KR20130041494A - The composition for treating diabetes - Google Patents

Abstract

PURPOSE: A composition for treating diabetes using Gynura procumbens (Lour.) Merr. is provided to reduce blood pressure, to prevent and treat diabetes, and to help blood circulation. CONSTITUTION: A composition for treating diabetes contains 60-90 wt% of dried and pulverized Gynura procumbens (Lour.) Merr. leaves, 5-30 wt% of dried and pulverized pine needles, 1-5 wt% of honey, 1-5 wt% of Cordyceps militaris, and 0.5-3 wt% of a Lespedeza cuneata extract. The Lespedeza cuneata extract is prepared by mixing Lespedeza cuneata and water in a weight ratio of 1:3.5, heating at 50-80 deg. C for 3-4 hours, and filtering.

Description

Composition for improving diabetes using Myongwolcho {The composition for treating diabetes}

The present invention relates to a composition for improving diabetes using Myeongwolcho, and more specifically, 60 to 90% by weight of dried crushed Myungwolcho leaves, 5 to 30% by weight of dried crushed pine needles, 1 to 5% by weight, Cordyceps sinensis 1 It is prepared by mixing ~ 5% by weight, 0.5-3% by weight of the night gate extract.

The diabetic improvement composition prepared according to the present invention contains a large amount of nutrients, such as algae gelatin, gamro acid, vitamin B, sulfur, calcium, amino acids in the leaves of Myeongwol early spring to suppress diabetes, lower blood pressure, bactericidal effect, etc. Due to steady intake, diabetes prevention and improvement, blood circulation is effective.

Diabetes, which is rapidly increasing as the awareness of health increases due to the improvement of the living standard of the modern people and the increase of human lifespan, is a chronic disease that is attracting worldwide attention. Diabetes mellitus is a metabolic syndrome characterized by a deficiency of insulin hormone or insulin resistance in the beta cells of the pancreas, as well as hyperglycemia resulting from both of these defects. Such diabetes can be divided into insulin dependent diabetes mellitus (IDDM; Type I) and insulin independent diabetes mellitus (NIDDM; Type II) caused by insulin resistance and insulin secretion impairment.

In addition, diabetes mellitus as well as glucose metabolism as well as chronic hyperglycemia causes chronic metabolic disorders. The condition is diverse and is directly caused by hyperglycemia, and includes diabetic peripheral neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cataract, keratosis, and diabetic atherosclerosis in the retina, the kidney, the nervous system, and the cardiovascular system. The number of diabetic patients is steadily increasing due to changes in lifestyle such as overeating, lack of exercise, westernized eating habits, stress, drinking and smoking. In Type I and Type II diabetes, diverse complications such as heart disease, bowel disease, ophthalmic disease, neurological disease, and stroke occur, which can lead to chronic neuropathy and cardiovascular disease due to elevated blood glucose and insulin levels over a long period of time And short-term hypoglycemia and hyperglycemia reaction cause acute complications.

Diabetes mellitus is medication, exercise and diet, and insulin medicines and various blood glucose drugs are used depending on the patient's symptoms. However, diabetes is a complex disease characterized by overgrowth of glucose in the liver, insulin resistance, and decreased glucose tolerance in muscle and adipocytes. Therefore, specific treatment alone can not prevent the occurrence of various side effects. Among them, pharmacotherapy uses insulin and chemicals, which is a constant problem for side effects and patient tolerance due to taking medications. Recently, it is possible to treat diabetes by using natural products with low side effects. There is a need for research to improve and further prevent and improve diabetic complications.

Myeongwolcho (aka diabetic vinegar, also known as life preserve vinegar in China) is a herb that grows in Paljangdo, Japan's longevity village, and its effect is to lower blood sugar and regulate high blood pressure. This Myeongwolcho was sent by the Emperor of Qin Shi to the East to save Jangsaengbulocho, and the legend is that Jangsaengbulocho is Myeongwolcho. Myeongwolcho is good for eating raw because its taste is soft and refreshing. In particular, three leaves per meal for three meals per day, steadily eating the food, the blood sugar is lowered, and after a short period of time has been reported that the effect of recovering to normal without taking blood sugar.

