KR20180041742A - 방사선 손상에 대한 보호를 위한 세코이솔라리시레시놀 디글루코사이드(SDGs) 및 관련 화합물의 용도 - Google Patents

방사선 손상에 대한 보호를 위한 세코이솔라리시레시놀 디글루코사이드(SDGs) 및 관련 화합물의 용도 Download PDF

Info

Publication number
KR20180041742A
KR20180041742A KR1020187008184A KR20187008184A KR20180041742A KR 20180041742 A KR20180041742 A KR 20180041742A KR 1020187008184 A KR1020187008184 A KR 1020187008184A KR 20187008184 A KR20187008184 A KR 20187008184A KR 20180041742 A KR20180041742 A KR 20180041742A
Authority
KR
South Korea
Prior art keywords
subject
sdg
radiation
effective amount
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020187008184A
Other languages
English (en)
Korean (ko)
Inventor
멜포 크리스토피도-솔로미도
Original Assignee
더 트러스티스 오브 더 유니버시티 오브 펜실베니아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 filed Critical 더 트러스티스 오브 더 유니버시티 오브 펜실베니아
Publication of KR20180041742A publication Critical patent/KR20180041742A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020187008184A 2015-09-01 2016-08-31 방사선 손상에 대한 보호를 위한 세코이솔라리시레시놀 디글루코사이드(SDGs) 및 관련 화합물의 용도 Withdrawn KR20180041742A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212898P 2015-09-01 2015-09-01
US62/212,898 2015-09-01
PCT/US2016/049780 WO2017040718A1 (en) 2015-09-01 2016-08-31 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE

Publications (1)

Publication Number Publication Date
KR20180041742A true KR20180041742A (ko) 2018-04-24

Family

ID=58188252

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187008184A Withdrawn KR20180041742A (ko) 2015-09-01 2016-08-31 방사선 손상에 대한 보호를 위한 세코이솔라리시레시놀 디글루코사이드(SDGs) 및 관련 화합물의 용도

Country Status (10)

Country Link
US (1) US20180243327A1 (enExample)
EP (1) EP3344271A4 (enExample)
JP (1) JP2018528208A (enExample)
KR (1) KR20180041742A (enExample)
CN (1) CN108697748A (enExample)
AU (1) AU2016315952A1 (enExample)
CA (1) CA2997112A1 (enExample)
IL (1) IL257780A (enExample)
MA (1) MA45520A (enExample)
WO (1) WO2017040718A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3077034A1 (en) * 2017-09-27 2019-04-04 The Trustees Of The University Of Pennsylvania Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation-induced cardiovascular dysfunction

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065925B2 (ja) * 1996-01-30 2000-07-17 日清製油株式会社 活性酸素種消去剤及び退色防止剤
DE60213957T2 (de) * 2001-04-04 2007-03-08 Unilever N.V. Verwendung von lignan in nahrungsmittelprodukten
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
US10045951B2 (en) * 2007-05-25 2018-08-14 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex and its use thereof
US10449224B2 (en) * 2007-05-25 2019-10-22 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using and compositions thereof
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
WO2011053960A1 (en) * 2009-11-02 2011-05-05 Procure Treatment Centers, Inc. Compact isocentric gantry
TR201815423T4 (tr) * 2013-06-10 2018-11-21 Scripps Research Inst (s,s)-sekoi̇zolari̇si̇resi̇nol di̇glukozi̇d ve (r,r)-sekoi̇zolari̇si̇resi̇nol di̇glukozi̇d'i̇n hazirlanmasi.

Also Published As

Publication number Publication date
MA45520A (fr) 2019-05-08
IL257780A (en) 2018-04-30
EP3344271A1 (en) 2018-07-11
US20180243327A1 (en) 2018-08-30
WO2017040718A1 (en) 2017-03-09
JP2018528208A (ja) 2018-09-27
CA2997112A1 (en) 2017-03-09
AU2016315952A1 (en) 2018-04-05
EP3344271A4 (en) 2019-05-08
CN108697748A (zh) 2018-10-23

Similar Documents

Publication Publication Date Title
Maurya et al. Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions
US20160310481A1 (en) Laquinimod for treatment of cannabinoid receptor type 1(cb1) mediated disorders
US10220018B2 (en) Method of mitigating long and short term detrimental effects of exposure to low dose ionizing radiation by administration of genistein
Songarj et al. The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice
Morel et al. DMAPT is an effective radioprotector from long-term radiation-induced damage to normal mouse tissues in vivo
KR20180041742A (ko) 방사선 손상에 대한 보호를 위한 세코이솔라리시레시놀 디글루코사이드(SDGs) 및 관련 화합물의 용도
RU2485956C2 (ru) Новая композиция для лечения побочных эффектов противораковой терапии
HK1262581A1 (en) USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE
US20130039882A1 (en) Method to mitigate injury from radiation exposure
WO2017173308A1 (en) Radiation mitigator and method of use thereof
Rahmi et al. Curcumin effect on bleomycin-induced pulmonary fibrosis in Mus musculus.
DE68908146T2 (de) Schutzstoff gegen strahleneffekte.
DE1617601B2 (de) Arzneimittel zur behandlung der prostatahypertrophie
RU2846053C1 (ru) Средство, снижающее уровень генотоксического повреждения в семенниках экспериментальных животных
US20200268779A1 (en) USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
CN113144192A (zh) Mapk/erk通路抑制剂在拮抗皮肤老化与辐射性皮肤早衰中的应用
CN114081880B (zh) 木香内酯及其衍生物在制备预防和/或治疗肠损伤的药物中的用途
Shin et al. A comparative study of radioprotection with Callophyllis japonica extract and amifostine against lethal whole body gamma irradiation in mice
Mancini et al. Effect of recombinant manganese superoxide dismutase (rMnSOD) on the hematologic status in mice irradiated by protons
RU2307398C2 (ru) Способ физико-биологической профилактики острой лучевой болезни
Sapmaz et al. The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats
RU2568905C1 (ru) Способ биологической профилактики лучевой болезни
CN119326778A (zh) Ciliatoside A在制备治疗神经退行性疾病的药物中的应用
JP2018528208A5 (enExample)
KR101750847B1 (ko) 피부 내에 봉독의 분해 촉진을 위한 봉독 조성물

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20180322

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination