CN108697748A - 开环异落叶松树脂酚二葡萄糖苷(sdg)及相关化合物用于防止辐射损伤的用途 - Google Patents

开环异落叶松树脂酚二葡萄糖苷(sdg)及相关化合物用于防止辐射损伤的用途 Download PDF

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Publication number
CN108697748A
CN108697748A CN201680055155.2A CN201680055155A CN108697748A CN 108697748 A CN108697748 A CN 108697748A CN 201680055155 A CN201680055155 A CN 201680055155A CN 108697748 A CN108697748 A CN 108697748A
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subject
sdg
radiation
administering
aging
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CN201680055155.2A
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English (en)
Chinese (zh)
Inventor
M·克里斯托菲多-索罗米多
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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Publication of CN108697748A publication Critical patent/CN108697748A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201680055155.2A 2015-09-01 2016-08-31 开环异落叶松树脂酚二葡萄糖苷(sdg)及相关化合物用于防止辐射损伤的用途 Pending CN108697748A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212898P 2015-09-01 2015-09-01
US62/212,898 2015-09-01
PCT/US2016/049780 WO2017040718A1 (en) 2015-09-01 2016-08-31 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE

Publications (1)

Publication Number Publication Date
CN108697748A true CN108697748A (zh) 2018-10-23

Family

ID=58188252

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680055155.2A Pending CN108697748A (zh) 2015-09-01 2016-08-31 开环异落叶松树脂酚二葡萄糖苷(sdg)及相关化合物用于防止辐射损伤的用途

Country Status (10)

Country Link
US (1) US20180243327A1 (enExample)
EP (1) EP3344271A4 (enExample)
JP (1) JP2018528208A (enExample)
KR (1) KR20180041742A (enExample)
CN (1) CN108697748A (enExample)
AU (1) AU2016315952A1 (enExample)
CA (1) CA2997112A1 (enExample)
IL (1) IL257780A (enExample)
MA (1) MA45520A (enExample)
WO (1) WO2017040718A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019067729A1 (en) * 2017-09-27 2019-04-04 The Trustees Of The University Of Pennsylvania USE OF SECO-SOLARICINESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS IN THE PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTIONS

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080702A1 (en) * 2001-04-04 2002-10-17 Unilever N.V. Use of lignans in foods
WO2006073457A2 (en) * 2004-04-30 2006-07-13 Rutgers, The State University Of New Jersey Bioactive compounds and methods of uses thereof
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof
US20110135641A1 (en) * 2008-08-07 2011-06-09 The Goverment of the United States of America,as represented by theSecretary ofthe dept.of HumanSer Radioprotectants targeting thrombospondin-1 and cd47
US20110300247A1 (en) * 2007-05-25 2011-12-08 Melpo Christofidou-Solomidou Flaxseed lignan complex and its use thereof
US20140155961A1 (en) * 2005-03-24 2014-06-05 Tracie Martyn International, Inc. Methods of treating skin
WO2014200964A1 (en) * 2013-06-10 2014-12-18 The Trustees Of The University Of Pennsylvania Preparation of (s,s)-secoisolariciresinol diglucoside and (r,r)-secoisolariciresinol diglucoside

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065925B2 (ja) * 1996-01-30 2000-07-17 日清製油株式会社 活性酸素種消去剤及び退色防止剤
US8575563B2 (en) * 2009-11-02 2013-11-05 Procure Treatment Centers, Inc. Compact isocentric gantry

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080702A1 (en) * 2001-04-04 2002-10-17 Unilever N.V. Use of lignans in foods
WO2006073457A2 (en) * 2004-04-30 2006-07-13 Rutgers, The State University Of New Jersey Bioactive compounds and methods of uses thereof
US20140155961A1 (en) * 2005-03-24 2014-06-05 Tracie Martyn International, Inc. Methods of treating skin
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof
US20110300247A1 (en) * 2007-05-25 2011-12-08 Melpo Christofidou-Solomidou Flaxseed lignan complex and its use thereof
US20110135641A1 (en) * 2008-08-07 2011-06-09 The Goverment of the United States of America,as represented by theSecretary ofthe dept.of HumanSer Radioprotectants targeting thrombospondin-1 and cd47
WO2014200964A1 (en) * 2013-06-10 2014-12-18 The Trustees Of The University Of Pennsylvania Preparation of (s,s)-secoisolariciresinol diglucoside and (r,r)-secoisolariciresinol diglucoside

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OM P. MISHRA, 等: ""Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)"", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
RALPH PIETROFESA，等: ""Radiation mitigating properties of the lignan component in flaxseed"", 《BMC CANCER》 *
江启安，等: ""非小细胞肺癌质子射线放射治疗靶区及正常组织剂量分布的研究"", 《中华放射医学与防护杂志》 *

Also Published As

Publication number Publication date
KR20180041742A (ko) 2018-04-24
MA45520A (fr) 2019-05-08
WO2017040718A1 (en) 2017-03-09
JP2018528208A (ja) 2018-09-27
IL257780A (en) 2018-04-30
EP3344271A1 (en) 2018-07-11
US20180243327A1 (en) 2018-08-30
CA2997112A1 (en) 2017-03-09
AU2016315952A1 (en) 2018-04-05
EP3344271A4 (en) 2019-05-08

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