaaga attagtatac ctaaatcata 79560 tgacttagga acagcagaga atgaaagtac agttttcaat aaatctaata actctattag 79620 tttagctaat agtcctgtaa aagaaataaa acgtgttaca ggtcaagttc ttattgaaaa 79680 agaacgagtt actagaggag gacaaggtga cggtcaagac ttcctttcaa ataacacagc 79740 atttgaaatt gtaaaagttt ggactgaaac aagtcctgga gttactacaa aagagtataa 79800 acaaggagaa gactttagat taacagacgg tcaaacaatt gactggtcac ctcaaggtca 79860 agaaccttca ggaggtactt catactatgt ttcttataaa tacaataaac gtatggaagc 79920 tggtaaagac tatgaagtaa caactcaagg tgaagggtta ggtaagaaat ggtacgttaa 79980 ctttacacct tcaaaagggg ctaaacctat tgaccaaaca gtagtattag tagactacac 80040 ttactactta gctcgtaaag attcagtgtt tattaataga tacggtgata ttgcaatatt 80100 acctggtgaa cctaacatta tgagattagt tacaccacca ttaaatacag accctgagaa 80160 tttacaatta ggtacagtta cagtattacc ggactcagat gaagcaattt gtatttcatt 80220 tgcaattact agattatcta tggaagactt gcagaaagtt aaaacaagag tagataactt 80280 agagtataac caagcagtaa atgctttaga tgatggtgct atggaaggac agaacccatt 80340 aacattacgt tcagtgttta gtgaaggttt cattagtctt gataaagcag atattactca 80400 tcctgacttc ggtgttgtat tcagttttga agatgcagaa gctactttag cttatacaga 80460 agcagttaac caacctgaaa ttattccagg agatacaaca gctcatattt ggggtagatt 80520 aatttcagca ccatttactg aggaacgtac aatctatcaa ggtcaagcat cagaaacact 80580 aaatgttaac ccttataata ttcctaataa acagggtgta cttaagttaa cacctagtga 80640 ggataactgg attgatactg aaaatgttac aatcactgaa caaaaaacta agaaagtaac 80700 tatgagacga ttttggagac ataatgaaag ttactacggt gagactgagc attacttgta 80760 ctctaactta caattagatt ccggacaaaa gtgggaaggt aaatcattag cttatgataa 80820 agcacatggt agaacaggta ctttattaga atcaggagga caacgtactc tagaagaaat 80880 gattgaattc attagaatca gagatgtatc cttcgaagtt aaagggctaa atcctaatga 80940 taataactta tatttattat ttgatggtgt aagatgtcct attactcctg caactggtta 81000 tagaaaaggt tctgaagatg gaactatcat gacagatgca aaaggaacag ctaaaggtaa 81060 atttactatt cctgcaggta ttcgttgtgg taaccgagaa gttacactta agaatgctaa 81120 ctctacaagt gctacaactt acacagctca aggacgtaaa aaaatcgttc aagatattat 81180 tatcagaact cgtgtaacag taaacttagt agacccatta gcacaatcat tccaatatga 81240 tgaaaacaga actatttcat cattaggttt atactttgct tctaaaggtg ataaacaatc 81300 taatgttact atccaaatta ggggtatggg tgaccaaggt tatcctaata aaacaatcta 81360 tgcagaaaca gttatgaatg cagacgacat taaagtatct aataatgcta gtgctgaaac 81420 tagagtatac tttgatgacc ctatgatggc tgagggcggt aaagaatacg ctattgttat 81480 tattactgag aacagtgatt atacaatgtg ggtaggtact agaactaagc ctaagattga 81540 taaacctaac gaggttatct caggtaaccc ttacattcaa ggtgtattat tcagttcatc 81600 aaacgcatca acatggactc ctcaccaaaa ctctgacctt aaatttggta tttatacttc 81660 taaatttaat gagacagcaa caattgaatt cgaaccaatt aaagatgtat ctgcagatag 81720 aatagttctt atgtctacgt acttaactcc tgagagaaca ggatgtacat gggaaatgaa 81780 attaattcta gacgatatgg catcttctac aacattcgac caattgaaat gggagcctat 81840 cggtaactat caagacttag atgttttagg tttagcaaga caagttaaat taagagcaac 81900 tttcgaatca aatagatata tctcaccatt aatgagctct agtgatttaa cattcactac 81960 gttcctaaca gaattaacag gttcatatgt tggtagagct attgatatga cagaggctcc 82020 ttacaataca gtaagattta gttatgaagc tttcttacct aaaggtacta aagttgttcc 82080 taagtattct acagatgatg gtaaaacgtg gaatacattt actaaacctg ctacaactac 82140 tagagctaac aatgaattta cacgatacac tattgatgaa aaagtaaact caaaaacaac 82200 taatactaaa ctacaagtta gattagactt atcaactgaa aatagctttt tacgtcctcg 82260 tgttcgtaga cttatggtta ctactaggga tgaataaact agaggggttg attgacccct 82320 ctttatttaa taaggagaga tttatatgcc tagagaagtt agagaccctt actctcaagc 82380 taagctgttt attcctacag ttgaagagaa atcaattaag gaattagaaa gaacatataa 82440 ggaaaaaatt aatgaagttg atagacttct taatgaatta aagaaagaga gaggagaaaa 82500 atagatggca tttaactaca cgcctcttac tgaaacacaa aagttaaagg atatgtatcc 82560 gaaggtaaat gatataggta acttcttaaa aacagaggtt aatcttagtg atttaaaagt 82620 aataagtggt gttgatttta ataatattct agacaagatt cctgacagcg gtaactatta 82680 tgtaacaact tctaaaaacc aaccaccagg aacaaattgg aatggttttg taagattaga 82740 taaaagagat aaatcatatt acaaaatata ttattcacct tttaatagta ataaaatgta 82800 tataaagact tatgctaatg gaacagtata tgattggatt agttttaaat tagatgaagg 82860 taatttatat aatgaaggta atactttaaa tgttaaagaa cttaatgaat ctacaataca 82920 gtacgcaaca ttagttaatc ccccaaaaga aaatttaaat acaggatggg ttaattataa 82980 ggaaagtaaa aatggtgtat catctttagt agagtttaat cctattaatt ctacatctac 83040 atttaaaatg gtaagaaaac ttcccgtaca agaacaaaac cctaatttac taagagatag 83100 tttatttgtt taccctgaaa caagtatttc taatattaaa acggataatt ggactgcacc 83160 accattttgg gggtattctt ctaatagtgg acgttccggg gttagattta gaggagaaaa 83220 tactgtacaa atagatgatg ggtctgctac ttaccctaca gcaatgacta atagatttaa 83280 aatgggtaaa gagctttctg taggagatac tataactgtg tcagtatatg ctaaaattaa 83340 tgaccctgct ttacttaaag acaacatagt ttattttgaa ctggcaggat atgatactgt 83400 agatagaaca gataaccctt atacaggtgg acgaagagag ataacagcaa gtgaaataac 83460 tactgaatgg aagaagtatt catttacatt tacaatacct gaaaatacaa ttggtgcatc 83520 aggtaataag ataaactata tatctctact actacgaatg aattgttcat ctagtagagg 83580 taacggagcg gtagtatact acgctctacc taaactagag aagtcatcta aagttacccc 83640 ttttataact catgtaaaag atgtaaggaa atatgatgaa atatggtcta actggcaaga 83700 agttattagt aaagacgagt taaaaagtca ctcccctgta gatattgaat ataatgatta 83760 cttcaagtac caatggtgga aatcagaagt taatgagaaa accctaaaag atttagctat 83820 gactgtacca caaggttacc atactttcta ttgtcagggt tctattgaag ggacaccgaa 83880 aggacgttct attagaggaa ctattcacgt ggattatgat aaaggtgacc catataaagc 83940 taataagttt attaagttat tatttacaga tacagaaggt ataccttata cactatacta 84000 tggtggttat aatcaaggat ggaagacttt aaaacaatca gagacttcta ctttactatg 84060 ggaaggtgct ttagattttg gttctaccga atctgttagt ttaaacgatt cattggataa 84120 ctatgattta attgaggtaa cctattggac tcgttcagca ggacattttg ctacaaaaag 84180 attagatata acaaatacat cacatatatt gtatgttagg gattttaata tggcaaacga 84240 tagtacgggt tctagtatag acttttttga aggttactgt actttcccta ctagaacatc 84300 agtacaacct ggtatggtaa aatctataac tttagacggg tctacaaata caacaaaagt 84360 agcatcttgg aatgaaaagg gacgtataaa gatatatact attatgggaa ttaatagagg 84420 ataaaaaagg aggaataaaa actatggctg ttagacatga tataagtagt aacgatatag 84480 tattgcattt aagagaaggt aaatatatta caggatttac aacagtggga ggttatgacg 84540 aggaactagg acaggtaaaa gttaatagag aaattttacc tgcttatttc tttgataatt 84600 ttgcctatga aagatacttg tattatagca aaccggagga agttatagag aataaaaatt 84660 atgaaccacc taaaattaat gatgatgagg gagaatctca acaaaatact gtacctaaag 84720 aacaatatga tagtttaaaa gaagagctag aacttatgaa acagaaacaa gaagctatga 84780 tgaaaatgct tcaacaactc ttaggtcaaa aggggtaata ataaatggca ttaaatttta 84840 ctacaataac ggaaaacaat gttattagag acctgactat tcaggtcaat aacattggag 84900 aagaattaac aaaagaaaga aatatatttg acattacgga tgatttagtt tataatttta 84960 ataaatcaca aaaagttaaa ttaacagatg ataaagggtt agctaaagta tataggagta 85020 caactgttct tagagatata aaagaaccag ggtattatta tataaatgca agagcattag 85080 caatgatgac agataaacct gatatggaat caatagatgt tttactttat gtaatgcctt 85140 tagaatcctc tgatagagtg gtacagcact tgtataccct ctctaccaat aataatcaga 85200 ttagaaccat gtatagatat gtttcaggta actcaagttc agaatggcaa tttattcaag 85260 gactaccaag taataaaaat tctattatat caggctctaa tatagatgat ttaacttctc 85320 caggtgtata ctttgtgaca ggtatgacag gaggtatgcc tagtggtgta gattcaggtt 85380 ttttagattt aagtatagat gctaatgata atagattagc taaattaact gattctgaaa 85440 caggtaaaga atacactagt attaaaaaac ctataggtgt atatacagag tggaaaaaag 85500 aattagagcc aaaagatatg caaaaatatt tattgagtaa tatagaagat gatggtagat 85560 taacatttcc attaatggtt tatgcctcag acaataagac attccaacaa gctgttgtag 85620 accacataga cagaacagga caaacaacct ttacttttta cgttcaagga ggagtaactg 85680 gttcacctat gcctaatagt tgtcgtggat tattcatctc agatacatct aacactgaca 85740 gtctacatgg tatttataat gcagtaggga cagatggtcg ggatgtaaca ggttcagtag 85800 tagggagtac ttgggtttcc ccgaaaacag ccccatccta taaagaatta tggacgggag 85860 cacaatcatt ctcatctaca ggtaccacta agaatctagc ggatgacatt agtaattatt 85920 cttatgtaga ggtttatact aaacataaga cagcagagaa gactaaaggt aatgatgatt 85980 caggtacaat ttgtcataaa ttctacttgg atggtagtgg tacctacgtt tgctcaggaa 86040 cttttgtttc aggagataga acagatacaa aaccacccat tacagagttc tatagagtag 86100 gtattaactt ctcaggaaca acttggaaaa ttgtagatag tgcagtacaa aatagtaaaa 86160 ctcaatatgt tacaagaatt ataggtatta atatgccata gactaggaaa ataatcctag 86220 tctttttttc ttgacttaat aagtattcta tggtatacta taactcgtgt aaggatataa 86280 ggagattaaa atgagattaa gaattaagaa cttatatacc tatgtagaat ttgaggagga 86340 tgataaatac ttaaaagata tatttttaaa gagagttcat actactatag gagcaagaca 86400 agagggattc cagtatagtc ctgcttacaa aagaggtagt tgggatggtt atgtagactt 86460 ttatgtctat gaagaagata agttccctac tggactttta tttaaagttg agttattatt 86520 aggtgagtta caatcaagat ataacttcca gtttgaaacg attgatgagc gtgatgagag 86580 tttcttagct gaagaagata ttgatgatga gataacatta cttgataata atattggtca 86640 aattacttta agagactatc aatacgaggc agtttacaat agcctaacat tctataatgg 86700 tattgctcac ttagccacta atggcgggaa aacagaagtt gctagtggta ttatagacca 86760 actgttacct caattagaaa aaggtgaaag ggtagcattt ttcacaggct ctacagagat 86820 attccatcaa tctgcagaca ggttaaaaga acgactaaat attcctatcg gtaaagtagg 86880 agcaggtaaa tttgatgtta agcaggttac agttgtaatg atacctacat taaatgcaaa 86940 tcttaaagac ccgacacaag gagttaaggt tacacctaaa caaaatatta gtaaaaagat 87000 tgctcaagag atattaccta aatttgaagg tggtaccaat caaaagaaat tacttaaagt 87060 attacttgat aatacaacac ctaaaacaaa ggtagagcaa aatgtattaa atgttttaga 87120 actaatttac caaaacagta aaactgatgc agaggtctta ttaaacctaa agaaacataa 87180 tgctcatttc caaaaagttg ttagagaaaa gaatgaaaag aaatacgata aataccaaga 87240 tatgagagac ttcttagatt cagtgactgt tatgatagtt gatgaagcac accactctaa 87300 atcagactca tggtataata atctaatgac atgtgaaaaa gctttgtata ggattgcact 87360 aacaggttct atagataaga aagatgaatt actatggatg agactgcaag ctttatttgg 87420 taatgttata gctagaacta ctaataagtt cttgattgac gaaggacatt ctgctagacc 87480 aacaataaat attatacctg tagctaatcc taatgatata gatagaattg atgattatag 87540 ggaagcttat gataaaggta taacaaataa tgattttagg aataaactta ttgcaaaact 87600 aacagaaaag tggtataatc aagataaagg aacattaata attgtaaact tcatagaaca 87660 cggagataca atatctgaga tgttaaatga tttagatgta gaacactact tcttacatgg 87720 agaaatagac tctgatacta gaagagaaaa actaaatgac atgagaagtg gtaaacttaa 87780 agtaatgata gctacatcac ttattgatga gggtgtagat atatcaggta ttaatgcact 87840 aatactaggt gcaggaggta aatcattaag acagacacta caacgtatcg gacgtgcttt 87900 acgtaagaag aaagatgaca atactacaca aatatttgat tttaatgata tgacaaatag 87960 atttttatat actcatgcta atgagcgtag gaaaatttat gaagaggaag attttgaaat 88020 aaaagactta ggaaaatagg agggtaagag atggcaacaa aaacacaaag aaagttatac 88080 caatatctag aagaaaatgc tacagaaaat aaatttcata tttctactaa gaaagagcta 88140 gcggattctc tagacgtttc catctctgct ttatccaata accttaaaaa gttagaagaa 88200 gaaaataaaa ttgttactgt atctaaaaga ggtaaaaatg gtggcgtagt gataacttta 88260 gtgagagact ataatactga agagttaaaa gagtttaatg aatctaaaga taacattatc 88320 acttcaaact tacaatatgc caaagaactt agagagaaac atttcccttc atatagatac 88380 gagagaaaag aacagcgtag acgtactaag atagaaatgg ctcagtacaa cgccattaag 88440 gatgagaaga gaagaatcat agcagatatg aactttcatt cagaaggtct ttcttaccct 88500 tctaaagata tatttaatat gtcttatgac ccggaaggat tctataaagc atatatactt 88560 tgtaagcttt atgaccaata cgctatctct catatggatg ccaaacatac gagtcatctt 88620 aaagcaatga gtaaagcaaa aactaaagat gaatatgatt accatcaaca tatgtctgag 88680 tactatagaa ataaaatgat tcagaactta cctagaaata gtgtaagtga taatttcttt 88740 ggtagtaaaa catttaatac cttttataat ttttatttaa aaataaaaga taaaaatatt 88800 aatgtattta aatatatgca aaacgtgttt aagaatgtaa cattttatta tgagaatggt 88860 atgcacccta atccaatacc ttctcctaac ttctttagtt cagataagta ttttaaaaac 88920 tataataatt atattaaagg aataaaaaaa ggtgttaaca ataccaacag acacctagga 88980 gatacagata gtattattaa ttcttcagac tatgtgaaga atcctgctgt attacattta 89040 catcagttat atactacagg attaaattct accctacatg atattgatac aatgtttgaa 89100 caagccttag acctagagaa tgcttcttac ggattatttg gaaatatgaa acatattgta 89160 ttactgcaat ataattctat gattgaagag gaagttaaga atttacctga agaagaaaga 89220 ggtattatta ataaatatgt aaaacaatgt ataattaatg aatattcacc gacaagtata 89280 tcaccttcag caagattatc aatgttcact atgcagaaag agtatattgt tcatgataga 89340 caattaaata atggtattaa acgagaagat ttactaccat taagcttagg tggtagagtg 89400 gataaagatt cacttagtgg aatggatata caaaacctag aacagaacgg taatgagtac 89460 ctttatatga gacagtatac ttctacttat tatatactaa gaatgtttgg agattattta 89520 ggctatgaag taaacttaag agaagtaaaa tatattgtag agaaatataa tttaattgat 89580 aaaataccct tgacaaaaga aggtatgttg gattataata aacttataca tttagtagag 89640 gaagaggtta ataactatga gtaaaaagat aaaggagctt attcttcata aatcaatgaa 89700 ggatatacat tttgcaagag aagtattaga taacttacct aagaacctat tctcagcaga 89760 gtctgaggat atgggttact tatttacagc tataaagaga acagcacaca tttccgataa 89820 gatgtctaat gaagcattag caattaaagt agaacagctt atgggtaata ataaggaaga 89880 tgaagagaga gtaactaaaa ctttaactta cttagaagat ttatacaaag tagatgttaa 89940 tgagaaagat gagtctgtta actatgaaat agaaaagtat attaaaacag aaatgtctaa 90000 ggaagtatta gttaagttta tagcagaaaa taaacaagaa gactcagaca acttacatga 90060 gcttgtagat aaattaaaac aaatagaggt aagtgatatt tcaggaggca acggggaatt 90120 tattgatttc ttcgaagata ctgaaaagaa acaggaacta ttaagtaatt tagctacaaa 90180 taaattctct acaggcttta cttccattga taatcacatt gaaggtggta tagcaagagg 90240 agaggttgga ttaattatag ctccaacagg tagaggtaag tcattaatgg cttctaactt 90300 agctaaaaac tatgtgaaga gtgggttaag tgtcttatat attgcattag aggaaaaaat 90360 ggatagaatg gttttacgtg cagaacaaca aatggcaggt gtagagaaaa accaactagt 90420 aaaccaggat atgtctttaa atagtaaagt ttatggtgcc ttacaaaatc attatcagaa 90480 gaatagaaag ttattaggtg acttttatat ttctaaacac atgccaggtg aagttacacc 90540 aaaccaatta gagcaaatta ttgttaatac tacaattaag aaagataaga atattgatgt 90600 tgttatcatt gactaccctc atctaatgag aaacccttat gctaagtatc actcagaatc 90660 agatgcagga ggaaaactgt ttgaagatat tcgtagatta tcacaacagt atgggtttgt 90720 atgttggact ttagctcaga ccaaccgtgg agcttatggt tcagatgtca ttacaagtga 90780 gcatgtagaa ggttctcgta agattgtcaa tgctgttgag gtatcattag cagtaaacca 90840 aaaagatgaa gaattcaaga gtggtttctt aagattatat ttagataaaa tccgtaacag 90900 ctctaacaca ggagaacgat ttgttaatct taaagtagaa ccaactaaga tgattgtaag 90960 agatgagact cctgaagaga aacaagaaca tattcaattg ttatctgata atgggaaaga 91020 agatacaagt aagtttaaag ataaagataa taaaatagaa gctataaata acacattcgg 91080 aggattacct ggaatttaaa tttttaacct ataccacttg acattttata tgttaggtgg 91140 tataattgtt ttataaacaa aaaaggagag atttataatg agaaatttag acccaataat 91200 taactttaga ttttttaata atagtaaacc cgaaggatat gtaatatttt taacaagtga 91260 gacagaaact agagggatga caattgaagt agcaagccct caagatagag tgtttgagct 91320 tgaatataaa ccaaatacaa ttattttgac agataacaat aataaaacaa ctacttatgt 91380 aaacgatgta gaaacttcat ctgaagaaat agaaaaacac ataaataaac ttattgaaga 91440 ggatttggag gatgaataat gaaatttata tttttcacag atagtcattt tcatttattt 91500 acaaactatg caaaacctga tgaattttat tataatgaca gatttagaga acagatagaa 91560 gcgttacagg aagttttcaa tatagctaag gaagaggaag ctattgttat ctttggagga 91620 gacttatttc ataaacgtaa tgctgtagat acaagagtgt ataatgaagt atttaaagta 91680 tttgctagaa ataaggatgt agctgtttta atgcttagag gtaatcacga tgccacaact 91740 aactcaatat atacagattc aagtatagat acttttaatt acttacctaa tgtaactgta 91800 tttacagctt ttggtgcaat tgaaaagaac aacgtaaata tagtattcac agcttatgga 91860 gatgaaacag aagagattaa agagtatatc aaaagtaatg ttcaggaaga taaggttaat 91920 gtacttgtag ggcatttagg tgtagaaggg tcattaactg gtaaaggttc tcatagatta 91980 gaaggagcct ttggatatca ggacttatta cctgataaat atgatttcat tttattaggt 92040 cattatcatc gtagacaata tttccaaaac ccgaaccatt tttatggggg ctcattaatg 92100 caacagtcat tttctgatga gcaggaagct aatggtgttc acctaataga tacggaaaag 92160 atgactacag aatttattcc aatccataca cgtagattta ttactatcca gggagaagat 92220 atacctgaaa actttgacca attagtagat gaagataatt ttattagact tattggtact 92280 tcaaaccatg ctaaggtttt agaaatggat gagaacatga gagacaaaaa tgttgaagtt 92340 cagattaaaa aagagtatac tgtagaaaaa cgtatagaga gtgacgtatc tgatgaccct 92400 ttaacaattg ctagtactta cgctaagcag tattcacccg aatcagaaca agaaatactt 92460 gaatgcttga aggaggtttt atagtgagaa aatataaaga atatctaaac aagtcagatg 92520 aagaaaattt agcagaagac tgggaacgga taaaagaaga tttatggaaa gtgtttaaag 92580 atatgaaacc taaaattaat acattagaca tcagtaatgt agtgagtaaa gatttagata 92640 aaagtaaacc tattttacaa tttcaagatt cagacagagt agtagagaat atttgtaatg 92700 ttgaaggttt agaagatggt ttatctaaaa tgaaaaagat ttttgacgat agtaattttg 92760 acaaacatta ctataataga attgtagaac atgatgaata ttattggatt gattatggtt 92820 ctcatcattg tttctttagg gttacgaaag gagataagta atggtagtat ttaaacaagt 92880 agaagttaat aattttttag caattaaaga ggctacatta gagttagata atagaggttt 92940 aatacttatt gaaggagaaa ataaatctaa cgagtcattc cattcaaatg gctccggtaa 93000 gtcaacttta atatctgcca ttacttatgc tttatatggt aaaactgaaa aagggttaaa 93060 agcagatgat gtagtaaata atattgagaa gaaaaataca tctgttaaac ttaagtttga 93120 tattggagaa gatagctatt taattgagcg ttatcgtaaa gataaagaga ataagaacaa 93180 agttaaattg tttgttaatg ataacgaaat tacaggttca acaaatgatg ttaccgataa 93240 gcagatacag gatttatttg gtattgagtt taatacgtat gttaatgcta tcatgtacgg 93300 tcagggagat attcctatgt tctctcaagc aacagataaa ggtaagaaag aaattcttga 93360 atccattact aaaacagatg tatataagca agcacaagat gtagcaaaag agaaagttaa 93420 agaagtagaa gaacaacaga ataccctaag acaagaaata gataaattag ggtatcagtt 93480 atctacaaaa gatgaatact ttaaaaagga agtagaacag tataatcaat ataaagaaca 93540 attggttcag atagaaaaca gtaataaaga gaaagataga ttaagagagc aagaagagaa 93600 gcaaatagaa gctcaaatag agcaattaac ttcacaggta ccaacaatac ctgatgaaca 93660 atttaatcac tcggaggact ataataaagc ctctcagagc ttagatttac tttctaataa 93720 attaactgaa ttaaatcaag tatatacaga ttataatact aaggagcagg tattaaaatc 93780 tgagataact acactaaata atagtttaaa tcagttagat acaaacgacc attgtcctgt 93840 ttgtggttct cctatagata actctcataa acttaaagag caggaaaata tcaataatca 93900 gattgaacgt aagaaacaag aaattactag tttattagga acgaaagata cgtacaaaga 93960 agctattgat aaagtaaata ataaagcaca agaaattaaa gacaagatgt cccaagaaga 94020 ccaacaagaa cgagagtata ataataagat taatagactc attcaagagg cttctaagat 94080 taaatcagat attagttcat tagagaataa taaaacctat ttaaaagtga aatatcagca 94140 tcaatctgtt caaggtttag aacgagaaga accaagcaaa gaaaaacatg aagaagataa 94200 aaaagaattg caaaatgcta ttgacaaaca tgaagaaaat gtagtacaat tagaaagtaa 94260 gaaaggtaag tatcaacaag ctgtagatgc ttttagtaat aaaggtatac gttcagtagt 94320 gttagacttt attacacctt tcttaaatga gaaagctaat gaatatcttc aaactttatc 94380 aggttcagat attgaaatag aattccaaac tcaggtgaag aatgctaaag gagaactaaa 94440 agataagttt gatgttattg ttaagaatag taagggcgga ggctcgtata aatcaaactc 94500 agcaggagaa caaaaacgta ttgacctagc aattagtttt gcaattcagg atttaattat 94560 gagtaaagat gagatatcta caaatattgc actttatgat gaatgttttg atgggttaga 94620 tactgtagga tgtgaaaatg taattaagtt attaaaggat agacttaata cagtaggaac 94680 tatatttgta attacccata accaaagttt agctccttta tttgagcaaa caattaaaat 94740 aataaaagaa aatggagtat caaaactgga ggaaaaataa tgaaattaaa gattttagat 94800 aaggataatg caacacttaa tgtgtttcat cgtaacaagg agcacaaaac gatagataat 94860 gtacctactg ctaacttagt tgattggtac cctttgagta atgcttatga atataagtta 94920 agcagaaatg gagaatattt agaattaaag agattacgtt ctactttacc ttcgtcttac 94980 ggtttagaaa gtaatgacca ggatattatt agagataata atcatagatg tagaataggg 95040 tattggtata accctgcagt acgtaaagat aacttaaaga ttattgagaa agctaaacaa 95100 tatggtttac ctgttataac agaagagtat gatgctaaca ttgtagaaca agggttcaga 95160 gatattggag ttatattcca aagtcttaaa actattgtcg ttactaggta cctggaaggt 95220 aaaacagaag aagaattaag aatttttaac atgaaatcgg aagagtcaca attaaatgaa 95280 gcacttaaag agagtgattt ttctgtagac ttaacttaca gtgacttagg acaaatttac 95340 aatatgttac tattgatgaa aaaaattagt aaatagtaag gaaggatatt atgaggtttg 95400 aagacttttt aacccaagaa ttaggagaac caaaagagaa tactataggt gagctaagat 95460 actgttgtcc gttttgtgga gaaaaaagtt ataagttcta tgttaagcaa gctttagact 95520 ctagtaatgg tcaatatcac tgtaaaaaat gtgatgaatc gggaaaccct attacattta 95580 tgaagaccta ttacaacatt acaggtaaac aagcttttga tttattagag tctaagaaca 95640 tagatataga gagagcccct ttacttacaa ctaataacaa ggatttaaca gaatcagaga 95700 aacttatatt aatgcttaga ggagtacatc aagatagagg aaatacaagt attaaaccac 95760 ctagattacc taatggatat aagttattaa aagataattt aaataataga gagattatac 95820 cttttctaaa atacttaaaa ggtagaggta taactttaga gcaaatcatt aataataata 95880 taggttatgt tactaacggg agcttctata aagttgatgg agaatcaaaa gtatcattaa 95940 ggaatagtat tatattcttt acgtatgata atgatgggaa ctatcaatat tggaacacac 96000 gaagtataga gaaaaacccc tatattaaat ctattaatgc tcctgctaaa caagatgaag 96060 taggaagaaa agatgtcata tttaatttaa atatagcaag aaagaaaaaa ttcttagtta 96120 taactgaagg tgtatttgat gctttaacct ttcatgaata tggagtagca acactaggta 96180 aacaagtaac agaaaatcaa ataaaaaaaa taattgatta tgttagtgta gacacatcaa 96240 tatatattat gttagatact gatgcattag ataataatat agatttagct tataagctca 96300 aaacacactt taataaagtt tactttgtac ctcatggtga cgaggatgca aatgatatgg 96360 gaacaaggaa agcttttgag ttgttaaaac agaatcgagt actagtaaca cctgaaagta 96420 tacaaagtta caaaatacaa caaaaactta aactttaggc ttgaccttag aagagtttta 96480 tgttatacta gtacttaagt aattaataaa ggagaaaaaa ataatgtcaa ataataaaaa 96540 agatatttta gaatttgtag atgaatacat tacagcttta agagttggta atgagcaacg 96600 acaacatcaa ttagaagaaa taggtaaaga agaaacagca acattaacag acgtaactaa 96660 agctattact aatcttatgt taggtgttaa tgagcaaatg acagacttag aatacaacaa 96720 tgagttaaac ttaaatattt taattgatgc tttatataaa gcagagctta ttaatgaaga 96780 tgtattaggc tacattcaag aatcaattga taaatcacaa gaagaaccta aaaatgaaga 96840 agaaaaagga gaacaagaat aatggaaaaa aatattagca cacacacaaa aggtattagt 96900 caagcagaca tggagaaatg gattgaagct gtagtacaag gaactgttga tggtaaacaa 96960 gttgatgaaa aaacagctaa acaattagat agaattggtt cacgtagtgt ttctttagaa 97020 gaagcaactc gtattgctaa agtacttaat gctgttacag ttcaagagat ttcaggagat 97080 tttaatgatg catttaatgc aattgactta atgatgatta tcatggaaga tgagttagga 97140 gtaactcaag aacaagttga aaaagctaag aataagttaa atgataaacg agaagcttat 97200 ttaaaagaga agcaagaaga attacgtcaa aaacaacaag aagaagtaca agaagaaact 97260 gaatctgaca gcaatgaaaa agtaattcag ttgaagaaaa atgacgaaca gtaagaaaaa 97320 aggagataca ttcgaacgta aaatagctaa agaattaact gcttggtggg gatatcaatt 97380 taataggtct ccccaatcag gtggtgcctc ttggggtaaa gataataatg ctgtcggaga 97440 tatagtagta cctcaggaag ctaattttcc tttagtagta gaatgtaaac atagagaaga 97500 atggactata gataatgttc ttctaaacaa tagagagcca catacatggt gggaacaagt 97560 aatcaatgat agtagtaagg tgaataaaac accttgctta atatttacta gaaatagagc 97620 tcagagttat gttgctttac cttatgatga aaaagtatat gaggacttaa gagataatga 97680 atatcctgtt atgagaacag attttattat tgataatatt agaaaagata aattttttta 97740 tgatgtcctt ataactacca tgagtgggtt gacctcattt acaccttctt atattatatc 97800 ttgctacgac aaaaaagatg taaaaccata caagaaggtc gagtctaatt tatctgaggt 97860 aagtaaacat gaagatgaat tgattaatga ccttcttagt gatatataag gaaggtaaga 97920 taagtatgac gagtaaagaa agaccattaa ttgtatattt ttcaggtaca ggacaaacag 97980 aaagactagt aagcaaaatt aatattaata attcatttga aacgtttaga gttaagagtg 98040 gaaaagagaa agtagataaa ccttttatac taataacacc tacttatatg aaaggtgcaa 98100 tacctaaaca aatagaaaga ttcctagaaa ttaatgggag ccctaaagaa gttattggaa 98160 caggaaataa acaatggggc tctaatttct gtggagcaag taaaaagatt tcagagatgt 98220 ttaagattcc tttaattgct aaagtagagc aatcaggaca ctttaacgag atacaaccaa 98280 tattagaaca ctttagtaat aaatacaaag tagcgtaaag gatgagagat atatggcaac 98340 atatggaaaa tggattgagt taaataacga gataactcaa ttagatgata atggaaaaaa 98400 taaactctat aaagaccaag aagctttaga tgagtattta aaatacattg aagataatac 98460 aagaaaattt aatagtgcag tagagagaat tagagtattg acagaagaag gaacttatga 98520 taagatattt gatagtgttc ctgatactat tattgatgaa atgactaagt tagcttatag 98580 ctttaacttt aagttcccta gtttcatggc agggcagaag ttttatgagt cttacgcatc 98640 aaaacagtat gatgaaaatg agaaacctat ttttgttgaa gactatgagc aacataacgt 98700 tcgagtagct ttatacctat tccaaaatga ttatgtaaaa gctagagaat tattgattca 98760 gctcatggaa cagacattcc aaccatctac accaacttat aacaactcag gacaagctaa 98820 tagaggtgaa ctaagttcat gttatctatt tgtagtagat gattcaattg agtctctaaa 98880 ttttgttgaa gatagtgtag ctaacgctag ttctaatggt ggcggagttg caattgactt 98940 aactagaatt agacctaaag gtgctccagt acgtaataga cctaactcaa gtaaaggtgt 99000 tattgctttt gctaaagcta ttgagcataa agtaggtatt tatgaccaag gtggagttag 99060 acaaggtagt ggtgcagtat accttaatat tttccataat gatattttgg atttattaag 99120 ttctaagaaa attaatgcca gtgaatcagt tagattagac aaattatcta ttggcgttac 99180 aattcctaat aaatttatgg aattagttaa agaaggtaaa cctttctata cttttgacac 99240 ttatgatact aataaagtat acggtaagta tctagatgaa ttaaacattg atgaatggta 99300 cgaagaacta ctaactaatg ataagattgg taaagtaaaa catgatgcta gagaagtcat 99360 gacagatatt gctaaaactc aattagaatc aggttaccct tatgtattct atgttgataa 99420 tgctaatgat aaccaccctc ttaaaaactt aggtaaagtt aaaatgagta acttgtgtaa 99480 acaaatgcac ctttaacgag taatcgttat cgaaaaatcc atctaaaacg gggaagccta 99540 cgtcaaatga tatggtaatc cgttgctaaa tatataaatt gtaatcactc ataggagagt 99600 gatattatgg aaaataaacc tataggagct gtttatgtta ctacatgctc tgtaaatggt 99660 aaaaagtaca ttggaaaatt tctttatgat agaataaatg actgggaaaa gtacttaggt 99720 tctggtagat acctacaaga agacattaag aagtatggta aagataagtt tattaaagaa 99780 attataaaaa attactatac gacagaagaa ttagaaaagg ctgaagaaga attaatatta 99840 aaaaccaatg cagtttatga tgacaactac tataatgtaa aactatcttc cgtaggagga 99900 gacatattca caacaaaccc tcgaaaagaa gaacttagag agatgagaaa acaacaaatg 99960 agcggtcaag gtaatcatca gtatggtaaa cctaaaacag aaaagatgat aagctctgta 100020 aagaaagcta actctagagc aatagagata gatggtataa aatatgagag cacatccaag 100080 gcatctagaa ctttaggtat aggacataca acaattggtt atagattaga ttctgataat 100140 taccctgagt ataaaaggtt aacacctaga aaatttgaaa agaaatgatt acaatttata 100200 ttaaatgccc aacgactatc tgtaacctat tcacataagt gaagggataa ggttagagcc 100260 aagtggtcaa ggtatcgagt aataatcgtg taaatccttg ttaaatcgaa acggtggact 100320 tcctataagg aagaatgata tagtctactc tatatggaaa catatagcag tcttaataga 100380 agacggacaa tgattaacga ccattgttga atatacagga cagaaatttc acaattacaa 100440 gaggtatcag agatacaccc ttatgcatac agcaatcaga atgttattaa tagagatgtt 100500 gtttgtacat taggttcact taacttagtt aatgtagttg aaaaaggttt attaaatgaa 100560 tctgtagata tcggaacaag agcattaact caagttactg atattatgga tttaccgtac 100620 ctacctagtg ttcaaaaagc aaatgatgac attagagcta tcggtttagg ttcaatgaat 100680 ttacatggac ttttagctaa gaatatgatt agttacggtt ctagagaagc attagaccta 100740 gtaaatagtt tatatagtgc tattaacttc caatctatta aaacatctat gttaatggct 100800 aaagaaacag gtaaaccatt taaagggttt gaaaagtctg attatgctac aggtgaatac 100860 tttgtaagat atattagaga gtctaaccaa cctaaaacag aaaaagctaa gaaagtatta 100920 agtaaagttt atattccaac tcaagatgat tgggatgaat tagctaaagc agttaaggtt 100980 catggattgt ataatgggta tagaaaagct gaagcaccta ctcaatctat atcatatgta 101040 cagaacgcta caagctcaat tatgcctgta cctagtgcta ttgagaatag acagtacggg 101100 gatatggaaa catactaccc aatgccttat ctaagcccta taactcaatt cttctatgaa 101160 ggagaaacag cttataagat tgataataaa cgtattatta atacaagtgc agtagttcag 101220 aagcacacag accaagcagt atctactatt ctttatgtag agtcagagat accgactaat 101280 aagttagtat cattatacta ctatgcttgg gaacaaggat taaaatcact atactacaca 101340 cgttcacgta aactttctgt tattgaatgt gaaacatgtt cggtttagaa aggaaataga 101400 tatggatatt acacaaaagg taaaacaaca taataaaaat gcagtattaa aagcaacaaa 101460 ctggaatatt gaagatgacg ggatgtctga tgtattttgg gagcaaggaa tctcccaatt 101520 ttggactcct gaagagtttg atgtatcaag agatttaagt tcttggaaca gtttaactga 101580 gagtgaaaag aacacttata agaaagtcct tgcagggctc acagggctcg atacaaagca 101640 aggaggggaa ggtatgaact tagtatccta tcatgaacca agacctaaat accaagctgt 101700 atttgcgttt atgggtggta tggaagagat acatgccaaa tcctatagtc atatctttac 101760 aacattacta aataacaaag aaacaagtta tttgttagat acttgggttg aagaaaatga 101820 atttttaaaa gtaaaagccc agtttattgg atattattat gaccaattat taaaacctaa 101880 ccctactgta tttgatagat acatggctaa agtagctagt gccttcttag aaagtgcatt 101940 attctactcc ggattctatt accctctact tcttgcagga agaggtcaga tgacacaatc 102000 aggagctatc atttataaga ttactcaaga tgaagcttat cacggttcag cagtaggatt 102060 aacagctcaa tatgattaca accttttaac agaagaagag aaaaaactag cagatagaga 102120 gacttatgaa ttattaaata ttctttatac taatgaagta gcatatacac atagcctata 102180 tgacccatta gaattaagtg aagacgtaat taactatgtt cagtataact ttaatagagc 102240 acttcaaaac ctaggtaaag aagattactt taatcctgaa ccttataacc ctattgtaga 102300 aaatcaaact aatgtagata gattacgaaa tgtagatttc ttcagtggta aagcagacta 102360 tgaaaaatct acaaacatta aggatattaa agatgaagat ttctcattct tagacagtaa 102420 agaatatagt actgctaaag aattcctata aaaaggagaa aagatattat ggatagaaat 102480 gaagcaatgg atttactaag caaaacagaa acactattta aaaaacatga tgagttttca 102540 tgtgtaagtg atatcaatga ccctatgaag ttattcagca actctaaaga tgctaaagct 102600 gatgacactt ctaagtcatt tcagttagag tttatgcatg atatgacgat gtacacttta 102660 tcctatggct caggtcaatt aaaacttatt gacctagcag aaggatatga agcacagaaa 102720 gcaacagtag ttaactcatt tcccgaaatt attaaaacat tagaaaagga tgattcagaa 102780 gatggaaaaa atggatagtt tagtagactt aaatacagca attagacaaa agaaagatgt 102840 tattgtaatg attacacagg ataattgtgg taaatgtgaa attttaaaaa gtgtaatccc 102900 tatgttccaa gaatcaggag atatcaataa acctatcttg acacttaatt tagatgcaga 102960 agatgtagat agagagaaag cagttaagat ttttgatatt atgagtactc cagtgttaat 103020 cggatataaa gacggagagc tagttaagaa atatgaagac caagtgacac caatgcaatt 103080 acaagaatta gagtcacttt aatttgtaat ttcctgctat ctgtgctata ctataatagt 103140 acaaggtagt aggatttttt tttaatgaaa ggaagatgac atatcgcaaa gaataaaaca 103200 ttaacgatat acaatagtga cagatatttt aatatacaca caaaagataa agataaaatt 103260 aatgaggcta ttaaagtaac acacagtaat gaagaagaga ttgaaaagga tatggacgag 103320 ctaatatcta aatctagacg atacgtcatg agagatgaaa atcattatat gttatttaat 103380 gagaaataca ataatgatag acttatagag aaggtatgta aacacggtgg taaaattaca 103440 tactatacag attcagtatt accctattat gtattaaaag atttatctag ccatcctgat 103500 tcagaggttg tttatcgtat gcgtaatggt tttactgcaa aagaggtaga taatatagct 103560 ctatcattca tgggaacaaa agttattatt gatatttcag tggtatttcc gtatgtaaac 103620 ccttatgata ttattagaag cttacatgat attaaaacaa acgtagatga agttcattta 103680 tcattcccac gtatactaga agtagatgaa aaacaagaaa aattctattt ctttgatgga 103740 gaagcttatg atttaaaacc tgaatataaa gtcgattttg cagataaaat tagagtatcc 103800 ttatcagtat ggaaaatgta tatctatatc ttaacaggta gtcgtgattt tgaagatgta 103860 gacgatgtaa ttacgaaact gaaacaacaa cgaaagatta agatataagg tgattatatg 103920 agtacagcaa atagaagaga tatagcaaga aagatatcag agaatacagg gtattatatt 103980 caagatgtag aagaaatact aagtgcagag acagatgcta tttcagactt attagaagaa 104040 gggtatacta aagtaaagaa ccataagttt ctgcaaatag aggttattga aagaaaaggt 104100 aaaaaagcat gggatggtct gaataaagaa tatttccatt tacctgatag aaaagctata 104160 aaatttaagc cacttaaaga actagaagag gttattgata gacttaatga agaagagaaa 104220 taattctctt ctttttttat tgacagggtt taaaatatat gatatagtat tattaagtta 104280 aaaaaggaga ggaactaaat gaaagtatta atcttattcg accacattag agaagaacac 104340 ttttctgtaa gtaaagatgg gggtgtgaag tctaatgtat taaatacacc taacggaaaa 104400 acacttaaga agttacttga gaagtgttct aacttaaaga gagataaaac aaatagagac 104460 tatgatattg attttcttta taatgcagta cctacaccta ttcgaaatga ttatggtaag 104520 attattaaat atcaggatgt taaacaagca gaagtaaaac catactatga aagaatgaat 104580 aacattatta ttgataatgc ttacgatatg attattcctg taggtaaatt aggagttaaa 104640 tacttattaa atgttacagc tatcggtaaa gtaagaggag taccaagtaa agtaacagtt 104700 gaaaatgaaa catcttctca tgatgtatgg gtattaccta cgtatagtat tgagtatact 104760 aatgtaaata aaaatagtga acgtcatgtt gtatcagatt tacaaacagt aggtaagttt 104820 gtagagcaag gagaagaagc ctttaaacct aaagaagtat cttatgaatt agtagataac 104880 attgaaagag ttagagaaat atttactaag gaagtaacga atgataatta tgatggagta 104940 gatatcactg catgggactt agagactaac tcattgaaac ctgataaaga aggaagtaaa 105000 cctctagtat tatctctatc atggagaaat ggtcaaggtg taactatacc tttatacaaa 105060 tcagacttta gttgggaaaa tggtcaagat gatattgatg aagtattaga gttgtttaag 105120 aattggttag ctagcaaaga agatattaag gtagcacata atggtaagta tgatattaaa 105180 ttcttaatga gtactgagaa ctttaaagat tttgagagta ttcaagatac taaagtaggt 105240 tggtacttag ctgtaacaca agaagttaaa gagtcactaa gattatctga tttagcttat 105300 gaagtaacag atgtaggtgg gtatgataaa cctttagaag actttaaatt atggtttgtt 105360 actaagttac taagattttt ctctgataaa attaaagaaa tacaaaaaga gaataaaaag 105420 gttgctaaga aagaatatga cattaaagct cctgaatata aagagtggtt agataataag 105480 ctagaagaaa ttacagatga gattaagtta gaaaacaaat atactcagtt aggactaaca 105540 cctgaggttg ttaacataga ttgtactatg gaagatgact