However, there is no invention of a composition for improving diabetes and further preventing and improving diabetic complications by using this effective Myeongwolcho.

The present invention has been invented to solve the above problems, its purpose is to contain a large amount of nutrients such as algae gelatin, gamro acid, vitamin B, sulfur, calcium, amino acids in the leaves of Myeongwolcho, diabetes suppression, blood pressure If consumed steadily due to lowering, antiseptic effect, diabetes prevention and improvement, and blood circulation is smooth.

In addition, honey, Cordyceps sinensis, night tuberculosis extracts are mixed with Myeongwolcho leaves, pine needles, which are dry and pulverized powders, which are entangled with each other, thereby reducing bitter taste and sufficiently containing an active ingredient for improving diabetes.

In addition, due to the terpene-based unique aromatic substance of the pine needles to improve the flavor of the diabetic improvement composition to facilitate the intake of consumers without objection.

In order to achieve the above object, the diabetic improvement composition according to the present invention is 60 ~ 90% by weight of dried pulverized vinegar leaves, 5 ~ 30% by weight of dried crushed pine needles, honey 1 ~ 5% by weight, Cordyceps sinensis 1 ~ 5 It is characterized in that prepared by mixing 0.5% to 3% by weight, night gate extract.

In addition, the night gate extract is characterized in that produced by filtration after heating for 3 to 4 hours at 50 ~ 80 ℃ by mixing water in the ratio of 1: 3 to 5 to the night gate.

In addition, instead of the dry pulverized pine needles, it is characterized by using a dry pulverized Angelica or dried pulverized mulberry leaves.

In addition, the dry pulverized Myeongwolcho leaves 60 to 90% by weight, dry pulverized pine needles 2 to 10% by weight, dry crushed Angelica 2 to 10% by weight, dry pulverized mulberry leaves 2 to 10% by weight, honey 1 to 5% by weight %, Cordyceps sinensis 1 to 5% by weight, night gate door extract 0.5 to 3% by weight characterized in that it was prepared by mixing.

In addition, the diabetic improvement composition is characterized in that prepared in the form of a cyclic form.

The composition for improving diabetes using Myeongwolcho according to the present invention contains a large amount of nutrients such as algae gelatin, gamro, vitamin B, sulfur, calcium, and amino acids in the leaf stem of Myeongwolcho, inhibiting diabetes, lowering blood pressure, and bactericidal effect. If you take it steadily due to prevention and improvement of diabetes, blood circulation is effective.

In addition, honey, Cordyceps sinensis, night tuberculosis extracts are mixed with the dried pulverized powder Myeongwolcho leaves, pine needles, tangled with each other, the bitter taste is reduced, and contains an active ingredient for diabetic improvement, the terpene-based unique aroma of the pine needles Due to the good aroma of the diabetic improvement composition, as well as Myeongwolcho leaves, pine needles, honey, Cordyceps sinensis, night gateway extracts are prepared by mixing the diabetic improvement composition is prepared in the form of a round form is easy to ingest.

The present invention relates to a composition for improving diabetes, 60 to 90% by weight of dried pulverized vinegar leaves, 5 to 30% by weight of dried crushed pine needles, 1 to 5% by weight of honey, 1 to 5% by weight of Cordyceps sinensis, 0.5 tongwan extract 0.5 It is prepared by mixing ~ 3% by weight.

Here, Myeongwolcho is also called life preserve, diabetic vinegar, contains a large amount of algae gelatin in the leaf stem, contains nutrients such as gamro acid, vitamin B, sulfur, calcium, amino acids, diabetes suppression, lowering blood pressure It has the effect of sterilization.

In addition, when dry grinding the Myeongwolcho, dry grinding by the method generally used in the art, but not limited to the method, but after drying in halftone paper at 1 ~ 5 days at 20 ~ 30 ℃, 150 ~ 350 mesh (mesh It is preferable to grind to).

