KR20170115042A - Akt 키나아제의 저해제 - Google Patents
Akt 키나아제의 저해제 Download PDFInfo
- Publication number
- KR20170115042A KR20170115042A KR1020177019939A KR20177019939A KR20170115042A KR 20170115042 A KR20170115042 A KR 20170115042A KR 1020177019939 A KR1020177019939 A KR 1020177019939A KR 20177019939 A KR20177019939 A KR 20177019939A KR 20170115042 A KR20170115042 A KR 20170115042A
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- South Korea
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- optionally substituted
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- cyclohexyl
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- 0 *C(C(CC1)CCC1N(*)*)C(NC(C=C1*)=I*=C1c1ccc(C(*)(*)N)cc1)=O Chemical compound *C(C(CC1)CCC1N(*)*)C(NC(C=C1*)=I*=C1c1ccc(C(*)(*)N)cc1)=O 0.000 description 3
- YPTIKGDPFWTLCB-UHFFFAOYSA-N CC(C(CC1)CCC1N(C)C(OC)=O)C(Nc1cnc(-c2ccc(C3(CCC3)N)cc2)c(-c2ccccc2)c1)=O Chemical compound CC(C(CC1)CCC1N(C)C(OC)=O)C(Nc1cnc(-c2ccc(C3(CCC3)N)cc2)c(-c2ccccc2)c1)=O YPTIKGDPFWTLCB-UHFFFAOYSA-N 0.000 description 1
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- KWRRMHDUQXVIFX-PGCGBBBBSA-N CC(C)(C)OC(N[C@](C1)(C[C@H]1O)c(cc1)ccc1-c(c(-c1ccccc1)c1)ncc1N)=O Chemical compound CC(C)(C)OC(N[C@](C1)(C[C@H]1O)c(cc1)ccc1-c(c(-c1ccccc1)c1)ncc1N)=O KWRRMHDUQXVIFX-PGCGBBBBSA-N 0.000 description 1
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- ZLRXMUDECKAXLJ-FDCWXKLVSA-N CCC(N(C)[C@H]1CC[C@H](CC(Nc2ncc(-c3ccc([C@](C4)(C[C@@]4(C)O)N)cc3)c(-c(cccc3)c3F)c2)=O)CC1)=O Chemical compound CCC(N(C)[C@H]1CC[C@H](CC(Nc2ncc(-c3ccc([C@](C4)(C[C@@]4(C)O)N)cc3)c(-c(cccc3)c3F)c2)=O)CC1)=O ZLRXMUDECKAXLJ-FDCWXKLVSA-N 0.000 description 1
- JDGNVSYKSXTYIC-XNLZVULHSA-N CCC(N(CC)C1CCC(CC(Nc2ncc(-c3ccc([C@](C4)(C[C@@]4(C)O)N)cc3)c(-c3ccccc3)c2)=O)CC1)=O Chemical compound CCC(N(CC)C1CCC(CC(Nc2ncc(-c3ccc([C@](C4)(C[C@@]4(C)O)N)cc3)c(-c3ccccc3)c2)=O)CC1)=O JDGNVSYKSXTYIC-XNLZVULHSA-N 0.000 description 1
- IJUGXGRPSRYQKJ-UNYPOBEMSA-N C[C@H](c(cc1)ccc1-c(c(-c1ccccc1)c1)ncc1NC(CC(CC1)CCC1N(C)C(C)=O)=O)N Chemical compound C[C@H](c(cc1)ccc1-c(c(-c1ccccc1)c1)ncc1NC(CC(CC1)CCC1N(C)C(C)=O)=O)N IJUGXGRPSRYQKJ-UNYPOBEMSA-N 0.000 description 1
- NWIZPGJLBRXQBL-IJSJNOHVSA-N C[C@](C1)(C[C@@]1(c(c(F)c1)ccc1-c(c(-c1ccccc1)c1)nnc1NC(C[C@H](CC1)CC[C@@H]1N(C)C(C)=O)=O)N)O Chemical compound C[C@](C1)(C[C@@]1(c(c(F)c1)ccc1-c(c(-c1ccccc1)c1)nnc1NC(C[C@H](CC1)CC[C@@H]1N(C)C(C)=O)=O)N)O NWIZPGJLBRXQBL-IJSJNOHVSA-N 0.000 description 1
- MVMNEBZGHMUIHG-YKBCLDEGSA-N C[C@](C1)(C[C@@]1(c(cc1)ccc1-c(c(-c1ccccc1)c1)cnc1NC(CC(CC1)CCC1N(C)CCOC)=O)N)O Chemical compound C[C@](C1)(C[C@@]1(c(cc1)ccc1-c(c(-c1ccccc1)c1)cnc1NC(CC(CC1)CCC1N(C)CCOC)=O)N)O MVMNEBZGHMUIHG-YKBCLDEGSA-N 0.000 description 1
- HVQOJXPELWEIGN-OKDASEJXSA-N Cc1c[s]cc1-c1cc(NC(C[C@H](CC2)CC[C@@H]2N(C)S(C)(=O)=O)=O)cnc1-c1ccc(C2(CCC2)N)cc1 Chemical compound Cc1c[s]cc1-c1cc(NC(C[C@H](CC2)CC[C@@H]2N(C)S(C)(=O)=O)=O)cnc1-c1ccc(C2(CCC2)N)cc1 HVQOJXPELWEIGN-OKDASEJXSA-N 0.000 description 1
- ZZOMDFZZPXKCOT-UHFFFAOYSA-N NC(C1)(CC1(F)F)c(cc1)ccc1-c(c(-c1ccccc1)c1)nnc1NC(CC(CC1)CCC1N(CCO1)C1=O)=O Chemical compound NC(C1)(CC1(F)F)c(cc1)ccc1-c(c(-c1ccccc1)c1)nnc1NC(CC(CC1)CCC1N(CCO1)C1=O)=O ZZOMDFZZPXKCOT-UHFFFAOYSA-N 0.000 description 1