ttaaggttat tgcagaacaa 105600 tcacctgaat atatgggatt atctaatgaa gctaagtctt acacactaaa tactgcaatt 105660 ggtttaatta ataagtatag agatgtaaaa gatgtagtga atgatattga cggaggtaac 105720 tttaactatg attggttccc tattgaatta atgcatccat acgcatcagg agatacagat 105780 gtatgtagaa gaattcactg tgatgtagtt aagaaattag aagaacaaga tagacctaag 105840 tctatgcatt tattagaagt taattaccct agattaacta aatcactagc tagaatagaa 105900 tcaaatggtt tatactgtga cttagactat atgaaagaaa atgatgagtc atatgagact 105960 gagatggcta agaaccacgc tacaatgaga gaacattggg ctgttaaaga gtttgaagag 106020 tatcagtata acctttacca aatggcgtta gaagagcatg agaagaaacc aaaagaaagg 106080 gacaaagata ttcaccagta tagagataag tttaaagatg gtaaatggat gttttctcct 106140 agttcaggag accataaagg tagagtaatg tatgatattt taggaattca attaccttac 106200 gataaagagt atattaaaga aaaaccattt aacgctaatg ttaaagaagc agaccttact 106260 tggcaggatt ataaaacaga taagaaagct attagttatg cattagataa cttagattta 106320 aaagatgatg ttaaagaact tcttgaatta cttaaatatc atgctagtat gcagacaaaa 106380 cgtaattcat ttactaagaa attacctaat atgattaata aacaaaagag aacattacat 106440 ggttctttct ctgagacagg tacagagaca tcacgattaa gtagtagtaa tcctaactta 106500 caaaacttac cggcacatac gtcagatgta aacaagtttg attataaaca tccgattaaa 106560 cgttcatttg tttctagatt tgaaaacgga gtactactag gagccgacta tagtgcccta 106620 gagatgcgta ttattggatt atttactaaa gacccggata tgctacaatc attcctaaac 106680 ggagaggata tccataaagc tactgcaagt attgtttata acaaaccagt agaagaagta 106740 actaaagaag aaagacaagc aactaaagcg gttaacttcg gattagcctt cggtgaatca 106800 ccattctcat ttgcaggaaa aaacaatatg tcagtagagg aagcagaaga gatatttgaa 106860 aagtacttcc aaactaaacc tagtgtaaaa acttctattg acaatgtaca tgagtttgtg 106920 caacaatatg gttatgttga tacgatgcat ggtcatagac gcttcatccg ttcagctcaa 106980 tcagcagata aaaagataaa aaatgaaggt ctaagacagt catttaatac tattatccaa 107040 ggttcaggta gtttcttaac aaatatgtct ttaacttact tagatgactt tattcaatct 107100 cgtaacttga aatcaaaagt tattgccaca gtacacgata gtatcttaat tgattgtcct 107160 cctgaagagg ctaagattat ggctaaagta acaattcata tcatggaaaa cttaccgttt 107220 gatttcttaa aagcagagat tgatgggaaa gaggtacagt accctattga agctgatatg 107280 gaaattggtt taaactataa cgatatggtg gaatatgacg aagaagaaat agaaacattt 107340 aactcttacc aaggttatat taagtacatg atgaacttac aaacactaga agactataaa 107400 gagtcaggta agttaacaga tgaacaattt gaaaaggcta ctaatgtagt taaaggtgag 107460 aaatctatct atcaagaaat ttaaaaaaag tattgacaaa atgtttaact tatgctatac 107520 taattaagta ataaagataa ggaggaaaaa cagtgaatac aggagaaatt agatttaatc 107580 gttctatgga tgaatggatt ataacaagca tgtatcagaa tgaattaggt gaaatgaata 107640 ttgttgttac attctataat agagaagaaa ataaacatgg ttctacagtc ttaccaacag 107700 agtcatctac tggggaagta acagaggaat tagcaagtct tgaggaagaa taccctttag 107760 ccttaccttt aagtagtatc tcagttaata tttaaaagga ggaactggta aatggaaata 107820 cacattgatt ccctagattt tacaaatttt actattaaag atagaaacgg gaactcacaa 107880 gagtttgata ttacagatga attaaagatt acagaatata cgattcaaga ggactttatg 107940 caacaatcag ctaagtatgc tttttgggct tctatattag agaaggtcag agcatattct 108000 gaaatggaac aacgaaacct agaaacagtt ggtagtaagt taaaccttag aattagacaa 108060 gagtatgaac aacaaggaaa gaaacctact aaagatatga ttgagtctag tgtatatatt 108120 catgactctt accaacaaca gcttaaagtt gttgaggctt ggaattacaa agttaagcaa 108180 cttcaatatg ttgtaaaagc atttgagaca agacgtgaca tgatgataca attaggtgca 108240 gaattaagac agacaaataa aaacggtgga attactaatc cgttttcaca ttaaaaaata 108300 aattaaaaaa tataattgac aaacataaaa aactatgtta tactaaataa gtaaattaat 108360 taaaaggaga aaagataatt atggatttca atcaatttat taacaatgag gcaagcaaat 108420 tagaaagcag taacagttct ttcaacaaca atgtagagag ctataaacct aaaaaccctg 108480 tattacgatt aggtaacgtt aaagatgcaa acggaaataa agttactaaa gaaaatgctt 108540 ttgtacgagt attacctcct gcacaaggaa caaatgtttt ctttaaagaa tttagaacaa 108600 caggtattaa ctactctaag aaagacggtt ctcaaggatt cacaggatta acattacctg 108660 cagaacaagg ttcatcagta cttgaccctt acattgatag ttggatagca aatggtgttc 108720 aattcagtag attccctaat aaacctgcag tacgttatta cattcatgtt attgaatact 108780 ttaataacaa cggacaaatt caacctaaaa cagattcaca aggtaatatc atgattcaac 108840 cgatggaatt atctaacaca ggatataaag agttattagc aaaccttaaa gatactatgt 108900 taaaaccatc acctaacgca cctcatagct ttatctcagc aaatgaagca ttcttagtta 108960 atattgctaa agctaaaaaa ggtgaaatgt cttggaaagt aagtgtttat cctaacgctc 109020 cactaggtgc tttacctcaa ggttgggagc aacaactatc tgacttagag aaattagcac 109080 aaccaacaga agagcaaaac cctaactttg ttaacttctt aatcaataac gttaataaca 109140 cggaattaag tcatgataac tttaagttta accgtgagac aaatgtgtta ggtgaagagc 109200 cttcagcacc taagcaagag cctactcaac aagatattga tagtcagatg ccaagtaata 109260 ttggcgggca acaacaggct cctgtacagt cacagcaaca acaacaacaa caacaacaac 109320 aaggtaatgt tgattggaac aacttagctc aacaacaatc acaacctgac tcaaaccctt 109380 tcaatgactt tgatgtaaat agtattgatg atgtacaagt acctttcaat actcaacctc 109440 aaaatacaca acaagcacct gaaccacaac ctgaaccaca acaaactact caggagcctc 109500 caaaacaaaa acaaacacaa agtattgacg atgtattagg tggtctagac ttagataacc 109560 tataagatat agagtgcctt agagcactct tttatttaag atataattac aatgtaaaaa 109620 ttgtggtatg atagaagata gagatataaa tgcaagtatt aatctaaaac aagcaaaaga 109680 atacacagta ctagtgtaaa agaaaggaag aagtttgcta ttgagttagt acaacttata 109740 aatgattaaa catacggtga gatacatcgg aattaacgct ctcggagtag ttttttagaa 109800 ctgttcttaa taaaggacaa ctacgttgaa cagagaaatt atccttcatt tataagtttt 109860 aataagcaaa tgaggcgtat cgcaagagca aaaaaaggaa aagaagtaga tttaacagat 109920 ttaaatacaa ttgatttagg taaagaatta ggattaacat tattatcaga tacaaacaga 109980 gcagatatta agaatgttat cccgacaatg gttcctcagt atgactatat tttaggtggg 110040 ggtattccgt taggtagatt aacagaggtc tacgggttaa caggttccgg taaatcaaca 110100 tttgcggttc acttatctag aattgcaaca caattaggtg ttattactat ttggattgat 110160 attgaaggaa cagcagataa taatcgtatg gaacaacttg gagtagatgt ttcaaaacta 110220 ttctctatcc aatcaggaga aggtagactt aaaaatacag tagagctatc tgtagaatct 110280 gtaggtaaag aattagagta ctggattgac acctttaatg aaaagatacc tggagtacct 110340 attgtgttta tttgggactc attaggagct acacgaactc agaaagagat tgacggcggt 110400 attgatgaga aacaaatggg acttaaagca tcagctactc aaaaagtaat taatgcagta 110460 acacctaagt taaatgatac aaatacaggt ttaattgtta ttaaccaagc tcgtgacgat 110520 atgaatgcag gtatgtatgg tgaccctatt aagtctacag gtggtagagc atttgaacat 110580 agtgctagtt tacgtattaa ggttcataaa gcgtctcaac taaaacagaa gagtgaatta 110640 actggtaaag atgagtatca cggtcatatt atgcgtattg aaactaagaa gtctaaacta 110700 tctagaccag gacaaaaagc agaagtagac ttactatctg attatatggt aggtaaagac 110760 gatgacccta tcttattgaa cggtattgac ttagaacata ctgtatataa agaagcagtt 110820 gagagaggtt taattactaa aggtgcatgg agaaactatg ttacattgaa tggtgaagaa 110880 attaaactta gagatgctga atgggtacct gtattaaaag ataatagaga gttatattta 110940 gagttattca gtagagtata cggagaacat ttccctaatg gatactcacc attacttaat 111000 aacaaagtaa ttgtaactca actagaagag taccaagcat tagagaaata ttatgaagaa 111060 tgggctacag ataataaaca agaagaacaa gaggaagaac caaaaggaga atctcaagaa 111120 aaggattctg aataatagat ggataattta atagataaaa acatgaacca ggtaaaagaa 111180 tctttggggg atgcaaattc ctcagatgtt cttcctttac cttataaaga tatagcaaag 111240 aaatttgaag aagtaaaaga aaaaggtgaa tcaattatca ttgaagaagg tggattccct 111300 tatacagatt ctacagtgat gtatatagaa catgtaacag atagatgggc gggaggatac 111360 tccttaatta gacatgaagg tgaagaggtt aaagtaccta aaactatcca tttctctgat 111420 atatatgtta aagataaatc acataaagta agaataatct tcgagggggc taatccttat 111480 gaagaaagct aacaatggta atagatatgt aatagatata gacggtattc ctgttgattt 111540 tgaaagagac ttagatagct tacttaatag gtataaaaac cttagatggg cattatacca 111600 taaatatgcg ggtattttat ctaatgactt tgaaagacaa gagttaagag aatacattga 111660 tgagcaattt attaaactag ttaaagagta taatattaga agtaaagtag atttccctgg 111720 atacattaaa gctaaactaa ctctaagagt tcagaatagc tatgttaaga aaaatgaaaa 111780 gtacaaacgt actgaaatta taggtaaaaa agattataca gtagagtcct tgactgagga 111840 tttaaatgag gactttgagg atagtcaaat tatgagttat gtatttgatg atatagagtt 111900 tacagaagtg cagagtgaac tacttaaaga attacttatt aactctgaaa gagaagatga 111960 tgcttttatc gtttctcaag tagcggagaa gtttgatatg aagagaaaag aagtagcaag 112020 tgaattgaca gaattaagag attatgttag atttaaaata aatgcatacc atgagtacta 112080 tgcaaagaaa gaattaaata accatagagt taatactgaa aatcatattt gggaaaacta 112140 gttacggtgc cttccttgtg ttatattatt atcgagaatt caataataaa gcatagggaa 112200 ggctttttct atgtcttata gaatgcttta aaatagatta ctaaaataaa gattggagat 112260 taagcttatg gctaaaaaga atgttaatga tgtattacag caagattctg ttacagtagc 112320 agataaatat ttacaagtta aggttaaccg tgacggttat actcgtacac atgaaggaca 112380 gtatgcgtac aaagtagttt cagagggaga agaattattc ttatatccag tacaaactga 112440 tggtaaaggt acattaaata ttatgaagaa atcacctatt gcttacactg atggagataa 112500 catccatttt gtagtaaaca cagtagtaga cccttataat cactcattta tccgtactga 112560 agatattaaa ggattagata agggtaaaca acttatccaa gctttcttag ctttcgttga 112620 agaccgtttc aaatttggtg tttataacgt atttgttgca aataataaag aagatgtatt 112680 agctatcgta gaccctgcag atactgatgc agacgaagtt aaagatagtt ttaaacatgc 112740 acatgaagat gtaattgcgg atttccctgc tagtcctgcc cgtaaagatg ttaaaggtgt 112800 agattcagga gaaggtcaag gagatacttc agagccttca gcacctgaga atgtaaaagt 112860 tacacctaca gaaaatagcg cagacgtaac agcagaataa tatatagata aaggatggtt 112920 taattggcta aattaaattt atacaaagga acagaattaa ttaacagcgt agaaaaaaca 112980 gaaggtaaaa ctactattac tattgaagga ttaaaggcta atacagatta ccctaaaggt 113040 acttatcaag tatcattctc taatgactca ggagaatcag aaaaggtaga tgtacctcag 113100 ttcaagactg atgctattgg tgttgcttcg gtaacactag acgttgaaag tttagattta 113160 acaatcggag atacacatca gctacaagct acagtagctc caagtaatgc atcgtataaa 113220 gctgtaagtt tcacaagtag tgacgatgct attgcaacgg ttgataacaa aggattagtg 113280 actgctgtct cagcaggtac tgctgacatt actgttgaat caatagcgga cggtagtaaa 113340 acagctaaat gtgctgtaac agttaaggaa cctattcctg aagcacctac agatgtaaca 113400 gtagaccctg gtgaaaatag cgcagatatt actgcatagg aggacaatta agaatggaaa 113460 agacattaaa agtatataag aatggtgaag ttgtaggctc acaagtagct aatggagatg 113520 gagctacaac agtaactatt acaggtttag aagcaggaac aaattaccct gcgggaactt 113580 ttaaagtagc atttgctaat gattcaggtg aatcagaaaa agcagatgta cctgaattca 113640 ctactacagc acctacagaa gaagaaccac ctgcagaacc tgaagcataa taattaagac 113700 caactaaaaa aagttggtct ttttttattg acaatatact tatcttgtgt tacactatat 113760 aagaattaag aaaaggaggg aaagtaatgg atattccaac aatattattt agaaatccat 113820 atgattacac aaaagtaaaa aaattaatgg aaagtaaaga gcagtacatt gtagtaaagt 113880 ttgattcagt ttctgttcat aacttaaatg ttcaaggtat gatgaacgtc attcaagatt 113940 acctacacat ttatggttac agagttaaag aatacgggca agaaaatgct tctaaagatg 114000 atgaaagaga cgttaaaggt tacttatacg aaagagtagg tgactaagtt atgcaagtta 114060 tagtaaatgt taaccatgtt caatcaaata ctattagtgg taccgaagaa ttttttaata 114120 ttatacaagt agatactttt agagaaggat tactgcagat agaagatgaa ccgactgtac 114180 tagcaggatt tatatatgat gataaaatat ttaaagatgc tgtaactcaa gaccctagca 114240 ttctgatgaa cattgaagat aacgatatcc tatatgtatc agatgttggt gtattaccaa 114300 atccatttgt tactgtagaa gaagataaaa agtattattc actattacaa caaattgtag 114360 aactaagtaa tgaagacata cctgaatcta tagtaagaga ttcaaaagat ttaactaggt 114420 attataactt tcaagatttt gaagatgtat tcgatttaaa tagaatttat aaaaaagaag 114480 ttgacacagt aaaagaaaag tgctatacta atggtaatgt atatttatta tatgaagttc 114540 tgccggacta taaactacct ttagcctata ggttacttga agataaggaa catggtattg 114600 ttattatagg ttcacagaca cgttctaata atgatatact gactttttat gttaaaggta 114660 tggatactaa gtcaatagca agtatgttcg gagtagagca ttactctaac tctaacgtat 114720 ttcatacatt cataaatagt cacattaaca ttttaggaaa tcaaataact aagtttataa 114780 aagagaaagg aagcagttat gagtaaatat aaaacagtag aagaagtaca agcagttatt 114840 atcggagtat tatttaagga tgaaggtaaa attgtaacat ccaagtttaa taaaattact 114900 aaagagtttg gtttagatag aataggtaaa gatgacctta aagaaattgt tgaagaaatt 114960 agacaagatg aatatctaaa tgaacttaaa aacaaagcaa ttaaaggtaa agtaacatta 115020 ggagacctta aagatgttgc agacaatcaa gtattcgaag gtaataacta ccatgaagaa 115080 gtatcttctt atgtagtagc taaagaaaaa gaactatctc acttaagaga acaacgtaaa 115140 cataacagac ataccgcata tcctcaaatt atgtttgatg aacttaaaga acatatggtt 115200 aaagaattaa aaggagaaac attagtagaa catcacagaa gtaaagctaa tattaatgat 115260 acagagttaa ttgtattatt atccgacttc cacataggta aattttgtgc ctaggtatat 115320 agaaatatat actaagtatt cttttaattg actgggaggc taaggcttta aagctatgct 115380 aatcagcatc caagttctat ttttttaata tacctgtata tcactaaata ttaagaggtg 115440 atatgaataa tggagaaaca aataaataaa ataaaaggtt ttgaattagt aagcccaaac 115500 cattatattt ctgactcagg tgaagttata tcttacagag gaggaaaaaa gagagtatta 115560 aaacctgctt ttagtaggaa gggctatcta agattatctc tttatcaaag agaattaaaa 115620 aaaggtaaac ctgttactat tcatagatta gtagctttag ctttcatacc taaccctgaa 115680 aataaagaac aagttaacca taaagatggt aataaaacta ataatgatat tagtaacctg 115740 gaatgggtaa caaataaaga aaatatgact cacgcctggg aaaataatct aagggataat 115800 ggttgggcta aaggtaaaaa taactaccaa tgggatggta atcataaaaa ttgtagagaa 115860 gtaatacaaa aagacttaga aggtaacatc ataaatactt ataaatctat agctatagcc 115920 agtagagaaa ctggattagg tgttaacggt ataggtaaaa catgtagaaa agaaactaag 115980 tctaataact ataaagggta tatatgggaa tttaaaaaat agaaaaggtt caacgactat 116040 ccctcggacg aatgtggcta aataaatcgt caataggagt agggctcaag ttaatggagt 116100 gggtgagaat cccttaaatc gaaatggaga acccctaatc taattagggt gaagatatag 116160 tctagtctta taggaaacta taaggagttc ataagagaac cggtaaaaga gttacgtctt 116220 ttattgaatg ttacgtcaat tgtatctgat atgactaatg gtaaatacga ttttgaagtt 116280 cttaaatcaa gactaaatca ctttattgat actacagtta aagagattga ggatagagat 116340 atttctaatg taactgttta ctttgtcggt gacttagtag aacatattaa catgagagat 116400 gttaaccaag catttgaaac agagtttact ttagcagaac aaatctctaa aggtactcga 116460 ttacttattg atattctaaa tgtgctttct gatgtagtta caggtgagct aagatttggt 116520 attattggcg gtaatcatga ccgtatgcaa ggtaacaaga atcagaagat ttacaatgat 116580 aatattgctt atgtagtgtt agattcttta ctactattcc aagagcaggg attattaaat 116640 ggtgtagata ttattgataa tcgtgaagac atttacacta tcagagataa ctttggaggt 116700 aaatctatta tcattaacca tggagacggt ttaaaaggta aaggtaatca tattaataaa 116760 tttatcttag atagtcatat tgatttacta attacaggtc atgtacatca tttctcagta 116820 aaacaagaag actttaacag aatgcatatt gtagcttcat caccaatggg ttataataac 116880 tatgctaaag aattacacct atcaaaaact aaaccatctc aacaactgtt atttgtaaat 116940 aaagagaata aagatattga tattaaaaca gtatttttag attaaggatg attaacaaat 117000 ggatacaata tttattataa gtgtagcatt tattactttt gcaacattta acatagtctt 117060 taggttattt gatttatgga ctacagagaa gaaaatggta agtcaaggac aacccccact 117120 aagtaacttt gagtactatc atgtgatagt accttactta gtaggagtaa ttgttattat 117180 actaagtatt atttttagag attacctata ttctgcacag tcaggatttg gtgttattat 117240 tacaagtttt atttatatgc tagtttatgt tataattggt cttgtagggt catttatact 117300 tacaatattc caagctagaa aagctagaca gtaccacaca caggaggata ataatgaagt 117360 tcaatgatat ttatgagcaa ttgattaaaa atgatacagt acagaacatt catgaatctc 117420 aagatgataa aggaaatatt tataccattc aatttgacaa gggtaacgat aagtatttat 117480 ttaatgtcat caatgatgga ttcctaaaag aaatgacagg cggtatggta gaccatcctg 117540 aaggtcagcc atactcagta agtttaatta ataaagaaac acctagtatg tcagtgaaac 117600 aatatttaac agaagtagaa gatattgtac ctactattag aaaaatggaa aaggatttct 117660 tatagagtca agtctttact tgactctttt tactatatat ggtatattaa tatagaggtg 117720 acttaaaaat ggattttaat tttagtgctt ttgatgatag ttcattagca atgagaatca 117780 gtgagggtgt atactatttc aatgatactc cttactactt tattgagcat gtagaggaag 117840 aactatcaga gtatgttatt gtgtatgata tacatgatag agaggaaaaa gaaaatcctc 117900 agaagaaata tagaatagag tcttatcaac ggacaatacc tggaggaaca cctcttagta 117960 atttaattaa gagtatgatg cctcaacgta aataccctaa gaaggttgta gacgacccta 118020 tatttgtggc taatattatt cctttagggg tagatacaat aacaggtaaa acaggtaaag 118080 ggttctttga aagagataga gatagaacta tttactcaga gaaagaacca actaaggtag 118140 ttcatggtca atatacaggt gtttttatag gtctagcaaa tgttaaatgg aatagaactt 118200 acactccttt agaaagtgtt gtagagtatt gcaagagagt aaaaggagat agattaaatg 118260 tctaatgatg tagttaagtt ctatgaaaaa gatattaaag accttataag aactaaaaaa 118320 cacatgttta aagatgatga aataactagt gatataaatg atatacgtat ctttaatgag 118380 aaagtaattt gccaaggtaa gtgtagaaca gattgcttag tgttagaccg taatggtact 118440 gtcatgggta tagaaataaa gactgagaga gattctactc aaaggctaaa caaccaacta 118500 aagtattata gcttagtatg taagtatgta tatgtaatgt gccacgataa gcatgtacct 118560 aaagtagagc aaatactaaa gagatataaa catactcatg taggtattat gagctatatc 118620 agttttaaag gtaaacctgt tgtaggtaaa tataaagatg ctacaccatc accacacaga 118680 agcccttacc atacaatgaa catattatgg aagactaacc ttatgacaat acttagactg 118740 attagagacc ctcatacgta cagaacaggg tatagttata atgctagtgg tagatatagt 118800 ggaggtgaag gtaacttctc tcaaacaacg cagagtaaaa gaatgaagaa acctgctatt 118860 attaatcaaa taatacacta tgtaggggta gataatacct ataaactctt tacaagaggc 118920 gttatttatg gttataataa taggtgggag gtaatagaag aggatttctt taatactatg 118980 aagaatgggg taagagtaat caatgagcaa agacaaacca aatagacgta aagagataca 119040 acatcaacct gttaactttg cccctacaaa tactttaaca ggagctaata atagtttctt 119100 agctaaaaag ccttcagaac ctaaagatac aacatctgtt attgagtata gaatactttt 119160 tattaaaaga tttgataacg taactaatac tgatgttaag ctacagaaaa aatatgcatt 119220 aaaccttatt agtgaagcac ttgatgttaa agaaacttat ctatctctta agcaaaaagg 119280 aaagaaaaca gaatctatac tccatacaga ccgagtttat tatgttcata gaggtaagaa 119340 acttattggg aagtgtagta tccgagagca aagaactttt agaggtaaac atttaatatt 119400 tatatttaag acaagacata gagttaaagc agaaaggaaa gataaataat gttaaaagga 119460 ttttcagaac atgtagataa acctacaacc attaagacct tatataagac actaacaagc 119520 ggtaaagtag aattactagg ggtatcttat gatagtgatt acttcccttc aggtgttaca 119580 gtacaatcct acattgaaga tatagataat gtagatgaag gtcttcagtt tgttaataaa 119640 gtaaatgtag tggaatcaat gaaacaagct gtagtaggaa tgaataatca attaggttct 119700 tcaggtcttg ggtatgttag aactgaacaa cttaaaaaag aactagaaga aacaggatta 119760 atgacagatt tactttctag aggtactaac ttaacttcta ctaagaaagt agatattgta 119820 agtacattca tagaacctac tgtaacttac caagatatta caatagctaa agatattaaa 119880 ttacgtttat ataaattaga agaggaatca ccattaaatg gttatactca tattgtatat 119940 cttcttacta cagaaaaatt atatgatggt caaacactat ttggtatgtt atctaagaaa 120000 gataagttat ctaaaggtga tacagaaaag ctactagctt tcttcagaaa taatagttta 120060 ataagtaaaa gtgtattccg tgttaagtta ttaagtagag actatcactt taatttgtat 120120 aatacacatg agacaggtat attcttttta gaagatacag atattattac tattgcttgt 120180 ggtcagtcat atgttaaagt taacactaaa gacattaagt ctagtcatgt taaaattgaa 120240 aatgatacta agaaattaac tgagataata attaacttaa aaggtgaaga tacattaacg 120300 attttattat aaatatgtag taattaggta taaatatacg ttatataaga agttttcata 120360 atgtttttaa tacagaaact agttaggttt tttctactta ctctagtttc tgtgaaatta 120420 tatttatgaa aagttaaaat atcttttagg taaaggcttt gtaattagtt aaaaaatata 120480 ctaaaatttt atacaaagta gttaataaaa ttatattaca tttatatatt atgaaataat 120540 aacagaaatt gtgatatatt atatagtgta accttgaaac agttgatgtg gtaagggttt 120600 gtttatgttc attaacctgg tttcagaaaa ccagttacca taaataaatg acagttaagg 120660 agagctatat aatggctaga aaaaagaatt taagaaataa aaacagtaat ataaaagttg 120720 ttcccgataa agaaaaagaa agtatattat ctaagttata tcacaataaa ttactacgct 120780 caaaggtaga taatgcatta gatgaggata tgagttatga tgatattata gaactctgta 120840 aagaatatga tttagaattg tctaaatcag ctattacaag atacaaaagt aaaagaaaag 120900 aagctattga aaatggttgg gatttaggag aattaattga taaacgtaaa aaaacaagtg 120960 taaaagatat taaggaaaaa gaaactccta tattagaaga ggagcaactt tctccatttg 121020 agcaatcaaa acatcataca caaacaattt atgatgatat acaagtacta gatatgatta 121080 tatctaaagg tgcaaaagga ttagaatttg tggaaacttt agaccctgct ttaatgatac 121140 gtgcaatgga aacaaaagat aaaatcacag gcaatcagtt aaaaggtatg tcatttattg 121200 ggcttagaga gctacaatta aaacagacag ctcaagacac agctatgagt gaggtattat 121260 tggaatttat acctgaagag aaacatgaag aagtattaca acgattagaa gaactacaaa 121320 atgaattcta caaaaatcta gatttagatg aagaaagtag aaaattaaaa gaagctcttg 121380 acagagtagg ctatacaatt tagatagtga ggttagagta atggcagaag agattagttt 121440 aaatccaata caagatgcta agccaattga agatatagta gatatcatga catatttaaa 121500 agacggaaaa gtgctgagag ttaaacaaga caaccaagga gatatcctta tcagaatgag 121560 cccggataga cataagttta ctgaagtatc tagggattta gataaagagt ctaccttcta 121620 taaaagatat tgggtattat ggaatatatc tattaactct cttataacat ttgatgttta 121680 cctagatgaa gaatattcag aaacaactaa ggttaagtat cctaaagata cgattgtaga 121740 atatacaaga gaagaccaag aaaaagatgt tgctatgatt aaagaaatac ttacagataa 121800 caatggtaat tatttctatg cacttacagg agaaacaatg ctctttgatg aaaataaatt 121860 aaataaaatt aaagattaag gttgacagtt cttaaagtat atgatatagt atatgtatac 121920 taaaaataaa ggagctaaca attatgttta tttcattaaa tcaagaagag aaagcattat 121980 taactaaaga ggaaagcaag tacacaccgt tagaaacatc aagagagttt aacacaccta 122040 aggaagaatt cattgtaaca agttataacg aaggtaaacc tttagattat attgcaaaag 122100 aagctaaagt aagtatggga ttaatttaca cagtattaaa ctactataaa gtaggtaaac 122160 gtaacaagaa atcacctgta gaagaaaaaa ttgcacacat cttaaaggat aaagacttag 122220 ttaaagagat tattaaggat taccagtata tgaatttaca ggacatttac agtaagtata 122280 atcttcataa gaatggttta tattacatct tagatttata ccatgtagaa agaaaatctg 122340 aacttaagga caaagcgtta gaagaagata ctattgtcgt tgagtaagta aagaggttat 122400 aatatgagaa ataaaaaatc atttcaagaa cagttaaatg acatgcgtaa taaagagaaa 122460 tgggtatctg aagaggagtt cactgaagaa gtgactcctt ctgaggaacc tgaagtagaa 122520 gaagaaaaac tatacacttt agatgagcta aaagaaaact tattagatgc tcaaggatta 122580 aaagatgttg tagataattt tcctgcatct aaaccactat atgaggctaa taagctttat 122640 atctgcacaa taccaaaagg ttatcgttct aaagaagtac aaccaggtca atacattggt 122700 atcagtacag gattattatc agagtcagaa gaatttgacc atttaagagg tcaaatgcct 122760 agaaatcttt atgaaacttc tcatgtttta aaacctttag tccgtattaa taatacaagt 122820 atcgaatatc aacagcatga gttacttgaa gatattaaag aagacaagaa tgtatatgat 122880 gttgaattag aagacttgag attagtaaca ggagaagaaa tttctcattt agagattgtt 122940 gatagtaagt tttttgaaag acgtattaat gaagtccttg acttttatca tgaattaacg 123000 gattccgata atttaattga gtattatagc aaattacgag agttagttgg aaatgataga 123060 atgatttact gctcactcct agataaacgt gttaaaatta tagaatagta actggtctcc 123120 tcttatatta gaactgtaag aggagacatt tttgtataga ggtgttagtt atgtcaaaaa 123180 aagcaagtat attttatgta ctagtggtta ttgttttggc tttttctatc tcatcttatt 123240 atatatcgtc tttcatgtat cacgacaaag caaaaagtca agttgctacc caattaacaa 123300 atacaggaga aattaaaggt gaagagaacg ttgagtttgt cggtgactat acattgaaag 123360 aggttaagaa taataaagct tattttatgg aaacattacc tacttacctt ccaggtagaa 123420 caggggataa cagcatagat atgaggtact acaaaacaag tagatttaaa gagggagtaa 123480 gttttaagct tattagagta tatactgaag atggagacga taacccagtt cataagtata 123540 ggtttgaggc agtaccaacc gaaaagtaat aaggaggtgc cttaaatgac agtacttatt 123600 gttgtcatct ttattgctat catttattac ttatggaaca gtgattgagt caagttaatt 123660 cttgactctc tttttgtttt atggtatatt aatatatagg aaggagagat tagatatgga 123720 aatggtagat ttagaaagat ttgatgcatt tgtaagacta atttcagatg atgagctttc 123780 ggaggaaaga atactagagt taagcgtaga tttactaaat ccgatactag aaggaggtac 123840 agcttacaaa gctaaaaaac gtattcgaag taaatttggt aagttagaag caaaaaactt 123900 taaaagaaat tataagttct tacttaagtc gatagctcaa atagaccaaa ggagatagaa 123960 caatgacaga aagggaaaaa ttagttaaag atattgatga ggctaacaga gatattcaaa 124020 ttaggctaaa agaagtagac gattataagg atattatacg ctctaaggga acacgtaatt 124080 atgtatctac aaaagtatta gattcagtta tggtaggact aattataagt ttctttattc 124140 ttataatcct acgtgttatt gagtattttg taacaggtaa tgctgtttac tcacctttag 124200 cacctgcagt tattattatg tttgttttag cactaggaac ttggaaagta agtaagatga 124260 ataaaatagt atcctacaga ggaagtataa agatgtattg ggaactaagt aatgctgaac 124320 agaaccaggc tgagatattt aagtatccgg atgatgaagt agatatagta gcaaagcata 124380 agttgagaca aattactttc agtgagataa atatacttca ctttaaatat atgaagtata 124440 ataaagcagt agagaaccac actaaactat ctaaagaact ttttaaaaaa gataaggaaa 124500 ctgttgacaa gaacaaataa gtgtagtata gtattactaa aggaggagag atattatggt 124560 tatacctagt attaaagcac aaaacaaatt caagaatgag ttagagtatt ataagcaagg 124620 tcacattagt gaaagtaaaa tgttagaatt agcttttgat tacatccaag aattagaaca 124680 aaataatgaa tacgttacta atttactaga agaggagaga tatggtgagt aaatttatcg 124740 gagtgtactt atttaattta ttagtagtaa cattaattta tacagtaggg tttttattct 124800 tttacggagt agctagttta gttattctta taactcatgc tacgattgac ccgtttgtat 124860 tagctacttt cttaggaata ggattcttga ttatcagaac agcacataga attatgatac 124920 gagtagtaaa tgacgcagta gcccaagcca ttaaggataa agaaaatgaa taaaggggaa 124980 tttattatgg ataaatcatt accaaagttt agtgtatatg aagttattgt aaagactgta 125040 attatgacac ctacagaagg aagttctaac cgagaatcat tttacttttc aacccgacag 125100 ttagcagaaa gatttgttaa ggaaaatcaa gtagaaacaa aggatggaaa acgtgtatct 125160 ttttctatta aagaacgtaa cgtaaatcaa ccaggctaac attaatttgt tagctttttt 125220 tattgacaaa tcgttttata tagtgtatag taatattata cagaaaagga ggaattatta 125280 tgaaagtttc agaagaagta aaacaaagtt acttagagaa taaatctaat actaaaatgg 125340 ataagataag ttggtctgag ttaaggtcta gtcctgcagg tagaacatta ggagaattaa 125400 tataccttag tgtagtcgta ataaataata tcatagctat aggattaaca ttaactctag 125460 gagacattat caaagactca attgatagta ctttaataaa aataataagt atattactta 125520 ttattatcgt tgtatacggt atactatcgg ctttaatacc tatactcata tttaaatctg 125580 tatttcctgg ttgggaatat actgaatgga ataattctta ttatttgaga ttacctggag 125640 aaaaagatta taagtactat agctactggt atttaaattt attaggtgtt actgagtttt 125700 atcggacaaa tgatgaaggt aaagaaatta aagaaactag tttaagttgg gttttttata 125760 ctaaggttga tagacctgag gatattaacc attggaaaaa tcaattaata actaacagac 125820 ccttaacaat ttccgagtac aaaaaactaa agaaactaga taaagaaagt gaaattagga 125880 agcaagaaga tttagaagag tatcaaagat acaataattt ataggaggtg agaaaccaat 125940 gataagttca tttgatagtg tattacttgt agtatacatt attatagctt ttgcagtagc 126000 tatggggata ctttatttag tatttaaagg tatgtctatt ctactagata aagtgatgat 126060 gttattatta agtaaaacta ctttagatgt agaagtctgc tctatgatag tagcagtcat 126120 cagtacaatt gtgtttggaa ttatcatact tttagtatgg ttagtagtaa acaatatttt 126180 attgtaagga gttttactat ggattttaat gactttataa acagtgagtc agatagagta 126240 ggtaaaccta aacaaaaaaa gaaggtagaa aaacaactac cttcttctac tcctatcgaa 126300 gaaaaggaac aaatgttgaa aagaataaga gagaaatcat tatatattga tttaaggaga 126360 aaaagaaatg actagagaat atctatataa tactggtgat atagttaatg atagtttacg 126420 tataatggaa aaatcaagaa atattaaaag tggtaaaaaa tcatatatag tgagtagtat 126480 aaaataccct aaagcccctc attatagtat attagaagag agtatagtta atgggcaaag 126540 agatgcttac ttaagtggta ggagaatatt tgagggtaac tccttataca gcgtagaatg 126600 gattagaccc tatttagtag atattgatgg ggctaaacat atagctccaa atagcactaa 126660 gaaaatagaa tttaaatgcc ctaattgtaa tagagttaaa gaagctaaac caaacaatat 126720 tataaatcaa ggtttttcat gtaacttttg tagtagtaat atcagttatc ctgagttatt 126780 tatgatggca tatttagaag taaagggtat taactatgaa tatcagaaag tatttaaaga 126840 tttaccaaat agaagatttg atttctactt acctgaatct aatactatta tcgaaacaca 126900 cggtattcaa cactatgata aaaaatcaac atggttcagc caagcaaaaa tacaggatga 126960 agaaaaaaaa ttatggtgtg gtaagaataa tattttatta gtagaaattg attgtaggaa 127020 gtcaagttac atgtatatta aaaaatctat taataattct accctgccta acataaggaa 127080 tacagaagat aaagatattc aaagttatgt agagtattta aactataata acttaaaaga 127140 aatagtgggg ttatatgaag aaacaggtag tatggaaaaa gtaggtaaaa aactagggat 127200 aagtaaaaca gcagtaagaa atacacttca acgaatcagt tataaaaaag aaagagggtt 127260 tgaagattct ctagttattg agttatataa aaagtactat tctatgaatg aggtagctaa 127320 agaaacaggt atcagtacag ctacagtgtc aagaatttta gaaaacgaag gtattaaaag 127380 aataggtaca aaaaagaaca caaaaaaagt attatgtgtt acaacaaata cagtttattc 127440 aagtacctct gaagctagta aagaaactgg gataaatatt ggtagtatat ctaaagcttg 127500 taataataaa attaaatacg caggtaaaat aaacgaacag cctgtgtatt ggaagtatat 127560 aaattaattt aaaaaacttt acattaaagg cttgacagat gaatcatttt aatgtatagt 127620 aagagtataa ataaaaaaaa gaaaagagga atgattatta tgttattagg aattttatgg 127680 tttatatggg gatttgtatc ttactttgtg gttatgcttg gtgttgagtt ttataaagat 127740 agatggatgc caggagttat tggggcggga gcagtgttac tatttatgtt ttgggttatg 127800 aaatctatcc ataacgctat gacagtagta tacttatact aaaggaggga tactagatga 127860 atatattagt tatccattat gaagaaacaa ataaacgagt tctaaaagaa acaataaaaa 127920 caatacaaaa tcatttaaat gatgaacatg atttggttaa aatgacagca acaagactta 127980 atagaaaagc catagaagaa gagtttaatg attacaatat agttattgca gagaatgacc 128040 ctgatatttt ttatggctat gcagatgcag tagaagaagc ggattttatt atagatatac 128100 caatttcata tttagatata catgcaggtg tagagtggga tgtcgataat cctgtagata 128160 tgttagatag aaaccctgat tttatagagg ctatgggtaa attaaatgag gacttaatgt 128220 tataaggagg aaataaaatg ttaaatgaaa agctaaaaaa cttagaagat tcaaaagtat 128280 atttgattaa tggtattgca agcctactaa attcaagtac aggtaacttg agtaaggtat 128340 tctttgatga aggtgatatt aaaattgtaa gtggtgatat aaaagcagta gaagttattg 128400 ataacttagt tcacccgcac tcaggacgtt tacctattaa aacaacagaa cgtattgctc 128460 ttggtagatt aacagattct ttacagtttg ttatttcaga aatagaagtt actaaggata 128520 aaattataga tgaagaaaat gaatcttaca ttgattttat gatggaagat tgggattggg 128580 attaacgcct atggacttaa tgacagtagc ttctattgcc tttatagctg tcgttattat 128640 tgatttactc aatgatgaca tgagctatat attggcaggt attgcaatac taataaacat 128700 ttgggcaggt ttttatgaat ggttcttttt actacaagca ggtatgctac ttttcttact 128760 cttagctaga aagggtgaag atgctaagga atctatagta tactcaggtg cttcagtact 128820 atgcgtattg ggtatgatag taaatctttt tgtattttct taaaaataag tattgacact 128880 tctaaacttt tgtattatac tataagtata ccaagtacag gagatgatta atatgagtaa 128940 agaaacaatc agaagacaat tttcaaatgc aattgagatt atggcaacaa ctaaggaatg 129000 gtggaatttc cctaaaagtt ttaatacaaa taaagagttt aaaattaaat cttttaaaaa 129060 tgacacacta gtatttgaag ttagagaagg taatagaaat ttaggaagct ttgtagtttt 129120 cacatgtatt gactttgatt atgataaact tgaaggaact tcaacacaat acatgattaa 129180 ttactttgct aagaaggtag ttcgtgacat gttttcattt tacagattac aatcaaaaat 129240 gtaaaaaaac taaagggtgg tatatatgag catatataat tatcaaatag gggagatagt 129300 aaataacagc aatgaatttt ataaaaaata aagtatttta actaggaggt gaaattatga 129360 gagacgaatt aaagcaattc aatagaagaa aagtgaatgt ttgtggttat ttagatgatg 129420 ttaggtactc aaagcgtaga aggcataaag gtaatcagca tggatgtgta aaaataacag 129480 ttactgatgt aacaattaat ggtatagcta ttgaccatgt taatattgaa gtaggtatat 129540 aattttatga aaaacttaaa gagttacaag gtaaaagaat tcaatttgta ggcactgttt 129600 acaagtatgt taaacatgct agagggtata aaggtaaaat taaaggattt tataaagagg 129660 attatagtgt aactttagat aagaagttac aaaaggagga aaaataatgg taaaaattaa 129720 aactaagaaa aagctaaacc ttcctcaact aatagaatat gcatgggata acggtattac 129780 aaacaaagaa tatatttgtg atggctttga aattaaatca gtcgttttta atttatcggg 129840 ttgggcagaa tttagtgatg aattttcata taatccacac gacactttca cagttgaagt 129900 cgaggaagaa ttaacggaag atacagaaat acctaaaatg ttggtcatag gtaggtttga 129960 tggatacgag gaagtgtaca atcaaaaact aagctctttt aatcaacatt tactaagtgc 130020 ttacttaatt cacgatgatg gatatatgga gttaatatat gacgaagtta aagggttggt 130080 ggagtagatg tctgaatggt atgctttatg ttattatgat aaagtaggta aaaagaagaa 130140 acctaagcaa attagagcac atagagatat ttcagtatta gaggaactaa aagagagact 130200 agaagaaaga aaccctgaca cagagtacgc tataaaaaca acaaaagagt ttgataaaat 130260 tagagagaag ctgtaattat atggtaaaat attattataa caaatatatc taactgttgt 130320 aatgggaaaa taaaaacagc aggtaaaatg gaatgggagt atatttaatg ataaggagag 130380 ataggaatgc tgacaccgga acaatggact acgttaaaag agcaacaaaa aaaactaagt 130440 aaaaagaaga aataactgtt gacaaaggag tgtacatagg ttatacttaa gttaataaat 130500 aaagaggggg tatgacctat gttattcgta atttttattc tagcagtatt atttgtatta 130560 ggttttatta acggttataa ttcagaggat taaaaaaaag gagaggttat aatgaagtta 130620 gaggataaag tgttagatag aattgattcc cttgggggta aattagacaa tattagtcag 130680 cacgcatggg aagccctagt aaagtatcaa gttatgtatg gtattataga ccttatcgta 130740 ggtattgtag ttatagcatt aactatactt ctatggaaga tatttattaa ccaacataaa 130800 aaggtaagaa gtgaatatga tgaacatagt ttactattta aatgtcgtgg ggatttaaca 130860 ggtataggtt ttacctatat aatagctacc tcattcatat cactatttgc acttatttat 130920 ttagtatacg gaatacctat ggatattcta aaaatactaa accctgaagt atttgcagta 130980 aaagatttaa tcgaacaagc taaaggagga aattaatatg aaacaaagag attttgaatt 131040 tgaagaggat tttgttctag cttatgaatg tgtggattgt aaacatttcg aagattgggg 131100 ttatgatgaa gagcctgaag aatgtagtga gtgtgggagt agtgatttaa ttaataatac 131160 aagtcatgaa aacactgagt gtgacatgtg taaagggtac attgatatgt ggcaagatgg 131220 atatagatac atgggagata ataaagaata tattgaaaaa gaagattcag gtttaatttg 131280 tgaagattgt tatgagaaat tagatattta ataaggagga atttatatgc cagtaacggt 131340 