KR20180004254A - 높은 수준의 cxcl9 및 다른 바이오마커를 갖는 환자에서의 질병의 진단 및 치료를 위한 방법 및 조성물 - Google Patents
높은 수준의 cxcl9 및 다른 바이오마커를 갖는 환자에서의 질병의 진단 및 치료를 위한 방법 및 조성물 Download PDFInfo
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/521—Chemokines
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| US201562221393P | 2015-09-21 | 2015-09-21 | |
| US62/221,393 | 2015-09-21 | ||
| US201562246949P | 2015-10-27 | 2015-10-27 | |
| US62/246,949 | 2015-10-27 | ||
| PCT/EP2016/060360 WO2016177913A1 (en) | 2015-05-07 | 2016-05-09 | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
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| US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| EA037532B1 (ru) | 2015-05-07 | 2021-04-08 | Новиммун Са | Способы и композиции для диагностики и лечения заболеваний у пациентов, имеющих повышенные уровни cxcl9 и других биомаркеров |
| US11840564B2 (en) | 2015-06-09 | 2023-12-12 | Children's Hospital Medical Center | Dosing algorithm for complement inhibitor |
| BR112019008156A2 (pt) * | 2016-10-24 | 2019-07-02 | Novimmune Sa | métodos, composições e regimes de dosagem no tratamento ou prevenção de indicações relacionadas com interferon-gama |
| CN109164266B (zh) * | 2017-11-27 | 2021-09-24 | 首都医科大学附属北京友谊医院 | 细胞因子在区分淋巴瘤相关噬血细胞综合征和淋巴瘤中的应用 |
| US20210052593A1 (en) * | 2018-03-09 | 2021-02-25 | Children's Hospital Medical Center | Compositions and Methods for the Treatment of Macrophage Activation Syndrome |
| WO2021185832A1 (en) | 2020-03-16 | 2021-09-23 | Swedish Orphan Biovitrum Ag | New therapeutic treatment |
| JP7396213B2 (ja) * | 2020-06-22 | 2023-12-12 | Tdk株式会社 | データ解析システム、データ解析方法及びデータ解析プログラム |
| CN115812671A (zh) * | 2022-11-17 | 2023-03-21 | 青岛大学 | 帕金森病动物模型的建立方法及其应用 |
Family Cites Families (28)
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| US5096705A (en) | 1981-10-19 | 1992-03-17 | Genentech, Inc. | Human immune interferon |
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4599306A (en) | 1983-04-15 | 1986-07-08 | Amgen | Monoclonal antibodies which specifically bind to human immune interferon |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| WO1994014467A1 (en) | 1992-12-29 | 1994-07-07 | Genentech, Inc. | Treatment of inflammatory bowel disease with ifn-gamma inhibitors |
| US5888511A (en) | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| EP1135415B1 (en) | 1998-12-01 | 2010-08-11 | Facet Biotech Corporation | Humanized antibodies to gamma-interferon |
| US6534059B2 (en) | 2001-06-05 | 2003-03-18 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
| US6861056B2 (en) | 2001-06-05 | 2005-03-01 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| KR100913714B1 (ko) | 2001-11-08 | 2009-08-24 | 패시트 바이오테크 코포레이션 | Ｉｇｇ 항체의 안정한 액상 약학 제형물 |
| WO2003097082A2 (en) | 2002-05-17 | 2003-11-27 | Protein Design Labs | Treatment of crohn's disease or psoriasis using anti-inteferon gamma antibodies |
| WO2004034988A2 (en) | 2002-10-16 | 2004-04-29 | Amgen Inc. | Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| ATE541859T1 (de) | 2005-01-27 | 2012-02-15 | Novimmune Sa | Humane anti-interferon-gamma-antikörper und verfahren zu ihrer verwendung |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| WO2010042705A1 (en) | 2008-10-09 | 2010-04-15 | Medimmune, Llc | Antibody formulation |
| AU2010338305A1 (en) * | 2009-12-29 | 2012-05-24 | F. Hoffmann-La Roche Ag | Antibody formulation |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
| PL2691112T3 (pl) * | 2011-03-31 | 2018-09-28 | Merck Sharp & Dohme Corp. | Stabilne preparaty przeciwciał przeciw ludzkiemu receptorowi programowanej śmierci pd-1 i terapie powiązane |
| CN104159919A (zh) * | 2011-11-23 | 2014-11-19 | 安姆根有限公司 | 使用抗干扰素γ抗体的治疗方法 |
| WO2016103093A1 (en) * | 2014-12-23 | 2016-06-30 | Pfizer Inc. | Stable aqueous antibody formulation for anti tnf alpha antibodies |
| EA037532B1 (ru) | 2015-05-07 | 2021-04-08 | Новиммун Са | Способы и композиции для диагностики и лечения заболеваний у пациентов, имеющих повышенные уровни cxcl9 и других биомаркеров |
| US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
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| JP2018515493A (ja) | 2018-06-14 |
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| BR112017023867A2 (pt) | 2018-07-24 |
| MX2022001008A (es) | 2022-02-22 |
| WO2016177913A1 (en) | 2016-11-10 |
| AU2016257023B2 (en) | 2022-06-30 |
| CA2985001A1 (en) | 2016-11-10 |
| IL302519A (en) | 2023-07-01 |
| JP2021100943A (ja) | 2021-07-08 |
| IL282923A (en) | 2021-06-30 |
| EA037532B1 (ru) | 2021-04-08 |
| EP3292147A1 (en) | 2018-03-14 |
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