KR20180033781A - Method of producing a food for preventing and improving diabetes - Google Patents

Abstract

The present invention relates to a preparation method of a food for preventing and alleviating diabetes, and more specifically, to a preparation method of a food for preventing and alleviating diabetes, configured to prevent and alleviate diabetes, which commonly afflict modern people, without causing adverse effects to a human body. The preparation method comprises: a) mixing 54.5-71.5 wt% of balsam apples, 8.0-11.5 wt% of Chinese dioscorea, 4.5-7.4 wt% of Morus alba L. leaves, 1.5-2.5 wt% of onions, 3.5-5.8 wt% of milk thistle, 1.5-2.5 wt% of brown rice, 1.5-2.5 wt% of black beans, 1.5-2.5 wt% of pine needles, 1.5-2.5 wt% of Angelica gigas, 1.5-2.5 wt% of black sesame, and 1.5-2.5 wt% of ginger, to produce a mixture; b) adding water to 50-54 wt% of Morus alba L. leaves and 46-50 wt% of Acanthopanax and conducting a hot-water extraction at a temperature of 70-80°C for 2-3 hours to produce an extract; c) filtering the extract in the step b) to produce a filtrate; d) concentrating the filtrate produced in the step c) to a concentration of 23 brix or more to produce a concentrate; and e) mixing the mixture produced in the step a) with the concentrate produced in the step d) in a ratio of 1:0.4-0.6.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

More particularly, the present invention relates to a method for preventing or ameliorating diabetes mellitus, which is frequently occurred in modern people, without adverse effects on the human body, The present invention also relates to a method for producing a food for preventing and improving diabetes.

Diabetes is the most common and serious lifestyle disease, with over one million patients worldwide. Furthermore, although the blood glucose level (blood sugar level) does not reach the diabetic level, the number of people called for maintenance, the so-called prospective patient, is higher than the number of diabetics because the blood glucose level is higher than that of normal people.

On the other hand, diabetes is known to have Type I diabetes (insulin-dependent diabetes) due to insulin secretion deficiency (insulin-dependent diabetes) and type II diabetes (insulin-independent diabetes) due to a decrease in insulin sensitivity have. Most of the diabetic patients are type Ⅱ diabetes, and this type of diabetes is often caused by inappropriate lifestyle such as overeating.

As such, the problem of diabetes is that it is relatively difficult to control blood sugar for a long time because there are few subjective symptoms due to hypertension, thereby causing various complications (retinopathy, nephropathy, arteriosclerosis, etc.). For example, in Japan, diabetic retinopathy is the first leading cause of visual disturbance after becoming an adult, and diabetic nephropathy is the second leading cause of artificial dialysis due to chronic renal failure.

As such, diabetic causes serious complications, so the main purpose of diabetes treatment is to manage thorough blood glucose control. Although insulin injection has an absolute effect on blood glucose control of patients with type I diabetes because insulin secretion is the cause, the insulin sensitivity of patients with type II diabetes is lowered, so the effectiveness of insulin injections ) In many cases.

Treatment of these type II diabetes patients includes dietary restrictions to limit excessive dietary calorie intake and exercise to promote calorie consumption in the body. Dietary restrictions, if continued for a long period of time, Can be adversely affected.

Therefore, the use of diabetes medicines (sulfonylureas, acetaminides, etc.) is attempted in patients who do not have noticeable progress with dietary restriction and exercise therapy, and these drugs have great problems. For example, sulfonylureas (SU agents) have been used for a long time since the 1970s, but the blood sugar level is too low to cause hypoglycemia. In addition, because it increases the hunger feeling, it is easy to deviate from the dietary restriction, and the control of the blood sugar is made to fail, and also the obesity is promoted in many cases. Because of these problems, strict control by physicians is essential when using sulfonylureas.

On the other hand, although an acetylating agent (BG agent) has also been used since the 1970s, there have been many reports of the occurrence of lactic acid acidosis as a side effect of this agent shortly after use. Recently, its use and effectiveness have been reviewed, but the use of acetaminophen in the strict management of the physician is also essential.

In this situation, the development of a new oral (经 口) diabetes drug has been attempted, and α-glucosidase inhibitors and insulin action enhancers have been developed, but the effect has not yet been verified. Currently, insulin action enhancer troglitazone (troglitazone) has been stopped due to the side effects of liver damage (liver damage).

As described above, there is almost no safe oral medicine that can be safely used for patients with diabetes. It is not an exaggeration to say that the method which can expect the actual treatment effect is the dietary restriction. However, as mentioned above, If you go out, it can adversely affect your health.