acctcatgtt cctgttgtaa gtaatccaac aactactagc cctactacca ctacaagtgg 131400 taatacagaa actagagaag aaacgatagc acacaattgg gaacctgact taatatcaga 131460 tactgaagct atgtacatta ctatagctgt tgttttaatg gctattatag catgtattgg 131520 cttatggatt tatgctaaaa aatttttaaa taaataggag gaaaagaaga aaatgaataa 131580 cagacaaaag aaaattttaa cattaacggt aaataacttt ttaattctag ggttagacat 131640 tatagcttta attaggtata aaaaaggtaa aactaaacaa gagaattaca atgtaggaca 131700 gattactagg gtaatatcta caacagctaa ctcattaggt attctttatt tagaagaaca 131760 agaacgtaaa gagaaggaat ctgttaaagt agatacctct aaaagcggtg ctttgggagg 131820 atttaaaaat aaataggagg tttaataaaa aatgagtatt gaattaaaaa aatgggaaga 131880 aattattaat aaacaagaag aaattggtgg gtgccctaaa aaggctaagt tatcctttac 131940 aggtaataaa gactgccaat cattcaaaga tagccttact gatgaagaag gaattatatt 132000 ctacgtacaa aatgaaaaac tagaagtagt tagttcaatt gttgttttag ctaatggtga 132060 gactgttgtt acaactgaca gtaaagtaac tcatgatatt atacctgatg attttgaaac 132120 ttcggaagag tctgttgtgg agtttttaga taatttatat atgaaagcta cagaagagta 132180 ttataactgg ttacaactac aattagttgg tactcagcag gaagacaaat taccaggagt 132240 cattgcagaa ttatcaagag gtcttagagt aggtagtttt actatcaatg accgaaatat 132300 actcattcaa agaagaaaag taagtataca tttacctgag ggatacttaa ttgttattga 132360 atactctaag gatgaaggta gacatattat agatactaaa ttgcaagatt ctgaaggtac 132420 gcttattaac cgtattatta aaacagatat tacgtatgat ggtttaggtc atttaactaa 132480 taccttagag agtattgtag aaccaatttc attataaaaa aagtttaaga aacctattga 132540 cagtaggttt cttttattat atactgagag tataagaaat aaggaggtta acttatgaaa 132600 gggattatta tattttataa agaagaaaat aaacacatcc taaaggagct tttagaattc 132660 attaacacaa cagcaaaagg gctatcttat actacagaag gtacactagt cgataacgat 132720 atcgttttac ttgaagataa tagcatgagt gaatataacc taagacagtt tagtgagatg 132780 aatagtagtt tagttatagg attactaagt aaatcatata atgatgttca ctactatgaa 132840 aaaggggatg cctatggtat aagcatctta gatgattatt tagaggagat gagtcaataa 132900 tgttagcaat atttgcatta atttttggtt tactatttat tttatcttta ttaggtattt 132960 ttatttattc tatagtttta cgaaagaaaa aacaattaat agaggaacga gaatcttttg 133020 gtattcagga accagggaga caggtaggtc atacaggtta tgttgaaagt aaatatgctt 133080 taattcataa agaatcaaat aaaataataa taagtgcaag taaaagtaca gttatagata 133140 cattacaaaa aatgtataat ttagaattaa catctgtaaa cgtttctgat gtgaaaggtt 133200 taactccttt cggaggtcat atagagaaca tgatattact ttcatacaaa ttagatagag 133260 aagggctcta taaattaatt gagcttaata aggaggaata aagatgaata tactagcatg 133320 taccaagaag aaattgaaaa taagtgttga caactgtaag atagtatgat atagttatga 133380 tatagtatag aaaaggagga agtagaaatg gtaagatacg aaccaaatct taacggagaa 133440 aattatattg caacaccatc acaagcttta agagaggcac tatccgaact aatatctgca 133500 gaaaaggatt ttgcagaata tcaaactaaa ggtgaggaac aatatgaatc acagttacaa 133560 ctaagacact tcgattcaat gatttctcag tatgaagagg ctattcgagt actagaggat 133620 aagtattcac ctcagatttt tattccaaaa gataataagg aggaaaagta attatgaaag 133680 caaagtcaat agaacggttt tttcaagaca aggtattaca aatagagggg tataaagtac 133740 ggttttcaca agctagttcg acatatattt tagacataga tatgatagat gaatcagtat 133800 tgtttttaga tactgtagtt ttcaccttat caggtaagta cttattagat acacagatta 133860 cgattagtaa acctgaaaca ctaagcccta ctgaattata cacagagatt agtaatactt 133920 tacaagatat tgtaggagac caaactaaaa cagatataga gttatcaaga tactttaagg 133980 aggtaaaata aatgaaatca gatgctatta taaattcatt attaaatatg gaatatatag 134040 atatacaaaa acacaatata aaagtaactc ttgagaaggg tagatataag ggcgtagggc 134100 atttcataga atttgaaacc tcaatacaat acagggggaa ttataaatta cagcctgcaa 134160 taactatatc ttacgaaaat gaagagccta aggaaatcct tactcaaatt agagataaag 134220 tattgaaaat tgtagaagag cagataaaga cagatgatgt atttattgaa gcaattgagg 134280 agattaataa ggagacagct cttagaaaac tgaagcccta tattaatgaa gaatactact 134340 cagtgtttaa atcatctatt gataagggag tacctgtagt tttaccttct gaacttttag 134400 atagatgcac aggaaaaaca tcaacaatgg cttatttagc tgtagaatat gatttacctc 134460 tcgtagtatc aaacacagtg aaggttagaa tgttattgaa tgactatccg aatattaaag 134520 tcacatcaaa aaaacgagaa ggctataacg attcaatagt gttagttgat gaacctgacc 134580 ctaagatact aaatctttac ttagatgcac ctgaatgtga tattattggt attactaaaa 134640 attaaataaa tttataaata cctgttgaca gcaggtattt attatagtat actttagata 134700 taaagaaaaa ggagaggtta acatgaatta taaagaggta ctagaaacta ttaaaaagag 134760 caaaccatgt aaggttagat ttactggaag tattgtagca attgtaaatg aggaatttaa 134820 tgcagacact ggtaaaggtg tattacagat tgatgtatca gatatcaata gagacgatta 134880 cattaagcta caacagtatt gtttagaaag agatgattat actgtagcag gtgctatttt 134940 attttaagga ggtagtacta tgacaagtat tataatttta attgtaggtt taatattatt 135000 tttagctagt ggatacaaat tagttttagg taactattat gatactgcag atttaaaaat 135060 gttatttaca atatttggta ttggtgttat actattactt gtaggattta tattatagag 135120 agtatattaa atagttgaca ttaaataagt aatgtactaa gattaatata taatcaacta 135180 ggaggagata ttatggaaga aaaaatcaaa gatgtgttat catttatcct tttcaatata 135240 tttataacgg tattaggata tataattttt acaatttaaa acatagattt tattacagta 135300 attataaaag aaaggtagat aaacatggga ttagacttta ttatagaagg tgtaacgtta 135360 agtaaaagaa aagtagaaca agaaggttta caacatttca taaatgacaa tagatattat 135420 agttatatag ataaaaacca tgagttaaac tttgaagcat ctttcagaaa acctgatgaa 135480 tttatgggta tcttagtgca aaacgcaacc aagtatttcg atgaaaatta cgaatatgac 135540 gaaggtaaat atgttttaac acagaatcag ttagtaaaat tgattgacaa tagctttaat 135600 gaagaaatgt ttaaatatac tgacgatgaa gaaaattatt atcactttat gtcaatggtg 135660 tgtgatgtaa gaaaatataa tagtaaattt tatgattttt atttgattat gagaataagt 135720 gtttgatgaa ttaatagaga ttttataagg aggaggaatt attatgaaca ctagacaaat 135780 tattaaagag gttaaacaag gcacagcaga gtacaaagtg gatgagattt cggtgacaga 135840 cctacaaaat gctaaatact atttagaaga tgaaaagtta tctatagtag gagaatttgg 135900 aatctatgag ggtttattac atgagcaaat tactcaaggt attcaatggt attatgatac 135960 agaatgtata ggttatttgg acttagcaag aaatatatta tttgttttaa tagagcaata 136020 cattaatgaa gggtatttaa aataaccgtt ttataggagg aggagttata atgtatagat 136080 atttattatt tagttatgaa ggttactacc ctaatggagg cataggagat ttaaaaatta 136140 gttttaatac tatcgaagaa ctagaatatg ggtattccgg tgaacctttc ggattatgtg 136200 aatacattga tgtatttgac actaagacag gtagaactgt aaacaaaagt gattacttcc 136260 ctgaagtagt tgaagaagta aaagagtatt taaaaaataa ttaaataaaa aactttaacc 136320 ctagctattg acttagctgg ggttttgtta tatacttata tcaagaagtt aaaacaaata 136380 caaattttat tggaggtttt aatatgatag taacatatat ttttctagtt tgtttatatt 136440 ttgttcctgt atcgtgttta gtttatttat tggtaaatat aatacgagat gatttaaaat 136500 aaccatttta aactgttgac aacgaataag aagtatagta taatagtaat ataaacaaat 136560 aggaggaatt atatatgaga aacgcagaag aaattagaga agagcttgac gatatttaca 136620 gagtattaag acgcagtgag gatatttcag acatgtttaa actagacaaa aagtataaaa 136680 gagaactaga aaataaacaa ggcagattac aaaaagaaat aaatgaaatc aatcgtataa 136740 atggtactga atattaagga ggaggagtta ttatgagtaa catatttgtt agagaagaat 136800 ttattgaccg tttagaacaa gaaggattgg aagtagttga ggaagatggg tattatacag 136860 tagaagatgt agaaggtcat gttattacta tagagtttaa agatgataca gtattagtca 136920 tggataatga agtaacagag acagcctaca acgttaacca aatctattta gctttctatg 136980 cagtattaga tgcgttagat tatgaatttg atgaataata aaagaatcat tttataggag 137040 gattggtaat tatggcatat gtaacacata ggcagattga ttacatagtc tacttgcaca 137100 agatacttgc agaatttggt tatgtagact ttgagtttaa aacctattca gaatatagta 137160 aactaagcac taaacaagca ggtgtatata ttaggaaact agaaaatgaa atgactccta 137220 atgtatatga tgctatggaa gagaaagcgt gtttagaaga agtgtatggt ataggacaag 137280 aataaaagga atcattttat aggaggaaat tatgataaac ataaaacatg attatacaat 137340 aagaactgtt gataatagaa aatactcata tggaaatagt tacaagtcgt taggttctgt 137400 atacagagat gttatgggta atgattatat agaagtaact aaatggggta aagataaaaa 137460 ggttattatt gatactagac atattgtatc tattgaacga tggtaaataa caagaatgaa 137520 tagaaagtat gttaaggtta gtatataaaa tataaggggg aagtaaatat gtacaaagaa 137580 gtaatagagt taattaaaga aagaattagt tattataatc ataaggaggt aagtttctca 137640 ttattttata ctcaccatga tgactacgca ttaaacataa gaagtaatat acatgaagaa 137700 gaatcagtta tatactcaat agatttatgt attatggatg tagcatcctt ccatttagct 137760 attagaaaag acagagaaga aaaaggtaag attagattag taacggataa gtataatgat 137820 tgtaagtaag gtagttatgg ttattactta atagatagga atacacttga tacttacata 137880 gtggataggg aagaacttat agattatacc actcagtata ttatagaagg gaataaggtt 137940 aatattaact tagtatagta tataaggtaa gtataagaga taatagaaga agagaaaatg 138000 aggaggaatt actatgaaat caataagaga agaaatgaaa gatagaattg ataaacttac 138060 tatagaagag ctaaacgaga tttatgagag tgtagagtta ctacaagata atgattattg 138120 gaataaagaa ttagatgaaa ccgaagagga aattgcgtta attaaggaga agtacaaaga 138180 tagaggtcta aaaggcttag aaattgtaaa agaagaacaa gctatttctt atgctcaaga 138240 ttctattaat aacctctatg attaaataga aaaattaatt tagaaaaaaa gtgttgacaa 138300 ataattaagt gtgtgataca ctaaatatat aacaaataaa aggagatttt aattatgaaa 138360 acaattttaa aagtagttat cggtattatt ggggcattta ttattatggg aatgttattt 138420 gcaggatgta cagcgtttgt atttaacgaa gcagataagg aaattactaa acaagataag 138480 aaagataaag aagaggctaa gaaagaatac cctgtaggaa caacgaaaac ctatgaagat 138540 gtagatgtaa cagtagacag tgtagagcaa gtaggagctc ctgaaatggc ttcacaagaa 138600 ggtacatttt ataaagtagc atttacgatt aaaaataata gtgatgaaga tgcaatgttc 138660 tcaacaagtg attttaaaat gcaatcagaa ggaaaacaat ttgatgaatc tatggatttc 138720 ccggatgctt tcgatttaga tagcattaac ccaggtaacg aagtgacagg aaatgcctac 138780 tttgttgaca cgaaaggtac aacagaaaaa ccacaagtac aattgtcatt ctcaccattt 138840 atgattaata cacataaagt taattttaaa taaaattaaa aaactttaac tctatctatt 138900 gacttaggta gagttttact atataataag agtatactaa ataaggagat gatttgtaat 138960 gtcactaaaa ctaagtaaag aatttaaaaa attattaagt agaaaaaaag caagtaactg 139020 tgagagaatt gtaggagcat tattagaatt gaataatgta gaatttcaaa tagaaagaac 139080 ttttaatgat ttacctagga agaggtttga tttttatcta cctaaaacaa atactttaat 139140 tgaggtacat ggggagcaac attataaaca atcaagtatt tttggtagtt tagaggatat 139200 taaagaaagt gatagaataa aaaaagaata cgctaaagag aatggtatta cctatataga 139260 gatacctgct aaacgttcag agattcctac tataagaaac agtataaaac agacaaaatt 139320 aaattattta ctagaaaaca tagatgaaca tacatggaaa gattattcta ttcttaggga 139380 aggtaaaact aagttacctt ctgtagaagt actagatatt attaataatc taaggaatga 139440 taatataact gaggatactt attcagagga ggaggaagaa gcattatata tagataggtt 139500 aaataaagtt agtataccgg gtgaagtaaa gtgccttact actaaaaagt tatttactga 139560 tatacaagat gcttgtaact attataatat agagtattca gaactcaaag aaggtgctac 139620 ctattataaa catgaaggca agatgattat actgagtaaa gtgtaaggaa gaaaccaacc 139680 aataagaata accaagaaag aaaccaataa gaataaccta atcaagtaaa tacctaggag 139740 cctgggaaaa cttttacctc tcccattcgt tcaatcattc actaccgact ttcctaaata 139800 cttattatat agttatacta ttcatttatt atacaatagc taaactatag tattccgacc 139860 ttaatctatg ctgaagcggt agtaatctat tgttattata taataaactt atctaatggt 139920 acactaatct ataataaaag aaagtattga caatagtaac cgcttctagt agaatagtat 139980 atatataagg agggatttca tgatatcagg aatagggttt ttattaatgg ctattagtat 140040 ggctgtatca gtacttgtag atgatatgaa gcggagtagt ttattaactg tattaggggt 140100 tcatttagta gggcttgtac tactagccat aggtatatta tgttattaat atgcattaat 140160 atgtatactt atacaatatt attaattatt ctatttttaa gttttttacc cctagtaaaa 140220 gtggtactac cttaaaaata cactgtgaat cctattaatg ggttgacttt taattaaaaa 140280 gtataaggtt ttccctaggg taaagtttta atgtacctaa atatttaagt agaagcgggt 140340 aaatctagct tactaataat gtataaaata gtgtatatcc gcttcaatta caattaattg 140400 ttgacaagta tgaagcggta tgctatactt agtatataat caattaggag gagttaatag 140460 tgaaattaca tttagataat aatattgtag aaggtacacc tgaggagtta gtaaagtatc 140520 aggagctatt aaaagagaaa ggtctaacaa aagattctga taagtctttg tctcactttg 140580 agcataagca tcaacgagtt gaacgagaag ctcgagatac ctttcaaggc ttacttggtt 140640 cactgaagct agataagtca tctataggtg caacagaaag ctctacagag gaagcggaga 140700 ccgcttctac agatattcaa gtaggagata gagtaagagt attaaatagt aaacatggtg 140760 ctgaaggaga ggctactgta actgctgtat tagaagatgg ttacgtagag ttagcaggta 140820 caaataaaaa tggaatgtat ttaactgact gggctaacca tgtatcaaac ttagagaaga 140880 tagaagatgc tcctatgggc tatacttttt ggtatataga cgacagaggt gtacttaacc 140940 accttaatgt actaaaagca acattagaag gtcattttga agattcaaca ggaactatat 141000 atacttatca ggctgtacat ggtttggtaa aacctcttga tagagaagat gttcgtgaaa 141060 agtttgaaaa agctgaggat tatgaatgcc tattaaggta ctatcctaca gtagatgtgt 141120 ttgcctggaa ataatagttg aagcggtact tatccgcttc tcctacttag agtatataag 141180 caattgtata ttgtaagtag gagtgattaa cctacagacc ttttagactg aggtcatgtc 141240 attttggttt tgttccaata agccgaccct ttacctgcca gtagagggtt tttattttaa 141300 gtgttgacat actctaagta gtatggtatg attagtatat aaattaatag gagatgaata 141360 gttatgaaat tatttataaa tggggatgta acagaaggaa cacctgagga gttatctaag 141420 tacaagaaac tagtcgaaag tgatgtagag gaaaattact tttatattgc acatggaaat 141480 aaccaaggta tagttgttaa aaaggctaat ctccataaat tatcttatgt agatacgaaa 141540 ggaaatgtcc atatattaag agacgaagat attaagacaa tatcaaatag tgatgctaaa 141600 agggttttta gtgatagtgt agaaaaagat gcgttactga tatattatct taatttcaat 141660 acctttgaga agatatattt ttaactaaaa aataataagg aggaataatt atgaataaag 141720 tattagaatt tattttttgg tatatatggt atcttataat gggatttata ggagtatggt 141780 taggtagttt aattatagga acggatatta accctcttac tagttggata ccttacgtaa 141840 ttgctttagt aatgtctgta tacgaagtta caattagtaa gtaggaggaa tagatatgag 141900 agacttatta aacttacaaa ttatttttta tatcgtaata gggttgttac tggttggctt 141960 actgtatata cctattctat tagccctcta gagctcattt aagagcataa atacaataga 142020 ggataaattg tactagaaat ataatagaag ctctctatgg acggctgaga ggtattagaa 142080 ttgaaaggag agatataatg aaagcaacta tatactgtgc taataggtac agtaaagata 142140 cattaaagag tattttaaag aaactagaag cggagaatag aaacttaaca tatagtacag 142200 acatatcaga tacaggagaa gtggatgtta ttatacaaca cactagtcta tctttttcag 142260 agttaatgga ttcttgtgat agagtaagta aagggtctga ccgcttccaa gtatttgtag 142320 gtaatcactc agggtattat ataaacggtg atttatgtat taacgaagta ggtaagttta 142380 ttgtacctag gaaaactaat atgatgatgt agagggggag atataatgat tcatatattt 142440 gtaaatgaga actatagtaa agaaacgtta ggggatttac ttaattatat taatactact 142500 gtagacaggg aattaactta tggtattaat acagactatg ataaggatat agtagttgaa 142560 acagatgacc taatagatga ggaagatgca cttgatttat cgggtatgag tcatttcaaa 142620 gatgacttat gtattattat aggagagaaa tactgtaggg gatttcttaa tggtcaccct 142680 gctcttatac gtaactatat aagggagaga ttataatgat agagattaga ttagttaagg 142740 actatgataa aagtcaatta aagtttatat tagataaaat taaagaagta gcacctagag 142800 aattaactta tgctatagaa gcggagatga atacggtaga tgttaatatt gaagatgtac 142860 tccctcataa atcacctcat gagtatgaaa aatattcaag gttacttgaa gaagatttat 142920 ggatagttat attccaagga agttatacta cttattacca a 142961 SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Staphylococcus specific bacteriophage OPT-SC01 and antibacterial composition comprising the same <130> 1-92P <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 142961 <212> DNA <213> OPT-SC01 <400> 1 ggagaaagtt atagtggaga atctttaaat gaaattatat atgatatgtt tgaataagga 60 gatgttatag atgtttaatg tatattatac agtttaccac aagcagagta tgaagacgat 120 tcaggataag ttagataggg atagtttaat atatttctta tatgagactt ggcataagga 180 tataagtaat atatacccaa cagactatac tacgtataaa acaaaattct gtatagatgt 240 agatatagat agactaattg aagcggttaa taaagaaggg atactactta ttaaccgtag 300 ttatgacgta gagttatagg atgttgacaa attgtaagta gtacatttgc ttttctacaa 360 gaattatggt ataataaaga aaaaaataga taggagttta ttatgaagtt aaagtttaac 420 aagacagata tagatattaa ttgtattgtt tataattctg tcattgaaga ttttggtata 480 gtagttggtc aaggtgaagg ttataatatt atgtatatga atagtaactc ggaaacttat 540 gatgagctac tagaaaattt cttaatatat aataaacctt taactttaga tgaacttatg 600 aaggataata aaacattacc taaggttaca atagaataat ttaggatact gaccgcttct 660 ttgagataag gaagcggtta tttatttggg ataaaaaccg taggataaat aggatagatt 720 ccgatttaca gtaggatgcg atagggttaa gatgttacga tgagataggg ttaaatactt 780 tgggataggg tttaggttat ttttagtata gttataagta ggtaacctga atattgatta 840 gttattccgg gtaataaaaa aatacctata ctgaatagag tataggttac aagtagttga 900 agatgattaa ggttaataat tgcttgccaa tttgaacaga ctatgcccgt tacatcttat 960 ataatattta tttgtttatc tattaggatg ttatatatag tgtaatagat actgtttcgt 1020 actagcgtac gacttagctt tttagaaaag ctaagaacaa aacagcttat gccaagttgt 1080 tgcttaacgc tacgctacaa caaccaggca acgcctgtaa tagttatcag taataaatta 1140 ctaacaacta attactttgt tgtttagatt atatcatatg tttatgagaa tagatgaga 1200 attgggttac agtagtgtta catatttgta aatttattgt aaatattata taggttaagt 1260 tactccttat aatttgatta catataatag ggtaaataag acaagtagat ggtcactaat 1320 agggttaata atcagaagcg gatattgtct aagtagttgg ttatttaatt gataagaatt 1380 atcaataagt agcccctctt gattcgacct tgttataaaa gtcaaaaaag gtcaagtagc 1440 aacctcaaat tccccctagt ttatcccaac cgcttcacac ggtctatata tagacaatcg 1500 taataatatc agaccgcaaa aaaatacacc aagaatatta ttcctagttc attgtataat 1560 ttttttatag gatatttact taaacatata attattttgc ctaatttcta gtttcttcca 1620 tataaaacaa aaaataggct ttaaaacttt ttaaaaaaaa ttacattttc ttattgactt 1680 attaatcatt atcctttaat attagtagtg taataaataa cacgaaggga attgataata 1740 tggatataaa agaaattgca gatactatcc aggagctatg gcagatggac gggtacaagt 1800 gtttagaacc accgttattt gaaagcacag taaaccacac acgcacacac acagctttaa 1860 tcgttagcat taaaggtaat tacgaaacgg ttcagatgtt ccgcaaaacg cctttaatga 1920 gctttaaagg gcaatcacaa ccggctacaa tgttggtcaa tgtaattgat aacgtgatta 1980 taatcgttta tgaaaatacg gtttacgggg tgaaagataa agaaataaaa tttattgaag 2040 aaatttaaaa atagggcttg accttacatc taagatgtag taatataata gatgtaaggg 2100 atagcaacac accttaaaaa ctttttaaaa aagttaaaga aaagtgttga caccttaaaa 2160 gatacatgtt attattagta tagaagttaa gacaagccac ctagcaaata acgaaaaata 2220 aactaaaagg attgattaat tatgacaaaa aattatttat acaaagaaat tacaacggta 2280 caaaatgaaa gacttacagt tttcagaata cctaatgacg taaacgggaa ccctcgttat 2340 gttgtgcatt ttttagacct aaatattaag ttatcagatt atgacaacat aaacaaatta 2400 tatggcttta aaaaatatcg tgctcaatgg tatggtggcg gggtagtatt ccaaagctat 2460 aatatacaag atacattaaa ttgggcacta gataaagtta aagaaactga agcggttaaa 2520 taaaaccgct tctgaattaa ataaaaaaat tatataaaaa ggatatgata ttatgaataa 2580 aaaattaaat gaaattatta aaattgtact ttttggaact aatgaagaaa taaatagaat 2640 tgcactcaat tatgatgtaa ctttagatga attaaaaaaa ttaaatgatt attttcaaat 2700 tcaagatagt gatgcattaa gtgttgcaca agttatggat atagaaaatt attatccaaa 2760 ttctaatgta tctacaattg tatttcataa ttatattatt gaagtgttag aagatttaaa 2820 tacaatgtta gaagtataaa aaaattatac aatagcctag gattaaattc ctaggttttt 2880 ttatttattt aaatttatat aaaaaaatta tatagttgtg ttgataaaat ttgactttga 2940 ctaactttga ccaattgcac attaacgctt taacgtggta aagtgctaat gctttaatgc 3000 tttaccatgc taaaatctaa tttactttag cacattaacg tattaacgct ttaaaccgta 3060 acgctttaac gcactaaagg atttgctaca gatatgaagc ggacaacctt attcaatatt 3120 tattatataa aaaaattata ttaaatgact ttagagcccc tctctctccc caccttgtca 3180 tattatagt ggaagggtta ggcgggttac cactgtttta ctttctatat atagtatact 3240 atgaataacc ataattgtca acacctttca gaaacttttt ttactttctt ttattattat 3300 ataaaaaaat tatagataaa aaagggctcc acttattatt atacaggaac ctacatagaa 3360 tgtcaatact tttcttcaaa aaagtttttt aaattaattt caataaatct attgacttat 3420 gttttattat cctttaatat ataggtatac taattcaaaa gggaattgtt caaatgatta 3480 ttttatggct agcttgtgaa attagacgtt tttacgataa aaagaaagag aaaaacctgg 3540 attatttatt ttaaaaaaat ctattgactt atctttactc ttgtagtaat attgatatat 3600 accaattag aggacaacac aaaatgctaa aatttaaatt caaaaacaaa acaattaaat 3660 caactcaaaa aacagataac attattttac ttattatagg tggtttagtt gcaacagtca 3720 cacctaaact tgtaaattgg tttttactac tacaagataa catcaacatt tttattaaat 3780 aagtgttgac aacttagaaa taacgtgata ttattaagat aacaaataaa acaactgaaa 3840 aggatatgat gaaaatgaga aaaattacaa caactttaaa cttaatcgga atgagaaaca 3900 atgaaaggtt tacagaagag ttaaaaaact accgtcaaga tgttacattt ctaaaagcaa 3960 ataaaattgt aaaatattca aaataactat tgacaaccta aacattacat gttattatta 4020 atatatacca aatgagagga attgatttat tatgaatgaa caaacaataa tagaggtaac 4080 gtatttaatt tcaaaagata gctacacact caaaggaaaa tcacaaatac aagaggattt 4140 acaagacaat ttagaaactt tatatatgta tgaggatata caaacagaag aggaattgaa 4200 cgaccttata aagttgattc ctaataactt tgattatgtg atgaattatg tttgtgactt 4260 aatggaactt gattacaaat atttagaaat ctaaaataag gcttgacttc caagccttac 4320 catgatatta ttaagataac aaataagaga ggaattgatt aattatgaaa aacacattaa 4380 acaacgtaat tgaaacacta gaaagcaaag ggtacgaatt tgagtacgat gaaactgtta 4440 cagtattaga aatcacaagc cctagtggtg cttatgagga catcacacca agctttatac 4500 gtgacggaaa agttgaaagt ctttttatta ttcccgactt tttagatgaa gacctaggga 4560 acgtatgtat tgacttttat ggttatactt taaacttccc aaatgctaca gaattattaa 4620 atgaaattga aaatactttt aaataactgt tgacaatcta gaaacaacat gttattatta 4680 aggtacaagg taagggaagc ggtcaaccgc ttccaaccta gtaaaaaaag ttttaaaaaa 4740 ctattgacaa gtcacttagc cacatgatat aatgaattta acaaataaaa cagaaaagga 4800 attgattata atgaaattca tcaaaactat tgaaaactta ttaaacaaag ctgaaaacaa 4860 agggcaagca attttaaacg gtcgttactt tgacggatat agcaagggtg agcttgagga 4920 aaaatacgca attgagattg acggaaacaa attggttatg agacattggg gaacacaaac 4980 aattgagatt gacttaagcg ttaatgaaat tgtttcatac tatggagagt ctaacagtga 5040 tagagatagc cttaatacgc ttgtatattg cttagggatt gcaccaaact tccgttactt 5100 accaagcaaa gatttattca tttacgaaaa ttaattaaat aaagggcttg actttcaagc 5160 cctaccatgt tattattaaa ttgtaaggta atcaagcaca cggacaaaat aaaatgtaaa 5220 ggattgattg attatgaaaa tgacaacaga aaactacaat aaggtactaa aggtttacaa 5280 agaaaataag gtgcttatag caagccacaa agaacatctt aaagccaatg caacatacaa 5340 agacttaaac gtaagactag tgtttgatgt gttctattct caactattcc cactggaaga 5400 aagacgctta attgctcaaa atgacacgga taaagaattg cacgacaatc acctacaaac 5460 cgcattttta aaggcattaa atgaaatcgg attgaaagaa taaaaaaaat taaataaagg 5520 gcttgacttc caagccctac catgttatta ttaaattgta aggtaatcaa gcacaacgac 5580 aaataaactg aaaaggattg atgtaaaatg ttcaaattac aaaataaagt ggaaattatc 5640 gtaccaaaag aggataacaa cggtgttgag attgacgact tagcaatccg tgaagaatta 5700 gaaactatta ccaaaattgc gggaggttgt acgactacag acgttaaagg tcaatggtgg 5760 tcagacgatg aacaacgtat catgcaagat aataatataa actttgaatg gtactatgac 5820 aaggatatgc aagacgtgaa cgaccaacaa agcttattga aaggcttatc taccattgca 5880 agagtgttaa tacttcaata caatcaagaa ggcattagca ttaaagttaa tggtacacta 5940 tacattgtag atgaaagtga tttaaacttt ttatcttatg aattatatga cttaatgttt 6000 aagaattaaa taaaaaaatt atataaaccg cttcggatta aattcttgaa gcggttattt 6060 ttttttaaat tagggcttga caaatgtacg aaaaaatgag ataatgaagt gatgactttt 6120 tttcgtataa aaataatatt ctataaaaaa attatagata ttttagggct ccaagtccat 6180 tatatcaatt ttgctcccac ttgtcaatac ttaaattaat taaaaaagtt taataaatct 6240 attgacaatc ctttcaatcc atagtataat atagatataa ggttaaggag cccaagacca 6300 aagaaggggt ttcggggggga gtccgtcctt ttttataaaa aaataaccgt ccacctccat 6360 tatataataa ttcctacggt ttgtcaatac ttttgttaaa aataatttat ttaaaaaagt 6420 ttcataaatc tattgactta ctataatta tactgtaata tatagagtgt aataaggaag 6480 cggaacactt aaaaaaagaa attaaaaaac ttttaaaaaa agtgttgaca ccttagcaca 6540 tagatggtaa tattaaggta gttaaaaaat acaaatcaga aaaggatatg atgaaaatga 6600 caaacacaat aaaaggattt ttacaaacag aggaagcaag cacagttaag gacgtagcaa 6660 cttacggagt acaaagcgga gcaattggca gattaatcta cacaaatgat gtagttaact 6720 tttttaatag atattatagt gatattgaag cggttgttac ggattactta gaaggcatca 6780 caggaatgca atattttgat ttattaaact atgaattaat gagagactta gaaaattatt 6840 caaatgtagc ctttgaagaa gaagacactt atttaaatat tacgttagac ctagcagaga 6900 aacgtgcaga agaagataac gaagattgga atgaactaac agaagatgaa aaacaagaac 6960 tttcactaga ttatatgaat gatgtggaga ttgatattct agaacttgat aaggttcagt 7020 ttgtatactt gtcagttgag attgtagcac aacaaatgca ggaagcataa gaacctgcag 7080 gaggcacaca gaggcacaca gagaagctta accgcttctc taatacaatt aattaggaga 7140 tgttgaagat gaacacaaga cgggtaaata aagccttaaa tgaagcaatt agattattag 7200 ataagcaaat atcagatacg cagaagacaa tgcaggagct aaacaaacaa ctagaacaac 7260 aaataaaagc taaacaggag ctaatgacat tagcggacgt tatgactggt gatgttgaag 7320 atgaacatta aagaagctca taacgttgtc agaagtgcaa agagcaaact cctgcaggag 7380 cagaagcata ttaataatgt ggtaattgat gaatacatca cagaggagct tcacagacgc 7440 acacagagaa gcggaaccat acagatgaac aataacattg cagaatatag taatgacgca 7500 tatggtagct taaaagagct tagagaagct tatgacctct cttctctatc tactggtgag 7560 attaaagaac taatcaaaac atttgtttaa aaaagtttta tcaaaacact ttacaactat 7620 ttaatttata tgctataatg aacttaacaa attaaaagaa aaggaattga tgaacatgaa 7680 agacttacaa gagagaaaaa gagaattgaa aacattacta tttaacttag ctattgagaa 7740 gaatagagca actgatgaac agttaagaga tgtattagaa caatcccatc aagaggtagc 7800 aaatcaatta agaaaagtta gaaaagaaat tgaaatttta gtcgaagaaa aagaaagaga 7860 attttggaac gatttagaat ttaatttatt agactaagag gagggcaaac gcccttcttt 7920 atttttatcc tattatataa tttttttata ttatacgggg gcaggggtaa aatgccactc 7980 aatgggggta ggtctatatg cccctacggt ctacccaggt acttattttt tggggaaaat 8040 tatgaaaata aatatttaaa agtcaacatc attataataa gtcaacatta taaccctata 8100 cttaaagtca acattataac cctactcaga aaatgcttaa taaaaaaatg taattaataa 8160 ccctaaagtc aacataccta aaataaaaaa agtaggggat aattaaatcc ctctacttat 8220 actaataact tataatctta actaagacag tttcttcatt tccacctgta ccattactac 8280 tatgacctct tattttatta tcttctatat aaataaactt agaacgtatt ccaccgcttc 8340 taactcccac taagaactta ataccaaaag aagcatacat actaggttgt gttttaggaa 8400 cataacaata attgacattg cctgatgaac cggaagtctc tttaaatact aatatatatc 8460 cattactaca ttctgataat ggttttgttg gaataatttc tttagaacca tccaatgtct 8520 ctgaacctga ccatacttca ttatagtctg tatcttcttt agcattatat aagtcatcta 8580 tttgttgttt ccattgttct aatgtttgac cgttattaag tttaatatta tctcctagtg 8640 ttataggata taaatgttcg aactgtccgg ctactttata attcatttgc attttatttt 8700 tatcccctta cctgtatatt taaataattt ttagttgggt atttaggtaa ccctgcacca 8760 taccaaaatg tatctcctag tggttctgcg ttgactgcca tacgttggag tattttttct 8820 ttaggttctt ggtacatttg tttatatagt atatagatac ctaatgtggc aggagtagat 8880 aatgaggttc ctgtgctacc tgttgagtag gaactgctaa tagctgttga gtttctagca 8940 gtagtggtag tgattatttt aacaccgcca ttagagaagt ttaatccttg accgatacaa 9000 cttgtagcgt atcttgtttt atccggatta atatttgcat tggcaatcgt gaaagggtat 9060 tttgcagggt acttagcggt atttgtagtt gtatctgttc gtggttgggt attacctgca 9120 ctacagaaaa tagctatacc attatttgaa gctatttcga atgctttttt acgagcttta 9180 gattctattc tactagagaa agaacagtta acagcatcca tcccattatc taccgcccaa 9240 ctcatacctg ctatttgact actccatgtt gtggagttaa tagcaccatt accgttatct 9300 atacggacag cataaatttt agcttcaggg gctataccta ttaaattacc atcaataccc 9360 tgggcgttaa ttacacctgc tacaagtgtt ccgtgtgagt tagctaagga gttatcccaa 9420 ggtaaagtag aatcgtaaac attaatacct gattctactt ttaggtttgt atgtttttgc 9480 acacctgtat ctagtatacc tatttttaat ccttgacctt tatacccttc tttatggaac 9540 tgttggatgt tcatcatatc gaaagcatat gatgtttggc ttgtttcata tatattaccc 9600 tctgatgatt ctacgtctgt gctctctgca ccatcttctt ctatactctc tactaggtca 9660 tgattcttta atttgaaagc atctgactct tccatatgag caaatacaat aactttcatg 9720 tggacttcta tattagaagc attgtattct tctagaaaat taaggtctga ctcttctttt 9780 aacacaataa gatatttatg cattagtctt tcacctcaaa ccatatatta ccttctgcag 9840 gttctgtact agatacaaca atgtatgcat ctgtaccatc cttaccgggt acaccctgaa 9900 ttccttgttc accttgttca cctttctcac cttggatacc ttgaattcct gggtcacctt 9960 tttctccttt agccccgtca gcaccgtctt gtcctgggac accttgtatt ccttgctcac 10020 cctgttcacc ttttaatgag tttagttggt cttctgtaaa atcttcatac ttgaagtctt 10080 ttccgggttc accttgaata cctggttcac ctttctcacc ttggatacct tggatacctt 10140 ggattcctgt gtcacctttt tctcctttaa gagatgataa gaattctgtt atggaacctt 10200 caaatccctc gttaactgcc aagtcatagg cactttctcc tgggtcacct ttttctccta 10260 tgtctccttt atcaccctta agagatgctc tttgctcttc agttaagtct tcgaaagtca 10320 ttgtaccatc ttgacctttt aatgattgta tttgttcttc tgttaaatct gagaatttta 10380 agggttctcc tttttctcca tgtaagctag ctaaatactc atctagctct ccttggaaac 10440 cttcttcgac agctaattca taactacttt taccgtcttt accatcttcc cctttttctc 10500 cctttaacac gttaagttgc tcttcactta aatcctcaaa actaaaagat tcaccatctt 10560 taccggctac acctgtttcc cctttttctc ctttttctcc ttttatagat tcaacccatt 10620 cttgttctgt tccttcaaat ccattatcta cagctatatc ataagctgtt tttgttttaa 10680 ctaatatatg gtctttaaaa taaaatgtta tttctttaaa agaggactca tgagttgtaa 10740 aaccgggtac ctctacttta tccgtctcgt atctctctgc ttcccaagaa acaaaaaatt 10800 cacccttagg gtaatgtgta tgaggtgcta agttaggtat aataactgaa cctacctctt 10860 cgtgtaattc tacattatag cctacagcta gtatatttcc ttgtctatca tatgctttta 10920 aatgtggcat ttataattct cctgttctat taaattctta cttataatat atcaaattga 10980 ataaagaagg gtattagtta ctctattatc taattcctgt tctatagtat tcatatgttc 11040 ccaaacctca atccaattta ctcttgtatc atcatagtaa aggtggtagt cctgtgggtt 11100 ttctaagtac tcttctaatt catcatagta taaaacttca aaagctgtgt cgtcaagtcc 11160 catttgaatc tttaggatat ctttataccc taactgttta ttaccacagt aagctgtgtc 11220 ctctaatctc ttctctagtt tattaaatag tgtttgtacg ccttgtaatt cattcataat 11280 tgattcctcc taattggtta tatacttagt ataaaggatg ggtattagaa tgtcaatagt 11340 tttatataaa aaaagagaaa gaatattatt cttcctctaa ggtgttatta gtaacttcta 11400 attcatgaat cgtaatcata tcttctctaa ataatggtac atcttctata ttatctttgt 11460 aatagtaagt gtatccatct tgaaggtatc cgcttcttct ctcttcataa ccatctgctt 11520 taatacgttt aattaagttc tctttatctg tatatacctt gttttctctg taagaatagt 11580 tatcttcata aggttcacaa ttatcatgtt ctacttgata tagtttcatt tatttatcct 11640 ccaataaatt tacttctaca atttcacgtt ctaaattaat attgtttggg tgactattaa 11700 atgcttcttg tgctttttct tttgcctcat tttcatcttt tgctgtaact tcatatttgg 11760 ggtgaaagaa aaacaatgga ctataaacga cttcaaatat tacttcatat ttattatttt 11820 tcatttattt atcctccttt tcgtaagacc attcaccgta ttctgcgtta aaatgggctg 11880 tgtctgttcc ctcatcttca tattctacac tataccatgc atcctcttct gtttctgcat 11940 ctatatatct tacttcttct gtagtaatag tacgttttac cttaaatctc cccatatgtt 12000 tttcctcctt agtattttcc tctagtattt gttttagggt ctgacaatct ttttggtcta 12060 aagtttgcca acgctctagg ttctgtaatt gatagtagag ttcatttaca atttcatcga 12120 aggcttctgc ttttttatag acttcctcta gttctgcttc tgctaatttc ctatcccttt 12180 taatttgttc tgatttagct actaatatat gggctttatt catttcttcg ataataaagt 12240 tcttatagtt tttcattgtg agtcctcctt atattcttta taacttttga taacaatatt 12300 acagatacct ctattaacag ctaaaaataa tagaaatgat agtagagtta taactgccct 12360 agtgtctcct gtaaagggta ataatttaaa tagtaaaata ctttctaaaa cacttgtagc 12420 tgtgataatt gtaaggtata agatagataa taagtaatcc tttaatttta gcttaacaaa 12480 aggtttttta ttatcctgtg tttttgctat accatatagg attataaacc atgctacagg 12540 tatgagttgc attataaagt cattatttat acctaatgcg tataaaccat aaatgatacc 12600 tgcggggata cctataatga atgctaagaa tacagataat ataattagca ttataggaag 12660 tgctacaagg aaccctaagc cttgttttga atactctaat gtattctttc ctaaggcttt 12720 aaagaatgtt ttattcatct tctacctcct tgtaatatac agtatctata tgagtaatat 12780 tatttttgaa ccatatggat ttatcacctt tgttagattc taaagatga gcaccattaa 12840 aaacaagacc ctcaataaaa gaatttaaat tagttttagt atctttttgt cgtacaataa 12900 tagaagaccc tgatacatca caaattctta taaaattaat atcttttgtt atttcttttt 12960 ttactttatt atttttaaac atcgttatta ttcctccttt tatttgtatt tattatagac 13020 acaatggact cgaacatctt ccattacttt acctaataga ttctgacctt tccaattact 13080 tttatctagt attttagggt catttgcttt aagacctaca ccccatatag tatcataagg 13140 tgatgcttct acgaaatctt tacgtaaatc tgtatcgagt atttcccgtt ttaagtgtgt 13200 agtcataaac ttatctttaa ccacttctac cataatgtca tatcttactt tattccattg 13260 ctcttcatta aaattacgaa ctttacgacc tagactttta gcatgtttcg gattcttagc 13320 atttaatatt tctcctgcta tctgccagtc tttaaaatat tgagccttac gccacataaa 13380 agcttgttct gaattattaa atgttcttcc tttatgttta aactttatag ggtaaaagtt 13440 agagtaaata tcttcctgac cccaaaacat aatatatctg cttgtttctc tcatttgtta 13500 ttatcctcct tataaatact tatctaaagt attttccatt ttgtctagct gttttctgtt 13560 ctctatcttt gcttggtttg atttatcaca ttcttcttta tttgattctt tgaactctcc 13620 cttatactcg atatactcat ctcttaattg aataagggtt ttaaagaaat catcataagt 13680 atttggtata cgtttactta catatcccct taaataacct gctaatagat aaagtttaat 13740 atcgtcatta ccgtaacctt caaaagagtt gagtttgaca ctaattgtga aaaagtttt 13800 aaatttaggt gtgttaaagt taaagtgtat agtatgacct ttactctcct tatcatgacg 13860 atattcaggc tctgaagcta taaaattatc tttattaagt ttttctatgt tttctttatt 13920 actgaatagt tctagtaatc tccctaaagt tactgtttcc atacttatct ctccttacct 13980 taaaaattta tttaatttat cttttttacg tttttctgtc tctaggttta ttaaatcttt 14040 ttctaatttt tctttatttt tttctttcca tatatcgtac aaatagtcta ggtactctgt 14100 aacggtatta aaatctttta ttttactacc tttactgtaa ctatcaccgt accctttttc 14160 tactactata taatcatccc caatagtagc attaatacta tcgttatctt tgatataata 14220 aatatgctct tcgggtgggg attgcatcat tacattgcca aagtaaacat actctaaggt 14280 