The pine needles are 58.1% moisture, 4.5% protein, 3.9% fat, carbohydrate 19.6%, fiber 13.3%, mineral 0.6%, rich in vitamin A, B1, C, gastrointestinal diseases, hypertension, stroke, neuralgia, insomnia, anemia It is effective in asthma, blood circulation, etc. Oxypartamic acid of pine needle powder prevents aging and astringent anti-inflammatory action, and raw pine needles are rich in terpene-based aroma substances to stabilize nerves.

In addition, dry grinding of the pine needles is not limited to the method to dry grinding by a method generally used in the art, but preferably 150 to 350 mesh after drying in halftone paper for 1 to 5 days at 10-30 ℃ It is preferable to grind to (mesh).

In addition, the honey is generally used in the art and is not limited to the kind thereof. In general, honey contains honey (natural honey) and molasses (artificial honey), and contains various vitamins and enzymes, gastrointestinal diseases, diabetes mellitus, dysentery, hepatitis, gastritis, stomatitis, physical strength, digestion, constipation, and cough. It is effective for high blood pressure and fatigue recovery.

In addition, the Cordyceps sinensis is a small mushroom of Cordyceps fungus Lactobacillus excess.

Pharmacological action is effective in the central nervous system, lowering body temperature, increasing immune function, anti-cancer, increased cardiac blood flow, bronchial expansion, increased corticosteroid activity, anti-fatigue, anti-aging, anti-inflammatory, anti-microbial action.

In addition, the Cordyceps sinensis may be used by grinding dried Cordyceps sinensis into 150 to 350 mesh, or mixed with dried Cordyceps sinensis at a ratio of 1: 3 to 5 by weight, and heated at 50 to 80 ° C. for 3 to 4 hours. After filtration can be used.

In addition, the night gate extract is produced by mixing the water in the ratio of 1: 3 to 5 in the night gate, and then heated for 3 to 4 hours at 50 ~ 80 ℃.

Here, the night gate is a half-tree of dicotyledonous rosewood legumes, it is also called non-repair, Nou-geun, Hojija, wild vegetables. It grows below the foot of the mountain, and its stem stands upright and has thin and short branches with ridges and hairs. It is distributed in Korea, Japan, Taiwan, India and Australia. It also strengthens weakened energy such as lack of energy, premature ejaculation, strengthens the function of liver and kidneys, softens muscles and tendons, promotes blood circulation, treats bronchitis or asthma, soothe or congested eyes, improves weakness or weakness, Nervous breakdown treatment, lowering the blood sugar level of diabetes, loosen the blood and swelling, and diarrhea or acute gastritis are effective in relieving.

In addition, the night gate extract is mixed with water at a ratio of 1: 3 to 5 of the night gate door by heating at 60 ~ 80 ℃ for 3 to 4 hours and then manufactured by filtration to ensure that the effective components of the night gate door is not sufficiently extracted To do this.

If the water is mixed in the ratio of less than 1: 3 to the night gate, the effective components of the night gate may not be sufficiently extracted, and the water may be mixed in the ratio of more than 1: 5 relative to the weight of the night gate. In this case, it is uneconomical to use more water than necessary.

And, if the water is mixed at a ratio of 1: 3 to 5 by weight to the night gate, and heated to less than 3 hours at 50 ℃, when the filtration is effective, due to the low temperature and short heating time the effective components of the night gate is sufficiently extracted In case of filtration after heating for over 4 hours at 80 ° C, high temperature may destroy the effective components of the night gate, and it is uneconomical due to the heating time more than necessary.