To overcome the shortcomings of this dietary restriction, many low-calorie foods for diabetes have been developed, but the contribution to the treatment of diabetes is only marginal. In addition, there is currently no treatment for the complications that are characteristic of diabetes. Therefore, it is currently being used to prevent complications by managing blood glucose levels.

Therefore, for diabetes, it is required to develop a useful drug which is highly safe for human body, or an effective functional food which can be safely consumed even during dietary restriction.

Korean Patent Laid-Open No. 10-2015-0038218 (Aug. Korean Patent Publication No. 10-2010-0123300 (Nov. 24, 2010) Korean Patent Laid-Open No. 10-2006-0105431 (November 11, 2006)

Accordingly, the present inventors have intensively studied foods that can improve or prevent diabetes mellitus with high stability to the human body. As a result, the inventors of the present invention found that the food prepared by the method of the present invention activates the action mechanism of anti-diabetic, The present inventors have completed the present invention.

The composition of the present invention comprises a) 54.5 to 71.5% by weight of flax, 8.0 to 11.5% by weight of acid, 4.5 to 7.4% by weight of onion, 1.5 to 2.5% by weight of onion, 3.5 to 5.8% Preparing 1.5 to 2.5% by weight of pine needle, 1.5 to 2.5% by weight of pine needle, 1.5 to 2.5% by weight of Angelica keiskei, 1.5 to 2.5% by weight of blackberry and 1.5 to 2.5% by weight of health; b) adding water to 50 to 54% by weight of the upper leaves and 46 to 50% by weight of the oak, extracting the extract after 2 to 3 hours of hot water extraction at a temperature of 70 to 80 ° C; c) filtering the extract of step b) to obtain a filtrate; d) concentrating the filtrate of step c) until the concentration reaches 23 brix or more to obtain a concentrate; e) mixing the mixture of step a) and the concentrate of step d) in a ratio of 1: 0.4-0.6.

The filtrate of step c) is obtained by centrifuging the extract of step b) to obtain a supernatant, and then filtering the supernatant.

In addition, the brown rice in the step (a) is characterized in that any one or both of the brown rice embryo or the colony layer is mixed.

In addition, the mixture obtained through step e) is characterized in that it is formulated into a powder, a pill, a tablet, a capsule, a liquid and a suspension.

The diabetes preventive and remedy food prepared by the method of the present invention having the above-described structure can lower the insulin resistance in the plasma by lowering the insulin resistance, and can lower the blood sugar while reducing insulin resistance or insulin sensitivity (Susceptibility), thereby preventing and improving diabetes, and the ingredients showing efficacy are made of natural substances, so that they do not have side effects on the human body, and they are formed into various formulations to expand the versatility So that it is highly likely to be used industrially.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process diagram showing a method of manufacturing a food for preventing and improving diabetes according to a preferred embodiment of the present invention; FIG.

As shown in Fig. 1, the method of the present invention for producing diabetes preventive /

a) Leeks 54.5 - 71.5% by weight, Acacia 8.0 - 11.5% by weight, Upper leaf 4.5 - 7.4% by weight, Onion 1.5 - 2.5% by weight, Milk Seeds 3.5 - 5.8% by weight, Brown rice 1.5 - 2.5% Preparing 1.5 to 2.5 wt% of pine needle, 1.5 to 2.5 wt% of Angelica keiskei, 1.5 to 2.5 wt% of blackberry, and 1.5 to 2.5 wt% of health to prepare a mixture;

b) adding water to 50 to 54% by weight of the upper leaves and 46 to 50% by weight of the oak, extracting the extract after 2 to 3 hours of hot water extraction at a temperature of 70 to 80 ° C;

c) filtering the extract of step b) to obtain a filtrate;

d) concentrating the filtrate of step c) until the concentration reaches 23 brix or more to obtain a concentrate;

e) mixing the mixture of step a) and the concentrate of step d) in a ratio of 1: 0.4-0.6.

Hereinafter, each raw material used in the food produced by the above-described method will be described.

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1) Yeoju

Margose contains plant insulin and carraenine, which helps insulin secretion and breakdown of blood sugar, and is excellent in blood sugar (hypoglycemic) action. In addition, vitamin C is very abundant, fatigue and eye health, as well as skin moisturizing, skin aging prevention, skin trouble improvement, skin soothing effect. In addition, it has the efficacy of relieving the symptoms of swelling and pain, epidemics and swelling and tingling of the skin.

2)

Sanmek (山药) when the appetite is weak and refreshing, it is taken in conjunction with Baekjung, Yongbap, Ginseng, etc., and if you have semen leaking or sweating when you sleep, it will be taken with Sukjihuang, In addition, it enhances non-functioning (splenic function) to control seizures, asthma, and sputum by controlling lethargy, helplessness, food reduction, diarrhea and so on. Symptoms, physical weakness, anemia, and limb paralysis. The main effects were stimulation of intestinal activity, hypoglycemia, and anti-aging effects.