atactcacca atttttttaa ctttacactc tctcatttca tcaaataaag ctaaaaacgt 14340 ttcataatcc ataaattaca tcctttctgc tgtataaaca aatatctaat cctccaattt 14400 aataagtggt aaatctatat ccctaaatac agcacctacg tcacatagca acatatcatt 14460 atgttcttct acttctccac taattgtagg tgtgtgaccg catacgtgaa taaaaccatc 14520 attacgtggt tggaaatctc ttgaccatag tagttggtat ttggtttggt ttttagcagg 14580 gttccaacta actccacctg aatgcgtaaa ctcatactta tcttgcttat atataacagc 14640 acagttatgc attagtattt taaactttct atagtcttca gactctttga attccctaat 14700 ttcttcaacg aatttatcga agtattctct ataaaactca ttttgattta actcaaagct 14760 ctttaatggt gttgtgtcaa taccgtacga ctctagtgtt tctatacagt accttgcaaa 14820 ccattcaaca ttatatatat ccagtttatc aatattttct atactatgcc aaaatgcatc 14880 atcatgattt cctaataacg gtataatgtc atcatcgttt gagactcttt caaaaacgta 14940 attaactacc tctctagatt tatcccctct atcaatataa tcccctaaaa atactataac 15000 atctccaggt tgtctttcct tgtctatctt attcataatt gttattagtt tttcatattc 15060 tccatgaata tcaggtacta catatatagc catttaatct cctccttatt gtatataact 15120 atcttatcat acttatttat aaatgtcaat aaaaaaacac ctattaatta aaataggtgt 15180 agaaagaact cctcgtatat taaagatata ctagagttct ctaattaatc attatgtaac 15240 gtgtgccttg aactcataaa ctcaggcact ccctaagttt tgggaatagt tttgtttact 15300 tgaggacata atatagcatc tgtagcctta tgtataacat accgactaac ctgttactgt 15360 ggtatgtgta ggctctagaa accctagttt ttatatcttc acctttcatt agatatatca 15420 ggtactttta atatgtattc tcccgtcact tatcggtttt tatttatact gtaaaacggg 15480 acgggtacca cgaaaaacag ccaacagagc tcccgtactt agattacggt taatattatt 15540 ttaagacaat tatatgagac cctctgttgt tgaaacgctc gtcactgcgt gtatgtacta 15600 taacagggag ctatataaga gtttacctca tatagctttg ccatagtaac tgaatataca 15660 gtggtttagc tgtcttatgg agttcctcca agctatacag aggaaatcag cttccttatg 15720 ttgcaactca tctaaccata aacttgagtt acacgccaag tgtctgatac ctaataatca 15780 agactcggta tctcaagccg ttactttata ctctatgaca ctccttctga atataaagct 15840 gtccgacttt tttcactctc aagttgctac ctgattttga gctatcccta tttggaaagt 15900 aggtacggtt cacctatact aatagtatag cataaataat acttaatgtc aagttaattt 15960 atcaatttaa tctattatta ctcctgaaca cctataagat ttttaagttt atctatgacc 16020 tcttcttctg tttggtaaga gaataccccg gtaatatgtt catagttacc tacaatttca 16080 taatcttgtg taccgtatct atctactaaa taagcattac ctaatacatt taaactaccg 16140 tctttataac taaaactaat attataatct actaaaaaat taataatttt tttcatttac 16200 ataacctctc ctattggata ctgacctaac attcttacac cctcttcatt ataaaaggta 16260 tactccacta caatgacatt catcttatct acgtatatag cctctatata aggtataata 16320 ttttcttctt tttgtatatg ttgccctacc atttcatata ataattctga gtgtattctt 16380 ttatctctca ttataaacct ccgtaagaaa cgctacagtt ttatctttta aagacttttc 16440 tactagttcc atagcatctt tatagtgttt tatattcgat tcattagact tcagtttatc 16500 ttttacctct tgaattaggg gttcaacttt agtaactaaa tcttttttat tttccatact 16560 tacattactt ctcttgttat ctaatacttc ttttggcata tacttaacct ttgcaaagtc 16620 tgtatagcta acatttaagt tatctaaatc atctaataaa tcattatagt attctaagtg 16680 attatagaac gtgtaaaact taacaaggtc tttacctgtt agttcctctc ttttcaatat 16740 agaattaata ttaccaataa cagaataagc tatagttttg aaattagctc tcacataagt 16800 cagaaatata aaatcatcat agaataaatc tagaacggtt ttattgaatc tagtattctt 16860 agcttgttct aattgagcac atagattaag aacattgtcg aaaccacttt ttagtattaa 16920 agaaataaat ctctctaccg catagtatct tgacacctct gtatgtttgc ttgctttttt 16980 actatttcta aaaatagtat ctgataaagg ttgaactact aggctcatat aatattcatc 17040 tgaatattca tccgatgttc cttgataggt acttccaaat tctattgtag ataataaaaa 17100 acttttttct aaatgcatta taacatcctc cttttacttg ttattataat attaacacat 17160 atgtttatta atgtcaaaca ttaaatatct tctgttgtat caatttcatc ttgcttatac 17220 ttaaaatatt cataaacttt aaataatata actcctaaag ttattaaccc taaaatatat 17280 ttcataacaa tccccccttaa taaccgtgtt tagttaccca tcctgctaaa gcatccatag 17340 ccatatcata ctcttcttca tttttaattc ttataatttt ctctatctct tcttttgctt 17400 gttcagaact aataaaatca atatcggtag cctctaggtt agttaattct aaattttctc 17460 taataaaatt cttttgacct ggtgttatag aattaactcg tacattttca tgatttaaaa 17520 attgatagaa gtccatatta ttcaccctct tttaaacagt ctgccatatc ttttaaagta 17580 ttaagtacat atttcaaatc tctatagtgg atgtcagaag aataaataat ggaatagggt 17640 gccatatcac tgtaatgtgc acaatcaaaa cctagtaccc tgtaatcacc ttcatgttca 17700 tcatacgtaa tacctccatg agaaaagctt tctatagcat taaacttctc ttcagttata 17760 tcagtaggta cattaatata accgttcaaa tgtcccattt cagggtgacg cttaaccgtt 17820 aattctatac ctttataatc tatatttaaa gttaaatcct ctcctaatat attatcctct 17880 ttggctatag ttttcataac atgttcaggt gctttttcaa acatagtatt tatacctcct 17940 tttatttata attctactat acactatttt ttatgttttg tcaacaaaaa aaggctacta 18000 attaaagtag cctaataaaa tattactttt ggtagtactt ccatttgaag taaccatttt 18060 tctgtgagaa ctcatagtga aaaccatcgt agtcaaattc aatattatag tctccatctt 18120 gaagcggttt tgaatttagt acaggactat tactctttgc taattctgct agaaactcat 18180 gatttacttt ttccataagg tttattcctc ctagttattc ttacagtatt aatatatcac 18240 aggtcttttt ctaggtcggt tttaaacttc tcttcatatg agctagcata agttacttca 18300 tatcctatta tcttagtata atctatacat agtaatttgt aattggattt tattttaatg 18360 tcttctgatt gttctatttt gttgataatt tcatctagtt catttgaaga atagtgttca 18420 ttatctacct ttattgtttt gccttgggta tagatatcaa tttcttgtat catcatttca 18480 tccttttgat tattcattat ttgattataa gtctctaaat catcaatgtt atctgtatcg 18540 gaacctttca ctaaccactc tcctctcttc ttaaggaggt catcaaactt ctcatgctct 18600 ttaattatct tttctacttc acttggtatt aaaacagctc tagcgtagtt tatatgccac 18660 atagacatat tatcaacaag ataattaacc attcttataa gttctttttc atttgccata 18720 taccaacccc cttatatcta atattaatat aagagaaaat cagacctatt aaaagtctga 18780 tttttcattt aattctaatc ttctattttt agtatgatgt atagacacct tatccccagt 18840 aagtaacgat aattctctag ctttttcttt agataaagtt attaacccat tgtagttttc 18900 tgttttacta ttatattcgt atactaggta tcctattttt tcttctaaat ctcgtaattc 18960 tccttcttta atcataagta gttttttata catcttgata tcctcagtaa gtttttctac 19020 attaccttta gataaagagt cataaacagc ctgtaaatta ccttcttcaa taagtttaaa 19080 gttatactct ccaatgatta attcttcctc agaagagtca agagttacta aaccgcttgt 19140 tgcataatcc ggtatacggt ttacaacaac accttcagtt actttgtcac ctaattcaat 19200 agtcccatct tcattttctt taaatttacg agcatcatat acttctactt tgtcacctat 19260 tctcaaatct tgagttaagt tatgttgacc tataattcta tccattactc aatctctcct 19320 ttattaatag ggtcttgtgt taagaacatt tctaaattct cttttgtaat agggaaccaa 19380 aaatactgac tgtccggagt tgaaactgtg taaaagtcct ctcctttatt tactacaata 19440 tttactggaa taaattcatc ctgcattaac cagtgagtaa caactatatc ataagaaccg 19500 tcaccactat aacttaagtc taatccatgt ttaaatgcta aatcttctaa atgttctaat 19560 aattcatttt ttgtatgaaa ttcttcttct ataggattat ctttaatagg gttaattagc 1920 tctttacaaa cgatatcgta taattcacca tctgtaactt cgtaattctt ttcaatcaat 1980 acatcttgaa ttttatcaat tgaatttgta actacttctg cgtattcttc ttctgtaaac 197440 ttacatttat ctaaatcaac atcggtaatt aattccgcaa tccatttatt taaaattgat 1800 accgccattg ttctagaaat aatattatca tatgtcatat ttatttaatc tccttgttta 19860 ggtgaatgtg gtcttctaat gaaaaatcta aaggcactac accatttctt ttagtatttt 19920 tttctttttt aagtataaca catactattg gaaaagtcaa gacagttgct attaacgtta 19980 ctgaaatttt atttaacttt ttcataacta ttctaactcc ttaagtttat tccttacttt 20040 atctttgtcg taattgtatt gtttttcagt ttctttgttc tcatcatctt cttttttagc 20100 atctatttct ctatatttag cttcttctac tttattgcca tccttcttat taggttcaga 20160 tttatctaaa tatgaattag ttttattttt accattttta tttttaccat ttttatttgt 20220 acgttttttc tttaaaaata accaaagtat tatcattata ataagtaaaa tgatgatgct 20280 caatactaca gcccaaatat tattagccat tataacctac ctccaaataa tttttttact 20340 tctcttaagt tttctgatga atcattattt atattaattc ctgtgctaga atcaaaaatt 20400 acagcattat caagtaagtt ttctttaagt tcattttcat aactagattt accggttaca 20460 ctaccataac caccctgtgt taaatcagtc atatcagatt caacttctaa tattctaaac 20520 gaaattctac gtaaaaatga tgggtttact aagtaaaacg atgatttaaa aacatttaat 20580 ctttgataag aatgttttat gttaacaaca aacccagtaa gtttaccagt acgacttgag 20640 tttgacagtt tacctaagta tagatttata ctataccctt ttgtttccaa tgtttggata 20700 gcacttaaca ttatagcacc tctataagca agattctcag ggtcttccat ccaacttata 20760 ctagaattat agaatacatc aatgactttc ttctctgcct taactctttg ttgagacatc 20820 atagagttag gtaaaccctt tatagcatta ggtacgtgag gttgataacc ttcaggagct 20880 ataaccggtt ttctttttac agatttatcc attctgaata atgcatctgt catcttttta 20940 agtttaacaa ccatgtcata agactctcta tcccctttaa ccattaagtt atatgcttca 21000 ttaaagctgt gagtgcctgt gaagtcgtag ctagctgtat ctgatgagtt gtctctacct 21060 gaaactctat tcttttttaa agcagaaaag aaatcaggta gaccatcata tttaattaca 21120 tttaattttg agttatctat taatcgtcta cccattgttt ttccccctat tctaatccta 21180 gtttatccat aatagtgtta aagtccattg aatcactaga tgaactttga gtttttcttg 21240 gttcttgttt aggctcttgt ttaggttctt gtttaatacc caaaagattt tttgttgctt 21300 ctgtgtatct gttatcttca ggtaaagaat taataaattg attaatctca tcttttggta 21360 cagacttgaa gatgatactt tctacaacaa actcgtcatc cattaccccg tctaatttac 21420 ttccattaat aattgcacgc attgaaaaga cataaggtaa tcctttttca tcattttcat 21480 atcttaattt ttgtacaaag tttaactaagt cttcattact tgatagttgg tgttctacct 21540 tattatcgta atcaaattca acttgagcaa atcggtctaa tgtagcccca tctagttgct 21600 gtctaccaac gtaaatgtgg tctgctccag ttcccatagt gttacctgct gatactactc 21660 taaagtcttc atgtgctgtc acacgaccag ttgggaagtc aaagtattta tttgcaatag 21720 ctgagttaag aattaataat acctcaggga tagatgcatc catctcatct aagaagaata 21780 acccgccatt tgtaaatgct ttgtaaaatt gtgtttcatg gaatttacca tttgcatcaa 21840 taaaacctgt taatttaaac tcttgagtta ttgcgttact gaaataaaag tctaagtcta 21900 atgcttctgc tacttgctct aatacgtggt tcttacctga acctgctcca ccttttaaaa 21960 acactggaat gttctgatta actagtttta atatatcttg gtatctgtaa tggaagattc 22020 ctgagatatc cttaattgtt tttccttctt gttgtaattc aatcttaact ggtaaattat 22080 taagttgctc ttctacatat gattcaattt gttttttaac atcagtaaga attatttctc 22140 tactttcagt tcctgctttc tcaacaattg catctacaat tgcttgttcg taaggattag 22200 agttcttctc ccctagtttc tccgatagtt cctttgttgt ttccatttgt tgttctacca 22260 atctctctaa tctttcaata gtatcttgct ttgccatatt tatcattctc ctttaatttg 22320 ttatacattt attatattac aagtatttga atttgtcaac aactttctaa aacttttttt 22380 agttactaac aaaaaaatac cttacaccta taacttaaca tagggtaagg taattgtcaa 22440 cacttttttt aaaaatacat taacttaaaa aaatcgtcaa tatctttagt tccgtgtgta 22500 tccatatcat acataaacat acaattatat gtatggttat tcactatttc tagcatatta 22560 tgcatagaag ttgcattatt taattcatct aaatcaatag ttattgtaag ttcttgtcct 22620 tcataaagaa tgtttgctat ataatatttt ttaacacctt ccattgttcc atgggaagtt 22680 tcattatgat taagaacttc tatacctaat gacggtaaat actttgagaa atagtattta 22740 cagaaatata taaaattgtc tgttctttta gacacgagta ctgtctccat actttatgtt 22800 tctttctaat cttacataat atgttttaat cttttgaact tctttatcta ctgcatcttt 22860 tcttcctagt cttgtagtat attttacaat attaaatatc atagaatcaa caaaaccgtc 22920 ataagaaaag tgttcctcta agaaggaaat aacatcctta ctgcctttgt agtgctcagg 22980 taaatgtgca tctacttgta tatcatagta gtcttctaaa agacctatac tctcaccaag 23040 actagataaa gcataaccta aatcattaga gtcattagac cattctttag atactgataa 23100 cgcatcttct ataattgtta tttttaattt atctagataa tcttctactt gagcttgtgt 23160 tttcataaat tcttttgcgt tcatttaata ccctcctaaa ttatataataa aaaaacaccc 23220 tgctcggtta caagcaaggt gaaaaaggaa agatattatg gaagtgtact atctaagtac 23280 acctcataat ataacagttt tccttgccag ttattcctta ttttttaagg tcttcttcct 23340 taacaaatac tccattaata agctttcctt tacggtcttt tatctcatca tatgccatat 23400 caatgcactc ttcaatatca atatctaatt gtaagcaaag cactgttagt actacaaata 23460 tgtcccctac gctatctcgt gttacgtggt cattgctctt agcaattccg gaagctaatt 23520 ctcccgcttc ttctaataat tttaacatct gaccttcagg tttacctgtt tgtaaatttc 23580 tatcttgtgc ccactgttta ataagttcta ctttttccat tattctatat ctcctttaat 23640 ttctgtatct ttgataatta gattatcaga gtcacttgtt acatttaagt tatcttcaac 23700 tagttcatga aggttattag taatatcttc ttcataccga taacctacac gaacgtaagc 23760 tttcactctg acatctatat taacataatc ttcttggaat ttttccattt ctaacttcct 23820 ttattatatc atattgttaa tcttttgtca attaatctga gtaatttcct ttagcaagtt 23880 ggtacttttt gtgtaattct tcatataatt tttccatatc tttatattta cgtacatctt 23940 cttcaaaatg acttaaatac tctattagta ttttaacttc ttcaggctcc aaagttataa 24000 ctggttttac catttacgca acctccctat ttgttatgta ctaatcatat catagtagtt 24060 aatatttgtc aacaaaaaag aagaactttt taaagttctt ctaagtgagt ttcgtatata 24120 acctttcgaa ttttatttag tggttctaaa tctaaattct gaataagttt ttcgtacttt 24180 ctcgaatttt taaaattgat agtatttggc atagcaagag cctcatcaac gtctttagta 24240 tagcttacaa catctgaata gatatctact tcttttacat atagaccttg agttagactt 24300 ttaaatatta cctcattatg tgatactact tcttctttct tttctatgct catttgtaaa 24360 cctcctggtc tattctacac aaacaagtac gtactctaag ctagttaatg atactgattt 24420 aatattattt aattcttgca atttcttaat atctacatca tagtttttac ttatagtcca 24480 taatgtctct cctgctctta ctttatggta atacttattt ccctttttaa taaggtcatt 24540 caatattacc tacctccttg agtaataatt agcctgtaga taacatataa gtataagaac 24600 aaagtttaca aattcagtag ctataatatg aacataggta tgtgataaaa ccatacttga 24660 tatcaatgaa gctaatccta atccaataat aaggaataga aatctgtttg ttccttctgc 24720 acttttagtt ttatagaatg ttgttatctg agttacatac gcaaggataa tagtaatagt 24780 tgctatagtt tgtgttaaag ctgtaaagtc acttaataaa aatagtaaca atgagaacac 24840 aataataaaa ggtatagaga aataatcctt ttttctatat gaagctacta ataagcaaac 24900 aatacctagc gttaaattaa gaccaacgga tactacttgg aacattgaag catcagttaa 24960 tagtaaattg taaaaactaa tacctactgt agctacaatt aaataccaaa aataactact 25020 aactccttta acactatctg atttaactaa agctattaga cctggtatat aacctactgt 25080 aactaatata gcatataata tactcaggta atgtgataaa ttatccattt ttctctccta 25140 atttctctaa tctgttaagg acttcttccc aagagataac acccttacca tttgtaatat 25200 acattactaa accataagta tatgcattaa aggaataagg tattctatcc attgtatcat 25260 tcatatcgga tgtgttccaa cgaacatcat ctgagtatac taagcatatt ttatctacta 25320 ctttttgttt ctcatcaata attccttgta atgtgtagta ttcatcatta taagttccat 25380 ccgtattcat tgataattct tgcatctctt ctaattgact aataagattt ttagcttcac 25440 gtttcatttg gtaaatttga cctatttctg caaccgtacc tctaccccct gcatctgctg 25500 taggtaaatc aataacataa acatctgctt tttcaatagc ttgggtatcc tgctctacta 25560 ttctttctgc aagcttttct tttttagctg tcttttttga atttatatca tcatttgaac 25620 taggattata aacttgcaga ccttcaatac cctctatttc ttctttttgc tgtttacggt 25680 agtcaaacat agacttatgc aacatatctc ctgctaaata tacttgttta tagtttgtgt 25740 aatccattat tattctcctt ttatttaaaa ttactgagta attaatttat agtcctccga 25800 tgtaatcgtc tcctgcatct tgactgattt cgtactctct ttcaatatct tcttctgact 25860 taccttgtaa tccttccgct acgtcaccgt attcatcaaa taaaaaatcg aaaattccca 25920 ttataaaacc tcctcaaagt catagtctaa agcatctaac acttctgtta atagtaagtg 25980 ttcttggtct aaactaactg ttgttgctct taaatcattg tctaaaattt ctgcataata 26040 gtcttctaca aaatccattg taattgaatg tccttctgag tcctgaataa tataataccc 26100 ttgacttcca tctacttcta aaccttcact ctctaatacg tttataatat tattttgttt 26160 ttctgtaatc atactaatct ctcctttaag tttatacatt aattataagc tatatcttac 26220 ttactgtcaa ctatttttta tttattttct ttattttgtt gcactactgc taataaaata 26280 atacttacac ttgccaaaaa tgctaatacc actaaaccag gtaaatttag aactgttgat 26340 aagaataatg ctactgcact tataacataa actagaccgc tcaggaataa agttaataat 26400 acgattgtta taagttttac caaccagttg ttattaataa atactttagc taaataattc 26460 ataaaaaaat cctccttagt tattataaaa taagtatacc ataactaagg aggtttgtca 26520 acatattatt ttactatctt tttttactct actaccccat attgcttatt gtactctttt 26580 aatgttcctt tatcttctaa gtcttcaaat ctttcatcca tatcgtgatt tcttaaaata 26640 ctttctacca tttctactac tggatgtctt tgaacttctg taagattaag atggtcaaaa 26700 tattttttct ctttatcctt ttcatataat cctgataata atttatatag tccatttgtt 26760 tcggggttac gtaacgtttt gtcatcacat tgtgcaaaat tacctaaaaa tataaattta 26820 ctattgtttc ctgctcgtgt agctatagca cttattgtat ttatatctag attttgggct 26880 tcatcaataa taaagtaaac atcatttaat gaacgacctc ttatagattg aatggagtcg 26940 aaaaatactt ttttcttact ctcatcttgc ccttcaaata gtaaatagtc tttaatatta 27000 ctgttactat ccattacttc taaattatct aaaaaaggtg ctacgtaagg atataactta 27060 tcctgtgcgt caccaggtaa gaatccttgt gacataccta tctcaacctg taatctagtg 27120 taaattaatt ttttataatc tttatcttct attacttttt ctaaacctac tgcttgtgat 27180 attaaagact taccgcaacc actttgacct gaaataaagg tgaatggttt atcatttgta 27240 agatactgaa aagctaattt ttgttcttca ttttttgctg ttattccgaa atatgccata 27300 ttttaaagtt cccctatcta taaatagttt tactctcttt taatatagta ctttaaacaa 27360 gttctcctgt ttccgcacag aatccgaagc aatcacaatc tacgccacat tctgcttcct 27420 caggctcctc atcatttagt gtaaactcaa caattgcatt ctctgtatta cctttagata 27480 accctgtgta aatgacttca tcaaccatat cccaatcatt atctgctaag taatttacag 27540 tatctgctac tgactcgtta tcaggtaaga agacatcatc atctgtaaac ttaattaaaa 27600 tatctccttg tggtaataca tcattaatta aatcaatttc tgtttcttct tcaatagtaa 27660 atacagttcc ttctagtttt tcaggtgtag tatgtgttaa atgtttaaca tcttctcctg 27720 attcttcata aaatccgact gcattctttt ctttgttata ctttgcaata aacttaccat 27780 tatcactaac taaatattga ctgtttgcgt tataatcttc tgcatcttct aaagtcatag 27840 atggattatg gtctctaaca taataactaa ttttcataac atctgttgtt tgtactttct 27900 taccttttcc tttaattact gaattaattc tcttcataat attttctcct ttttctatat 27960 acctatagat ttttttgcta ggttatccgc atattcgttc cactcatctc cggtatgagc 28020 tttaactttt acaaaattaa tatctattga cttttgatac tctcttacca tcttaatata 28080 tgtctgactt aaaatatttc ttgctgacca ggtaccttca taccaatgaa tgagccctat 28140 atagtctata taaacaattg cttgtttata tcctaactta atagcctcct caataccgta 28200 acaacaagct aatatttcac ctgcaacatt attatacttt attaatcctg gtttgtcaac 28260 acttttaacta atttctgata taatgttttc atctgtactt actaatacag ctcctgaacc 28320 taccttacct ttattatagg aagaactacc atcagtgtat atatttactc tatcctgcat 28380 atttataatc ctccatgaat tgagggtaat catagtcaga atagatatct cgacaaaatg 28440 ttatagaaat ataatcaaaa tcaaaacatt taaaacagtg ttcttttacc tcttctttat 28500 ttctagcaat tacattaaat ttaaaaccat ccgctattac agtaaataat cctcttttca 28560 taaaacaaat acctccacta agtttatttt aaattaataa ctaactcaat aaatgactta 28620 atcgttttgt ttttaccttc atcaatatct gagaagaagt taatcaaact atcatcctca 28680 tcaaataaat cttcaacatc atcaaattta tttaatatgt cagtaacact ataaccttct 28740 tctgatatat actcatgtaa gtcttcccca tcctctgaca gggacgcttc tattttaccg 28800 ttcttatttt caattaagta caaagtattt aataccttaa cagaatctat gactacacta 28860 taattactaa tagtaggata ttctacatag agtatttcta cattagtatt catataacta 28920 tcaattacag aattaactgt atctcttttt aattcagata cattatgttt tcgtatagta 28980 gggaattctt catcatactc tactaattct tttctatctg tattcaataa cttatctaaa 29040 gaagataata atactatttt atattgatta tcaggtagac tgtctgtaat ttccattatt 29100 gttaaaaacg tatcttcacc taaaactttg tttatgtctt gtaattcaaa tgaatctacc 29160 atttcaatag tatcatctat atcatctgta gacattaaaa aattaactag attattattc 29220 tccatcgtct tcctccaatt ccttaaataa ctctttacct ggtgtattta acgctttctc 29280 taacctcatt aaattagcac ttcttggttt ctttttacca tattcccaat aagatataag 29340 agagtaatga acacctattt cagaagctaa acttcttagt gtatgtcctt tttctactct 29400 aattttctga aggtttagag gcttactttc ctttttttca tccataacta tttctcctct 29460 acttttaaaa atttaaaatc cccggatgtc tttgaatttt ttagtatata ctcatgtgat 29520 ttgtctcttt cctctgcttt acttttagca taagtttcta tacaaaatac atgagatttt 29580 ttcaaatcag gtgactcata tctccaataa actttaaaaa gtagggtttc tttttttaga 29640 acattaatcc gaaaccatct tttaaatttg ttcatttatt atcctccttt atttatttgt 29700 taaactaatt atagcacagt taacttatga agtcaactat aatatacaaa aaaagactaa 29760 gaaattaatc ttagtcttaa tatattaata actattatgt gcgttgtggt atgcaagagc 29820 tcctgatgtt gaaccgtaac ggtcaatcat atattgtttt gcacctttag tttgttctgc 29880 tatagaacca ccactccatg atttacctaa tccttggaat aatccttgag ctcctgatga 29940 tgcattaaca gcattagggt tcattgtaga ttcacgcata gcaatttcaa tcattgcctc 30000 gtctccacct gcttgtctaa tctgttctgc tacagagact cctgtagaac tagttgattg 30060 tgtaggttgt ttagtttcct tttgaactgg tgctgatgtt gtttgtactt cttttttagt 30120 atcttgttta ttttgagtat caaattgtgc ttgttgttgg tctacttttt gttcaggtgt 30180 ttgttcttct ccggctaatc tagatactgt attatctact tgagttgaac ctgaatgata 30240 ttcgtaaccg aagttaccgt tataattata gaaatgataa gtaaattcac catcactaaa 30300 tgagaaatca tagttacctt cttgaattgg tttcgtatta acttctactg aatttgattt 30360 agcttgttct gctaatttat tatagtcaat ttcgtctgca ctagcttcgt ttgtagtaat 30420 acctccgaaa gtaatagctg tacctaatgc taatgttgca aaaattgttt tcttcataaa 30480 tttaaaactc cttaatattt tttaatatat tttttattac ataggtaatc ataacatata 30540 tttttaaata acgcaagtat aatatagcac tatttagtgt aatattatta aggttttgtt 30600 acaaacatta ccattgtcag ataattaaaa acaaaaaaaa agagaggtat taacctctct 30660 ctattattta cctgttacat ctacgatagt tccgtctcca ccaatttgga taggttgctt 30720 accgttccat ttttcaatta attgttgttg taaaacttca tctgttaatg attcacttct 30780 gatatcatta gctttctttt caccttttgc ttctacttct ttctttttag cattttgttc 30840 tgcaatttgt ttatcaactt tagtacgttc taactcttgg ttagctttaa cacggctgtc 30900 aattgctttt tgagtattct tatctgcttt aggactagat aatgcaatat cctcaattac 30960 aaatccttgt ttttctaagt tttcattcaa gctatctaaa gtatcttttt taatttctcc 31020 tgtcttaaca ccaaatgcat caattactga gtatttagat actgcttgac gtacattatc 31080 ttgtacccgt gaacgtaagt aacctttttc taattcttcg atatctgcac taccaaaacg 31140 attaaataaa gctacagctt tagttgcatc tactttatat gaaacatcaa tatccatttg 31200 taaattctta ccatctgaag ttgccacatt taaatcttta tatttatgtg tttgtgtttt 31260 agtaggatat ttatttactt tatcaaaagg tgctgttaag tgccaaccag gtgatttggt 31320 ttcttccttt acaccattta ctgaatatac aacaccaaca tgaccttgtg gaacctttgt 31380 gatacacatt aataaaataa taaatcctat aattgctaaa aaccctaata ctcctgaaat 31440 aactactgac ttcctcattt acatttctcc tttttctatc tcttttatta aactatttaa 31500 agctttttct tcttggtcta tttcttgttt atcggctcta gttacaattg attgtctacg 31560 gtcatttaag aattgttttt tatattttac atattgttct aaaccgtact catctaatgt 31620 accttgccta actaattccc tgtattgttt tcttatgtta cttttcttct ccttcattga 31680 aagaaaatca aatacgtaac ttataccaaa acctacaagg actagaaaaa caataaaaat 31740 agcaaagtat gttaaaaata atgccatgta attcctcctt tatttgatta catatataac 31800 tatacactat gtattggatt ttgtcaacac ttctttgcaa aaaaaaatag acggatttta 31860 tatccgtcta aattcctatt ctacttgaat atcccccagg caactccagg tacatgtgaa 31920 ggtggaacgc cttgacaagt tctaacaggg caatatactc tgttaccatt gtaagcatta 31980 taacctatcc aaatgtgtcc tgcttggata caaacttcgt catatacaat tgtagctcct 32040 gccggtaagt tacctcctac cggagcattt aagaatggag aacctattct agttattata 32100 ggttggttac cattaacgaa tgttgccgat tccggtttgt accaagttcc gtattggttc 32160 tttttccaag aacctacaac tggtctagtt gccggtgtac ttgcactact tgttttatct 32220 tttttaacta cagtagaact tgaagttccg ttactcatgt agtttttaat ttgtttaatg 32280 aaataatctt taagtttatt cattattgct tgtgatggtc ttccttgtgt tactggattg 32340 aatcctgtat gaagaaccat tgaacggtga gggcacgcag taggaacgaa ttccatgtgt 32400 aatcttacac ttttacggtt aggtgtaata ccccactctt taaatttttc tgctgtaaat 32460 tggaatactg cttgttcgtt tttaaggaat tgagcatcac tagcactcat tgattgacag 32520 acctcaatgc ctgcaaatct aaagttacct gagttagctc ctgttccatc acccgtatgg 32580 aaggcaattt gattcttagc atctattgct tcccaaatat aaccttctga accgtagtaa 32640 tgtgcaatac cgttaaagta tctttgttgt cctgcattag ctaaagagtt ttcatattgt 32700 tgtcctgaag aacgacccgc atcgttgtgt atccttatgt ttcactagtt cgttaatcta 32760 gctctaggta tttcctagca ccctcattac aaggcgtgag cagactattt ctctctatct 32820 cttagagata gttcttcttt cgagttcact tgaaccctac gaggaggcaa tcctctagtc 32880 gttgaacatt ctccttatga tttttctatc acttaggagt agtgatgcta aacaaaccaa 32940 tccttgaact tgttaaacct tcataaagtc ttttcagctt tattgtggta tcaaggctct 33000 aaggttcttc aaagcaattt atgtttttag tacatatacc tcacgatata tgcagtgcgt 33060 tttacaccat tccttcaggt tttttaccac gtttatccat agtataattg atatggttct 33120 tagaaacttt tagttttgct ttctttttag gtgcaggtgt tttacttgca cttttcttag 33180 tagctgtttc ttttttaaca gtagttcctg cttttacagg tatttcaatg aaatgagtta 33240 atccgtaata attatctaca cgttttgtag gttttttatt agcgtaaccg ttccagtttt 33300 gctctaaaat agtaaatgtt gaagtattac ctccatcata tacaatccct atatgacccc 33360 actgtgcata gctaccggat gtaaatactg caatccaacc ttttttaggt actgtagaag 33420 gtttattttc atgtatttta aatccagtac cataactttg tttgatttgg tctttagcat 33480 taccccaagt tctaacttta ttatctgtta accataatac atagtctgta ataaggtctt 33540 ggcattgagc gtgataatcg tttatatttt atttaatgcc tttctgtgta ataatttctt 33600 attacatttg tttaacatta aatagtttct tttttagaaa ccttatggat ttcccataag 33660 actagactat atcttaatta attgacaaaa caccattttt cttttattat atcaagaagg 33720 tttttatttg tcaattaatt ttttgcactg tcttacaatt gtaagctctt agtcgttgaa 33780 gcttctacta cttttaccat agtagcttgc ctgcggatta cccaatcttt atctttttta 33840 ctataccaaa cacatactg tttgcccttg gttatgtcac cataccaagt tagtagataa 33900 agctctaagg gcttccccgt caattcacaa aattttacat gaactatttt attaatccat 33960 ccgcatcaat tgctcctgcc tccattacac caaatgaagg gtcataactt gttgctttct 34020 taactctata aggactatct actgttcctt ttgcatatgc gtctaaacgt ttatttattt 34080 ctgcttgcgt cttagccatt acttaacttc ctcctccgca aatactttac cgtgttcttc 34140 ggtatcttct tcgtcttgag aaggtgctga accgccatca atttcatctt caatagcagg 34200 tacttcatca ctatcatctg tatcaggctc tgcattattt tcgtagctgt ctagttcaaa 34260 agtactagct gtgcttgcat ctgcttgcca ttgaacaaat tcattagggt ctttactatc 34320 acgaggtttt gtatagtctg tttgaacaat atcactatct ttaatacctt tagtattgtt 34380 atcaacaata atacctaaac ctgctaataa tgttagtata gaacctacga tattgacacc 34440 ttgctcaatt tgagctgaat agtctaaacc aaaagcacct gtaatttgat tagcaaatac 34500 tgctactgct gatataattg ctacccaaaa tgttttactc ttagttcgtg tgctaaggtt 34560 tattcctcca acaactgtag gttgtttagt ttcattagcc attaaaaaac cgacctttct 34620 attatattta tttctaacaa taatataaca gtaggtcggt catgtttaac tatattaatt 34680 taacacttac tcgtttattt gatttaattt tttaataact tctgacattt gtttattgtc 34740 taaatcttct aatttagttt caggtaatag ctctaattta tcccaaactt cttctttatt 34800 agaaacttta ttattgatta ttgctttacc tactaaactc tctgtatagt ataattgttt 34860 tgctgatgcc atttatatct ctccttttaa atatgtaaag taatttagtt tacgacccat 34920 acgagactcg aactcgtact ctctgccgtg acagggcagt gtgttaacca gttacaccaa 34980 tgagccaaaa taaatgctat accctaacct taccttaatg tatagcaggt tttctcttag 35040 gttcgaagca acgattatta ccactcataa caactatata ttaagtgaaa ggaggtgaaa 35100 tgaacaaagc gtgataattg gtacctaaga aggaaatatg tataatctac aaggagtaag 35160 ttatggttc ataaaggagt gtgaacaata aatacatgaa agagtgaaaa tatactcctt 35220 gtagattctt ttttaattat caatcaaagg aggaaactga taattgttaa taataaacta 35280 taaagaggaa aatatttata gtcacattct gatataatgc aactaaatat ccaagcataa 35340 ctcgtctcac cgagaaccta cctataagac ctgttattaa gttaatcact acgcttgact 35400 ctattagga gctaccttaa gtccatctca cgcaatccaa aaggataatg tgatactaac 35460 atattagtta gtaactttca catggtcgaa gaaataatct gtttggttaa ctaattattt 35520 ttaccaaata tatctttcga aactgtagat ttatgctact catactgata acctctatta 35580 tctaacacat ttctgtgctc caactacagg aagttgttac agcgtatctt cctaggattc 35640 cgctaagacc ctaaaaagaa attaaactct agctgttatc atactctaca gaccttataa 35700 gtaagtacca agtataccaa tcgtattaaa caatactaat gacgacccat cttaccgaaa 35760 taactccgat aagttttgat tcgtttgatt atcttgtacc ttatgactac caaatcatta 35820 ttcagtcact atgctcagat atttagttgt attatttata tattaactat aacataattt 35880 ttactacttg tcaagttaat ttcaaaaaaa ttatagaagt agggacacgt acctacttcc 35940 atttaactta cataaggatg tttacattgt tattgtttga actggaaaac aatgtaagaa 36000 aaaacagtga tgtgtaaggt atttgtttta ttgttaatta cattatagca tatactgata 36060 cctttgtcaa gttaatttaa tacttttttt aaaatattat ttatcttttg ttaattcttc 36120 ttgaatagca tcccatcttc tttctgcttc actacgatta tcttctacat gttttgtagt 36180 tttacaacat ttgatacaat atatatcttt gatatgacct tcttctcttt tatttgctct 36240 ttttcttggt actttgaata cattaccaca ttctttacat attaaacttg agtaaaacat 36300 tttttgtctt ttcataatta atcaattcct tttctttaaa tataatttaa gtatagcagg 36360 tgttgaacag taagtcaaca cctttatttt aattctttaa tttacaatcc tgagaaggga 36420 ctactataag aatctaaatc tatagaatat ctgtcttcta tatttttaat agcattaaac 36480 atcttttcta catactccac atcagtacct atagtatcta gtatatttga attttctatt 36540 gtactaatag gtacattgtt actttccatc tttttaagtc ttctagtatg cttagattta 36600 atatttatat tttgagaata taacatttct ctatatactt cgttccatgc tttaccaaaa 36660 ttaggataca taacactgct taatttaggt gctaattgtc taactctttt attagcttct 36720 tgcttccaat cattattttc aggtttctct tgaagaaact ctaatttatt ttctaactct 36780 attatttcat attctgcatt ttttagcttg ttattttctg ctcgtagttc ttgaactaat 36840 ttgttaagtc tttcggattc tgtataatat ttaaccattt cgttcctagc ttcctgagga 36900 ttatctataa tagctttagc aaaatcatca ttaacataga tgccatattt tctgatgtca 36960 ggtaaaactt ccttagtaac ccattttcta aattttttag ctgattctaa ccttgatgag 37020 aatactagac tgtataaacc ggactcattt atcagaatag gtttttgttc ccttccaatg 37080 gagtcacgaa ttgttacccc atctattttt tcatctaagt ctacatggtc tattaatgct 37140 tttcttgtgt ttgagtatcc taatacttct gcaacatctt tacctacaaa ataaggattt 37200 ccttgatatt ctacaactct tacttctttt ccttgatagt ttaattcttt taataaatcc 37260 attttaaatc attccttttc ttgttttatt tgatagttta actatatact atattgataa 37320 ataagtcaac agttttttaa aaataattta aattattttg aagaatcctt taataccaag 37380 ggttacaaga gaaaaagtac gtatttagaa aataaggagt actcctatta tatataatta 37440 tattctgata taagtaatta ataatattaa atatattaatt ataattaaca agaacagaaa 37500 aattactatt ctgagtaata atttatattt atctaaagta aaatcccttt atatcagtac 37560 ttacagaaga aaaagtacgt atttagaaaa taaggagtac tcctattata gttatatata 37620 tatattatta tacttatta ttaattacta atatattaata tataattaac aatgttaaga 37680 agtcaacaat aagacaaata aaaaagtgac tacttaaagt cactcaataa ttaaaataca 37740 attttaaaag attctattct tttcgggtta atataaactt gaggtgaagc attattactc 37800 tcagtaaata ctttaattga tacagaatca acaccactaa gcatataatc tatgtcttgc 37860 ctactataac tcttttcatc agtagatact aaaaaatact tagcaccact tgacattgtt 37920 atttcaatat gttttgacat ctacaatctc tcctatgcaa atttgttaaa gacaaaggat 37980 aatatagctc ctagaacaag taaaagaacc ttctcagtag tatccttttt cttggtatcc 38040 ttagtttttg tactttcagc aagttctgaa atcttttcat caagtctttc taattggacg 38100 taaattgctg attgtttttc actattgaca gctacatctt tatctatact aactatcatt 38160 tttcttagtt cagctacctc aacttctaaa tctctgaaag ttcctctatc tatataatta 38220 ccttcttgta tcttagactt aatagaatct acttgagaaa caaggttgtt tatttcctta 38280 tccaactaga atcacctcta aggtctaacc gtttcagact cagaatgggt atcataattt 38340 tctaagaaat cattgataat ctccatataa ttatccgtaa cgacttttcc gtaagatgtt 38400 tttgtatcaa tttcaaacct aagcttaccg aaactttgga ggtctaactc ttttattaca 38460 atatttgggt catcagaagg aaggtaataa tagtcgaagt atataattga gccatttatt 38520 aatactctgt ctattctata gacatggaaa tagcgtctgt ctcttttaaa atgagctagt 38580 gcatctttaa actctaactt aaggatatcc ttatatttag tcaaagtggt aacctcctta 38640 ctattaattt ttaattttac ttattttgtg gtataatagt tatgataaaa gcagttatta 38700 taattatatt gaggataatg ataataatta ttttttctga gaaaataagc caaagactaa 38760 aaacagataa actatagata gctgatagat atactatatt aatagttatc ttacttttat 38820 cttttctata gatagaataa cctaaagaag ctgtaacacc actaagtata aaataataga 38880 aacaaaaaag aggtatagac acaaaaaaag atacgataat cattgctaaa cacctatttc 38940 ttttgaccta ttatttctag aacttttaga ttacaccact aatataacat taaaagacgg 39000 tcataaaagt caattgttag attaataata taataaaaaa agacaatagg aggttaaagt 39060 ggttgaataa taacatagct atattcatat tcaaaacttt ggttattatt atattcttac 39120 tactaatttt gtctgttatt aattccttgt cccttattta ctcaataaga ccgagtgtag 39180 ttatgacata ctttaccttt ggtggtatta tttcttatgt cgcacttact ataatagata 39240 agttcttact taagaaagaa gaccccctac ctgaatatgt tcttaaacag gtagagataa 39300 atgataaaga aataagaata atcaagaaaa tcatagaaag taattacggt ataacagcag 39360 aagagataaa agttagagct aaagcccaaa gaagagtaga ggaagatagt aaaagggaag 39420 attacgatga aaacgaagaa agaaattaaa gaacaaagga aagaacttaa ggacggtgct 39480 acaactgttt ctttagtaaa aaaaggagat aagagaatag ctagtcctag tagaatttgt 39540 agtctatgcg gtcagcagtt atcaggtatg aattacacta aagggaaagc attagcaaaa 39600 gttaatcatt ttcatttaca gtattctaag tatatttatt ttgatatctg tgctgatatc 39660 aacaattgct ataaaaattt aagaaaacga ggtgaaatgg attgagtgca gaaaatatta 39720 gagatataat taacaagaaa aagttagaag aagaggatac aagaaaatat atagctgatg 39780 gattatgaa tggtatcggt aaattaatgt atgaattcaa taaaaaagta gataataaag 39840 aaatagaagt taaagaccct aacgatttat ataaactatt tgtgatattc tctcaaatgc 39900 agaatatggt taatgaaact tctgaaggtg gagcaatccc tcaactatct agacctcaac 39960 aagaattatt tgaagagatt acaacagaag atagtaacgg agagtctaca gtagacttac 40020 aaaaaatatc agaaatgtca gcggaagata ttacagaaat gatttccgag aaggaaagag 40080 taatgaatga ggaaaattct gagacattct aaggagaaag atataaatgg atggaaaaga 40140 actaattaag atagcacaag aaacatttca aacagaaaaa ataacaagag aacaggtaga 40200 ccatataatc aatatgttaa acccttctac ctatatgctt aagtatcata ctttgagggg 40260 acaccctatt acttttagta ttcctaatag ggatagaagt aaagcacagg ctcatagacc 40320 ttggcaagtc cgtaaacata ctatgcggac tataaacctt ttctaaaatt gggaaatcct 40380 aacaagtaaa gttgaggaca atcaattgct