Then, the diabetic improvement composition 60 ~ 90% by weight of the dried crushed Myeongwolcho leaves, 5 ~ 30% by weight of dried crushed pine needles, 1-5% by weight of honey, 1-5% by weight of Cordyceps sinensis, 0.5 ~ 3 Preparing by mixing the weight percent of the dried pulverized Myeongwolcho leaves, and the dried crushed pine needles, the honey, the Cordyceps sinensis, the night gate extract is mixed with not only enough ingredients for improving diabetes, the dry pulverized Honey, Cordyceps sinensis, Night Gwanmune extract is mixed with Myeongwolcho leaves and pine needles, which are tangled with each other and the bitter taste decreases, and the aroma of the terpene-based unique pine needles improves the fragrance of the composition for improving diabetes. Because it can be produced.

If the mixture is manufactured by mixing less than 60% by weight of the dried pulverized moonwort leaves, the mixed amount of the dried pulverized moonwort leaves may be insufficient and may not include enough components for diabetic improvement. If more than 90% by weight of the leaves mixed with more than necessary ingredients for diabetic improvement may not be mixed smoothly into honey, cordyceps, night gate extract.

And, if manufactured by mixing less than 5% by weight of the dried pulverized pine needles may not be sufficiently mixed with the active ingredients of the dried pulverized pine needles, the fragrance due to the terpene-based unique aromatic substances of the pine needles, When manufactured by mixing more than 30% by weight of the dried and pulverized pine needles are mixed more than necessary, economical and peculiar flavor of pine needles can give a strong sense of rejection to the intake.

And, if the honey is mixed at less than 1% by weight, not only can not be mixed so as to smoothly tangled the dried powdered moonshine leaf and pine needles, but also effective ingredients of honey are not sufficiently mixed, the honey When mixed in excess of 5% by weight honey is mixed with more than necessary in the dried powdered Myeongwolcho leaf and pine needles and becomes sticky and strong sweetness can give the user a feeling of rejection.

And, if the Cordyceps sinensis is less than 1% by weight, the effective components of Cordyceps may not be evenly mixed, if more than 5% by weight of the Cordyceps is not economical to mix more than necessary Cordyceps. .

And, if the amount of the night gate extract is mixed less than 0.5% by weight, the effective ingredients of the night gate may not be evenly mixed, and when the night gate extract is mixed in excess of 3% by weight more than necessary to mix the night gate It is economical.

In addition, instead of the dry pulverized pine needles may be used to dry pulverized Angelica or dried pulverized mulberry leaves.

Here, the use of the dried crushed donkey instead of the dried crushed pine needles is the medicinal herb dried dried roots of the true donkey belonging to the mountain family, hemostatic action, blood circulation, anemia prevention and treatment, constipation relief and treatment, This is because it is effective for uterine contractions and menstrual irregularities.

In addition, dry grinding the donkey is not limited to the method to dry grinding by a method generally used in the art, but after drying in halftone paper at 10 ~ 30 ℃ 1 to 5 to 150 ~ 350 mesh (mesh) It is preferable to grind.

In addition, the use of dry ground mulberry leaves instead of the dry ground pine needles is because the mulberry leaves are effective in preventing stroke, hypertension, diabetes mellitus, heart disease, lowering cholesterol, clearing blood and aging.

In addition, when the dry mulberry leaf is pulverized by a method commonly used in the art to dry pulverized, but not limited to the method, but after drying in halftone paper at 10-30 ℃ 1-5 days to 150-350 mesh (mesh) It is preferable to grind.

In addition, the dry pulverized Myeongwolcho leaves 60 to 90% by weight, dry pulverized pine needles 2 to 10% by weight, dry crushed Angelica 2 to 10% by weight, dry pulverized mulberry leaves 2 to 10% by weight, honey 1 to 5% by weight %, Cordyceps sinensis 1 to 5% by weight, can be prepared by mixing the night gate extract 0.5 to 3% by weight.

Here, 60 to 90% by weight of the dried pulverized vinegar leaf, 2 to 10% by weight of dried crushed pine needles, 2 to 10% by weight of dried crushed mulberry leaves, 2 to 10% by weight of dried pulverized mulberry leaves, 1 to 5 weight of honey %, Cordyceps sinensis 1-5% by weight, night bay door extract 0.5 to 3% by weight of the manufacture is to prepare not only the pine needles, but also mixed with the active ingredients of Angelica, mulberry leaves.