3)

Mulberry leaves are dried with leaves of mulberry trees and mountain mulberry trees, also called frost 桑葉. Taste is appetite, temperate and cool, and acts on menopause (肺 经) and liver (肝 经). It also eliminates wind chill, eliminates hemorrhagic fever, stops bleeding, and heals eye diseases. The main effects were hypoglycemic action, hypotensive action, diuretic action and antibacterial action.

4) Onions

Onions are harvested mainly in June-July when the leaves fall and have a slight green color. Some scales are picked before the leaves are edited. The onion is mainly used for edible use of scaly stem. The unique smell from the stem of the scales is due to compounds such as propyl sulfite and allyl sulfide. It physiologically promotes the secretion of digestive juices and has effects such as excitement, sweating, and diuretic.

5) Milk seeds

Milk seeds (milk thistle) is a component of the silymarin (silymarin) is effective for the action of silymarin protects the cell membrane from the free radicals to keep the cells strong, especially strong affinity for hepatocytes . The antioxidant role of silymarin in the liver is about 10 times that of vitamin E, and by increasing the concentration of superoxide dismutase and glutathione, which are strong antioxidants, It also acts as an antioxidant. In addition, it acts to regulate blood sugar and shows good efficacy against diabetes.

6) Brown rice

Brown rice is an embryo whose structure occupies a small part of the base of the rice grain called pebbles such as pericarp, seed coat and lacustrine layer, Respectively. The weight ratio of each part to the brown rice is 5 - 6% for the bottom layer, 2 - 3% for the embryo and 92% for the endosperm. The main effect of brown rice is that brown rice is rich in fiber, which is good for constipation, it releases heavy metals in the body, and detoxification substance called phytic acid in brown rice embryo decodes pesticides and detergents. In addition, it makes your skin healthy, and brown rice cleanses your body and body.

7) Seomok-tae

Seomok-tae is a type of black bean, whose skin is black and its size is much smaller than that of black beans. In particular, it is excellent in medicine and has been used for medicines since ancient times rather than edible. Seomyeongtae is recognized as a good food for prevention and treatment of various diseases such as hypertension, arteriosclerosis and heart disease. Diabetes patients, especially in the morning and evening fasting, diarrhea without symptoms of diarrhea is very helpful for the treatment of diabetes. In addition, it has excellent detoxification ability to recover the destroyed human tissue at a rapid rate and to release various toxicities.

8) Pine needles

According to Dongbokbo, pine needles do not age when grown for a long time, become refreshing, their hair become black, and they do not know cold and hunger. Pine needles contain a lot of vitamin A, which cleanse blood and prevent hypertension. It also has the effect of preventing geriatric diseases such as liver diseases, gastrointestinal diseases, neurological diseases, circulatory diseases and skin protection and stroke, arteriosclerosis, hypertension and diabetes.

9) Angelicae

It is said that the gangwi (當 帰) is named 'Duckwoo' with the intention of wanting to return. This is because of the tradition of long ago in China, when the wife was worried about her husband going to the battlefield and put Angelica in her bracelet, she believed that when she was full of energy on the battlefield, she could recover her energy again after eating Angelica. The main efficacy is predominantly the blood-producing (blood-producing) action of producing blood when blood is scarce. Chinese Angelica, why Angelica, made from the root of Angelica gigas, is excellent in blood circulation. However, Angelica root, made from the root of Angelica gigas, has better antithrombotic effect and blood pressure lowering effect, which makes the blood circulate more smoothly than the blood.

10) The black soldier

Black saucer has been regarded as a longevity food and has been regarded as a medicine since it has been a black sesame among black beans in China since ancient times. In Korea, it was also used as food for health and longevity. Selenium (sesamol), which is an excellent antioxidant tocopherol (tcoferol), is an essential amino acid for vigor, and has an excellent effect on the activity of DNA constituting the cell and the preventive and therapeutic effect of dementia. Sesaminol and other ingredients. It is also known that it has anticancer efficacy. According to the animal test report, it is said that the skin cancer suppressing ability is about 60%, the gastric cancer suppressing ability is about 85%, and the lung cancer suppressing ability is about 75%.

11) Health

Health (also known as "ginger") is a Hindu-Dan area in the East India, which is believed to be the country of origin and was cultivated about 2,500 years ago in China. Now Sichuan province is known as the origin of health. In Korea, the contents of health cultivation were recorded for the first time in Goryeo (9th year of King Hyeongjong, 1018) and it is recorded that the health was written by the royal family. Main effects include stimulation of gastric juice secretion, activation of intestinal peristalsis, promotion of digestion, vomiting, sedation, stimulation of the heart, blood pressure and blood circulation. It also has anti-inflammatory, analgesic and acaricidal action.