aaatcgtaac taagataaat attttaatta 40440 cgtaaatgcc taacgactaa atttccaagt aagcaataaa atggtattgt gtagaattgg 40500 aagagaggga aaccgtaacg aaagggactt tacgcctaa ctgtaaaagt atgatatagt 40560 ctaatcccct aataaatatc gggaaaccga gggtattaaa tgatagtaaa cgacactcat 40620 ccaaataaag cagtaataaa aagcagacag cttggtttga gtgagatgag tgtaatggaa 40680 atggttcatt ttgcagatat gtatagttat aaatcaccta aatgtcttta caccttcccg 40740 accaacgagc agatgaaaaa atttgttcaa tctaggttaa atcctgtatt agagaaaaga 40800 tatttcactg atatagttaa ttgggataaa gattccttag ggtataagca aataagaaat 40860 tctagcttat tttttagaac aagcagtaaa cctgggacag tagaaggtgt tgatatagac 40920 tttcttgcaa tggatgaata tgagcgtgta aatagccttg ctgagtcttc tgcactagag 40980 tccatgtcaa gttctacatt ccaaatagta cgtaggttct caacaccttc agcacctgga 41040 atcggtattc ataaacttta ccaacagtca gaccaatggt attatgcaca cgtttgtcag 41100 cactgtgatt accataatga gatgaaatat gcaccgtacg atgaaaataa cttgatggaa 41160 agcggtaatt tattattagt taatcctgat ggtatagatg aaacagcaaa aacagtccaa 41220 gatggtactt accagtatgt atgtcaaaaa tgcggtaaac ctctagatag atggtataat 41280 ggagtatggg aatgtcgtta ccctgataga accaaaaata actcaggtat tagaggttac 41340 tatattagtc agatgaacgc tgtatggatt tctgcagacc aacttgttga aaaagaaatg 41400 aacacagaat caaaacaagc cttttataat tattcattgg gtaaataggt agccccttta 41460 tatagtaatg tgtatcgaat aactctgtta aacagggaaa ctctaagtgc ttaaataagc 41520 atatgacaat cctgtgctaa attcttaatt taattgttga caaaataata atgtatgata 41580 taattaaatt aggataaatg cctaacgact aaatttctag gtagctatat aaacggatat 41640 agtgagaact agataaaaac taataatttt ttaaacttaa tatagaagaa aggaggaaat 41700 acaaaatggc aagaagaatg acaacagagg atttcaaaca aagaataaca gcaagacag 41760 atggagaata tatagttctt agtgaatatg ttaataacca aactaaggtg ttaatacagc 41820 ataaatcgaa caactgtaac aatcatcagt attgggtaaa acctaaagga atactttcag 41880 ggacaagatg ccctgcctgt aataataaga aaaaaggtaa aaaacctaag acaaccgaac 41940 aattcaaaaa agaattaaag gatatggttg gagatgaata cacactagta ggtaaatatg 42000 caggagtatc caataagatt actttactac atcatgaatg tggtaaagag tgggaagtta 42060 cccctaacgc ttttatttct ggaggctcaa gatgttggta ctgtaatata aaaagacata 42120 acctaagtca aagaaagaca catgaagtat ttgtccaaga ggttagagac aggtacgata 42180 atgattacaa agtactagga acttatatta actcaaaaaa taaagtacta gttagacata 42240 aatgcggaac agaatgggaa ataaaaccta atcatttact gtcaagagac atgtgcccta 42300 catgtaagat gtctgtcgga gaaaaacatg tagaaaaata tcttaatagt agagatatta 42360 agtttgaacc tcagaagaag ttttctgact tagtatataa aagaaacttg tcctatgact 42420 tttacttacc tgaattaaac atcttaatag aatataatgg agctcaacac tacatgccaa 42480 tagagagttt tggtggtaaa gaggcatatg agcaacaagt tataaaagat gatattaaaa 42540 gaaagtatgc aaatgaaaat gggtacaagt taattgaagt taagtatact gagaagtact 42600 ataatactat agcaagatat ttagataaaa aattattagt gtaaagcaga gagcccttaa 42660 cctaaactaa gggttatgat atagtctaaa ccgtaaataa atactaggaa actagcggta 42720 gtaattgatg ccttttgaag atgttaaaat gcgtgtttta gaagaagatg tatttgaaaa 42780 taaatcacct gttgcagaaa aacaattaat gagacgagat agatatacac atatttctgt 42840 aggtatagat tggggtaata ctcattggat ttctattcat ggagttttac ctgacggtaa 42900 aaaagattta attagattat tttctgtcaa gaaaatgtct agacctgata tggtagaggc 42960 agatttagaa aaaatcattt gggaaatatc taagtacgac cccgacatta taattgcaga 43020 taacggtgac tcaggtaata atgttttaaa actaattaat cattttgggg aagacaaagt 43080 ttttggatgt acttataaat cttctcctaa atccacagga cagttaagac ctgaatttaa 43140 tgaaaataaa aatacggtta cagtagataa attaatgcag aacaaattat atattcaagg 43200 tttaaaaact aagaatatta gaatgtacca agaagtagac gatgatttaa gaactttctt 43260 aaaacattgg caaaatgtat taattatgga tgaagaagat gagaaaacag aggaaatgag 43320 acaggtaatt aaacgtaaag gtgacgacca ttgggctcaa gcttctgtat attctaatat 43380 tggattaaca agaatacaag aacttcttaa agaaggaaac ggtacaagct ttggttctac 43440 atttgtttct actgattata atcaagaagg aaataaacaa ttctactttg atgaatagag 43500 gtgaaataga cttgacaaat aaattatttt atggtacaat tagtaatgaa gaaattaata 43560 aaagtgtatt gaatttgtta ttgggtgagg aattatcttt agactatgtt tctaaaaata 43620 gtgattcctt agatgttaaa tacgaacatg tttataaatc tctaggattc gataatttct 43680 ttgattgttt tttatatgct aatagagaac ctgaaatagt ccacaaaggt ggagataaaa 43740 atcttggtag gctaaataag gttaaacgta ctgttattcg taatggtaaa gaaatgcaaa 43800 tgacagttta cgaagacggt aataaagata atgatagtaa tgaaaaacaa gaaggaaaag 43860 aagaagttag tagaagtgca gtaggagcaa gagctatttc gaatggtgaa gaaggaaagg 43920 taaaccctaa aaaggtagca aattcattat ctagtttaag taaaaaaggt gtcgatgtat 43980 cacatgtcag tacaaactca ccattgtaca aagagtttgt tgatgataac ggggatacat 44040 taggaattac atcttttaaa agaactgaaa atgatataat cttagactct tatgcaagtt 44100 cacctgattc agatggtgta ggagcaagag ctattatgga attattacgt ttaagtatta 44160 aggaaaataa aaatgcagtt gtgtatgata tagaattgcc cgaagctata gagtatttaa 44220 aaactttagg atttaaacct aataaagatg gatacatctt aagaaaaaaa gatgtaaaac 44280 aattcttagg tgattatagt gattttattt agcactataa tcatctattc tattgtattc 44340 atattatata ttataataaa attaatttat ataaagtcta atatgagtag aatagataac 44400 acaactgaat tattaaagat attacaggaa gatattgaag gtaagataaa aaaggaagga 44460 agaaataaat gactttagaa gaaaataatt taacattaga agaatcaata actccactta 44520 gtaaagaaga gaaagaagat agtattaaag aatttagtag cttattatgt gaaatggtaa 44580 atagactata caagtcttat aacgtattta gacaagaccc tatggatgaa acgcaacgac 44640 tagatggttc tctaatggta tttcaaagta gattaaatga cccattaaca ggagatttac 44700 atgataagat gtataagctt gctttttcaa aacgcattga tatttttgaa gctaacaagc 44760 aattcagaaa agatgtagaa ttaggtaaag caattgagct aggtgatgta gctattatag 44820 atacagcatt aagtaacatt ctttcaggta atgagttcca aggaagtatt tcttttatgc 44880 ttagaaaaga ctttgaagaa aaagaaaaaa ttagaaaaga agaagaagaa aaacttaata 44940 acttataaaa aggaagaatt atgagactat ataaaaaaag aggtatcata attgaaaaag 45000 aaaccacaag gcaatgagat aatcataacc ataattacgg ttatgatagc agtatttgta 45060 gtcatcatga ccatattttt taataaatat caagatgcta aggaagataa agatagatat 45120 cagagaatag ttgagattta taaaaaagca gatgataata atggtgagac taaaaagaaa 45180 tatgtaaaaa gattaaatga cgctgaagaa gagcttaaga aagttaaaaa agaaacaaat 45240 tataagggtt ataacgagaa gtcaaaaaaa gaaagacaaa aggaagataa aaaaactaga 45300 gataaaatat atgatgtaac cggtgacgat gatttaatat tagtaaaaaa taatattgag 45360 tttagtgata aagtagacaa tcctgaaata cttattagtg aagatggggt tggtacgata 45420 actgttccta cagacagtgg ttatgaaaaa caaacagtag gttctattat tactagtgta 45480 ttaggttccc cttatctatc tcagaatcca cctagtacag atagtttagg tattattgat 45540 agtaatgttt atccaaacac agcagatagt gtaccaacag ataaccctac tataacaaat 45600 ccagttaacc cagtggatat attacctcct acggataatc cttcagttgg cactgtacca 45660 acggataatc ctattataac aaacccagtt gaacctgaca caccttcaga tatattacct 45720 cctactgata atccttcagt tcctatatta cctggaaata ccgaagacaa taacgcagga 45780 aatacaggaa atacaggaaa tacagataat ccaaatccac cacctccagg atatacagat 45840 gaggatggtg gaaaaggttc aggtggagga ggtaatattg aaccaccacc aacagaagaa 45900 ccttcagata atggtaatac aggagacaat gaagaagaag tgactcctga acctgaacct 45960 actccttctg aacctgagac tgagaaacct aacgaaaaac ctgatgaggg aaatgaagaa 46020 gaagtaaccc ctgaaccatc agaaccaaca gataaccctg atgaaaatgg ggcagaggaa 46080 actgaaccat ctgaacctga aacaccatct gagccggacg ataaagcgga cgaagaagat 46140 acaaatgaag gtacatcaga ggatgagcag actacagaac aaccggacga taatactaca 46200 gataacgaag ataaaattga agaggagtaa ttactcctct ttttttgcta tattaaataa 46260 gagataaata taaaaaaatt gaacattacg gtggtgaaaa ctttggtagg aatgaatgtt 46320 ataacgtcac tatcagtagt atttacctgt ttaagtcttt taactttaat gatttttgtt 46380 cacagtaagt tctccagtaa aaacgttttt gttttgtatg taatttatgc tataataggt 46440 ataggcacat acatagtttt aactatgttt caaacaacat ctgtacttat taaaaatgat 46500 gtaatagatt ccatagaaaa tactgaacat tatattggat tcaatgaccc tctaattata 46560 tttactataa gttttatagg tgcaatactt ggaggaatgt ggtacaagat gatgaaaatt 46620 attaaaacga gtaactttaa aaataaaaaa agacggtgaa taggttgata ttctctaaag 46680 ataaaaaatg ggatgaagca aaagatttca tcaaaggtca aggtatgcaa gataattgga 46740 tagagattgt agattattat agacagatag gtggaaaaca cgtagctgtt tttattgctt 46800 taaacaaagt aaaatatatg attctagaag caacaaaaga caataaagta atactagtag 46860 ataaagataa taatatacta ttagaagatt atgatattgt tatggaaagt aaaaagatgt 46920 tttactacat tgaagaacca ttcgaggtta aaataaatat ccctcaacat attagaaatg 46980 taacttataa taacactgtt gtattaacta cagtaagagg gagtagaggt gactagtaat 47040 tggcagattt atttaagcaa ttcagattag gtaagagcta cagtaataat agtactattg 47100 ctcaggttcc tattgatgaa ggattacaag ctaacattaa aaaaatagag caagacaata 47160 aagagtatca agacttaact aagtctttat acggacagca acaggcttat gcagagccct 47220 ttatagaaat gatggatact aatcctgagt ttagagacaa gagaagttac atgaagaatg 47280 aacataattt acatgatgtt ttgaaaaagt ttggtaacaa tcctattctt aatgctatca 47340 tacttacacg ttcaaatcaa gtagctatgt attgtcaacc tgcaagatac tcaagaaaag 47400 gtttaggttt tgaggtaaga ctaagagacc tagatgcaga gccaggtaga aaagaaaaag 47460 aagaaatgaa acgcatagaa gactttattg ttaatactgg taaagataaa gatgtagaca 47520 gagactcgtt ccaaactttc tgtaagaaaa ttgttagaga tacttatata tatgaccagg 47580 ttaactttga aaaagtattt agtaagaaca ataaaactag attagagaaa ttcatagcag 47640 tagacccttc tactattttt tatgcaacag ataaaaaagg taaaattatt aagggtggca 47700 agagatttgt tcaggtagta gataaaagag tagtggctag ttttacttct agagaattgg 47760 ctatgggtat aagaaaccct agaactgaat tatcttcttc cggatacgga ttatcagaag 47820 tagagatagc tatgaaagaa tttattgcct acaataatac tgaatcattt aatgatagat 47880 ttttctcaca cggtggtact actagaggta ttttacaaat acgttcagac caacaacaat 47940 cacaacatgc attagagaat tttaagcgtg aatggaaatc aagtttatca ggtatcaatg 48000 gttcatggca aattccggtg gtaatggcag acgatattaa atttgttaat atgaccccta 48060 ctgctaatga tatgcaattc gagaaatggt taaactatct tattaatatt atatctgctt 48120 tgtatggtat tgaccctgca gaaattggtt tccctaatag aggaggagct acaggttcta 48180 aaggtggctc tactttaaat gaggctgacc caggtaaaaa acaacaacaa tctcaaaata 48240 aaggtttaca gcctttactt agatttatcg aagatttagt taatagacat ataatatctg 48300 aatatggaga taaatacact ttccaatttg ttggtggaga tactaagagt gctacagata 48360 aacttaatat ccttaaactt gaaactcaaa tattcaaaac agtaaacgag gctagagaag 48420 agcaaggtaa gaaacctatt gaaggtggag acattatctt agatgcttca ttcttacaag 48480 caacagctca attacaacaa gagaaacaat atgatgatgg taaacaaaaa gaacgtttac 48540 aaatgatgat gagtttacta gagggagata atgacgattc cgaagacagt caatcggcag 48600 attctagtaa tgaagctaaa gaaataggaa cagatgcaca gataaaaggt gacgataatg 48660 tatatcgtac tcaaacatct aataaaggtc aaggaagaaa aggagaaaaa tcttctgact 48720 ttaaacatta attaataagc ctagaataaa tctaggcttt atttattttt ttgttaattt 48780 aattttgata aatgtaataa ctatggtata ctatatgtaa ttgatattaa tacatataaa 48840 atattaatat ttcacttaca agttattatt gttatattat taacgtaaaa gtaaataaaa 48900 taacaagtgg aggtgtagac acctttggaa gaaataaaat ttaatgcttt tgtacctatg 48960 gatttgaaga aatctgtatc aacagcttct gatactaatg agtattctat cgtttcagga 49020 tgggctagta ctccaagtat ggatttacag aatgacatcg ttaatcctaa aggaatagat 49080 atagagtatt ttaaatcaca agggtacatt aattatgagc atcaaagtga taaagttgta 49140 ggtataccta cagagaattg ctatgtggat atagaaaaag gtttatttat tgaagcaaag 49200 ttatggaaga atgatgaaaa tgttattaag atgcttgatt tagctgagaa attagaaaaa 49260 tcaggtagcg gaagacgttt aggtttttct attgaaggtg cagttaaaaa acgtaatgtg 49320 aatgacaata gagttattga tgaagttatg ataacaggag ttgcattagt taaaaatcct 49380 gctaatcctg aagcaacatg ggaaagcttt atgaaatcat ttttaactgg tcacggtaca 49440 tcacctgaca ctcaagttga tgcaggagct ttaagaaaag aagaaatagc atctagcatt 49500 acaaatttag cctacgtcac taagattaaa gattaaaaag agtttaatga tgtatggaat 49560 ggcgttgttg aagatttgag taaatctaat agtatgggat atgaggaatc agtccttacg 49620 ttacaactag ctaaaggttt atctcgtaaa gatgcagaac tagcagtaat ggatataaac 49680 aaacaaaaac tagaataggt aaggagaata cattctatga gtaaagaaat gcaaaatatt 49740 ttagaagagt atgataagtt aaatgctcaa gaggcagttt ctaaatctgt agatgaagat 49800 gaaaaaaata cagtagaagc tactgaagaa caagtagcag aaacaactga agaacctgct 49860 aaagaacctg aaaaggttac tgaagaagat gctaaagaag cacaagagca gggtgaaaaa 49920 gttgaatctg aagaagagtc tgaaggtaaa gaagatgaag aagttgagaa atcagctaaa 49980 gaatctaaag accctgtaga ccataaagac actaaaacag aagataaaga caacgagaaa 50040 cgtaagaaca aaaaagataa agattctgat gaagatctg aagaagataa agatggagaa 50100 gattctaagg attctaaaga taagaaagaa gataagaagg aaaaaacttc taaatcaatt 50160 tctgatgaag atatcttagt aggctttaaa actatcttga aatcttttga aaatttaaat 50220 gaagagaaaa aagagtttgc tactaaatct gaagttgaag aattaagtaa atcaattaaa 50280 gaattatcag ctaaacttga cactcaagat acagaagatg tttctaaatc agtagataat 50340 ggtgaagatg aagctgtaga aaaatcagtt acatctacaa atggagaaca agaaaaagta 50400 gaaggttatg tttctaagtc agtagatgcc gaagaacaag ctgaaactgg agaagcaaaa 50460 acagaagaat ctgaagaagt acaagaagat aatacattca aaggtttaag tcaagaagaa 50520 cgaactaagt tcatggattc ttataaagca caagctaaag accctagagc atctaagcac 50580 gatttacaat cagcttatca atcttacttg aacattaaca ctgaccctac taatgcatca 50640 gagaaagata ttaaaactgt aaaagacttt gcacaaattt aattaacgca caaagttgtg 50700 ttatattata cggtgtaact aaagaatata aatagggtac attttactgt accctacata 50760 aaataaaaag aacacaaatg aaaggtgata aatttatatg actatcgaaa agaacctgtc 50820 agacgttcaa caaaagtacg ctgaccaatt ccaagaagac gtagtaaagt cattccaaac 50880 tggttatgga atcactcctg atacacaaat tgacgcagga gctttacgta gagaaatttt 50940 agatgaccaa atcacaatgt taacatggac taatgaagat ttaatcttct accgtgatat 51000 ttcacgccgt cctgctcaat ctacagtagt aaaatacgac caatatttac gtcatggtaa 51060 cgtaggtcac tctcgtttcg ttaaagaaat cggagtagca ccagtatctg acccaaatat 51120 ccgtcaaaaa acagtatcaa tgaaatacgt ttctgatact aaaaacatgt caattgcatc 51180 aggtttagta aataacattg ctgacccatc acaaatcctt acagaagatg ctatcgcagt 51240 tgttgcaaaa acaattgagt gggcttcatt ctacggtgac gcttcattaa cttctgaagt 51300 tgaaggtgaa ggtttagagt ttgatggttt agctaaatta attgacaaaa ataacgtaat 51360 taacgctaaa ggtgaacaat taacagaacg ccacttaaat gaggcggcgg tacgtatcgg 51420 taaaggcttc ggtacagcta cagatgctta catgcctatc ggtgtacat cagacttcgt 51480 taactcaatc ttaggtcgtc aaatgcaatt aatgcaagac aacagcggta acgttaatac 51540 tggttacagt gtaaatggtt tctactcatc tcgtggattc attaaattac atggctctac 51600 agtaatggaa aatgaattaa tcttagatga atcattacaa ccattaccaa atgctccaca 51660 acctgctaaa gttacagcta cagttgaaac taagcaaaaa ggtgcttttg aagatgaaga 51720 agaccgtgca ggattatcat ataaagtagt agttaactca gatgacgctc aatcagctcc 51780 ttctgaagaa gtaacagcta cagtatctaa cgttgacgat ggtgttaaat taacaattaa 51840 tgttaacgct atgtaccaac aacaaccaca attcgtttct atttaccgtc aaggtaagaa 51900 aactggtcaa tatttcttaa tcaaacgtgt accagttaaa gatgcacaag aagacggttc 51960 aatcgtattc gtagataaga acgaaacatt acctgaaaca gcagacgtat ttgttggtga 52020 aatgtcacca caagtagttc acttattcga attacttcca atgatgaaat taccattagc 52080 tcaaattaat gcttctatta catttgcagt attatggtat ggtgcattag cattacgtgc 52140 tcctaaaaaa tgggctcgta ttaaaaacgt tcgttatatc gcagtttaat agaataagaa 52200 aaactgaata caagagaata gggataaact tagggtttat ccctttttta ttaaaataaa 52260 cttgaaggga ctcaataaat atgttatact ataagaaatt aatagataaa aaaatggcta 52320 ctgtttatgg tacagtcgag attgataaag acggagtagt taaaggatta actaaggaac 52380 aagaaaaaga gtttgcaaat gttccaggtt ttgaatttga agaagaaaag aaaactacta 52440 gaaaacaatc agcttctact agtaaagaag aagaacctaa agaagaagaa aagaaaacta 52500 ctagaaaatc tacaagcact actagaaaat caacagcacg taaaacaaca gccaaaaaag 52560 atgaaactaa ataaagggtg aattaaatgg ttaactcaat gttcggaggg gacttagacc 52620 cttatgaaaa atcattaaac tatgaatatc cttatcatcc tgatggtaac cctaaacata 52680 tagatgtaag ggagatagat aacttaacat tagctgacta tggatggtca cctgatgcag 52740 ttaaagctta tatgttcggt attgtagtac aaaaccctga tacaggacag cctatgggtg 52800 acgagtttta taatcatata ttagaaagag cagtaggtaa agctgagaga gcattagata 52860 tatctatact acctgatact caatatgaga tgagagatta tcatgagaca gagtttaata 52920 gttatatgtt tgtacagct tacagaaaac ctatattaca ggtagagaac ttacagctac 52980 aatttaacgg tagacctata tataaatacc ctgctaactg gtggaaagta gagcatttag 53040 ccggtcatgt tcaattgttc cctacagcac ttatgcaaac aggacaatca atgtcatatg 53100 atgctgtatt caatggatac cctcaattag caggtgtata cccaccatca ggagcaacat 53160 ttgcacctca aatgatacga ctagaatatg tatcaggtat gcttccacgt aaaaaagcag 53220 gaagaaataa accttgggag atgcctcctg agttagaaca gctagttata aaatatgcat 53280 tgaaagaaat ataccaagta tggggtaact taatcattgg tgccggtatt gctaataaaa 53340 cattagaagt agacggtatt acagaaacaa taggaactac tcaatcagct atgtatggtg 53400 gagctagtgc tcagatactt caaataaatg aagatataaa agaattattg gatggtttaa 53460 gagcttactt tggatataat atgataggat tataaggagg gttagaaaat ggaaaaaccg 53520 tatatgatag gagccaactc taaccctaat attattaata agtcaacaac atatactact 53580 ataacacaag cagatgaaca agataaacct aagtatacta ctagactaga gtttgatact 53640 attgatatga ttaggtttat taatgaccga ggcataaaag tattatggga agaagcatat 53700 ttctgtccgt gccttaaccc tgactcagga catcctagag tagattgtcc tagatgtcat 53760 ggtaaaggta ttgcttattt acctcctaaa gagactataa tggcaataca gtctcaagag 53820 aaaggaacta accaattaga tataggtata ttagatacag gtactgcatt aggtacaact 53880 caattagaaa agagaatatc ctatagagat aggtttactg ttcctgaagt gttaatgcct 53940 caacaaatga tttattttgt aaataaagat agaattagaa aaggtatacc attatactat 54000 gatgtaaaag aagtaactta tatagccact caagacggta cagtctatga agaagattat 54060 gaaattaaga ataacagatt gtatttaaat gaaaaatatg agaaccatac agttacatta 54120 aagatactta tgactttaag atatgtagta tccgatatac taaaagaaag tcgttatcag 54180 tatactaagt ttaatcaacc taaatcaaaa tttgaaaact tacctcaaaa attacttctt 54240 aaaagggaag atgttattgt actacaagac ccttataaag ttaatgatgg tatagaagaa 54300 gacctagaaa ttcaagtaga tgaccctaaa gcttcggcat ctaatcctag taatttaggt 54360 ggattcttcg gaggtgcatt taactaatgc cggttcacgg aaagagacct aacttattta 54420 aaaataagaa ctataagcag gtaggtaaga gaaccattga tggtatgcgt tcagaagttc 54480 ttgacaagct acaagcaaca gcacagcaag tagagaatac tagtattaaa cgtatgccta 54540 cttatctaca agtaacagag aaaaaacttg aaaaagaagg cgtagtagac cttaaaaaag 54600 catttgctcg ttcatctaaa aagaaaacta gtaaagacgg aggatggtat ttaactgtac 54660 caatccgtat taaaactagt agaatgaata atagtaccta tcaagatatg agaaaattaa 54720 aagtaaatca agggacaggt tcagcttcta agataactga ttatctagaa gggcgtagaa 54780 agaatgtaag tcatccatca atgaaaccgg aacctatgac tcacaacatg actaaagtta 54840 aaagaggaaa gcaatcttct tactttatat ttagaactgt ttctagtaaa tcacctgcta 54900 gttcatggat acttaataga gataaagtta atgagaataa tttctctaaa acaactttaa 54960 aaactgttaa gcaactaatg aattggaaga tgaaaaattt aaattaaaag gagggttagt 55020 attaaatggc aataacatca gtcgattcat atttattatc agaaataaag cctagactta 55080 acactgtgct agagaattgt tatattatag atgaagtttt aaaagacttt gattatcaaa 55140 ctagagagag ctttaaagaa gctttctgtg gtaaaaatgc acaacatgaa gtaacggtag 55200 gattaactt cccaaaattt aaaaataact atgaagccca ttacttgata cagttaggtc 55260 aaggacaaga gacaaaaaac tctttaggga gtattcagtc atcttacttt gaggcaacag 55320 gagatacctt agtcgaatct tctacagcaa taagagaaga tgataagtta gtttttactg 55380 tttctaaacc tataggagag ttaataaaag tagaagatat tgaatttgca aaatttgata 55440 atcttaaagt agaaggtaat aaagtatcat tagatacca aactaatgaa gattatgaga 55500 attataatgc taacattatc tttactgaaa agaaaaatga ttcaaaaggt ttagtaaaag 55560 gattcacagt tgacgaacaa gtaacagttg taggtctatc ctttaatgta gacgttgcac 55620 gatgtttaga tgctgtatta aaaatgattt taatatctat gagagatagt atagaagagc 55680 aacaaacatt ccaattacag aatttgtctt ttggagatat tgcaccaata atagaagatg 55740 gtgactcaat gatttttggt agaccaacga ttattaagta cacaagttct ctagacttgg 55800 attatactat tacacaagat attaataaac taacttttaa agaaagaaag gattggaagt 55860 aggatggcta gaaaaaagac acctgaaaat aacactccta aatttaatgg ttatgttcat 55920 atagatacat tccttgatac tgcaaaaacc ctttttaata tgagggattc acaagtagca 55980 ggatttaaag cttatatgga aggtagtcat tatttgttta gtgagcaaga attcttaccc 56040 tcattagaga agtacttagg taggaaatta gatatataat aacattcaga taaggagaat 56100 taaatatggc agtagaacca ttcccaagaa gacctattac ccgccctcat gcatctattg 56160 aagtagatac ttcaggtatc ggtggctcag caggttcaag tgaaaaagta ttttgcttaa 56220 tcggttcagc agaaggcgga gaaccaaata cagtttatga attacgtaac tacgcacaag 56280 ctaaacgttt attccgttca ggagaattac ttgatgcaat tgaattagca tggggttcta 56340 accctaacta tacagcaggt aagattttag ctatgcgtac tgaagatgct aaacctgctt 56400 cagtagaagt tggcggatta aaagtaactt ctaaaatcta cggtaatgtt gctaataaca 56460 ttcaagtagg attggaaaaa aatacattaa gtgattcatt acgtttaaga gtaattttcc 56520 aagatgaccg tttcaatgaa gtttacgata atatcggtaa tatcttcaca attagatata 56580 caggtgaaga agctaacgca actttctctg tagaacatga tgaagaaact caaaaagcaa 56640 gtcgtttggt attaaaagta ggagaccaag aagttaaatc atatgactta actagcggtg 56700 cttatgacta tactaacgct attatcacag acattaatca attacctgat tttgaagcta 56760 agttatcacc tttcggagat aaaaacttag aatctaataa attagacaaa gcatcagatg 56820 taaatattaa agataaagct gtatacgtta aagcagtctt cggtgactta gaaaaacaaa 56880 cagcttataa tggtattgta tcttttgagc aacttaatgc agaaggagaa gtaccaagca 56940 atgtagaagt tgaagcagga gaagaatcag ctacagtaac tgctacttca cctattagaa 57000 ctatcgagcc tttcgaatta actaagttac aaggcggtac taacggtgaa ccacctgcta 57060 catgggcaga taaattagat aaatttgcac atgaaggcgg atactacatt gttccattat 57120 catctaaaca atcagttcat gcagaggtat ctgctttcgt taaagaacgt tcagatgcag 57180 gggaaccaat gagagctatt gttggtggag gattaatga atctaaagaa caattgttcg 57240 gtagacaagc atcattatct aatccacgtg tatcattagt agctaactca ggtacttttg 57300 ttatggatga tggacgtaaa aaccacgtac ctgcttatat ggtagctgta gcgttaggtg 57360 gtcttgcaag tggtttagaa atcggtgaat caattacttt caaaccatta cgtgtaagtg 57420 cgttagacca agtatatgag tcaattgatt tagatgaatt aaatgaaaat ggtattatta 57480 gtatcgagtt tgttcgtaac cgtactaata cattcttcag aatcgttgat gacgtaacta 57540 cattcaacga taagtcagac ccagttaaag ctgaaatggc tgtcggagaa gctaatgact 57600 tcttagtaag tgagcttaaa gttcaacttg aagaccaatt cattggtact cgtactatca 57660 atacaagtgc ttcaatcatt aaagacttta tccaatctta cttgggtcgt aagaaacgtg 57720 ataatgaaat tcaagacttc cctgctgaag acgtacaagt tattgttgaa ggtaacgaag 57780 caagaatttc aatgacagtt tacccaatca gaagcttcaa gaaaatctct gttagcttgg 57840 tttacaagca acaaacatta caagcctaat ctaggttatg gagtacctag attgggtact 57900 cctattaata taatttgaat actttaggag agtgaataca gatggcatca gaagctaaac 57960 aaaccgtcca tactggtaat accgtcctac ttatgattaa aggtaaaccg gtaggaagag 58020 cacaatcagc atcaggtact cgtgaatacg gtacaactgg tgtatacgaa atcggttcta 58080 tcatgcctca ggaacacgta tacttacgtt atgaaggtac aattacagta gaacgtttac 58140 gtatgaaaaa agaaaacttt gcagatttag gatatgcttc acttggtgaa gaaattctta 58200 agaaagatat cattgatatc ttagtagtag ataacttaac aaaacaagtt attatttcat 58260 atcatggttg tagtgctaat aactacaatg aaacttggca gaccaatgaa atagtgacag 58320 aggaaattga gaattttaca ctctgctcat agagtaatct gtgagtatta agggttaact 58380 gctatgaaac ttctaaagct caatcaacca cataggaatt ggaaacaata aactagaagg 58440 ttacgaaagt agaaaaaatg attgagatac tctaaggtta aatcctaagg agaagtacaa 58500 tgggtgtata gcatcgaata ctctaagtga tattaaatca taagaggaac gttcaacgac 58560 tatctcatta taagatgaga gtaaagctcc aagctattgg gagaagaaaa atccttgccc 58620 tactaattag ggataacaaa tagtctagtc acgtagtgaa agctagtgca tgtgaaataa 58680 cacaggttta caaagtagcg tttgtaaata aataaatcgt tttcgtactt gaccgcatca 58740 gataaagcca gaacataagt tcgtatttat tatagaatat agacctaaca ataaaagtta 58800 ggtcttttct attgacaaaa gactaatgat atagtatcat tagtatatac tttaatagaa 58860 gaggtgtttt aatatggaaa ttgaaaaatt agcaaaagaa aaaaatataa aaatcgtaga 58920 atatagaggt agagcaaaag atacaaaaca tttaggtgtt gttttggaag gtaaatttaa 58980 aggttgtgaa tgttacgtgt cctacaataa cttaaataac ttaaaacaaa taagactaac 59040 acaacttaca gaagaaggta aaaagaaata tttttcttct tacgctaaaa gtagagggta 59100 tagtattata aactaccctg aaaatctgca atcaacaaag agatgtttac tactatcacc 59160 gcaagggaat aaatgggatg ttatatggaa tagttttgag aacaatacta ataataataa 59220 ttgtcctcaa gaccatatga aaagtatcgg agagagaatt atacagacta tacttaaaga 59280 aaatggtatc gaatttatat gtgaaaaatc tatctacaca ggattagaga gaccacaaag 59340 attagatttt tatatagaat taaatggtaa taaatatgct attgaatata tggggcaaca 59400 acatattaaa caagctactg gaacatggag tacgccctta gaaaagatac aagagctaga 59460 ttcactaaaa gaaaaatact gtaaagataa taacataaag ttactatata tctattatcc 59520 taatgaagac aaaaaggaca tattaaatac tataagttcg ttcttagaaa ttaatttaaa 59580 ttatactgag agaatagaac tgtttacaaa atataaagaa aatgaaaaag agattataga 59640 attctataaa gaacactctt cagaagaaac tgcaaataaa tttaatatga gtgttggtaa 59700 tgttaaaggt ttaatgaaac gtagaggggt taagaaaaga tttaaacctg tagtaggatt 59760 aaatattaag acactagaag aaattagatt tgatacttta aaagaagcac aggaatattt 59820 tagtaattta ggattacctt catcaagtat tagagggtgt gtatcaggaa gtaaaaagca 59880 atcatgtggt tatctttgga gatatgaaga tgaagacttt tcagaagtag ctaaaacaat 59940 aacagacaaa agaattaaag tatatgtagc aactaaaggt tcagaagata ttaagttgcc 60000 tttgcatatg atgacaaaaa gaataagttc agatgtagca tccattgtag attgtgctaa 60060 aggtaaaaga aacactgtta aagggtacaa tattagagaa gctacagaac aggaaaaaag 60120 tgatacacta aaaagtataa gctatattga ctatatacaa aattataaat aacctttgac 60180 caataccaag ggttatgtta ttataataaa taaggaggga ttaacttgac aaatagaaaa 60240 acaataggta aaatgagtaa tacaagggca acatggaata ttaaccctgt aactaaagtt 60300 aagaaagata aaactaaata ttctagaaaa aataaacata aaggtcttga caattataat 60360 tagatacagt atactaagat tataacaaat aaggagatgg attatatgag tacattttgg 60420 tcaaaaagaa gaacaaccgg taaagacagg caagtaaaga aacattatac tcaaatgtct 60480 ttacaagaaa agaagcagtg tgttaaacta ttacaagata caattaatac acataaatat 60540 ttagaactat caaaccattg caaaactaaa attaaaaatg aaatcaattt tagtaagtta 60600 gtaggattta tattaaaag taataatgca ccttttaata ttattgaatt taatattaca 60660 gattttcatg gtaaaaagca aagaaggatt atttttaaaa gtcctactat tgtaactata 60720 gaaggagtaa gtagttatca gtacttagtt attaacctgg aagatggtaa aataataact 60780 acatactata atggcattac agatacacac aaaacattag atttaaatta ttatgataaa 60840 ggcttgacaa ttaaataagg aggaattata atgggattga caatagtaaa tagttacttt 60900 atcctatcaa gtattatatt tattgtatta agtatattaa atggtaaggg tacagttaca 60960 gaggaatcac tagctatgag taaagcatta gtggtaataa catcagttca atttttagca 61020 tgtttaatta ttaatggtgt ttattactca ttaaaatata tgtaaaaaaa gtattgacaa 61080 attaaaaata ataaattata ataaagatat aacaaattaa aggagaagat ataaaatggc 61140 acaagataaa ttaagagcag tttatgaaga gatgaaagta gaattacaaa aattcccaca 61200 agaggtagat gtaacaagta aatcaacagc aattgcaatc aatcagattt tagataaatt 61260 caaaacatta actgagcaag caggaaagat tactaagaaa tatatagaag gtcaagaaat 61320 attaactatt gattatgagt attatgattc attacaagaa tactacattt atttaactaag 61380 aaatagtgat aaaattaaac aaagtttaga ggaaatttta acaagcacag agaaatactt 61440 aaagtaattt tgatttaaaa acaaaatatg atatactata tttaaagtag taagcctaca 61500 ctagtccgtg ttatattaat attgaatcgg ataagcgtag gctttattaa tatttaaaaa 61560 aggaaggtat atcatattat ggcagaagaa attaaaaagg aacaagaagt acaagaaaca 61620 aaagaagaga aaaaggatgt cagtaaaatg acaccggaag aaatagataa attaaaatac 61680 caagacaagc aagaaaaaga aaaagttatt aacaaagtta ttaaaggtgt taatgacaca 61740 tgggaaaaag agtataactt tgaagaatta gacttacaat ttaaagttaa aattaaattg 61800 cctaatgcac gtgaacaagg taatatcttt gcgttacgtt ctgcttactt aggtggtatg 61860 gatatgtatc aaacagacca agtaattaga gcttatcaaa tgttagctac attacaagaa 61920 gtaggtattg aagttcctaa ggaattccaa gaccctgagg atatctataa cttatatcct 61980 ttaactgtta tgtatgaaga ttggttaggg ttcctaaact cctttcgtta ctaatagtat 62040 agaaacacta gataaagata tagaacgatt gggtggtatg gaatcaattg ttaaacaacc 62100 tttatctagg aatctatggg ctattatgaa agagtttaat gttttaccta ctgagcaaag 62160 atttaaggac ttagatgact atcaaataga gtttattatt ggtaatatga acagagatgt 62220 ttatgagcat aataaacaaa ttaaacaagc tcaaaaaggt ggcaagtacg atagtcaatt 62280 cgaagatgat gatagtagtt ggtggaatga atctcatgaa gactttgacc cagtacctga 62340 tttcttagat gctgatgact tagcacaaca gatggaagct aaattatctg acagagataa 62400 ggaagaaaga gctaagagaa atgatgcaga gttgaatgat gagacagaag gactcactac 62460 acaacatctt gctatgatgg aatacattag aagaaaacaa gaagaattag atgatgaagt 62520 aggaaacggt aaaactagtg aagatgatgc tactatatca caagagagcg ttaataaagc 62580 actagaagac ctagatgatg attggtatat gtaaagggtg gtaggtgata ctaccatcct 62640 tattttttta aaatggatgg tgagtaatga tggcaatgaa tgacgattat agattggtct 62700 tatccggtga tagttcggat ttagagaata gtctgaaggc tatagaactt tatatggact 62760 ctttagaggc taaaaatatt gatgcccctt tagataattt cttaaagaaa ttaaaagtaa 62820 ttgctaaaga agttaagaat gtacagaatg caatggataa acaggaaggt aaatctgtag 62880 tatctgctaa agatatggat gagaccatta aatctactca atctgctacg aaacaaataa 62940 atgagttgca gaaagcttta gatgaccttc aaaaagaaaa tatatctaaa ggtatagcac 63000 ctgaccctga agttgaaaaa gcatacgcta agatgaataa agttgttaat gagactagtg 63060 aaaatcttag taaaatgtct aaccaaaaaa taggctcaga tgcaagtatt caaaatagaa 63120 ttaaagaaca gaaaacctta aataaagtaa cagaagaata taataaaatt agtaaagatt 63180 ctagtgctac tcaagattat acaaaacgtt taagagctaa ccgtaatatg actagaggtt 63240 acagggaacg ttcagaagga acaggacgtt taacatatga ccaaggggca cgagttagaa 63300 gtgaactagg taaggtagat tcttatgaaa gtcaaagaaa acaaaaccaa cgtaatttaa 63360 gccaagcaag agaacaatat agtaattacg gtaaacaaca acaagacctg actaaccgta 63420 gagctagtgg tcaaattaat aaagctcagt atgaaaaaga gctagcttct attaaaatgg 63480 aaatgaaagc tagagaagaa cttatatcta actatgaaaa attaggagca gagcttgata 63540 aaactgttca atattatagg ggttcagtac aacaagattt tcaaactaga agagtagacc 63600 aacaacgagg gacattcggc agaatgattg aggagcgttt accatctatc ggttctcacg 63660 caggtatggc tatgacaggg gctatgacag gtctatacat gaaaggtgct tctctaagtg 63720 aatcaaatag accaatggtt acatcattag gtcaaaattc agataatatg gatatagatt 63780 ctgtaagaaa tgcatatggg gacttgtcaa ttgataacaa attaggttat aatagtaatg 63840 acatgttgaa aatggctact tcatatgaat catcaatagg acataaaagt gatgaggata 63900 caatggcagg agctaaacaa cttgctatcg ggggacgttc attaggaata caagaccaag 63960 aaatgtacca agaatctatg aatcaactaa tgcatactgg tggagtaaat tccaataaca 64020 tgaaggaaat gcaagatgca ttcctaggtg gtattaaaca atcagacctg attggtcgtc 64080 aagatgaaca acttaaagca ttaggttcta tagctgagca atcaggagaa ggtcgaacat 64140 taactaaaga ccaaatgggt aatcttacag ctatgcaagc aacttttgca gaatcaggta 64200 gtaaaggttt acaaggtgaa cagggtgcta acgctatcaa tagtattgac caaggactta 64260 aaaatggtat gaatagttct tatgctcgta tagcaatggg atggggaaca cagtaccaaa 64320 gtcttgaagg tgggtatgac ttacaaaaac gtatggatga aggtatatct aatcctgaaa 64380 acttgactga catggttgat atggctactc aaatgggtgg tagtgaaaaa gaacaaaaat 64440 atttatttaa cagaagtatg aaagagttag gctctaacct tactatggag caatctgatg 64500 agatattaa agatgctcaa tcaggaaaac tatctaaaga agagttatct aaaaaaatta 64560 agaaaatgga aaaagaaggt agtaaagaag gagaagataa tagaaccgat tatgaagagt 64620 ctaagtcagg tagaaatgac caaaacaaag ctaaaacaga tgataaagca gaggatattt 64680 atgatttagc tcaacctgta agagatgttc atagtgcctt tgcaggtctt ccggcaattg 64740 tatacgccgg agccactgct gtaggggtat tcacggcttc tttacttgca tctgcaggac 64800 aatttggttt gggtcgtgta gtaggtaaag gtaaacaatg gatagataag aaaagaaatg 64860 gtggtaaatc aggaggagga acaccgcctc caggaacaag cccaggtaga caaaaatacg 64920 ctaataataa tcctaaaaca cctaatggcg gaggaacttc aggaggttct agagtaggta 64980 gtatgtttga aaaagctaag agctttggag gaaaagctct tgccggaggt atgttatttg 65040 gtgataaatt attaggtggt aaaaataaaa aaggcggaac tcgttccgga aaagaacagt 65100 ttaaaggtac ttgggatagt actaagaaaa ctggtaaagg gttatttgac cacttaaatc 65160 ctaagaaccg agactttact atgggagatt acttaggtag aacaaaagat ttaggtaaaa 65220 aaacaggtaa aggtataaaa ggttttggta aggagacatt tagtgggagt atactacatc 65280 ctaagaattt taaaggctta ggagataaaa ctaaaggtct tggaggcaaa ataaaatccg 65340 gaacaggtag tttacttaat aaaggtaaag gtgcttatgg taaatttgct gataagtttg 65400 gtgatggaag taaaaatggt attatgtcac aatcaccaaa agcaggtgga atagataaaa 65460 ctttaggtaa aggaaaagac ttagctaaaa aaggtttagg tgcaatgcct aaaggtgtag 65520 gggcatttgg taaaggtgca ggtaaattag tttctaaatt cgtacctgga cttaatatag 65580 gtttatcagc tcttaacttt ggtagcagga tgaagaatgg tgaaggtgta ggggaagcct 65640 tatctaacac agcaggtgac tttatagacc catttggatt aggttatggt gaaaaagtcg 65700 gagatatggc taagaaagct gagaccaaag agggatggaa cctaggatgg tctaatggag 65760 acaaagatgg taagaataaa ttccaagatt ctgtaatagg aaaacctata tctaaagcat 65820 ggagtggtat aacaggactc tttgacaatg aagctgaagc atctgaagaa gatagtaaag 65880 atagtaaaaa aggcgttaaa ggtgttaaaa aagataataa gaaaaaagaa aaaatgacag 65940 cagaacaact tagagaaaag aataatcaat ctgaaactaa gaaccttaaa atctatagtg 66000 atttacttga tagagctcaa aagattattg agagtgctaa aggtattaat atagacggag 66060 gaacatctga aggtggttct gacggaggct ctgcatctga tgtaggtgga gaaggtgcag 66120 agaagatgta taagttcctt aaaggaaaag gactatctga caatcaggta ggggctgtca 66180 tggggaactt acaacaagaa tctaatcttg accctaatgc taagaatgct tctagcgggg 66240 cattcggtat tgctcagtgg ttaggggata gaaaaacagg attagaaaac tttgctaaat 66300 ctcaaggtaa gaaatctaat gatttagatg ttcaactaga ctacttatgg aaagaaatgc 66360 aatctgatta cgaaagtaaa aatcttaaga atgcaggttg gagtaaagat ggaagtttag 66420 aacagaatac aaaagcattt gctaccggat ttgaacgtat gggagcaaat gaagctatga 66480 tgggtactcg tgttaataat gctaaggaat tcaagaagaa atacggaggt tccggtggag 