KR20180019113A - 제어된 약물 방출을 위한 전달 시스템 - Google Patents

제어된 약물 방출을 위한 전달 시스템 Download PDF

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KR20180019113A
KR20180019113A KR1020177036605A KR20177036605A KR20180019113A KR 20180019113 A KR20180019113 A KR 20180019113A KR 1020177036605 A KR1020177036605 A KR 1020177036605A KR 20177036605 A KR20177036605 A KR 20177036605A KR 20180019113 A KR20180019113 A KR 20180019113A
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South Korea
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group
optionally substituted
alkyl
compound
rti
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Korean (ko)
Inventor
펠릭스 크라츠
칼리드 아부아자즈
앙드레 바르네케
슈테판 데이비드 쾨스터
프리드리히 아이 놀만
시몬 발트저
올가 푹스
페르난데즈 자비에르 가르시아
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싸이트알엑스 코포레이션
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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    • C07K—PEPTIDES
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177036605A 2015-06-19 2016-06-17 제어된 약물 방출을 위한 전달 시스템 Pending KR20180019113A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562182219P 2015-06-19 2015-06-19
US62/182,219 2015-06-19
US201562261213P 2015-11-30 2015-11-30
US62/261,213 2015-11-30
US201562261563P 2015-12-01 2015-12-01
US62/261,563 2015-12-01
PCT/US2016/038223 WO2016205738A2 (en) 2015-06-19 2016-06-17 Delivery systems for controlled drug release

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KR20180019113A true KR20180019113A (ko) 2018-02-23

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US (1) US11384104B2 (enExample)
EP (2) EP3954394A1 (enExample)
JP (3) JP6948708B2 (enExample)
KR (1) KR20180019113A (enExample)
CN (2) CN107922457B (enExample)
AU (1) AU2016279051B2 (enExample)
CA (1) CA2989963A1 (enExample)
DK (1) DK3310800T3 (enExample)
ES (1) ES2909486T3 (enExample)
IL (1) IL256371B (enExample)
MA (1) MA45472A (enExample)
MX (1) MX386808B (enExample)
NZ (1) NZ738229A (enExample)
PT (1) PT3310800T (enExample)
RU (1) RU2748992C2 (enExample)
WO (1) WO2016205738A2 (enExample)
ZA (1) ZA201708234B (enExample)

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JP2019513829A (ja) * 2016-04-11 2019-05-30 ３アール ヴァロ、エス．イー．シー． 抗炎症剤、抗転移剤及び／又は抗癌剤として使用するためのアミノ安息香酸誘導体
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US10576161B2 (en) 2017-01-20 2020-03-03 Magenta Therapeutics, Inc. Compositions and methods for the depletion of CD137+ cells
EP3617221A4 (en) * 2017-04-19 2021-04-14 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. CYTOTOXIN AND CONJUGATE, USES THEREOF AND MANUFACTURING PROCESSES THEREFORE
JP7062754B2 (ja) 2017-08-15 2022-05-06 ナントセル，インコーポレイテッド ｈａＮＫセツキシマブ併用及び方法
EP3717018A1 (en) * 2017-11-30 2020-10-07 Centurion BioPharma Corporation Maytansinoid-based drug delivery systems
AU2018375787B2 (en) * 2017-11-30 2023-02-23 Ladrx Corporation Albumin-binding prodrugs of auristatin E derivatives
CN119241554A (zh) 2017-12-15 2025-01-03 四川科伦博泰生物医药股份有限公司 生物活性物偶联物及其制备方法和用途
CN110090308B (zh) * 2018-01-30 2023-03-24 四川科伦博泰生物医药股份有限公司 制备偶联物的方法
CN110227164B (zh) * 2018-03-06 2021-11-23 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用
WO2024078449A1 (en) 2022-10-09 2024-04-18 LaNova Medicines Limited Compounds, compositions and methods

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