12) Ogaki

Ogaki (五加皮) is divided into five leaves, it is good to have five leaves on one branch, called Oga, and now it is described as Oga (五 加). Main effects include immune enhancement, antioxidant, anti-fatigue, anti-hypertension, anti-irritation, endocrine control, blood pressure control, anti-radioactivity and detoxification.

Hereinafter, a method for preparing a food for preventing or improving diabetes using raw materials having the above-described effects will be described separately for each step.

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a) Step

Wherein the step a) comprises the steps of: 54.5 to 71.5% by weight of mallow, 8.0 to 11.5% by weight of acid, 4.5 to 7.4% by weight of onion, 3.5 to 5.8% by weight of onion, 3.5 to 5.8% Preparing 1.5 to 2.5% by weight of pine needle, 1.5 to 2.5% by weight of pine needle, 1.5 to 2.5% by weight of Angelica keiskei, 1.5 to 2.5% by weight of blackberry and 1.5 to 2.5%

The raw materials listed above can be subjected to a pretreatment step, such as washing each raw material in clean water and then pulverizing to an appropriate size. At this time, it is possible to remove the foreign substances on the surface, and in the case of the fruit including the seed, the seeds contained therein can be removed.

Here, the raw materials are preferably finely pulverized so as to exhibit an effective effect of the effective component, but the size of the powder particles is not particularly limited.

On the other hand, it is recommended that the Yeoju be matured about 10 - 20cm long harvested in July. This is due to the fact that the immature rumen contains a large amount of active ingredients such as plant insulin (p-insulin), carantine, vitamin C and the like. If the yeast is contained in an amount less than 54.5% by weight based on the total weight, the activity of the plant insulin and carotene ingredient is insufficient. If the yeast content exceeds 71.5% by weight, the bitter taste may become strong.

If the amount is less than 8% by weight based on the total weight, the blood glucose lowering action is insufficient. When the amount is more than 11.5% by weight, .

If the content of the topical leaf is less than 4.5% by weight based on the total weight of the raw material, the blood pressure lowering action and the diuretic action as well as the blood glucose lowering action, If it is contained in an amount exceeding 7.4% by weight, the bitter taste and sweet taste may become very strong.

The onion is best harvested from June to July when the leaves collapse and have a slight green color, because the activity of the compounds such as sulfite propylate and allyl sulfide becomes most active. On the other hand, when the onion is contained in an amount of less than 3.5% by weight based on the total weight, penetration of the active ingredient into the human body may become difficult due to the effect of the onion, that is, the promotion of digestive juice secretion, If it is contained, the profile of sulfurous acid and the allyl sulfide component are over-mixed, and the odor peculiar to the onion may be intensified.

The milk seeds have a beneficial effect on the components of silymarin. The components of the silymarin not only keep the cells strong but also have a strong affinity for hepatocytes. In addition, it has excellent blood glucose control function and shows good efficacy on diabetes. On the other hand, if the milkcass is contained in an amount less than 3.5% by weight based on the total weight of the composition, the component of the silymarin is insufficient and it is difficult to exhibit the above effect. If the milkcumin is contained in an amount exceeding 5.8% by weight, There is a high possibility of having an adverse effect on each other.

The brown rice may have various names according to its structure. In the present invention, any one or both of a brown rice embryo or a colony can be used. The brown rice also releases heavy metals in the body, and phytic acid, a detoxifying substance, cleanses the body and body. In addition, the brown rice embryo and the colonic layer are rich in linolenic acid, which is good for arteriosclerosis and anti-aging. On the other hand, when the brown rice is contained in an amount less than 1.5% by weight based on the total weight, it is difficult to exhibit the above-mentioned effect. When the brown rice is contained in an amount of more than 2.5% by weight, the above-mentioned effect can be sufficiently exhibited. Can not do it.

This is a kind of black bean, which is recognized as a good food for prevention and treatment of adult diseases such as hypertension, arteriosclerosis and heart disease, and shows excellent efficacy especially for diabetic patients. On the other hand, if it is contained in an amount of less than 1.5% by weight based on the total weight, the mechanism of anti-action against the prevention or treatment of adult diseases or diabetes is lowered, and if it is contained in an amount exceeding 2.5% by weight, the cost is not economical.