66540 gaggcggtgg aggtgcctta tcctccacat accaagaagc tatgagtaat ccagtattaa 66600 ctactggttc taactacacg ggctctaatg atgcttctaa tgcttctaca acgaatcgaa 66660 taacagttaa tgttaacgtt caaggtggaa ataatcctga agaaactgga gacattatcg 66720 gcggaagaat tagagaagtg ctagatagta atatggatat ctttgcaaat gaacataaga 66780 gaagttatta gtaattttgt cttgacacaa gagtagtatc atagtatact actcttatac 66840 atataaaaaa ataaaaggaa gtatgtgtat atgcgtagaa taagaagacc taaggtaaga 66900 atagaaattg ttacagatga taatacattt acattaagat tcgaagatac acgagattat 66960 aatggtgatg aatttggggc taaactatta ggatttcaaa ctaaaaactc tatggaagac 67020 gatagttcag ttttccaaat caatatggca ggagatactt attgggataa gctagttatg 67080 gctaatgata ttataagaat atttattact cctaatgatg accctaacga taaagaagga 67140 agacaagaac gactcattca agtaggtatg gtttcccaag tatcaaaagt aggtagttat 67200 ggtaatgacc aaactcagtt tagaataaca ggtcaatctt ttgtaaaacc atttatgaaa 67260 tttggattag gtgttattca agaggttcaa gctgtattac ctgaagtcgg ttggcttatt 67320 gatggtgatg gagataatga agtaaaattt actggtagct cagcccatga ggtaatgaca 67380 ggaattatac gtagattcat accgtatatg aaatataact acactgaaaa aacatataat 67440 acaatagata gctatcttga ttatgatgat ttaagtagtt gggatgagtt tgagaaactt 67500 acagaagttt ctgcgtttac taattttgat gggtcattaa aacagttaat ggatatggtt 67560 acagctagac cttttaatga attgttcttt aaaaactctg aaaaaacacc aggtaaagca 67620 caacttgtat taagaaaaac accttttaat cctactgagt ggagagcttt ggatatgatt 67680 aaagtaccta ccgaagactt cattgaggag gatgtaggta aaagtgatgt agagacatat 67740 tctatattta cagctacacc tgcaggtatg ttaaaagaac ttaatggtga tgtattctct 67800 aaaccacaat ttcatcctga attgactgat agatatggat atactaaatt tgaagtagag 67860 aatatctatc ttagtaccac atcaggctca gctacagaag attcagattc aacaggagat 67920 gacaacggag cagaacgagg tacgtattcc aaaatcatga aagacttaag taactatggt 67980 agagataatg tttctaaagg tatagacaaa tatacaagta agttatcagc taaatataat 68040 aatctaaaga aagcacaagc taaaaagatt atagagaagt atgttaaaga aggaaaagta 68100 acagaaaaag aatatgagaa aataacaggc aataaagtag aagatgaatt aacatcagat 68160 aacagaccga agttgacaaa gagtaaatta aagagtatac taaaagagaa gtttaaaaca 68220 caagatgatt ttaataattc caagaaaaag aaaaaggcta aaaaagatgc acttaaagaa 68280 ttgacaacta aatatcgttt tggtaataaa acacacgcta caactttgct agatgaatat 68340 attaaataca aaggagaacc acctaatgat gaggcttttg ataaatacct taaagctata 68400 gaaggcgtga gtaatatagc tactgatacg ggctcagatg caagtgatag tcctttagct 68460 atgttctcta gaatgttatt taattggtac catggtaacc ctaacttcta cgcaggtgat 68520 attattgttc taggtgaccc taaatatgat ttaggtaaaa gattatttat tgaggataag 68580 caacgaggag acacttggga attttatata gaatctgtag aacataagtt tgattataaa 68640 cagggttact atacaactgt aggagtaact agaggtttaa aagatgctat cctagaagat 68700 ggtaaaggaa gccctcatag atttgcagga ttatggaacc aatcatcaga cttcatggga 68760 ggtctcatgg gagaagatac atccaaagag cttaaagaaa aaggagtatc agagaaggaa 68820 agtagcggag ataaagatgg aggctctgat agtggaggag ctcaagatgg aggttcacta 68880 gcttcactta aaaagtttaa cggtaaactt cctaagcatg acgctagctt tgttcagccc 68940 ggtaaccgac actacaagta tcaatgtaca tggtatgctt acaacagaag gggtcaatta 69000 ggcattcctg tgcctttatg gggggatgcc gccgactgga ttggcggtgc taaaggagca 69060 ggttatggcg taggtaaaac ccctaaacaa ggtgcctgtg ttatttggca acgaggagac 69120 aaaggcggtt ctaatgctta tggtcacgtt gcctttgttg aaaaagtttt agatggtggg 69180 aagaaaatat tcatttccga gcataactgg gctacgccta atggctatgg tactagaaca 69240 atagatatga gctctcaaat aggtaaagaa gctcaattca tttacgataa gaaataaagg 69300 aggatagttt atggcaacag ataaagaagc taaagatgtt attgataagt ttatagataa 69360 tgtgtttaat tttgatgtac taactacgga aagagttaaa gaaaaagatg aagaaattaa 69420 aaaaatcact acagaagata tgtatgagaa ggttgtttat atacgacctt acgttggggt 69480 aatccaaagc ctaaaccctc aacatgtgca atatgaatca ttttctaata atgggtatga 69540 tgtagaagca gaattaagtt ttaggaaagt aagttatcta acagataaag ggtctatacc 69600 tacagattct ttatctactt taacagttca tttagtagaa agaaatcaag aattactaat 69660 agattatttt gatgagattc aagatatact atatggagaa tatatggaag aagaatatat 69720 atttgatgag gatgtaccat taagtacgat aatagcatta gacctaaatg ataatcttaa 69780 atccttatca aatataaagt atatgttcaa aggtgctcct aaagagaatc cttttggaac 69840 agataaagat gtttatatag atacttataa tttattatat tggttgtatt taggtgaaga 69900 tgaagagtta gcttacccta tgaatattaa ctatttcttt acagaaggaa gattttttac 69960 tattttcggt aaaggacata agtataaagt agatgttaat aaatttatag ttggagatat 70020 attattcttt ggtagaagtg atactaatat aggtatttat gtgggtgacg gagagtttat 70080 atctatgata ggtaaattcc ctaaagatga aacatctata gggaaatata aacttgatga 70140 ttattggaat gaatttaacg gaagagttat gagattcgat gaagaggagt atatttaatg 70200 gtagtaagat tccaatcttc catgggaaga agtttaaaaa gagtagattc agatgattta 70260 aatgtaaaag ggttagtttt agctacagtt agtaaaatta actataaata ccaatcagta 70320 gaagttaaag ttaataattt gactttagga agccatatag gtgatgacgg tagcttagct 70380 gtaccttatc ctaaatcttt cataggtaga acacctgaag gaagtgtatt cggtacaaaa 70440 ccgcttatta ctgaaggctc tgtagtatta ataggatttt taaatgatga tataaacagt 70500 cctatcattt taagtgtata tggtgataat gagcaaaacc aaatgattaa tactaacccc 70560 ctagacggag gtaaatttga tacggatagt gtttacaaat atagtagtgc actatatgag 70620 atactcccat ccttaaatta taagtatgag gatggtgaag gaacaagtat taaaactttt 70680 aatggtaagt cattcttctc tatgacatca ggagaagaag agaaacctca agcaacagat 70740 ttctatacag gaacagagta tcaagattta tttacttctt attatggtaa taagacatta 70800 attgagccta gaatacaaaa ggctcctaac atgttattca aacatcaagg agtgttttat 70860 gatgacggta caccggataa tcacataact actctattta tatctgaaag aggggatata 70920 agggcttcag ttctaaatac agaaacacag aagagaacta cacaagaaat gtcaagtgat 70980 ggttcatata gagtcgttaa acaagatgat gacctaatgc tagatgaagc tcaagtatgg 71040 attgaatacg gtattagtga agataataaa ttctatatta aaaatgataa gcataaattt 71100 gaatttactg atgaaggtat ctatatagat gataaaccta tgctagaaaa cttaggtgaa 71160 agtataacag aggctatgaa gaatctaaat gaaatacaaa aagaactaga tgatataaac 71220 tatcttcttg agggtgtagg taaggataat ttagaagaat taatagaatc tacaaaagaa 71280 tctattgaag catcaaataa agcaacttca gatgttaata gacttacaac tcagatatca 71340 gaggttagcg gtagaactga gggtattata actcaatttc aaaaatttag agatgagact 71400 tttaaagatt tttatgatga tgtttctcct gttataactg aagtaaatca gaatttccct 71460 agtatgaaaa cagatgttaa taacctaaaa actaaagtta ataacctaga aaaaactgag 71520 atacccaata tcaaaactag actaacagaa ctagaggata ataataacaa tgcagataaa 71580 ataatttcag atagaggaga gcatataggt gctatgatac agttagagga gaatgttact 71640 gtacctgcaa gaaaatatat gacaatacct tggagtaaag ttacttataa taatgcagag 71700 ttttgggatt ctaataatcc tactagatta gtagtaccta aagggataac aaaagtaaga 71760 gtttcaggta atgctttgtg ggattctaac cctacaggac aacgtatgtt gagactattg 71820 aaaaacggta cttatagtat aggattgcct tatacaagag atgtagctat atctacagca 71880 cctcagaacg gtgctagtgg agttattcct gttaaagaag gagactattt tgagtttgaa 71940 gttatacaag actcagaagg ggatagacaa ttcagagcag accctttatac atggtttagt 72000 attgaagcta tagaattaga aactgaaacc atggagaaag acttcatgct tataggtcat 72060 agaggggcaa ccggatatac agatgagcat acaataaaag gatatcaaat ggctttagat 72120 aaaggtgcag attatataga gttagattta caattgacaa aagataacaa gctattgtgt 72180 atgcatgatt ctactatcga cagaacaaca acaggaacag gtaaagtagg ggatatgact 72240 ttatcttata tacaaactaa ctttacatct cttaacggag aaccgatacc atctttagat 72300 gatgtattaa atcattttgg aacagaagtt aaatactata tagaaactaa acgtccattt 72360 gatgctaata tggataaaga gttattaacc caattaaaag caaaaggact aatagggata 72420 ggttcagaga gattccaagt aatcatacaa tcgtttgcta gagaatcatt aatcaatatt 72480 cataatcaat tctctaatat acctttagct tatttaacaa gcacattctc agaagcagaa 72540 atggatgatt gtttaagtta tggttcttat gctattgctc ctaagtatac aactataact 72600 aaggagttag tagacttagc acatagtaaa ggacttaaag tacatgcatg gactgtaaat 72660 acaacagatg aaatgcaaag cttaatacag atgggtgtag atggattctt tacaaactac 72720 ctagatgaat ataaaaatat ttaatattaa agacctatta atttaggtct ttttttagtt 72780 gtaatttaaa ctagttcgtg atatattagt agtatgagat ttatatacat actgaaaagg 72840 agaggataaa atgccacaat cagacggaat aagtagcctt catagaatag ccttacgttt 72900 ccctaaagag ggcggtggtt atgatatgta tagatttaaa gttaaccctg agaattacac 72960 aatagatgca ccacaacgta caacagcaat taaaacaaaa tcggatattg tagtagaaga 73020 ttatggtaaa gacatagaag ttattaactt ctcaggtact actggattta gaccagttag 73080 agaggtagat ggattaaaaa caggtaaaca gaaaatggat gagttacaga aaagggttac 73140 tgactatgct acccaaggag gtaacggtaa tgtaagtggt tcctacttac aattctttaa 73200 cttcacagat ggtaagtatt ataaagtaca tctagcaccg caagggctta aaataactag 73260 gtctaaagat gaaccgttac tttttagata tgaaataaca ttagtagtta ttggttcact 73320 aacagaagca gatagaagtg ctgtaacaac agaagagttt ggtaatgtta atcctaacgc 73380 ttctcaaaga gtagatgaag gtctaaaaga gttagataaa aatgctcgta aaacgaaga 73440 tagaaataac caagaaatat ctagaagaga aaatacaata cctaaatcta caggagataa 73500 tacaaacgag agtaacagat tgaagcaaag tttccctagt agctctatat ataatcctag 73560 acaatctact aatggattaa aaggaaacat tgataacatg gctttaataa taggttatgg 73620 tgatggaggt gtatctagtt aatgaataat tttatagcac aaccacaagg tttacttaga 73680 tttttaaatg ctttagacac agacttaact tattctcaca tgaatttact tgatgaagag 73740 atatcatttg tatctaaatt ttatacacca caactacaat taagtgaatt agcaaaaaaa 73800 gtattgacaa atctaaagac agatgatata cctgtattag aaagagaatt taacgataat 73860 acaattattc ataaagctaa taatacatca ctaaaagtcc aagcacctag aatgtatatg 73920 attctacaat ctattgtcct tgaagcatat gctattgtta attgctttgt agagaatcca 73980 agttctttaa aatatttaac tgaagaagat attaatataa cacgagaaaa cttgaattat 74040 gtagcagatt acttaggtaa ctatgatgac tataatagtg ttgttttaga tttaagagag 74100 ttagatttat gttttagtgc aatagaatta caactacctc taattaaaaa ggaggctaac 74160 gtataatgag atttaagaaa catgtagttc agtatgaaga aacaatgcaa gcaatagcac 74220 aaagatatta cggggatgtt agttactgga tagacttagt agagcataat aacttaaagt 74280 acccttacct agtagaaact gatgaagaga aaatgcaaga ccctgaaagg ttagcttcta 74340 caggagatac aattattata cctatagaat ctgatttaac agatgtatca gcaaaagaga 74400 ttaattctag agacaaagat gtattagttg aattagcttt aggaagagat ttaaatatta 74460 ctgcagatga aaagtatttt aatgagcatg gtactagtga taatatacta gcatttagta 74520 caaatggtaa tggggattta gatactgtaa aaggtataga caatatgaag caacaattac 74580 aggcacggtt attaactcct agaggttctt taatgcttca ccctaactat ggttcggatt 74640 tgcataattt atttggtctt aatatacctg aacaagctac attaattgaa atggaagtat 74700 tgagaacatt aacatcagat aatagagtaa aatcagctaa cttagttgat tggaaaatac 74760 aaggtaatgt ttattcagga caattctcag tggagataaa atctgttgaa gaatcaataa 74820 attttgtttt aggacaagat gaggaaggaa tttttgcttt atttgaatag gaaaggatta 74880 aattatgaaa actagaaaat taactaacat actatcaaaa ttaatagata agacaatgac 74940 aggtacaagt aagataacag attttacccc tgggtcagct tctcgttcat tattagaagc 75000 tgtatcatta gagatagagc aattttatat cttaacaaaa gaaaatattg attggggtat 75060 acaagagggt attattgaag cctttgattt ccaaaagaga caatctaaaa gagcttatgg 75120 tgatgtcact attcaatttt atcagccttt agatatgaga atgtatatac ctgcaggaac 75180 aacttttact tcaacacgac aagagtatcc gcaacagttt gaaacattag ttgattatta 75240 tgcagaacct gactctactg agattgttgt tgaagtttat tgtaaagaaa caggagttgc 75300 gggtaatgtt cctgaaggaa caattaacac tatagcatca ggttctagtt tgattagaag 75360 tgttaataat gagtattctt ttaatacagg aactaaagaa gagagtcaag aagactttaa 75420 gcgtagattt cactcttttg tagaatctag aggaagagca actaataaat cagtgagata 75480 cggagcatta caaatacctg atgtagaagg tgtttatgtt tatgaagaaa caggacacat 75540 aacagtgttt gctcatgata gaaacggtaa tttatcaaat actttaagag aagatataat 75600 tagtgcttta caagactata gaccaagtgg tataatgtta gatgttacag gggtagaaaa 75660 agaggaagtc aatgtttctg ctacagtaac gatatctaat aaatctagaa ttggtgatac 75720 attacaaaaa catattgaag gtgttattag aagctattta aataatttaa aaacttctga 75780 tgacctaata attacagacc ttattcaagc tgtaatgaat attgatgatg tattaatcta 75840 tgatgtgtca tttgataact tagatgaaaa tattatagta ccaccacaag gaattattag 75900 agcaggagaa ataaaagtag aactaatgta aagagaggtg aaaattaagt cgtggctaat 75960 tttttaaaga atcttcatcc attattaaga agagatagaa ataaaaaaga taatcaagac 76020 cctaactttg ctctaataga ggcactcaat gaagagatga atcaagtaga gaaagatgct 76080 atagaaagta agttacagtc atcacttaaa acagcaacaa gtgaatactt agataagttt 76140 ggagactggt tcggtgtcta tagaagaaca aatgaagatg atacagcata tagagcaaga 76200 attataaaat acttactctt gaaaagaggt acaaataact ctataataga agctataaaa 76260 gattatctag gtagagatga tattgatgta agtgtgtatg aaccttttac aaatatcttc 76320 tatacgaaca aatcacattt aaatggtgaa gaccatttaa tgggttatta ctatagattt 76380 gctgttatta atgtctctat aggtgattat ttccctatag aggttgtaga tgtaattaat 76440 gaattcaaac ctgcaggtgt aacattatat gtcacttatg acggagcctc tactattaga 76500 gggggagcaa ttattaagtg gctagaaggt ctacctaaaa ttgaaacata ccaagagttt 76560 gatagattta taggttatga tgacacattt tatggtcatc ttaatatgaa tcaaagtaaa 76620 gataatgata atagttcatc agacattttt aaaacaaatc atagcttaat taatagctta 76680 gatgttttaa ccggttcctc tagtgtaggt agacagtatg ttaactatgg gtatataaca 76740 tcatatgttt ataatccaag tatgacatct tctgtaaatc aaataagttc tagtacagaa 76800 gatagagggc aagaagtacc tactgactac tatatgtata ctagtattaa gaataacaat 76860 acagtagaac taaacatgca aactagttcc ggtgtgtctt atttatataa taactttaat 76920 tttagagatt atatgagtaa atatagacct gaagtagact tacaatctga tgagtctaga 76980 agaattgtat ccaattatgt aaaagaatta agtattgatt actaccttag tgctgtaata 77040 cctcctgatg agagtataga aattaaacta caagtttatg acttctctat taatagatgg 77100 cttacagtat caattaataa cttgtctttc tatgaaaaaa atattggtag taatataggt 77160 tatataaaag attacttaaa tagtgaatta aatatgttta ctagattaga gataaatgca 77220 ggtagaaaag gttcagtaga tattaaagtt aactacttgg atttaatgtt ttattactat 77280 gaacgaggta tctacacaat aaaaccttat aaagcattag tagaaaatta cgtagatatg 77340 tctagagata ctaacgtaga agcatttaaa gtaacatcgt tatctaatgg agatatcata 77400 actaaaacag gtttccaacc tataagatac cttaaattaa ctgctactta ttctactgaa 77460 cccactacat taactttaac cggaagcaca tctagtaatt attcttacag ttctatagat 77520 atttcggaat cattaccagt taagtctaat atcatagaaa gagagcttgt atataatgat 77580 ataaaaactg atttacagtc tattataata aattccaacc aaccactaac aaatgttcaa 77640 ttaagttact cctattatgg tgatagttgg gttgttttaa aagaaataga taatttaacg 77700 gaaggaacaa ccactatatc aaataactta atagatttgt atggattgca aacagtagat 77760 tattctaata taaatccaat gtcagaagta tcattacgtt ctatttggaa tgttaaatta 77820 ggtgaactta ataatataga aggttcttta tctaatatgt ctaatgatta ttttaatgct 77880 gtatggcaag atatagataa actatcagat attgatttag gttctatgag aatagttaaa 77940 gacactgaag gtggcgtatt tgatggagct acaggtgaag ttattaaagc tactatattt 78000 aacgttggtg tttatactga tttagacatg ctatcttata ctctaaataa ctatactgag 78060 ccattgactt tagggtctag tagactaata agtgagctta aagatgagtt attaacaaca 78120 gaatcactta atatagataa cagaattaaa gtaatataca ctgatacaga aattacaatt 78180 aatgaataaa taagttgaca ggaagttaat aatatggtat acttataaag taatatttag 78240 tgggtatacc atgttatatt aataaagaaa acaacagatg aaaggaatta aaaactatgg 78300 caattgcaac gtataattct catgttgagt tagcaaaata tatagttagt aaagctgact 78360 cagtttactt aacaattgga aagagcacac cgtggtctaa tgaaacaaat ccaccacaac 78420 ctgatgaaaa tgcaacagta ttacaggagg ttattggata taaaaaagct actaaagtta 78480 ctttagttag acctgctaaa tcacctgaag atgataataa gaatttaatt tcttatggta 78540 ataaatcatg ggtagaagta acacctgaag atgctaagtc agaaggagct aagtgggttt 78600 acttagaaag tagtattgtt ggagacgaac tacctcttgg aacatataga caagtagggt 78660 ttgttatgga cttagtagca aaaagtggta ttagtaaatt taacttagta ccgagtgaag 78720 tagaatcagt tggaacatta ttattctttg acaataaaca gttccaaaat agaagtgagc 78780 agacaactgc taaagaaaga tttattgtag aagtttaaag aaagggagat aattctaaat 78840 ggcaattaat tttaaaggtt caccttattt agatagattt gacccgtcta aagatagaac 78900 aaaagtatta tttaatcctg atagacctct acaacaggca gaattaaatg aaatgcagtc 78960 tatagaccaa tattatttaa aaaatctagg agacgctatt tttaaagacg gagataaaca 79020 atcaggactt ggattcacat tgactgaaga taatgtattg acaataaacc ctggttatgt 79080 atatattaat ggtaaaataa gatattacga tagtgatgat tcagttaaaa taactggagt 79140 aggtaaagaa actatcggta tccagttaac agaacgcatc ataacacctg atgaagatgc 79200 tagtctatta gaccaaacta gtggagtacc aagttacttc tctaaaggtg cagatagatt 79260 agaagaaaag atgtcattaa cagttaatga ccctacctca gcaactatat atactttcat 79320 ggatggagat ttatatatcc aatcaactaa tgctgaaatg gataaaatca ataaagtatt 79380 agctgagcgt acttatgatg aatcaggttc atataaagta agtggctttg agttattctc 79440 agaaggtaat gctgaagatg atgaccacgt ttctgtagtt gtagatgcag gtaaagcgta 79500 tgtaaaaggt tttaaagtag ataaaccagt atctacaaga attagtatac ctaaatcata 79560 tgacttagga acagcagaga atgaaagtac agttttcaat aaatctaata actctattag 79620 tttagctaat agtcctgtaa aagaaataaa acgtgttaca ggtcaagttc ttattgaaaa 79680 agaacgagtt actagaggag gacaaggtga cggtcaagac ttcctttcaa ataacacagc 79740 atttgaaatt gtaaaagttt ggactgaaac aagtcctgga gttactacaa aagagtataa 79800 acaaggagaa gactttagat taacagacgg tcaaacaatt gactggtcac ctcaaggtca 79860 agaaccttca ggaggtactt catactatgt ttcttataaa tacaataaac gtatggaagc 79920 tggtaaagac tatgaagtaa caactcaagg tgaagggtta ggtaagaaat ggtacgttaa 79980 ctttacacct tcaaaagggg ctaaacctat tgaccaaaca gtagtattag tagactacac 80040 ttactactta gctcgtaaag attcagtgtt tattaataga tacggtgata ttgcaatatt 80100 acctggtgaa cctaacatta tgagattagt tacaccacca ttaaatacag accctgagaa 80160 tttacaatta ggtacagtta cagtattacc ggactcagat gaagcaattt gtatttcatt 80220 tgcaattact agattatcta tggaagactt gcagaaagtt aaaacaagag tagataactt 80280 agagtataac caagcagtaa atgctttaga tgatggtgct atggaaggac agaacccatt 80340 aacattacgt tcagtgttta gtgaaggttt cattagtctt gataaagcag atattactca 80400 tcctgacttc ggtgttgtat tcagttttga agatgcagaa gctactttag cttatacaga 80460 agcagttaac caacctgaaa ttattccagg agatacaaca gctcatattt ggggtagatt 80520 aatttcagca ccatttactg aggaacgtac aatctatcaa ggtcaagcat cagaaacact 80580 aaatgttaac ccttataata ttcctaataa acagggtgta cttaagttaa cacctagtga 80640 ggataactgg attgatactg aaaatgttac aatcactgaa caaaaaacta agaaagtaac 80700 tatgagacga ttttggagac ataatgaaag ttactacggt gagactgagc attacttgta 80760 ctctaactta caattagatt ccggacaaaa gtgggaaggt aaatcattag cttatgataa 80820 agcacatggt agaacaggta ctttattaga atcaggagga caacgtactc tagaagaaat 80880 gattgaattc attagaatca gagatgtatc cttcgaagtt aaagggctaa atcctaatga 80940 taataactta tatttattat ttgatggtgt aagatgtcct attactcctg caactggtta 81000 tagaaaaggt tctgaagatg gaactatcat gacagatgca aaaggaacag ctaaaggtaa 81060 atttactatt cctgcaggta ttcgttgtgg taaccgagaa gttacactta agaatgctaa 81120 ctctacaagt gctacaactt acacagctca aggacgtaaa aaaatcgttc aagatattat 81180 tatcagaact cgtgtaacag taaacttagt agacccatta gcacaatcat tccaatatga 81240 tgaaaacaga actatttcat cattaggttt atactttgct tctaaaggtg ataaacaatc 81300 taatgttact atccaaatta ggggtatggg tgaccaaggt tatcctaata aaacaatcta 81360 tgcagaaaca gttatgaatg cagacgacat taaagtatct aataatgcta gtgctgaaac 81420 tagagtatac tttgatgacc ctatgatggc tgagggcggt aaagaatacg ctattgttat 81480 tattactgag aacagtgatt atacaatgtg ggtaggtact agaactaagc ctaagattga 81540 taaacctaac gaggttatct caggtaaccc ttacattcaa ggtgtattat tcagttcatc 81600 aaacgcatca acatggactc ctcaccaaaa ctctgacctt aaatttggta tttatacttc 81660 taaatttaat gagacagcaa caattgaatt cgaaccaatt aaagatgtat ctgcagatag 81720 aatagttctt atgtctacgt acttaactcc tgagagaaca ggatgtacat gggaaatgaa 81780 attaattcta gacgatatgg catcttctac aacattcgac caattgaaat gggagcctat 81840 cggtaactat caagacttag atgttttagg tttagcaaga caagttaaat taagagcaac 81900 tttcgaatca aatagatata tctcaccatt aatgagctct agtgatttaa cattcactac 81960 gttcctaaca gaattaacag gttcatatgt tggtagagct attgatatga cagaggctcc 82020 ttacaataca gtaagattta gttatgaagc tttcttacct aaaggtacta aagttgttcc 82080 taagtattct acagatgatg gtaaaacgtg gaatacattt actaaacctg ctacaactac 82140 tagagctaac aatgaattta cacgatacac tattgatgaa aaagtaaact caaaaacaac 82200 taatactaaa ctacaagtta gattagactt atcaactgaa aatagctttt tacgtcctcg 82260 tgttcgtaga cttatggtta ctactaggga tgaataaact agaggggttg attgacccct 82320 ctttatttaa taaggagaga tttatatgcc tagagaagtt agagaccctt actctcaagc 82380 taagctgttt attcctacag ttgaagagaa atcaattaag gaattagaaa gaacatataa 82440 ggaaaaaatt aatgaagttg atagacttct taatgaatta aagaaagaga gaggagaaaa 82500 atagatggca tttaactaca cgcctcttac tgaaacacaa aagttaaagg atatgtatcc 82560 gaaggtaaat gatataggta acttcttaaa aacagaggtt aatcttagtg atttaaaagt 82620 aataagtggt gttgatttta ataatattct agacaagatt cctgacagcg gtaactatta 82680 tgtaacaact tctaaaaacc aaccaccagg aacaaattgg aatggttttg taagattaga 82740 taaaagagat aaatcatatt acaaaatata ttattcacct tttaatagta ataaaatgta 82800 tataaagact tatgctaatg gaacagtata tgattggatt agttttaaat tagatgaagg 82860 taatttatat aatgaaggta atactttaaa tgttaaagaa cttaatgaat ctacaataca 82920 gtacgcaaca ttagttaatc ccccaaaaga aaatttaaat acaggatggg ttaattataa 82980 ggaaagtaaa aatggtgtat catctttagt agagtttaat cctattaatt ctacatctac 83040 atttaaaatg gtaagaaaac ttcccgtaca agaacaaaac cctaatttac taagagatag 83100 tttatttgtt taccctgaaa caagtatttc taatattaaa acggataatt ggactgcacc 83160 accattttgg gggtattctt ctaatagtgg acgttccggg gttagattta gaggagaaaa 83220 tactgtacaa atagatgatg ggtctgctac ttaccctaca gcaatgacta atagatttaa 83280 aatgggtaaa gagctttctg taggagatac tataactgtg tcagtatatg ctaaaattaa 83340 tgaccctgct tacttaaag acaacatagt ttattttgaa ctggcaggat atgatactgt 83400 agatagaaca gataaccctt atacaggtgg acgaagagag ataacagcaa gtgaaataac 83460 tactgaatgg aagaagtatt catttacatt tacaatacct gaaaatacaa ttggtgcatc 83520 aggtaataag ataaactata tatctctact actacgaatg aattgttcat ctagtagagg 83580 taacggagcg gtagtatact acgctctacc taaactagag aagtcatcta aagttacccc 83640 ttttataact catgtaaaag atgtaaggaa atatgatgaa atatggtcta actggcaaga 83700 agttattagt aaagacgagt taaaaagtca ctcccctgta gatattgaat ataatgatta 83760 cttcaagtac caatggtgga aatcagaagt taatgagaaa accctaaaag atttagctat 83820 gactgtacca caaggttacc atactttcta ttgtcagggt tctattgaag ggacaccgaa 83880 aggacgttct attagaggaa ctattcacgt ggattatgat aaaggtgacc catataaagc 83940 taataagttt attaagttat tatttacaga tacagaaggt ataccttata cactatacta 84000 tggtggttat aatcaaggat ggaagacttt aaaacaatca gagacttcta ctttactatg 84060 ggaaggtgct ttagattttg gttctaccga atctgttagt ttaaacgatt cattggataa 84120 ctatgattta attgaggtaa cctattggac tcgttcagca ggacattttg ctacaaaaag 84180 attagatata acaaatacat cacatatatt gtatgttagg gattttaata tggcaaacga 84240 tagtacgggt tctagtatag acttttttga aggttactgt actttcccta ctagaacatc 84300 agtacaacct ggtatggtaa aatctataac tttagacggg tctacaaata caacaaaagt 84360 agcatcttgg aatgaaaagg gacgtataaa gatatatact attatgggaa ttaatagagg 84420 ataaaaaagg aggaataaaa actatggctg ttagacatga tataagtagt aacgatatag 84480 tattgcattt aagagaaggt aaatattatta caggatttac aacagtggga ggttatgacg 84540 aggaactagg acaggtaaaa gttaatagag aaattttacc tgcttatttc tttgataatt 84600 ttgcctatga aagatacttg tattatagca aaccggagga agttatagag aataaaaatt 84660 atgaaccacc taaaattaat gatgatgagg gagaatctca acaaaatact gtacctaaag 84720 aacaatatga tagtttaaaa gaagagctag aacttatgaa acagaaacaa gaagctatga 84780 tgaaaatgct tcaacaactc ttaggtcaaa aggggtaata ataaatggca ttaaatttta 84840 ctacaataac ggaaaacaat gttattagag acctgactat tcaggtcaat aacattggag 84900 aagaattaac aaaagaaaga aatatatttg acattacgga tgatttagtt tataatttta 84960 ataaatcaca aaaagttaaa ttaacagatg ataaagggtt agctaaagta tataggagta 85020 caactgttct tagagatata aaagaaccag ggtattatta tataaatgca agagcattag 85080 caatgatgac agataaacct gatatggaat caatagatgt tttactttat gtaatgcctt 85140 tagaatcctc tgatagagtg gtacagcact tgtataccct ctctaccaat aataatcaga 85200 ttagaaccat gtatagatat gtttcaggta actcaagttc agaatggcaa tttattcaag 85260 gactaccaag taataaaaat tctattatat caggctctaa tatagatgat ttaacttctc 85320 caggtgtata ctttgtgaca ggtatgacag gaggtatgcc tagtggtgta gattcaggtt 85380 ttttagattt aagtatagat gctaatgata atagattagc taaattaact gattctgaaa 85440 caggtaaaga atacactagt attaaaaaac ctataggtgt atatacagag tggaaaaaag 85500 aattagagcc aaaagatatg caaaaatatt tattgagtaa tatagaagat gatggtagat 85560 taacatttcc attaatggtt tatgcctcag acaataagac attccaacaa gctgttgtag 85620 accacataga cagaacagga caaacaacct ttacttttta cgttcaagga ggagtaactg 85680 gttcacctat gcctaatagt tgtcgtggat tattcatctc agatacatct aacactgaca 85740 gtctacatgg tatttataat gcagtaggga cagatggtcg ggatgtaaca ggttcagtag 85800 tagggagtac ttgggtttcc ccgaaaacag ccccatccta taaagaatta tggacgggag 85860 cacaatcatt ctcatctaca ggtaccacta agaatctagc ggatgacatt agtaattatt 85920 cttatgtaga ggtttatact aaacataaga cagcagagaa gactaaaggt aatgatgatt 85980 caggtacaat ttgtcataaa ttctacttgg atggtagtgg tacctacgtt tgctcaggaa 86040 cttttgtttc aggagataga acagatacaa aaccacccat tacagagttc tatagagtag 86100 gtattaactt ctcaggaaca acttggaaaa ttgtagatag tgcagtacaa aatagtaaaa 86160 ctcaatatgt tacaagaatt ataggtatta atatgccata gactaggaaa ataatcctag 86220 tctttttttc ttgacttaat aagtattcta tggtatacta taactcgtgt aaggatataa 86280 ggagattaaa atgagattaa gaattaagaa cttatatacc tatgtagaat ttgaggagga 86340 tgataaatac ttaaaagata tatttttaaa gagagttcat actactatag gagcaagaca 86400 agagggattc cagtatagtc ctgcttacaa aagaggtagt tgggatggtt atgtagactt 86460 ttatgtctat gaagaagata agttccctac tggactttta tttaaagttg agttattatt 86520 aggtgagtta caatcaagat ataacttcca gtttgaaacg attgatgagc gtgatgagag 86580 tttcttagct gaagaagata ttgatgatga gataacatta cttgataata atattggtca 86640 aattacttta agagactatc aatacgaggc agtttacaat agcctaacat tctataatgg 86700 tattgctcac ttagccacta atggcgggaa aacagaagtt gctagtggta ttatagacca 86760 actgttacct caattagaaa aaggtgaaag ggtagcattt ttcacaggct ctacagagat 86820 attccatcaa tctgcagaca ggttaaaaga acgactaaat attcctatcg gtaaagtagg 86880 agcaggtaaa tttgatgtta agcaggttac agttgtaatg atacctacat taaatgcaaa 86940 tcttaaagac ccgacacaag gagttaaggt tacacctaaa caaaatatta gtaaaaagat 87000 tgctcaagag atattaccta aatttgaagg tggtaccaat caaaagaaat tacttaaagt 87060 attacttgat aatacaacac ctaaaacaaa ggtagagcaa aatgtattaa atgttttaga 87120 actaatttac caaaacagta aaactgatgc agaggtctta ttaaacctaa agaaacataa 87180 tgctcatttc caaaaagttg ttagagaaaa gaatgaaaag aaatacgata aataccaaga 87240 tatgagagac ttcttagatt cagtgactgt tatgatagtt gatgaagcac accactctaa 87300 atcagactca tggtataata atctaatgac atgtgaaaaa gctttgtata ggattgcact 87360 aacaggttct atagataaga aagatgaatt actatggatg agactgcaag ctttatttgg 87420 taatgttata gctagaacta ctaataagtt cttgattgac gaaggacatt ctgctagacc 87480 aacaataaat attatacctg tagctaatcc taatgatata gatagaattg atgattatag 87540 ggaagcttat gataaaggta taacaaataa tgattttagg aataaactta ttgcaaaact 87600 aacagaaaag tggtataatc aagataaagg aacattaata attgtaaact tcatagaaca 87660 cggagataca atatctgaga tgttaaatga tttagatgta gaacactact tcttacatgg 87720 agaaatagac tctgatacta gaagagaaaa actaaatgac atgagaagtg gtaaacttaa 87780 agtaatgata gctacatcac ttattgatga gggtgtagat atatcaggta ttaatgcact 87840 aatactaggt gcaggaggta aatcattaag acagacacta caacgtatcg gacgtgcttt 87900 acgtaagaag aaagatgaca atactacaca aatatttgat tttaatgata tgacaaatag 87960 atttttatat actcatgcta atgagcgtag gaaaatttat gaagaggaag attttgaaat 88020 aaaagactta ggaaaatagg agggtaagag atggcaacaa aaacacaaag aaagttatac 88080 caatatctag aagaaaatgc tacagaaaat aaatttcata tttctactaa gaaagagcta 88140 gcggattctc tagacgtttc catctctgct ttatccaata accttaaaaa gttagaagaa 88200 gaaaataaaa ttgttactgt atctaaaaga ggtaaaaatg gtggcgtagt gataacttta 88260 gtgagagact ataatactga agagttaaaa gagtttaatg aatctaaaga taacattatc 88320 acttcaaact tacaatatgc caaagaactt agagagaaac atttcccttc atatagatac 88380 gagagaaaag aacagcgtag acgtactaag atagaaatgg ctcagtacaa cgccattaag 88440 gatgagaaga gaagaatcat agcagatatg aactttcatt cagaaggtct ttcttaccct 88500 tctaaagata tatttaatat gtcttatgac ccggaaggat tctataaagc atatatactt 88560 tgtaagcttt atgaccaata cgctatctct catatggatg ccaaacatac gagtcatctt 88620 aaagcaatga gtaaagcaaa aactaaagat gaatatgatt accatcaaca tatgtctgag 88680 tactatagaa ataaaatgat tcagaactta cctagaaata gtgtaagtga taatttcttt 88740 ggtagtaaaa catttaatac cttttataat ttttatttaa aaataaaaga taaaaatatt 88800 aatgtattta aatatatgca aaacgtgttt aagaatgtaa cattttatta tgagaatggt 88860 atgcacccta atccaatacc ttctcctaac ttctttagtt cagataagta ttttaaaaac 88920 tataataatt atattaaagg aataaaaaaa ggtgttaaca ataccaacag acacctagga 88980 gatacagata gtattattaa ttcttcagac tatgtgaaga atcctgctgt attacattta 89040 catcagttat atactacagg attaaattct accctacat atattgatac aatgtttgaa 89100 caagccttag acctagagaa tgcttcttac ggattatttg gaaatatgaa acatattgta 89160 ttactgcaat ataattctat gattgaagag gaagttaaga atttacctga agaagaaaga 89220 ggtattatta ataaatatgt aaaacaatgt ataattaatg aatattcacc gacaagtata 89280 tcaccttcag caagattatc aatgttcact atgcagaaag agtatattgt tcatgataga 89340 caattaaata atggtattaa acgagaagat ttactaccat taagcttagg tggtagagtg 89400 gataaagatt cacttagtgg aatggatata caaaacctag aacagaacgg taatgagtac 89460 ctttatatga gacagtatac ttctacttat tatatactaa gaatgtttgg agattattta 89520 ggctatgaag taaacttaag agaagtaaaa tatattgtag agaaatataa tttaattgat 89580 aaaataccct tgacaaaaga aggtatgttg gattataata aacttataca tttagtagag 89640 gaagaggtta ataactatga gtaaaaagat aaaggagctt attcttcata aatcaatgaa 89700 ggatatacat tttgcaagag aagtattaga taacttacct aagaacctat tctcagcaga 89760 gtctgaggat atgggttact tatttacagc tataaagaga acagcacaca tttccgataa 89820 gatgtctaat gaagcattag caattaaagt agaacagctt atgggtaata ataaggaaga 89880 tgaagagaga gtaactaaaa ctttaactta cttagaagat ttatacaaag tagatgttaa 89940 tgagaaagat gagtctgtta actatgaaat agaaaagtat attaaaacag aaatgtctaa 90000 ggaagtatta gttaagttta tagcagaaaa taaacaagaa gactcagaca acttacatga 90060 gcttgtagat aaattaaaac aaatagaggt aagtgatatt tcaggaggca acggggaatt 90120 tattgatttc ttcgaagata ctgaaaagaa acaggaacta ttaagtaatt tagctacaaa 90180 taaattctct acaggcttta cttccattga taatcacatt gaaggtggta tagcaagagg 90240 agaggttgga ttaattatag ctccaacagg tagaggtaag tcattaatgg cttctaactt 90300 agctaaaaac tatgtgaaga gtgggttaag tgtcttatat attgcattag aggaaaaaat 90360 ggatagaatg gttttacgtg cagaacaaca aatggcaggt gtagagaaaa accaactagt 90420 aaaccaggat atgtctttaa atagtaaagt ttatggtgcc ttacaaaatc attatcagaa 90480 gaatagaaag ttattaggtg acttttatat ttctaaacac atgccaggtg aagttacacc 90540 aaaccaatta gagcaaatta ttgttaatac tacaattaag aaagataaga atattgatgt 90600 tgttatcatt gactaccctc atctaatgag aaacccttat gctaagtatc actcagaatc 90660 agatgcagga ggaaaactgt ttgaagatat tcgtagatta tcacaacagt atgggtttgt 90720 atgttggact ttagctcaga ccaaccgtgg agcttatggt tcagatgtca ttacaagtga 90780 gcatgtagaa ggttctcgta agattgtcaa tgctgttgag gtatcattag cagtaaacca 90840 aaaagatgaa gaattcaaga gtggtttctt aagattatat ttagataaaa tccgtaacag 90900 ctctaacaca ggagaacgat ttgttaatct taaagtagaa ccaactaaga tgattgtaag 90960 agatgagact cctgaagaga aacaagaaca tattcaattg ttatctgata atgggaaaga 91020 agatacaagt aagtttaaag ataaagataa taaaatagaa gctataaata acacattcgg 91080 aggattacct ggaatttaaa tttttaacct ataccacttg acattttata tgttaggtgg 91140 tataattgtt ttataaacaa aaaaggagag atttataatg agaaatttag acccaataat 91200 taactttaga ttttttaata atagtaaacc cgaaggatat gtaatatttt taacaagtga 91260 gacagaaact agagggatga caattgaagt agcaagccct caagatagag tgtttgagct 91320 tgaatataaa ccaaatacaa ttattttgac agataacaat aataaaacaa ctacttatgt 91380 aaacgatgta gaaacttcat ctgaagaaat agaaaaacac ataaataaac ttattgaaga 91440 ggatttggag gatgaataat gaaatttata tttttcacag atagtcattt tcatttattt 91500 acaaactatg caaaacctga tgaattttat tataatgaca gatttagaga acagatagaa 91560 gcgttacagg aagttttcaa tatagctaag gaagaggaag ctattgttat ctttggagga 91620 gacttatttc ataaacgtaa tgctgtagat acaagagtgt ataatgaagt atttaaagta 91680 tttgctagaa ataaggatgt agctgtttta atgcttagag gtaatcacga tgccacaact 91740 aactcaatat atacagattc aagtatagat acttttaatt acttacctaa tgtaactgta 91800 tttacagctt ttggtgcaat tgaaaagaac aacgtaaata tagtattcac agcttatgga 91860 gatgaaacag aagagattaa agagtatatc aaaagtaatg ttcaggaaga taaggttaat 91920 gtacttgtag ggcatttagg tgtagaaggg tcattaactg gtaaaggttc tcatagatta 91980 gaaggagcct ttggatatca ggacttatta cctgataaat atgatttcat tttattaggt 92040 cattatcatc gtagacaata tttccaaaac ccgaaccatt tttatggggg ctcattaatg 92100 caacagtcat tttctgatga gcaggaagct aatggtgttc acctaataga tacggaaaag 92160 atgactacag aatttattcc aatccataca cgtagattta ttactatcca gggagaagat 92220 atacctgaaa actttgacca attagtagat gaagataatt ttattagact tattggtact 92280 tcaaaccatg ctaaggtttt agaaatggat gagaacatga gagacaaaaa tgttgaagtt 92340 cagattaaaa aagagtatac tgtagaaaaa cgtatagaga gtgacgtatc tgatgaccct 92400 ttaacaattg ctagtactta cgctaagcag tattcacccg aatcagaaca agaaatactt 92460 gaatgcttga aggaggtttt atagtgagaa aatataaaga atatctaaac aagtcagatg 92520 aagaaaattt agcagaagac tgggaacgga taaaagaaga tttatggaaa gtgtttaaag 92580 atatgaaacc taaaattaat acattagaca tcagtaatgt agtgagtaaa gatttagata 92640 aaagtaaacc tattttacaa