CN107922457B - 用于控制药物释放的递送系统 - Google Patents

用于控制药物释放的递送系统 Download PDF

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CN107922457B
CN107922457B CN201680041045.0A CN201680041045A CN107922457B CN 107922457 B CN107922457 B CN 107922457B CN 201680041045 A CN201680041045 A CN 201680041045A CN 107922457 B CN107922457 B CN 107922457B
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CN107922457A (zh
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F·克拉特兹
K·阿布阿吉阿吉
A·瓦内克
S·D·寇斯特
F·I·诺尔曼
S·瓦尔泽
O·福斯
J·加西亚费尔南德斯
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Radex Co
LadRx Corp
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Sentorian Biopharmaceutical Co
CytRx Corp
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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CN201680041045.0A 2015-06-19 2016-06-17 用于控制药物释放的递送系统 Active CN107922457B (zh)

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US201562182219P 2015-06-19 2015-06-19
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US201562261213P 2015-11-30 2015-11-30
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US201562261563P 2015-12-01 2015-12-01
US62/261,563 2015-12-01
PCT/US2016/038223 WO2016205738A2 (en) 2015-06-19 2016-06-17 Delivery systems for controlled drug release

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JP2019513829A (ja) * 2016-04-11 2019-05-30 ３アール ヴァロ、エス．イー．シー． 抗炎症剤、抗転移剤及び／又は抗癌剤として使用するためのアミノ安息香酸誘導体
US10111966B2 (en) 2016-06-17 2018-10-30 Magenta Therapeutics, Inc. Methods for the depletion of CD117+ cells
US10576161B2 (en) 2017-01-20 2020-03-03 Magenta Therapeutics, Inc. Compositions and methods for the depletion of CD137+ cells
EP3617221A4 (en) * 2017-04-19 2021-04-14 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. CYTOTOXIN AND CONJUGATE, USES THEREOF AND MANUFACTURING PROCESSES THEREFORE
JP7062754B2 (ja) 2017-08-15 2022-05-06 ナントセル，インコーポレイテッド ｈａＮＫセツキシマブ併用及び方法
EP3717018A1 (en) * 2017-11-30 2020-10-07 Centurion BioPharma Corporation Maytansinoid-based drug delivery systems
AU2018375787B2 (en) * 2017-11-30 2023-02-23 Ladrx Corporation Albumin-binding prodrugs of auristatin E derivatives
CN119241554A (zh) 2017-12-15 2025-01-03 四川科伦博泰生物医药股份有限公司 生物活性物偶联物及其制备方法和用途
CN110090308B (zh) * 2018-01-30 2023-03-24 四川科伦博泰生物医药股份有限公司 制备偶联物的方法
CN110227164B (zh) * 2018-03-06 2021-11-23 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用
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