The pine leaves are rich in vitamin A, which cleans blood and prevents hypertension. In particular, the effect of preventing diseases such as diabetes and hypertension is excellent. On the other hand, when the pine needle is contained in an amount of less than 1.5% by weight based on the total weight of the pine needle, the above-mentioned effect, that is, the mechanism of action to prevent geriatric diseases such as diabetes and hypertension is insufficient. Possibilities may arise.

The Angelica gigas have excellent anticancer effect and blood pressure lowering effect, which are excellent in blood circulation (blood supply) for producing blood and blood circulation (blood) for circulating blood smoothly. It is less than 1.5% by weight based on the total weight In other words, the above-mentioned efficacy, that is, the blood circulation effect, the hysteresis effect, the anticancer effect and the blood pressure lowering effect are insufficient, and when it exceeds 2.5 wt%, the human body may overheat.

The black potato is a food that has been regarded as a longevity food since ancient times. It is rich in tocopherol which is antioxidative, and has an effect of excelling the activity of DNA which is a cell constituent. On the other hand, when the black sugar is contained in an amount of less than 1.5% by weight, the antioxidative activity and the activity of DNA activity are insufficient. If the black star is contained in an amount of more than 2.5% by weight, the cost is not economical.

The health is another name of 'ginger', which excites the heart with its main effect, which increases blood pressure and promotes blood circulation. On the other hand, when the health is less than 1.5% by weight, the blood circulation is decreased. When the health is more than 2.5% by weight, the blood pressure may rise rapidly above the reference value due to excessive blood circulation.

Therefore, according to the critical significance of each raw material as described above, in step a), 54.5 wt% to 71.5 wt% of mallow, 8 wt% to 11.5 wt% of mung bean, 4.5 wt% to 7.4 wt% From 1.5% to 2.5% by weight of brown rice, from 1.5% to 2.5% by weight of pine needle, from 1.5% by weight to 2.5% by weight of Angelica seeds, from 3.5% to 5.8% By weight, from 1.5% by weight to 2.5% by weight of black tea, and from 1.5% by weight to 2.5% by weight of health.

b) Step

The step b) comprises adding water to 50 to 54% by weight of the top leaf and 46 to 50% by weight of the ophthalmic solution, subjecting the extract to hot water extraction at a temperature of 70 to 80 ° C for 2 to 3 hours,

In the above step, water is added to 50% by weight to 54% by weight of the upper leaves and 46% to 50% by weight of the raw oak by hot water extraction to extract the upper leaves and the oak, and the water is heated for 2 to 3 hours at a temperature of 70 to 80 ° C. And an extract is obtained through an extraction process. The water is preferably added 8 to 10 times as much water as the weight of the upper leaves and the oak.

At this time, when the water is added outside the above-mentioned range, there is a possibility that the effective ingredient of the upper leaves and the oak is not sufficiently obtained in the whole food manufacturing process. Therefore, it is preferable to add water of 8 to 10 times as much as the raw material.

Here, the hot water extraction process can be performed using a conventional hot water extraction method.

The hot water extraction process is performed while maintaining a constant temperature within a temperature range of 70 ° C. to 80 ° C. than usual. In order to keep the temperature constant at such a constant temperature, hot air, hot air, The temperature can be kept constant by adopting any one of the steam circulation system, the heat exchanger system, the circulation system, the ondol system, and the hot heat circulation system.

In order to maintain the constant temperature condition, it is preferable to use a heat insulating material, a heat insulating material or the like so that the internal temperature is not influenced by the outside. This is intended to reduce the external impact of quality.

In addition, when the hot water extraction process is performed, the contents may be stirred periodically so that the active ingredients of the raw material are uniformly mixed and extracted.

c) Step

In the step c), the extract solution obtained in step b) is filtered to obtain a filtrate,

In this step, a filtrate (filtrate) can be obtained by centrifugation (separation of solid particles or liquid fine particles in the liquid by centrifugal force) by filtration of the extract liquid. Through the centrifugation method, components having a small density difference of fine particles are separated Thereby maximizing the content of the active ingredient and further improving the functional efficacy. In addition, the centrifuged filtrate has a high solubility or a high degree of absorption and can facilitate the formulation.

d) Step

The step d) comprises concentrating the filtrate of step c) until the concentration reaches 23 brix or more to obtain a concentrate,

In this step, an organic solvent for concentration can be further used. The organic solvent is preferably an alcohol, but is not limited thereto. Any organic solvent conventionally used in the concentration process may be used in the present invention.

Meanwhile, the filtrate is preferably concentrated until the concentration reaches 23 brix or more.