tttcaagatt cagacagagt agtagagaat atttgtaatg 92700 ttgaaggttt agaagatggt ttatctaaaa tgaaaaagat ttttgacgat agtaattttg 92760 acaaacatta ctataataga attgtagaac atgatgaata ttattggatt gattatggtt 92820 ctcatcattg tttctttagg gttacgaaag gagataagta atggtagtat ttaaacaagt 92880 agaagttaat aattttttag caattaaaga ggctacatta gagttagata atagaggttt 92940 aatacttatt gaaggagaaa ataaatctaa cgagtcattc cattcaaatg gctccggtaa 93000 gtcaacttta atatctgcca ttacttatgc tttatatggt aaaactgaaa aagggttaaa 93060 agcagatgat gtagtaaata atattgagaa gaaaaataca tctgttaaac ttaagtttga 93120 tattggagaa gatagctatt taattgagcg ttatcgtaaa gataaagaga ataagaacaa 93180 agttaaattg tttgttaatg ataacgaaat tacaggttca acaaatgatg ttaccgataa 93240 gcagatacag gatttatttg gtattgagtt taatacgtat gttaatgcta tcatgtacgg 93300 tcagggagat attcctatgt tctctcaagc aacagataaa ggtaagaaag aaattcttga 93360 atccattact aaaacagatg tatataagca agcacaagat gtagcaaaag agaaagttaa 93420 agaagtagaa gaacaacaga ataccctaag acaagaaata gataaattag ggtatcagtt 93480 atctacaaaa gatgaatact ttaaaaagga agtagaacag tataatcaat ataaagaaca 93540 attggttcag atagaaaaca gtaataaaga gaaagataga ttaagagagc aagaagagaa 93600 gcaaatagaa gctcaaatag agcaattaac ttcacaggta ccaacaatac ctgatgaaca 93660 atttaatcac tcggaggact ataataaagc ctctcagagc ttagatttac tttctaataa 93720 attaactgaa ttaaatcaag tatatacaga ttataatact aaggagcagg tattaaaatc 93780 tgagataact acactaaata atagtttaaa tcagttagat acaaacgacc attgtcctgt 93840 ttgtggttct cctatagata actctcataa acttaaagag caggaaaata tcaataatca 93900 gattgaacgt aagaaacaag aaattactag tttattagga acgaaagata cgtacaaaga 93960 agctattgat aaagtaaata ataaagcaca agaaattaaa gacaagatgt cccaagaaga 94020 ccaacaagaa cgagagtata ataataagat taatagactc attcaagagg cttctaagat 94080 taaatcagat attagttcat tagagaataa taaaacctat ttaaaagtga aatatcagca 94140 tcaatctgtt caaggtttag aacgagaaga accaagcaaa gaaaaacatg aagaagataa 94200 aaaagaattg caaaatgcta ttgacaaaca tgaagaaaat gtagtacaat tagaaagtaa 94260 gaaaggtaag tatcaacaag ctgtagatgc ttttagtaat aaaggtatac gttcagtagt 94320 gttagacttt attacacctt tcttaaatga gaaagctaat gaatatcttc aaactttatc 94380 aggttcagat attgaaatag aattccaaac tcaggtgaag aatgctaaag gagaactaaa 94440 agataagttt gatgttattg ttaagaatag taagggcgga ggctcgtata aatcaaactc 94500 agcaggagaa caaaaacgta ttgacctagc aattagtttt gcaattcagg atttaattat 94560 gagtaaagat gagatatcta caaatattgc actttatgat gaatgttttg atgggttaga 94620 tactgtagga tgtgaaaatg taattaagtt attaaaggat agacttaata cagtaggaac 94680 tatatttgta attacccata accaaagttt agctccttta tttgagcaaa caattaaaat 94740 aataaaagaa aatggagtat caaaactgga ggaaaaataa tgaaattaaa gattttagat 94800 aaggataatg caacacttaa tgtgtttcat cgtaacaagg agcacaaaac gatagataat 94860 gtacctactg ctaacttagt tgattggtac cctttgagta atgcttatga atataagtta 94920 agcagaaatg gagaatattt agaattaaag agattacgtt ctactttacc ttcgtcttac 94980 ggtttagaaa gtaatgacca ggatattatt agagataata atcatagatg tagaataggg 95040 tattggtata accctgcagt acgtaaagat aacttaaaga ttattgagaa agctaaacaa 95100 tatggtttac ctgttataac agaagagtat gatgctaaca ttgtagaaca agggttcaga 95160 gatattggag ttatattcca aagtcttaaa actattgtcg tactaggta cctggaaggt 95220 aaaacagaag aagaattaag aatttttaac atgaaatcgg aagagtcaca attaaatgaa 95280 gcacttaaag agagtgattt ttctgtagac ttaacttaca gtgacttagg acaaatttac 95340 aatatgttac tattgatgaa aaaaattagt aaatagtaag gaaggatatt atgaggtttg 95400 aagacttttt aacccaagaa ttaggagaac caaaagagaa tactataggt gagctaagat 95460 actgttgtcc gttttgtgga gaaaaaagtt ataagttcta tgttaagcaa gctttagact 95520 ctagtaatgg tcaatatcac tgtaaaaaat gtgatgaatc gggaaaccct attacattta 95580 tgaagaccta ttacaacatt acaggtaaac aagcttttga tttattagag tctaagaaca 95640 tagatataga gagagcccct ttacttacaa ctaataacaa ggatttaaca gaatcagaga 95700 aacttatatt aatgcttaga ggagtacat aagatagagg aaatacaagt attaaaccac 95760 ctagattacc taatggatat aagttattaa aagataattt aaataataga gagattatac 95820 cttttctaaa atacttaaaa ggtagaggta taactttaga gcaaatcatt aataataata 95880 taggttatgt tactaacggg agcttctata aagttgatgg agaatcaaaa gtatcattaa 95940 ggaatagtat tatattcttt acgtatgata atgatgggaa ctatcaatat tggaacacac 96000 gaagtataga gaaaaacccc tatattaaat ctattaatgc tcctgctaaa caagatgaag 96060 taggaagaaa agatgtcata tttaatttaa atatagcaag aaagaaaaaa ttcttagtta 96120 taactgaagg tgtatttgat gctttaacct ttcatgaata tggagtagca acactaggta 96180 aacaagtaac agaaaatcaa ataaaaaaaa taattgatta tgttagtgta gacacatcaa 96240 tatattattat gttagatact gatgcattag ataataatat agatttagct tataagctca 96300 aaacacactt taataaagtt tactttgtac ctcatggtga cgaggatgca aatgatatgg 96360 gaacaaggaa agcttttgag ttgttaaaac agaatcgagt actagtaaca cctgaaagta 96420 tacaaagtta caaaatacaa caaaaactta aactttaggc ttgaccttag aagagtttta 96480 tgttatacta gtacttaagt aattaataaa ggagaaaaaa ataatgtcaa ataataaaaa 96540 agatatttta gaatttgtag atgaatacat tacagcttta agagttggta atgagcaacg 96600 acaacatcaa ttagaagaaa taggtaaaga agaaacagca acattaacag acgtaactaa 96660 agctattact aatcttatgt taggtgttaa tgagcaaatg acagacttag aatacaacaa 96720 tgagttaaac ttaaatattt taattgatgc tttatataaa gcagagctta ttaatgaaga 96780 tgtattaggc tacattcaag aatcaattga taaatcacaa gaagaaccta aaaatgaaga 96840 agaaaaagga gaacaagaat aatggaaaaa aatattagca cacacacaaa aggtattagt 96900 caagcagaca tggagaaatg gattgaagct gtagtacaag gaactgttga tggtaaacaa 96960 gttgatgaaa aaacagctaa acaattagat agaattggtt cacgtagtgt ttctttagaa 97020 gaagcaactc gtattgctaa agtacttaat gctgttacag ttcaagagat ttcaggagat 97080 tttaatgatg catttaatgc aattgactta atgatgatta tcatggaaga tgagttagga 97140 gtaactcaag aacaagttga aaaagctaag aataagttaa atgataaacg agaagcttat 97200 ttaaaagaga agcaagaaga attacgtcaa aaacaacaag aagaagtaca agaagaaact 97260 gaatctgaca gcaatgaaaa agtaattcag ttgaagaaaa atgacgaaca gtaagaaaaa 97320 aggagataca ttcgaacgta aaatagctaa agaataact gcttggtggg gatatcaatt 97380 taataggtct ccccaatcag gtggtgcctc ttggggtaaa gataataatg ctgtcggaga 97440 tatagtagta cctcaggaag ctaattttcc tttagtagta gaatgtaaac atagagaaga 97500 atggactata gataatgttc ttctaaacaa tagagagcca catacatggt gggaacaagt 97560 aatcaatgat agtagtaagg tgaataaaac accttgctta atatttacta gaaatagagc 97620 tcagagttat gttgctttac cttatgatga aaaagtatat gaggacttaa gagataatga 97680 atatcctgtt atgagaacag attttattat tgataatatt agaaaagata aattttttta 97740 tgatgtcctt ataactacca tgagtgggtt gacctcattt acaccttctt atattatatc 97800 ttgctacgac aaaaaagatg taaaaccata caagaaggtc gagtctaatt tatctgaggt 97860 aagtaaacat gaagatgaat tgattaatga ccttcttagt gatatataag gaaggtaaga 97920 taagtatgac gagtaaagaa agaccattaa ttgtatattt ttcaggtaca ggacaaacag 97980 aaagactagt aagcaaaatt aatattaata attcatttga aacgtttaga gttaagagtg 98040 gaaaagagaa agtagataaa ccttttatac taataacacc tacttatatg aaaggtgcaa 98100 tacctaaaca aatagaaaga ttcctagaaa ttaatgggag ccctaaagaa gttattggaa 98160 caggaaataa acaatggggc tctaatttct gtggagcaag taaaaagatt tcagagatgt 98220 ttaagattcc tttaattgct aaagtagagc aatcaggaca ctttaacgag atacaaccaa 98280 tattagaaca ctttagtaat aaatacaaag tagcgtaaag gatgagagat atatggcaac 98340 atatggaaaa tggattgagt taaataacga gataactcaa tagatgata atggaaaaaa 98400 taaactctat aaagaccaag aagctttaga tgagtattta aaatacattg aagataatac 98460 aagaaaattt aatagtgcag tagagagaat tagagtattg acagaagaag gaacttatga 98520 taagatattt gatagtgttc ctgatactat tattgatgaa atgactaagt tagcttatag 98580 ctttaacttt aagttcccta gtttcatggc agggcagaag ttttatgagt cttacgcatc 98640 aaaacagtat gatgaaaatg agaaacctat ttttgttgaa gactatgagc aacataacgt 98700 tcgagtagct ttatacctat tccaaaatga ttatgtaaaa gctagagaat tattgattca 98760 gctcatggaa cagacattcc aaccatctac accaacttat aacaactcag gacaagctaa 98820 tagaggtgaa ctaagttcat gttatctatt tgtagtagat gattcaattg agtctctaaa 98880 ttttgttgaa gatagtgtag ctaacgctag ttctaatggt ggcggagttg caattgactt 98940 aactagaatt agacctaaag gtgctccagt acgtaataga cctaactcaa gtaaaggtgt 99000 tattgctttt gctaaagcta ttgagcataa agtaggtatt tatgaccaag gtggagttag 99060 acaaggtagt ggtgcagtat accttaatat tttccataat gatattttgg atttattaag 99120 ttctaagaaa attaatgcca gtgaatcagt tagattagac aaattatcta ttggcgttac 99180 aattcctaat aaatttatgg aattagttaa agaaggtaaa cctttctata cttttgacac 99240 ttatgatact aataaagtat acggtaagta tctagatgaa ttaaacattg atgaatggta 99300 cgaagaacta ctaactaatg ataagattgg taaagtaaaa catgatgcta gagaagtcat 99360 gacagatatt gctaaaactc aattagaatc aggttaccct tatgtattct atgttgataa 99420 tgctaatgat aaccaccctc ttaaaaactt aggtaaagtt aaaatgagta acttgtgtaa 99480 acaaatgcac ctttaacgag taatcgttat cgaaaaatcc atctaaaacg gggaagccta 99540 cgtcaaatga tatggtaatc cgttgctaaa tatataaatt gtaatcactc ataggagagt 99600 gatattatgg aaaataaacc tataggagct gtttatgtta ctacatgctc tgtaaatggt 99660 aaaaagtaca ttggaaaatt tctttatgat agaataaatg actgggaaaa gtacttaggt 99720 tctggtagat acctacaaga agacattaag aagtatggta aagataagtt tattaaagaa 99780 attataaaaa attactatac gacagaagaa ttagaaaagg ctgaagaaga attaatatta 99840 aaaaccaatg cagtttatga tgacaactac tataatgtaa aactatcttc cgtaggagga 99900 gacatattca caacaaaccc tcgaaaagaa gaacttagag agatgagaaa acaacaaatg 99960 agcggtcaag gtaatcatca gtatggtaaa cctaaaacag aaaagatgat aagctctgta 100020 aagaaagcta actctagagc aatagagata gatggtataa aatatgagag cacatccaag 100080 gcatctagaa ctttaggtat aggacataca acaattggtt atagattaga ttctgataat 100140 taccctgagt ataaaaggtt aacacctaga aaatttgaaa agaaatgatt acaatttata 100200 ttaaatgccc aacgactatc tgtaacctat tcacataagt gaagggataa ggttagagcc 100260 aagtggtcaa ggtatcgagt aataatcgtg taaatccttg ttaaatcgaa acggtggact 100320 tcctataagg aagaatgata tagtctactc tatatggaaa catatagcag tcttaataga 100380 agacggacaa tgattaacga ccattgttga atatacagga cagaaatttc acaattacaa 100440 gaggtatcag agatacaccc ttatgcatac agcaatcaga atgttattaa tagagatgtt 100500 gtttgtacat taggttcact taacttagtt aatgtagttg aaaaaggttt attaaatgaa 100560 tctgtagata tcggaacaag agcattaact caagttactg atattatgga tttaccgtac 100620 ctacctagtg ttcaaaaagc aaatgatgac attagagcta tcggtttagg ttcaatgaat 100680 ttacatggac ttttagctaa gaatatgatt agttacggtt ctagagaagc attagaccta 100740 gtaaatagtt tatatagtgc tattaacttc caatctatta aaacatctat gttaatggct 100800 aaagaaacag gtaaaccatt taaagggttt gaaaagtctg attatgctac aggtgaatac 100860 tttgtaagat atattagaga gtctaaccaa cctaaaacag aaaaagctaa gaaagtatta 100920 agtaaagttt atattccaac tcaagatgat tgggatgaat tagctaaagc agttaaggtt 100980 catggattgt ataatgggta tagaaaagct gaagcaccta ctcaatctat atcatatgta 101040 cagaacgcta caagctcaat tatgcctgta cctagtgcta ttgagaatag acagtacggg 101100 gatatggaaa catactaccc aatgccttat ctaagcccta taactcaatt cttctatgaa 101160 ggagaaacag cttataagat tgataataaa cgtattatta atacaagtgc agtagttcag 101220 aagcacacag accaagcagt atctactatt ctttatgtag agtcagagat accgactaat 101280 aagttagtat cattatacta ctatgcttgg gaacaaggat taaaatcact atactacaca 101340 cgttcacgta aactttctgt tattgaatgt gaaacatgtt cggtttagaa aggaaataga 101400 tatggatatt acacaaaagg taaaacaaca taataaaaat gcagtattaa aagcaacaaa 101460 ctggaatatt gaagatgacg ggatgtctga tgtattttgg gagcaaggaa tctcccaatt 101520 ttggactcct gaagagtttg atgtatcaag agatttaagt tcttggaaca gtttaactga 101580 gagtgaaaag aacacttata agaaagtcct tgcagggctc acagggctcg atacaaagca 101640 aggaggggaa ggtatgaact tagtatccta tcatgaacca agacctaaat accaagctgt 101700 atttgcgttt atgggtggta tggaagagat acatgccaaa tcctatagtc atatctttac 101760 aacattacta aataacaaag aaacaagtta tttgttagat acttgggttg aagaaaatga 101820 atttttaaaa gtaaaagccc agtttattgg atattattat gaccaattat taaaacctaa 101880 ccctactgta tttgatagat acatggctaa agtagctagt gccttcttag aaagtgcatt 101940 attctactcc ggattctatt accctctact tcttgcagga agaggtcaga tgacacaatc 102000 aggagctatc atttataaga ttactcaaga tgaagcttat cacggttcag cagtaggatt 102060 aacagctcaa tatgattaca accttttaac agaagaagag aaaaaactag cagatagaga 102120 gacttatgaa ttattaaata ttctttatac taatgaagta gcatatacac atagcctata 102180 tgacccatta gaattaagtg aagacgtaat taactatgtt cagtataact ttaataagagc 102240 acttcaaaac ctaggtaaag aagattactt taatcctgaa ccttataacc ctattgtaga 102300 aaatcaaact aatgtagata gattacgaaa tgtagatttc ttcagtggta aagcagacta 102360 tgaaaaatct acaaacatta aggatattaa agatgaagat ttctcattct tagacagtaa 102420 agaatatagt actgctaaag aattcctata aaaaggagaa aagatattat ggatagaaat 102480 gaagcaatgg atttactaag caaaacagaa acactattta aaaaacatga tgagttttca 102540 tgtgtaagtg atatcaatga ccctatgaag ttattcagca actctaaaga tgctaaagct 102600 gatgacactt ctaagtcatt tcagttagag tttatgcatg atatgacgat gtacacttta 102660 tcctatggct caggtcaatt aaaacttatt gacctagcag aaggatatga agcacagaaa 102720 gcaacagtag ttaactcatt tcccgaaatt attaaaacat tagaaaagga tgattcagaa 102780 gatggaaaaa atggatagtt tagtagactt aaatacagca attagacaaa agaaagatgt 102840 tattgtaatg attacacagg ataattgtgg taaatgtgaa attttaaaaa gtgtaatccc 102900 tatgttccaa gaatcaggag atatcaataa acctatcttg acacttaatt tagatgcaga 102960 agatgtagat agagagaaag cagttaagat ttttgatatt atgagtactc cagtgttaat 103020 cggatataaa gacggagagc tagttaagaa atatgaagac caagtgacac caatgcaatt 103080 acaagaatta gagtcacttt aatttgtaat ttcctgctat ctgtgctata ctataatagt 103140 acaaggtagt aggatttttt tttaatgaaa ggaagatgac atatcgcaaa gaataaaaca 103200 ttaacgatat acaatagtga cagatatttt aatatacaca caaaagataa agataaaatt 103260 aatgaggcta ttaaagtaac acacagtaat gaagaagaga ttgaaaagga tatggacgag 103320 ctaatatcta aatctagacg atacgtcatg agagatgaaa atcattatat gttatttaat 103380 gagaaataca ataatgatag acttatagag aaggtatgta aacacggtgg taaaattaca 103440 tactatacag attcagtatt accctattat gtattaaaag atttatctag ccatcctgat 103500 tcagaggttg tttatcgtat gcgtaatggt tttactgcaa aagaggtaga taatatagct 103560 ctatcattca tgggaacaaa agttattatt gatatttcag tggtatttcc gtatgtaaac 103620 ccttatgata ttattagaag cttacatgat attaaaacaa acgtagatga agttcattta 103680 tcattcccac gtatactaga agtagatgaa aaacaagaaa aattctattt ctttgatgga 103740 gaagcttatg atttaaaacc tgaatataaa gtcgattttg cagataaaat tagagtatcc 103800 ttatcagtat ggaaaatgta tatctatatc ttaacaggta gtcgtgattt tgaagatgta 103860 gacgatgtaa ttacgaaact gaaacaacaa cgaaagatta agatataagg tgattatatg 103920 agtacagcaa atagaagaga tatagcaaga aagatatcag agaatacagg gtattatatt 103980 caagatgtag aagaaatact aagtgcagag acagatgcta tttcagactt attagaagaa 104040 gggtatacta aagtaaagaa ccataagttt ctgcaaatag aggttattga aagaaaaggt 104100 aaaaaagcat gggatggtct gaataaagaa tatttccatt tacctgatag aaaagctata 104160 aaatttaagc cacttaaaga actagaagag gttattgata gacttaatga agaagagaaa 104220 taattctctt ctttttttat tgacagggtt taaaatatat gatatagtat tattaagtta 104280 aaaaaggaga ggaactaaat gaaagtatta atcttattcg accacattag agaagaacac 104340 ttttctgtaa gtaaagatgg gggtgtgaag tctaatgtat taaatacacc taacggaaaa 104400 acacttaaga agttacttga gaagtgttct aacttaaaga gagataaaac aaatagagac 104460 tatgatattg attttcttta taatgcagta cctacaccta ttcgaaatga ttatggtaag 104520 attattaaat atcaggatgt taaacaagca gaagtaaaac catactatga aagaatgaat 104580 aacattatta ttgataatgc ttacgatatg attattcctg taggtaaatt aggagttaaa 104640 tacttattaa atgttacagc tatcggtaaa gtaagaggag taccaagtaa agtaacagtt 104700 gaaaatgaaa catcttctca tgatgtatgg gtattaccta cgtatagtat tgagtatact 104760 aatgtaaata aaaatagtga acgtcatgtt gtatcagatt tacaaacagt aggtaagttt 104820 gtagagcaag gagaagaagc ctttaaacct aaagaagtat cttatgaatt agtagataac 104880 attgaaagag ttagagaaat atttactaag gaagtaacga atgataatta tgatggagta 104940 gatatcactg catgggactt agagactaac tcattgaaac ctgataaaga aggaagtaaa 105000 cctctagtat tatctctatc atggagaaat ggtcaaggtg taactatacc tttatacaaa 105060 tcagacttta gttgggaaaa tggtcaagat gatattgatg aagtattaga gttgtttaag 105120 aattggttag ctagcaaaga agatattaag gtagcacata atggtaagta tgatattaaa 105180 ttcttaatga gtactgagaa ctttaaagat tttgagagta ttcaagatac taaagtaggt 105240 tggtacttag ctgtaacaca agaagttaaa gagtcactaa gattatctga tttagcttat 105300 gaagtaacag atgtaggtgg gtatgataaa cctttagaag actttaaatt atggtttgtt 105360 actaagttac taagattttt ctctgataaa attaaagaaa tacaaaaaga gaataaaaag 105420 gttgctaaga aagaatatga cattaaagct cctgaatata aagagtggtt agataataag 105480 ctagaagaaa ttacagatga gattaagtta gaaaacaaat atactcagtt aggactaaca 105540 cctgaggttg ttaacataga ttgtactatg gaagatgact ttaaggttat tgcagaacaa 105600 tcacctgaat atatgggatt atctaatgaa gctaagtctt acacactaaa tactgcaatt 105660 ggtttaatta ataagtatag agatgtaaaa gatgtagtga atgatattga cggaggtaac 105720 tttaactatg attggttccc tattgaatta atgcatccat acgcatcagg agatacagat 105780 gtatgtagaa gaattcactg tgatgtagtt aagaaattag aagaacaaga tagacctaag 105840 tctatgcatt tattagaagt taattaccct agattaacta aatcactagc tagaatagaa 105900 tcaaatggtt tatactgtga cttagactat atgaaagaaa atgatgagtc atatgagact 105960 gagatggcta agaaccacgc tacaatgaga gaacattggg ctgttaaaga gtttgaagag 106020 tatcagtata acctttacca aatggcgtta gaagagcatg agaagaaacc aaaagaaagg 106080 gacaaagata ttcaccagta tagagataag tttaaagatg gtaaatggat gttttctcct 106140 agttcaggag accataaagg tagagtaatg tatgatattt taggaattca attaccttac 106200 gataaagagt atattaaaga aaaaccattt aacgctaatg ttaaagaagc agaccttact 106260 tggcaggatt ataaaacaga taagaaagct attagttatg cattagataa cttagattta 106320 aaagatgatg ttaaagaact tcttgaatta cttaaatatc atgctagtat gcagacaaaa 106380 cgtaattcat tactaagaa attacctaat atgattaata aacaaaagag aacattacat 106440 ggttctttct ctgagacagg tacagagaca tcacgattaa gtagtagtaa tcctaactta 106500 caaaacttac cggcacatac gtcagatgta aacaagtttg attataaaca tccgattaaa 106560 cgttcatttg tttctagatt tgaaaacgga gtactactag gagccgacta tagtgcccta 106620 gagatgcgta ttattggatt atttactaaa gacccggata tgctacaatc attcctaaac 106680 ggagaggata tccataaagc tactgcaagt attgtttata acaaaccagt agaagaagta 106740 actaaagaag aaagacaagc aactaaagcg gttaacttcg gattagcctt cggtgaatca 106800 ccattctcat ttgcaggaaa aaacaatatg tcagtagagg aagcagaaga gatatttgaa 106860 aagtacttcc aaactaaacc tagtgtaaaa acttctattg acaatgtaca tgagtttgtg 106920 caacaatatg gttatgttga tacgatgcat ggtcatagac gcttcatccg ttcagctcaa 106980 tcagcagata aaaagataaa aaatgaaggt ctaagacagt catttaatac tattatccaa 107040 ggttcaggta gtttcttaac aaatatgtct ttaacttact tagatgactt tattcaatct 107100 cgtaacttga aatcaaaagt tattgccaca gtacacgata gtatcttaat tgattgtcct 107160 cctgaagagg ctaagattat ggctaaagta acaattcata tcatggaaaa cttaccgttt 107220 gatttcttaa aagcagagat tgatgggaaa gaggtacagt accctattga agctgatatg 107280 gaaattggtt taaactataa cgatatggtg gaatatgacg aagaagaaat agaaacattt 107340 aactcttacc aaggttatat taagtacat atgaacttac aaacactaga agactataaa 107400 gagtcaggta agttaacaga tgaacaattt gaaaaggcta ctaatgtagt taaaggtgag 107460 aaatctatct atcaagaaat ttaaaaaaag tattgacaaa atgtttaact tatgctatac 107520 taattaagta ataaagataa ggaggaaaaa cagtgaatac aggagaaatt agatttaatc 107580 gttctatgga tgaatggatt ataacaagca tgtatcagaa tgaattaggt gaaatgaata 107640 ttgttgttac attctataat agagaagaaa ataaacatgg ttctacagtc ttaccaacag 107700 agtcatctac tggggaagta acagaggaat tagcaagtct tgaggaagaa taccctttag 107760 ccttaccttt aagtagtatc tcagttaata tttaaaagga ggaactggta aatggaaata 107820 cacatgatt ccctagattt tacaaatttt actattaaag atagaaacgg gaactcacaa 107880 gagtttgata ttacagatga attaaagatt acagaatata cgattcaaga ggactttatg 107940 caacaatcag ctaagtatgc tttttgggct tctatattag agaaggtcag agcatattct 108000 gaaatggaac aacgaaacct agaaacagtt ggtagtaagt taaaccttag aattagacaa 108060 gagtatgaac aacaaggaaa gaaacctact aaagatatga ttgagtctag tgtatatatt 108120 catgactctt accaacaaca gcttaaagtt gttgaggctt ggaattacaa agttaagcaa 108180 cttcaatatg ttgtaaaagc atttgagaca agacgtgaca tgatgataca attaggtgca 108240 gaattaagac agacaaataa aaacggtgga attactaatc cgttttcaca ttaaaaaata 108300 aattaaaaaa tataattgac aaacataaaa aactatgtta tactaaataa gtaaattaat 108360 taaaaggaga aaagataatt atggatttca atcaatttat taacaatgag gcaagcaaat 108420 tagaaagcag taacagttct ttcaacaaca atgtagagag ctataaacct aaaaaccctg 108480 tattacgatt aggtaacgtt aaagatgcaa acggaaataa agttactaaa gaaaatgctt 108540 ttgtacgagt attacctcct gcacaaggaa caaatgtttt ctttaaagaa tttagaacaa 108600 caggtattaa ctactctaag aaagacggtt ctcaaggatt cacaggatta acattacctg 108660 cagaacaagg ttcatcagta cttgaccctt acattgatag ttggatagca aatggtgttc 108720 aattcagtag attccctaat aaacctgcag tacgttatta cattcatgtt attgaatact 108780 ttaataacaa cggacaaatt caacctaaaa cagattcaca aggtaatatc atgattcaac 108840 cgatggaatt atctaacaca ggatataaag agttattagc aaaccttaaa gatactatgt 108900 taaaaccatc acctaacgca cctcatagct ttatctcagc aaatgaagca ttcttagtta 108960 atattgctaa agctaaaaaa ggtgaaatgt cttggaaagt aagtgtttat cctaacgctc 109020 cactaggtgc tttacctcaa ggttgggagc aacaactatc tgacttagag aaattagcac 109080 aaccaacaga agagcaaaac cctaactttg ttaacttctt aatcaataac gttaataaca 109140 cggaattaag tcatgataac tttaagttta accgtgagac aaatgtgtta ggtgaagagc 109200 cttcagcacc taagcaagag cctactcaac aagatattga tagtcagatg ccaagtaata 109260 ttggcgggca acaacaggct cctgtacagt cacagcaaca acaacaacaa caacaacaac 109320 aaggtaatgt tgattggaac aacttagctc aacaacaatc acaacctgac tcaaaccctt 109380 tcaatgactt tgatgtaaat agtattgatg atgtacaagt acctttcaat actcaacctc 109440 aaaatacaca acaagcacct gaaccacaac ctgaaccaca acaaactact caggagcctc 109500 caaaacaaaa acaaacacaa agtattgacg atgtattagg tggtctagac ttagataacc 109560 tataagatat agagtgcctt agagcactct tttatttaag atataattac aatgtaaaaa 109620 ttgtggtatg atagaagata gagatataaa tgcaagtatt aatctaaaac aagcaaaaga 109680 atacacagta ctagtgtaaa agaaaggaag aagtttgcta ttgagttagt acaacttata 109740 aatgattaaa catacggtga gatacatcgg aattaacgct ctcggagtag ttttttagaa 109800 ctgttcttaa taaaggacaa ctacgttgaa cagagaaatt atccttcatt tataagtttt 109860 aataagcaaa tgaggcgtat cgcaagagca aaaaaaggaa aagaagtaga tttaacagat 109920 ttaaatacaa ttgatttagg taaagaatta ggattaacat tattatcaga tacaaacaga 109980 gcagatatta agaatgttat cccgacaatg gttcctcagt atgactatat tttaggtggg 110040 ggtattccgt taggtagatt aacagaggtc tacgggttaa caggttccgg taaatcaaca 110100 tttgcggttc acttatctag aattgcaaca caattaggtg ttattactat ttggattgat 110160 attgaaggaa cagcagataa taatcgtatg gaacaacttg gagtagatgt ttcaaaacta 110220 ttctctatcc aatcaggaga aggtagactt aaaaatacag tagagctatc tgtagaatct 110280 gtaggtaaag aattagagta ctggattgac acctttaatg aaaagatacc tggagtacct 110340 attgtgttta tttgggactc attaggagct acacgaactc agaaagagat tgacggcggt 110400 attgatgaga aacaaatggg acttaaagca tcagctactc aaaaagtaat taatgcagta 110460 acacctaagt taaatgatac aaatacaggt ttaattgtta ttaaccaagc tcgtgacgat 110520 atgaatgcag gtatgtatgg tgaccctatt aagtctacag gtggtagagc atttgaacat 110580 agtgctagtt tacgtattaa ggttcataaa gcgtctcaac taaaacagaa gagtgaatta 110640 actggtaaag atgagtatca cggtcatatt atgcgtattg aaactaagaa gtctaaacta 110700 tctagaccag gacaaaaagc agaagtagac ttactatctg attatatggt aggtaaagac 110760 gatgacccta tcttattgaa cggtattgac ttagaacata ctgtatataa agaagcagtt 110820 gagagaggtt taattactaa aggtgcatgg agaaactatg ttacattgaa tggtgaagaa 110880 attaaactta gagatgctga atgggtacct gtattaaaag ataatagaga gttatattta 110940 gagttattca gtagagtata cggagaacat ttccctaatg gatactcacc attacttaat 111000 aacaaagtaa ttgtaactca actagaagag taccaagcat tagagaaata ttatgaagaa 111060 tgggctacag ataataaaca agaagaacaa gaggaagaac caaaaggaga atctcaagaa 111120 aaggattctg aataatagat ggataattta atagataaaa acatgaacca ggtaaaagaa 111180 tctttggggg atgcaaattc ctcagatgtt cttcctttac cttataaaga tatagcaaag 111240 aaatttgaag aagtaaaaga aaaaggtgaa tcaattatca ttgaagaagg tggattccct 111300 tatacagatt ctacagtgat gtatatagaa catgtaacag atagatgggc gggaggatac 111360 tccttaatta gacatgaagg tgaagaggtt aaagtaccta aaactatcca tttctctgat 111420 atatatgtta aagataaatc acataaagta agaataatct tcgagggggc taatccttat 111480 gaagaaagct aacaatggta atagatatgt aatagatata gacggtattc ctgttgattt 111540 tgaaagagac ttagatagct tacttaatag gtataaaaac cttagatggg cattatacca 111600 taaatatgcg ggtattttat ctaatgactt tgaaagacaa gagttaagag aatacattga 111660 tgagcaattt attaaactag ttaaagagta taatattaga agtaaagtag atttccctgg 111720 atacattaaa gctaaactaa ctctaagagt tcagaatagc tatgttaaga aaaatgaaaa 111780 gtacaaacgt actgaaatta taggtaaaaa agattataca gtagagtcct tgactgagga 111840 tttaaatgag gactttgagg atagtcaaat tatgagttat gtatttgatg atatagagtt 111900 tacagaagtg cagagtgaac tacttaaaga attacttatt aactctgaaa gagaagatga 111960 tgcttttatc gtttctcaag tagcggagaa gtttgatatg aagagaaaag aagtagcaag 112020 tgaattgaca gaattaagag attatgttag atttaaaata aatgcatacc atgagtacta 112080 tgcaaagaaa gaattaaata accatagagt taatactgaa aatcatattt gggaaaacta 112140 gttacggtgc cttccttgtg ttatattatt atcgagaatt caataataaa gcatagggaa 112200 ggctttttct atgtcttata gaatgcttta aaatagatta ctaaaataaa gattggagat 112260 taagcttatg gctaaaaaga atgttaatga tgtattacag caagattctg ttacagtagc 112320 agataaatat ttacaagtta aggttaaccg tgacggttat actcgtacac atgaaggaca 112380 gtatgcgtac aaagtagttt cagagggaga agaattattc ttatatccag tacaaactga 112440 tggtaaaggt acattaaata ttatgaagaa atcacctatt gcttacactg atggagataa 112500 catccatttt gtagtaaaca cagtagtaga cccttataat cactcattta tccgtactga 112560 agatattaaa ggattagata agggtaaaca acttatccaa gctttcttag ctttcgttga 112620 agaccgtttc aaatttggtg tttataacgt atttgttgca aataataaag aagatgtatt 112680 agctatcgta gaccctgcag atactgatgc agacgaagtt aaagatagtt ttaaacatgc 112740 acatgaagat gtaattgcgg atttccctgc tagtcctgcc cgtaaagatg ttaaaggtgt 112800 agattcagga gaaggtcaag gagatacttc agagccttca gcacctgaga atgtaaaagt 112860 tacacctaca gaaaatagcg cagacgtaac agcagaataa tatatagata aaggatggtt 112920 taattggcta aattaaattt atacaaagga acagaattaa ttaacagcgt agaaaaaaca 112980 gaaggtaaaa ctactattac tattgaagga ttaaaggcta atacagatta ccctaaaggt 113040 acttatcaag tatcattctc taatgactca ggagaatcag aaaaggtaga tgtacctcag 113100 ttcaagactg atgctattgg tgttgcttcg gtaacactag acgttgaaag tttagattta 113160 acaatcggag atacacatca gctacaagct acagtagctc caagtaatgc atcgtataaa 113220 gctgtaagtt tcacaagtag tgacgatgct attgcaacgg ttgataacaa aggattagtg 113280 actgctgtct cagcaggtac tgctgacatt actgttgaat caatagcgga cggtagtaaa 113340 acagctaaat gtgctgtaac agttaaggaa cctattcctg aagcacctac agatgtaaca 113400 gtagaccctg gtgaaaatag cgcagatatt actgcatagg aggacaatta agaatggaaa 113460 agacattaaa agtatataag aatggtgaag ttgtaggctc acaagtagct aatggagatg 113520 gagctacaac agtaactatt acaggtttag aagcaggaac aaattaccct gcgggaactt 113580 ttaaagtagc atttgctaat gattcaggtg aatcagaaaa agcagatgta cctgaattca 113640 ctactacagc acctacagaa gaagaaccac ctgcagaacc tgaagcataa taattaagac 113700 caactaaaaa aagttggtct ttttttattg acaatatact tatcttgtgt tacactatat 113760 aagaattaag aaaaggaggg aaagtaatgg atattccaac aatattattt agaaatccat 113820 atgattacac aaaagtaaaa aaattaatgg aaagtaaaga gcagtacatt gtagtaaagt 113880 ttgattcagt ttctgttcat aacttaaatg ttcaaggtat gatgaacgtc attcaagatt 113940 acctacacat ttatggttac agagttaaag aatacgggca agaaaatgct tctaaagatg 114000 atgaaagaga cgttaaaggt tacttatacg aaagagtagg tgactaagtt atgcaagtta 114060 tagtaaatgt taaccatgtt caatcaaata ctattagtgg taccgaagaa ttttttaata 114120 ttatacaagt agatactttt agagaaggat tactgcagat agaagatgaa ccgactgtac 114180 tagcaggatt tatatatgat gataaaatat ttaaagatgc tgtaactcaa gaccctagca 114240 ttctgatgaa cattgaagat aacgatatcc tatatgtatc agatgttggt gtattaccaa 114300 atccatttgt tactgtagaa gaagataaaa agtattattc actattacaa caaattgtag 114360 aactaagtaa tgaagacata cctgaatcta tagtaagaga ttcaaaagat ttaactaggt 114420 attataactt tcaagatttt gaagatgtat tcgatttaaa tagaatttat aaaaaagaag 114480 ttgacacagt aaaagaaaag tgctatacta atggtaatgt atatttatta tatgaagttc 114540 tgccggacta taaactacct ttagcctata ggttacttga agataaggaa catggtattg 114600 ttattatagg ttcacagaca cgttctaata atgatatact gactttttat gttaaaggta 114660 tggatactaa gtcaatagca agtatgttcg gagtagagca ttactctaac tctaacgtat 114720 ttcatacatt cataaatagt cacattaaca ttttaggaaa tcaaataact aagtttataa 114780 aagagaaagg aagcagttat gagtaaatat aaaacagtag aagaagtaca agcagttatt 114840 atcggagtat tatttaagga tgaaggtaaa attgtaacat ccaagtttaa taaaattact 114900 aaagagtttg gtttagatag aataggtaaa gatgacctta aagaaattgt tgaagaaatt 114960 agacaagatg aatatctaaa tgaacttaaa aacaaagcaa ttaaaggtaa agtaacatta 115020 ggagacctta aagatgttgc agacaatcaa gtattcgaag gtaataacta ccatgaagaa 115080 gtatcttctt atgtagtagc taaagaaaaa gaactatctc acttaagaga acaacgtaaa 115140 cataacagac ataccgcata tcctcaaatt atgtttgatg aacttaaaga acatatggtt 115200 aaagaattaa aaggagaaac attagtagaa catcacagaa gtaaagctaa tattaatgat 115260 acagagttaa ttgtattatt atccgacttc cacataggta aattttgtgc ctaggtatat 115320 agaaatatat actaagtatt cttttaattg actgggaggc taaggcttta aagctatgct 115380 aatcagcatc caagttctat ttttttaata tacctgtata tcactaaata ttaagaggtg 115440 atatgaataa tggagaaaca aataaataaa ataaaaggtt ttgaattagt aagcccaaac 115500 cattatattt ctgactcagg tgaagttata tcttacagag gaggaaaaaa gagagtatta 115560 aaacctgctt ttagtaggaa gggctatcta agattatctc tttatcaaag agaattaaaa 115620 aaaggtaaac ctgttactat tcatagatta gtagctttag ctttcatacc taaccctgaa 115680 aataaagaac aagttaacca taaagatggt aataaaacta ataatgatat tagtaacctg 115740 gaatgggtaa caaataaaga aaatatgact cacgcctggg aaaataatct aagggataat 115800 ggttgggcta aaggtaaaaa taactaccaa tgggatggta atcataaaaa ttgtagagaa 115860 gtaatacaaa aagacttaga aggtaacatc ataaatactt ataaatctat agctatagcc 115920 agtagagaaa ctggattagg tgttaacggt ataggtaaaa catgtagaaa agaaactaag 115980 tctaataact ataaagggta tatatgggaa tttaaaaaat agaaaaggtt caacgactat 116040 ccctcggacg aatgtggcta aataaatcgt caataggagt agggctcaag ttaatggagt 116100 gggtgagaat cccttaaatc gaaatggaga acccctaatc taattagggt gaagatatag 116160 tctagtctta taggaaacta taaggagttc ataagagaac cggtaaaaga gttacgtctt 116220 ttattgaatg ttacgtcaat tgtatctgat atgactaatg gtaaatacga ttttgaagtt 116280 cttaaatcaa gactaaatca ctttattgat actacagtta aagagattga ggatagagat 116340 atttctaatg taactgttta ctttgtcggt gacttagtag aacatattaa catgagagat 116400 gttaaccaag catttgaaac agagtttact ttagcagaac aaatctctaa aggtactcga 116460 ttacttattg atattctaaa tgtgctttct gatgtagtta caggtgagct aagatttggt 116520 attattggcg gtaatcatga ccgtatgcaa ggtaacaaga atcagaagat ttacaatgat 116580 aatattgctt atgtagtgtt agattcttta ctactattcc aagagcaggg attattaaat 116640 ggtgtagata ttattgataa tcgtgaagac atttacacta tcagagataa ctttggaggt 116700 aaatctatta tcattaacca tggagacggt ttaaaaggta aaggtaatca tattaataaa 116760 tttatcttag atagtcatat tgatttacta attacaggtc atgtacatca tttctcagta 116820 aaacaagaag actttaacag aatgcatatt gtagcttcat caccaatggg ttataataac 116880 tatgctaaag aattacacct atcaaaaact aaaccatctc aacaactgtt atttgtaaat 116940 aaagagaata aagatattga tattaaaaca gtatttttag attaaggatg attaacaaat 117000 ggatacaata tttattataa gtgtagcatt tattactttt gcaacattta acatagtctt 117060 taggttattt gattatgga ctacagagaa gaaaatggta agtcaaggac aacccccact 117120 aagtaacttt gagtactatc atgtgatagt accttaactta gtaggagtaa ttgttattat 117180 actaagtatt atttttagag attacctata ttctgcacag tcaggatttg gtgttattat 117240 tacaagtttt atttatatgc tagtttatgt tataattggt cttgtagggt catttatact 117300 tacaatattc caagctagaa aagctagaca gtaccacaca caggaggata ataatgaagt 117360 tcaatgatat ttatgagcaa ttgattaaaa atgatacagt acagaacatt catgaatctc 117420 aagatgataa aggaaatatt tataccattc aatttgacaa gggtaacgat aagtatttat 117480 ttaatgtcat caatgatgga ttcctaaaag aaatgacagg cggtatggta gaccatcctg 117540 aaggtcagcc atactcagta agtttaatta ataaagaaac acctagtatg tcagtgaaac 117600 aatatttaac agaagtagaa gatattgtac ctactattag aaaaatggaa aaggatttct 117660 tatagagtca agtctttact tgactctttt tactatatat ggtatattaa tatagaggtg 117720 acttaaaaat ggattttaat tttagtgctt ttgatgatag ttcattagca atgagaatca 117780 gtgagggtgt atactatttc aatgatactc cttactactt tattgagcat gtagaggaag 117840 aactatcaga gtatgttatt gtgtatgata tacatgatag agaggaaaaa gaaaatcctc 117900 agaagaaata tagaatagag tcttatcaac ggacaatacc tggaggaaca cctcttagta 117960 atttaattaa gagtatgatg cctcaacgta aataccctaa gaaggttgta gacgacccta 118020 tatttgtggc taatattatt cctttagggg tagatacaat aacaggtaaa acaggtaaag 118080 ggttctttga aagagataga gatagaacta tttactcaga gaaagaacca actaaggtag 118140 ttcatggtca atatacaggt gtttttatag gtctagcaaa tgttaaatgg aatagaactt 118200 acactccttt agaaagtgtt gtagagtatt gcaagagagt aaaaggagat agattaaatg 118260 tctaatgatg tagttaagtt ctatgaaaaa gatattaaag accttataag aactaaaaaa 118320 cacatgttta aagatgatga aataactagt gatataaatg atatacgtat ctttaatgag 118380 aaagtaattt gccaaggtaa gtgtagaaca gattgcttag tgttagaccg taatggtact 118440 gtcatgggta tagaaataaa gactgagaga gattctactc aaaggctaaa caaccaacta 118500 aagtattata gcttagtatg taagtatgta