The diabetic improvement composition prepared by the above method is not particularly limited to the formulation, but is preferably prepared in a cyclic form.

When preparing the diabetic improvement composition in the form of a ring is prepared in the form of a ring of about 0.5 ~ 2cm in diameter, it is preferable to ingest three times a day, three tablets after a meal.

In addition, the diabetic improvement composition prepared by the above method has the effect of preventing and improving diabetes when steadily ingested, there is an effect that the blood circulation is smooth.

Hereinafter, the present invention will be described more specifically by way of examples. It will be apparent to those skilled in the art, however, that the following examples are illustrative of the present invention only and do not limit the scope of the present invention. That is, a simple modification or change of the present invention can be easily performed by those skilled in the art, and all such modifications and alterations can be considered to be included in the scope of the present invention.

Example 1: Diabetic improvement composition (using pine needles) prepared according to the present invention

1) Myeongwolcho leaves are dried in halftone paper for 5 days at 25 ℃ and then pulverized 200 mesh (mesh).

2) The pine needles are dried in halftone paper at 25 ° C. for 5 days and then pulverized into 200 mesh.

3) Cordyceps sinensis is pulverized dried Cordyceps sinensis into 200 mesh.

4) Mix 4kg of water with 1kg of night gate, heat at 60 ℃ for 4 hours, and filter.

5) 7kg of the dried pulverized vinegar leaf, 2kg of the dried crushed pine needles, 0.3kg of honey, 0.3kg of Cordyceps sinensis, 0.2kg of the night gate extract.

Example 2 Diabetes improvement composition prepared according to the present invention (using pine needles, Angelica, mulberry leaves)

1) Myeongwolcho leaves are dried in halftone paper for 5 days at 25 ℃ and then pulverized 200 mesh (mesh).

2) The pine needles are dried in halftone paper at 25 ° C. for 5 days and then pulverized into 200 mesh.

3) The Angelica is dried in semi-negative paper for 5 days at 25 ℃ and pulverized into 200 mesh (mesh).

4) Mulberry leaves are dried in halftone for 5 days at 25 ℃ and then pulverized 200 mesh (mesh).

5) Cordyceps sinensis is pulverized dried cordyceps into 200 mesh.

6) Mix 4kg of water with 1kg of night gate, heat at 60 ℃ for 4 hours, and filter.

7) 7kg of the dried pulverized moon leaf, 1kg of the dried crushed pine needles, 1kg of the dried crushed mulberry, 1kg of the dried pulverized mulberry leaves, 0.3kg of honey, 0.3kg of Cordyceps sinensis, 0.2kg of the night gate extract.

Experiment 1: Acute Toxicity Experiment

ICR male mice (body weight 24 ± 1g) fasted from the evening before the experiment were taken as one group, and the powders obtained by lyophilizing the extracts of Examples 1 and 2 were orally administered and observed for abnormal behavior. . The results yielded LD ₅₀ values according to the methods of Richfield J. T. and Wilcoxon F.

The results are shown in Table 1 below.

As shown in Table 1, the oral administration of the extracts of Examples 1 and 2 according to the present invention was shown to be as stable as Rosiglitazone (antidiabetic agent).

Condition LD50 (mg / kg) Route of administration Example 1 > 2000mg / kg oral- Example 2 > 2000mg / kg oral- Rosiglitazone (antidiabetic drug)
(Avandia Tab) > 1000mg / kg oral-

Experiment 2: Animal Blood Glucose Lowering Effect Experiment

In order to measure the hypoglycemic activity of the extracts prepared by Examples 1 and 2 of the present invention, the hypoglycemic effect was tested in db / db diabetic mice, which are spontaneous diabetic experimental animals. First, Examples 1 to 2 were lyophilized to be orally administered to the animals. Afterwards, 10-week-old male db / db mice with diabetes mellitus were adapted to a breeding environment for 2 weeks, and diabetic mice with a blood glucose level of about 600 mg / dL were selected as the test animals. The experimental group was divided into a control group not administering the extract of Example and a sample administration group of Examples 1 to 2, and the number of experimental animals was 5 for each group.