Here, when the filtrate is concentrated to 23 brix or more, the viscosity becomes high. When the concentration is more than 23 brix, the sufficient effective ingredient is discharged and the harmony with other materials is performed well. As a result, the components of the raw materials described above can be combined to enhance the functional effect, that is, the diabetic improvement and prevention effect, which is an object to be achieved in the present invention.

e)

The step e) comprises mixing the mixture of step a) and the concentrate of step d) in a ratio of 1: 0.4-0.6,

The mixture of step a) and the concentrate of step d) are mixed at a ratio of 1: 0.4-0.6 to finally prepare a diabetic preventive and remedy food according to the present invention.

Here, the food prepared through the step (e) is in the form of a liquid, and the components commonly used in the art are selected and used as a powder, a pill, a tablet, a capsule, a solution or a suspension Can be formulated. It goes without saying that any other formulations conventionally produced in the art may be used in addition to the above-mentioned formulations.

Hereinafter, the present invention will be described in more detail with reference to examples and test examples.

[Example 1]

According to the production method of the present invention, the raw materials shown in Table 1 below were powdered and mixed. In order to obtain the extract of the upper leaves and ogapi, 1.6 g of water was added to 208 g of the upper leaves and 192 g of ogapi and subjected to a hot water extraction process at a temperature of 75 캜 for 3 hours. The extract solution obtained by the hot water extraction process was centrifuged to take only the supernatant and the supernatant was concentrated until the concentration reached 23 brix to obtain a concentrate. The concentrate was mixed with the concentrate at a ratio of 1: 0.5, Was prepared.

Raw material Content (unit: g) Yeoju 250 Light 40 The top 30 onion 16.8 Milk seeds 20 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Example 2]

The food was prepared by the same test conditions and manufacturing method as in Example 1 except that the contents of the raw materials were different as shown in Table 2 below.

Raw material Content (unit: g) Yeoju 240 Light 36 The top 20 onion 20 Milk seeds 25 Brown rice 8 Seomok-tae 8.8 pine needles 9 Angelica 9 Black soldier 9 health 9

[Example 3]

The food was prepared by the same test conditions and manufacturing method as in Example 1 except that the contents of the raw materials were different as shown in Table 3 below.

Raw material Content (unit: g) Yeoju 280 Light 44 The top 28 onion 22 Milk seeds 22.4 Brown rice 8 Seomok-tae 6.8 pine needles 7.2 Angelica 9 Black soldier 9 health 9

[Example 4]

Food was prepared by the same test conditions and manufacturing method as in Example 1 except that the contents of the raw materials were different as shown in Table 4 below.

Raw material Content (unit: g) Yeoju 228 Light 36 The top 23.6 onion 22.4 Milk seeds 20.8 Brown rice 9.2 Seomok-tae 8.4 pine needles 10 Angelica 9 Black soldier 9 health 9

[Example 5]

Glyquidone, a commonly used medicament for the treatment of diabetes, was obtained and applied to Example 5.

[Example 6]

In general, the Chinese medicinal herb, which is used for the treatment of diabetes, was obtained and applied to Example 6.

[Comparative Example 1]

Food was prepared by the same test conditions and manufacturing method as in Example 1, except that only the raw material contained in the raw materials was excluded, as shown in Table 5 below. In addition, it contained about two times or more as much as the raw material contained in Example 1 so that the overall weight became similar to that of Example 1.

Raw material Content (unit: g) Light 80 The top 60 onion 33.6 Milk seeds 40 Brown rice 17.6 Seomok-tae 18 pine needles 18 Angelica 17 Black soldier 18 health 18

[Comparative Example 2]

The food was prepared by the same test conditions and manufacturing method as in Example 1, except that only the raw materials contained in the raw materials were included, as shown in Table 6 below.

Raw material Content (unit: g) Yeoju 250 The top 30 onion 16.8 Milk seeds 20 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Comparative Example 3]

The food was prepared by the same test conditions and manufacturing method as in Example 1 except that only the milk seeds contained in the raw materials contained were excluded, as shown in Table 7 below.

Raw material Content (unit: g) Yeoju 250 Light 40 The top 30 onion 16.8 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Comparative Example 4]

The food was prepared by the same test conditions and manufacturing method as in Example 1, except that the raw material and raw materials contained in the raw materials were excluded, as shown in Table 8 below. In addition, it contained about two times or more as much as the raw material contained in Example 1 so that the overall weight became similar to that of Example 1.

Raw material Content (unit: g) The top 60 onion 33.6 Milk seeds 40 Brown rice 17.6 Seomok-tae 18 pine needles 18 Angelica 17 Black soldier 18 health 18

[Comparative Example 5]

The food was prepared by the same test conditions and manufacturing method as in Example 1, except for the raw material and the milk seeds contained in the raw materials as shown in Table 9 below. In addition, it contained about two times or more as much as the raw material contained in Example 1 so that the overall weight became similar to that of Example 1.