tatgtaatgt gccacgataa gcatgtacct 118560 aaagtagagc aaatactaaa gagatataaa catactcatg taggtattat gagctatatc 118620 agttttaaag gtaaacctgt tgtaggtaaa tataaagatg ctacaccatc accacacaga 118680 agcccttacc atacaatgaa catattatgg aagactaacc ttatgacaat acttagactg 118740 attagagacc ctcatacgta cagaacaggg tatagttata atgctagtgg tagatatagt 118800 ggaggtgaag gtaacttctc tcaaacaacg cagagtaaaa gaatgaagaa acctgctatt 118860 attaatcaaa taatacacta tgtaggggta gataatacct ataaactctt tacaagaggc 118920 gttatttatg gttataataa taggtgggag gtaatagaag aggatttctt taatactatg 118980 aagaatgggg taagagtaat caatgagcaa agacaaacca aatagacgta aagagataca 119040 acatcaacct gttaactttg cccctacaaa tactttaaca ggagctaata atagtttctt 119100 agctaaaaag ccttcagaac ctaaagatac aacatctgtt attgagtata gaatactttt 119160 tattaaaaga tttgataacg taactaatac tgatgttaag ctacagaaaa aatatgcatt 119220 aaaccttatt agtgaagcac ttgatgttaa agaaacttat ctatctctta agcaaaaagg 119280 aaagaaaaca gaatctatac tccatacaga ccgagtttat tatgttcata gaggtaagaa 119340 acttattggg aagtgtagta tccgagagca aagaactttt agaggtaaac atttaatatt 119400 tatatttaag acaagacata gagttaaagc agaaaggaaa gataaataat gttaaaagga 119460 ttttcagaac atgtagataa acctacaacc attaagacct tatataagac actaacaagc 119520 ggtaaagtag aattactagg ggtatcttat gatagtgatt acttcccttc aggtgttaca 119580 gtacaatcct acattgaaga tatagataat gtagatgaag gtcttcagtt tgttaataaa 119640 gtaaatgtag tggaatcaat gaaacaagct gtagtaggaa tgaataatca attaggttct 119700 tcaggtcttg ggtatgttag aactgaacaa cttaaaaaag aactagaaga aacaggatta 119760 atgacagatt tactttctag aggtactaac ttaacttcta ctaagaaagt agatattgta 119820 agtacattca tagaacctac tgtaacttac caagatatta caatagctaa agatattaaa 119880 ttacgtttat ataaattaga agaggaatca ccattaaatg gttatactca tattgtatat 119940 cttcttacta cagaaaaatt atatgatggt caaacactat ttggtatgtt atctaagaaa 120000 gataagttat ctaaaggtga tacagaaaag ctactagctt tcttcagaaa taatagttta 120060 ataagtaaaa gtgtattccg tgttaagtta ttaagtagag actatcactt taatttgtat 120120 aatacacatg agacaggtat attcttttta gaagatacag atattattac tattgcttgt 120180 ggtcagtcat atgttaaagt taacactaaa gacattaagt ctagtcatgt taaaattgaa 120240 aatgatacta agaaattaac tgagataata attaacttaa aaggtgaaga tacattaacg 120300 attttattat aaatatgtag taattaggta taaatatacg ttatataaga agttttcata 120360 atgtttttaa tacagaaact agttaggttt tttctactta ctctagtttc tgtgaaatta 120420 tattatgaa aagttaaaat atcttttagg taaaggcttt gtaattagtt aaaaaatata 120480 ctaaaatttt atacaaagta gttaataaaa ttatattaca tttatatatt atgaaataat 120540 aacagaaatt gtgatatatt atatagtgta accttgaaac agttgatgtg gtaagggttt 120600 gtttatgttc attaacctgg tttcagaaaa ccagttacca taaataaatg acagttaagg 120660 agagctatat aatggctaga aaaaagaatt taagaaataa aaacagtaat ataaaagttg 120720 ttcccgataa agaaaaagaa agtatattat ctaagttata tcacaataaa ttactacgct 120780 caaaggtaga taatgcatta gatgaggata tgagttatga tgatattata gaactctgta 120840 aagaatatga tttagaattg tctaaatcag ctattacaag atacaaaagt aaaagaaaag 120900 aagctattga aaatggttgg gatttaggag aattaattga taaacgtaaa aaaacaagtg 120960 taaaagatat taaggaaaaa gaaactccta tattagaaga ggagcaactt tctccatttg 121020 agcaatcaaa acatcataca caaacaattt atgatgatat acaagtacta gatatgatta 121080 tatctaaagg tgcaaaagga ttagaatttg tggaaacttt agaccctgct ttaatgatac 121140 gtgcaatgga aacaaaagat aaaatcacag gcaatcagtt aaaaggtatg tcatttattg 121200 ggcttagaga gctacaatta aaacagacag ctcaagacac agctatgagt gaggtattat 121260 tggaatttat acctgaagag aaacatgaag aagtattaca acgattagaa gaactacaaa 121320 atgaattcta caaaaatcta gatttagatg aagaaagtag aaaattaaaa gaagctcttg 121380 acagagtagg ctatacaatt tagatagtga ggttagagta atggcagaag agattagttt 121440 aaatccaata caagatgcta agccaattga agatatagta gatatcatga catatttaaa 121500 agacggaaaa gtgctgagag ttaaacaaga caaccaagga gatatcctta tcagaatgag 121560 cccggataga cataagttta ctgaagtatc tagggattta gataaagagt ctaccttcta 121620 taaaagatat tgggtattat ggaatatatc tattaactct cttataacat ttgatgttta 121680 cctagatgaa gaatattcag aaacaactaa ggttaagtat cctaaagata cgattgtaga 121740 atatacaaga gaagaccaag aaaaagatgt tgctatgatt aaagaaatac ttacagataa 121800 caatggtaat tatttctatg cacttacagg agaaacaatg ctctttgatg aaaataaatt 121860 aaataaaatt aaagattaag gttgacagtt cttaaagtat atgatatagt atatgtatac 121920 taaaaataaa ggagctaaca attatgttta tttcattaaa tcaagaagag aaagcattat 121980 taactaaaga ggaaagcaag tacacaccgt tagaaacatc aagagagttt aacacaccta 122040 aggaagaatt cattgtaaca agttataacg aaggtaaacc tttagattat attgcaaaag 122100 aagctaaagt aagtatggga ttaatttaca cagtattaaa ctactataaa gtaggtaaac 122160 gtaacaagaa atcacctgta gaagaaaaaa ttgcacacat cttaaaggat aaagacttag 122220 ttaaagagat tattaaggat taccagtata tgaatttaca ggacatttac agtaagtata 122280 atcttcataa gaatggttta tattacatct tagatttata ccatgtagaa agaaaatctg 122340 aacttaagga caaagcgtta gaagaagata ctattgtcgt tgagtaagta aagaggttat 122400 aatatgagaa ataaaaaatc atttcaagaa cagttaaatg acatgcgtaa taaagagaaa 122460 tgggtatctg aagaggagtt cactgaagaa gtgactcctt ctgaggaacc tgaagtagaa 122520 gaagaaaaac tatacacttt agatgagcta aaagaaaact tattagatgc tcaaggatta 122580 aaagatgttg tagataattt tcctgcatct aaaccactat atgaggctaa taagctttat 122640 atctgcacaa taccaaaagg ttatcgttct aaagaagtac aaccaggtca atacattggt 122700 atcagtacag gattattatc agagtcagaa gaatttgacc atttaagagg tcaaatgcct 122760 agaaatcttt atgaaacttc tcatgtttta aaacctttag tccgtattaa taatacaagt 122820 atcgaatatc aacagcatga gttacttgaa gatattaaag aagacaagaa tgtatatgat 122880 gttgaattag aagacttgag attagtaaca ggagaagaaa tttctcattt agagattgtt 122940 gatagtaagt tttttgaaag acgtattaat gaagtccttg acttttatca tgaattaacg 123000 gattccgata atttaattga gtattatagc aaattacgag agttagttgg aaatgataga 123060 atgatttact gctcactcct agataaacgt gttaaaatta tagaatagta actggtctcc 123120 tcttatatta gaactgtaag aggagacatt tttgtataga ggtgttagtt atgtcaaaaa 123180 aagcaagtat attttatgta ctagtggtta ttgttttggc tttttctatc tcatcttatt 123240 atatatcgtc tttcatgtat cacgacaaag caaaaagtca agttgctacc caattaacaa 123300 atacaggaga aattaaaggt gaagagaacg ttgagtttgt cggtgactat acattgaaag 123360 aggttaagaa taataaagct tattttatgg aaacattacc tacttacctt ccaggtagaa 123420 caggggataa cagcatagat atgaggtact acaaaacaag tagatttaaa gagggagtaa 123480 gttttaagct tattagagta tatactgaag atggagacga taacccagtt cataagtata 123540 ggtttgaggc agtaccaacc gaaaagtaat aaggaggtgc cttaaatgac agtacttatt 123600 gttgtcatct ttattgctat catttattac ttatggaaca gtgattgagt caagttaatt 123660 cttgactctc tttttgtttt atggtatatt aatatatagg aaggagagat tagatatgga 123720 aatggtagat ttagaaagat ttgatgcatt tgtaagacta atttcagatg atgagctttc 123780 ggaggaaaga atactagagt taagcgtaga tttactaaat ccgatactag aaggaggtac 123840 agcttacaaa gctaaaaaac gtattcgaag taaatttggt aagttagaag caaaaaactt 123900 taaaagaaat tataagttct tacttaagtc gatagctcaa atagaccaaa ggagatagaa 123960 caatgacaga aagggaaaaa ttagttaaag atattgatga ggctaacaga gatattcaaa 124020 ttaggctaaa agaagtagac gattataagg atattatacg ctctaaggga acacgtaatt 124080 atgtatctac aaaagtatta gattcagtta tggtaggact aattataagt ttctttattc 124140 ttataatcct acgtgttatt gagtattttg taacaggtaa tgctgtttac tcacctttag 124200 cacctgcagt tattattatg tttgttttag cactaggaac ttggaaagta agtaagatga 124260 ataaaatagt atcctacaga ggaagtataa agatgtattg ggaactaagt aatgctgaac 124320 agaaccaggc tgagatattt aagtatccgg atgatgaagt agatatagta gcaaagcata 124380 agttgagaca aattactttc agtgagataa atatacttca ctttaaatat atgaagtata 124440 ataaagcagt agagaaccac actaaactat ctaaagaact ttttaaaaaa gataaggaaa 124500 ctgttgacaa gaacaaataa gtgtagtata gtattactaa aggaggagag atattatggt 124560 tatacctagt attaaagcac aaaacaaatt caagaatgag ttagagtatt ataagcaagg 124620 tcacattagt gaaagtaaaa tgttagaatt agcttttgat tacatccaag aattagaaca 124680 aaataatgaa tacgttacta atttactaga agaggagaga tatggtgagt aaatttatcg 124740 gagtgtactt atttaattta ttagtagtaa cattaattta tacagtaggg tttttattct 124800 tttacggagt agctagttta gttattctta taactcatgc tacgattgac ccgtttgtat 124860 tagctacttt cttaggaata ggattcttga ttatcagaac agcacataga attatgatac 124920 gagtagtaaa tgacgcagta gcccaagcca ttaaggataa agaaaatgaa taaaggggaa 124980 tttattatgg ataaatcatt accaaagttt agtgtatatg aagttattgt aaagactgta 125040 attatgacac ctacagaagg aagttctaac cgagaatcat tttacttttc aacccgacag 125100 ttagcagaaa gatttgttaa ggaaaatcaa gtagaaacaa aggatggaaa acgtgtatct 125160 ttttctatta aagaacgtaa cgtaaatcaa ccaggctaac attaatttgt tagctttttt 125220 tattgacaaa tcgttttata tagtgtatag taatattata cagaaaagga ggaattatta 125280 tgaaagtttc agaagaagta aaacaaagtt acttagagaa taaatctaat actaaaatgg 125340 ataagataag ttggtctgag ttaaggtcta gtcctgcagg tagaacatta ggagaattaa 125400 tataccttag tgtagtcgta ataaataata tcatagctat aggattaaca ttaactctag 125460 gagacattat caaagactca attgatagta ctttaataaa aataataagt atattactta 125520 ttattatcgt tgtatacggt atactatcgg ctttaatacc tatactcata tttaaatctg 125580 tatttcctgg ttgggaatat actgaatgga ataattctta ttatttgaga ttacctggag 125640 aaaaagatta taagtactat agctactggt atttaaattt attaggtgtt actgagtttt 125700 atcggacaaa tgatgaaggt aaagaaatta aagaaactag tttaagttgg gttttttata 125760 ctaaggttga tagacctgag gatattaacc attggaaaaa tcaattaata actaacagac 125820 ccttaacaat ttccgagtac aaaaaactaa agaaactaga taaagaaagt gaaattagga 125880 agcaagaaga tttagaagag tatcaaagat acaataattt ataggaggtg agaaaccaat 125940 gataagttca tttgatagtg tattacttgt agtatacatt attatagctt ttgcagtagc 126000 tatggggata ctttatttag tatttaaagg tatgtctatt ctactagata aagtgatgat 126060 gttattatta agtaaaacta ctttagatgt agaagtctgc tctatgatag tagcagtcat 126120 cagtacaatt gtgtttggaa ttatcatact tttagtatgg ttagtagtaa acaatatttt 126180 attgtaagga gttttactat ggattttaat gactttataa acagtgagtc agatagagta 126240 ggtaaaccta aacaaaaaaa gaaggtagaa aaacaactac cttcttctac tcctatcgaa 126300 gaaaaggaac aaatgttgaa aagaataaga gagaaatcat tatatattga tttaaggaga 126360 aaaagaaatg actagagaat atctatataa tactggtgat atagttaatg atagtttacg 126420 tataatggaa aaatcaagaa atattaaaag tggtaaaaaa tcatatatag tgagtagtat 126480 aaaataccct aaagcccctc attatagtat attagaagag agtatagtta atgggcaaag 126540 agatgcttac ttaagtggta ggagaatatt tgagggtaac tccttataca gcgtagaatg 126600 gattagaccc tatttagtag atattgatgg ggctaaacat atagctccaa atagcactaa 126660 gaaaatagaa tttaaatgcc ctaattgtaa tagagttaaa gaagctaaac caaacaatat 126720 tataaatcaa ggtttttcat gtaacttttg tagtagtaat atcagttatc ctgagttatt 126780 tatgatggca tatttagaag taaagggtat taactatgaa tatcagaaag tatttaaaga 126840 tttaccaaat agaagatttg atttctactt acctgaatct aatactatta tcgaaacaca 126900 cggtattcaa cactatgata aaaaatcaac atggttcagc caagcaaaaa tacaggatga 126960 agaaaaaaaa ttatggtgtg gtaagaataa tattttatta gtagaaattg attgtaggaa 127020 gtcaagttac atgtatatta aaaaatctat taataattct accctgccta acataaggaa 127080 tacagaagat aaagatattc aaagttatgt agagtattta aactataata acttaaaaga 127140 aatagtgggg ttatatgaag aaacaggtag tatggaaaaa gtaggtaaaa aactagggat 127200 aagtaaaaca gcagtaagaa atacacttca acgaatcagt tataaaaaag aaagagggtt 127260 tgaagattct ctagttattg agttatataa aaagtactat tctatgaatg aggtagctaa 127320 agaaacaggt atcagtacag ctacagtgtc aagaatttta gaaaacgaag gtattaaaag 127380 aataggtaca aaaaagaaca caaaaaaagt attatgtgtt acaacaaata cagtttattc 127440 aagtacctct gaagctagta aagaaactgg gataaatatt ggtagtatat ctaaagcttg 127500 taataataaa attaaatacg caggtaaaat aaacgaacag cctgtgtatt ggaagtatat 127560 aaattaattt aaaaaacttt acattaaagg cttgacagat gaatcatttt aatgtatagt 127620 aagagtataa ataaaaaaaa gaaaagagga atgattatta tgttattagg aattttatgg 127680 tttatatggg gatttgtatc ttactttgtg gttatgcttg gtgttgagtt ttataaagat 127740 agatggatgc caggagttat tggggcggga gcagtgttac tatttatgtt ttgggttatg 127800 aaatctatcc ataacgctat gacagtagta tacttatact aaaggaggga tactagatga 127860 atatattagt tatccattat gaagaaacaa ataaacgagt tctaaaagaa acaataaaaa 127920 caatacaaaa tcatttaaat gatgaacatg atttggttaa aatgacagca acaagactta 127980 atagaaaagc catagaagaa gagtttaatg attacaatat agttattgca gagaatgacc 128040 ctgatatttt ttatggctat gcagatgcag tagaagaagc ggattttatt atagatatac 128100 caatttcata tttagatata catgcaggtg tagagtggga tgtcgataat cctgtagata 128160 tgttagatag aaaccctgat tttatagagg ctatgggtaa attaaatgag gacttaatgt 128220 tataaggagg aaataaaatg ttaaatgaaa agctaaaaaa cttagaagat tcaaaagtat 128280 atttgattaa tggtattgca agcctactaa attcaagtac aggtaacttg agtaaggtat 128340 tctttgatga aggtgatatt aaaattgtaa gtggtgatat aaaagcagta gaagttattg 128400 ataacttagt tcacccgcac tcaggacgtt tacctattaa aacaacagaa cgtattgctc 128460 ttggtagatt aacagattct ttacagtttg ttatttcaga aatagaagtt actaaggata 128520 aaattataga tgaagaaaat gaatcttaca ttgattttat gatggaagat tgggattggg 128580 attaacgcct atggacttaa tgacagtagc ttctattgcc tttatagctg tcgttattat 128640 tgatttactc aatgatgaca tgagctatat attggcaggt attgcaatac taataaacat 128700 ttgggcaggt ttttatgaat ggttcttttt actacaagca ggtatgctac ttttcttact 128760 cttagctaga aagggtgaag atgctaagga atctatagta tactcaggtg cttcagtact 128820 atgcgtattg ggtatgatag taaatctttt tgtattttct taaaaataag tattgacact 128880 tctaaacttt tgtattatac tataagtata ccaagtacag gagatgatta atatgagtaa 128940 agaaacaatc agaagacaat tttcaaatgc aattgagatt atggcaacaa ctaaggaatg 129000 gtggaatttc cctaaaagtt ttaatacaaa taaagagttt aaaattaaat cttttaaaaa 129060 tgacacacta gtatttgaag ttagagaagg taatagaaat ttaggaagct ttgtagtttt 129120 cacatgtatt gactttgatt atgataaact tgaaggaact tcaacacaat acatgattaa 129180 ttactttgct aagaaggtag ttcgtgacat gttttcattt tacagattac aatcaaaaat 129240 gtaaaaaaac taaagggtgg tatatatgag catatataat tatcaaatag gggagatagt 129300 aaataacagc aatgaatttt ataaaaaata aagtatttta actaggaggt gaaattatga 129360 gagacgaatt aaagcaattc aatagaagaa aagtgaatgt ttgtggttat ttagatgatg 129420 ttaggtactc aaagcgtaga aggcataaag gtaatcagca tggatgtgta aaaataacag 129480 ttactgatgt aacaattaat ggtatagcta ttgaccatgt taatattgaa gtaggtatat 129540 aattttatga aaaacttaaa gagttacaag gtaaaagaat tcaatttgta ggcactgttt 129600 acaagtatgt taaacatgct agagggtata aaggtaaaat taaaggattt tataaagagg 129660 attatagtgt aactttagat aagaagttac aaaaggagga aaaataatgg taaaaattaa 129720 aactaagaaa aagctaaacc ttcctcaact aatagaatat gcatgggata acggtattac 129780 aaacaaagaa tatatttgtg atggctttga aattaaatca gtcgttttta atttatcggg 129840 ttgggcagaa tttagtgatg aattttcata taatccacac gacactttca cagttgaagt 129900 cgaggaagaa ttaacggaag atacagaaat acctaaaatg ttggtcatag gtaggtttga 129960 tggatacgag gaagtgtaca atcaaaaact aagctctttt aatcaacatt tactaagtgc 130020 tacttaatt cacgatgatg gatatatgga gttaatatat gacgaagtta aagggttggt 130080 ggagtagatg tctgaatggt atgctttatg ttattatgat aaagtaggta aaaagaagaa 130140 acctaagcaa attagagcac atagagatat ttcagtatta gaggaactaa aagagagact 130200 agaagaaaga aaccctgaca cagagtacgc tataaaaaca acaaaagagt ttgataaaat 130260 tagagagaag ctgtaattat atggtaaaat attattataa caaatatatc taactgttgt 130320 aatgggaaaa taaaaacagc aggtaaaatg gaatgggagt atatttaatg ataaggagag 130380 ataggaatgc tgacaccgga acaatggact acgttaaaag agcaacaaaa aaaactaagt 130440 aaaaagaaga aataactgtt gacaaaggag tgtacatagg ttatacttaa gttaataaat 130500 aaagaggggg tatgacctat gttattcgta atttttattc tagcagtatt atttgtatta 130560 ggttttatta acggttataa ttcagaggat taaaaaaaag gagaggttat aatgaagtta 130620 gaggataaag tgttagatag aattgattcc cttgggggta aattagacaa tattagtcag 130680 cacgcatggg aagccctagt aaagtatcaa gttatgtatg gtattataga ccttatcgta 130740 ggtattgtag ttatagcatt aactatactt ctatggaaga tatttatta ccaacataaa 130800 aaggtaagaa gtgaatatga tgaacatagt ttactattta aatgtcgtgg ggatttaaca 130860 ggtataggtt ttacctatat aatagctacc tcattcatat cactatttgc acttatttat 130920 ttagtatacg gaatacctat ggatattcta aaaatactaa accctgaagt atttgcagta 130980 aaagatttaa tcgaacaagc taaaggagga aattaatatg aaacaaagag attttgaatt 131040 tgaagaggat tttgttctag cttatgaatg tgtggattgt aaacatttcg aagattgggg 131100 ttatgatgaa gagcctgaag aatgtagtga gtgtgggagt agtgatttaa ttaataatac 131160 aagtcatgaa aacactgagt gtgacatgtg taaagggtac attgatatgt ggcaagatgg 131220 atatagatac atgggagata ataaagaata tattgaaaaa gaagatcag gtttaatttg 131280 tgaagattgt tatgagaaat tagatattta ataaggagga atttatatgc cagtaacggt 131340 acctcatgtt cctgttgtaa gtaatccaac aactactagc cctactacca ctacaagtgg 131400 taatacagaa actagagaag aaacgatagc acacaattgg gaacctgact taatatcaga 131460 tactgaagct atgtacatta ctatagctgt tgttttaatg gctattatag catgtattgg 131520 cttatggatt tatgctaaaa aatttttaaa taaataggag gaaaagaaga aaatgaataa 131580 cagacaaaag aaaattttaa cattaacggt aaataacttt ttaattctag ggttagacat 131640 tatagcttta attaggtata aaaaaggtaa aactaaacaa gagaattaca atgtaggaca 131700 gattactagg gtaatatcta caacagctaa ctcattaggt attctttatt tagaagaaca 131760 agaacgtaaa gagaaggaat ctgttaaagt agatacctct aaaagcggtg ctttgggagg 131820 atttaaaaat aaataggagg tttaataaaa aatgagtatt gaattaaaaa aatgggaaga 131880 aattattaat aaacaagaag aaattggtgg gtgccctaaa aaggctaagt tatcctttac 131940 aggtaataaa gactgccaat cattcaaaga tagccttact gatgaagaag gaattatatt 132000 ctacgtacaa aatgaaaaac tagaagtagt tagttcaatt gttgttttag ctaatggtga 132060 gactgttgtt acaactgaca gtaaagtaac tcatgatatt atacctgatg attttgaaac 132120 ttcggaagag tctgttgtgg agtttttaga taatttatat atgaaagcta cagaagagta 132180 ttataactgg ttacaactac aattagttgg tactcagcag gaagacaaat taccaggagt 132240 cattgcagaa ttatcaagag gtcttagagt aggtagtttt actatcaatg accgaaatat 132300 actcattcaa agaagaaaag taagtataca tttacctgag ggatacttaa ttgttattga 132360 atactctaag gatgaaggta gacatattat agatactaaa ttgcaagatt ctgaaggtac 132420 gcttattaac cgtattatta aaacagatat tacgtatgat ggtttaggtc atttaactaa 132480 taccttagag agtattgtag aaccaatttc attataaaaa aagtttaaga aacctattga 132540 cagtaggttt cttttattat atactgagag tataagaaat aaggaggtta acttatgaaa 132600 gggattatta tattttataa agaagaaaat aaacacatcc taaaggagct tttagaattc 132660 attaacacaa cagcaaaagg gctatcttat actacagaag gtacactagt cgataacgat 132720 atcgttttac ttgaagataa tagcatgagt gaatataacc taagacagtt tagtgagatg 132780 aatagtagtt tagttatagg attactaagt aaatcatata atgatgttca ctactatgaa 132840 aaaggggatg cctatggtat aagcatctta gatgattatt tagaggagat gagtcaataa 132900 tgttagcaat atttgcatta atttttggtt tactatttat tttatcttta ttaggtattt 132960 ttatttattc tatagtttta cgaaagaaaa aacaattaat agaggaacga gaatcttttg 133020 gtattcagga accagggaga caggtaggtc atacaggtta tgttgaaagt aaatatgctt 133080 taattcataa agaatcaaat aaaataataa taagtgcaag taaaagtaca gttatagata 133140 cattacaaaa aatgtataat ttagaattaa catctgtaaa cgtttctgat gtgaaaggtt 133200 taactccttt cggaggtcat atagagaaca tgatattact ttcatacaaa ttagatagag 133260 aagggctcta taaattaatt gagcttaata aggaggaata aagatgaata tactagcatg 133320 taccaagaag aaattgaaaa taagtgttga caactgtaag atagtatgat atagttatga 133380 tatagtatag aaaaggagga agtagaaatg gtaagatacg aaccaaatct taacggagaa 133440 aattatattg caacaccatc acaagcttta agagaggcac tatccgaact aatatctgca 133500 gaaaaggatt ttgcagaata tcaaactaaa ggtgaggaac aatatgaatc acagttacaa 133560 ctaagacact tcgattcaat gatttctcag tatgaagagg ctattcgagt actagaggat 133620 aagtattcac ctcagatttt tattccaaaa gataataagg aggaaaagta attatgaaag 133680 caaagtcaat agaacggttt tttcaagaca aggtattaca aatagagggg tataaagtac 133740 ggttttcaca agctagttcg acatatattt tagacataga tatgatagat gaatcagtat 133800 tgtttttaga tactgtagtt ttcaccttat caggtaagta cttattagat acacagatta 133860 cgattagtaa acctgaaaca ctaagcccta ctgaattata cacagagatt agtaatactt 133920 tacaagatat tgtaggagac caaactaaaa cagatataga gttatcaaga tactttaagg 133980 aggtaaaata aatgaaatca gatgctatta taaattcatt attaaatatg gaatatatag 134040 atatacaaaa acacaatata aaagtaactc ttgagaaggg tagatataag ggcgtagggc 134100 atttcataga atttgaaacc tcaatacaat acagggggaa ttataaatta cagcctgcaa 134160 taactatatc ttacgaaaat gaagagccta aggaaatcct tactcaaatt agagataaag 134220 tattgaaaat tgtagaagag cagataaaga cagatgatgt atttattgaa gcaattgagg 134280 agattaataa ggagacagct cttagaaaac tgaagcccta tattaatgaa gaatactact 134340 cagtgtttaa atcatctatt gataagggag tacctgtagt tttaccttct gaacttttag 134400 atagatgcac aggaaaaaca tcaacaatgg cttatttagc tgtagaatat gatttacctc 134460 tcgtagtatc aaacacagtg aaggttagaa tgttattgaa tgactatccg aatattaaag 134520 tcacatcaaa aaaacgagaa ggctataacg attcaatagt gttagttgat gaacctgacc 134580 ctaagatact aaatctttac tagatgcac ctgaatgtga tattattggt attactaaaa 134640 attaaataaa tttataaata cctgttgaca gcaggtattt attatagtat actttagata 134700 taaagaaaaa ggagaggtta acatgaatta taaagaggta ctagaaacta ttaaaaagag 134760 caaaccatgt aaggttagat ttactggaag tattgtagca attgtaaatg aggaatttaa 134820 tgcagacact ggtaaaggtg tattacagat tgatgtatca gatatcaata gagacgatta 134880 cattaagcta caacagtatt gtttagaaag agatgattat actgtagcag gtgctatttt 134940 attttaagga ggtagtacta tgacaagtat tataatttta attgtaggtt taatattatt 135000 tttagctagt ggatacaaat tagttttagg taactattat gatactgcag atttaaaaat 135060 gttatttaca atatttggta ttggtgttat actattactt gtaggattta tattatagag 135120 agtatattaa atagttgaca ttaaataagt aatgtactaa gattaatata taatcaacta 135180 ggaggagata ttatggaaga aaaaatcaaa gatgtgttat catttatcct tttcaatata 135240 tttataacgg tattaggata tataattttt acaatttaaa acatagattt tattacagta 135300 attataaaag aaaggtagat aaacatggga ttagacttta ttatagaagg tgtaacgtta 135360 agtaaaagaa aagtagaaca agaaggttta caacatttca taaatgacaa tagatattat 135420 agttatatag ataaaaacca tgagttaaac tttgaagcat ctttcagaaa acctgatgaa 135480 tttatgggta tcttagtgca aaacgcaacc aagtatttcg atgaaaatta cgaatatgac 135540 gaaggtaaat atgttttaac acagaatcag ttagtaaaat tgattgacaa tagctttaat 135600 gaagaaatgt ttaaatatac tgacgatgaa gaaaattatt atcactttat gtcaatggtg 135660 tgtgatgtaa gaaaatataa tagtaaattt tatgattttt atttgattat gagaataagt 135720 gtttgatgaa ttaatagaga ttttataagg aggaggaatt attatgaaca ctagacaaat 135780 tattaaagag gttaaacaag gcacagcaga gtacaaagtg gatgagattt cggtgacaga 135840 cctacaaaat gctaaatact atttagaaga tgaaaagtta tctatagtag gagaatttgg 135900 aatctatgag ggtttattac atgagcaaat tactcaaggt attcaatggt attatgatac 135960 agaatgtata ggttatttgg acttagcaag aaatatatta tttgttttaa tagagcaata 136020 cattaatgaa gggtatttaa aataaccgtt ttataggagg aggagttata atgtatagat 136080 atttatattatt tagttatgaa ggttactacc ctaatggagg cataggagat ttaaaaatta 136140 gttttaatac tatcgaagaa ctagaatatg ggtattccgg tgaacctttc ggattatgtg 136200 aatacattga tgtatttgac actaagacag gtagaactgt aaacaaaagt gattacttcc 136260 ctgaagtagt tgaagaagta aaagagtatt taaaaaataa ttaaataaaa aactttaacc 136320 ctagctattg acttagctgg ggttttgtta tatacttata tcaagaagtt aaaacaaata 136380 caaattttat tggaggtttt aatatgatag taacatatat ttttctagtt tgtttatatt 136440 ttgttcctgt atcgtgttta gtttatttat tggtaaatat aatacgagat gattaaaat 136500 aaccatttta aactgttgac aacgaataag aagtatagta taatagtaat ataaacaaat 136560 aggaggaatt atatatgaga aacgcagaag aaattagaga agagcttgac gatatttaca 136620 gagtattaag acgcagtgag gatatttcag acatgtttaa actagacaaa aagtataaaa 136680 gagaactaga aaataaacaa ggcagattac aaaaagaaat aaatgaaatc aatcgtataa 136740 atggtactga atattaagga ggaggagtta ttatgagtaa catatttgtt agagaagaat 136800 ttattgaccg tttagaacaa gaaggattgg aagtagttga ggaagatggg tattatacag 136860 tagaagatgt agaaggtcat gttattacta tagagtttaa agatgataca gtattattactca 136920 tggataatga agtaacagag acagcctaca acgttaacca aatctattta gctttctatg 136980 cagtattaga tgcgttagat tatgaatttg atgaataata aaagaatcat tttataggag 137040 gattggtaat tatggcatat gtaacacata ggcagattga ttacatagtc tacttgcaca 137100 agatacttgc agaatttggt tatgtagact ttgagtttaa aacctattca gaatatagta 137160 aactaagcac taaacaagca ggtgtatata ttaggaaact agaaaatgaa atgactccta 137220 atgtatatga tgctatggaa gagaaagcgt gtttagaaga agtgtatggt ataggacaag 137280 aataaaagga atcattttat aggaggaaat tatgataaac ataaaacatg attatacaat 137340 aagaactgtt gataatagaa aatactcata tggaaatagt tacaagtcgt taggttctgt 137400 atacagagat gttatgggta atgattatat agaagtaact aaatggggta aagataaaaa 137460 ggttattatt gatactagac atattgtatc tattgaacga tggtaaataa caagaatgaa 137520 tagaaagtat gttaaggtta gtatataaaa tataaggggg aagtaaatat gtacaaagaa 137580 gtaatagagt taattaaaga aagaattagt tattataatc ataaggaggt aagtttctca 137640 ttattttata ctcaccatga tgactacgca ttaaacataa gaagtaatat acatgaagaa 137700 gaatcagtta tatactcaat agatttatgt attatggatg tagcatcctt ccatttagct 137760 attagaaaag acagagaaga aaaaggtaag attagattag taacggataa gtataatgat 137820 tgtaagtaag gtagttatgg ttattaactta atagatagga atacacttga tacttacata 137880 gtggataggg aagaacttat agattatacc actcagtata ttatagaagg gaataaggtt 137940 aatattaact tagtatagta tataaggtaa gtataagaga taatagaaga agagaaaatg 138000 aggaggaatt actatgaaat caataagaga agaaatgaaa gatagaattg ataaacttac 138060 tatagaagag ctaaacgaga tttatgagag tgtagagtta ctacaagata atgattattg 138120 gaataaagaa tagatgaaa ccgaagagga aattgcgtta attaaggaga agtacaaaga 138180 tagaggtcta aaaggcttag aaattgtaaa agaagaacaa gctatttctt atgctcaaga 138240 ttctattaat aacctctatg attaaataga aaaattaatt tagaaaaaaa gtgttgacaa 138300 ataattaagt gtgtgataca ctaaatatat aacaaataaa aggagatttt aattatgaaa 138360 acaattttaa aagtagttat cggtattatt ggggcattta ttattatggg aatgttattt 138420 gcaggatgta cagcgtttgt atttaacgaa gcagataagg aaattactaa acaagataag 138480 aaagataaag aagaggctaa gaaagaatac cctgtaggaa caacgaaaac ctatgaagat 138540 gtagatgtaa cagtagacag tgtagagcaa gtaggagctc ctgaaatggc ttcacaagaa 138600 ggtacatttt ataaagtagc atttacgatt aaaaataata gtgatgaaga tgcaatgttc 138660 tcaacaagtg attttaaaat gcaatcagaa ggaaaacaat ttgatgaatc tatggatttc 138720 ccggatgctt tcgatttaga tagcattaac ccaggtaacg aagtgacagg aaatgcctac 138780 tttgttgaca cgaaaggtac aacagaaaaa ccacaagtac aattgtcatt ctcaccattt 138840 atgattaata cacataaagt taattttaaa taaaattaaa aaactttaac tctatctatt 138900 gacttaggta gagttttact atataataag agtatactaa ataaggagat gatttgtaat 138960 gtcactaaaa ctaagtaaag aatttaaaaa attattaagt agaaaaaaag caagtaactg 139020 tgagagaatt gtaggagcat tattagaatt gaataatgta gaatttcaaa tagaaagaac 139080 ttttaatgat ttacctagga agaggtttga tttttatcta cctaaaacaa atactttaat 139140 tgaggtacat ggggagcaac attataaaca atcaagtatt tttggtagtt tagaggatat 139200 taaagaaagt gatagaataa aaaaagaata cgctaaagag aatggtatta cctatataga 139260 gatacctgct aaacgttcag agattcctac tataagaaac agtataaaac agacaaaatt 139320 aaattattta ctagaaaaca tagatgaaca tacatggaaa gattattcta ttcttaggga 139380 aggtaaaact aagttacctt ctgtagaagt actagatatt attaataatc taaggaatga 139440 taatataact gaggatactt attcagagga ggaggaagaa gcattatata tagataggtt 139500 aaataaagtt agtataccgg gtgaagtaaa gtgccttact actaaaaagt tatttactga 139560 tatacaagat gcttgtaact attataatat agagtattca gaactcaaag aaggtgctac 139620 ctattataaa catgaaggca agatgattat actgagtaaa gtgtaaggaa gaaaccaacc 139680 aataagaata accaagaaag aaaccaataa gaataaccta atcaagtaaa tacctaggag 139740 cctgggaaaa cttttacctc tcccattcgt tcaatcattc actaccgact ttcctaaata 139800 cttattatat agttatacta ttcatttatt atacaatagc taaactatag tattccgacc 139860 ttaatctatg ctgaagcggt agtaatctat tgttattata taataaactt atctaatggt 139920 acactaatct ataataaaag aaagtattga caatagtaac cgcttctagt agaatagtat 139980 atatataagg agggatttca tgatatcagg aatagggttt ttattaatgg ctattagtat 140040 ggctgtatca gtacttgtag atgatatgaa gcggagtagt ttattaactg tattaggggt 140100 tcatttagta gggcttgtac tactagccat aggtatatta tgttattaat atgcattaat 140160 atgtatactt atacaatatt attaattatt ctatttttaa gttttttacc cctagtaaaa 140220 gtggtactac cttaaaaata cactgtgaat cctattaatg ggttgacttt taattaaaaa 140280 gtataaggtt ttccctaggg taaagtttta atgtacctaa atatttaagt agaagcgggt 140340 aaatctagct tactaataat gtataaaata gtgtatatcc gcttcaatta caattaattg 140400 ttgacaagta tgaagcggta tgctatactt agtatataat caattaggag gagttaatag 140460 tgaaattaca tttagataat aatattgtag aaggtacacc tgaggagtta gtaaagtatc 140520 aggagctatt aaaagagaaa ggtctaacaa aagattctga taagtctttg tctcactttg 140580 agcataagca tcaacgagtt gaacgagaag ctcgagatac ctttcaaggc ttacttggtt 140640 cactgaagct agataagtca tctataggtg caacagaaag ctctacagag gaagcggaga 140700 ccgcttctac agatattcaa gtaggagata gagtaagagt attaaatagt aaacatggtg 140760 ctgaaggaga ggctactgta actgctgtat tagaagatgg ttacgtagag ttagcaggta 140820 caaataaaaa tggaatgtat ttaactgact gggctaacca tgtatcaaac ttagagaaga 140880 tagaagatgc tcctatgggc tatacttttt ggtatataga cgacagaggt gtacttaacc 140940 accttaatgt actaaaagca acattagaag gtcattttga agattcaaca ggaactatat 141000 atacttatca ggctgtacat ggtttggtaa aacctcttga tagagaagat gttcgtgaaa 141060 agtttgaaaa agctgaggat tatgaatgcc tattaaggta ctatcctaca gtagatgtgt 141120 ttgcctggaa ataatagttg aagcggtact tatccgcttc tcctacttag agtatataag 141180 caattgtata ttgtaagtag gagtgattaa cctacagacc ttttagactg aggtcatgtc 141240 attttggttt tgttccaata agccgaccct ttacctgcca gtagagggtt tttattttaa 141300 gtgttgacat actctaagta gtatggtatg attagtatat aaattaatag gagatgaata 141360 gttatgaaat tatttataaa tggggatgta acagaaggaa cacctgagga gttatctaag 141420 tacaagaaac tagtcgaaag tgatgtagag gaaaattact tttatattgc acatggaaat 141480 aaccaaggta tagttgttaa aaaggctaat ctccataaat tatcttatgt agatacgaaa 141540 ggaaatgtcc atatattaag agacgaagat attaagacaa tatcaaatag tgatgctaaa 141600 agggttttta gtgatagtgt agaaaaagat gcgttactga tatattatct taatttcaat 141660 acctttgaga agatatattt ttaactaaaa aataataagg aggaataatt atgaataaag 141720 tattagaatt tattttttgg tatatatggt atcttataat gggatttata ggagtatggt 141780 taggtagttt aattatagga acggatatta accctcttac tagttggata ccttacgtaa 141840 ttgctttagt aatgtctgta tacgaagtta caattagtaa gtaggaggaa tagatatgag 141900 agacttatta aacttacaaa ttatttttta tatcgtaata gggttgttac tggttggctt 141960 actgtatata cctattctat tagccctcta gagctcattt aagagcataa atacaataga 142020 ggataaattg tactagaaat ataatagaag ctctctatgg acggctgaga ggtattagaa 142080 ttgaaaggag agatataatg aaagcaacta tatactgtgc taataggtac agtaaagata 142140 cattaaagag tattttaaag aaactagaag cggagaatag aaacttaaca tatagtacag 142200 acatatcaga tacaggagaa gtggatgtta ttatacaaca cactagtcta tctttttcag 142260 agttaatgga ttcttgtgat agagtaagta aagggtctga ccgcttccaa gtatttgtag 142320 gtaatcactc agggtattat ataaacggtg atttatgtat taacgaagta ggtaagttta 142380 ttgtacctag gaaaactaat atgatgatgt agagggggag atataatgat tcatatattt 142440 gtaaatgaga actatagtaa agaaacgtta ggggatttac ttaattatat taatactact 142500 gtagacaggg aattaactta tggtattaat acagactatg ataaggatat agtagttgaa 142560 acagatgacc taatagatga ggaagatgca cttgatttat cgggtatgag tcatttcaaa 142620 gatgacttat gtattattat aggagagaaa tactgtaggg gatttcttaa tggtcaccct 142680 gctcttatac gtaactatat aagggagaga ttataatgat agagattaga ttagttaagg 142740 actatgataa aagtcaatta aagtttatat tagataaaat taaagaagta gcacctagag 142800 aattaactta tgctatagaa gcggagatga atacggtaga tgttaatatt gaagatgtac 142860 tccctcataa atcacctcat gagtatgaaa aatattcaag gttacttgaa gaagatttat 142920 ggatagttat attccaagga agttatacta cttattacca a 142961

Claims (10)

스타필로코커스 크로모게네스(Staphylococcus chromogenes), 황색포도상구균(Staphylococcus aureus), 표피포도상구균(Staphylococcus epidermidis) 및 스타필로코커스 자일로서스(Staphylococcus xylosus)으로 이루어진 군에서 선택된 1종 이상의 스타필로코커스(Staphylococcus)균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-SC01(수탁번호 : KFCC11863P).
Staphylococcus chromogenes ( Staphylococcus chromogenes ), Staphylococcus aureus ), Staphylococcus epidermidis ) and Staphylococcus xylosus ) At least one selected from the group consisting of Staphylococcus xylosus ) Bacteriophage OPT-SC01 consisting of the nucleotide sequence represented by SEQ ID NO: 1 (Accession No.: KFCC11863P) having a specific killing ability for bacteria.
 삭제delete 삭제delete 제1항의 박테리오파지 OPT-SC01을 포함하는, 항생용 조성물.
A composition for antibiotics comprising the bacteriophage OPT-SC01 of claim 1.
 제1항의 박테리오파지 OPT-SC01을 포함하는, 사료 첨가용 조성물.
A composition for addition to feed, comprising the bacteriophage OPT-SC01 of claim 1.
 제5항의 사료 첨가용 조성물을 포함하는, 사료.
A feed comprising the composition for adding the feed of claim 5.
 제1항의 박테리오파지 OPT-SC01을 포함하는, 소독제.
A disinfectant comprising the bacteriophage OPT-SC01 of claim 1.
 제1항의 박테리오파지 OPT-SC01을 포함하는, 세척제.
A cleaning agent comprising the bacteriophage OPT-SC01 of claim 1.
 삭제delete 삭제delete
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WO2010033546A1 (en) 2008-09-16 2010-03-25 Intralytix, Inc. Novel staphylococcus aureus: bacteriophage and uses thereof
US20130273635A1 (en) 2012-04-12 2013-10-17 Intron Biotechnology, Inc. Bacteriophage killing pseudomonas aeruginosa and staphylococcus aureus

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