JP2018528208A5 - - Google Patents
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- JP2018528208A5 JP2018528208A5 JP2018511210A JP2018511210A JP2018528208A5 JP 2018528208 A5 JP2018528208 A5 JP 2018528208A5 JP 2018511210 A JP2018511210 A JP 2018511210A JP 2018511210 A JP2018511210 A JP 2018511210A JP 2018528208 A5 JP2018528208 A5 JP 2018528208A5
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- Japan
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- 238000000034 method Methods 0.000 claims description 72
- SBVBJPHMDABKJV-PGCJWIIOSA-N secoisolariciresinol diglucoside Chemical compound C1=C(O)C(OC)=CC(C[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)CC=2C=C(OC)C(O)=CC=2)=C1 SBVBJPHMDABKJV-PGCJWIIOSA-N 0.000 claims description 51
- SBVBJPHMDABKJV-UHFFFAOYSA-N secoisolariciresinol diglycoside Natural products C1=C(O)C(OC)=CC(CC(COC2C(C(O)C(O)C(CO)O2)O)C(COC2C(C(O)C(O)C(CO)O2)O)CC=2C=C(OC)C(O)=CC=2)=C1 SBVBJPHMDABKJV-UHFFFAOYSA-N 0.000 claims description 48
- 230000032683 aging Effects 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 21
- 230000005855 radiation Effects 0.000 claims description 21
- 210000001519 tissue Anatomy 0.000 claims description 8
- 230000006378 damage Effects 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000009758 senescence Effects 0.000 claims description 6
- 208000004852 Lung Injury Diseases 0.000 claims description 5
- 206010069363 Traumatic lung injury Diseases 0.000 claims description 5
- 238000002405 diagnostic procedure Methods 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 231100000515 lung injury Toxicity 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 229910052704 radon Inorganic materials 0.000 claims description 2
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 claims description 2
- PUETUDUXMCLALY-HOTGVXAUSA-N (-)-secoisolariciresinol Chemical compound C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 PUETUDUXMCLALY-HOTGVXAUSA-N 0.000 description 12
- DWONJCNDULPHLV-HOTGVXAUSA-N Enterodiol Chemical compound C([C@@H](CO)[C@H](CO)CC=1C=C(O)C=CC=1)C1=CC=CC(O)=C1 DWONJCNDULPHLV-HOTGVXAUSA-N 0.000 description 12
- AOJXPBNHAJMETF-UHFFFAOYSA-N Enterodiol Natural products OCC(Cc1ccc(O)cc1)C(CO)Cc2ccc(O)cc2 AOJXPBNHAJMETF-UHFFFAOYSA-N 0.000 description 12
- HVDGDHBAMCBBLR-UHFFFAOYSA-N Enterolactone Natural products OC1=CC=CC(CC2C(C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-UHFFFAOYSA-N 0.000 description 12
- HVDGDHBAMCBBLR-WMLDXEAASA-N enterolactone Chemical compound OC1=CC=CC(C[C@@H]2[C@H](C(=O)OC2)CC=2C=C(O)C=CC=2)=C1 HVDGDHBAMCBBLR-WMLDXEAASA-N 0.000 description 12
- OGFXBIXJCWAUCH-UHFFFAOYSA-N meso-secoisolariciresinol Natural products C1=2C=C(O)C(OC)=CC=2CC(CO)C(CO)C1C1=CC=C(O)C(OC)=C1 OGFXBIXJCWAUCH-UHFFFAOYSA-N 0.000 description 12
- 235000004239 secoisolariciresinol Nutrition 0.000 description 12
- 230000000975 bioactive effect Effects 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 7
- 229940107657 flaxseed extract Drugs 0.000 description 6
- 235000020704 flaxseed extract Nutrition 0.000 description 6
- 239000002207 metabolite Substances 0.000 description 6
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 230000000770 proinflammatory effect Effects 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000007857 degradation product Substances 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 2
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 2
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 2
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 2
- 101000973778 Homo sapiens NAD(P)H dehydrogenase [quinone] 1 Proteins 0.000 description 2
- 102100039065 Interleukin-1 beta Human genes 0.000 description 2
- 102000004889 Interleukin-6 Human genes 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 2
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940056692 resinol Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562212898P | 2015-09-01 | 2015-09-01 | |
| US62/212,898 | 2015-09-01 | ||
| PCT/US2016/049780 WO2017040718A1 (en) | 2015-09-01 | 2016-08-31 | USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018528208A JP2018528208A (ja) | 2018-09-27 |
| JP2018528208A5 true JP2018528208A5 (enExample) | 2019-10-10 |
Family
ID=58188252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511210A Pending JP2018528208A (ja) | 2015-09-01 | 2016-08-31 | 放射線損傷からの保護のためのセコイソラリシレシノールジグルコシド（ｓｄｇ）および関連化合物の使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20180243327A1 (enExample) |
| EP (1) | EP3344271A4 (enExample) |
| JP (1) | JP2018528208A (enExample) |
| KR (1) | KR20180041742A (enExample) |
| CN (1) | CN108697748A (enExample) |
| AU (1) | AU2016315952A1 (enExample) |
| CA (1) | CA2997112A1 (enExample) |
| IL (1) | IL257780A (enExample) |
| MA (1) | MA45520A (enExample) |
| WO (1) | WO2017040718A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3687545A4 (en) * | 2017-09-27 | 2021-06-09 | The Trustees Of The University Of Pennsylvania | USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3065925B2 (ja) * | 1996-01-30 | 2000-07-17 | 日清製油株式会社 | 活性酸素種消去剤及び退色防止剤 |
| ES2271261T3 (es) * | 2001-04-04 | 2007-04-16 | Unilever N.V. | Uso de ligandos en alimentos. |
| US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| US10045951B2 (en) * | 2007-05-25 | 2018-08-14 | The Trustees Of The University Of Pennsylvania | Flaxseed lignan complex and its use thereof |
| US10449224B2 (en) * | 2007-05-25 | 2019-10-22 | The Trustees Of The University Of Pennsylvania | Flaxseed lignan complex, methods of using and compositions thereof |
| WO2010017332A2 (en) * | 2008-08-07 | 2010-02-11 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services | Radioprotectants targeting thrombospondin-1 and cd47 |
| CN102687230A (zh) * | 2009-11-02 | 2012-09-19 | 普罗丘尔治疗中心有限公司 | 紧凑型等中心机架 |
| SI3007557T1 (sl) * | 2013-06-10 | 2018-12-31 | The Trusees Of The University Of Pennsylvania | Priprava (S,S)-sekoizolariciresinol diglukozida in (R,R)-sekoizolariciresinol diglukozida |
-
2016
- 2016-08-31 EP EP16842946.2A patent/EP3344271A4/en not_active Withdrawn
- 2016-08-31 US US15/757,273 patent/US20180243327A1/en not_active Abandoned
- 2016-08-31 KR KR1020187008184A patent/KR20180041742A/ko not_active Withdrawn
- 2016-08-31 MA MA045520A patent/MA45520A/fr unknown
- 2016-08-31 JP JP2018511210A patent/JP2018528208A/ja active Pending
- 2016-08-31 WO PCT/US2016/049780 patent/WO2017040718A1/en not_active Ceased
- 2016-08-31 CN CN201680055155.2A patent/CN108697748A/zh active Pending
- 2016-08-31 CA CA2997112A patent/CA2997112A1/en not_active Abandoned
- 2016-08-31 AU AU2016315952A patent/AU2016315952A1/en not_active Abandoned
-
2018
- 2018-02-27 IL IL257780A patent/IL257780A/en unknown
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