- DUYMKPUFGYEZPW-GMSIQHHHSA-N N[C@](C1)(C[C@@H]1F)c(cc1)ccc1-c(c(-c1ccccc1)c1)ncc1NC(C[C@H](CC1)CC[C@@H]1N(CCO1)C1=O)=O Chemical compound N[C@](C1)(C[C@@H]1F)c(cc1)ccc1-c(c(-c1ccccc1)c1)ncc1NC(C[C@H](CC1)CC[C@@H]1N(CCO1)C1=O)=O DUYMKPUFGYEZPW-GMSIQHHHSA-N 0.000 description 1
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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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| GB201423087 | 2014-12-23 | ||
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| GBGB1508787.7A GB201508787D0 (en) | 2014-12-23 | 2015-05-22 | Pharmaceutically active compounds |
| GB1508787.7 | 2015-05-22 | ||
| GBGB1519919.3A GB201519919D0 (en) | 2015-11-11 | 2015-11-11 | Pharmaceutically active compounds |
| GB1519919.3 | 2015-11-11 | ||
| PCT/EP2015/081168 WO2016102672A2 (en) | 2014-12-23 | 2015-12-23 | Pharmaceutically active compounds |
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| KR20170115042A true KR20170115042A (ko) | 2017-10-16 |
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| CA2971763A1 (en) * | 2014-12-23 | 2016-06-30 | Bergenbio Asa | Inhibitors of akt kinase |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| WO2018130184A1 (zh) | 2017-01-13 | 2018-07-19 | 江苏恒瑞医药股份有限公司 | 1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用 |
| WO2019158070A1 (zh) * | 2018-02-15 | 2019-08-22 | 杭州阿诺生物医药科技有限公司 | A2a和/或a2b受体拮抗剂 |
| JP2021523379A (ja) | 2018-05-14 | 2021-09-02 | ベルゲンビオ アーエスアー | 血清バイオマーカー |
| CN111171065A (zh) * | 2020-02-26 | 2020-05-19 | 上海博黑生物科技有限公司 | 一种(4-(1-((叔丁氧基羰基)氨基)环丙基)苯基)硼酸酯的合成方法 |
| KR102698413B1 (ko) | 2020-05-05 | 2024-08-26 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| CN115916196A (zh) * | 2020-05-05 | 2023-04-04 | 纽威伦特公司 | 杂芳族大环醚化学治疗剂 |
| KR102853833B1 (ko) * | 2020-12-21 | 2025-09-02 | 동우 화인켐 주식회사 | 양자점, 양자점 분산체, 광변환 경화성 조성물, 컬러필터, 광변환 적층기재 및 화상표시장치 |
| WO2025066935A1 (en) * | 2023-09-28 | 2025-04-03 | Hepaitech (Beijing) Biopharma Technology Co., Ltd. | Compounds, compositions and methods thereof |
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| US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US20070185152A1 (en) | 2004-03-02 | 2007-08-09 | Smithkline Beecham Corporation | Inhibitors of akt activity |
| AU2005233584B2 (en) * | 2004-04-09 | 2010-12-09 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
| AU2013355110B2 (en) | 2012-12-07 | 2017-11-09 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CA2971763A1 (en) * | 2014-12-23 | 2016-06-30 | Bergenbio Asa | Inhibitors of akt kinase |
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| WO2016102672A3 (en) | 2016-08-18 |
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| AU2015370911A1 (en) | 2017-08-10 |
| AU2015370911B2 (en) | 2020-07-09 |
| EP3240784A2 (en) | 2017-11-08 |
| CA2971763A1 (en) | 2016-06-30 |
| JP2018500351A (ja) | 2018-01-11 |
| WO2016102672A2 (en) | 2016-06-30 |
| US10336702B2 (en) | 2019-07-02 |
| US20180029985A1 (en) | 2018-02-01 |
| CN107207472B (zh) | 2020-08-14 |
| US20200010421A1 (en) | 2020-01-09 |
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