Raw material Content (unit: g) Light 80 The top 60 onion 33.6 Brown rice 17.6 Seomok-tae 18 pine needles 18 Angelica 17 Black soldier 18 health 18

[Comparative Example 6]

Foods were prepared by the same test conditions and manufacturing method as in Example 1, except that the raw materials and milks seeds contained in the raw materials were excluded, as shown in Table 10 below.

Raw material Content (unit: g) Yeoju 250 The top 30 onion 16.8 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Comparative Example 7]

The food was prepared by the same test conditions and manufacturing method as in Example 1, except that the raw material, the liquorice, and the milk seeds contained therein were excluded, as shown in Table 11 below. In addition, it contained about two times or more as much as the raw material contained in Example 1 so that the overall weight became similar to that of Example 1.

Raw material Content (unit: g) The top 60 onion 33.6 Brown rice 17.6 Seomok-tae 18 pine needles 18 Angelica 17 Black soldier 18 health 18

[Comparative Example 8]

The food was prepared by the same test conditions and manufacturing method as in Example 1 except that the content of Yeoju was used out of the preferable weight ratio of the present invention as shown in Table 12 below.

Raw material Content (unit: g) Yeoju 200 Light 40 The top 30 onion 16.8 Milk seeds 20 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Comparative Example 9]

The food was prepared by the same test conditions and manufacturing method as in Example 1, except that the content of the liquorice was used outside the preferred weight ratio of the present invention, as shown in Table 13 below.

Raw material Content (unit: g) Yeoju 250 Light 24 The top 30 onion 16.8 Milk seeds 20 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Comparative Example 10]

The food was prepared by the same test conditions and manufacturing method as in Example 1, except that the contents of the upper leaves were used outside the preferred weight ratios of the present invention, as shown in Table 14 below.

Raw material Content (unit: g) Yeoju 250 Light 40 The top 17 onion 16.8 Milk seeds 20 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Comparative Example 11]

The food was prepared by the same test conditions and manufacturing method as in Example 1 except that the content of milk seeds was used outside the preferred weight ratio of the present invention as shown in Table 15 below.

Raw material Content (unit: g) Yeoju 250 Light 40 The top 30 onion 16.8 Milk seeds 12 Brown rice 8.8 Seomok-tae 9 pine needles 9 Angelica 8.5 Black soldier 9 health 9

[Test Example 1] Test for hypoglycemic effect

In order to test the blood glucose-enhancing effect, a model animal of the type II diabetes (non-insulin dependent diabetes mellitus) (rat, mouse) Crude protein, calcium, phosphorus, and crude protein of 25% or more) were fed in a free-of-feed manner.

Herein, the type II diabetes mellitus is briefly mentioned. Although a definite mechanism of type II diabetes is not known, obesity causes an increase in resistance to insulin in the peripheral tissues, resulting in hyperinsulinemia. [Beta] cells of type II diabetic patients do not recognize the excretion of glucose into the urine due to decreased responsiveness to insulin secretion due to elevated blood glucose, and secrete insulin continuously.

A total of 360 KKAy mice (type II diabetic rats) showing these symptoms were divided into 18 groups (control group, test group 1 to 17) in 20 animals. In the control group, only the physiological saline solution was administered at a dose of 10 ml / kg. In the test groups 1 to 4, the food of the liquid form of the present invention prepared in Examples 1 to 4 was administered orally at a dose of 0.5 g / . In the test group 5, gliquidone was administered at a dose of 0.5 g / kg / day for 5 weeks, and test group 6 was administered at a dose of 0.5 g / kg / day for 5 weeks Respectively. In the test groups 7 to 13, the food in the liquid form prepared in Comparative Examples 1 to 7 and in the test groups 14 to 17, the liquid foods prepared in Comparative Examples 8 to 11 were mixed at a rate of 0.5 g / kg / day Weekly.

Blood was collected from the mouse's Retro-Orbital plexus before administration of the drug and 2 hours after administration of the drug, respectively, for the control and test groups, and glucose was measured using a glucose-meter Glucose unit: mg / dl).

