KR20170123329A - 단백질병증을 치료하기 위한 방법 - Google Patents
단백질병증을 치료하기 위한 방법 Download PDFInfo
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- KR20170123329A KR20170123329A KR1020177027604A KR20177027604A KR20170123329A KR 20170123329 A KR20170123329 A KR 20170123329A KR 1020177027604 A KR1020177027604 A KR 1020177027604A KR 20177027604 A KR20177027604 A KR 20177027604A KR 20170123329 A KR20170123329 A KR 20170123329A
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07—ORGANIC CHEMISTRY
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- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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| US62/131,071 | 2015-03-10 | ||
| PCT/US2016/021512 WO2016145046A1 (en) | 2015-03-10 | 2016-03-09 | Methods for treating proteinopathies |
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| KR20170123329A true KR20170123329A (ko) | 2017-11-07 |
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| BR112019027029A2 (pt) * | 2017-06-19 | 2020-07-14 | Kainos Medicine, Inc. | moduladores de alfa-sinucleina |
| TWI644673B (zh) * | 2017-07-27 | 2018-12-21 | 百朗克股份有限公司 | 頭孢曲松的用途 |
| WO2020163244A1 (en) * | 2019-02-04 | 2020-08-13 | Genzyme Corporation | Methods for treating symptoms and disorders associated with lysosomal storage diseases |
| US12527776B2 (en) | 2019-02-04 | 2026-01-20 | Genzyme Corporation | Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS) |
| BR112022009409A2 (pt) * | 2019-11-15 | 2022-08-09 | Yuhan Corp | Novos derivados que têm grupamento 2,3-dihidro-1h-indeno ou 2,3-dihidrobenzofurano ou sal farmaceuticamente aceitável dos mesmos e composições farmacêuticas que os compreendem |
| EP4100009A1 (en) | 2020-02-03 | 2022-12-14 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| KR20230005813A (ko) | 2020-02-28 | 2023-01-10 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| BR112022017530A2 (pt) | 2020-03-17 | 2022-10-18 | Sumitomo Pharma Co Ltd | Derivado de oxadiazol |
| BR112022019041A2 (pt) * | 2020-03-23 | 2022-12-27 | Praxis Prec Medicines Inc | Inibidores de kcnt1 e métodos de uso |
| KR20230043024A (ko) * | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
| MX2023001285A (es) | 2020-07-30 | 2023-02-22 | Genzyme Corp | Metodos para reducir la concentracion de glicoesfingolipidos en el tejido cerebral y metodos de tratamiento de enfermedades neurodegenerativas que implican los mismos. |
| US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| KR20250106321A (ko) | 2022-12-01 | 2025-07-09 | 젠자임 코포레이션 | 강력하거나 중간 수준인 cyp3a4 억제제와 조합한 벤글루스타트 |
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| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| CN103917094B (zh) * | 2011-03-18 | 2016-11-09 | 建新公司 | 葡萄糖基神经酰胺合酶抑制剂 |
| US9845327B2 (en) * | 2011-06-22 | 2017-12-19 | The General Hospital Corporation | Treatment of proteinopathies |
| MA37975B2 (fr) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
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| PL3267983T3 (pl) | 2024-05-13 |
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| TW201642855A (zh) | 2016-12-16 |
| JP2021119185A (ja) | 2021-08-12 |
| IL254393A0 (en) | 2017-11-30 |
| US20180036295A1 (en) | 2018-02-08 |
| HUE065628T2 (hu) | 2024-06-28 |
| CA2978883A1 (en) | 2016-09-15 |
| JP2018507886A (ja) | 2018-03-22 |
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| EP4349408A3 (en) | 2024-06-19 |
| EP3267983B1 (en) | 2023-12-20 |
| PT3267983T (pt) | 2024-03-12 |
| AU2016229826A1 (en) | 2017-10-26 |
| MX2017011598A (es) | 2017-12-20 |
| US20200197374A1 (en) | 2020-06-25 |
| JP7374149B2 (ja) | 2023-11-06 |
| HK1244217A1 (zh) | 2018-08-03 |
| EP3267983A1 (en) | 2018-01-17 |
| CN107872976A (zh) | 2018-04-03 |
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