For the preparation and administration of the samples, the lyophilized extracts were prepared as a suspension using 0.5% CMC (Carboxymethyl-cellulose) solution, and each extract was orally administered at 500 mg / kg (body weight).

Blood glucose was measured in the tail every morning in the non-fasted state and blood glucose was measured by glucose oxidasemethod (Glucose oxidasemethod).

The results are shown in Table 2 below.

Glucose content in serum (mg / dl)

Control group

Example 1

Example 2

1 day

596.3 ± 6.2
578.2 ± 0.3
574.2 ± 2.5
3 days

587.5 ± 5.4
478.8 ± 1.1
480.3 ± 7.2
5 days

582.4 ± 5.4
420.6 ± 5.4
415.6 ± 9.5
10 days

580.2 ± 5.3
416.8 ± 5.2
413.7 ± 8.5

As shown in Table 2, it was confirmed that the group treated with the extract of Examples 1 to 2 according to the present invention has a superior hypoglycemic effect than the control group. In addition, the difference in the effect of the extract of Example 1 and Example 2 was hardly seen.

Experiment 3: Clinical hypoglycemic effect experiment

Each of the extracts of Examples 1, 2 and 15 were fed to diabetic patients three times a day, three times a day for breakfast, lunch and dinner for 30 days, and then blood glucose was measured at 5 day intervals. Blood glucose was measured using a self glucose meter after fasting for at least 8 hours. As a control group, diabetic patients who did not consume the extract were compared.

Blood glucose levels lowered to 126 mg / dL or less blood glucose were the basis for recovery to normal blood glucose. Table 3 below is a table showing the number of people who returned to normal blood sugar from 15 of diabetic patients who took each extract on the date of measuring blood glucose.

Condition Number of normal blood sugars (number of people) according to days of administration 5 days 10 days 15th 20 days 25th 30 days Example 1 1 person 1 person 2 people 7 people 9 people 12 people Example 2 2 people 2 people 3 people 7 people 10 people 12 people Control group 0 people 0 people 0 people 0 people 0 people 0 people

As shown in Table 3, the extracts of Example 1 and Example 2 were found to have the effect of restoring the blood sugar of diabetic patients to normal.

Claims (5)

In the composition for improving diabetes using Myeongwolcho,
The composition for improving diabetes using Myeongwolcho is 60 ~ 90% by weight of dried crushed Myeongwolcho leaves, 5 ~ 30% by weight of dried crushed pine needles, 1-5% by weight of honey, 1-5% by weight of Cordyceps sinensis, 0.5 ~ 0.5 Diabetes improvement composition, characterized in that prepared by mixing 3% by weight.
The method of claim 1,
The night gate extract is a diabetic improvement composition, characterized in that the water was mixed in a ratio of 1: 3 to 5 in the night gate by heating at 50 ~ 80 ℃ for 3 to 4 hours and then filtered.
The method of claim 1,
Instead of the dried crushed pine needles, the composition for improving diabetes, characterized in that the use of dried crushed mulberry leaves or dried pulverized mulberry leaves.
The method of claim 1,
The composition for improving diabetes using Myeongwolcho is 60 ~ 90% by weight of dried crushed Myeongwolcho leaves, 2 ~ 10% by weight of dried crushed pine needles, 2 ~ 10% by weight of dried crushed mulberry leaves, 2 ~ 10% by weight of dried mulberry leaves %, Honey 1 to 5% by weight, Cordyceps sinensis 1 to 5% by weight, night gate door extract 0.5 to 3% by weight of the composition for improving diabetes, characterized in that prepared by mixing.
The diabetic improvement composition prepared by the method of any one of claims 1 to 4 is characterized in that the diabetic improvement composition is prepared in the form of a cyclic form.