The measurement results are shown in Table 16 below.

division Before administration After administration Control group 162 ± 23.4 172 ± 22.5 Test group 1 161 ± 23.2 115 ± 12.6 Test group 2 161 ± 23.2 116 ± 12.4 Test group 3 161 ± 23.2 118 ± 11.6 Test group 4 161 ± 22.2 119 ± 11.8 Test group 5 162 ± 22.1 112 ± 12.2 Test group 6 162 ± 22.1 114 ± 12.1 Test group 7 161 ± 23.2 130 ± 12.6 Test group 8 161 ± 23.2 135 ± 12.8 Test group 9 161 ± 23.2 148 ± 20.3 Test group 10 161 ± 23.2 153 ± 20.3 Test group 11 161 ± 23.2 150 ± 20.8 Test group 12 161 ± 23.2 124 ± 20.2 Test group 13 161 ± 23.2 145 ± 18.8 Test group 14 161 ± 23.2 141 ± 20.8 Test group 15 161 ± 23.2 159 ± 20.3 Test group 16 161 ± 23.2 140 ± 20.5 Test group 17 161 ± 23.2 132 ± 20.4

According to Table 16 above, it can be seen that the inventive foods (test groups 1 to 4) exhibit significant blood glucose lowering effects on type II diabetes when compared with the control group.

In addition, the food of the present invention is similar to glycidon (test group 5), which is a representative sulfonylurea type diabetes treatment drug already proven efficacy, and the blue deep-eared consonant (test group 6), a herbal preparation for treating diabetes, It can be confirmed that the blood glucose lowering effect is exhibited.

The food prepared according to the present invention at specific ratios according to the present invention can be used in the case of using these raw materials singly or only partially (Test Groups 7 to 13) or when they are manufactured outside this ratio (Test Groups 14 to 17 ), It can be confirmed that the blood glucose lowering effect is excellent.

[Test Example 2] Acute toxicity test

The LD ₅₀ value of acute toxicity was determined for the food of the present invention using an experimental animal.

As an experimental animal, 100 ICR mice were used and fasted for 1 day prior to the experiment. These mice were divided into 5 groups (20 to 20 mice). As a control group, only 10 ml / kg of physiological saline solution was administered to the dogs, and the food of the present invention prepared in Example 1 was administered at a dose of 10 g / kg / day. The food of Example 1 was used at a dose of 30 g / kg / day, the lagoon at a dose of 60 g / kg / day, the food of Example 1 at a dose of 100 g / kg / day .

The experimental results are shown in Table 17 below.

Administered ingredient
(Dose) After 24 hours
Number of dead animals It's gone. Saline solution
(10 ml / kg) - I am. The food of the present invention
(10 g / kg / day) - Dagun The food of the present invention
(30 g / kg / day) - lagoon The food of the present invention
(60 g / kg / day) One The The food of the present invention
(100 g / kg / day) 2

According to Table 17, the food of the present invention was dissolved or dissolved in physiological saline and administered orally to the animals of Groups I and II. Twenty-four hours after oral administration, the number of dead animals in each group was determined. As a result, there were no dead animals in Nago and Da - gun, 1 animal in lagoon and 2 animals in marine.

In order to obtain the LD ₅₀ , 50% of the experimental animals, that is, 10 mice, which are experimental animals, should be dosed at an increased dose, but the food of the present invention is not soluble in water, To dissolve the drug, the volume of the drug is too large to be administered to an experimental animal.

As a result, there was no experimental animal in which the side effects such as hypoglycemia were caused in the food of the present invention, the LD ₅₀ was estimated to be 100 g / kg or more.

Since the administration of 100 g / kg / day has the effect of administering the food of the present invention at least 7 kg per day when converted to 70 kg, which is the average weight of Korean, the food of the present invention is a safe food having substantially no toxicity .

Claims (4)

a) Leeks 54.5 - 71.5% by weight, Acacia 8.0 - 11.5% by weight, Upper leaf 4.5 - 7.4% by weight, Onion 1.5 - 2.5% by weight, Milk Seeds 3.5 - 5.8% by weight, Brown rice 1.5 - 2.5% Preparing 1.5 to 2.5 wt% of pine needle, 1.5 to 2.5 wt% of Angelica keiskei, 1.5 to 2.5 wt% of blackberry, and 1.5 to 2.5 wt% of health to prepare a mixture;
b) adding water to 50 to 54% by weight of the upper leaves and 46 to 50% by weight of the oak, extracting the extract after 2 to 3 hours of hot water extraction at a temperature of 70 to 80 ° C;
c) filtering the extract of step b) to obtain a filtrate;
d) concentrating the filtrate of step c) until the concentration reaches 23 brix or more to obtain a concentrate;
e) mixing the mixture of step a) and the concentrate of step d) in a ratio of 1: 0.4-0.6. The method according to claim 1,
Wherein the filtrate of step c) is obtained by centrifuging the extract of step b) to obtain a supernatant, and then filtering the supernatant. The method according to claim 1,
Wherein the brown rice of step (a) is a mixture of any one or both of a brown rice embryo or a colony layer. The method according to claim 1,
Wherein the mixture obtained through step e) is formulated into any one of powder, pills, tablets, capsules, liquids and suspensions.

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